CN104383318A - Chinese traditional medicine composition for treating tuberculosis and preparation method of Chinese traditional medicine composition - Google Patents
Chinese traditional medicine composition for treating tuberculosis and preparation method of Chinese traditional medicine composition Download PDFInfo
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Abstract
The invention relates to a Chinese traditional medicine composition for treating tuberculosis and a preparation method of the Chinese traditional medicine composition. The Chinese traditional medicine composition is prepared from the following raw materials: berchemia lineate, ardisia japonica, heartleaf houttuynia herbs, beautiful millettia roots, arrowleaf abelmoschus roots, perny false fairybells rhizomes, eclipta alba, cochinchinese asparagus roots, dwarf lilyturf tubers, erythrinae barks, hairyvein agrimonia herbs, tamariskoid spikemoss herbs, lalang grass rhizomes and honeysuckle stem parasite. The Chinese traditional medicine composition has functions of nourishing yin and moistening lung, nourishing yin and clearing heat, and has a good curative effect on tuberculosis.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to one and treat phthisical Chinese medicine composition and preparation method thereof.
Background technology
To be tubercule bacillus invade pulmonary by respiratory tract infection to pulmonary tuberculosis causes inflammation reaction.Tubercule bacillus usually resides in respiratory bronchioles or alveolar and is transmitted to another person by the suction microdroplet that carries disease germs by a people; It yet can not carry out the milk of pasteur's method sterilization by drinking contaminated and enter human body by gastrointestinal tract, also enters by skin injury once in a while.The change of its basic pathology has three aspects of oozing out, breed and go bad.When body immunity strengthen and under antibacterial drug therapy focus can heal gradually.Belong to " pulmonary tuberculosis " category of the traditional Chinese medical science.
Chinese medicine thinks that the primary disease cause of disease is nothing more than endexoteric two aspects, and exopathogenic factor infects, and endogenous cause of ill is QI and blood deficiency, cloudy essence consume.Because healthy energy is first hindered, body void is not multiple, then consumptive disease worm is taken advantage of a weak point in opponent's defence and invades, and consumptive disease worm-eaten lung, lack of lung-YIN, injury of blood vessel of the lung by heat is then shown in the diseases such as dry cough, spitting of blood, parched throat.The deficiency of the lung can not transporation of body fluid, and kidney loses the source grown, then sick and in kidney, deficiency of kidney yin, asthenic fire disturbance, then see osteopyrexia and fever, man's nocturnal emission, woman's amenorrhea, very then kidney-YIN being deficient, hyperactivity of hesrt-fire and liver-fire, on walk what lung, more to the bright lung yin that disappears, then see that night sweat is insomnia, irritated susceptible to get angry, the diseases such as pain in chest and hypochondrium.The deficiency of the lung consumes the autotrophy of taking mother-qi by force again, then sick and in spleen, deficiency of the spleen causing weakness of QI, and sees and breathe hard, the diseases such as weak, anorexia, loose stool.In a word, primary disease begins mostly to be consumption of YIN-fluid, and disease is lung, and continue then hyperactivity of fire caused by deficiency of YIN, and lung kidney is with sick or deficiency of both QI and YIN, and lung spleen is with sick.
The Syndrome Types of TCM of pulmonary tuberculosis and method for the treatment of:
1, lung yin virtual loss: hectic fever flushed cheeks, the few expectorant of dry cough or sputum mixed with blood, chest pain, dryness of the throat, red tongue, yellow and thin fur, Tianjin is few, thready and rapid pulse.
Method for the treatment of: nourishing YIN and moistening the lung, relieving cough and resolving phlegm.
2, hyperactivity of fire caused by deficiency of YIN: night sweat is had a sleepless night, dysphoria with feverish sensation in the chest palms and soles, osteopyrexia and fever, being irritable and getting angry easily, the few expectorant of cough or the yellow thickness of expectorant, repeatedly spit blood, amount polychrome is fresh, and tugging pain over the chest and hypochondrium, man's nocturnal emission, deep red tongue, pulse condition is counted accurately.
Method for the treatment of: YIN nourishing supports lung, resolving heat and reducing pathogenic fire.
3, deficiency of both QI and YIN: cough is breathed hard, and expectoration is rare clearly, occasionally has spitting of blood, spiritlessness and weakness, spontaneous sweating, or lack of appetite abdominal distention, loose stool.Red tongue is tender, thin fur, weak pulse and counting.
Method for the treatment of: replenishing QI to invigorate the spleen, nourishing the lung to arrest cough.
4, deficiency of both YIN and YANG: cough with dyspnea is panted, expectorant show bubble or folder blood, cold physique spontaneous perspiration, hoarseness, emaciated physique.Or with the disease such as edema, diarrhoea.Pale tongue and few Tianjin, tongue light is shelled, and rapid pulse or void are unable greatly.
Method for the treatment of: warming and recuperating the spleen and kidney, enrich and benefit essence and blood.
Summary of the invention
The object of this invention is to provide one and treat phthisical Chinese medicine composition;
Another object of the present invention is to provide one and treats phthisical Chinese medicine composition preparation method.
The object of the invention is by following technical scheme realize:
The phthisical Chinese medicine composition for the treatment of of the present invention, it is prepared from by the raw material comprising following weight portion:
Radix berchemiae lineatae 30-50 part, Herba Ardisiae Japonicae 25-50 part, Herba Houttuyniae 15-25 part, Millettia Speciosa 25-50 part, Radix Abelmoschi Sagittifolii 20-30 part, Rhizoma disporopsis pernyi 15-25 part, Herba Ecliptae 20-40 part, Radix Asparagi 5-15 part, Radix Ophiopogonis 5-15 part, Cortex erythrinae 15-25 part, Herba Agrimoniae 5-15 part, Herba Selaginellae 3-12 part, Rhizoma Imperatae 10-30 part, the parasitic 15-30 part of Caulis Lonicerae.
Preferably, be prepared from by the raw material comprising following weight portion:
Radix berchemiae lineatae 35-45 part, Herba Ardisiae Japonicae 30-40 part, Herba Houttuyniae 18-23 part, Millettia Speciosa 30-40 part, Radix Abelmoschi Sagittifolii 23-28 part, Rhizoma disporopsis pernyi 18-23 part, Herba Ecliptae 25-35 part, Radix Asparagi 8-12 part, Radix Ophiopogonis 8-12 part, Cortex erythrinae 18-23 part, Herba Agrimoniae 8-12 part, Herba Selaginellae 5-10 part, Rhizoma Imperatae 15-25 part, the parasitic 20-25 part of Caulis Lonicerae.
More excellent, be prepared from by the raw material comprising following weight portion:
Radix berchemiae lineatae 40 parts, Herba Ardisiae Japonicae 35 parts, Herba Houttuyniae 20 parts, Millettia Speciosa 35 parts, Radix Abelmoschi Sagittifolii 25 parts, Rhizoma disporopsis pernyi 20 parts, Herba Ecliptae 30 parts, Radix Asparagi 10 parts, Radix Ophiopogonis 10 parts, Cortex erythrinae 20 parts, Herba Agrimoniae 10 parts, Herba Selaginellae 8 parts, Rhizoma Imperatae 20 parts, parasitic 23 parts of Caulis Lonicerae.
Below the crude drug source of Chinese medicine composition of the present invention:
Radix berchemiae lineatae, Rhamnaceae hook fold plant spire Radix Berchemiae Giraldianae Berchemia lineata (L.) DC., is used as medicine with root.Micro-hardship, puckery, flat.Removing stasis to stop bleeding, antitussive pain relieving.For hemoptysis of pulmonary tuberculosis, taste-blindness rate is hemorrhage, schizophrenia, traumatic injury, rheumatic ostalgia, furuncle furuncle and phyma, deradenoncus, painful and swollen testis.
Herba Ardisiae Japonicae, Myrsinacea Ardisa plant Herba Ardisiae Japonicae Ardisia japonica (Hornsted) Blume, is used as medicine with Herb.Relieving cough and resolving phlegm, removing toxic substances of dispeling the wind, promoting blood circulation and stopping pain.For bronchitis, lobar pneumonia, infantile pneumonia, pulmonary tuberculosis, hepatitis, dysentery, acute nephritis, urinary tract infection, stimulates the menstrual flow, traumatic injury, bones and muscles pain due to rheumatism; Skin itching is controlled in external, dermatitis rhus.
Herba Houttuyniae is the dry aerial parts of saururaceae plant houttuynia cordata Houttuynia cordata Thunb..Pungent, be slightly cold.Return lung meridian.Heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, inducing diuresis for treating stranguria syndrome.For lung abscess vomiting pus, expectorant dyspnea of heat type is coughed, hematodiarrhoea, pyretic stranguria, carbuncle sore tumefacting virus.
Millettia Speciosa, is pulse family Millettia plant beautiful millettia Millettia specisoa Champ., is used as medicine with root.Sweet, flat.Tonify deficiency lung moistening, strong muscle is active.For lumbar muscle strain, rheumatic arthritis, pulmonary tuberculosis, pulmonary tuberculosis, chronic hepatitis, seminal emission, leucorrhea.
Radix Abelmoschi Sagittifolii, Malvaceae arrowleaf abelmoschus Abelmoschus esquirolii (Levl) S. Y. Hu [A. moschatus (L.) Medic. var. tuberosus; A. saglttifolius auct. non (Kurz) Merr.], be used as medicine with root, leaf.Micro-sweet, flat.Nourishing YIN and clearing away heat, evacuation of pus is drawn out pus by applying a plaster to the affected part.Cure mainly pulmonary tuberculosis, xeropulmonary cough, puerperal constipation, neurasthenia.Carbuncle pyogenic infections from tumour or sore is controlled in external.
Rhizoma disporopsis pernyi, Liliaceae false Disporum Salisb plant bamboo root false cantonese fairy bells Disporopsis perryi (Hua) Diels, is used as medicine with root stock.Sweet, flat.Nourishing YIN and moistening the lung, promoting the production of body fluid to quench thirst.Hyperhidrosis is coughed, xerostomia, puerperal asthenia for void.
Herba Ecliptae is the dry aerial parts of feverfew Eclipta prostrata Eclipta prostrata L..Sweet, sour, cold.Return kidney, Liver Channel.Nourishing the liver and kidney, cooling blood for hemostasis.For odontoseisis, early whitening of beard and hair, vertigo and tinnitus, soreness of the waist and knees, YinXuXueRe, haematemesis, epistaxis, hematuria, dysentery, metrostaxis, traumatic hemorrhage.
Radix Asparagi is the dried root of liliaceous plant Radix Asparagi Asparagus cochinchinensis (Lour.) Merr..Sweet, bitter, cold.Return lung, kidney channel.Nourishing YIN to relieve dryness, lung heat clearing is promoted the production of body fluid.For dryness of the lung dry cough, pertussis expectorant sticks, dry throat and mouth, dryness of the intestine constipation.
Radix Ophiopogonis is the dried root of liliaceous plant Radix Ophiopogonis (dwarf lilyturf) Ophiopogon japonicus (Thunb.) Ker-Gawl..Sweet, micro-hardship, is slightly cold.GUIXIN, lung, stomach warp.YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.For dryness of the lung dry cough.Chronic consumptive disease is coughed, and Tianjin wound is thirsty, vexed insomnia, and interior-heat is quenched one's thirst, dryness of the intestine constipation; Pharyngeal diphtheria.
Cortex erythrinae, the bark of pulse family Erythrinae Arborescentis Erythrina indica Lam. or root bark.Hardship, flat.Return liver, kidney channel.Wind-damp dispelling, channels sootheing and network vessel quickening.For rheumatic numbness, waist hamstring bone pain, traumatic injury; Various stubborn dermatitis is controlled in external.
Herba Agrimoniae is the dry aerial parts of rosaceous plant Radix Agrimoniae Agrimonia pilosa Ledeb..Bitter, puckery, flat.GUIXIN, Liver Channel.Astringing to arrest bleeding, preventing the attack (or recurrence) of malaria, dysentery relieving, removing toxic substances.For hemoptysis, spit blood, metrostaxis, malaria, dysentery, de-power impairment caused by overstrain, carbuncle sore tumefacting virus, pudendal pruritus leukorrhagia.
Herba Selaginellae is the dry herb of Spikemoss plant Herba Selaginellae Selaginella tamariscina (Beauv.) Spring or Selaginella pulvinata Selaginella pulvinata (HooK.et Grev.) Maxim..Pungent, flat.Return liver, heart channel.Promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea.WEIJIA mass in the abdomen, injury from falling down.Herba Selaginellae charcoal removing stasis to stop bleeding.For spitting blood, metrorrhagia, has blood in stool, proctoptosis.
Rhizoma Imperatae is the dry rhizome of grass Herba Imperatae Imperata cylindrica Beauv. var. major (Nees) C. E. Hubb..Sweet, cold.Return lung, stomach, urinary bladder channel.Cooling blood for hemostasis, clearing away heat and promoting diuresis.Spit blood for heat in blood, epistaxis, hematuria, calentura excessive thirst, jaundice, edema, the puckery pain of pyretic stranguria; Acute nephritis edema.
Caulis Lonicerae is parasitic, is the band stem branch and leaf of Loranthaceae Loranthus plant Herba Taxilli Loranthus parasiticus (L.) Merr., is used as medicine with Herb.Sweet in the mouth, hardship, cool in nature.Enter lung, stomach, large intestine channel.Wind and heat dispersing, subduing swelling and detoxicating.Control anemopyretic cold, influenza, parotitis, mastitis, tonsillitis, pulmonary infection, appendicitis, acute/chronic pharyngitis, the petty inflammation of cervix uteri, rheumatic arthritis.
Another aspect of the present invention there is provided the preparation method of the active component of Chinese medicine composition of the present invention, and the method adopts the ethanol extraction of water extraction or 40-80% concentration expressed in percentage by volume to be prepared from.Concrete preparation method is as follows:
Scheme one: get whole 14 taste medical materials, extracting in water 2-3 time after mixing, each amount of water is equivalent to the 6-12 of medical material gross weight doubly, each extraction time is 1-3 hour, merge extractive liquid, filters, when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.15-1.20, obtains active component.
Scheme two: get whole 14 taste medical materials, 40-80% alcohol reflux 2-3 time is used after mixing, each ethanol consumption is 4-10 times of medical material total amount, extraction time is 1-4 hour, merge extractive liquid, filter, when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.15-1.20, obtains active component.
Scheme three: get whole 14 taste medical materials, extracting in water 2-3 time after mixing, each amount of water is equivalent to the 6-12 of medical material gross weight doubly, each extraction time is 1-3 hour, merge extractive liquid, filters, and when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.15-1.20, add ethanol, make alcohol content be 40-70%, leave standstill 12-24 hour, filter, when filtrate is concentrated into 70-80 DEG C, relative density is the extractum of 1.10-1.25, obtains active component.
The phthisical Chinese medicine for the treatment of of the present invention, with pharmaceutically acceptable carrier combination, can also make various oral formulations, as tablet, capsule, oral liquid, syrup, mixture etc.
Pharmaceutically acceptable carrier of the present invention includes but not limited to following:
Oral formulations:
Diluent: starch, Icing Sugar, lactose, dextrin, microcrystalline Cellulose, inorganic salt, sugar alcohols etc.
Wetting agent and binding agent: purified water, ethanol, gelatin, Polyethylene Glycol, cellulose derivative etc.
Disintegrating agent: starch, carboxymethyl starch sodium, cellulose derivative, polyvinylpolypyrrolidone etc.
Lubricant: magnesium stearate, micropowder silica gel, Pulvis Talci, Polyethylene Glycol etc.
Cosolvent: water, ethanol, glycerol, propylene glycol, liquid Paraffin, plant wet goods.
Correctives: sucrose, monosaccharide, aromatic etc.
Antiseptic: benzoic acid, sorbic acid, methyl ester, ethyl ester, propyl ester etc.
Method 1: tablet
Get one of scheme one to scheme three gained active component, add tablet and commonly use adjuvant, production method is prepared into Tablets routinely.
Above-mentioned tablet is commonly used adjuvant and is comprised one of diluent, wetting agent, binding agent, disintegrating agent, lubricant or whole.
Method 2: capsule
Get one of scheme one to scheme three gained active component, add capsule and commonly use adjuvant, production method is prepared into capsule of the present invention routinely.
Above-mentioned capsule is commonly used adjuvant and is comprised one of diluent, wetting agent, binding agent, disintegrating agent, lubricant or whole.
Method 3: syrup
Get one of scheme one to scheme three gained active component, add syrup and commonly use adjuvant, production method is prepared into syrup of the present invention routinely.
Above-mentioned syrup is commonly used adjuvant and is comprised one of correctives, antiseptic, cosolvent or whole.
Method 4: mixture
Get one of scheme one to scheme three gained active component, add mixture and commonly use adjuvant, production method is prepared into mixture of the present invention routinely.
Above-mentioned mixture is commonly used adjuvant and is comprised one of correctives, antiseptic or whole.
Method 5: oral liquid
Get one of scheme one to scheme three gained active component, dissolve after-purification, concentrate, add oral liquid and commonly use adjuvant, production method is prepared into oral liquid of the present invention routinely.
Above-mentioned oral liquid is commonly used adjuvant and is comprised one of correctives, antiseptic, cosolvent or whole.
Multiple formulations with reference to modern pharmacological research achievement, through test for many years, is screened, be have found and can effectively treat phthisical Chinese medicine formula by the applicant on the basis of research tradition tcm syndrome differentiation and treatment.
Chinese medicine composition effective ingredient disclosed in this invention is prepared from by Radix berchemiae lineatae, Herba Ardisiae Japonicae, Herba Houttuyniae, Millettia Speciosa, Radix Abelmoschi Sagittifolii, Rhizoma disporopsis pernyi, Herba Ecliptae, Radix Asparagi, Radix Ophiopogonis, Cortex erythrinae, Herba Agrimoniae, Herba Selaginellae, Rhizoma Imperatae, Caulis Lonicerae parasitism.Radix berchemiae lineatae antitussive hemostasis in side; Herba Ardisiae Japonicae relieving cough and resolving phlegm; Herba Houttuyniae heat-clearing and toxic substances removing; The lung moistening of Millettia Speciosa tonify deficiency; Radix Abelmoschi Sagittifolii nourishing YIN and clearing away heat; Rhizoma disporopsis pernyi nourishing YIN and moistening the lung, promoting the production of body fluid to quench thirst; Herba Ecliptae nourishing the liver and kidney, control hematemesis and epistaxis; Radix Asparagi, nourishing YIN to relieve dryness Radix Ophiopogonis, lung heat clearing is promoted the production of body fluid; Cortex erythrinae dispelling wind and removing obstruction in the collateral; Herba Agrimoniae astringing to arrest bleeding; Herba Selaginellae promoting blood circulation to restore menstrual flow; Rhizoma Imperatae cooling blood for hemostasis; Caulis Lonicerae parasitic wind and heat dispersing, subduing swelling and detoxicating.Full side works in coordination with mutually, has the effect of nourishing YIN and moistening the lung, nourishing YIN and clearing away heat, has good therapeutic effect to pulmonary tuberculosis.
One provided by the invention is treated phthisical Chinese medicine composition and is had the following advantages:
1, composite preparation provided by the invention is safe and effective, has the effect of nourishing YIN and moistening the lung, nourishing YIN and clearing away heat, has good therapeutic effect to pulmonary tuberculosis.
2, prove through clinical trial, patient, after traditional Chinese medicine composition for treating of the present invention, is 94.34% to phthisical effective percentage, and significantly can improve various phthisical clinical symptoms.
3, Chinese medicinal composition preparation provided by the invention, scientific formulation is reasonable, and technique is simple, and mouthfeel is good, and cost is low.
Detailed description of the invention
The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are for illustration of the present invention instead of limitation of the present invention.Essence according to the present invention all belongs to the scope of protection of present invention to the simple modifications that the present invention carries out.Except as otherwise noted, the percent of the amount of alcohol in the present invention is percentage by volume, and v/v represents the volume ratio of solution.
Embodiment 1 tablet
Take Radix berchemiae lineatae 3kg, Herba Ardisiae Japonicae 2.5kg, Herba Houttuyniae 1.5kg, Millettia Speciosa 2.5kg, Radix Abelmoschi Sagittifolii 2kg, Rhizoma disporopsis pernyi 1.5kg, Herba Ecliptae 2kg, Radix Asparagi 0.5kg, Radix Ophiopogonis 0.5kg, Cortex erythrinae 1.5kg, Herba Agrimoniae 0.5kg, Herba Selaginellae 0.3kg, Rhizoma Imperatae 1kg, the parasitic 1.5kg of Caulis Lonicerae.Extracting in water 3 times, three amount of water are respectively 12 times, 8 times, 6 times of medical material gross weight, three extraction times are respectively 3 hours, 2 hours, 1 hour, merge extractive liquid, filter, when filtrate is concentrated into 70 DEG C, relative density is the clear paste of 1.25, adds supplementary product starch, ethanol, Pulvis Talci, obtained tablet.
Embodiment 2 tablet
Take Radix berchemiae lineatae 5kg, Herba Ardisiae Japonicae 5kg, Herba Houttuyniae 2.5kg, Millettia Speciosa 5kg, Radix Abelmoschi Sagittifolii 3kg, Rhizoma disporopsis pernyi 2.5kg, Herba Ecliptae 4kg, Radix Asparagi 1.5kg, Radix Ophiopogonis 1.5kg, Cortex erythrinae 2.5kg, Herba Agrimoniae 1.5kg, Herba Selaginellae 1.2kg, Rhizoma Imperatae 3kg, the parasitic 3kg of Caulis Lonicerae.With 40% alcohol reflux 3 times, each ethanol consumption is respectively 10 times, 8 times, 4 times of medical material total amount, 3 hours, 2 hours, 1 hour respectively extraction time, merge extractive liquid, filter, when filtrate concentrates 60 DEG C, relative density is the extractum of 1.25, adds supplementary product starch, ethanol, Pulvis Talci, obtained tablet.
Embodiment 3 granule
Take Radix berchemiae lineatae 3.5kg, Herba Ardisiae Japonicae 3kg, Herba Houttuyniae 1.8kg, Millettia Speciosa 3kg, Radix Abelmoschi Sagittifolii 2.3kg, Rhizoma disporopsis pernyi 1.8kg, Herba Ecliptae 2.5kg, Radix Asparagi 0.8kg, Radix Ophiopogonis 0.8kg, Cortex erythrinae 1.8kg, Herba Agrimoniae 0.8kg, Herba Selaginellae 0.5kg, Rhizoma Imperatae 1.5kg, the parasitic 2kg of Caulis Lonicerae.Extracting in water 3 times, three amount of water are equivalent to 12 times, 8 times, 6 times of medical material gross weight respectively, 3 hours, 2 hours, 1 hour respectively each extraction time, merge extractive liquid, filter, when filtrate is concentrated into 70 DEG C, relative density is the clear paste of 1.20, adds ethanol, alcohol content is made to be 40%, leave standstill 24 hours, filter, it is the extractum of 1.10 that filtrate is concentrated into relative density when filtrate is concentrated into 70 DEG C, add starch, dextrin, granulate, dry, granulate and get final product.
Embodiment 4 capsule
Take Radix berchemiae lineatae 4.5kg, Herba Ardisiae Japonicae 4kg, Herba Houttuyniae 2.3kg, Millettia Speciosa 4kg, Radix Abelmoschi Sagittifolii 2.8kg, Rhizoma disporopsis pernyi 2.3kg, Herba Ecliptae 3.5kg, Radix Asparagi 1.2kg, Radix Ophiopogonis 1.2kg, Cortex erythrinae 2.3kg, Herba Agrimoniae 1.2kg, Herba Selaginellae 1kg, Rhizoma Imperatae 2.5kg, the parasitic 2.5kg of Caulis Lonicerae.With alcohol reflux 2 times, each concentration of alcohol is respectively 80%, 60%, each ethanol consumption is respectively 10 times, 8 times of medical material total amount, extraction time is respectively 4 hours, 3 hours, merge extractive liquid, filters, and when filtrate is concentrated into 80 DEG C, relative density is the extractum of 1.10, in extractum, add supplementary product starch, ethanol, dextrin, magnesium stearate, make capsule according to a conventional method.
Embodiment 5 oral liquid
Take Radix berchemiae lineatae 4kg, Herba Ardisiae Japonicae 3.5kg, Herba Houttuyniae 2kg, Millettia Speciosa 3.5kg, Radix Abelmoschi Sagittifolii 2.5kg, Rhizoma disporopsis pernyi 2kg, Herba Ecliptae 3kg, Radix Asparagi 1kg, Radix Ophiopogonis 1kg, Cortex erythrinae 2kg, Herba Agrimoniae 1kg, Herba Selaginellae 0.8kg, Rhizoma Imperatae 2kg, the parasitic 2.3kg of Caulis Lonicerae.Extracting in water 2 times, twice amount of water is respectively 10 times, 8 times of medical material gross weight, the extracted twice time is respectively 2 hours, 1 hour, merge extractive liquid, filter, when filtrate is concentrated into 80 DEG C, relative density is the extractum of 1.10, adds adjuvant mannitol, sorbic acid, water stirs in extractum, subpackage, obtained oral liquid.
Embodiment 6 granule
Take Radix berchemiae lineatae 3.2kg, Herba Ardisiae Japonicae 2.8kg, Herba Houttuyniae 1.8kg, Millettia Speciosa 2.8kg, Radix Abelmoschi Sagittifolii 2.3kg, Rhizoma disporopsis pernyi 1.8kg, Herba Ecliptae 2.3kg, Radix Asparagi 0.8kg, Radix Ophiopogonis 1.2kg, Cortex erythrinae 1.8kg, Herba Agrimoniae 0.8kg, Herba Selaginellae 0.5kg, Rhizoma Imperatae 1.2kg, the parasitic 1.8kg of Caulis Lonicerae.Extracting in water 2 times, each amount of water is equivalent to 12 times, 10 times of medical material gross weight respectively, and each extraction time is respectively 3 hours, 2 hours, merge extractive liquid, filter, it is the clear paste of 1.05 that filtrate is concentrated into relative density at 80 DEG C, adds ethanol, alcohol content is made to be 70%, leave standstill 12 hours, filter, when filtrate is concentrated into 70 DEG C, relative density is the extractum of 1.25, add starch, dextrin, granulate, dry, granulate and get final product.
Embodiment 7 syrup
Take Radix berchemiae lineatae 3.8kg, Herba Ardisiae Japonicae 3.2kg, Herba Houttuyniae 2kg, Millettia Speciosa 3.2kg, Radix Abelmoschi Sagittifolii 2.5kg, Rhizoma disporopsis pernyi 2kg, Herba Ecliptae 2.5kg, Radix Asparagi 1.2kg, Radix Ophiopogonis 0.8kg, Cortex erythrinae 2kg, Herba Agrimoniae 1kg, Herba Selaginellae 0.4kg, Rhizoma Imperatae 1.5kg, the parasitic 2kg of Caulis Lonicerae.Extracting in water 2 times, twice amount of water is respectively 10 times, 8 times of medical material gross weight, and the extracted twice time is respectively 2 hours, 1 hour, merge extractive liquid, filters, and when filtrate is concentrated into 80 DEG C, relative density is the extractum of 1.10.In extractum, add syrup adjuvant sucrose, sorbic acid, water stirs, obtained syrup.
Embodiment 8 mixture
Take Radix berchemiae lineatae 4.2kg, Herba Ardisiae Japonicae 3.8kg, Herba Houttuyniae 2.3kg, Millettia Speciosa 3.8kg, Radix Abelmoschi Sagittifolii 2.8kg, Rhizoma disporopsis pernyi 2.3kg, Herba Ecliptae 3.2kg, Radix Asparagi 1kg, Radix Ophiopogonis 0.8kg, Cortex erythrinae 2.3kg, Herba Agrimoniae 1.2kg, Herba Selaginellae 1kg, Rhizoma Imperatae 2.8kg, the parasitic 2.8kg of Caulis Lonicerae.Extracting in water 3 times, three amount of water are equivalent to 12 times, 8 times, 6 times of medical material gross weight respectively, 3 hours, 2 hours, 1 hour respectively each extraction time, merge extractive liquid, filter, filtrate is concentrated into 3 times that gross weight is medical material gross weight, fill, add mixture adjuvant sucrose, ethyl ester, water, sorbic acid stir, obtained mixture.
Embodiment 9 powder
Take Radix berchemiae lineatae 4.8kg, Herba Ardisiae Japonicae 4.5kg, Herba Houttuyniae 2.5kg, Millettia Speciosa 4.2kg, Radix Abelmoschi Sagittifolii 3kg, Rhizoma disporopsis pernyi 2.5kg, Herba Ecliptae 3.8kg, Radix Asparagi 1.5kg, Radix Ophiopogonis 1.2kg, Cortex erythrinae 2.5kg, Herba Agrimoniae 1.5kg, Herba Selaginellae 0.6kg, Rhizoma Imperatae 2kg, the parasitic 2.8kg of Caulis Lonicerae.Pulverize, sieve, to obtain final product.
clinical trial
one, to phthisical clinical observation
1 diagnostic criteria
1.1 Western medicine diagnose standards: with reference to phthisiology branch of Chinese Medical Association " diagnosis of pulmonary tuberculosis and treatment guidelines ".
1.2 Syndrome Differentiation of Traditional Chinese Medicines: with reference to " tcm internal medicine commonly encountered diseases practice guidelines " and " tcm clinical practice diagnosis term Diagnostic Division divides ".
2 inclusion criterias
1. meet at the beginning of doctor trained in Western medicine and control secondary pulmonary tuberculosis diagnostic criteria; 2. traditional Chinese medical science deficiency of lung-YIN, hyperactivity of fire caused by deficiency of YIN, the dialectical standard of syndrome of deficiency of both qi and yin is met; 3. person patient all rabat confirm there is active tuberculosis pathological changes in lung; 4. 18 ~ 60 years old age; 5. hepatic and renal function is normal, fasting glucose <6.0mmoL/L.
3 discharge standard
1. above-mentioned inclusive criteria person is not met; 2. allergic constitution or have allergy sufferers to any one medicine in scheme; 3. liver, kidney, metabolism, autoimmune disease is merged, endocrine, blood, nervous system disease, malignant tumor, long-term taking immunosuppressant patient; 4. gestation or women breast-feeding their children, psychotic etc.; 5. the cavernous changer of chronic fibro.
4 physical data
Select just to control pulmonary tuberculosis 98 example according to inclusion criteria, be divided into treatment group and matched group 2 groups at random, treatment group 53 example, matched group 45 example.Treatment group and matched group distribute in sex, age, focus scope, cavity, differential diagnosis in tcm, TCM syndrome integration no significant difference (P>0.05), have comparability between two groups.
5 Therapeutic Method
Matched group: oral isoniazid 0.3g/ time, 1 time/d; Rifampicin 0.45g/ time (body weight < 60kg), 0.6g/ (body weight >=60kg) 1 time/d; Pyrazinamide 1.5g/ time, 1 time/d; Ethambutol 0.75g/ time (body weight < 67kg), 1.0g/ (body weight >=67kg) 1 time/d.
Treatment group: give the embodiment of the present invention 5 oral liquid, 20ml/ time, 3 times/d.
6 observation index
With reference to " Chinese medical disease Standardization of diagnosis and curative effect ", the General Symptomies such as local symptom and hectic fever, night sweat, heating, inappetence, fatigue and weakness such as the cough of observation tcm syndrome, expectoration, spitting of blood, chest pain, tachypnea, medication is front and respectively record 1 time for after treating 2,4,6 months.
7 curative effect determinate standards
Cure: clinical symptoms, sign disappear or substantially disappear; Effective: clinical symptoms, sign are obviously improved; Effective: clinical symptoms, sign all take a favorable turn; Invalid: clinical symptoms, sign are not improved, even increase the weight of.
8 results
Two groups of Clinical efficacy comparisons the results are shown in Table 1.
Table 1 liang group Clinical efficacy comparison
| Group | n | Cure | Effective | Effectively | Invalid | Total effective rate (%) |
| Treatment group | 53 | 23 | 19 | 8 | 3 | 94.34 * |
| Matched group | 45 | 10 | 13 | 12 | 10 | 77.78 |
Note, compared with matched group, * P < 0.05.
As shown in Table 1, after the treatment of 2 courses for the treatment of, the embodiment of the present invention 5 is 94.34% to phthisical effective percentage, and there were significant differences compared with matched group, and significantly can improve various phthisical clinical symptoms.Result shows: Chinese medicine composition of the present invention has good therapeutical effect to pulmonary tuberculosis.
model case
Wei XX, man, 45 years old.Because of pharyngalgia, tussicula 1 week, without heating.Erythrocyte sedimentation rate (ESR) 19mm/1h.Expectorant looks for acid-fast bacilli 6 times (-).Sputum bacterial culture: 3 results are mucositis Blanc Chinese bacterium, α-hemolytic streptococcus; 3 results are pseudomonas aeruginosa.Expectorant fungal culture 3 times (-).Phlegm cytology checking 6 times (-).Clap rabat to examine as " infiltrative pulmonary tuberculosis ".Give the embodiment of the present invention 4 capsule for treating 3 months, then film making checks the calcification of tuberculosis position.
Although above with general explanation, detailed description of the invention and test, the present invention is described in detail, and on basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the scope of protection of present invention.
Claims (8)
1. treat a phthisical Chinese medicine composition, it is characterized in that it is made up of the raw material comprising following weight portion:
Radix berchemiae lineatae 30-50 part, Herba Ardisiae Japonicae 25-50 part, Herba Houttuyniae 15-25 part, Millettia Speciosa 25-50 part, Radix Abelmoschi Sagittifolii 20-30 part, Rhizoma disporopsis pernyi 15-25 part, Herba Ecliptae 20-40 part, Radix Asparagi 5-15 part, Radix Ophiopogonis 5-15 part, Cortex erythrinae 15-25 part, Herba Agrimoniae 5-15 part, Herba Selaginellae 3-12 part, Rhizoma Imperatae 10-30 part, the parasitic 15-30 part of Caulis Lonicerae.
2. the phthisical Chinese medicine composition for the treatment of as claimed in claim 1, is characterized in that it is made up of the raw material comprising following weight portion:
Radix berchemiae lineatae 35-45 part, Herba Ardisiae Japonicae 30-40 part, Herba Houttuyniae 18-23 part, Millettia Speciosa 30-40 part, Radix Abelmoschi Sagittifolii 23-28 part, Rhizoma disporopsis pernyi 18-23 part, Herba Ecliptae 25-35 part, Radix Asparagi 8-12 part, Radix Ophiopogonis 8-12 part, Cortex erythrinae 18-23 part, Herba Agrimoniae 8-12 part, Herba Selaginellae 5-10 part, Rhizoma Imperatae 15-25 part, the parasitic 20-25 part of Caulis Lonicerae.
3. the phthisical Chinese medicine composition for the treatment of as claimed in claim 1, is characterized in that it is made up of the raw material comprising following weight portion:
Radix berchemiae lineatae 40 parts, Herba Ardisiae Japonicae 35 parts, Herba Houttuyniae 20 parts, Millettia Speciosa 35 parts, Radix Abelmoschi Sagittifolii 25 parts, Rhizoma disporopsis pernyi 20 parts, Herba Ecliptae 30 parts, Radix Asparagi 10 parts, Radix Ophiopogonis 10 parts, Cortex erythrinae 20 parts, Herba Agrimoniae 10 parts, Herba Selaginellae 8 parts, Rhizoma Imperatae 20 parts, parasitic 23 parts of Caulis Lonicerae.
4. the phthisical Chinese medicine composition of the treatment as described in any one of claim 1-3, is characterized in that its active component adopts the ethanol extraction of water extraction or 40-80% concentration expressed in percentage by volume to be prepared from.
5. the phthisical Chinese medicine composition for the treatment of as claimed in claim 4, it is characterized in that its active component is prepared from by the following method: get whole 14 taste medical materials, extracting in water 2-3 time after mixing, each amount of water is equivalent to the 6-12 of medical material gross weight doubly, each extraction time is 1-3 hour, merge extractive liquid, filters, when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.15-1.20, obtains active component.
6. the phthisical Chinese medicine composition for the treatment of as claimed in claim 4, it is characterized in that its active component is prepared from by the following method: get whole 14 taste medical materials, 40-80% alcohol reflux 2-3 time is used after mixing, each ethanol consumption is 4-10 times of medical material total amount, extraction time is 1-4 hour, merge extractive liquid, filters, when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.15-1.20, obtains active component.
7. the phthisical Chinese medicine composition for the treatment of as claimed in claim 4, it is characterized in that its active component is prepared from by the following method: get whole 14 taste medical materials, extracting in water 2-3 time after mixing, each amount of water is equivalent to the 6-12 of medical material gross weight doubly, each extraction time is 1-3 hour, merge extractive liquid, filter, when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.15-1.20, add ethanol, alcohol content is made to be 40-70%, leave standstill 12-24 hour, filter, when filtrate is concentrated into 70-80 DEG C, relative density is the extractum of 1.10-1.25, obtain active component.
8. treat a phthisical Chinese medicine composition, the phthisical Chinese medicine composition of the treatment according to any one of claim 1-3 and pharmaceutically acceptable carrier combination are prepared from.
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