CN114159534A - Traditional Chinese medicine composition and application for treating mesenteric lymphadenitis and preparation method thereof - Google Patents

Traditional Chinese medicine composition and application for treating mesenteric lymphadenitis and preparation method thereof Download PDF

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CN114159534A
CN114159534A CN202111260330.0A CN202111260330A CN114159534A CN 114159534 A CN114159534 A CN 114159534A CN 202111260330 A CN202111260330 A CN 202111260330A CN 114159534 A CN114159534 A CN 114159534A
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treating
mesenteric lymphadenitis
traditional chinese
chinese medicine
medicine composition
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张丰强
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Shanghai Dafangmai Institute Of Traditional Chinese Medicine Co ltd
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Shanghai Dafangmai Institute Of Traditional Chinese Medicine Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/754Evodia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/24Mucus; Mucous glands; Bursa; Synovial fluid; Arthral fluid; Excreta; Spinal fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/536Prunella or Brunella (selfheal)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/65Paeoniaceae (Peony family), e.g. Chinese peony
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8966Fritillaria, e.g. checker lily or mission bells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/906Zingiberaceae (Ginger family)
    • A61K36/9062Alpinia, e.g. red ginger or galangal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

The invention discloses a traditional Chinese medicine composition for treating mesenteric lymphadenitis, a patch and a preparation method thereof, and relates to the technical field of traditional Chinese medicines, wherein the patch is prepared from the following raw materials in parts by weight: the external application paste for treating mesenteric lymphadenitis prepared by the raw material ratio and the method has the effects of activating self-healing force of a human body, smoothing qi and blood, diminishing inflammation, resolving masses, relieving spasm, relieving pain and the like, directly reaches focus by pasting on Shenque point, has good curative effect on mesenteric lymphadenitis, and has quick response and simple use method, can overcome the defects that the oral medicine is absorbed slowly and can not directly reach the focus and the defect of single target of western medicine.

Description

Traditional Chinese medicine composition and application for treating mesenteric lymphadenitis and preparation method thereof
Technical Field
The invention relates to the technical field of acupoint application, in particular to a traditional Chinese medicine composition for treating mesenteric lymphadenitis, an application agent and a preparation method thereof.
Background
Mesenteric lymphadenitis, an inflammation of the mesenteric lymph nodes that is caused by viral and bacterial infections that typically occur in the pharynx; is commonly seen in children; may be related to the development of the children's immune system insufficiently. Since the mesentery is mainly more abundant in the distal ileum and colonic lymph nodes, at the time of upper respiratory tract infection, viruses and bacteria will reach the distal ileum and colon through the blood circulation, causing regional lymph node infection. The clinical manifestations of the disease are angina, fever and cough, and then are accompanied by abdominal pain, nausea, vomiting, diarrhea or constipation.
B ultrasonic display of abdomen: mesenteric lymphadenectasis; the abdomen has tenderness around the umbilicus, on the right side of the umbilicus and even in the lower right abdomen. It is characterized by that it is mainly used for curing viral infection, and can be naturally recovered. The disease has high incidence in children, and affects the health and growth of children patients.
The Chinese medicine acupoint application belongs to one of the Chinese medicine external treatment methods. The plaster is prepared by adopting a specific traditional Chinese medicine formula, is directly applied to human acupuncture points (the main acupuncture points are Shenque acupuncture points) to stimulate the human acupuncture points, activates the self-healing force of the human body, enables the self-healing force of the organism to play a role and achieves the purpose of treating diseases.
Modern researches show that when the acupuncture points are stimulated and the medicine permeation reaches a certain amount, the organism can generate non-specific benign stimulation to excite a physiological stress system in the organism, and the defense immune function of the organism is enhanced and the metabolism is accelerated through a series of regulation of nerve-endocrine-body fluid, so that the aim of promoting the disease to be cured is fulfilled.
Based on the problems, a traditional Chinese medicine composition for treating mesenteric lymphadenitis, a patch and a preparation method thereof are designed to solve the problems.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to provide a traditional Chinese medicine composition for treating mesenteric lymphadenitis, a patch and a preparation method thereof, and the traditional Chinese medicine composition has the advantages of activating the self-healing ability of a human body, promoting qi and blood circulation, diminishing inflammation, dissipating stagnation, relieving spasm and pain and achieving the purpose of treating mesenteric lymphadenitis.
In a first aspect, the invention discloses a traditional Chinese medicine composition for treating mesenteric lymphadenitis, which adopts the following technical scheme:
a Chinese medicinal composition for treating mesenteric lymphadenitis comprises, by weight, 5-30 parts of fructus evodiae, 10-20 parts of rhizoma galangae, 10-30 parts of radix paeoniae alba, 10-20 parts of radix glycyrrhizae preparata, 10-30 parts of trogopterus dung, 10-30 parts of pollen typhae, 10-30 parts of selfheal and 5-20 parts of thunberg fritillary bulb.
Further comprises evodia rutaecarpa 5, galangal 10, white peony root 10, honey-fried licorice root 10, trogopterus dung 10, cattail pollen 10, selfheal 10 and thunberg fritillary bulb 5.
Further comprises 15 of fructus evodiae, 15 of galangal, 15 of white paeony root, 15 of honey-fried licorice root, 20 of trogopterus dung, 20 of cattail pollen, 20 of selfheal and 15 of thunberg fritillary bulb.
Further comprises 30 of fructus evodiae, 20 of galangal, 30 of white paeony root, 20 of honey-fried licorice root, 30 of trogopterus dung, 30 of cattail pollen, 30 of selfheal and 20 of thunberg fritillary bulb.
In a second aspect, the invention discloses an acupoint application for treating mesenteric lymphadenitis, which adopts the following technical scheme:
an acupoint patch for the treatment of mesenteric lymphadenitis, comprising the Chinese medicinal composition for the treatment of mesenteric lymphadenitis according to any one of claims 1-4.
Further, the acupoint application agent is applied to the Shenque acupoint.
In a third aspect, the invention discloses a preparation method of an acupoint application for treating mesenteric lymphadenitis, which adopts the following technical scheme:
a method for preparing an acupoint plaster for treating mesenteric lymphadenitis, which comprises the steps of washing the Chinese medicinal composition for treating mesenteric lymphadenitis according to any one of claims 1 to 4, extracting with water, drying, pulverizing, adding excipient, honey and the like, and preparing into plaster.
Further, in the water extraction step, the ratio of the traditional Chinese medicine composition to water is 1: 8.
by adopting the technical scheme:
evodia fruit: pungent, bitter and hot in flavor; entering liver, spleen, stomach and kidney meridians; the functions of dispelling cold and relieving pain, lowering adverse qi and arresting vomiting, and supporting yang and arresting diarrhea; can be used for treating syncope headache, cold hernia abdominal pain, cold dampness loempe, menstrual abdominal pain, emesis, acid regurgitation, morning diarrhea, etc. The book Jing: it has the actions of warming middle-jiao and descending qi, alleviating pain, relieving cough, expelling cold and heat, removing dampness and blood obstruction, expelling wind-evil and opening striae. The bibliography: cold phlegm, abdominal cramps, cold and excess, nausea, epigastric pain, adverse qi, and five internal organs. Treatise on herb Property: heart and abdomen diseases, cold accumulation, qi stagnation in the heart, chronic infectious disease heartache; it is indicated for cholera with spasm of tendons and cold in stomach manifested as vomiting and diarrhea with abdominal pain unable to surpass tolerance.
Galangal rhizome: pungent taste and hot property; spleen and stomach meridians entered; has the functions of warming stomach, arresting vomiting, dispelling cold and relieving pain; can be used for treating abdominal psychroalgia, stomach cold emesis, belch and acid regurgitation, etc. The book Ben Cao Hui Yan (treatise on materia Medica): the essential herbs for dispelling cold-dampness and warming spleen and stomach are also indicated. Compendium of materia Medica: strengthening the spleen and stomach, wide dysphagia, attack of coldness and malaria. The herbal Zhenzhen: galangal, together with Jiang and Fu Zi, can enter stomach to dissipate cold; like Xiang Fu, it can remove cold and alleviate depression.
White peony root: bitter and sour taste, slightly cold nature; entering liver and spleen meridians; the functions of nourishing blood, regulating menstruation, astringing yin, arresting sweating, softening liver, relieving pain and calming liver yang; can be used for treating blood deficiency, sallow complexion, menoxenia, spontaneous perspiration, night sweat, hypochondriac pain, abdominal pain, limb spasm pain, headache, vertigo, etc. The book of academic records: it can be used for treating abdominal pain due to pathogenic factors, removing blood stagnation, resolving hard mass, treating hernia due to cold and heat, relieving pain, promoting urination, and invigorating qi. The bibliography: smoothing blood vessels, relieving epigastric distention, dispersing blood stasis, expelling blood stasis, removing water and qi, benefiting bladder, large intestine and small intestine, and eliminating carbuncle and swelling, and treating cold and heat, abdominal pain and lumbago.
Honey-fried licorice root: warm in nature and sweet in taste; the heart meridian, the lung meridian, the stomach meridian and the spleen meridian; has the functions of invigorating spleen and stomach, benefiting qi and recovering pulse, and relieving spasm and pain; can be used for treating weakness of spleen and stomach, asthenia, palpitation, intermittent pulse, spasm and pain.
Trogopterus dung: bitter and sweet in nature and warm in taste; enter liver and spleen meridians. Unprocessed has the effect of promoting blood circulation to relieve pain, and is used for treating pain caused by blood and qi of heart and abdomen, amenorrhea and postpartum blood stasis; stir-baked for stopping bleeding. It is indicated for metrorrhagia, menorrhagia and metrostaxis. The book of Kaibao Ben Cao: mainly treats cold heart and abdomen, infant malnutrition, keeps away epidemic disease, treats intestinal wind, promotes qi circulation and prevents obstruction of the female moon. The "the herbal atlas" (the book's Manual of medical science): it is used for cold accumulation and children. Supplement to the Yanyi of Ben Cao (supplement to the Yan Yi of materia Medica): can promote blood circulation and stop bleeding. It is indicated for cold in the heart and abdomen, pain in the heart of women and stabbing pain due to blood and qi. Compendium of materia Medica: can be used for relieving menorrhagia, leucorrhea with reddish discharge, antenatal and puerperal pain due to blood and qi stagnation; all the heart, abdomen and hypochondriac area are kept for men and women. Lower abdominal pain, colic, bloody dysentery, intestinal wind, abdominal pain; blood arthralgia, stabbing pain, liver malaria with chills and fever, regurgitation, diabetes.
Cattail pollen: sweet and mild in nature and taste; entering liver and pericardium; stopping bleeding, removing blood stasis, and treating stranguria; can be used for treating hematemesis, epistaxis, hemoptysis, metrorrhagia, traumatic hemorrhage, amenorrhea, chest pain, abdominal pain, traumatic injury, swelling and pain, stranguria with blood, and pain. The book Jing: cold and heat in the heart, abdomen and bladder, promote urination, stop bleeding and eliminate blood stasis. Taking for a long time can lighten the body, benefit strength and prolong the life of the immortal spirit. Compendium of materia Medica: cool blood and activate blood, relieve pain of heart and abdomen.
Selfheal: pungent, bitter and cold in nature; it enters liver and gallbladder meridians; clearing liver-fire, improving eyesight, resolving hard mass and relieving swelling; can be used for treating conjunctival congestion, swelling and pain, eye bead nyctalgia, headache, giddiness, scrofula, goiter, mammary abscess, mammary nodules, and breast pain.
Thunberg fritillary bulb: the nature and flavor of the meridian entered into the cold nature and bitter taste. Entering lung meridian and heart meridian; clearing heat, resolving hard mass, eliminating phlegm and relieving cough; belongs to heat-phlegm-clearing herbs classified under phlegm-resolving, cough-relieving and asthma-relieving herbs.
Compared with the prior art, the invention has the beneficial effects that:
the external application plaster for treating mesenteric lymphadenitis prepared by the raw material proportion and the method of the invention has the following components: the Chinese medicinal composition can activate the self-healing force of a human body, promote the circulation of qi and blood, diminish inflammation, dissipate stagnation, relieve spasm, relieve pain and the like, directly reaches a focus by pasting on the Shenque point and utilizing the point penetration, has good curative effect on the mesenteric lymphadenitis, has quick response and simple use method, and can overcome the defects that oral medicaments are slowly absorbed and cannot directly reach the focus and the defect that western medicine targets are single.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions of the embodiments of the present application will be clearly and completely described below. It should be apparent that the described embodiments are only some of the embodiments of the present application, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the described embodiments of the application without any inventive step, are within the scope of protection of the application.
Unless defined otherwise, technical or scientific terms used herein shall have the ordinary meaning as understood by one of ordinary skill in the art to which this application belongs. The use of the terms "a" or "an" and the like in the description and in the claims of the present application do not denote a limitation of quantity, but rather denote the presence of at least one.
The invention discloses a traditional Chinese medicine composition for treating mesenteric lymphadenitis, which is prepared from the following raw materials in parts by weight: 5 to 30 portions of fructus evodiae, 10 to 20 portions of galangal, 10 to 30 portions of white peony root, 10 to 20 portions of honey-fried licorice root, 10 to 30 portions of trogopterus dung, 10 to 30 portions of cattail pollen, 10 to 30 portions of selfheal and 5 to 20 portions of thunberg fritillary bulb.
An acupoint application for treating mesenteric lymphadenitis comprises the traditional Chinese medicine composition for treating mesenteric lymphadenitis.
A preparation method of an acupoint plaster for treating mesenteric lymphadenitis comprises washing the Chinese medicinal composition with water, extracting with water, oven drying, pulverizing, adding excipient, Mel, etc., and making into plaster.
The acupoint application agent prepared by the application acts on the Shenque acupoint.
Example 1:
a Chinese medicinal composition for treating mesenteric lymphadenitis comprises fructus evodiae 5, rhizoma Alpiniae Officinarum 10, radix Paeoniae alba 10, radix Glycyrrhizae Preparata 10, Oletum Trogopterori 10, pollen Typhae 10, Prunellae Spica 10, and Bulbus Fritillariae Thunbergii 5.
An acupoint application for treating mesenteric lymphadenitis comprises the traditional Chinese medicine composition for treating mesenteric lymphadenitis.
A preparation method of an acupoint application agent for treating mesenteric lymphadenitis comprises cleaning the above medicinal materials, decocting with 8 times of water for 30 minutes, taking decoction, adding 6 times of water into residues, decocting for 15 minutes, mixing decoctions, rotating a film at 60 ℃, vacuum-concentrating, vacuum-drying at 60 ℃, pulverizing, sieving with a No. 9 sieve, adding 0.5 times of liquid paraffin by weight to adjust the hardness of the thick paste, promoting dissolution of liposoluble components, increasing percutaneous permeation of effective components, adding 1 time of honey as an adhesive by weight, filling 3 g of the paste into a medical hollow acupoint application, covering a medical plastic film on the surface, packaging in a medical aluminum foil bag, and packaging for later use.
The using method comprises the following steps:
the external patch is applied to the Shenque acupoint for 12 hours each time; one patch is taken every day, and 10 days is 1 course of treatment.
Use contraindications: it is contraindicated for skin allergy or skin injury.
And (3) evaluating the curative effect:
and (3) healing: the inflammation of mesenteric lymph nodes disappears, the mesenteric lymph nodes are not swollen after B-ultrasonic repeated examination, and the mesenteric lymph nodes do not relapse within 1 year of follow-up visit;
remarkably: the symptoms of mesenteric lymphadenitis are obviously relieved;
the method has the following advantages: the symptoms of mesenteric lymphadenitis are relieved;
and (4) invalidation: the change before and after treatment is not large.
And (3) analyzing the curative effect:
97 cases of children with mesenteric lymphadenitis are treated; 55 men and 42 women. The course of the disease is as follows: 30 cases in 2-5 months, and 67 cases in 6 months to 1 year.
Age group: 37 cases under 6 years old and 60 cases under 7-15 years old.
The treatment time is as follows: the shortest patient has 1 course, the longest patient has 6 courses, and the average number of courses is 4.
The treatment effect is as follows: 77 cases are cured clinically, 13 cases with obvious curative effect and 7 cases with unobvious curative effect.
The number of effective treatments was 89, and the number of ineffective treatments was 8.
The specific implementation principle of the invention is as follows:
the external application preparation for treating mesenteric lymphadenitis prepared by the raw material proportion and the method has the effects of activating the self-healing force of a human body, smoothing qi and blood, diminishing inflammation, resolving masses, relieving spasm, relieving pain and the like, directly reaches a focus by applying the external application preparation to a Shenque point and utilizing the penetration of acupuncture points, has good curative effect on mesenteric lymphadenitis, is quick in effect taking and simple in use method, and can overcome the defects that oral medicines are slowly absorbed and cannot directly reach the focus and the defect that western medicine targets are single.
Example 2:
the difference between the embodiment and the embodiment 1 is that the traditional Chinese medicine composition for treating mesenteric lymphadenitis is prepared from the following raw materials in parts by weight: comprises 15 portions of evodia rutaecarpa, 15 portions of galangal, 15 portions of white peony root, 15 portions of honey-fried licorice root, 20 portions of trogopterus dung, 20 portions of cattail pollen, 20 portions of selfheal and 15 portions of thunberg fritillary bulb.
Example 3:
the difference between the embodiment and the embodiment 1 is that the traditional Chinese medicine composition for treating mesenteric lymphadenitis is prepared from the following raw materials in parts by weight: comprises evodia rutaecarpa 17, galangal 15, white peony root 17, honey-fried licorice root 14, trogopterus dung 15, cattail pollen 15, selfheal 15 and thunberg fritillary bulb 15.
Example 4:
the difference between the embodiment and the embodiment 1 is that the traditional Chinese medicine composition for treating mesenteric lymphadenitis is prepared from the following raw materials in parts by weight: comprises 30 of fructus evodiae, 20 of galangal, 30 of white paeony root, 20 of honey-fried licorice root, 30 of trogopterus dung, 30 of cattail pollen, 30 of selfheal and 20 of thunberg fritillary bulb.
Comparative example 1:
a traditional Chinese medicine composition for treating mesenteric lymphadenitis is prepared from the following raw materials in parts by weight: galangal 10, white paeony root 10, honey-fried licorice root 10, trogopterus dung 10, cattail pollen 10, selfheal 10 and thunberg fritillary bulb 5, and an acupoint application for treating mesenteric lymphadenitis, which comprises the traditional Chinese medicine composition for treating mesenteric lymphadenitis, the specific preparation method is the same as that of example 1, and compared with example 1, the traditional Chinese medicine composition is not added with evodia rutaecarpa, so that the treatment effect is obviously reduced: has the advantages of prolonged action time, slow symptom improvement, and reduced cure rate.
Comparative example 2:
a traditional Chinese medicine composition for treating mesenteric lymphadenitis is prepared from the following raw materials in parts by weight: the specific preparation method is the same as that of example 1, compared with example 1, the amount of added fructus evodiae is small, and the treatment effect is obviously reduced compared with example 1: has the advantages of prolonged action time, slow symptom improvement, and reduced cure rate.
Comparative example 3:
a traditional Chinese medicine composition for treating mesenteric lymphadenitis is prepared from the following raw materials in parts by weight: the specific preparation method is the same as that of example 1, compared with example 1, the amount of added evodia rutaecarpa is more, and the treatment effect is obviously improved compared with example 1: has short acting time, quick symptom improvement and high cure rate.
Through comparative examples 1-3 and example 1, it can be shown that the formula has the following advantages that the evodia rutaecarpa is absent or the dosage is reduced in the preparation process, and the treatment effect is obviously reduced: has the advantages of prolonged action time, slow symptom improvement, and reduced cure rate. The medicine is indicated to play a main role in treating mesenteric lymphadenitis due to the inexistence or lack of position in the formula.
Comparative example 4:
a traditional Chinese medicine composition for treating mesenteric lymphadenitis is prepared from the following raw materials in parts by weight: evodia rutaecarpa 5, white paeony root 10, honey-fried licorice root 10, trogopterus dung 10, cattail pollen 10, selfheal 10 and thunberg fritillary bulb 5, and the acupoint application for treating mesenteric lymphadenitis comprises the traditional Chinese medicine composition for treating mesenteric lymphadenitis, and the specific preparation method is the same as that in example 1, compared with example 1, the treatment effect of the unadditized galangal is obviously improved compared with that in example 1: has short acting time, quick symptom improvement and high cure rate.
Comparative example 5:
a traditional Chinese medicine composition for treating mesenteric lymphadenitis is prepared from the following raw materials in parts by weight: evodia rutaecarpa 5, galangal 10, honey-fried licorice root 10, trogopterus dung 10, cattail pollen 10, selfheal 10 and thunberg fritillary bulb 5, and a acupoint application for treating mesenteric lymphadenitis, which comprises the traditional Chinese medicine composition for treating mesenteric lymphadenitis, the specific preparation method is the same as that of example 1, compared with example 1, the treatment effect is obviously improved compared with that of example 1 due to the fact that no white paeony root is added: has short acting time, quick symptom improvement and high cure rate.
Comparative example 6:
a Chinese medicinal composition for treating mesenteric lymphadenitis, the plaster comprises fructus evodiae 5, rhizoma galangae 10, radix paeoniae alba 10, trogopterus dung 10, pollen typhae 10, selfheal 10 and thunberg fritillary bulb 5 according to the weight portion, an acupoint plaster for treating mesenteric lymphadenitis comprises the Chinese medicinal composition for treating mesenteric lymphadenitis, the specific preparation method is the same as that of example 1, compared with example 1, the treatment effect of honey-fried licorice root which is not added is obviously improved compared with that of example 1: has short acting time, quick symptom improvement and high cure rate.
Comparative example 7:
a Chinese medicinal composition for treating mesenteric lymphadenitis, the plaster comprises fructus evodiae 5, rhizoma galangae 10, radix paeoniae alba 10, radix glycyrrhizae preparata 10, pollen typhae 10, selfheal 10 and thunberg fritillary bulb 5 according to the weight portion, an acupoint plaster for treating mesenteric lymphadenitis comprises the Chinese medicinal composition for treating mesenteric lymphadenitis, the specific preparation method is the same as that of example 1, compared with example 1, the treatment effect of the traditional Chinese medicinal composition is obviously improved without adding trogopterus dung compared with that of example 1: has short acting time, quick symptom improvement and high cure rate.
Comparative example 8:
a Chinese medicinal composition for treating mesenteric lymphadenitis, the plaster comprises fructus evodiae 5, rhizoma galangae 10, radix paeoniae alba 10, radix glycyrrhizae preparata 10, trogopterus dung 10, selfheal 10 and thunberg fritillary bulb 5 according to the weight parts, an acupoint plaster for treating mesenteric lymphadenitis comprises the Chinese medicinal composition for treating mesenteric lymphadenitis, the specific preparation method is the same as that of example 1, compared with example 1, the treatment effect of the Chinese medicinal composition is obviously improved when pollen typhae is not added: has short acting time, quick symptom improvement and high cure rate.
Comparative example 9:
a Chinese medicinal composition for treating mesenteric lymphadenitis, the plaster comprises fructus evodiae 5, rhizoma galangae 10, radix paeoniae alba 10, radix glycyrrhizae preparata 10, trogopterus dung 10, pollen typhae 10 and thunberg fritillary bulb 5 according to the weight portion, an acupoint plaster for treating mesenteric lymphadenitis comprises the Chinese medicinal composition for treating mesenteric lymphadenitis, the specific preparation method is the same as that of example 1, compared with example 1, the treatment effect of the Chinese medicinal composition is obviously improved by not adding selfheal compared with that of example 1: has short acting time, quick symptom improvement and high cure rate.
Comparative example 10:
a Chinese medicinal composition for treating mesenteric lymphadenitis, the plaster comprises fructus evodiae 5, rhizoma galangae 10, radix paeoniae alba 10, radix glycyrrhizae preparata 10, trogopterus dung 10, pollen typhae 10 and selfheal 10 by weight, an acupoint plaster for treating mesenteric lymphadenitis comprises the Chinese medicinal composition for treating mesenteric lymphadenitis, the specific preparation method is the same as that of example 1, compared with example 1, the treatment effect of the non-added Thunberg fritillary bulb is obviously improved compared with that of example 1: has short acting time, quick symptom improvement and high cure rate.
From comparative examples 4 to 10 and example 1, it can be seen that the formulation has a significant decrease in therapeutic effect in the absence or dose of the drug during formulation: has the advantages of prolonged action time, slow symptom improvement, and reduced cure rate.
Typical cases
In case one, a certain Liu is in age 9, the abdominal pain, the abdominal distension and the constipation are intercropped for 7 months, local hospitals are diagnosed as mesenteric lymphadenitis through B-ultrasonic examination and the like, and the diagnosis is performed by the unobvious treatment effect of anti-inflammatory and analgesic western medicines; the western medicine is not used, and the acupoint plaster is applied to the Shenque acupoint for 12 hours, one plaster per day. The abdominal pain is relieved after the plaster is applied for 3 days; after being pasted for 1 course of treatment, the abdominal pain does not occur, and abdominal distension and constipation are relieved; continuously applying for 1 course of treatment, and relieving symptoms; and then the application is consolidated for 2 courses. After 4 treatment courses, the B-ultrasonic examination shows that the mesenteric lymph nodes are not swollen. After 1 year, the follow-up visit, abdominal pain and abdominal distension, etc. are not released.
In case II, old patient, female patient, age 12, abdominal pain and abdominal distension intercropping for 5 months with anorexia and loose stool, local hospital has been diagnosed as mesenteric lymphadenitis through B-ultrasonic examination, and the diagnosis is made by the unobvious treatment effect of anti-inflammatory and analgesic western medicines; the western medicines are stopped, and the acupoint plaster is applied to the Shenque acupoint for 12 hours, namely one plaster every day. The abdominal pain is relieved after 2 days of application, and disappears after 5 days of application; after being applied for 1 course of treatment, the excrement is normal, and the diet is increased; and then the paste is consolidated and applied for 3 courses. No enlargement of mesenteric lymph node is observed after 4 courses of treatment by B ultrasonic examination. After 1 year, the follow-up visit, abdominal pain and abdominal distension, etc. are not released.
The embodiments of the present invention are the preferred embodiments of the present invention, and the scope of the present invention is not limited by the embodiments, so: all equivalent changes made according to the structure, shape and principle of the invention are covered by the protection scope of the invention.

Claims (8)

1. A traditional Chinese medicine composition for treating mesenteric lymphadenitis is characterized in that the plaster comprises, by weight, 5-30 parts of fructus evodiae, 10-20 parts of galangal, 10-30 parts of white paeony root, 10-20 parts of honey-fried licorice root, 10-30 parts of trogopterus dung, 10-30 parts of pollen typhae, 10-30 parts of selfheal and 5-20 parts of thunberg fritillary bulb.
2. The traditional Chinese medicine composition for treating mesenteric lymphadenitis according to claim 1, which comprises fructus evodiae 5, rhizoma galangae 10, radix paeoniae alba 10, radix glycyrrhizae preparata 10, trogopterus dung 10, pollen typhae 10, selfheal 10 and thunberg fritillary bulb 5.
3. The traditional Chinese medicine composition for treating mesenteric lymphadenitis according to claim 1, which comprises fructus evodiae 15, rhizoma galangae 15, radix paeoniae alba 15, radix glycyrrhizae preparata 15, trogopterus dung 20, pollen typhae 20, selfheal 20 and thunberg fritillary bulb 15.
4. The traditional Chinese medicine composition for treating mesenteric lymphadenitis according to claim 1, which comprises fructus evodiae 30, rhizoma galangae 20, radix paeoniae alba 30, radix glycyrrhizae preparata 20, trogopterus dung 30, pollen typhae 30, selfheal 30 and thunberg fritillary bulb 20.
5. An acupoint application for treating mesenteric lymphadenitis, which is characterized by comprising the traditional Chinese medicine composition for treating mesenteric lymphadenitis according to any one of claims 1 to 4.
6. The acupoint application for treating mesenteric lymphadenitis according to claim 5, wherein the acupoint application is applied on the Shenque acupoint.
7. A preparation method of an acupoint plaster for treating mesenteric lymphadenitis is characterized by comprising the traditional Chinese medicine composition for treating mesenteric lymphadenitis according to any one of claims 1 to 4, and the traditional Chinese medicine composition is prepared into the plaster by washing, extracting with water, drying, crushing, adding excipients, honey and the like.
8. The method for preparing an acupoint application for treating mesenteric lymphadenitis according to claim 7, wherein in the water extraction step, the mixing ratio of the traditional Chinese medicine composition and water is 1: 8.
CN202111260330.0A 2021-10-28 2021-10-28 Traditional Chinese medicine composition and application for treating mesenteric lymphadenitis and preparation method thereof Pending CN114159534A (en)

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Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
周幸来: "《董氏儿科倪菊秀论治小儿脾胃病》", 上海科学技术出版社 *

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