CN111514262B - Self-heating acupoint application traditional Chinese medicine composition and preparation method thereof - Google Patents

Self-heating acupoint application traditional Chinese medicine composition and preparation method thereof Download PDF

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CN111514262B
CN111514262B CN202010363452.1A CN202010363452A CN111514262B CN 111514262 B CN111514262 B CN 111514262B CN 202010363452 A CN202010363452 A CN 202010363452A CN 111514262 B CN111514262 B CN 111514262B
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CN111514262A (en
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李冰石
陆为民
季春艳
谷雨
颜权云
郭婷
施荣伟
王春霞
方芳
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Jiangsu Provincial Hospital of Chinese Medicine
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Abstract

The invention discloses a self-heating acupoint application traditional Chinese medicine composition and a preparation method thereof, and the self-heating acupoint application traditional Chinese medicine composition comprises 10-20 parts of cinnamomum wilsonii twig, 10-20 parts of radix angelicae, 6-12 parts of clove, 6-12 parts of cinnamon, 6-12 parts of radix paeoniae alba, 6-12 parts of honey-fried licorice root, 4-10 parts of prepared aconite root, 4-10 parts of prepared rhizoma cyperi, 4-10 parts of galangal, 4-10 parts of fructus evodiae, 4-10 parts of katsumade galangal seed, 2-8 parts of dried orange peel, 2-8 parts of common fennel, 2-8 parts of paniculate swallowwort root, 2-8 parts of ligusticum wallichii, 2-5 parts of combined spicebush root, 2-5 parts of folium artemisiae argyi and 2-5 parts of perilla leaf. The traditional Chinese medicine smell applied to the invention enters skin striae and Yu points, then enters Sun veins and collaterals, enters channels, runs along with qi and blood, reaches viscera internally, spreads on the whole body, can play a role in regulating the human body by the meridian and the Yu points, and can achieve the effects of regulating qi and blood yin and yang of viscera, strengthening body resistance to eliminate pathogenic factors, nourishing vitality and tonifying qi, warming spleen and tonifying kidney, warming kidney and tonifying yang, activating blood and dissolving stasis, warming channels and relieving pain, treating inflammation, relieving pain and the like.

Description

Self-heating acupoint application traditional Chinese medicine composition and preparation method thereof
Technical Field
The invention belongs to the field of traditional Chinese medicines, and particularly relates to a self-heating acupoint application traditional Chinese medicine composition with the effects of warming middle-jiao, dispelling cold, promoting blood circulation and dredging collaterals and a preparation method thereof.
Background
The acupoint application therapy is to stimulate skin acupoints with traditional Chinese medicines, and exert the overall regulation effect of the meridian system to regulate yin and yang, strengthen body resistance to eliminate pathogenic factors, and dredge meridians, thereby achieving the purpose of treating diseases. The traditional Chinese medicine acupoint application therapy has the treatment effects of removing pathogenic factors, eliminating causes, correcting preponderance and decline of yin and yang and recovering the function coordination of viscera according to the four flavors, ascending, descending, sinking and floating of the medicines and meridian tropism according to the attributes. The medicine is taken according to syndrome differentiation, absorbed at corresponding acupuncture points of a patient body, enters body fluid, and is distributed to internal organs of the five viscera and nine orifices of four limbs through qi and blood transmission of channels, so as to exert pharmacological effects. The smell of the medicine enters the skin striae and acupoints, then the Sun vessels and collaterals, and further enters the meridians, and the qi and blood flow, and reaches the zang-fu organs and spreads throughout the body, thereby playing the therapeutic role of the medicine.
In ancient China, stone needles exist, and can be used for treating diseases by using stones, and the stone needles are originated in the age of stone apparatus and are originally appeared in Huangdi's internal classic, and can be understood as the stones for treating the diseases at present. The stone needle can emit a plurality of far infrared rays and ultrasonic pulses which are beneficial to the human body, promote microcirculation, condition metabolism and generate: (1) massage function; (2) a heating effect; (3) nervous system effects; (4) promoting blood circulation, etc. In order to better meet the living health requirements of the full-bodied modern people, the stone needle needs to be simply applied, and a product which is combined with the existing pasting material, namely the spontaneous heating acupuncture point paste, is developed to improve the symptoms of a plurality of cold syndrome patients applying the acupuncture point paste and achieve better treatment effect.
The existing application method comprises the following steps: the prepared powder, paste, mud or extract is placed in the center of the adhesive surface of the adhesive plaster in advance, and then the plaster is pasted by aiming at the acupoints. For patients allergic to adhesive plaster, low-allergy adhesive tape or bandage can be used for fixing and applying medicine. The adhesive tape that uses at present pastes complex operation, even adopt finished product self-adhesion to apply ointment or plaster, very easily drops when the patient carries out daily activity or sweats, influences treatment, and the infiltration of drug effect is catalyzed only by the temperature of body moreover, and clinical frequent meeting dosage use easily lets the medicine of skin foaming in order to increase the effect, has increased the probability that skin takes place to be allergic, bubble, ulcerate.
Disclosure of Invention
The invention aims to solve the technical problem of the prior art and provides a self-heating acupoint-applied traditional Chinese medicine composition, which is automatically heated through an acupoint patch, so that active ingredients of the traditional Chinese medicine composition enter meridians, run along with qi and blood, reach viscera internally and spread throughout the body, and achieve the effects of regulating qi and blood yin and yang of viscera, strengthening body resistance to eliminate pathogenic factors, reinforcing vital essence, tonifying qi, warming spleen and tonifying kidney, warming kidney and tonifying yang, promoting blood circulation to remove blood stasis, warming meridians to relieve pain, treating inflammation, relieving pain and the like.
In order to achieve the aim, the invention discloses a self-heating acupoint application traditional Chinese medicine composition which is prepared from the following raw material medicines in parts by weight:
10-20 parts of Sichuan cassia twig,
10-20 parts of radix angelicae dahuricae,
6-12 parts of clove, namely,
6-12 parts of cinnamon, namely,
6-12 parts of white paeony root,
6-12 parts of honey-fried licorice root,
4 to 10 parts of auxiliary pieces are prepared,
4-10 parts of prepared rhizoma cyperi,
4 to 10 parts of galangal, by weight,
4-10 parts of fructus evodiae,
4-10 parts of katsumade galangal seed,
2-8 parts of dried orange peel,
2-8 parts of fennel fruit,
2-8 parts of paniculate swallowwort root,
2-8 parts of ligusticum wallichii, including,
2-5 parts of radix linderae,
2-5 parts of folium artemisiae argyi,
2-5 parts of perilla leaves.
Preferably, the self-heating acupoint application traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight:
15 parts of Sichuan cassia twig, prepared rehmannia root,
15 parts of dahurian angelica root, radix angelicae dahuricae,
10 parts of clove, namely clove,
10 parts of cinnamon, namely 10 parts of cinnamon,
10 parts of white paeony root, namely white paeony root,
10 parts of honey-fried licorice root, radix glycyrrhizae preparata,
8 parts of accessory pieces are prepared,
8 parts of prepared nutgrass galingale rhizome,
8 parts of galangal, namely 8 parts of galangal,
8 parts of fructus evodiae, namely fructus evodiae,
8 parts of katsumade galangal seed, namely,
5 parts of dried orange peel, namely dried orange peel,
5 parts of fennel fruit, namely fennel,
5 parts of paniculate swallowwort root,
5 parts of ligusticum wallichii, namely,
3 parts of radix linderae, namely,
3 parts of folium artemisiae argyi, namely 3 parts of folium artemisiae argyi,
and 3 parts of perilla leaves.
The traditional Chinese medicine compatibility principle of the traditional Chinese medicine composition is as follows:
in the formula, cassia twig and dahurian angelica root, pungent and hot in property, warm spleen and dispel cold, and invigorate yang and dispel cold are monarch drugs. The waist is house of kidney, the knee is house of tendon and tendon, and wind-cold-dampness obstructs the joint, so the waist and knee joint are painful and difficult to bend and stretch; qi and blood are obstructed, and tendons and vessels cannot be nourished, so that numbness is caused; cold-dampness is the pathogenic yin, and when it gets warm, it will decline, so aversion to cold and preference for warm; the yang deficiency is accompanied with qi weakness, and the qi hyperactivity can also assist yang, so the sweet and warm clove, cinnamon, white peony root and honey-fried licorice root are used as the ministerial drugs to replenish qi, invigorate the spleen, tonify deficiency and assist yang. The monarch and minister drugs are matched to warm the middle-jiao, strengthen the spleen and dispel cold. For treatment, it should dispel wind-damp-cold, stop arthralgia, tonify liver and kidney, tonify qi and blood, eliminate pathogens and strengthen healthy qi. Prepared aconite slice, prepared rhizoma cyperi, galangal, evodia rutaecarpa, katsumadai seed, dried orange peel, fennel and paniculate swallowwort root for nourishing liver and kidney, strengthening bones and muscles, strengthening waist and knees and expelling wind-damp; ginseng, Poria, and radix Glycyrrhizae, all of which are adjuvant drugs, have the effects of invigorating qi, strengthening spleen, nourishing blood, and promoting blood circulation. Chuan Xiong, Wu Yao, ai Ye and Su Ye are all guiding herbs for assisting in warming the middle energizer and dredging collaterals. The compatibility of the prescription is characterized in that: mainly warms middle energizer to dispel cold, promotes blood circulation to remove meridian obstruction, is supplemented with liver and kidney tonifying and qi and blood nourishing products, eliminates pathogenic factors without damaging healthy qi, and strengthens healthy qi without hindering pathogenic factors. The medicines are combined to eliminate wind-cold-dampness, so that qi and blood are sufficient, liver and kidney are strong, and all the symptoms are self-healed.
Ramulus Cinnamomi
[ drug properties ]: pungent, sweet and warm. Enter heart, lung and bladder meridians.
[ efficacy ]: relieving exterior syndrome by inducing sweat, warming and dredging channels and collaterals, activating yang, and regulating qi-flowing.
[ application ]: can be used for treating wind-cold exterior syndrome, cold-dampness arthralgia, amenorrhea abdominal pain, dysmenorrhea, phlegm retention, cough and asthma due to retention of water-dampness, and dysuria.
[ pharmacological ] of: tranquilizing, analgesic, antipyretic, anticonvulsive, antibacterial, antiviral, diuretic, antiinflammatory, and immunity improving effects.
Root of Dahurian Angelica
[ drug properties ]: pungent and warm. It enters lung, stomach and large intestine meridians.
[ efficacy ]: relieving exterior syndrome, dispelling cold, dispelling pathogenic wind, relieving pain, dredging nasal orifice, eliminating dampness, stopping leukorrhagia, relieving swelling, and expelling pus.
[ application ]: wind-cold type common cold, headache, wind-damp arthralgia, nasal obstruction, nasal discharge and leukorrhagia.
[ pharmacological ] of: antipyretic, antiinflammatory, analgesic, spasmolytic, and anticancer effects.
Lilac
[ drug properties ]: pungent and warm. It enters spleen, stomach, lung and kidney meridians.
[ efficacy ]: to warm the middle-jiao and descend the adverse flow of qi, tonify the kidney and strengthen yang.
[ application ]: deficiency-cold of spleen and stomach, hiccup vomiting, poor appetite, vomiting and diarrhea, cold pain in heart and abdomen, impotence due to kidney deficiency, cold womb, etc.
[ pharmacological ] of: has effects in promoting gastric secretion, improving digestion, relieving nausea and emesis, relieving abdominal flatulence, relieving pain, relieving inflammation, resisting diarrhea, promoting gallbladder function, and resisting anoxia.
Cortex Cinnamomi
[ drug properties ]: pungent, sweet and big heat. It enters kidney, spleen, heart and liver meridians.
[ efficacy ]: tonify fire and strengthen yang, dispel cold to alleviate pain, warm meridians and activate collaterals, induce fire to return to original.
[ application ]: impotence, cold womb, cold pain in the waist and knees, cold pain in the heart and abdomen, vomiting and diarrhea due to deficiency-cold, cold-dampness arthralgia, vertigo, conjunctival congestion, etc.
[ pharmacological ] of: has effects in improving blood flow of coronary artery and brain, tranquilizing mind, relieving pain, relieving fever, relieving convulsion, and inhibiting formation of experimental ulcer.
White peony root
[ drug properties ]: bitter and sour taste, slightly cold. It enters liver meridian.
[ efficacy ]: has effects of suppressing liver yang, softening liver, relieving pain, astringing yin, and nourishing blood.
[ application ]: it is clinically used for headache, vertigo, tinnitus, dysphoria and irritability caused by liver yin deficiency and liver yang hyperactivity; it is also used for abdominal or limb spasm pain and chest and hypochondrium pain caused by liver qi disharmony; it is also indicated for blood deficiency syndrome, yin deficiency with blood heat, blood loss, night sweat, exterior deficiency with spontaneous perspiration, etc.
[ pharmacological ] of: has certain blood pressure lowering effect, and certain inhibition effect on typhoid bacillus and dysentery bacillus.
Prepared licorice root
[ drug properties ]: enter heart, lung, spleen and stomach meridians.
[ efficacy ]: invigorating spleen, regulating stomach function, invigorating qi, recovering pulse, relieving cough and asthma, and relieving pain.
[ application ]: has effects in invigorating spleen, invigorating qi, eliminating phlegm, relieving cough, relieving pain, clearing away heat and toxic materials, and regulating various drugs. Can be used for treating palpitation and pulse due to deficiency of heart-qi, and fatigue, anorexia, and constipation due to spleen deficiency. Has expectorant and antitussive effects, and can be used for treating cough due to wind-cold evil, cough due to lung heat, cough due to phlegm-dampness, cough due to cold-phlegm, and asthma.
[ pharmacological ] of: corticoid-like effects; regulating the immune function of the organism; effects on the digestive system: antiulcer, spasmolytic, and hepatoprotective; cough relieving, medical education' net collection, arrangement and phlegm elimination; anti-inflammatory, anti-allergic reactions; antibacterial and antiviral effects; detoxification; anti-arrhythmic; reducing blood lipid and resisting atherosclerosis; has antitumor effect.
Auxiliary sheet
[ drug properties ]: pungent and sweet in flavor, strongly hot in property and toxic in property. It enters heart, kidney and spleen meridians.
[ efficacy ]: reviving yang to rescue adverse qi, tonifying fire to strengthen yang, and expelling pathogenic wind, cold and dampness.
[ application ]: can be used for treating symptoms such as yang exhaustion due to syncope and faint pulse, and is mainly used for treating spontaneous perspiration, syncope of limbs, weak pulse, or diseases due to profuse sweat, large vomiting, and large adverse rise of qi; can be used for treating kidney yang deficiency, aversion to cold, cold limbs, spleen yang deficiency, abdominal pain, and loose stool. (ii) a Can be used for treating arthralgia due to wind-cold-dampness, and arthralgia.
[ pharmacological ] of: the main pharmacological component of radix Aconiti lateralis is aconitine, and has effects of resisting cold, relieving pain, tranquilizing, local anesthesia, and resisting inflammation
Rhizoma Cyperi preparata
[ drug properties ]: pungent, slightly bitter and sweet in flavor and mild in nature.
[ efficacy ]: to soothe the liver, regulate qi, regulate menstruation and alleviate pain.
[ application ]: mainly used for treating liver qi stagnation, chest distress, hypochondriac pain, gastropathy and abdominal pain; and menoxenia and dysmenorrhea.
[ pharmacological ] of: inhibiting uterus, relieving spasm, promoting bile flow, relieving fever, tranquilizing mind, relieving pain, relieving inflammation, lowering blood pressure, and tonifying heart.
Galangal
[ drug properties ]: is toxic. Pungent and hot, entering spleen and stomach meridians.
[ efficacy ]: warm middle energizer to dispel cold, regulate qi-flowing to alleviate pain.
[ application ]: it can dispel cold from spleen and stomach, warm middle energizer and alleviate pain, so it is indicated for abdominal cold pain.
[ pharmacological ] of: antibacterial, delay thrombosis time, inhibit blood coagulation, and relieve pain.
Evodia rutaecarpa
[ drug properties ]: pungent, bitter and warm in flavor. It enters liver, spleen, stomach and kidney meridians.
[ efficacy ]: has the effects of dispelling cold, relieving pain, lowering adverse qi, arresting vomiting, supporting yang and stopping diarrhea.
[ application ]: can be used for treating syncope headache, hernia of cold, abdominal pain, tinea pedis due to cold dampness, abdominal pain during menstruation, abdominal pain, emesis, acid regurgitation, and diarrhea before dawn.
[ pharmacological ] of: mainly has analgesic effect, and can be used for dilating peripheral blood vessel. The evodiamine contained in fructus evodiae is bitter and has stomach invigorating effect. Has bidirectional effect on small intestine activity and spontaneous contraction activity.
Semen Alpiniae
[ drug properties ]: pungent-warm property leading to spleen and stomach meridians
[ efficacy ]: dry dampness and invigorate spleen, warm stomach and arrest vomiting.
[ application ]: it is indicated for cold-dampness retention, abdominal distention, cold pain, belching, vomiting and poor appetite.
[ pharmacological ] of: the activity of the pepsin can be obviously improved by the 10 percent leaching solution.
Dried orange peel
[ drug properties ]: pungent and bitter in flavor and warm in nature. It enters spleen and lung meridians.
[ efficacy ]: regulate qi-flowing for promoting appetite, dry dampness and resolve phlegm, treat spleen and stomach diseases. Belongs to qi-regulating herbs.
[ application ]: it is indicated for fullness in chest and epigastrium, anorexia, vomiting, cough and profuse sputum.
[ pharmacological ] of: adjusting the digestive system; exciting the heart; has certain prevention effect on arteriosclerosis caused by high fat diet; relieving asthma and eliminating phlegm; the renal blood vessels are contracted, and the urine volume is reduced; enhancing immune function; anti-inflammatory; can promote secretion of digestive juice such as saliva and gastric juice, and eliminate intestinal gas accumulation.
Fennel fruit
[ drug properties ]: warm in nature and pungent in flavor. It enters liver meridian, spleen meridian, stomach meridian and kidney meridian.
[ efficacy ]: dispel cold, alleviate pain, regulate qi and harmonize stomach. It belongs to interior-warming herbs.
[ application ]: treating abdominal pain due to hernia of cold type, testis tenesmus, dysmenorrhea, cold pain of lower abdomen, abdominal distention and pain, anorexia, vomiting and diarrhea, hydrocele of tunica vaginalis of testis, abdominal pain due to hernia of cold type, testis tenesmus, and abdominal pain due to channel cold type.
[ pharmacological ] of: promoting gastrointestinal peristalsis; anti-ulcer; benefiting gallbladder; relaxing tracheal smooth muscle; has sex hormone-like effect; central paralysis; bacteriostasis; and (3) resisting tumors. The intestinal canal is excited to strengthen contraction, and the concentration is increased to have spasmolysis; can inhibit stress gastric ulcer; has effects in inhibiting central nervous system, resisting coagulation, and resisting fibrinolysis.
XU CHANGQING
[ drug properties ]: pungent in flavor and warm in nature, it enters liver and stomach meridians.
[ efficacy ]: promoting urination, tranquilizing, relieving pain, removing blood stasis, removing toxic substance, activating collaterals, promoting blood circulation, reducing blood lipid and lowering blood pressure.
[ application ]: can be used for treating various pain syndromes such as rheumatalgia, heart and chest pain, lumbago, toothache, traumatic injury, blood stasis and swelling pain, and dermatogic diseases such as eczema, rubella, skin pruritus, and intractable tinea.
[ pharmacological ] of: has analgesic, tranquilizing, coronary artery blood flow increasing, myocardial metabolism improving, myocardial ischemia relieving, and antibacterial effects.
Rhizoma Ligustici Chuanxiong
[ drug properties ]: pungent and warm in flavor, it enters liver, gallbladder and heart meridians.
[ efficacy ]: promote blood circulation and move qi, dispel wind and alleviate pain.
[ application ]: it is mainly used for treating thoracic obstruction and heart pain due to heart vessel stagnation, hypochondriac distending pain due to liver depression and qi stagnation, chest and hypochondriac pricking pain due to liver blood stagnation, traumatic injury due to blood stasis, pyocutaneous disease and swelling pain, menoxenia, amenorrhea and dysmenorrhea, puerperal blood stasis and pain, lochiorrhea, various headaches and rheumatism pain.
[ pharmacological ] of: ligustrazine can expand coronary artery, improve myocardial blood oxygen supply, reduce myocardial oxygen consumption, reduce vascular resistance, significantly increase brain and limb blood flow, and improve microcirculation; inhibiting platelet aggregation and preventing thrombosis; and has obvious and lasting antihypertensive effect; can inhibit multiple bacilli; has antihistaminic and choleretic effects.
Combined spicebush root
[ drug properties ]: warm in nature and pungent in flavor. It enters lung meridian, spleen meridian, kidney meridian and bladder meridian.
[ efficacy ]: regulating qi, relieving depression, dispelling cold, and relieving pain. Belongs to qi-regulating herbs.
[ application ]: it can be used for treating abdominal distention and pain due to adverse qi, indigestion, regurgitation, vomiting, cold hernia, tinea pedis, and frequent micturition.
[ pharmacological ] of: has effects in improving gastrointestinal activity, relieving pain, stopping bleeding, protecting liver, inhibiting bacteria, relieving asthma, resisting histamine, stopping bleeding, resisting herpes simplex virus, and resisting cancer, and also has double effects of exciting and inhibiting isolated smooth muscle.
Folium Artemisiae Argyi
[ drug properties ]: bitter and pungent in flavor. Enter spleen, liver and kidney meridians.
[ efficacy ]: regulating menstruation, stopping bleeding, preventing miscarriage, relieving metrorrhagia, dispelling cold, removing dampness, eliminating phlegm, relieving cough, relieving pain, resisting bacteria, relieving itching, protecting liver, and promoting bile flow.
[ application ]: regulating qi and blood, dispelling cold and dampness; warm meridians, stop bleeding, prevent abortion. It is indicated for heart and abdominal psychroalgia, diarrhea, spasm of tendons, chronic dysentery, hematemesis, bleeding, menoxenia, metrorrhagia, leukorrhagia, threatened abortion, carbuncle, ulcer, scabies and tinea.
[ pharmacological ] of: has antibacterial, antiviral, antiasthmatic, antitussive, expectorant, antiallergic, hemostatic, anticoagulant, and immunity enhancing effects.
Su Ye
[ drug properties ]: pungent and warm. It enters lung and spleen meridians.
[ efficacy ]: relieve exterior syndrome, dispel cold, move qi and relieve epigastric distention.
[ application ]: resolving phlegm and relieving cough, and is good at treating wind-cold exterior syndrome with qi stagnation, chest distress, nausea and vomiting, regulating stomach function, relieving vomiting, regulating qi-flowing and preventing miscarriage
[ pharmacological ] of: has antipyretic, antiinflammatory, digestive juice secretion promoting, and intestinal peristalsis promoting effects.
Further, the invention provides a preparation method of the self-heating acupoint application traditional Chinese medicine composition, which comprises the following steps:
(1) drying the raw materials, and pulverizing together to obtain raw medicinal powder;
(2) cleaning rhizoma Zingiberis recens, pulverizing, squeezing with sterile gauze to obtain juice, and adding water to obtain rhizoma Zingiberis recens juice solution;
(3) mixing the medicinal powder of the raw material in the step (1) with the ginger juice solution in the step (2), and finally blending the mixture into a dry thick paste by using medical hot melt adhesive.
Specifically, in the step (1), the crushed raw material medicine is sieved by a sieve of 90-140 meshes to obtain raw material medicine powder.
In the step (2), the sterile gauze is more than two layers.
Preferably, in the step (2), the ratio of the ginger juice to the water is 1: 0.5-1.
Preferably, in the step (3), the raw material powder and the ginger juice solution are mixed according to the mass volume ratio of 0.5-1 g/ml.
Has the advantages that:
the traditional Chinese medicine smell applied to the invention enters skin striae and Yu points, then enters Sun veins and collaterals, enters channels, runs along with qi and blood, reaches viscera internally, spreads on the whole body, can play a role in regulating the human body by the meridian and the Yu points, and can achieve the effects of regulating qi and blood yin and yang of viscera, strengthening body resistance to eliminate pathogenic factors, nourishing vitality and tonifying qi, warming spleen and tonifying kidney, warming kidney and tonifying yang, activating blood and dissolving stasis, warming channels and relieving pain, treating inflammation, relieving pain and the like.
Drawings
The foregoing and/or other advantages of the invention will become further apparent from the following detailed description of the invention when taken in conjunction with the accompanying drawings.
Fig. 1 is a structural view of the self-heating acupuncture point application used in the present invention.
Detailed Description
The invention will be better understood from the following examples.
Example 1
15g of cassia twig, 15g of angelica dahurica, 10g of clove, 10g of cinnamon, 10g of white peony root, 10g of honey-fried licorice root, 8g of prepared aconite accessory tuber, 8g of prepared nutgrass galingale rhizome, 8g of galangal, 8g of evodia rutaecarpa, 8g of katsumade galangal seed, 5g of tangerine peel, 5g of common fennel fruit, 5g of paniculate swallowwort root, 5g of szechuan lovage rhizome, 3g of combined spicebush root, 3g of Chinese mugwort leaf and 3g of perilla leaf.
The specific preparation process comprises the following steps:
(1) drying the raw materials, crushing the raw materials together, and sieving the crushed raw materials with a 140-mesh sieve to obtain raw material powder;
(2) cleaning ginger, crushing, squeezing with three layers of sterile gauze to obtain ginger juice, and adding 1 volume of water to obtain ginger juice solution;
(3) and (3) mixing the raw material powder in the step (1) with the ginger juice solution in the step (2) according to the mass volume ratio of 1g/ml, and finally blending the mixture into a dry thick paste by using medical hot melt adhesive.
Example 2
20g of cassia twig, 20g of angelica dahurica, 12g of clove, 12g of cinnamon, 12g of white peony root, 12g of honey-fried licorice root, 10g of prepared aconite accessory tuber, 10g of prepared nutgrass galingale rhizome, 10g of galangal, 10g of evodia rutaecarpa, 10g of katsumade galangal seed, 8g of tangerine peel, 8g of common fennel fruit, 8g of paniculate swallowwort root, 8g of szechuan lovage rhizome, 5g of combined spicebush root, 5g of Chinese mugwort leaf and 5g of perilla leaf.
The specific preparation process comprises the following steps:
(1) drying the raw materials, crushing the dried raw materials together, and sieving the crushed raw materials with a 120-mesh sieve to obtain raw material powder;
(2) cleaning rhizoma Zingiberis recens, pulverizing, squeezing with three layers of sterile gauze to obtain juice, adding 1 volume of water to obtain rhizoma Zingiberis recens juice solution;
(3) mixing the raw material powder in the step (1) and the ginger juice solution in the step (2) according to the mass-to-volume ratio of 0.5g/ml, and finally blending the mixture into a dry thick paste by using medical hot melt adhesive.
Example 3
10g of cassia twig, 10g of angelica dahurica, 6g of clove, 6g of cinnamon, 6g of white peony root, 6g of honey-fried licorice root, 4g of prepared aconite accessory tuber, 4g of prepared nutgrass galingale rhizome, 4g of galangal, 4g of evodia rutaecarpa, 4g of katsumade galangal seed, 2g of tangerine peel, 2g of common fennel fruit, 2g of paniculate swallowwort root, 2g of szechuan lovage rhizome, 2g of combined spicebush root, 2g of Chinese mugwort leaf and 2g of perilla leaf.
The specific preparation process comprises the following steps:
(1) drying the raw materials, crushing the dried raw materials together, and sieving the crushed raw materials with a 90-mesh sieve to obtain raw material powder;
(2) cleaning rhizoma Zingiberis recens, pulverizing, squeezing with two layers of sterile gauze to obtain juice, adding 0.5 times of water to obtain rhizoma Zingiberis recens juice solution;
(3) mixing the raw material powder in the step (1) and the ginger juice solution in the step (2) according to the mass-volume ratio of 0.8g/ml, and finally blending the mixture into a dry thick paste by using medical hot melt adhesive.
The pasty traditional Chinese medicine composition prepared in example 1 is put into a small bag, is put into a pasting ring in the self-heating acupoint plaster shown in figure 1, and is pasted on the acupoints of the shoulder, back, waist, stomach and related joints of a human body, so that the medicine can be uniformly heated for a long time, the absorption is promoted, and the curative effect of medicine permeation and absorption is improved.
The self-heating acupoint plaster is a sheet patch, and consists of four parts, namely a pasting ring 7, an adhesive layer, a non-woven fabric bag 6 and a low-temperature continuous self-heating material 5, and has standard sizes: (1) small size: the length is 90mm, the width is 60mm, and the diameter of the inner ring is 28 mm; (2) large size: the length is 120mm, the width is 90mm, the length of the inner ring is 100mm, and the width of the inner ring is 75 mm.
The pasting ring 7 is composed of high-grade skin-friendly silicone foam, the double-side adhesive layers are made of special high-quality pressure-sensitive adhesive coatings in Japan, the pasting is firm, the clothes are not stained, and the skin is not damaged. The skin-friendly layer is on the outer layer of the left nonwoven 1. Three layers of high-quality non-woven fabrics 2-4 are arranged between the self-heating material 5. The self-heating material is placed in the non-woven fabric bag, is a polymer synthesized by iron powder (42 wt%), stone needle (38 wt%), activated carbon (18 wt%), inorganic salt, water and the like, is non-toxic and free of side effect, and can perform an exothermic reaction under the action of oxygen in the air. Lasting for 4-6 h, controlling the temperature to be about 40-45 ℃, and slowly transmitting heat.
When in use, the lining paper is peeled off, the applied medicine is put into the application ring and is pasted on the shoulder, the back, the waist, the stomach and related joint acupuncture points of the human body, and the adhesive layer is directly pasted on the skin of the human body and is paved by hands. The maximum heating temperature of the self-heating application is 40-45 ℃, and the self-heating application can uniformly release heat for 4-6 h. After the use, the skin care product can be gently torn off from the skin, and the skin and clothes are never stained.
The use curative effect is as follows:
clinical data:
general data: 104 patients in outpatients of the home hospital in 3-2020 3 in 2019 are selected, and the patients are randomly divided into 2 groups by adopting a random number table method. Treatment groups 53, 27 men and 26 women; age 57-82 years, mean (66.23 ± 8.50) years; the course of disease is 3-10 months, and the average (8.15 +/-3.45) months. Control group 51, 25 men and 26 women; the age is 56-81 years, and the average (67.20 +/-7.92) years; the disease course is 3-10 months, and the average (8.20 +/-3.50) months. The data of sex, age, course of disease, etc. of the 2 groups are statistically processed, and the differences have no significant meaning (P >0.05) and are comparable.
Diagnostic criteria: refer to the diagnostic criteria of knee osteoarthritis and the guidelines for diagnosing and treating osteoarthritis (2007 edition), which are the guidelines: firstly, knee joint pain repeatedly occurs in nearly 1 month; knee joint X-ray film showing: joint margin osteophyte formation, narrow joint space; ③ joint swelling is increased; morning stiffness; age greater than 40 years old; sixthly, bone rubbing feeling (sound) occurs during movement. Satisfy the requirements of (1) patients who do not use other medicines and other methods for treatment in nearly 1 week, or (iii), (iv) and then can be diagnosed.
Inclusion criteria were:
(1) meets the diagnosis standard of knee osteoarthritis.
(2) The treatment period can be in compliance with the physician's advice.
(3) Signing the informed consent.
Exclusion criteria:
(1) x-ray film shows: the joint space is significantly narrowed; the internodal bone bridges.
(2) Acute trauma, knee joint tumor, tuberculosis, and rheumatoid arthritis
Therapeutic criteria and treatment outcome:
the curative effect standard is as follows: the recipe is drawn up according to the standard of curative effect of diagnosis of traditional Chinese medicine diseases.
And (3) healing: the bone joint pain disappears, and the joint moves normally;
the effect is shown: most of bone and joint pain disappears, no obvious pressure pain point exists, and the joint function is basically normal;
the method has the following advantages: slight bone and joint pain exists, and the joint function is partially recovered;
and (4) invalidation: bone and joint pain did not improve and joint function did not recover.
The treatment method comprises the following steps:
the treatment group is treated by the self-heating acupoint application traditional Chinese medicine combination external application in the embodiment 1. The Chinese medicine prescription is as follows: 15g of cassia twig, 15g of angelica dahurica, 10g of clove, 10g of cinnamon, 10g of white peony root, 10g of honey-fried licorice root, 8g of prepared aconite accessory tuber, 8g of prepared nutgrass galingale rhizome, 8g of galangal, 8g of evodia rutaecarpa, 8g of katsumade galangal seed, 5g of tangerine peel, 5g of common fennel fruit, 5g of paniculate swallowwort root, 5g of szechuan lovage rhizome, 3g of combined spicebush root, 3g of Chinese mugwort leaf and 3g of perilla leaf. The plaster is applied to the affected knee part 1 day for 1 month as 1 course of treatment. The treatment effect is counted after 2 treatment courses.
The control group orally administered loxoprofen sodium tablet (SANCH, manufactured by XING' AN pharmacy Co., Ltd., state drug standard H20041143) 60mg each time 3 times a day. Hot towel is used in combination with hot water bag for local hot compress 2 times per day for 30min each time. 1 month is 1 course of treatment. The treatment effect is counted after 2 treatment courses.
The statistical method comprises the following steps: statistical analysis was performed using the SPSS13.0 software package. The measurement data are expressed as (x +/-s), and the comparison among groups adopts a t test; the counting data were examined by X2.
Group curative effect comparison: see table 1. The total effective rate of the treatment group is 94.34%, the control group is 78.43%, and the total effective rate of the 2 groups is compared, and the difference has significant significance (P is less than 0.05).
TABLE 12 comparative examples of therapeutic effects
Figure BDA0002475786270000121
"*": p is less than 0.05 compared with the control group.
Discussion:
knee osteoarthritis is a degenerative joint disease, and is characterized mainly by degenerative changes of articular cartilage and secondary hyperosteogeny. The knee osteoarthritis belongs to the fields of traditional Chinese medicine bone rheumatism and wind-cold-dampness arthralgia, and is a common bone arthropathy in old people. "Su Wen & Chang Ci Jie Lun" (Su Wen & Long spine festival): the disease is in bones, the weight of bones cannot be lifted, bone marrow is sore and painful, and the disease is known as bone impediment. The 'Su Wen & Yin Yang correspondence theory' is in the legend: the kidney-derived marrow … … is bone in vivo and kidney in viscera. "it is seen that the osteoarthritis of knee joint is located in bone and closely related to liver and kidney. The pathogenesis of the disease is liver and kidney deficiency, viscera dysfunction, inability of generating essence and blood, deficiency of qi and blood, easy blood stasis caused by deficiency of qi and blood, and easy invasion of wind-cold-dampness pathogen when the pathogen is still deficient. Therefore, the disease is characterized by deficiency of the origin with excess of the origin, deficiency of the liver and kidney, and obstruction of qi and blood due to wind-cold-dampness, blood stasis and obstruction of meridians. Just as in "treatment of symptoms and regulations" cloud: wind, cold, contusion, blood stasis, phlegm accumulation, excess, kidney deficiency, also the root cause. Aiming at the pathogenesis characteristics of the deficiency and excess, the prescription is combined by adopting the principles of warming middle-jiao to dispel cold, promoting blood circulation and removing obstruction in channels, so as to take the effects of treating both manifestation and root cause of disease, tonifying deficiency and reducing excess, and also has the effects of nourishing blood, promoting blood circulation, relaxing tendons and activating collaterals. Although the medicine has simple taste, the compatibility is precise and appropriate, and the curative effect is better.
Research results show that the self-heating acupoint application traditional Chinese medicine combination for treating knee osteoarthritis can expand knee blood vessels, improve and accelerate local blood microcirculation, enhance joint metabolism, and facilitate the repair and regeneration of articular cartilage tissues, has better curative effect than oral loxoprofen sodium tablets and hot towels matched with hot water bags for local hot compress, is a safe and effective treatment means, and is worthy of popularization.
The invention provides a thought and a method for self-heating acupoint application of a traditional Chinese medicine composition, and a plurality of methods and ways for realizing the technical scheme are provided, the above description is only a preferred embodiment of the invention, and it should be noted that for a person skilled in the art, a plurality of improvements and decorations can be made without departing from the principle of the invention, and the improvements and decorations should also be regarded as the protection scope of the invention. All the components not specified in the present embodiment can be realized by the prior art.

Claims (7)

1. A self-heating acupoint application traditional Chinese medicine composition is characterized by being prepared from the following raw material medicines in parts by weight:
10-20 parts of Sichuan cassia twig,
10-20 parts of radix angelicae dahuricae,
6-12 parts of clove, namely,
6-12 parts of cinnamon, namely,
6-12 parts of white paeony root,
6-12 parts of honey-fried licorice root,
4 to 10 parts of auxiliary pieces are prepared,
4-10 parts of prepared rhizoma cyperi,
4 to 10 parts of galangal, by weight,
4-10 parts of fructus evodiae,
4-10 parts of katsumade galangal seed,
2-8 parts of dried orange peel,
2-8 parts of fennel fruit,
2-8 parts of paniculate swallowwort root,
2-8 parts of ligusticum wallichii, including,
2-5 parts of radix linderae,
2-5 parts of folium artemisiae argyi,
2-5 parts of perilla leaves.
2. The self-heating acupoint application traditional Chinese medicine composition according to claim 1, which is prepared from the following raw material medicines in parts by weight:
15 parts of Sichuan cassia twig, prepared rehmannia root,
15 parts of dahurian angelica root, radix angelicae dahuricae,
10 parts of clove, namely clove,
10 parts of cinnamon, namely 10 parts of cinnamon,
10 parts of white paeony root, namely white paeony root,
10 parts of honey-fried licorice root, radix glycyrrhizae preparata,
8 parts of accessory pieces are prepared,
8 parts of prepared nutgrass galingale rhizome,
8 parts of galangal, namely 8 parts of galangal,
8 parts of fructus evodiae, namely fructus evodiae,
8 parts of katsumade galangal seed, namely,
5 parts of dried orange peel, namely dried orange peel,
5 parts of fennel fruit, namely fennel,
5 parts of paniculate swallowwort root,
5 parts of ligusticum wallichii, namely,
3 parts of radix linderae, namely,
3 parts of folium artemisiae argyi, namely 3 parts of folium artemisiae argyi,
and 3 parts of perilla leaves.
3. The preparation method of the self-heating acupoint application traditional Chinese medicine composition according to claim 1 or 2, which is characterized by comprising the following steps:
(1) drying the raw materials, and pulverizing together to obtain raw medicinal powder;
(2) cleaning rhizoma Zingiberis recens, pulverizing, squeezing with sterile gauze to obtain juice, and adding water to obtain rhizoma Zingiberis recens juice solution;
(3) mixing the medicinal powder of the raw material in the step (1) with the ginger juice solution in the step (2), and finally blending the mixture into a dry thick paste by using medical hot melt adhesive.
4. The preparation method of the self-heating acupoint-applied traditional Chinese medicine composition according to claim 3, wherein in the step (1), the crushed raw material medicines are sieved by a sieve of 90-140 meshes to obtain raw material medicinal powder.
5. The method for preparing a self-heating acupoint-applied Chinese medicinal composition according to claim 3, wherein in step (2), the sterile gauze has two or more layers.
6. The method for preparing a self-heating acupoint-applied traditional Chinese medicine composition according to claim 3, wherein in the step (2), the volume ratio of the ginger juice to water is 1: 0.5-1.
7. The method for preparing a self-heating acupoint-applied traditional Chinese medicine composition according to claim 3, wherein in the step (3), the raw material powder and the ginger juice solution are mixed according to a mass-to-volume ratio of 0.5-1 g/ml.
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