CN104906379A - Traditional Chinese medicine ointment for treating bullous impetigo and preparation method of ointment - Google Patents

Abstract

The invention discloses traditional Chinese medicine ointment for treating bullous impetigo and a preparation method of the ointment. The traditional Chinese medicine ointment comprises the following raw materials: blue gum, fructus forsythia, radix angelicae, herba portulacae, Chinese mahonia leaf, cortex lycii radicis, Melothria root, root of dichocarpum auriculatum, rhizoma bletillae, chamomile, trillium tschonoskii maxim, raw radix astragalis, jack fruit, pineberry, cicada slough and oblongleaf garcinia seed oil. The traditional Chinese medicine ointment provided by the invention is a pure traditional Chinese medicine preparation and is prepared by adopting an antiseptic, anti-inflammation, tissue regeneration-promoting, toxin-draining, pain-relieving, itching-relieving, heat-clearing and detoxifying method, selecting properly compatible medicine materials and using a modern advance medical and pharmaceutical technology, has good antiseptic and anti-inflammation, is safe, has no toxic or side effect, can quickly relieve itching symptoms of patients, restore the skin of the wounded part and reduce scars, can treat both symptoms and root causes of bullous impetigo, and achieves a significant curative effect.

Description

A kind ofly treat traditional Chinese herb medicine of epidermolysis pustule ulcer and preparation method thereof

Technical field

The present invention relates to the field of Chinese medicines, particularly a kind ofly treat traditional Chinese herb medicine of epidermolysis pustule ulcer and preparation method thereof.

Background technology

Pustule ulcer has another name called " infective pustule ", is commonly called as " impetigo ", is a kind of common, shallow epidermis skinfeel infectious diseases of being communicated by contact, and there is vesicle, pustule, easy ulceration knot pus crusts is feature.Different according to clinical manifestation, be divided into epidermolysis and non-impetigo bullosa two type.Wherein, impetigo bullosa is caused by staphylococcus aureus, can betide complete skin, this bacterium can produce and discharge exfoliative toxin,or exfoliatin, and exfoliative toxin,or exfoliatin is combined with the desmoglein 1 of cell surface, causes between epidermis cell and adheres to forfeiture, cell is loosened, and bulla is formed.Impetigo bullosa is apt to occur in the exposure portion such as face, extremity.From the beginning of the vesicle for being dispersed in, after 1 ~ 2 day, vesicle increases rapidly, and bleb liquid is muddy by limpid change, and pus is deposited on bottom bleb, in semilune empyema phenomenon, is one of the feature of this type impetigo.Bleb wall is thin and lax, appears rotten to the corn face after ulceration, the yellow pus crusts of knot after dry.Sometimes in the surrounding of crust, new vesicle occurs, arrangement in the form of a ring, is called ring-type impetigo.The conscious pruritus of patient is general without General Symptoms.Because the resistance of child is poor, this disease is mainly in 2-7 year child, and infectiousness is stronger, easy contagion, as process bad also can on the skin of child scar, existing Therapeutic Method many employings whole body or the antibiotic Therapeutic Method of topical, but, use antibiotic therapy, do not possess and repair the effect that skin eliminates cicatrix, can not rapid recovery patient pruritus malaise symptoms, not only can increase the occurrence probability of adverse effect, also bacterial drug resistance can be increased, child on long-term uses antibiotic also can destroy the autoimmunity of the body of child, affect the healthy of child.

Summary of the invention

The present invention improves prior art, in order to the antibiotics overcoming existing treatment epidermolysis pustule ulcer, easily to produce drug resistance, side effect large and can destroy the defect of child's autoimmunity, there is provided a kind of and treat traditional Chinese herb medicine of epidermolysis pustule ulcer and preparation method thereof, this ointment is pure Chinese medicinal preparation, use safety has no side effect, and there is good treatment bactericidal anti-inflammatory effect, can rapid recovery patient pruritis, recover illing skin, reduce the generation of cicatrix, treating both the principal and secondary aspects of a disease epidermolysis pustule ulcer, evident in efficacy.

To achieve these goals, technical scheme provided by the invention is as follows:

Treat a traditional Chinese herb medicine for epidermolysis pustule ulcer, raw material composition and the parts by weight of making described unguentum are: Eucalyptus globulus Labill 5-8 part, Fructus Forsythiae 5-8 part, Radix Angelicae Dahuricae 5-8 part, Herba Portulacae 7-10 part, Folium Mahoniae 7-10 part, Cortex Lycii 3-5 part, horse hands over youngster's root 6-8 part, sow grass 8-12 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 5-8 part, Flos Chrysanthemi 3-5 part, Rhizoma Trillii Tschonoskii 5-8 part, Radix Astragali 6-8 part, Fructus Artocarpi Heterophylli 5-8 part, Fructus Ananadis comosi certain kind of berries 5-8 part, Periostracum Cicadae 3-5 part, Olium Garciniae oblongifoliae 20-30 part.

Further, raw material composition and the parts by weight of making described unguentum are: Eucalyptus globulus Labill 5 parts, Fructus Forsythiae 5 parts, the Radix Angelicae Dahuricae 5 parts, Herba Portulacae 7 parts, Folium Mahoniae 7 parts, Cortex Lycii 3 parts, horse hands over youngster's root 6 parts, sow grass 8 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 5 parts, Flos Chrysanthemi 3 parts, Rhizoma Trillii Tschonoskii 5 parts, Radix Astragali 6 parts, Fructus Artocarpi Heterophylli 5 parts, the Fructus Ananadis comosi certain kind of berries 5 parts, Periostracum Cicadae 3 parts, Olium Garciniae oblongifoliae 20 parts.

Further, raw material composition and the parts by weight of making described unguentum are: Eucalyptus globulus Labill 8 parts, Fructus Forsythiae 8 parts, the Radix Angelicae Dahuricae 8 parts, Herba Portulacae 10 parts, Folium Mahoniae 10 parts, Cortex Lycii 5 parts, horse hands over youngster's root 8 parts, sow grass 12 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 8 parts, Flos Chrysanthemi 5 parts, Rhizoma Trillii Tschonoskii 8 parts, Radix Astragali 8 parts, Fructus Artocarpi Heterophylli 13 parts, the Fructus Ananadis comosi certain kind of berries 8 parts, Periostracum Cicadae 5 parts, Olium Garciniae oblongifoliae 30 parts.

Further, raw material composition and the parts by weight of making described unguentum are: Eucalyptus globulus Labill 7 parts, Fructus Forsythiae 7 parts, the Radix Angelicae Dahuricae 7 parts, Herba Portulacae 9 parts, Folium Mahoniae 9 parts, Cortex Lycii 4 parts, horse hands over youngster's root 7 parts, sow grass 10 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 7 parts, Flos Chrysanthemi 4 parts, Rhizoma Trillii Tschonoskii 7 parts, Radix Astragali 7 parts, Fructus Artocarpi Heterophylli 7 parts, the Fructus Ananadis comosi certain kind of berries 7 parts, Periostracum Cicadae 4 parts, Olium Garciniae oblongifoliae 25 parts.

The invention also discloses described a kind of preparation method for the treatment of the traditional Chinese herb medicine of epidermolysis pustule ulcer, comprise the following steps:

(1) Eucalyptus globulus Labill, Fructus Forsythiae, the Radix Angelicae Dahuricae, Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Astragali micronizing, crosses 1000 mesh sieves and obtains mixed-powder, for subsequent use;

(2) Herba Portulacae, Folium Mahoniae, Cortex Lycii, horse hand over youngster root, water soaking that Flos Chrysanthemi, Rhizoma Trillii Tschonoskii, Periostracum Cicadae add gross mass multiple 6 times 1 hour, and slow fire boiling 1 hour, crosses 200 order drainage screens after decocting, and it is for subsequent use to get filtrate;

(3) Fructus Artocarpi Heterophylli enucleation, Fructus Ananadis comosi certain kind of berries stalk, mixes with sow grass and cleans, and adds after the mixing of step (2) gained filtrate is squeezed the juice and leaves standstill 2 hours, cross 200 order filter screen filtration, the concentrated oven dry of gained filtrate is the concentrated solution of 1.20 ± 0.02 (60 DEG C) to relative density;

(4) in step (3), add the mixed-powder that step (1) is obtained, then add Olium Garciniae oblongifoliae and fully stir, mix homogeneously, must treat the traditional Chinese herb medicine of pustule ulcer.

The using method of this traditional Chinese herb medicine: be applied to affected part, 3 times on the one.

The present invention is in order to treat epidermolysis pustule ulcer, take anti-inflammation, granulation promoting poison holding, the method for antipruritic, the heat-clearing and toxic substances removing of pain of dispelling, while antibacterial therapy epidermolysis pustule ulcer, rapid recovery patient pruritis, the damaged skin of effective reparation patient, reduces the generation of affected part cicatrix.According to Chinese medical theory determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, screen raw material of Chinese medicine by great many of experiments, refining agent method, make each efficacy of drugs produce synergism, thus reach the effect for the treatment of both the principal and secondary aspects of a disease.In the crude drug chosen: Eucalyptus globulus Labill: micro-pungent, the micro-hardship of taste, property is put down, and dispelling wind is antipyretic, inhibiting bacteria and diminishing inflammation, anticorrosion antipruritic.For preventing influenza, epidemic cerebrospinal meningitis, control upper respiratory tract infection, pharyngolaryngitis, bronchitis, pneumonia, Acute and chronic pyelonephritis, enteritis, dysentery, filaricide, burn and scald is controlled in external, cellulitis, mastitis, furuncle and phyma, erysipelas, paddy-field dermatitis, skin eczema, tinea pedis, skin degerming; Fructus Forsythiae: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, dispelling wind and heat pathogens, modern medicine study confirms, Fructus Forsythiae concentrated decotion has antibacterial action in vitro, can suppress Bacillus typhi, Salmonella paratyphi, escherichia coli, dysentery bacterium, diphtheria corynebacterium and vibrio cholera, staphylococcus, streptococcus etc.; The Radix Angelicae Dahuricae: expelling wind and cold, understand things pain-stopping, detumescence and apocenosis, dampness leukorrhagia stopping, profit blood vessels, expelling wind and cold, eliminating dampness and dredging channels, modern medicine study confirms, the Radix Angelicae Dahuricae all has inhibitory action to escherichia coli, dysentery bacterium, Bacillus proteus, Bacillus typhi, Salmonella paratyphi, bacillus pyocyaneus, vibrio cholera, Bacillus tuberculosis etc.; Herba Portulacae: cold in nature, sweet in the mouth acid; Enter the heart, liver, spleen, large intestine channel.Have that removing dampness is antipruritic, clearing heat for detumescence, heat-clearing and toxic substances removing, diuretic dries, loose blood detumescence, dust-collection sterilization, anti-inflammatory analgetic, the effect of hemostasis removing heat from blood.Herba Portulacae has stronger inhibitory action to dysentery bacterium, Bacillus typhi and escherichia coli, can be used for the auxiliary treatment of various inflammation, have the title of " natural antibiotics ", simultaneously Herba Portulacae is also rich in vitamin C, and vitamin C has good antioxidation can whitening nourishes rough skin; Folium Mahoniae: bitter, cool, return lung, kidney channel, heat clearing away tonify deficiency, preventing phlegm from forming and stopping coughing, cures mainly hemoptysis of pulmonary tuberculosis, osteopyrexia and fever, dizziness and tinnitus, lassitude loin and legs, vexed conjunctival congestion, the diseases such as anemopyretic cold.Inhibitory action is had to staphylococcus aureus, micrococcus catarrhalis, anthrax bacillus, diphtheria corynebacterium etc.; Cortex Lycii: bitter in the mouth, cold, heat clearing away, removing heat from blood, controls asthenia hectic fever night sweat, lung-heat cough with asthma, spits blood, epistaxis, and stranguria with blood, quenches one's thirst, hypertension, carbuncle, malignant boil; Horse hands over youngster's root: sweet, bitter, cold, heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, for laryngopharynx swelling and pain, and conjunctivitis; Sore swollen toxin is controlled in external, tuberculous lymphadenitis, orchitis, skin eczema.Liver heat removing lung-heat, damp eliminating, diuresis; Sow grass: bitter in the mouth, cold in nature, removing damp-heat, detoxicating and resolving stagnation of pathogens, relieving cough and resolving phlegm, main jaundice due to damp-heat, carbuncle sore tumefacting virus, scrofula, phlegm-heat cough, epilepsy; Pseudobulbus Bletillae (Rhizoma Bletillae): bitter, sweet, cool, tonifying the lung, hemostasis, detumescence, granulation promoting, sore, control lung and hinder hemoptysis, epistaxis, incised wound is hemorrhage, swollen ulcer drug, canker sores, and soup fire is burnt, rhagadia manus et pedis; Flos Chrysanthemi: bitter in the mouth, pungent, cold nature, GUIXIN, spleen, Liver Channel, have improving eyesight, move back liver-fire, except effect of wind heat, the liver benefiting nourishing YIN; Rhizoma Trillii Tschonoskii: sweet in the mouth is micro-pungent, warm in nature, hemostasis, analgesia, granulation promoting, except rheumatism, detumescence poison, controls traumatic hemorrhage, various lumbago, impairment caused by overstrain, traumatic injury, innominate toxic swelling; Radix Astragali: sweet in the mouth, tepor, benefit defends consolidating superficial resistance, inducing diuresis to remove edema, poison holding, granulation promoting.Control spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, carbuncle is not burst or is burst and do not hold back for a long time; Fructus Artocarpi Heterophylli: have quench the thirst, lactogenesis, invigorating the spleen and replenishing QI effect, local blood circulation can be improved, to bronchitis, bronchial asthma, acute pneumonia, pharyngolaryngitis, retinitis, mastitis, puerperal engorgement of breasts, postpartum thrombophlebitis, arthritis, periarthritis, cellulitis, the disease such as ulcus cruris be all effective in cure, research finds that Fructus Artocarpi Heterophylli has antioxidation, antibacterial, antiinflammatory, adjunct antineoplastic, check melanin generate and the modern medicinal efficacy such as auxiliary hyperglycemic; The Fructus Ananadis comosi certain kind of berries: containing a kind of material being " Fructus Ananadis comosi proteinase ", Fructus Ananadis comosi proteinase can dissolve the effect of fibrin and the blood clot blocked in tissue, the blood circulation of local can be improved, diminish inflammation and edema, it is the plant that tanin content enriches, and the adsorbable absorption with stoping carcinogenic chemical, has protective effect on cancer risk in vivo, the carotene that it contains is the important substance of synthetic vitamin A, has improving eyesight nourishing the liver effect; Periostracum Cicadae: sweet in the mouth, salty, cool in nature, dispelling wind and heat pathogens, relieving sore throat to recover voice, rash, improving acuity of vision and removing nebula, endogenous wind stopping relieving convulsion, can reach skin by priming; Olium Garciniae oblongifoliae: sweet in the mouth acid, cool in nature, heat-clearing and toxic substances removing, receives sword granulation promoting, main burn, and scald, stomatitis, periodontitis, eczema, carbuncle skin ulcer is festered, the not life of new meat.

In all medicines, Eucalyptus globulus Labill, Herba Portulacae, Folium Mahoniae are monarch drug, play the effect of anti-inflammation, granulation promoting poison holding, antipruritic, the heat-clearing and toxic substances removing of pain of dispelling, for the cause of disease and the disease of epidermolysis pustule ulcer, this disease for the treatment of both the principal and secondary aspects of a disease, is killing while pathogenic bacterium effect a radical cure this disease, rapid recovery patient pruritis, repair illing skin, reduce cicatrix and produce, Fructus Forsythiae, the Radix Angelicae Dahuricae, Cortex Lycii, horse hands over youngster's root, sow grass, Pseudobulbus Bletillae (Rhizoma Bletillae), Flos Chrysanthemi, Rhizoma Trillii Tschonoskii, Radix Astragali, Olium Garciniae oblongifoliae is ministerial drug, wherein, Fructus Forsythiae, the Radix Angelicae Dahuricae, Olium Garciniae oblongifoliae can gain monarch drug Eucalyptus globulus Labill, Folium Mahoniae, the effect of Herba Portulacae anti-inflammation, effectively sterilize for the cause of disease, treatment epidermolysis pustule ulcer, Cortex Lycii, horse hands over youngster's root, sow grass, Flos Chrysanthemi, Olium Garciniae oblongifoliae can the effect of gain monarch drug Folium Mahoniae heat-clearing and toxic substances removing, the red swelling of the skin symptom that effective alleviation pustule ulcer causes, Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Trillii Tschonoskii, Radix Astragali can the effect of gain monarch drug Herba Portulacae granulation promoting poison holding, effective reparation illing skin, reduce cicatrix to produce, Fructus Artocarpi Heterophylli and the Fructus Ananadis comosi certain kind of berries are assistant, and Fructus Artocarpi Heterophylli and the Fructus Ananadis comosi certain kind of berries not only can strengthen the effect of the anti-inflammation of monarch drug and ministerial drug, also have the effect improving local blood circulation simultaneously, can increase the absorption of other drug effective ingredient, promote that the drug effect of other all medicines plays, Periostracum Cicadae, for drawing, can reach skin by priming, better treat dermatosis.Medicine of the present invention is pure Chinese medicinal preparation, and selected medical material compatibility is suitable, and adopts modern advanced medical pharmaceutical technology to make, there is treating both the principal and secondary aspects of a disease rapid-action, can effectively reduction of patient be painful, reduce cicatrix and produce, the remarkable advantage of safe without toxic side effect, is adapted to the treatment of epidermolysis pustule ulcer.

Beneficial effect of the present invention is: the invention provides and a kind ofly treat traditional Chinese herb medicine of epidermolysis pustule ulcer and preparation method thereof, take anti-inflammation, granulation promoting poison holding, pain of dispelling is antipruritic, the method of heat-clearing and toxic substances removing, adopt pure Chinese medicinal preparation, selected medical material compatibility is suitable, and adopt modern advanced medical pharmaceutical technology to make, there is treating both the principal and secondary aspects of a disease rapid-action, can effectively reduction of patient be painful, reduce cicatrix to produce, the remarkable advantage of safe without toxic side effect, the antibiotics that effectively prevent existing treatment epidermolysis pustule ulcer easily produces drug resistance, side effect is large and can destroy the defect of child's autoimmunity, use safety has no side effect, and there is good treatment bactericidal anti-inflammatory effect, can rapid recovery patient pruritis, recover illing skin, reduce the generation of cicatrix, treating both the principal and secondary aspects of a disease epidermolysis pustule ulcer, evident in efficacy.This Chinese medicinal ointment have employed the Fructus Artocarpi Heterophylli and the Fructus Ananadis comosi certain kind of berries that can improve and promote local blood circulation as adjuvant drug in the choosing of crude drug, by improving the sanguimotor method in coating position, accelerate local blood velocity, promote Transdermal absorption, make the effective ingredient of Transdermal absorption can arrive affected part with blood flow fast, promote curative effect of medication, Fructus Artocarpi Heterophylli and the Fructus Ananadis comosi certain kind of berries are as food grade materials, compared to conventional Percutaneous absorption enhancer as azone compounds, alcohol compound and dimethyl sulfoxide and homologue thereof, its to the stimulation of human body and toxic and side effects less, child uses safer.

Detailed description of the invention

According to following embodiment, the present invention may be better understood.But those skilled in the art will readily understand, concrete material proportion, process conditions and result thereof described by embodiment only should can not limit the present invention described in detail in claims yet for illustration of the present invention.

Embodiment 1

Treat a traditional Chinese herb medicine for epidermolysis pustule ulcer, raw material composition and the parts by weight of making described unguentum are: Eucalyptus globulus Labill 5 parts, Fructus Forsythiae 5 parts, the Radix Angelicae Dahuricae 5 parts, Herba Portulacae 7 parts, Folium Mahoniae 7 parts, Cortex Lycii 3 parts, horse hands over youngster's root 6 parts, sow grass 8 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 5 parts, Flos Chrysanthemi 3 parts, Rhizoma Trillii Tschonoskii 5 parts, Radix Astragali 6 parts, Fructus Artocarpi Heterophylli 5 parts, the Fructus Ananadis comosi certain kind of berries 5 parts, Periostracum Cicadae 3 parts, Olium Garciniae oblongifoliae 20 parts.

Described a kind of preparation method for the treatment of the traditional Chinese herb medicine of pustule ulcer, comprises the following steps:

(1) Eucalyptus globulus Labill, Fructus Forsythiae, the Radix Angelicae Dahuricae, Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Astragali micronizing, crosses 1000 mesh sieves and obtains mixed-powder, for subsequent use;

(2) Herba Portulacae, Folium Mahoniae, Cortex Lycii, horse hand over youngster root, water soaking that Flos Chrysanthemi, Rhizoma Trillii Tschonoskii, Periostracum Cicadae add gross mass multiple 6 times 1 hour, and slow fire boiling 1 hour, crosses 200 order drainage screens after decocting, and it is for subsequent use to get filtrate;

(3) Fructus Artocarpi Heterophylli enucleation, Fructus Ananadis comosi certain kind of berries stalk, mixes with sow grass and cleans, and adds after the mixing of step (2) gained filtrate is squeezed the juice and leaves standstill 2 hours, cross 200 order filter screen filtration, the concentrated oven dry of gained filtrate is the concentrated solution of 1.20 ± 0.02 (60 DEG C) to relative density;

(4) in step (3), add the mixed-powder that step (1) is obtained, then add Olium Garciniae oblongifoliae and fully stir, mix homogeneously, must treat the traditional Chinese herb medicine of pustule ulcer.

The using method of this traditional Chinese herb medicine: be applied on pustule ulcer, 3 times on the one.

Embodiment 2

Treat a traditional Chinese herb medicine for epidermolysis pustule ulcer, raw material composition and the parts by weight of making described unguentum are: Eucalyptus globulus Labill 8 parts, Fructus Forsythiae 8 parts, the Radix Angelicae Dahuricae 8 parts, Herba Portulacae 10 parts, Folium Mahoniae 10 parts, Cortex Lycii 5 parts, horse hands over youngster's root 8 parts, sow grass 12 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 8 parts, Flos Chrysanthemi 5 parts, Rhizoma Trillii Tschonoskii 8 parts, Radix Astragali 8 parts, Fructus Artocarpi Heterophylli 13 parts, the Fructus Ananadis comosi certain kind of berries 8 parts, Periostracum Cicadae 5 parts, Olium Garciniae oblongifoliae 30 parts.

The preparation and application of the traditional Chinese herb medicine of the treatment pustule ulcer of embodiment 2 is identical with embodiment 1.

Embodiment 3

Treat a traditional Chinese herb medicine for epidermolysis pustule ulcer, raw material composition and the parts by weight of making described unguentum are: Eucalyptus globulus Labill 7 parts, Fructus Forsythiae 7 parts, the Radix Angelicae Dahuricae 7 parts, Herba Portulacae 9 parts, Folium Mahoniae 9 parts, Cortex Lycii 4 parts, horse hands over youngster's root 7 parts, sow grass 10 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 7 parts, Flos Chrysanthemi 4 parts, Rhizoma Trillii Tschonoskii 7 parts, Radix Astragali 7 parts, Fructus Artocarpi Heterophylli 7 parts, the Fructus Ananadis comosi certain kind of berries 7 parts, Periostracum Cicadae 4 parts, Olium Garciniae oblongifoliae 25 parts.

The preparation and application of the traditional Chinese herb medicine of the treatment pustule ulcer of embodiment 3 is identical with embodiment 1.

Embodiment 4 acute dermal toxicity is tested

The traditional Chinese herb medicine of the treatment epidermolysis pustule ulcer of embodiment 1 to 3 is by Ministry of Public Health " cosmetics health specification " (2007 editions) " acute dermal toxicity once limit the quantity test method(s) " experiment, choose healthy adult rat, body weight 180 ~ 220 grams, 60, be equally divided into three groups, often organize male and female half and half, use the traditional Chinese herb medicine of embodiment 1 to 3 respectively, experiment start to shave for first 24 hours except rat trunk dorsal area by hair, do not want injured skin during unhairing in order to avoid cutaneous permeability.Painting surface amasss and accounts for 10% of rat body surface area, one time percutaneous smears dosage 5000mg/kg body weight, observe 14 days, test rat body situation, diet, drinking-water, body weight increase all normal, do not occur trembling, twitch, sialorrhea, diarrhoea, obviously intoxicating phenomenon and the phenomena of mortality such as drowsiness, stupor, place's post mortem Non Apparent Abnormality, judges that the traditional Chinese herb medicine of embodiment 1 to 3 is to the nontoxic level in the true border of rat acute percutaneous toxicity.

Embodiment 5 bacteriostatic experiment

1, experimental strain: staphylococcus aureus

2, bacterium culture medium: nutrient agar and nutrient broth medium.

3, bacteriostatic experiment divides three experimental grouies, a positive controls and negative control group, experimental group uses the traditional Chinese herb medicine for the treatment of epidermolysis pustule ulcer of the present invention, wherein, experimental group A is the ointment of gained in embodiment 1, experimental group B is the ointment of gained in embodiment 2, experimental group C is the ointment of gained in embodiment 3, and positive controls selects ciprofloxacin emulsifiable paste (the accurate word H44025085 of traditional Chinese medicines), and negative control group is blank.

4, specific experiment step:

(1) susceptibility sense sheet preparation: the round scraps of paper that diameter 6mm made by two circle board qualitative filter paper card punch put into clean dry penicillin empty bottle, bottleneck is wrapped up with monolayer kraft paper, 121 DEG C of autoclaving 30min, then through 100 DEG C of oven dry, airtightly saves backup.Aseptically respectively the scraps of paper are soaked in 2h in the ointment of embodiment 1 to 3 and ciprofloxacin emulsifiable paste, after medicinal liquid is absorbed by the scraps of paper completely, take out filter paper, it is for subsequent use that susceptibility sheet is made in 50 DEG C of oven dry, often 5 susceptibility sense sheets prepared by kind of a unguentum, prepare the scraps of paper of 5 blank sterilizings as negative control group simultaneously;

(2) prepare bacterium liquid: staphylococcus aureus strain is placed in 10ml nutrient broth medium, cultivate 18h for 37 DEG C; Get 0.9% aseptic sodium chloride solution that culture fluid 1ml adds 9ml, adopt 10 times and increase progressively dilution method, be diluted to 105 ~ 106cfu/ml, for subsequent use;

(3) the test organisms liquid that above-mentioned steps (2) is obtained is evenly inoculated on mannitol sodium chloride agar plate, left at room temperature 5min, 20 susceptibility sense sheets obtained in step (1) and 5 blank sterilizing scraps of paper are laid on this agar plate, flat board to be inverted in incubator 37 DEG C cultivate 24h after, measure the antibacterial circle diameter (mm) of each susceptibility sheet, calculate the antibacterial circle diameter meansigma methods of each group, above operation is sterile working.

5, experimental observation is measured:

Observe: represent with "-" without inhibition zone;

Antibacterial circle diameter < 10mm is slightly antibacterial, represents with "+";

Antibacterial circle diameter 10 ~ 14mm is that moderate is antibacterial, represents with " ++ ";

Antibacterial circle diameter > 14mm is highly antibacterial, represents with " +++ ";

	Negative control	Positive control	Experimental group A	Experimental group B	Experimental group C
						Inhibitory action	-	+++	+++	+++	+++

Experimental result shows, the traditional Chinese herb medicine for the treatment of epidermolysis pustule ulcer of the present invention has significant inhibitory action to staphylococcus aureus, and its effect is close with common medicine ciprofloxacin emulsifiable paste.

Embodiment 6 clinical trial:

Random selecting 400 treatment epidermolysis pustule ulcer patient carries out clinical trial, patient age 4 ~ 8 years old, average 6 years old, patients symptomatic is: the large phlysis of Semen Glycines appears in women's head-ornaments or extremity, surrounding has blush, bleb wall is thin easily breaks, and flows yellow fluid, forms erosion, conscious pruritus etc. after broken.Patient is divided into 4 groups at random, and be respectively matched group, experiment A group, experiment B group, experiment C group, each group administrations is as follows:

Matched group: give to contrast traditional Chinese herb medicine, during treatment, 3 times on the one, be applied to affected part;

Experiment A group: the traditional Chinese herb medicine giving the embodiment of the present invention 1, during treatment, 3 times on the one, is applied to affected part;

Experiment B group: the traditional Chinese herb medicine giving the embodiment of the present invention 2, during treatment, 3 times on the one, is applied to affected part;

Experiment C group: the traditional Chinese herb medicine giving the embodiment of the present invention 3, during treatment, 3 times on the one, is applied to affected part;

Wherein, the raw material making contrast traditional Chinese herb medicine consists of: Eucalyptus globulus Labill 5 parts, Fructus Forsythiae 5 parts, the Radix Angelicae Dahuricae 5 parts, Herba Portulacae 7 parts, Folium Mahoniae 7 parts, Cortex Lycii 3 parts, horse hands over youngster's root 6 parts, sow grass 8 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 5 parts, Flos Chrysanthemi 3 parts, Rhizoma Trillii Tschonoskii 5 parts, Radix Astragali 6 parts, Periostracum Cicadae 3-5 part, Olium Garciniae oblongifoliae 20-30 part.

The preparation method of matched group traditional Chinese herb medicine, comprises the following steps:

(1) Eucalyptus globulus Labill, Fructus Forsythiae, the Radix Angelicae Dahuricae, Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Astragali micronizing, crosses 1000 mesh sieves and obtains mixed-powder, for subsequent use;

(2) Herba Portulacae, Folium Mahoniae, Cortex Lycii, horse hand over youngster root, water soaking that Flos Chrysanthemi, Rhizoma Trillii Tschonoskii, Periostracum Cicadae add gross mass multiple 6 times 1 hour, and slow fire boiling 1 hour, crosses 200 order drainage screens after decocting, and it is for subsequent use to get filtrate;

(3) sow grass is clean, adds after the mixing of step (2) gained filtrate is squeezed the juice and leaves standstill 2 hours, cross 200 order filter screen filtration, and the concentrated oven dry of gained filtrate is the concentrated solution of 1.20 ± 0.02 (60 DEG C) to relative density;

(4) in step (3), add the mixed-powder that step (1) is obtained, then add Olium Garciniae oblongifoliae and fully stir, mix homogeneously, must treat the traditional Chinese herb medicine of pustule ulcer.

Therapeutic process was a course for the treatment of with 7 days, and through the treatment of a course for the treatment of, evaluate the curative effect of each group of traditional Chinese herb medicine, the standard of curative effect evaluation is:

Cure: the symptoms such as patient's impetigo all disappear, and the no positive sign of whole body can be looked into;

Take a turn for the better: impetigo is clearly better, and subjective symptoms disappears substantially;

Invalid: disease is unchanged or increase the weight of.

Statistical result is as follows:

	Matched group	Experiment A group	Experiment B group	Experiment C group
					Cure rate (%)	28	42	44	43
Improvement rate (%)	57	56	55	55
					Inefficiency (%)	15	2	1	2
Effective percentage (%)	85	98	99	98

Clinical exemplary embodiments:

1, Liu, 8 years old, man, suffer from epidermolysis pustule ulcer, there is vesicle in Head And Face and hand, vesicle mostly is Semen Glycines size, face is shown in the impetigo having 3 × 4cm, and have blush around, rotten to the corn face is scarlet, affected part pruritus, pustule place has a small amount of yellow fluid to flow out, and patient uses ciprofloxacin cream for treating 5 voluntarily, without to our hospital after positive effect, fully recover after the traditional Chinese herb medicine giving the embodiment of the present invention 2 treats a course for the treatment of, more, affected part produces without cicatrix, and drug withdrawal 1 week is without recurring.

2, Xue so-and-so, 5 years old, female, suffer from epidermolysis pustule ulcer, morbidity's seeking medical attention on the 1st, symptom be face occur several Semen Glycines size vesicle, around blush, include transparency liquid, conscious pruritus, fully recovers after the traditional Chinese herb medicine giving the embodiment of the present invention 1 treats a course for the treatment of, and drug withdrawal 1 week is without recurrence.

3, grandson so-and-so, 4 years old, man, suffer from epidermolysis pustule ulcer, morbidity's seeking medical attention on the 3rd, there is the vesicle of several Semen Glycines size in both hands elbow place, affected part pruritus is red and swollen, include transparency liquid, part ruptured blister, flows out yellow fluid, fully recovers after the traditional Chinese herb medicine giving the embodiment of the present invention 3 treats a course for the treatment of, more after, affected part produces without cicatrix, drug withdrawal nothing recurrence in 1 week.

Result shows, the traditional Chinese herb medicine for the treatment of epidermolysis pustule ulcer of the present invention, can the symptom of this disease of rapid recovery, reduce the generation of cicatrix, evident in efficacy, can safe and effective treatment epidermolysis pustule ulcer, without recurrence after curing, more after, affected part produces without cicatrix, is the medicine of desirable treatment epidermolysis pustule ulcer.

Above embodiment is only for illustrating technical conceive of the present invention and feature; its object is to allow person skilled in the art understand content of the present invention and to be implemented; can not limit the scope of the invention with this; all equivalences done according to spirit of the present invention change or modify, and all should be encompassed in protection scope of the present invention.

Claims (5)

1. treat a traditional Chinese herb medicine for epidermolysis pustule ulcer, it is characterized in that: raw material composition and the parts by weight of making described unguentum are: Eucalyptus globulus Labill 5-8 part, Fructus Forsythiae 5-8 part, Radix Angelicae Dahuricae 5-8 part, Herba Portulacae 7-10 part, Folium Mahoniae 7-10 part, Cortex Lycii 3-5 part, horse hands over youngster's root 6-8 part, sow grass 8-12 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 5-8 part, Flos Chrysanthemi 3-5 part, Rhizoma Trillii Tschonoskii 5-8 part, Radix Astragali 6-8 part, Fructus Artocarpi Heterophylli 5-8 part, Fructus Ananadis comosi certain kind of berries 5-8 part, Periostracum Cicadae 3-5 part, Olium Garciniae oblongifoliae 20-30 part.

2. a kind of traditional Chinese herb medicine for the treatment of epidermolysis pustule ulcer as claimed in claim 1, is characterized in that: raw material composition and the parts by weight of making described unguentum are: Eucalyptus globulus Labill 5 parts, Fructus Forsythiae 5 parts, the Radix Angelicae Dahuricae 5 parts, Herba Portulacae 7 parts, Folium Mahoniae 7 parts, Cortex Lycii 3 parts, horse hands over youngster's root 6 parts, sow grass 8 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 5 parts, Flos Chrysanthemi 3 parts, Rhizoma Trillii Tschonoskii 5 parts, Radix Astragali 6 parts, Fructus Artocarpi Heterophylli 5 parts, the Fructus Ananadis comosi certain kind of berries 5 parts, Periostracum Cicadae 3 parts, Olium Garciniae oblongifoliae 20 parts.

3. a kind of traditional Chinese herb medicine for the treatment of epidermolysis pustule ulcer as claimed in claim 1, is characterized in that: raw material composition and the parts by weight of making described unguentum are: Eucalyptus globulus Labill 8 parts, Fructus Forsythiae 8 parts, the Radix Angelicae Dahuricae 8 parts, Herba Portulacae 10 parts, Folium Mahoniae 10 parts, Cortex Lycii 5 parts, horse hands over youngster's root 8 parts, sow grass 12 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 8 parts, Flos Chrysanthemi 5 parts, Rhizoma Trillii Tschonoskii 8 parts, Radix Astragali 8 parts, Fructus Artocarpi Heterophylli 8 parts, the Fructus Ananadis comosi certain kind of berries 8 parts, Periostracum Cicadae 5 parts, Olium Garciniae oblongifoliae 30 parts.

4. a kind of traditional Chinese herb medicine for the treatment of epidermolysis pustule ulcer as claimed in claim 1, is characterized in that: raw material composition and the parts by weight of making described unguentum are: Eucalyptus globulus Labill 7 parts, Fructus Forsythiae 7 parts, the Radix Angelicae Dahuricae 7 parts, Herba Portulacae 9 parts, Folium Mahoniae 9 parts, Cortex Lycii 4 parts, horse hands over youngster's root 7 parts, sow grass 10 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 7 parts, Flos Chrysanthemi 4 parts, Rhizoma Trillii Tschonoskii 7 parts, Radix Astragali 7 parts, Fructus Artocarpi Heterophylli 7 parts, the Fructus Ananadis comosi certain kind of berries 7 parts, Periostracum Cicadae 4 parts, Olium Garciniae oblongifoliae 25 parts.

5. a kind of preparation method for the treatment of the traditional Chinese herb medicine of epidermolysis pustule ulcer as described in Claims 1-4, is characterized in that: comprise the following steps:

(1) Eucalyptus globulus Labill, Fructus Forsythiae, the Radix Angelicae Dahuricae, Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Astragali micronizing, crosses 1000 mesh sieves and obtains mixed-powder, for subsequent use;

(2) Herba Portulacae, Folium Mahoniae, Cortex Lycii, horse hand over youngster root, water soaking that Flos Chrysanthemi, Rhizoma Trillii Tschonoskii, Periostracum Cicadae add gross mass multiple 6 times 1 hour, and slow fire boiling 1 hour, crosses 200 order drainage screens after decocting, and it is for subsequent use to get filtrate;

(3) Fructus Artocarpi Heterophylli enucleation, Fructus Ananadis comosi certain kind of berries stalk, mixes with sow grass and cleans, and adds after the mixing of step (2) gained filtrate is squeezed the juice and leaves standstill 2 hours, cross 200 order filter screen filtration, gained filtrate is concentrated dry to relative density be 1.20 ± 0.02(60 DEG C) concentrated solution;

(4) in step (3), add the mixed-powder that step (1) is obtained, then add Olium Garciniae oblongifoliae and fully stir, mix homogeneously, must treat the traditional Chinese herb medicine of pustule ulcer.