CN104887863A - Lingual tonsilitis treatment traditional Chinese medicine spray and preparation method thereof - Google Patents

Abstract

The invention discloses a lingual tonsilitis treatment traditional Chinese medicine spray. The raw materials of the prepared spray include ligusticum wallichii, snake gall, arctium lappa, radices trichosanthis, agilawood, dried rhizome of rehmannia, eucalyptus globulus, fructus forsythiae, radix angelicae, herba portulacae, rhizoma belamcandae, gomphostemma root, honeysuckle, Dichocarpum auriculatum, chamomile, honey-fried licorice root, jackfruit and pineberry. The spray has the advantages of dispelling pathogenic wind, eliminating stagnation, clearing heat, refreshing and enriching saliva, preventing bacterial and inflammatory and relieving pain and itching, pure traditional Chinese medicines are adopted, the medicine compatibility is appropriate, the spray is prepared by the modern advanced medicine pharmaceutical technology, both the symptoms and root causes can be addressed, action is fast, pain of patients can be relieved effectively, and the spray is safe and free of toxic and side effects; the problems of treatment resistance and toxicity caused by antibiotics for treatment are avoided, body injury caused by the risk of surgery is avoided, the fast curative effect is achieved, and the recrudescence is avoided after healing.

Description

A kind of Traditional Chinese medicinal spray for the treatment of lingual tonsillitis and preparation method thereof

Technical field

The present invention relates to the field of Chinese medicines, particularly a kind of Traditional Chinese medicinal spray for the treatment of lingual tonsillitis and preparation method thereof.

Background technology

Lingual tonsillitis is the Lymph nodes of root of the tongue portion lymphoid tissue agglomerate.Be divided into acute lingual tonsillitis and chronic lingual tonsillitis.How chronic lingual tonsillitis or title lingual tonsillar hypertrophy, transfer to chronic by acute lingual tonsillitis recurrent exerbation.Acute lingual tonsillitis because of the Abwehrkraft des Koepers such as to suffer from cold, overtired reduce time, bring out primary disease.Chronic lingual tonsillitis transfers to chronic because of acute lingual tonsillitis recurrent exerbation, and upper respiratory tract chronic inflammatory disease, tobacco and wine are excessively, nice irritable food etc. makes lingual tonsil generation compensatory hypertrophy.This disease is mainly in spring and autumn, is common in teenager, and causing primarily of pathogenic bacterium blood dissolubility streptococcus, is department of otorhinolaryngology commonly encountered diseases.Chinese medicine because its shape is like nipple or Bombycis mori, therefore is called " tonsillitis ", and enter to invade lung stomach two warp mainly due to wind-heat evil toxin from mouth and nose, evil poison is fumigated and then become primary disease in throat, or lung stomach have accumulated heat, or pyretic toxicity more very, the moon of scorching hot lung stomach, deficiency of body fluid, hyperactivity of deficient fire forms, normal recurrent exerbation.There is fever and headache in acute stage in clinical manifestation, fear of cold, and child Ke Yingao is warm and cause convulsions, and pharyngalgia is obvious, and excessive saliva etc., severe patient can occur difficulty of opening one's mouth.Almond physical ability resists the antibacterial entered in nose and pharyngeal cavity under normal circumstances; human body is played a protective role; but, children's due to passive protective physical fitness low; add flu of suffering from cold; tonsil will be made to support antibacterial reduced capability, thus cause oral cavity, the antibacterial in pharyngeal, nasal cavity and the external world invades tonsil, is inflamed.The clinical manifestation of acute lingual tonsillitis is: upper respiratory tract infection symptoms, as dry pharynx, scorching hot and pharyngalgia etc.Pain increases the weight of gradually, and obvious mainly with one or both sides, root of the tongue portion, severe patient can be radiated in ear and cause severe pain, and patient is face of acute ill, occasionally has heating.The clinical manifestation of chronic lingual tonsillitis is frequent pharyngeal discomfort, foreign body sensation, dry, itch, irritable cough, the symptom such as halitosis.Mucosa acute congestion is swallowed in acute lingual tonsillitis inspection as seen, pharynx and the more sticky discharge in oral cavity, and there are ulcer and purulent secretion attachment in severe patient local, and abscess of the root of tongue can occur.There is loose lymphoid tissue in the visible root of the tongue portion of chronic lingual tonsillitis inspection, is covered with the root of the tongue in granular, and lateral symmetry or side are work.Because lingual tonsil endolymph folliculus infects, therefore under mucosa can be seen, there is yellow-white point-like microabscess.

For lingual tonsillitis, at present mainly adopt western medicine treatment, enough antibiotic are used to entire patient, have abscess person can incision and drainage, if acute attack repeatedly, after inflammation to be controlled, can excision of lingual tonsil be implemented.The treatment principle of chronic lingual tonsillitis is for removing the cause of disease and operative treatment.But antibiotic therapy, costly, and easily develops immunity to drugs, reduce resistance of human body, operative treatment is somewhat expensive not only, more can cause great injury to patient body, is not desirable therapeutic modality.Although treatment by Chinese herbs means have the advantages such as treating both the principal and secondary aspects of a disease, toxic and side effects be little, have that onset is slow, the course for the treatment of is long equally, can not rapid recovery patient suffering.

Summary of the invention

The present invention improves prior art, in order to overcome the deficiency of existing treatment means, a kind of Traditional Chinese medicinal spray for the treatment of lingual tonsillitis and preparation method thereof is provided, this spray is pure Chinese medicinal preparation, use safety has no side effect, can the pharyngeal sense of discomfort of rapid recovery patient, treating both the principal and secondary aspects of a disease lingual tonsillitis, evident in efficacy.

To achieve these goals, technical scheme provided by the invention is as follows:

Treat a Traditional Chinese medicinal spray for lingual tonsillitis, raw material composition and the parts by weight of making described Traditional Chinese medicinal spray are: Rhizoma Chuanxiong 6-8 part, Fel Serpentis 3-5 part, Fructus Arctii 7-9 part, Radix Trichosanthis 4-7 part, Lignum Aquilariae Resinatum 3-5 part, Radix Rehmanniae 5-7 part, Eucalyptus globulus Labill 8-10 part, Fructus Forsythiae 6-9 part, Radix Angelicae Dahuricae 10-13 part, Herba Portulacae 12-15 part, Rhizoma Belamcandae 4-8 part, Radix Gomphostemmae 6-8 part, Flos Lonicerae 6-8 part, sow grass 5-7 part, Flos Chrysanthemi 6-8 part, Radix Glycyrrhizae Preparata 8-10 part, Fructus Artocarpi Heterophylli 8-10 part, Fructus Ananadis comosi certain kind of berries 6-9 part.

Preferably, raw material composition and the parts by weight of making described Traditional Chinese medicinal spray are: Rhizoma Chuanxiong 6 parts, Fel Serpentis 3 parts, Fructus Arctii 7 parts, Radix Trichosanthis 4 parts, Lignum Aquilariae Resinatum 3 parts, 5 parts, the Radix Rehmanniae, Eucalyptus globulus Labill 8 parts, Fructus Forsythiae 6 parts, the Radix Angelicae Dahuricae 10 parts, Herba Portulacae 12 parts, Rhizoma Belamcandae 4 parts, Radix Gomphostemmae 6 parts, Flos Lonicerae 6 parts, sow grass 5 parts, Flos Chrysanthemi 6 parts, Radix Glycyrrhizae Preparata 8 parts, Fructus Artocarpi Heterophylli 8 parts, the Fructus Ananadis comosi certain kind of berries 6 parts.

Preferably, raw material composition and the parts by weight of making described Traditional Chinese medicinal spray are: Rhizoma Chuanxiong 8 parts, Fel Serpentis 5 parts, Fructus Arctii 9 parts, Radix Trichosanthis 7 parts, Lignum Aquilariae Resinatum 5 parts, 7 parts, the Radix Rehmanniae, Eucalyptus globulus Labill 10 parts, Fructus Forsythiae 9 parts, the Radix Angelicae Dahuricae 13 parts, Herba Portulacae 15 parts, Rhizoma Belamcandae 8 parts, Radix Gomphostemmae 8 parts, Flos Lonicerae 8 parts, sow grass 7 parts, Flos Chrysanthemi 8 parts, Radix Glycyrrhizae Preparata 10 parts, Fructus Artocarpi Heterophylli 10 parts, the Fructus Ananadis comosi certain kind of berries 9 parts.

Preferably, raw material composition and the parts by weight of making described Traditional Chinese medicinal spray are: Rhizoma Chuanxiong 7 parts, Fel Serpentis 4 parts, Fructus Arctii 8 parts, Radix Trichosanthis 6 parts, Lignum Aquilariae Resinatum 4 parts, 6 parts, the Radix Rehmanniae, Eucalyptus globulus Labill 9 parts, Fructus Forsythiae 8 parts, the Radix Angelicae Dahuricae 11 parts, Herba Portulacae 14 parts, Rhizoma Belamcandae 6 parts, Radix Gomphostemmae 7 parts, Flos Lonicerae 7 parts, sow grass 6 parts, Flos Chrysanthemi 7 parts, Radix Glycyrrhizae Preparata 9 parts, Fructus Artocarpi Heterophylli 9 parts, the Fructus Ananadis comosi certain kind of berries 7 parts.

The invention also discloses the preparation method of the Traditional Chinese medicinal spray of described treatment lingual tonsillitis, comprise the following steps:

(1) Rhizoma Chuanxiong, Fel Serpentis, Fructus Arctii, Radix Trichosanthis, Lignum Aquilariae Resinatum, the Radix Rehmanniae, Eucalyptus globulus Labill, Fructus Forsythiae, the Radix Angelicae Dahuricae, Rhizoma Belamcandae, Flos Lonicerae, Flos Chrysanthemi, Radix Glycyrrhizae Preparata are pulverized, and cross 80 mesh sieves and obtain mixed-powder, for subsequent use;

(2) distilled water that step (1) gained mixed-powder adds gross mass multiple 8 times enters immersion 1 hour, slow fire boiling 1 hour, and cross 1000 order drainage screens after decocting, gained filtrate is dried in the air cool for subsequent use to room temperature;

(3) Fructus Artocarpi Heterophylli enucleation, Fructus Ananadis comosi certain kind of berries stalk, mixes with Herba Portulacae, Radix Gomphostemmae, sow grass and cleans, add after step (2) gained filtrate is squeezed the juice and leave standstill 2 hours, cross 1000 filter screen filtration, gained filtrate is the Traditional Chinese medicinal spray for the treatment of lingual tonsillitis.

Be filled into by gained filtrate Traditional Chinese medicinal spray in order to using in the spray bottle of certain specification, the above-mentioned ownership is standby to be completed all in an aseptic environment with fill work.

The using method of this Traditional Chinese medicinal spray: this Traditional Chinese medicinal spray is injected directly in oral cavity, spray suck once dose be 100 milligrams, a spray 4 to 5 times.

The present invention is in order to treat lingual tonsillitis, and take the method that dispelling wind-evil and transforming calculus, clearing away heat and promoting production of body fluid, anti-inflammation, analgesia are antipruritic, while for cause of disease antibacterial therapy lingual tonsillitis, effective reduction of patient throat discomfort symptom, alleviates patient suffering.According to Chinese medical theory determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, screen raw material of Chinese medicine by great many of experiments, refining agent method, make each efficacy of drugs produce synergism, thus reach the effect for the treatment of both the principal and secondary aspects of a disease.In the crude drug chosen: Rhizoma Chuanxiong: pungent loose temperature is led to, can blood circulation promoting and blood stasis dispelling, again can promoting the circulation of QI to relieve pain, be " the gas medicine in blood ", the sensible QI and blood effect of tool, therefore control the breast side of body, all pains of abdominal part of qi depression to blood stasis; Fel Serpentis: Fel Serpentis has effect of heat-clearing and toxic substances removing, preventing phlegm from forming and stopping coughing, is used for the treatment of infantile cough phlegm dyspnea, pertussis, the diseases such as bronchitis; Fructus Arctii: dispelling wind and heat pathogens, lung qi dispersing rash, subduing swelling and detoxicating, controls cough due to pathogenic wind-heat, laryngopharynx swelling and pain, and macule is not saturating, and rubella is had an itch, carbuncle sore tumefacting virus; Radix Trichosanthis: clearing away heat and promoting production of body fluid, detumescence and apocenosis, for calentura excessive thirst, lung-heat type cough, interior-heat is quenched one's thirst, sore swollen toxin; Lignum Aquilariae Resinatum: temperature and not dry, row and not letting out, hold up spleen and run tireless, reach kidney and lead fire and return unit, having the merit of sending down the abnormal ascending QI, without the evil of dispelling the stagnated QI, is truly non-defective unit, dredging the meridian, and blood is capable with gas, and expectorant is with cyclostrophic, and a few genus sufferings, invariably know and heal; The Radix Rehmanniae: clearing away heat and promoting production of body fluid, removing heat from blood, hemostasis, for consumption of YIN caused by febrile disease, crimson tongue excessive thirst, sends out speckle dermexanthesis, spits blood, epistaxis, laryngopharynx swelling and pain; Eucalyptus globulus Labill: micro-pungent, the micro-hardship of taste, property is put down, and dispelling wind is antipyretic, inhibiting bacteria and diminishing inflammation, anticorrosion antipruritic.For preventing influenza, epidemic cerebrospinal meningitis, control upper respiratory tract infection, pharyngolaryngitis, bronchitis, pneumonia, Acute and chronic pyelonephritis, enteritis, dysentery, filaricide, burn and scald is controlled in external, cellulitis, mastitis, furuncle and phyma, erysipelas, paddy-field dermatitis, skin eczema, tinea pedis, skin degerming; Fructus Forsythiae: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, dispelling wind and heat pathogens, modern medicine study confirms, Fructus Forsythiae concentrated decotion has antibacterial action in vitro, can suppress Bacillus typhi, Salmonella paratyphi, escherichia coli, dysentery bacterium, diphtheria corynebacterium and vibrio cholera, staphylococcus, streptococcus etc.; The Radix Angelicae Dahuricae: expelling wind and cold, understand things pain-stopping, detumescence and apocenosis, dampness leukorrhagia stopping, profit blood vessels, expelling wind and cold, eliminating dampness and dredging channels, modern medicine study confirms, the Radix Angelicae Dahuricae all has inhibitory action to escherichia coli, dysentery bacterium, Bacillus proteus, Bacillus typhi, Salmonella paratyphi, bacillus pyocyaneus, vibrio cholera, Bacillus tuberculosis etc.; Herba Portulacae: cold in nature, sweet in the mouth acid; Enter the heart, liver, spleen, large intestine channel.Have that removing dampness is antipruritic, clearing heat for detumescence, heat-clearing and toxic substances removing, diuretic dries, loose blood detumescence, dust-collection sterilization, anti-inflammatory analgetic, the effect of hemostasis removing heat from blood.Herba Portulacae has stronger inhibitory action to dysentery bacterium, Bacillus typhi and escherichia coli, can be used for the auxiliary treatment of various inflammation, have the title of " natural antibiotics ", simultaneously Herba Portulacae is also rich in vitamin C, and vitamin C has good antioxidation can whitening nourishes rough skin; Rhizoma Belamcandae: heat-clearing and toxic substances removing, throat, expectorant saliva.Control laryngopharynx swelling and pain, abundant expectoration cough with asthma; Radix Gomphostemmae: bitter in the mouth, cool in nature, heat-clearing and toxic substances removing, relieving cough and resolving phlegm, antiinflammatory diuresis, controls pneumonia, tracheobronchitis, cough with copious phlegm, urinary tract infection, cystitis, oedema due to nephritis, lithangiuria; Flos Lonicerae: heat-clearing and toxic substances removing, wind-heat dissipating.For carbuncle furuncle, sore throat, erysipelas, warm blood fulminant dysentery, anemopyretic cold, epidemic febrile disease is generated heat; Sow grass: bitter in the mouth, cold in nature, removing damp-heat, detoxicating and resolving stagnation of pathogens, relieving cough and resolving phlegm, main jaundice due to damp-heat, carbuncle sore tumefacting virus, scrofula, phlegm-heat cough, epilepsy; Flos Chrysanthemi: bitter in the mouth, pungent, cold nature, GUIXIN, spleen, Liver Channel, have improving eyesight, move back liver-fire, except effect of wind heat, the liver benefiting nourishing YIN; Radix Glycyrrhizae Preparata: containing number of chemical compositions such as glycyrrhizin, enoxolone, Angelica Polysaccharide, there is antiinflammatory and anti-allergy action, scalable body's immunity, antitumor and analgesic effect, therefore the primary efficacy of Radix Glycyrrhizae Preparata is and middle emergency, lung moistening, removing toxic substances, coordinating the actions of various ingredients in a prescription; Fructus Artocarpi Heterophylli: have quench the thirst, lactogenesis, invigorating the spleen and replenishing QI effect, local blood circulation can be improved, to bronchitis, bronchial asthma, acute pneumonia, pharyngolaryngitis, retinitis, mastitis, puerperal engorgement of breasts, postpartum thrombophlebitis, arthritis, periarthritis, cellulitis, the disease such as ulcus cruris be all effective in cure, research finds that Fructus Artocarpi Heterophylli has antioxidation, antibacterial, antiinflammatory, adjunct antineoplastic, check melanin generate and the modern medicinal efficacy such as auxiliary hyperglycemic; The Fructus Ananadis comosi certain kind of berries: containing a kind of material being " Fructus Ananadis comosi proteinase ", Fructus Ananadis comosi proteinase can dissolve the effect of fibrin and the blood clot blocked in tissue, the blood circulation of local can be improved, diminish inflammation and edema, it is the plant that tanin content enriches, and the adsorbable absorption with stoping carcinogenic chemical, has protective effect on cancer risk in vivo, the carotene that it contains is the important substance of synthetic vitamin A, has improving eyesight nourishing the liver effect.

In all medicines, the Radix Angelicae Dahuricae, Herba Portulacae are monarch drug, for disease and the cause of disease of lingual tonsillitis, play the effect that dispelling wind-evil and transforming calculus, clearing away heat and promoting production of body fluid, anti-inflammation, analgesia are antipruritic, this disease for the treatment of both the principal and secondary aspects of a disease, is killing while pathogenic bacterium effect a radical cure this disease, the malaise symptoms such as rapid recovery is pharyngeal dryly itches, causalgia, hyperemia, Rhizoma Chuanxiong, Fel Serpentis, Fructus Arctii, Radix Trichosanthis, Lignum Aquilariae Resinatum, the Radix Rehmanniae, Eucalyptus globulus Labill, Fructus Forsythiae, Rhizoma Belamcandae, Radix Gomphostemmae, Flos Lonicerae, sow grass, Flos Chrysanthemi is ministerial drug, wherein, and Eucalyptus globulus Labill, Fructus Forsythiae, Radix Gomphostemmae can the effect of gain monarch drug anti-inflammation, effectively sterilizes for the cause of disease, treatment lingual tonsillitis, Rhizoma Chuanxiong, sow grass, Flos Chrysanthemi, Flos Lonicerae, Radix Trichosanthis, Fructus Arctii, Lignum Aquilariae Resinatum can the effect of gain monarch drug dispelling wind-evil and transforming calculus, and enter to invade lung stomach two warp for wind-heat evil toxin from mouth and nose, the cause of disease then becoming primary disease in throat fumigated by evil poison, effectively improves the symptom that the congested and purulent secretion of tonsil increases, Fel Serpentis, Eucalyptus globulus Labill, Fructus Forsythiae, Radix Gomphostemmae, sow grass, Flos Chrysanthemi, Rhizoma Belamcandae, Flos Lonicerae, the Radix Rehmanniae, Radix Trichosanthis can the effect of gain monarch drug clearing away heat and promoting production of body fluid, for accumulated heat in body, the cause of disease of hyperactivity of deficient fire, effectively removes pyretic toxicity, improves the symptom of deficiency of body fluid, alleviates dry pharynx, scorching hot, Rhizoma Chuanxiong, Lignum Aquilariae Resinatum can the antipruritic effect of gain monarch drug analgesia, for disease, effectively alleviates pharyngalgia fast, itching throat symptom, alleviates patient suffering, Fructus Artocarpi Heterophylli and the Fructus Ananadis comosi certain kind of berries are assistant, Fructus Artocarpi Heterophylli and the Fructus Ananadis comosi certain kind of berries not only can strengthen the anti-inflammation of monarch drug and ministerial drug, the effect of dispelling wind-evil and transforming calculus, also there is the effect improving local blood circulation simultaneously, the absorption of other drug effective ingredient can be increased, promote that the drug effect of other all medicines plays, Radix Glycyrrhizae Preparata for drawing, harmonizing yingfen and weifen, warming spleen and stomach for dispelling cold, simultaneously can gain monarch drug and ministerial drug anti-inflammation, clearing away heat and promoting production of body fluid effect, coordinating the actions of various ingredients in a prescription, better this disease for the treatment of.Medicine of the present invention is pure Chinese medicinal preparation, and selected medical material compatibility is suitable, and adopts modern advanced medical pharmaceutical technology to make, there is treating both the principal and secondary aspects of a disease rapid-action, can effectively reduction of patient to be painful, the remarkable advantage of safe without toxic side effect, is adapted to the treatment to lingual tonsillitis.

Beneficial effect of the present invention is: the invention provides a kind of Traditional Chinese medicinal spray for the treatment of lingual tonsillitis, take the method that dispelling wind-evil and transforming calculus, clearing away heat and promoting production of body fluid, anti-inflammation, analgesia are antipruritic, while for cause of disease antibacterial therapy lingual tonsillitis, effective reduction of patient throat discomfort symptom, alleviates patient suffering.Adopt pure Chinese medicinal preparation, selected medical material compatibility is suitable, and adopt modern advanced medical pharmaceutical technology to make, there is treating both the principal and secondary aspects of a disease rapid-action, can effectively reduction of patient be painful, the remarkable advantage of safe without toxic side effect, effectively prevent the drug resistance and toxic and side effects problem that adopt this disease of antibiotic medication to produce, avoid the risk of operative treatment and the injury to health, this Therapeutic Method curative effect is fast, not easily recurs more.

This Traditional Chinese medicinal spray have employed the Fructus Artocarpi Heterophylli and the Fructus Ananadis comosi certain kind of berries that can improve and promote local blood circulation as adjuvant drug in the choosing of crude drug, by improving the sanguimotor method in coating position, accelerate local blood velocity, promote Transdermal absorption, make the effective ingredient of Transdermal absorption can arrive affected part with blood flow fast, promote curative effect of medication, Fructus Artocarpi Heterophylli and the Fructus Ananadis comosi certain kind of berries are as food grade materials, compared to conventional Percutaneous absorption enhancer as azone compounds, alcohol compound and dimethyl sulfoxide and homologue thereof, its to the stimulation of human body and toxic and side effects less, especially for youngsters and children, use safer.

This Traditional Chinese medicinal spray is in preparation process, crude drug is pulverized in advance and decocts again, add the contact area of crude drug and water, advantageously in the extraction of effective ingredient, can make full use of crude drug, cool mixing with Fructus Artocarpi Heterophylli, the Fructus Ananadis comosi certain kind of berries etc. again to room temperature of being dried in the air by gained drug extract squeezes the juice, the effective ingredient in the medicines such as cold extraction Fructus Artocarpi Heterophylli, the vitamins and other nutritious components in Fructus Artocarpi Heterophylli and effective ingredient effectively can be avoided to be damaged in leaching process, better to ensure drug effect.

Detailed description of the invention

According to following embodiment, the present invention may be better understood.But those skilled in the art will readily understand, concrete material proportion, process conditions and result thereof described by embodiment only should can not limit the present invention described in detail in claims yet for illustration of the present invention.

Embodiment 1

Treat a Traditional Chinese medicinal spray for lingual tonsillitis, raw material composition and the parts by weight of making described Traditional Chinese medicinal spray are: Rhizoma Chuanxiong 6 parts, Fel Serpentis 3 parts, Fructus Arctii 7 parts, Radix Trichosanthis 4 parts, Lignum Aquilariae Resinatum 3 parts, 5 parts, the Radix Rehmanniae, Eucalyptus globulus Labill 8 parts, Fructus Forsythiae 6 parts, the Radix Angelicae Dahuricae 10 parts, Herba Portulacae 12 parts, Rhizoma Belamcandae 4 parts, Radix Gomphostemmae 6 parts, Flos Lonicerae 6 parts, sow grass 5 parts, Flos Chrysanthemi 6 parts, Radix Glycyrrhizae Preparata 8 parts, Fructus Artocarpi Heterophylli 8 parts, the Fructus Ananadis comosi certain kind of berries 6 parts.

The preparation method of the Traditional Chinese medicinal spray of described treatment lingual tonsillitis, comprises the following steps:

(1) Rhizoma Chuanxiong, Fel Serpentis, Fructus Arctii, Radix Trichosanthis, Lignum Aquilariae Resinatum, the Radix Rehmanniae, Eucalyptus globulus Labill, Fructus Forsythiae, the Radix Angelicae Dahuricae, Rhizoma Belamcandae, Flos Lonicerae, Flos Chrysanthemi, Radix Glycyrrhizae Preparata are pulverized, and cross 80 mesh sieves and obtain mixed-powder, for subsequent use;

(2) distilled water that step (1) gained mixed-powder adds gross mass multiple 8 times enters immersion 1 hour, slow fire boiling 1 hour, and cross 1000 order drainage screens after decocting, gained filtrate is dried in the air cool for subsequent use to room temperature;

(3) Fructus Artocarpi Heterophylli enucleation, Fructus Ananadis comosi certain kind of berries stalk, mixes with Herba Portulacae, Radix Gomphostemmae, sow grass and cleans, add after step (2) gained filtrate is squeezed the juice and leave standstill 2 hours, cross 1000 filter screen filtration, gained filtrate is the Traditional Chinese medicinal spray for the treatment of lingual tonsillitis.

Be filled into by gained filtrate Traditional Chinese medicinal spray in order to using in the spray bottle of 20 grams, the above-mentioned ownership is standby to be completed all in an aseptic environment with fill work.

The using method of this Traditional Chinese medicinal spray: this Traditional Chinese medicinal spray is injected directly in oral cavity, spray suck once dose be 100 milligrams, a spray 4 to 5 times.

Embodiment 2

Treat a Traditional Chinese medicinal spray for lingual tonsillitis, raw material composition and the parts by weight of making described Traditional Chinese medicinal spray are: Rhizoma Chuanxiong 7 parts, Fel Serpentis 4 parts, Fructus Arctii 8 parts, Radix Trichosanthis 6 parts, Lignum Aquilariae Resinatum 4 parts, 6 parts, the Radix Rehmanniae, Eucalyptus globulus Labill 9 parts, Fructus Forsythiae 8 parts, the Radix Angelicae Dahuricae 11 parts, Herba Portulacae 14 parts, Rhizoma Belamcandae 6 parts, Radix Gomphostemmae 7 parts, Flos Lonicerae 7 parts, sow grass 6 parts, Flos Chrysanthemi 7 parts, Radix Glycyrrhizae Preparata 9 parts, Fructus Artocarpi Heterophylli 9 parts, the Fructus Ananadis comosi certain kind of berries 7 parts.

The preparation method of described Traditional Chinese medicinal spray is identical with embodiment 1 with using method.

Embodiment 3

Treat a Traditional Chinese medicinal spray for lingual tonsillitis, raw material composition and the parts by weight of making described Traditional Chinese medicinal spray are: Rhizoma Chuanxiong 8 parts, Fel Serpentis 5 parts, Fructus Arctii 9 parts, Radix Trichosanthis 7 parts, Lignum Aquilariae Resinatum 5 parts, 7 parts, the Radix Rehmanniae, Eucalyptus globulus Labill 10 parts, Fructus Forsythiae 9 parts, the Radix Angelicae Dahuricae 13 parts, Herba Portulacae 15 parts, Rhizoma Belamcandae 8 parts, Radix Gomphostemmae 8 parts, Flos Lonicerae 8 parts, sow grass 7 parts, Flos Chrysanthemi 8 parts, Radix Glycyrrhizae Preparata 10 parts, Fructus Artocarpi Heterophylli 10 parts, the Fructus Ananadis comosi certain kind of berries 9 parts.

The preparation method of described Traditional Chinese medicinal spray is identical with embodiment 1 with using method.

Embodiment 4 toxicity test

According to the pertinent regulations of study of tcm new drug, toxicity test is carried out to the Traditional Chinese medicinal spray of embodiment 1 to 3, measure (LD to mouse stomach administration half till death ₅₀) carry out test determination, but LD do not detected ₅₀, carry out mtd test, result is with Cmax 50%, maximum dosage-feeding 100mg/kg, and a bu three times adopts the administration of gavage mode, successive administration 7 days, and none is dead for mice, proves avirulence of the present invention, with rat, the Traditional Chinese medicinal spray of embodiment 1 to 3 is carried out long term toxicity test, will often kind of Traditional Chinese medicinal spray respectively by Coming-of-Age Day consumption 20 times, the dose of 10 times and 5 times carries out gavage, successive administration 10 days, none is dead for rat, after 10 days, observe and detect every physiology of rat, biochemical indicator is all normal, experimental result shows: the administration of various dose, on the food-intake of rat and body weight all without impact, overt toxicity effect is not all found to the liver function of rat, to the routine blood test of rat, blood biochemistry, urine biochemistry and bone marrow sheet are showed no obvious impact, without significant difference between each group.

Embodiment 5 bacteriostatic experiment

1, experimental strain: beta hemolytic streptococcus (CICC 10373)

2, bacterium culture medium: blood plate and nutrient broth medium.

3, bacteriostatic experiment divides three experimental grouies and negative control group, and experimental group A is the Traditional Chinese medicinal spray of gained in embodiment 1, and experimental group B is the Traditional Chinese medicinal spray of gained in embodiment 2, and experimental group C is the Traditional Chinese medicinal spray of gained in embodiment 3, and negative control group is blank.

4, specific experiment step:

(1) susceptibility sense sheet preparation: the round scraps of paper that diameter 6mm made by two circle board qualitative filter paper card punch put into clean dry penicillin empty bottle, bottleneck is wrapped up with monolayer kraft paper, 121 DEG C of autoclaving 30min, then through 100 DEG C of oven dry, airtightly saves backup.Aseptically respectively the scraps of paper are soaked in 2h in the Traditional Chinese medicinal spray of embodiment 1 to 3, after medicinal liquid is absorbed by the scraps of paper completely, take out filter paper, it is for subsequent use that susceptibility sheet is made in 50 DEG C of oven dry, often 5 susceptibility sense sheets prepared by kind of a unguentum, prepare the scraps of paper of 5 blank sterilizings as negative control group simultaneously;

(2) prepare bacterium liquid: beta hemolytic streptococcus strain is placed in 10ml nutrient broth medium, cultivate 18h for 37 DEG C; Get 0.9% aseptic sodium chloride solution that culture fluid 1ml adds 9ml, adopt 10 times and increase progressively dilution method, be diluted to 105 ~ 106cfu/ml, for subsequent use;

(3) the test organisms liquid that above-mentioned steps (2) is obtained is evenly inoculated on blood plate, left at room temperature 5min, 15 susceptibility sense sheets obtained in step (1) and 5 blank sterilizing scraps of paper are laid on this blood plate, flat board to be inverted in incubator 37 DEG C cultivate 24h after, measure the antibacterial circle diameter (mm) of each susceptibility sheet, calculate the antibacterial circle diameter meansigma methods of each group, above operation is sterile working.

5, experimental observation is measured:

Observe: represent with "-" without inhibition zone;

Antibacterial circle diameter < 10mm is slightly antibacterial, represents with "+";

Antibacterial circle diameter 10 ~ 14mm is that moderate is antibacterial, represents with " ++ ";

Antibacterial circle diameter > 14mm is highly antibacterial, represents with " +++ ";

	Negative control	Experimental group A	Experimental group B	Experimental group C
					Inhibitory action	-	++	+++	++

Experimental result shows, Traditional Chinese medicinal spray of the present invention has good inhibitory action to beta hemolytic streptococcus, and the pathogenic bacterium effectively can killing lingual tonsillitis treat this disease.

Embodiment 6 clinical trial:

Random selecting 400 lingual tonsillitis patients carry out clinical trial, patient age 5-23 year, average 14 years old, patient is divided into 4 groups at random, be respectively matched group, experiment A group, experiment B group, experiment C group, medication: injected directly into by Traditional Chinese medicinal spray in oral cavity, spray suck once dose be 100 milligrams, one spray 4 to 5 times, each group administrations is as follows:

Matched group: give to contrast Traditional Chinese medicinal spray;

Experiment A group: the Traditional Chinese medicinal spray giving the embodiment of the present invention 1;

Experiment B group: the Traditional Chinese medicinal spray giving the embodiment of the present invention 2;

Experiment C group: the Traditional Chinese medicinal spray giving the embodiment of the present invention 3;

Wherein, the raw material making contrast Traditional Chinese medicinal spray consists of: Rhizoma Chuanxiong 6 parts, Fel Serpentis 3 parts, Fructus Arctii 7 parts, Radix Trichosanthis 4 parts, Lignum Aquilariae Resinatum 3 parts, 5 parts, the Radix Rehmanniae, Eucalyptus globulus Labill 8 parts, Fructus Forsythiae 6 parts, the Radix Angelicae Dahuricae 10 parts, Herba Portulacae 12 parts, Rhizoma Belamcandae 4 parts, Radix Gomphostemmae 6 parts, Flos Lonicerae 6 parts, sow grass 5 parts, Flos Chrysanthemi 6 parts, Radix Glycyrrhizae Preparata 8 parts.

The preparation method of described contrast Traditional Chinese medicinal spray, comprises the following steps:

(1) Rhizoma Chuanxiong, Fel Serpentis, Fructus Arctii, Radix Trichosanthis, Lignum Aquilariae Resinatum, the Radix Rehmanniae, Eucalyptus globulus Labill, Fructus Forsythiae, the Radix Angelicae Dahuricae, Rhizoma Belamcandae, Flos Lonicerae, Flos Chrysanthemi, Radix Glycyrrhizae Preparata are pulverized, and cross 80 mesh sieves and obtain mixed-powder, for subsequent use;

(2) distilled water that step (1) gained mixed-powder adds gross mass multiple 8 times enters immersion 1 hour, slow fire boiling 1 hour, and cross 1000 order drainage screens after decocting, gained filtrate is for subsequent use.

(3) Herba Portulacae, Radix Gomphostemmae, the mixing of sow grass are cleaned, and add after step (2) gained filtrate is squeezed the juice and leave standstill 2 hours, cross 1000 filter screen filtration, gained filtrate is contrast Traditional Chinese medicinal spray.

Be filled into by gained filtrate Traditional Chinese medicinal spray in order to using in the spray bottle of 20 grams, the above-mentioned ownership is standby to be completed all in an aseptic environment with fill work.

Therapeutic process was a course for the treatment of with 6 days, and through the treatment of a course for the treatment of, evaluate the curative effect of each group of Traditional Chinese medicinal spray, the standard of curative effect evaluation is:

Cure: all diseases of patient complete disappearance, routine blood test detects normal, and more later six months is without recurrence;

Take a turn for the better: patient condition is obviously alleviated;

Invalid: disease is unchanged or increase the weight of.

Statistical result is as follows:

	Matched group	Experiment A group	Experiment B group	Experiment C group
					Cure rate (%)	12	32	41	37
Improvement rate (%)	70	64	58	60
					Inefficiency (%)	18	4	1	3
Effective percentage (%)	82	96	99	97

Clinical exemplary embodiments:

1, grandson so-and-so, 8 years old, female, morbidity's seeking medical attention on the 2nd, symptom is that pars oralis pharyngis mucosa is obviously congested, and tonsil, pharyngopalatine arch and palatoglossal arch hyperemia are more remarkable, pharyngeal have pain sense of burning, dry pharynx, itching throat, use the Traditional Chinese medicinal spray treatment of the embodiment of the present invention 1, treatment pharyngeal congestion on the same day, dry pharynx, itching throat, causalgia symptom are obviously alleviated, after the course for the treatment of, whole disease disappears, and routine blood test detects normal, and drug withdrawal is interior without recurrence for half a year.

2, Wang, 15 years old, man, suffer from chronic lingual tonsillitis, symptom was dry pharynx, itching throat, pharyngeal causalgia, antiadoncus, air spots and surrounding tissue implication, and crypts mouth is closed, and in yellow-white point, it is stamped adhesion thing, palatoglossal arch and pharyngopalatine arch hyperemia.Use the Traditional Chinese medicinal spray treatment of the embodiment of the present invention 2, treat the 3rd day pharyngalgia, itching throat symptom and obviously alleviate, after the course for the treatment of, disease is obviously alleviated, three the course for the treatment of symptom all disappear, routine blood test detects normal, without recurring in drug withdrawal half a year.

3, Xu certain, 18 years old, man, suffer from chronic lingual tonsillitis, symptom is symptom is halitosis, dry pharynx, itching throat, pharyngeal causalgia, and when swallowing, pain sense is especially obvious, and pain can be radiated to ear, tonsil chronic congestion, tonsil air spots, with surrounding tissue implication, crypts opening part has purulent secretion, palatoglossal arch and pharyngopalatine arch hyperemia, mandibular lymph node enlargement.The Traditional Chinese medicinal spray treatment of the use embodiment of the present invention 3, treat second day dry pharynx, itching throat, causalgia symptom and obviously alleviate, after the course for the treatment of, disease is obviously alleviated, two whole disease disappearances course for the treatment of, and routine blood test detects normal, and drug withdrawal is interior without recurring for half a year.

All patients are all without bad reflection during medication, and experimental result shows, the Traditional Chinese medicinal spray for the treatment of lingual tonsillitis of the present invention, can the symptom of this disease of rapid recovery, evident in efficacy, can safe and effective healing treatment lingual tonsillitis, without recurrence after curing, it is desirable medicine.

Above embodiment is only for illustrating technical conceive of the present invention and feature; its object is to allow person skilled in the art understand content of the present invention and to be implemented; can not limit the scope of the invention with this; all equivalences done according to spirit of the present invention change or modify, and all should be encompassed in protection scope of the present invention.

Claims (5)

1. treat a Traditional Chinese medicinal spray for lingual tonsillitis, it is characterized in that: raw material composition and the parts by weight of making described Traditional Chinese medicinal spray are: Rhizoma Chuanxiong 6-8 part, Fel Serpentis 3-5 part, Fructus Arctii 7-9 part, Radix Trichosanthis 4-7 part, Lignum Aquilariae Resinatum 3-5 part, Radix Rehmanniae 5-7 part, Eucalyptus globulus Labill 8-10 part, Fructus Forsythiae 6-9 part, Radix Angelicae Dahuricae 10-13 part, Herba Portulacae 12-15 part, Rhizoma Belamcandae 4-8 part, Radix Gomphostemmae 6-8 part, Flos Lonicerae 6-8 part, sow grass 5-7 part, Flos Chrysanthemi 6-8 part, Radix Glycyrrhizae Preparata 8-10 part, Fructus Artocarpi Heterophylli 8-10 part, Fructus Ananadis comosi certain kind of berries 6-9 part.

2. a kind of Traditional Chinese medicinal spray for the treatment of lingual tonsillitis as claimed in claim 1, is characterized in that: raw material composition and the parts by weight of making described Traditional Chinese medicinal spray are: Rhizoma Chuanxiong 6 parts, Fel Serpentis 3 parts, Fructus Arctii 7 parts, Radix Trichosanthis 4 parts, Lignum Aquilariae Resinatum 3 parts, 5 parts, the Radix Rehmanniae, Eucalyptus globulus Labill 8 parts, Fructus Forsythiae 6 parts, the Radix Angelicae Dahuricae 10 parts, Herba Portulacae 12 parts, Rhizoma Belamcandae 4 parts, Radix Gomphostemmae 6 parts, Flos Lonicerae 6 parts, sow grass 5 parts, Flos Chrysanthemi 6 parts, Radix Glycyrrhizae Preparata 8 parts, Fructus Artocarpi Heterophylli 8 parts, the Fructus Ananadis comosi certain kind of berries 6 parts.

3. a kind of Traditional Chinese medicinal spray for the treatment of lingual tonsillitis as claimed in claim 1, is characterized in that: raw material composition and the parts by weight of making described Traditional Chinese medicinal spray are: Rhizoma Chuanxiong 8 parts, Fel Serpentis 5 parts, Fructus Arctii 9 parts, Radix Trichosanthis 7 parts, Lignum Aquilariae Resinatum 5 parts, 7 parts, the Radix Rehmanniae, Eucalyptus globulus Labill 10 parts, Fructus Forsythiae 9 parts, the Radix Angelicae Dahuricae 13 parts, Herba Portulacae 15 parts, Rhizoma Belamcandae 8 parts, Radix Gomphostemmae 8 parts, Flos Lonicerae 8 parts, sow grass 7 parts, Flos Chrysanthemi 8 parts, Radix Glycyrrhizae Preparata 10 parts, Fructus Artocarpi Heterophylli 10 parts, the Fructus Ananadis comosi certain kind of berries 9 parts.

4. a kind of Traditional Chinese medicinal spray for the treatment of lingual tonsillitis as claimed in claim 1, is characterized in that: raw material composition and the parts by weight of making described Traditional Chinese medicinal spray are: Rhizoma Chuanxiong 7 parts, Fel Serpentis 4 parts, Fructus Arctii 8 parts, Radix Trichosanthis 6 parts, Lignum Aquilariae Resinatum 4 parts, 6 parts, the Radix Rehmanniae, Eucalyptus globulus Labill 9 parts, Fructus Forsythiae 8 parts, the Radix Angelicae Dahuricae 11 parts, Herba Portulacae 14 parts, Rhizoma Belamcandae 6 parts, Radix Gomphostemmae 7 parts, Flos Lonicerae 7 parts, sow grass 6 parts, Flos Chrysanthemi 7 parts, Radix Glycyrrhizae Preparata 9 parts, Fructus Artocarpi Heterophylli 9 parts, the Fructus Ananadis comosi certain kind of berries 7 parts.

5. a kind of preparation method for the treatment of the Traditional Chinese medicinal spray of lingual tonsillitis as described in Claims 1-4, is characterized in that: comprise the following steps:

(1) Rhizoma Chuanxiong, Fel Serpentis, Fructus Arctii, Radix Trichosanthis, Lignum Aquilariae Resinatum, the Radix Rehmanniae, Eucalyptus globulus Labill, Fructus Forsythiae, the Radix Angelicae Dahuricae, Rhizoma Belamcandae, Flos Lonicerae, Flos Chrysanthemi, Radix Glycyrrhizae Preparata are pulverized, and cross 80 mesh sieves and obtain mixed-powder, for subsequent use;

(2) distilled water that step (1) gained mixed-powder adds gross mass multiple 8 times enters immersion 1 hour, slow fire boiling 1 hour, and cross 1000 order drainage screens after decocting, gained filtrate is dried in the air cool for subsequent use to room temperature;

(3) Fructus Artocarpi Heterophylli enucleation, Fructus Ananadis comosi certain kind of berries stalk, mixes with Herba Portulacae, Radix Gomphostemmae, sow grass and cleans, add after step (2) gained filtrate is squeezed the juice and leave standstill 2 hours, cross 1000 filter screen filtration, gained filtrate is the Traditional Chinese medicinal spray for the treatment of lingual tonsillitis.