CN101810781A - Oral spray agent for treating oral ulcers and preparation method thereof - Google Patents

Abstract

The invention relates to a preparation method of an oral spray for treating oral ulcers. The oral spray adopts the following components in parts by weight: 5-15 parts of Scutellaria baicalensis root, 5-15 parts of Gentiana baicalensis, 5-15 parts of Platycodon grandiflorum, 5-15 parts of Bletilla striata, 5-15 parts of Senecio, 5-15 parts of plantain, 5-15 parts of Aescin, 5-15 parts of clove, 5-15 parts of xugufeng, 5-15 parts of lotus leaf Mix the raw materials of the above components and add water to boil, keep the boiling time for 80-100 minutes, the weight ratio of the above-mentioned raw materials to water is 1:45-1:55, remove the residue and extract the juice to form the original drug juice, the original drug juice and distilled water according to The volume ratio is 1:1.8 to 1:2.2, mixed with each other, and after being sterilized by ultraviolet rays, it is filled into a spray bottle with a mouth. The mouth spray is easy to use and has good curative effect on oral ulcer and oral odor.

Description

A kind of preparation method of oral spray for treating oral ulcer

technical field

The invention relates to a preparation method of an oral spray for treating oral ulcers.

Background technique

Oral ulcers, also known as "oral sores", also known as recurrent aphthous ulcers, are superficial ulcers that occur on the oral mucosa. The size can range from rice grains to soybeans, and they are round or oval. 1. Peripheral hyperemia can cause pain due to irritating food, and oral ulcers recur periodically, which is medically called "recurrent oral ulcer". It is characterized by recurrent attacks, unbearable burning pain, and can cause various complications at the same time. Dialectical discussion of traditional Chinese medicine: recurrent oral ulcers, seven emotions and internal injuries, weak body, exogenous six evils, resulting in stagnation of liver and qi, stagnation of heat into fire, flaming heart fire, upward attack of stomach fire, disharmony between heart and kidney, and inflammation of deficiency fire Fumigation in the mouth and disease.

Halitosis and oral ulcers have a high incidence rate, are difficult to cure, have recurrent attacks, and have obvious symptoms. These diseases are listed by the United Nations Health Organization as one of the top ten chronic diseases of human beings in the 21st century.

Contents of the invention

The technical problem to be solved by the present invention is to provide a preparation method of an oral spray that can be used conveniently and has good curative effect for treating oral ulcers.

In order to solve the above-mentioned technical problems, the present invention adopts the following components in parts by weight: 5-15 parts of Radix Scutellariae Radix, 5-15 parts of Gentiana, 5-15 parts of Campanulaceae, 5-15 parts of Bletilla striata, 5-15 parts of Senecio, 5-15 parts of front grass, 5-15 parts of aescin, 5-15 parts of clove, 5-15 parts of xugufeng, 5-15 parts of lotus leaf; mix the raw materials of the above components and add water to boil, keep the boiling time for 80 ~100 minutes, the weight ratio of the above-mentioned raw materials to water is 1:45～1:55, remove the residue and take the juice to form the original medicine juice, the original medicine juice and distilled water are mixed according to the volume ratio of 1:1.8～1:2.2, after Fill mouth spray bottle after UV sterilization treatment.

The beneficial effects of the present invention are: the mouth spray of the present invention is a bottled liquid that is directly sprayed in the oral cavity, so as to make the breath fresh and have remarkable effects on oral ulcers caused by various reasons.

The mouth spray of the present invention adopts the combination of pure plants and the precise ratio, effectively retains the active ingredients of plants, avoids the negative effects of chemical drugs and tincture extraction, effectively expands the applicable population, and ensures the coverage of the present invention; The mouth spray does not add any chemical preservatives, and the quality assurance period is more than three years. According to clinical verification, people who use the mouth spray of the present invention can basically improve and alleviate the symptoms of oral ulcers within 6 to 12 hours; the mouth spray of the present invention External use, without any toxic and side effects, children or the elderly mistakenly swallowed without any toxic and side effects, the mouth spray of the present invention is currently the only breath freshener that adults and children can use with confidence; the mouth spray of the present invention is good for oral It is also good for bad smell and toothache.

In the oral spray medicine formula of the present invention, the effect of each crude drug is:

Scutellaria root

Contains Baicalein, Baicalin, Wogonin, Neobaicalein, etc. Experiments have proved that baicalin and baicalin have anti-allergic effects on the skin, and can effectively inhibit the edema and inflammation of the oral mucosa. Scutellaria baicalensis has a broad antibacterial spectrum. In the test tube, it has a good inhibitory effect on Shigella, Diphtheria, Pseudomonas, Staphylococcus, Streptococcus and meningococcus. Scutellaria baicalensis can still inhibit Staphylococcus aureus, which has developed resistance to antibiotics such as penicillin, and has inhibitory effect on a variety of skin pathogenic fungi. The toxicity of Scutellaria baicalensis is extremely low, and the infusion of Scutellaria baicalensis 4 grams per kilogram was fed to dogs, and no toxic reaction was seen. It is recorded in the Chinese medicine "Nihuazi Materia Medica" that Scutellaria baicalensis can "cure sores and expel pus". It is recorded in "Pearl Sac": Scutellaria baicalensis can "eliminate yang, cool the heart and remove heat, and clear the cold". Li Dongyuan: Scutellaria baicalensis "treats fever and bitter mouth".

Gentianatibetica King

Antibacterial effect: The infusion has inhibitory effects on Bacillus anthracis, Staphylococcus, Bacillus typhi, Bacillus pneumoniae, Bacillus Shigella, and Vibrio cholerae. The water infusion (1:3) has different degrees of inhibitory effects on common skin fungi in test tubes. It is recorded in "Rihuazi Materia Medica" of Chinese medicine: "Steam the main bone, treat malnutrition and timely Qi"; "Pearl Sac" records: "Treat aphthous sores".

nepeta

Leaves yellowish green, stem square with purple tinge, cross section yellowish white, tassels slightly blackish purple yellowish green. Taste flat, warm in nature, non-toxic.

bellflower

Plant, a perennial herb (Platycodon grandiforus), with ovate or ovate-lanceolate leaves, dark blue or dark purple-white flowers; it can be used as traditional Chinese medicine, the root of platycodon grandiflorum can be used as medicine, which can relieve cough, eliminate phlegm, and discharge pus, etc. Function, meridian distribution of nature and flavor: bitter, sweet, astringent, slightly cold. Return lung, liver, stomach warp.

bletilla striata

Functions and indications: Convergence and hemostasis, detumescence and granulation promoting. For hemoptysis and hematemesis, traumatic hemorrhage, sore swelling, chapped skin; pulmonary tuberculosis hemoptysis, ulcer disease hemorrhage.

Senecio

Meridian distribution of nature and flavor: cold in nature, bitter in the mouth; function cures mainly: heat-clearing and toxic substances removing, improving eyesight, relieving itching. For anemopyretic cold, conjunctival congestion and swelling pain, diarrhea and dysentery, skin eczema sore furuncle; meridian distribution of property and flavor: cold; sweet; return liver, kidney, lung, small intestine meridian.

Plantain

Function cures mainly: heat-clearing and diuretic, expectorant, cooling blood, detoxification. For edema, oliguria, hot stranguria and astringent pain, summer-heat-damp diarrhea, cough due to phlegm-heat, hematemesis and epistaxis, carbuncle and sore tumefacting virus.

Echinacea

Properties of medicinal materials: It belongs to the perennial herb of Liliaceae, and its rhizome is used as medicine, which has the effects of clearing heat and detoxifying, reducing swelling and relieving pain. Because of its good curative effect, there is a medical proverb circulating in Shangshan District, Zhejiang Province that "a single flower with seven leaves can catch the nameless swelling and poison"; the meridian distribution of property and flavor: warm; pungent; spleen, stomach, lung, and kidney meridians.

clove

Functions and indications: warming middle-JIA and lowering adverse events, invigorating kidney and yang. For spleen and stomach deficiency and cold, hiccups and vomiting, lack of appetite, vomiting and diarrhea, cold pain in trusted subordinates; meridian distribution of property and flavor: slightly fragrant gas, slightly bitter taste.

Bones

Function cures mainly: expelling wind and removing dampness, dredging collaterals to relieve pain. For rheumatic arthralgia, limb numbness and bruise pain etc. It can also be used for stomachache and toothache.

lotus leaf

Meridian distribution of property and flavor: flat; bitter; return liver, spleen, stomach meridian; function cures mainly: heat-clearing and heat-relieving, ascending hair and clearing yang, cooling blood to stop bleeding. For summer heat and polydipsia, summer-damp diarrhea, diarrhea due to spleen deficiency, vomiting of blood heat, metrorrhagia and metrorrhagia. Lotus leaf charcoal is astringent, stasis-removing and hemostasis; it is used for various hemorrhagic diseases.

The main functions of the oral spray of the present invention: the oral spray of the present invention does not contain alcohol, and its pure plant formula can effectively inhibit the pathogenic bacteria that cause oral diseases, and has the functions of clearing away heat and detoxification, relieving cough and expectorant, reducing swelling and stopping bleeding, cooling blood, and draining pus and other effects; the present invention comprehensively solves various oral discomforts such as oral ulcers, toothache, swollen gums, periodontitis, oral malodor, sore throat, dry throat, itchy throat, and foreign body sensation; the mouth spray of the present invention is safe and has no side effects Use can maintain oral health.

Adopt the clinical treatment standard of the present invention to treat oral ulcer as follows:

Use the medicine of the present invention to spray 3 to 5 times a day on the oral ulcer surface, and 15 days is a course of treatment. If the symptoms are mild, one course of treatment will relieve or heal the symptoms, and the ulcer surface will reduce and gradually heal until basically fully recovered. ~3 courses of treatment will relieve or heal the symptoms, and the ulcer surface will be reduced and gradually healed.

The effective standard is that the symptoms are relieved and the ulcer surface is reduced after 1 to 2 courses of treatment; the cured standard is that the symptoms disappear and the ulcer surface heals after 1 to 2 courses of treatment; the invalid standard is that there is no obvious ulcer after 1 to 3 courses of treatment. effect, no relief of symptoms.

From 2002 to 2009, 188 people such as Li Moumou were clinically diagnosed with oral ulcers, and obtained after clinical observation of using the mouth spray of the present invention to treat oral ulcers. The clinical experiment results were: 182 people with a total effective rate of 96.8%, the cured number is 121 people, the cure rate is 64.4%, the invalid number is 6 people, the invalid rate is 3.2%.

Typical cases:

Li Moumou, female, 17 years old, from Cangzhou City, Hebei, suffers from oral ulcers, and the symptoms disappeared completely after using the mouth spray of the present invention for 8 days in 2008.

Wang Moumou, male, 25 years old, from Qingxian County, Cangzhou City, Hebei Province, suffered from oral ulcers. After using the mouth spray of the present invention for 12 days, the symptoms disappeared completely in 2005, and there is no recurrence so far.

Liu XX, male, 33 years old, from Haixing County, Cangzhou City, Hebei Province, suffered from oral ulcers, which could not be cured for a long time. After using the mouth spray of the present invention for 20 days, the symptoms disappeared completely in 2007, and there is no recurrence so far.

Liu XX, female, 49 years old, from Xian County, Cangzhou City, Hebei Province, suffered from oral ulcers, which could not be cured for a long time. After using the mouth spray of the present invention for 33 days, the symptoms disappeared completely in 2008, and there is no recurrence so far.

Detailed ways

Example 1

A preparation method for an oral spray for the treatment of oral ulcers, characterized in that the following components are used in parts by weight:

10 parts of Scutellaria baicalensis root, 10 parts of Gentiana, 10 parts of Campanulaceae, 10 parts of Bletilla striata, 10 parts of Senecio, 10 parts of plantain, 10 parts of Aescin, 10 parts of clove, 10 parts of xugufeng, 10 parts of lotus leaf; Then it is made by selecting, dispensing, boiling, leaching, extracting juice, sterilizing, quality checking, and packaging.

The main choice of medicine is to select products with good quality raw materials, accurately dispense the medicine according to the above weight ratio, put it in a stainless steel container and add water to boil for 80 minutes. Juice, the original drug juice and distilled water are mixed according to the volume ratio of 1:2.0, and after being sterilized by ultraviolet rays, they are filled into spray bottles.

Example 2

A preparation method for an oral spray for the treatment of oral ulcers, characterized in that the following components are used in parts by weight:

5 parts of Scutellaria baicalensis root, 8 parts of Gentiana chinensis, 10 parts of bellflower, 7 parts of bletilla striata, 8 parts of Senecio, 10 parts of plantain, 5 parts of Aescin, 8 parts of clove, 14 parts of xugufeng, and 13 parts of lotus leaf. Then it is made by selecting, dispensing, boiling, leaching, extracting juice, sterilizing, quality checking, and packaging.

The main choice of medicine is to select products with good raw material quality, accurately dispense the medicine according to the above weight ratio, put it in a stainless steel container, add water and boil for 100 minutes. Juice and distilled water are mixed according to the volume ratio of 1:2.2, and after being sterilized by ultraviolet rays, they are filled into spray bottles.

Example 3

A preparation method for an oral spray for the treatment of oral ulcers, characterized in that the following components are used in parts by weight:

6 parts of Scutellaria baicalensis root, 15 parts of Gentiana chinensis, 15 parts of Campanulaceae, 15 parts of Bletilla striata, 10 parts of Senecio, 13 parts of plantain, 5 parts of Aescin, 9 parts of clove, 15 parts of xugufeng, 15 parts of lotus leaf. Then it is made by selecting, dispensing, boiling, leaching, extracting juice, sterilizing, quality checking, and packaging.

Drug selection mainly selects products with good raw material quality, accurately dispenses the medicine according to the above weight ratio, puts it in a stainless steel container, adds water and boils for 90 minutes, the weight ratio of raw materials to water is 1:55, removes the residue and extracts the juice to form the original medicine juice, the original medicine Juice and distilled water are mixed according to the volume ratio of 1:1.8, and after being sterilized by ultraviolet rays, they are filled into spray bottles.

Claims (1)

1. A preparation method for oral spray for the treatment of oral ulcer, characterized in that it adopts the following parts by weight ratio: 5-15 parts of Scutellaria baicalensis root, 5-15 parts of Gentiana, 5-15 parts of Campanulaceae, 5-15 parts of Bletilla striata, 5-15 parts of Senecio, 5-15 parts of plantain, 5-15 parts of Aescin, clove 5-15 parts, Xugufeng 5-15 parts, lotus leaf 5-15 parts; mix the raw materials of the above components and add water to boil, keep the boiling time for 80-100 minutes, the weight ratio of the above raw materials to water is 1:45-1 : 55, remove the residue and get the juice to form the original drug juice, the original drug juice and distilled water are mixed according to the volume ratio of 1: 1.8 to 1: 2.2, and after being sterilized by ultraviolet rays, they are filled into spray bottles.