CN105902976A - Chinese medicinal emplastrum for treatment of knee joint replacement postoperative swelling and pain and preparation method thereof - Google Patents
Chinese medicinal emplastrum for treatment of knee joint replacement postoperative swelling and pain and preparation method thereof Download PDFInfo
- Publication number
- CN105902976A CN105902976A CN201610230844.4A CN201610230844A CN105902976A CN 105902976 A CN105902976 A CN 105902976A CN 201610230844 A CN201610230844 A CN 201610230844A CN 105902976 A CN105902976 A CN 105902976A
- Authority
- CN
- China
- Prior art keywords
- parts
- phase
- pain
- swelling
- emplastrum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 208000002193 Pain Diseases 0.000 title claims abstract description 46
- 230000036407 pain Effects 0.000 title claims abstract description 46
- 230000008961 swelling Effects 0.000 title claims abstract description 40
- 206010042674 Swelling Diseases 0.000 title claims abstract description 39
- 230000002980 postoperative effect Effects 0.000 title claims abstract description 24
- 238000002360 preparation method Methods 0.000 title claims description 10
- 210000000629 knee joint Anatomy 0.000 title abstract description 21
- 239000003814 drug Substances 0.000 claims abstract description 27
- 235000003143 Panax notoginseng Nutrition 0.000 claims abstract description 14
- 241000180649 Panax notoginseng Species 0.000 claims abstract description 14
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 12
- 229940079593 drug Drugs 0.000 claims abstract description 9
- 244000012797 Desmodium caudatum Species 0.000 claims abstract 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 18
- 241000628997 Flos Species 0.000 claims description 17
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 15
- 210000003127 knee Anatomy 0.000 claims description 14
- 210000000582 semen Anatomy 0.000 claims description 14
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 claims description 12
- 239000012567 medical material Substances 0.000 claims description 12
- 239000011505 plaster Substances 0.000 claims description 12
- 238000003756 stirring Methods 0.000 claims description 9
- 239000000341 volatile oil Substances 0.000 claims description 9
- 239000000284 extract Substances 0.000 claims description 8
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 6
- 229910021502 aluminium hydroxide Inorganic materials 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 238000005325 percolation Methods 0.000 claims description 6
- 235000002906 tartaric acid Nutrition 0.000 claims description 6
- 239000011975 tartaric acid Substances 0.000 claims description 6
- 238000011084 recovery Methods 0.000 claims description 5
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 4
- 230000006837 decompression Effects 0.000 claims description 4
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 3
- 238000013019 agitation Methods 0.000 claims description 3
- 239000006286 aqueous extract Substances 0.000 claims description 3
- 239000012141 concentrate Substances 0.000 claims description 3
- 239000003431 cross linking reagent Substances 0.000 claims description 3
- 238000007872 degassing Methods 0.000 claims description 3
- 238000001704 evaporation Methods 0.000 claims description 3
- 239000000706 filtrate Substances 0.000 claims description 3
- 239000012530 fluid Substances 0.000 claims description 3
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 3
- 229910001679 gibbsite Inorganic materials 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 3
- 239000004745 nonwoven fabric Substances 0.000 claims description 3
- 239000002904 solvent Substances 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 238000003809 water extraction Methods 0.000 claims description 3
- 235000008534 Capsicum annuum var annuum Nutrition 0.000 claims 1
- 240000008384 Capsicum annuum var. annuum Species 0.000 claims 1
- 208000006820 Arthralgia Diseases 0.000 abstract description 6
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 abstract 1
- 244000020518 Carthamus tinctorius Species 0.000 abstract 1
- 235000003255 Carthamus tinctorius Nutrition 0.000 abstract 1
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 abstract 1
- 241000514824 Cyathula officinalis Species 0.000 abstract 1
- 240000007890 Leonurus cardiaca Species 0.000 abstract 1
- 235000000802 Leonurus cardiaca ssp. villosus Nutrition 0.000 abstract 1
- 241000913745 Spatholobus Species 0.000 abstract 1
- 241000301400 Trogopterus Species 0.000 abstract 1
- 244000178320 Vaccaria pyramidata Species 0.000 abstract 1
- 235000010587 Vaccaria pyramidata Nutrition 0.000 abstract 1
- 244000089698 Zanthoxylum simulans Species 0.000 abstract 1
- 244000273928 Zingiber officinale Species 0.000 abstract 1
- 235000006886 Zingiber officinale Nutrition 0.000 abstract 1
- 229940116229 borneol Drugs 0.000 abstract 1
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 abstract 1
- 230000003467 diminishing effect Effects 0.000 abstract 1
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 abstract 1
- 210000003608 fece Anatomy 0.000 abstract 1
- 235000008397 ginger Nutrition 0.000 abstract 1
- 239000001525 mentha piperita l. herb oil Substances 0.000 abstract 1
- 235000019477 peppermint oil Nutrition 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 description 15
- 239000008280 blood Substances 0.000 description 15
- 241001438937 Ohwia caudata Species 0.000 description 11
- 230000000694 effects Effects 0.000 description 9
- 230000017531 blood circulation Effects 0.000 description 8
- 210000004185 liver Anatomy 0.000 description 8
- 238000011883 total knee arthroplasty Methods 0.000 description 7
- 206010030113 Oedema Diseases 0.000 description 6
- 201000010099 disease Diseases 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 230000000474 nursing effect Effects 0.000 description 6
- 230000001737 promoting effect Effects 0.000 description 6
- 208000027418 Wounds and injury Diseases 0.000 description 5
- 230000006378 damage Effects 0.000 description 5
- 210000003141 lower extremity Anatomy 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 210000003462 vein Anatomy 0.000 description 5
- 208000005171 Dysmenorrhea Diseases 0.000 description 4
- 206010013935 Dysmenorrhoea Diseases 0.000 description 4
- 210000001015 abdomen Anatomy 0.000 description 4
- 235000009508 confectionery Nutrition 0.000 description 4
- 208000014674 injury Diseases 0.000 description 4
- 230000033001 locomotion Effects 0.000 description 4
- 210000003205 muscle Anatomy 0.000 description 4
- 210000002784 stomach Anatomy 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 201000000736 Amenorrhea Diseases 0.000 description 3
- 206010001928 Amenorrhoea Diseases 0.000 description 3
- 206010011224 Cough Diseases 0.000 description 3
- 206010062717 Increased upper airway secretion Diseases 0.000 description 3
- 208000004880 Polyuria Diseases 0.000 description 3
- 206010052428 Wound Diseases 0.000 description 3
- 231100000540 amenorrhea Toxicity 0.000 description 3
- 230000035619 diuresis Effects 0.000 description 3
- 210000003414 extremity Anatomy 0.000 description 3
- 230000001939 inductive effect Effects 0.000 description 3
- 210000003734 kidney Anatomy 0.000 description 3
- 238000013150 knee replacement Methods 0.000 description 3
- 230000005906 menstruation Effects 0.000 description 3
- 208000026435 phlegm Diseases 0.000 description 3
- 230000008673 vomiting Effects 0.000 description 3
- 208000004998 Abdominal Pain Diseases 0.000 description 2
- 206010007247 Carbuncle Diseases 0.000 description 2
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 2
- 206010010904 Convulsion Diseases 0.000 description 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
- 208000015817 Infant Nutrition disease Diseases 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- 208000025865 Ulcer Diseases 0.000 description 2
- 206010047700 Vomiting Diseases 0.000 description 2
- 230000036592 analgesia Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 230000036461 convulsion Effects 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 230000008407 joint function Effects 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 230000002175 menstrual effect Effects 0.000 description 2
- 210000004417 patella Anatomy 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 210000004872 soft tissue Anatomy 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 238000012549 training Methods 0.000 description 2
- 230000008736 traumatic injury Effects 0.000 description 2
- 238000001291 vacuum drying Methods 0.000 description 2
- 238000010792 warming Methods 0.000 description 2
- 206010007710 Cartilage injury Diseases 0.000 description 1
- 206010008190 Cerebrovascular accident Diseases 0.000 description 1
- 206010009346 Clonus Diseases 0.000 description 1
- 206010010726 Conjunctival oedema Diseases 0.000 description 1
- 206010011878 Deafness Diseases 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 208000034507 Haematemesis Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 208000004044 Hypesthesia Diseases 0.000 description 1
- 206010021118 Hypotonia Diseases 0.000 description 1
- 208000006877 Insect Bites and Stings Diseases 0.000 description 1
- 208000012659 Joint disease Diseases 0.000 description 1
- 208000032912 Local swelling Diseases 0.000 description 1
- 208000019255 Menstrual disease Diseases 0.000 description 1
- 206010027514 Metrorrhagia Diseases 0.000 description 1
- 241000475481 Nebula Species 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 206010030302 Oliguria Diseases 0.000 description 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- 208000018525 Postpartum Hemorrhage Diseases 0.000 description 1
- 201000002154 Pterygium Diseases 0.000 description 1
- 208000025747 Rheumatic disease Diseases 0.000 description 1
- 241000168254 Siro Species 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 208000026062 Tissue disease Diseases 0.000 description 1
- 206010053476 Traumatic haemorrhage Diseases 0.000 description 1
- 208000003443 Unconsciousness Diseases 0.000 description 1
- 206010047139 Vasoconstriction Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 238000005273 aeration Methods 0.000 description 1
- 230000037006 agalactosis Effects 0.000 description 1
- 210000003423 ankle Anatomy 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 208000002399 aphthous stomatitis Diseases 0.000 description 1
- 230000001510 arthropathic effect Effects 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 201000009361 ascariasis Diseases 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 244000309466 calf Species 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 206010010121 compartment syndrome Diseases 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000013480 data collection Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 238000001827 electrotherapy Methods 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 208000001780 epistaxis Diseases 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000010579 first pass effect Methods 0.000 description 1
- 208000017561 flaccidity Diseases 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 208000035861 hematochezia Diseases 0.000 description 1
- 208000006750 hematuria Diseases 0.000 description 1
- 208000014617 hemorrhoid Diseases 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 208000021760 high fever Diseases 0.000 description 1
- 210000004394 hip joint Anatomy 0.000 description 1
- 229960001340 histamine Drugs 0.000 description 1
- 208000034783 hypoesthesia Diseases 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 210000004969 inflammatory cell Anatomy 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000008338 local blood flow Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000004880 lymph fluid Anatomy 0.000 description 1
- 210000001365 lymphatic vessel Anatomy 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 208000004396 mastitis Diseases 0.000 description 1
- 230000005499 meniscus Effects 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 201000009240 nasopharyngitis Diseases 0.000 description 1
- 201000008383 nephritis Diseases 0.000 description 1
- 230000037311 normal skin Effects 0.000 description 1
- 231100000862 numbness Toxicity 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 210000003516 pericardium Anatomy 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 230000000552 rheumatic effect Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000008326 skin blood flow Effects 0.000 description 1
- 206010040872 skin infection Diseases 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 206010042772 syncope Diseases 0.000 description 1
- 201000004595 synovitis Diseases 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 208000004371 toothache Diseases 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
- 230000025033 vasoconstriction Effects 0.000 description 1
- 230000024883 vasodilation Effects 0.000 description 1
- 210000001048 venom Anatomy 0.000 description 1
- 239000002435 venom Substances 0.000 description 1
- 231100000611 venom Toxicity 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 210000004916 vomit Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/24—Mucus; Mucous glands; Bursa; Synovial fluid; Arthral fluid; Excreta; Spinal fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/486—Millettia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/533—Leonurus (motherwort)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/758—Zanthoxylum, e.g. pricklyash
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Zoology (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a Chinese medicinal emplastrum for treatment of knee joint replacement postoperative swelling and pain. The Chinese medicinal emplastrum comprises the following crude drugs by weight: 10-15 parts of safflower, 5-10 parts of Cowherb Seed, 5-15 parts of trogopterus dung, 9-15 parts of Suberect Spatholobus Stem, 3-8 parts of Chinese prickly ash, 5-10 parts of Cyathula officinalis root, 15-30 parts of motherwort, 5-10 parts of panax notoginseng, 3-5 parts of ginger, 20-30 parts of Desmodium caudatum, 10-20 parts of borneol, and 5-10 parts of peppermint oil. The prepared emplastrum can be externally applied to swelling and painful knee joints, can rapidly reach the efficacy of diminishing swelling and relieving pain, and is conducive to rapid rehabilitation after artificial joint replacement.
Description
Technical field
The present invention relates to a kind of traditional Chinese medicine plaster treating the postoperative swelling pain of knee prosthesis and preparation method thereof,
Belong to traditional Chinese medicine field.
Background technology
Knee joint is one of most important organ of locomotion of human body, and its noneffective rate is the highest.Long campaigns weight muscle power labor
Dynamic, the people of violent bounce motion, it is easy to damage knee joint, such as synovitis, ligamentaum cruciatum tear, meniscus
Damage, cartilage injury etc..It should be noted that now because the incidence rate such as longevity, obesity, wound rises, knee joint
Joint disease sickness rate is more and more higher.This respect disease belongs to stubborn disease clinically, does not has what specially good effect
Medicine, can only take the Therapeutic Method having an operation.Artificial knee joint replacement is in artificial hip joint successful Application in modern age
A kind of new technique treating diseases of knee joint gradually grown up after patient Yu, it can effectively be eradicated evening
Phase knee joint is ailing, is greatly enhanced the quality of life of patient, popular in developed country.
The whole latter stage (pain, dysfunction etc.) of nearly all diseases of knee joint must be put by artificial knee joint
Change art (TKA) to solve.The theory of TKA, is to cut operative incision in knee joint position, by femur, shin
The part osteotomy system that the bonding station of bone is unnecessary is clipped, and then loads onto the prosthese coordinated with section, thus complete
Become artificial knee joint replacement, reach treatment, the purpose corrected, the wherein position of the skeleton that osteotomy system is to be clipped
Put, the degree of depth, then determined by alignment system.Conventional TKA is curative effect in terms of alleviating arthralgia and Reconstruction of The Function
Basic affirmative.But its postoperative easy swelling pain, the inflammation such as main cause is, the histamine discharged in damage tissue
Disease medium, causes vasodilation, permeability to increase and inflammatory cell oozes out；The tissue blood vessel of the broken ends of fractured bone, lymphatic vessel
Deng rupturing of tissue, cause blood and lymph fluid flow out or ooze out, accumulate in interstice, be difficult to dissipate in time；
Simultaneously as pain and muscle reflexive spasm, cause venous return obstacle, add re-organized interstitial edema.This
If a little complication are corrected not in time, will affect postoperative limb function, severe one can cause local skin blood circulation
Obstacle, makes otch skin edge downright bad, affects the healing of otch, be then greatly increased the probability of infection of incisional wound.Cause
This, prevent and treat swelling, pain particularly significant.
The method controlling swelling at present mainly has: (1) wears stretch socks.Stretch socks set by the barometric gradient of specialty
Meter, pressure is the most upwards successively decreased by ankle, pressurizes lumen of vessels by shrinking Calf muscle, promotes venous blood
Liquid backflow heart, prevents veins of lower extremity congestion, it is ensured that the good circulation of veins of lower extremity blood, promotion suffering limb swelling,
The disappearance of the symptoms such as pain.(2) cold treatment.After range of motion training, carry out 10～15min knee joints
Ice compress, can make vasoconstriction, and cell-permeant sexually revises, and local is oozed out and hemorrhage minimizing, and local inflammation edema subtracts
Few.(3) electrotherapy.By two-way electric current of intermediate frequency by four electrode crossing input human bodies, (sick at infall
Stove position) form interference field, produce electric current, reach analgesia, improve local blood circulation, the effect of elimination swelling
Really.(4) veins of lower extremity pump.Use effective fast aeration and gradually compress the veins of lower extremity pump combined continuously
Method, it is possible to substantially accelerate the blood flow rate of vein blood vessel, eliminates swelling.
All there is certain defect in said method, therapeutic effect is not extremely to be satisfied with.Therefore, Chinese medicine is utilized
Strong point, the Chinese medicine of the research and development treatment postoperative swelling pain of knee prosthesis is extremely necessary targetedly.
Summary of the invention
It is an object of the invention to the deficiency overcome in traditional treatment, it is provided that it is postoperative swollen that one treats knee prosthesis
The traditional Chinese medicine plaster of swollen pain and compound method thereof, determined curative effect, it is greatly facilitated postoperative rehabilitation.
Technical solution of the present invention is as follows: a kind of traditional Chinese medicine plaster treating the postoperative swelling pain of knee prosthesis, with
Weight portion meter, including the crude drug of following components, Flos Carthami 10-15 part, Semen Vaccariae 5-10 part, Oletum Trogopterori
5-15 part, Caulis Spatholobi 9-15 part, Pericarpium Zanthoxyli 3-8 part, Radix Cyathulae 5-10 part, Herba Leonuri 15-30 part, three
Seven 5-10 parts, Rhizoma Zingiberis Recens 3-5 part, Desmodium caudatum (Thunb.) DC. 20-30 part, Borneolum Syntheticum 10-20 part, Oleum menthae 5-10 part.
Preparation method of the present invention is as follows:
(1) medicinal material extract
1. Semen Vaccariae, Oletum Trogopterori, Caulis Spatholobi, Radix Cyathulae, Herba Leonuri, Radix Notoginseng, Desmodium caudatum (Thunb.) DC. are pulverized respectively
Cross 20 mesh sieves, after adding 75% ethanol wet of medical material amount 1 times, airtight, place 1 hour；Then with 1ml/min
Speed percolation, the total amount of percolate is 14 times of medical material amounts；After percolation is complete, decompression and solvent recovery to 2 times volume,
Pouring water-bath in evaporating dish into concentrate, be concentrated into small size vacuum drying, dried micronizing is to 300 mesh；
2. Pericarpium Zanthoxyli, Flos Carthami pulverize the water adding medical material amount 8 times amount respectively, extract volatile oil, are collected by volatile oil
Standby；Aqueous extracts is concentrated to be equivalent to 1-2 times of medical material after filtering, and 60% ethanol sinks 24 hours, and alcohol deposit fluid subtracts
Pressure sucking filtration, filtrate is concentrated to paste, is vacuum dried 48 hours, and micronizing is to 300 mesh；
3. Rhizoma Zingiberis Recens extracting juice is standby；
(2) prepared by emplastrum
1. by A phase (NP700, glycerol, aluminium hydroxide) magnetic agitation uniformly rear ultrasonic degassing；By D phase
(Borneolum Syntheticum, Pericarpium Zanthoxyli, Flos Carthami volatile oil) adds A phase and stirs；
2. by C phase, (Semen Vaccariae, Oletum Trogopterori, Caulis Spatholobi, Radix Cyathulae, Herba Leonuri, Radix Notoginseng, Desmodium caudatum (Thunb.) DC. carry
Take thing, and Pericarpium Zanthoxyli, Flos Carthami water extraction, Sucus Zingberis) after mix homogeneously, add A phase, D phase stirs, super
Sound de-bubbled；
3. by after B phase (tartaric acid, aluminum chloride) mix homogeneously, add A, D, C phase, stir to proper viscosity
After be laid on non-woven fabrics, 70 DEG C are dried cold after 2 hours putting, add and cover separate paper；
Wherein, described NP700: glycerol: tartaric acid: cross-linking agent (AlCl3:Al(OH)3Weight ratio is
2:8:0.01(0.01:0.007)。
Emplastrum prepared by the present invention, every 100cm2Average paste containing amount is 20.3-25.6g.
Total knee arthroplasty (TKA) is the treatment arthropathic effective therapy of serious kneecap.Kneecap joint sufferer
Person can obtain alleviation arthralgia, orthotic joint deformity after carrying out TKA, improve knee joint merit
Energy, improve the quality of living etc. acts on.But patient after accepting this operative treatment can because of the gonalgia unbearably and
It is reluctant to carry out functional exercise, hence it is evident that extend the course of disease.Must be effective to carrying out after total knee replacement for this
Nursing.The present inventor finds through Long-term clinical research, will be applied to the knee joint of swelling, pain outside emplastrum of the present invention
Joint, has the carrying out of quick recovery after the effect being rapidly reached reducing swelling and alleviating pain, beneficially artificial joint replacement.
Flos Carthami, Semen Vaccariae, Oletum Trogopterori, Caulis Spatholobi, Pericarpium Zanthoxyli, Radix Cyathulae, Herba Leonuri, Radix Notoginseng, Rhizoma Zingiberis Recens etc. in side
There is effect of blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, add Desmodium caudatum (Thunb.) DC. analgesia antioxidation, enhancing immunity, Borneolum Syntheticum,
Oleum menthae aromatic ventilating siro, walk help medicine gesture.
The most each Chinese medicinal components pharmacological action is as follows:
Flos Carthami: pungent, temperature.GUIXIN, Liver Channel.Promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia
Not all right, lump in the abdomen mass in the abdomen, injury from falling down, skin infection swells and ache.
Semen Vaccariae: bitter is flat.Return liver, stomach warp.Promoting blood circulation to restore menstrual flow, stimulating milk secretion is subsided a swelling.For agalactia, warp
Closing, dysmenorrhea, acute mastitis swells and ache.
Oletum Trogopterori: sweet, temperature.Promoting blood circulation to remove blood stasis, parch to black stops blooding.Have a pain for trusted subordinate's congestion, dysmenorrhea, blood stasis warp
Closing, curing postpartum bleeding is suffered from abdominal pain；Parch to black controls metrostaxis；Traumatic injury, Serpentis, insect bite wound are controlled in external.
Caulis Spatholobi: bitter, sweet, temperature.Return liver, kidney channel.Enrich blood, invigorate blood circulation, dredging collateral.For menoxenia, blood
Empty sallow, paralysis and numbness, rheumatic arthralgia.
Pericarpium Zanthoxyli: pungent, temperature.Return spleen, stomach, kidney channel.Warming middle-JIAO to relieve pain, killing parasites for relieving itching.For coldness and pain in the epigastrium, vomit
Tell and have loose bowels, abdominal pain due to worm stagnation, ascariasis；External treatment eczema pruritus.
Radix Cyathulae: hardship sweet, micro-, flat.Return liver, kidney channel.Eliminating blood stasis and inducing menstruation, easing joint movement, inducing diuresis for treating stranguria syndrome.With
In amenorrhea lump in the abdomen, retention of placenta, arthralgia, flaccidity of the lower limbs clonic spasm of the muscle, hematuria stranguria with blood, injury from falling down.
Herba Leonuri: bitter, pungent, is slightly cold.Return liver, pericardium channel.Promoting blood flow to regulate menstruation, inducing diuresis to remove edema.For menstruation not
Adjust, dysmenorrhea, amenorrhea, lochiorrhea, edema oliguria；Acute nephritis edema.
Radix Notoginseng: hardship sweet, micro-, temperature.Return liver, stomach warp.Dissipating blood stasis stops blooding, subduing swelling and relieving pain.For spitting blood, spit blood,
Epistaxis, has blood in stool, metrorrhagia, traumatic hemorrhage, and chest and abdomen twinge, tumbling and swelling.
Rhizoma Zingiberis Recens: pungent, tepor.Return lung, spleen, stomach warp.Relieving exterior syndrome and dispelling cold, warming middle-JIAO to arrest vomiting, preventing phlegm from forming and stopping coughing.For
Anemofrigid cold, gastrofrigid vomiting, cold-phlegm is coughed.
Desmodium caudatum (Thunb.) DC.: micro-hardship, pungent, flat, clearing away heat-damp and promoting diuresis, removing food stagnancy dissipating blood stasis, reducing swelling and alleviating pain, the haematemesis that is used for coughing,
Edema, infantile malnutrition, ulcerative carbuncle, ulcer, traumatic injury, dysentery, icterohepatitis, the cough due to common cold, children's
Infantile convulsion, ascarifuge, venom etc..
Oleum menthae: dispelling wind；Heat clearing away.Main affection due to external wind and heat；Headache conjunctival congestion；Pharyngalgia；Have a toothache；Skin wind heat.
Borneolum Syntheticum: acrid in the mouth, hardship, is slightly cold；GUIXIN, liver, lung meridian；Heat clearing away dissipates poison, improving acuity of vision and removing nebula, cures mainly heat
Sick unconsciousness due to high fever, apoplexy syncope due to accumulation of phlegm infantile convulsion, heat-damp in summer blinds clear key, and sore throat is deaf, and aphtha tooth swells, carbuncle sore infantile malnutrition hemorrhoid,
Conjunctival congestion and swelling pain, pterygium.
There is advantages that
(1) present invention has the effect being rapidly reached reducing swelling and alleviating pain, is applied to outward the knee joint of swelling, pain,
The symptoms such as affected part blood circulation, prevention of soft tissues adhesion, the swelling pain alleviating affected part can be promoted, make patient's knee joint
Function of joint more quickly restores normally.
(2) present invention uses emplastrum, percutaneous drug absorption to have and avoids liver first-pass effect and in gastrointestinal fall
Solve, can constant speed release medicine and reduce adverse effect, can the advantage such as interruption of the administration at any time.
Below in conjunction with clinical treatment situation, further illustrate the curative effect of the present invention.
In January, 2013 is suffered from my 106 examples of institute's row total knee replacement by we in December, 2015
Person is randomly divided into two groups, and the postoperative medicine of the present invention of observation group carries out integrated Western and Chinese nursing, and matched group patient enter
The postoperative doctor trained in Western medicine nursing that row is conventional.Observe two groups of nursing efficacies.
1. clinical data
In January, 2013 in December, 2015 106 example patients of my institute's row total knee replacement, its
Include male patient 45 example, female patient 61 example, the age in 51-72 year, the mean age is 67.2 ±
5.4 year.Patient has all carried out knee prosthesis treatment, and average stay is 27.9 ± 4.4 days.Random point
For observation group and matched group, each 53 examples, two groups of patient ages, sex, HSS scoring, courses of disease, when being in hospital
Between etc. each side compare, difference is notable, not statistically significant, has comparability.
2. postoperative care
Matched group patient carries out routine care: state of an illness detection, TCM psychiatry nursing, bandage for ice compress, rehabilitation training, drink
Food nursing etc.；Observation group uses Chinese medicinal plaster of the present invention on the basis of carrying out the routine care as matched group
Agent is treated.
3. data collection
3.1 observation index evaluate 2 groups of patient's swelling pain situations record in postoperative 1 day, 3 days, 7 days respectively.
3.1.1 swelling degree evaluation standard
I level: compared with normal skin turgor, but dermatoglyph remains；II level: swelling is more apparent, dermatoglyph disappears, but anhydrous
Bubble；III level: swelling, it is obvious that skin is firmly tight, blister occurs, but without osteofascial compartment syndrome.
3.1.2 pain scores
Visual analogue scales is used to carry out collection of data.0 represents painless, and 1-3 represents mild pain, 4-6
Representing moderate pain, 7-9 represents severe pain, and 10 representatives have an intense pain.
Swelling pain data, through SPS13.0 software processes, use rank test analysis, P ＜ 0.05, it is believed that poor
The most statistically significant.
4. result
See Tables 1 and 2
1 liang of group of table suffers from knee joint local swelling situation comparative example (%) in the 1st, 3,7 days
After 2 liang of table group operation in patients, 3 days limbs local pains compare (example)
P ＜ 0.05
4 discuss
Clinical practice proves, if can control its knee joint after implementing TKA for patient in early days
The symptom of swelling pain can promote it to heal quickly.And affected part blood follows to use treatment by Chinese herbs of the present invention to promote
The symptoms such as ring, prevention of soft tissues adhesion, the swelling pain alleviating affected part, make knee joint function in patients with knee the most extensive
Multiple normal.From clinical observation, after Drug therapy of the present invention 3 days after surgery, swelling situation is significantly better than
Matched group, within postoperative 7 days, have 54.7% recovery normal, and matched group postoperative 7 days only 15.1% recovers normal.
Postoperative 3 days, observation group only 8 example continued severe pain, and matched group has 20 example severe pain and 5 examples violent
Pain.
Detailed description of the invention
In order to make those skilled in the art be more fully understood that the present invention program, below in conjunction with specific embodiment party
The present invention is described in further detail for formula.
Embodiment 1. 1 kinds treats the traditional Chinese medicine plaster of the postoperative swelling pain of knee prosthesis, including following components
Crude drug, 10 grams of Flos Carthami, Semen Vaccariae 5 grams, Oletum Trogopterori 5 grams, Caulis Spatholobi 9 grams, 3 grams of Pericarpium Zanthoxyli,
Radix Cyathulae 5 grams, Herba Leonuri 15 grams, Radix Notoginseng 5 grams, 3 grams of Rhizoma Zingiberis Recens, Desmodium caudatum (Thunb.) DC. 20 grams, Borneolum Syntheticum 10 grams,
Oleum menthae 5 grams.
Preparation method of the present invention is as follows:
(1) medicinal material extract
1. Semen Vaccariae, Oletum Trogopterori, Caulis Spatholobi, Radix Cyathulae, Herba Leonuri, Radix Notoginseng, Desmodium caudatum (Thunb.) DC. are pulverized respectively
Cross 20 mesh sieves, after adding 75% ethanol wet of medical material amount 1 times, airtight, place 1 hour；Then with 1ml/min
Speed percolation, the total amount of percolate is 14 times of medical material amounts；After percolation is complete, decompression and solvent recovery to 2 times volume,
Pouring water-bath in evaporating dish into concentrate, be concentrated into small size vacuum drying, dried micronizing is to 300 mesh；
2. Pericarpium Zanthoxyli, Flos Carthami pulverize the water adding medical material amount 8 times amount respectively, extract volatile oil, are collected by volatile oil
Standby；Aqueous extracts is concentrated to be equivalent to 1-2 times of medical material after filtering, and 60% ethanol sinks 24 hours, and alcohol deposit fluid subtracts
Pressure sucking filtration, filtrate is concentrated to paste, is vacuum dried 48 hours, and micronizing is to 300 mesh；
3. Rhizoma Zingiberis Recens extracting juice is standby；
(2) prepared by emplastrum
1. by A phase NP700, glycerol, aluminium hydroxide, with magnetic agitation uniformly rear ultrasonic degassing；By D
Phase Borneolum Syntheticum, Pericarpium Zanthoxyli, Flos Carthami volatile oil, add A phase and stir；
2. by C phase Semen Vaccariae, Oletum Trogopterori, Caulis Spatholobi, Radix Cyathulae, Herba Leonuri, Radix Notoginseng, Desmodium caudatum (Thunb.) DC.
After extract, and Pericarpium Zanthoxyli, Flos Carthami water extraction, Sucus Zingberis mix homogeneously, add A phase, D phase stirs, super
Sound de-bubbled；
3. by after B phase (tartaric acid, aluminum chloride) mix homogeneously, add A, D, C phase, stir to proper viscosity
After be laid on non-woven fabrics, 70 DEG C are dried cold after 2 hours putting, add and cover separate paper；
Wherein, described NP700: glycerol: tartaric acid: cross-linking agent (AlCl3:Al(OH)3Weight ratio is
2:8:0.01(0.01:0.007)。
Embodiment 2. 1 kinds treats the traditional Chinese medicine plaster of the postoperative swelling pain of knee prosthesis, including following components
Crude drug, 15 grams of Flos Carthami, Semen Vaccariae 10 grams, Oletum Trogopterori 15 grams, Caulis Spatholobi 15 grams, Pericarpium Zanthoxyli 8
Gram, Radix Cyathulae 10 grams, Herba Leonuri 30 grams, Radix Notoginseng 10 grams, 5 grams of Rhizoma Zingiberis Recens, Desmodium caudatum (Thunb.) DC. 30 grams, Borneolum Syntheticum
20 grams, Oleum menthae 10 grams.
Preparation method is with embodiment 1.
Embodiment 3. 1 kinds treats the traditional Chinese medicine plaster of the postoperative swelling pain of knee prosthesis, including following components
Crude drug, 12 parts of Flos Carthami, Semen Vaccariae 8 parts, Oletum Trogopterori 10 parts, Caulis Spatholobi 12 parts, 5 parts of Pericarpium Zanthoxyli,
Radix Cyathulae 7 parts, Herba Leonuri 20 parts, Radix Notoginseng 7 parts, 4 parts of Rhizoma Zingiberis Recens, Desmodium caudatum (Thunb.) DC. 25 parts, Borneolum Syntheticum 15 parts,
Oleum menthae 8 parts.
Preparation method is with embodiment 1.
Embodiment 4. 1 kinds treats the traditional Chinese medicine plaster of the postoperative swelling pain of knee prosthesis, including following components
Crude drug, 11 parts of Flos Carthami, Semen Vaccariae 7 parts, Oletum Trogopterori 13 parts, Caulis Spatholobi 12 parts, 6 parts of Pericarpium Zanthoxyli,
Radix Cyathulae 7 parts, Herba Leonuri 25 parts, Radix Notoginseng 6 parts, 5 parts of Rhizoma Zingiberis Recens, Desmodium caudatum (Thunb.) DC. 30 parts, Borneolum Syntheticum 12 parts,
Oleum menthae 9 parts.
Preparation method is with embodiment 1.
Claims (3)
1. treat a traditional Chinese medicine plaster for the postoperative swelling pain of knee prosthesis, it is characterized in that, in parts by weight, including following
The crude drug of component, Flos Carthami 10-15 part, Semen Vaccariae 5-10 part, Oletum Trogopterori 5-15 part, Caulis Spatholobi 9-15 part, Pericarpium Zanthoxyli 3-8
Part, Radix Cyathulae 5-10 part, Herba Leonuri 15-30 part, Radix Notoginseng 5-10 part, Rhizoma Zingiberis Recens 3-5 part, Desmodium caudatum (Thunb.) DC. 20-30 part, Borneolum Syntheticum
10-20 part, Oleum menthae 5-10 part.
2. treat the preparation method of the traditional Chinese medicine plaster of the postoperative swelling pain of knee prosthesis described in claim 1, it is characterized in that,
Step is as follows:
(1) medicinal material extract
1. Semen Vaccariae, Oletum Trogopterori, Caulis Spatholobi, Radix Cyathulae, Herba Leonuri, Radix Notoginseng, Desmodium caudatum (Thunb.) DC. were pulverized 20 mesh sieves respectively,
After adding 75% ethanol wet of medical material amount 1 times, airtight, place 1 hour；Then with 1ml/min speed percolation, percolate
Total amount is 14 times of medical material amounts；After percolation is complete, decompression and solvent recovery to 2 times volume, pour water-bath in evaporating dish into and concentrate, be concentrated into
Small size is vacuum dried, and dried micronizing is to 300 mesh；
2. Pericarpium Zanthoxyli, Flos Carthami pulverize the water adding medical material amount 8 times amount respectively, extract volatile oil, are collected by volatile oil standby；Aqueous extracts
Being concentrated to be equivalent to 1-2 times of medical material after filtration, 60% ethanol sinks 24 hours, alcohol deposit fluid decompression sucking filtration, and filtrate is concentrated to paste,
Being vacuum dried 48 hours, micronizing is to 300 mesh；
3. Rhizoma Zingiberis Recens extracting juice is standby；
(2) prepared by emplastrum
1. by A phase NP700, glycerol, aluminium hydroxide, with magnetic agitation uniformly rear ultrasonic degassing；By D phase Borneolum Syntheticum,
Pericarpium Zanthoxyli, Flos Carthami volatile oil, add A phase and stir；
2. by C phase Semen Vaccariae, Oletum Trogopterori, Caulis Spatholobi, Radix Cyathulae, Herba Leonuri, Radix Notoginseng, Desmodium caudatum (Thunb.) DC. extract, and flower
After green pepper, Flos Carthami water extraction, Sucus Zingberis mix homogeneously, add A phase, D phase stirs, ultrasonic de-bubbled；
3. by after B phase tartaric acid, aluminum chloride mix homogeneously, add A, D, C phase, stir to proper viscosity and be laid on non-woven fabrics
On, 70 DEG C are dried cold after 2 hours putting, add and cover separate paper.
3. treat the preparation method of the traditional Chinese medicine plaster of the postoperative swelling pain of knee prosthesis as claimed in claim 2, it is characterized in that,
Described NP700: glycerol: tartaric acid: cross-linking agent (AlCl3:Al(OH)3) weight ratio is 2:8:0.01 (0.01:0.007).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610230844.4A CN105902976A (en) | 2016-04-14 | 2016-04-14 | Chinese medicinal emplastrum for treatment of knee joint replacement postoperative swelling and pain and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610230844.4A CN105902976A (en) | 2016-04-14 | 2016-04-14 | Chinese medicinal emplastrum for treatment of knee joint replacement postoperative swelling and pain and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105902976A true CN105902976A (en) | 2016-08-31 |
Family
ID=56746922
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610230844.4A Pending CN105902976A (en) | 2016-04-14 | 2016-04-14 | Chinese medicinal emplastrum for treatment of knee joint replacement postoperative swelling and pain and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105902976A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116196379A (en) * | 2023-03-31 | 2023-06-02 | 刘威 | Traditional Chinese medicine composition for treating pain after artificial knee joint replacement operation and improving functions |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1334121A (en) * | 2001-08-31 | 2002-02-06 | 石家庄以岭药业有限公司 | Medicinal composition for restoring cardiac collaterals and its application |
| CN1973900A (en) * | 2006-12-08 | 2007-06-06 | 四川惠仁康生物技术有限责任公司 | Matrix for Chinese medicine plaster and its prepn |
-
2016
- 2016-04-14 CN CN201610230844.4A patent/CN105902976A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1334121A (en) * | 2001-08-31 | 2002-02-06 | 石家庄以岭药业有限公司 | Medicinal composition for restoring cardiac collaterals and its application |
| CN1973900A (en) * | 2006-12-08 | 2007-06-06 | 四川惠仁康生物技术有限责任公司 | Matrix for Chinese medicine plaster and its prepn |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116196379A (en) * | 2023-03-31 | 2023-06-02 | 刘威 | Traditional Chinese medicine composition for treating pain after artificial knee joint replacement operation and improving functions |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101049430A (en) | External ointment for treating bone fracture | |
| CN100490878C (en) | Traditional Chinese medicine for treating psoriasis | |
| CN110314216A (en) | It is a kind of to treat Bones and joints, plaster of soft tissue disease pain and preparation method thereof | |
| CN104873851A (en) | Internal and external traditional-Chinese-medicine composition for treating bedsore | |
| CN104161823B (en) | A kind of Chinese medicine for the treatment of aseptic necrosis of femoral head | |
| CN103393943B (en) | Traditional Chinese medicine composition for treating sequela of cerebral infarction | |
| CN103223078B (en) | Traditional Chinese medicine used for treating knee osteoarthritis through iontophoresis | |
| CN104147516A (en) | Traditional Chinese medicine formula for treating osteomyelitis | |
| CN104306880A (en) | Formula of traditional Chinese medicine for treating cerebral thrombosis | |
| CN105902976A (en) | Chinese medicinal emplastrum for treatment of knee joint replacement postoperative swelling and pain and preparation method thereof | |
| CN102872362A (en) | Traditional Chinese medicine for treating chronic cholecystitis | |
| CN103055295B (en) | Chinese medicine for treating lumbar disc herniation and hyperosteogeny and use method of Chinese medicine | |
| CN102266435A (en) | Traditional Chinese medicine for treating psoriasis | |
| CN1255165C (en) | Traditional Chinese medicinal preparation for treating iternal-external ulcer and its preparation method | |
| CN104338052A (en) | Formula of traditional Chinese medicine for treating cerebral thrombosis | |
| CN104306741A (en) | A traditional Chinese medicine formula for treating cerebral hemorrhage | |
| CN103356797A (en) | Chinese medicine composition for treating kidney stone | |
| CN108066572A (en) | A kind of plaster for treating gonarthromeningitis and preparation method thereof | |
| CN102935157B (en) | Chinese medicinal ointment for treating closed fracture | |
| CN105343707A (en) | Traditional Chinese medicine used for treating erythema annulare centrifugum | |
| CN105031332A (en) | Traditional Chinese medicine composition for treating milk obstruction caused by internal retention of phlegm and dampness | |
| CN103751397B (en) | A kind of Chinese medicine composition for the treatment of pressure ulcer | |
| CN104274627A (en) | Special traditional Chinese medicine anesthetic for surgery and preparation method thereof | |
| CN103566117A (en) | Ointment for external use for bone-injury hemorrhagic disease and preparation method thereof | |
| CN101347589A (en) | Medicament for treating ovarian cyst |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160831 |