CN105267678B - Chinese medicine composition for mandibular osteomyelitis - Google Patents

Abstract

The present invention relates to a kind of field of pharmaceutical formulations, specifically a kind of Chinese medicine composition for mandibular osteomyelitis, it is characterized in that, raw material forms by weight percentage are as follows: Rabdosia rubescens 9~12%, the root bark of Chinese wolf-berry 4~7%, the rhizome of davallia 3~6%, lopseed 4~6%, Japanese polygala 5~8%, spina gleditsiae 2~5%, cortex dictamni 2~4%, the root of Dahurain angelica 2~4%, bletilla 4~6%, cortex acanthopanacis 2~4%, Chinese gall 2~3%, red halloysite 4~6%, radices trichosanthis 4~6%, Asian puccoon 3~5%, asarum 1~2%, polygonum cuspidate 3~6%, Orostachys fimbriatus 2~5%, kamuning 3~5%, radix achyranthis bidentatae 3~6%, semen momordicae 0.2~1%, turtle shell 6~9%, edible tulip 2~4%, subprostrate sophora 1~3%, above-mentioned 23 taste bulk pharmaceutical chemicals are soaked in water, it removes slag after decocting to obtain filtrate.Present invention treatment mandibular osteomyelitis is without any side effects, and curative effect is high, controls difficulty in relapse after healing, has effects that clearing heat and detoxicating, activating microcirculation and removing stasis medicinal, dredging the channel, tonifying Qi and blood, resolving hard lump, detumescence and apocenosis, putrefaction-removing granulation-promoting, removing blood stasis and acesodyne.

Description

Chinese medicine composition for mandibular osteomyelitis

Technical field

The present invention relates to a kind of Chinese patent medicine preparation, specifically a kind of Chinese medicine composition for mandibular osteomyelitis.

Background technique

It is well known that mandibular osteomyelitis refers to various virulence factor invasion jawbones, causing entire bone tissue includes periosteum, bone The inflammation of cortex, marrow and blood vessel therein, nerve, motherland's medicine are known as " osteomyelitis of the maxillary bone " or " wearing the cheek ".Jawbone and whole body other The difference of bone is there is tooth in jawbone, purulent inflammation ordinary wave and jawbone caused by odontopathy, due to the infectious diseases of tooth For a kind of common disease and frequently-occurring disease, thus the disease incidence of the mandibular osteomyelitis as caused by odontopathy etc. in whole body skeletal system most It is high.Pyogenic osteomyelitis of the jaws is mostly from the odontogenic infections such as alveolar abscess, periodontitis, pericoronitis of the third molar of the mandible, secondly because crushing Property fracture or the open injuries such as firearm injury etc. cause bone wound infection, it is multiple by septicemia or septicopyemia menses infection cycle It is born in the maxilla of infant, only a few directly involves jawbone by the infection of facial skin or mucous membrane of mouth.Mandibular permanent first molar More common compared with osteomyelitis of maxilla, the state of an illness is also serious compared with osteomyelitis of maxilla, and reason is due to mandibular bone densification, surrounding There are fine and close fascia and muscle, after mandibular infection, fester is not easy to wear out drainage, and lower jaw flesh and blood transports poor, metainfective blood After pipe embolism, bulk sequestrum is easily formed.Pathogen is mainly staphylococcus aureus, is secondly streptococcus, and common is Combination Infection.By clinicopathological characteristics, lesion originates from cancellous bone and the marrow person in jawbone center, referred to as central osteomyelitis, lesion The periosteum and cortical bone person originated from around jawbone is known as marginal osteomyelitis.Acute stage and chronic can be divided by its lesion nature Phase.Topical type or diffusion-type can be divided by the range of inflammation.Clinical treatment mainly applies antibiotic so that whole body is anti-infective, locally cuts Drainage is opened, agomphiasis is pulled out or free sequestrum etc. is extractd in operation separation, protracted course of disease, patient are very painful repeatedly for the course of disease.

Summary of the invention

It is a kind of in mandibular osteomyelitis the object of the invention is in order to overcome the above-mentioned shortcomings of the prior art, provide Drug composition, at low cost, treatment mandibular osteomyelitis curative effect is high, has no toxic side effect, and has clearing heat and detoxicating, activating microcirculation and removing stasis medicinal, dredging warp Network, tonifying Qi and blood, resolving hard lump, detumescence and apocenosis, putrefaction-removing granulation-promoting, removing blood stasis and acesodyne effect.To pyogenic osteomyelitis, central, side Edge osteomyelitis acute stage, chronic phase, topical type or diffusion-type etc. have special efficacy.

The present invention solve above-mentioned technical problem the technical solution adopted is that: a kind of Chinese traditional medicine composition for mandibular osteomyelitis Object, characterized in that raw material forms by weight percentage are as follows: Rabdosia rubescens 9~12%, the root bark of Chinese wolf-berry 4~7%, the rhizome of davallia 3~6%, Lopseed 4~6%, Japanese polygala 5~8%, spina gleditsiae 2~5%, cortex dictamni 2~4%, the root of Dahurain angelica 2~4%, bletilla 4~6%, five Add skin 2~4%, Chinese gall 2~3%, red halloysite 4~6%, radices trichosanthis 4~6%, Asian puccoon 3~5%, asarum 1~2%, polygonum cuspidate 3 ~6%, Orostachys fimbriatus 2~5%, kamuning 3~5%, radix achyranthis bidentatae 3~6%, semen momordicae 0.2~1%, turtle shell 6~9%, edible tulip 2~ 4%, above-mentioned 23 taste bulk pharmaceutical chemicals are soaked in water by subprostrate sophora 1~3%, filtrate of removing slag after decocting to obtain.

The invention has the advantages that treatment mandibular osteomyelitis is without any side effects, curative effect is high, is not easy after healing multiple There is hair clearing heat and detoxicating, activating microcirculation and removing stasis medicinal, dredging the channel, tonifying Qi and blood, resolving hard lump, detumescence and apocenosis, putrefaction-removing granulation-promoting, the scattered stasis of blood to stop Pain effect has special efficacy to pyogenic osteomyelitis of the jaws etc..

Specific embodiment

The present invention will be further described with reference to the examples below:

Embodiment 1:

The present embodiment is using the Rabdosia rubescens, root bark of Chinese wolf-berry, the rhizome of davallia, lopseed, Japanese polygala, spina gleditsiae, cortex dictamni, the root of Dahurain angelica, white And cortex acanthopanacis, Chinese gall, red halloysite, radices trichosanthis, Asian puccoon, asarum, polygonum cuspidate, Orostachys fimbriatus, kamuning, radix achyranthis bidentatae, semen momordicae, turtle shell, mountain Arrowhead, subprostrate sophora are prepared as a raw material.Every pair of its component (weight %) for Rabdosia rubescens 11.1, the root bark of Chinese wolf-berry 5.6, the rhizome of davallia 4.5, Lopseed 4.8, Japanese polygala 6.6, spina gleditsiae 3.9, cortex dictamni 3.8, the root of Dahurain angelica 3.7, bletilla 5.4, cortex acanthopanacis 3.3, Chinese gall 2.2, Red halloysite 5.5, radices trichosanthis 5.1, Asian puccoon 3.3, asarum 1.2, polygonum cuspidate 5.1, Orostachys fimbriatus 3.1, kamuning 4.2, radix achyranthis bidentatae 4.1, semen momordicae 0.3, turtle shell 7.9, edible tulip 3.4, subprostrate sophora 1.9.Taking above-mentioned 23 raw material gross weights is 281 grams, first by turtle shell, red halloysite list Packet is decocted first, and 21 Chinese herbal medicines of remaininging add 900~1000ml of water, impregnates 2~3 hours.After turtle shell, red halloysite boil 30 minutes, then under It impregnates 21 Chinese herbal medicines to pour into container together with soaking water, boils decoct with slow fire to 60~80 minutes with high heat, remove slag Filtrate 200ml or so, the dregs of a decoction add water 300~400ml or so, and remove slag to obtain filtrate 100ml or so, there are 300ml or so decoction It shakes up, obtains " insulting bone gold angle soup ", be packed into sterile glass vials, seal bottle cap is spare.Daily 1 dose point 3 oral, each skies Abdomen takes 100ml or so.

Main ingredient Rabdosia rubescens test tube method experiment in vitro of the present invention proves that Rabdosia rubescens alcohol extract is to staphylococcus aureus and A type Streptococcus has obvious antibacterial action, shows stronger antibacterial to staphylococcus albus, beta streptococcus, expense Shigella flexneri and makees With also relatively strong to typhoid bacillus, shigella dysenteriae, streptococcus mutans effect.Its bitter in taste, sweet, slightly cold, return lung, stomach, Liver Channel.Tool There is clearing heat and detoxicating, promoting blood circulation and stopping pain effect, is used for abscess of throat , abdominal mass and lump, snakebite and bugbite.Root bark of Chinese wolf-berry bacteriostatic experiment: to golden yellow Color staphylococcus, typhoid bacillus, paratyphoid bacillus A etc. have stronger bacteriostasis.Nature and flavor are sweet, cold, return lung, liver, kidney Through.With cool blood except steaming, clearing lung-heat fall fire effect is used for deficiency of Yin hectic fever, hectic fever due to yin night sweat, and cough with lung heat spits blood, and bleeding from five sense organs or subcutaneous tissue, interior heat disappears Consumption.The rhizome of davallia is bitter in taste, warm, returns liver and kidney channel, has analgesic of curing the wound, and The strong bone of kidney tonifying effect is used for falling winks frustrates, and muscles and bones is sprained, Lumbago due to the kidney deficiency, muscles and bones impotence, Hiccough and deaf, tooth mobility etc..Lopseed nature and flavor acrid, bitter, warm, has relieve heat clearing damp, and removing toxic substances stops Pain effect.For rheumatic arthritis, sore swollen toxin etc. is controlled in external application.Japanese polygala nature and flavor are pungent, bitter, flat, distributed in lung channel.Stop with eliminating the phlegm Cough, activating blood circulation and reducing swelling, detoxify analgesic efficacy, is used for coughing with a lot of sputum, abscess of throat etc..Spina gleditsiae nature and flavor are pungent, warm, return liver, stomach meridian, tool Have a detumescence and poison retention, apocenosis, disinsection efficiency, for ulcer from the beginning of or purulence not at bursting etc..Cortex dictamni is bitter in taste, cold, returns spleen, stomach, wing Guang warp.With heat-clearing and damp-drying drug, wind-dispelling detoxicating functions.For damp and hot sore, yellow water is dripping, eczema, rubeola, scabies sore leprosy, rheumatism Hot numbness, jaundice and reddish urine.Root of Dahurain angelica nature and flavor are pungent, warm, return stomach, large intestine, lung channel, have relieving exterior syndrome and dispelling cold, and wind-expelling pain-stopping declares clearing the nasal passage, dry Wet stop-band, detumescence and apocenosis effect.For cold headache, pain in the supra-orbital bone, nasal congestion, allergic rhinitis, nasosinusitis, toothache, leukorrhagia, sore is swollen Bitterly.Bletilla is bitter in taste, sweet, puckery, slightly cold, return lung, liver, stomach meridian, has astringing to arrest bleeding, detumescence and promoting granulation effect.For spitting blood, spitting Blood, traumatic hemorrhage, sore swollen toxin, chapped skin.Cortex acanthopanacis nature and flavor acrid, bitter, warm, returns liver kidney channel, has dispelling wind and eliminating dampness, help liver Kidney strengthens muscles and bones, inducing diuresis for removing edema effect, is used for rheumatic arthralgia, muscles and bones impotence, asthenia, oedema etc..Chinese gall nature and flavor acid, It is puckery, cold, return lung, large intestine, kidney channel.With astringing lung-QI fall fire, relieving diarrhea with astringents, arrest sweating, hemostasis, hygroscopic sore effect.It is long for the deficiency syndrome of the lung Cough, lung feverish cough, protracted dysentery and diarrhea, spontaneous sweating are quenched one's thirst, hematochezia hemorrhoid blood, traumatic hemorrhage, carbuncle sore tumefacting virus, skin moisture fester.Red halloysite Nature and flavor are sweet, sour, puckery, warm, return large intestine, stomach meridian.With puckery intestines, hemostasis, myogenic sore effect.For protracted dysentery and diarrhea, fecal blood, Metrorrhagia and metrostaxis leukorrhagia, sore burst for a long time and does not holds back, wet sore pus contamination etc..Radices trichosanthis nature and flavor are sweet, slight bitter, slightly cold, attach to the lung and stomach meridians.With clear Hot water pouring, promotes the production of body fluid to quench thirst, detumescence and apocenosis effect.For pyreticosis and polydipsia, lung-heat type cough, Heat Diabetes, sore swollen toxin.Asian puccoon nature and flavor It is sweet, salty, cold, converge to heart and liver channels.With clearing heat and cooling blood, promoting blood circulation and detoxication, promoting eruption ecchymose removing effect.For blood-heat and toxin exuberance, atropurpureus macula, Measles without adequate eruption, sore, eczema, the long scald of water.Asarum nature and flavor are pungent, warm, return heart, lung, kidney channel.With expelling wind and clearing away cold, wind-expelling pain-stopping, It is sensible, warming lung and resolving fluid effect.For anemofrigid cold, have a headache, toothache, rheumatic arthralgia etc..It is polygonum cuspidate nature and flavor slight bitter, slightly cold, return liver, Gallbladder, lung channel.It is clearing heat and detoxicating with removing dampness through diuresis and removing jaundice, removing blood stasis and acesodyne, relieving cough and reducing sputum effect.For jaundice with damp-heat pathogen, stranguria with turbid discharge, leukorrhagia, wind Arthritis with fixed pain caused by dampness pain, carbuncle sore tumefacting virus etc..Orostachys fimbriatus nature and flavor are sour, bitter, cool, return liver, lung, the spleen channel.Have effects that cool blood, hemostasis, removing toxic substances, sore. For bloody flux, hematochezia, hemorrhoid blood, the long disunion of the open sore part.Kamuning nature and flavor are pungent, slight bitter, temperature, slightly poisonous, return liver, stomach meridian.With row Gas analgesic, promoting blood circulation to remove blood stasis effect.For having a stomachache, rheumatic arthralgia, toothache, tumbling and swelling etc..Radix achyranthis bidentatae is bitter in taste, sweet, sour, flat, returns Liver and kidney channel.With dispelling stasis of blood and stimulating the menstrual flow, nourishing liver and kidney, strengthening the bones and muscles, inducing diuresis for treating strangurtia, effect of ensurining proper downward flow of the blood.For menostasis, dysmenorrhea, waist and knee acid Bitterly, muscles and bones is powerless, oedema, has a headache, toothache, aphtha etc..Semen momordicae is bitter in taste, micro-sweet, cool, toxic, returns liver, spleen, stomach meridian.Have Mass dissipating and swelling eliminating attacks poison and treats sore effect.For sore swollen toxin, acute mastitis, scrofula etc..Turtle shell nature and flavor are salty, slightly cold, return liver and kidney channel.Have Nourishing and suppressing Yang is brought down a fever except steaming, resolving hard lump effect.For fever due to yin deficiency, hectic fever due to yin labor heat, hyperactivity of yang due to yin deficiency is had a dizzy spell, in empty wind It is dynamic, clonic convulsion of the hand and foot, menostasis , wei lump in the abdomen etc..Edible tulip nature and flavor are sweet, micro-pungent, cool, return liver, spleen, have clearing heat and detoxicating, reducing phlegm and resolving masses function Effect.For carbuncle sore tumefacting virus, scrofula productive cough, snakebite and bugbite , wei lump in the abdomen lump in the abdomen.Subprostrate sophora is bitter in taste, cold, toxic, attaches to the lung and stomach meridians, tool There is clearing heat and detoxicating, relieving sore-throat effect of reducing swelling.It is pented up for long poison, tonsillitis and larynx numbness, abscess of throat, gingivitis, aphthae.23 The ingenious prescription of Chinese herbal medicine, scientific compatibility, mutual reinforcement between mutually make compatibility, can play synergistic effect, can improve drug effect；Mutual restraint between two drugs, the mutual-detoxication are matched 5, poisonous side effect of medicine can be mitigated or eliminated.Oral medicine soup cooperates mass soak, can accelerate to remove affected part sepage, eliminate Swelling mitigates infection, promotes necrotic tissue discharge.The special efficacy for the treatment of mandibular osteomyelitis is played in the mutually coordinated effect of drug altogether.

Each bulk pharmaceutical chemicals of the present invention can also the embodiment of ratio (weight percent) listed by according to the form below mixing realize.It is processed Technique is same as Example 1.

Medicine name	Embodiment 2	Embodiment 3	Embodiment 4
				Rabdosia rubescens	11.1	10.9	10.7
The root bark of Chinese wolf-berry	5.6	6.1	5.3
				The rhizome of davallia	4.5	5.1	4.3
Lopseed	4.8	5.1	4.3
				Japanese polygala	6.6	7.4	7.1
Spina gleditsiae	3.9	4.1	3.6
				Cortex dictamni	3.8	3.3	3.6
The root of Dahurain angelica	3.7	3.1	3.6
				Bletilla	5.4	5.6	5.2
Cortex acanthopanacis	3.3	3.9	3.6
				Chinese gall	2.2	2.3	2.1
Red halloysite	5.5	5.2	5.3
				Radices trichosanthis	5.1	4.9	5.3
Asian puccoon	3.3	3.5	3.6
				Asarum	1.2	1.4	1.1
Polygonum cuspidate	5.1	4.5	5.3
				Orostachys fimbriatus	3.1	3.3	3.2
Kamuning	4.2	3.9	4.3
				Radix achyranthis bidentatae	4.1	3.8	4.3
Semen momordicae	0.3	0.2	0.4
				Turtle shell	7.9	7.1	8.5
Edible tulip	3.4	3.5	3.2
				Subprostrate sophora	1.9	1.8	2.1

Below with reference to our hospital, i.e., the clinical test that In Shandong Weihai central hospital carries out makees the present invention further detailed Ground description:

1. clinical case: selected case is in June, 2012 to the department of stomatology diagnosis and treatment of 2015 Nian9Yue Lai our hospital, according to clinical table Now and toposcopy, in conjunction with medical history, cooperate mandibular osteomyelitis 64 that X-ray film is made a definite diagnosis, male 39, female 25, age 21-65 It is year, 37 years old average, it is the course of disease 1 month to 3 years, 2 months 1 year, maxilla 19, mandibular 45 average.

2. diagnostic criteria；Chinese medicine is known as " osteomyelitis of the maxillary bone " or " wearing the cheek ", and diagnostic criteria is issued referring to State Administration of Traditional Chinese Medicine " the disease of tcm Standardization of diagnosis and curative effect " of cloth is formulated.

3. treatment method: oral " insulting bone gold angle soup " it is daily 1 dose point 3 times it is oral, 100ml or so is administered at empty stomach every time, it is oral " insulting bone gold angle soup " 10 days as one therapeutic course, interval 2 days, reapplies next course for the treatment of, is normally applied 3 courses for the treatment of.

4. therapeutic evaluation

Cure: Ipsilateral Maxillary region pain and toothache disappear, and Maxillary region swelling is subsided, and body temperature is normal, and limitation of mouth opening releases, X Line film making restores normal.

Improve: Ipsilateral Maxillary region pain and toothache are substantially reduced, and Maxillary region swelling is obviously declined, and occasionally have low-heat, x-ray film making Occasionally there is inflammatory infiltration lump.

Invalid: Clinical symptom and sign and x-ray film making are without significant change.

Curing plus improving is total effective rate.

5. therapeutic effect: using 64 mandibular osteomyelitis patients of the invention, using 3 courses for the treatment of, according to the standard of curative effect evaluation It carries out effect assessment: curing 49, account for about 76.6%；It improves 12, accounts for about 18.8%；Invalid 3, account for about 4.6%.It is total effective Rate is 95.4%.

Claims (1)

1. a kind of Chinese medicine composition for mandibular osteomyelitis, which is characterized in that bulk pharmaceutical chemicals form by weight percentage are as follows: the winter Icepro grass 9~12%, the root bark of Chinese wolf-berry 4~7%, the rhizome of davallia 3~6%, lopseed 4~6%, Japanese polygala 5~8%, spina gleditsiae 2~5%, Cortex dictamni 2~4%, the root of Dahurain angelica 2~4%, bletilla 4~6%, cortex acanthopanacis 2~4%, Chinese gall 2~3%, red halloysite 4~6%, day Pollen 4~6%, Asian puccoon 3~5%, asarum 1~2%, polygonum cuspidate 3~6%, Orostachys fimbriatus 2~5%, kamuning 3~5%, radix achyranthis bidentatae 3~ 6%, semen momordicae 0.2~1%, turtle shell 6~9%, edible tulip 2~4%, subprostrate sophora 1~3%, by the above-mentioned medicinal water of 23 taste raw material It impregnates, filtrate of removing slag after decocting to obtain.