CN105267678A - Traditional Chinese medicine composition for treating osteomyelitis of the jaws - Google Patents

Traditional Chinese medicine composition for treating osteomyelitis of the jaws Download PDF

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CN105267678A
CN105267678A CN201510783714.9A CN201510783714A CN105267678A CN 105267678 A CN105267678 A CN 105267678A CN 201510783714 A CN201510783714 A CN 201510783714A CN 105267678 A CN105267678 A CN 105267678A
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radix
herba
jaws
chinese medicine
osteomyelitis
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CN105267678B (en
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张丽
隋文
邱文霞
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Abstract

The invention relates to the field of traditional Chinese medicine formulations, in particular to a traditional Chinese medicine composition for treating osteomyelitis of the jaws, which is characterized by comprising materials in weight percent: 9-12% of Herba Rabdosiae Rubescentis, 4-7% of Cortex Lycii Radicis, 3-6% of Rhizoma Drynariae, 4-6% of Caulis Impatientis, 5-8% of Herba Polygalae Japonicae, 2-5% of Spina Gleditsiae, 2-4% of Cortex Dictamni, 2-4% of Radix Angelicae Dahuricae, 4-6% of Rhizoma Bletillae, 2-4% of Cortex Acanthopanacis, 2-3% of Galla Chinensis, 4-6% of Halloysitum Rubrum, 4-6% of Radix Trichosanthis, 3-5% of Radix Arnebiae seu Lithospermi, 1-2% of Herba Asari, 3-6% of Rhizoma Polygoni Cuspidati, 2-5% of Herba Orostachyos, 3-5% of Folium et Cacumen Murrayae, 3-6% of Radix Achyranthis Bidentatae, 0.2-1% of Semen Momordicae, 6-9% of Carapax Trionycis, 2-4% of Pseudobulbus Cremastrae seu Pleiones and 1-3% of Radix Sophorae Subprostratae, and the twenty-three medicinal materials are soaked in water and decocted before residue is removed to obtain filtrate. The traditional Chinese medicine composition can treat osteomyelitis of the jaws without causing any toxic and side effects, has high curative efficiency, prevents easy reoccurrence after recovery, and is effective in clearing heat and toxin, activating blood to remove stasis, dredging the channels, tonifying qi and blood, softening hardness to dissipate stagnation, subsiding swelling to expel pus, removing slough and promoting growth of tissue regeneration, and eliminating stagnant blood to arrest pain.

Description

For the Chinese medicine composition of osteomyelitis of jaws
Technical field
The present invention relates to a kind of Chinese patent medicine preparation, specifically a kind of Chinese medicine composition for osteomyelitis of jaws.
Background technology
As everyone knows, osteomyelitis of jaws refers to various virulence factor invasion jawbone, and cause whole osseous tissue to comprise periosteum, cortical bone, bone marrow and blood vessel wherein, neural inflammation, motherland's medical science is called " osteomyelitis of the maxillary bone " or " wearing the cheek ".The difference of jawbone and other skeletons of whole body is there is tooth in jawbone, the suppurative inflammation ordinary wave that odontopathy causes and jawbone, infectious disease due to tooth is a kind of commonly encountered diseases and frequently-occurring disease, and the sickness rate of the osteomyelitis of jaws thus caused by odontopathy etc. is the highest in whole body skeletal system.Pyogenic osteomyelitis of jaws is many by odontogenic infections such as alveolar abscess, periodontitis, pericoronitis of the wisdom tooth, secondly infect because the open injury such as comminuted fracture or firearm injury etc. causes bone to create, by septicemia or pyemia menses infection cycle, the multiple upper jaw bone being born in infant, only a few directly involves jawbone by the infection of facial skin or oral mucosa.Mandibular permanent first molar is more common compared with osteomyelitis of maxilla, also comparatively osteomyelitis of maxilla is serious for the state of an illness, its reason is due to mandibular bone densification, there are fine and close fascia and muscle around, after mandibular bone infects, pus not easily wears out drain, and lower jaw flesh and blood fortune is poor, after metainfective blood vessel embolism, easily form bulk sequestrum.Pathogen is mainly staphylococcus aureus, and be secondly streptococcus, common is mixed infection.By clinicopathological characteristics, pathological changes originates from spongy bone and the bone marrow person of jawbone central authorities, is called central osteomyelitis, and pathological changes originates from periosteum around jawbone and cortical bone person is called marginal osteomyelitis.Acute stage and chronic phase can be divided into by its lesion nature.Topical type or diffusion-type can be divided into by the scope of inflammation.Clinical treatment is mainly with whole body infection application antibiotic, and partial cut drain, pulls out agomphiasis or operation is separated the free sequestrum of excision etc., and course of disease protracted course of disease repeatedly, patient is very painful.
Summary of the invention
Object of the present invention is exactly that provide a kind of Chinese medicine composition for osteomyelitis of jaws, cost is low in order to overcome above-mentioned existing technical deficiency, treatment osteomyelitis of jaws curative effect is high, have no side effect, there is heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, dredging the meridian, benefiting vital QI and blood, hard masses softening and resolving, detumescence and apocenosis, putrefaction-removing granulation-promoting, eliminating stasis to stop pain effect.To suppurative osteomyelitis, central, marginal osteomyelitis acute stage, chronic phase, topical type or diffusion-type etc. all have specially good effect.
The technical scheme that the present invention solves the problems of the technologies described above employing is: a kind of Chinese medicine composition for osteomyelitis of jaws, it is characterized in that, raw material composition is by weight percentage: Rabdosia rubescens 9 ~ 12%, Cortex Lycii 4 ~ 7%, Rhizoma Drynariae 3 ~ 6%, Herba speranskiae tuberculatae 4 ~ 6%, Herba Polygalae Japonicae 5 ~ 8%, Spina Gleditsiae 2 ~ 5%, Cortex Dictamni 2 ~ 4%, the Radix Angelicae Dahuricae 2 ~ 4%, Pseudobulbus Bletillae (Rhizoma Bletillae) 4 ~ 6%, Cortex Acanthopancis 2 ~ 4%, Galla Chinensis 2 ~ 3%, Halloysitum Rubrum 4 ~ 6%, Radix Trichosanthis 4 ~ 6%, Radix Arnebiae (Radix Lithospermi) 3 ~ 5%, Herba Asari 1 ~ 2%, Rhizoma Polygoni Cuspidati 3 ~ 6%, Herba Orostachyos 2 ~ 5%, Folium Et Cacumen Murrayae 3 ~ 5%, Radix Achyranthis Bidentatae 3 ~ 6%, Semen Momordicae 0.2 ~ 1%, Carapax Trionycis 6 ~ 9%, Pseudobulbus Cremastrae Seu Pleiones 2 ~ 4%, Radix Sophorae Tonkinensis 1 ~ 3%, above-mentioned 23 taste crude drug are soaked in water, to remove slag after decocting to obtain filtrate.
The invention has the beneficial effects as follows, treatment osteomyelitis of jaws is without any side effects, curative effect is high, not easily recur after healing, there is heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, dredging the meridian, benefiting vital QI and blood, hard masses softening and resolving, detumescence and apocenosis, putrefaction-removing granulation-promoting, eliminating stasis to stop pain effect, have specially good effect to pyogenic osteomyelitis of jaws etc.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described:
Embodiment 1:
The present embodiment adopts Rabdosia rubescens, Cortex Lycii, Rhizoma Drynariae, Herba speranskiae tuberculatae, Herba Polygalae Japonicae, Spina Gleditsiae, Cortex Dictamni, the Radix Angelicae Dahuricae, Pseudobulbus Bletillae (Rhizoma Bletillae), Cortex Acanthopancis, Galla Chinensis, Halloysitum Rubrum, Radix Trichosanthis, Radix Arnebiae (Radix Lithospermi), Herba Asari, Rhizoma Polygoni Cuspidati, Herba Orostachyos, Folium Et Cacumen Murrayae, Radix Achyranthis Bidentatae, Semen Momordicae, Carapax Trionycis, Pseudobulbus Cremastrae Seu Pleiones, Radix Sophorae Tonkinensis to be that raw material is prepared from.Its component (% by weight) is often paid as Rabdosia rubescens 11.1, Cortex Lycii 5.6, Rhizoma Drynariae 4.5, Herba speranskiae tuberculatae 4.8, Herba Polygalae Japonicae 6.6, Spina Gleditsiae 3.9, Cortex Dictamni 3.8, the Radix Angelicae Dahuricae 3.7, Pseudobulbus Bletillae (Rhizoma Bletillae) 5.4, Cortex Acanthopancis 3.3, Galla Chinensis 2.2, Halloysitum Rubrum 5.5, Radix Trichosanthis 5.1, Radix Arnebiae (Radix Lithospermi) 3.3, Herba Asari 1.2, Rhizoma Polygoni Cuspidati 5.1, Herba Orostachyos 3.1, Folium Et Cacumen Murrayae 4.2, Radix Achyranthis Bidentatae 4.1, Semen Momordicae 0.3, Carapax Trionycis 7.9, Pseudobulbus Cremastrae Seu Pleiones 3.4, Radix Sophorae Tonkinensis 1.9.Getting above-mentioned 23 raw material gross weights is 281 grams, first Carapax Trionycis, Halloysitum Rubrum list bag is decocted first, and 21 Chinese herbal medicine of remaininging add water 900 ~ 1000ml, soak 2 ~ 3 hours.After Carapax Trionycis, Halloysitum Rubrum boil 30 minutes, immersion 21 Chinese herbal medicine are descended to pour in container together with immersion water again, boiling slow fire with high heat decocts to 60 ~ 80 minutes, remove slag to obtain filtrate about 200ml, and medicinal residues add water about 300 ~ 400ml again, and remove slag to obtain filtrate about 100ml, be total to about 300ml medicine juice shakes up, i.e. obtained " insulting bone gold angle soup ", load in sterile glass vials, seal bottle cap is for subsequent use.Every day 1 dose point 3 times is oral, each (medicine) being taken before meal about 100ml.
Principal agent Rabdosia rubescens test tube method experiment in vitro of the present invention proves, Rabdosia rubescens ethanol extract has obvious antibacterial action to staphylococcus aureus and alpha streptococcus, stronger antibacterial action is shown to Staphylococcus albus, group B streptococcus, expense Shigella flexneri, also stronger to Bacillus typhi, dysentery bacterium, Streptococcus mutans effect.Its nature and flavor are bitter, sweet, be slightly cold, return lung, stomach, Liver Channel.There is heat-clearing and toxic substances removing, promoting blood circulation and stopping pain effect, for laryngopharynx swelling and pain , mass in the abdomen mass in the abdomen, snake bite and insect sting.Cortex Lycii bacteriostatic experiment: all have stronger bacteriostasis to staphylococcus aureus, Bacillus typhi, paratyphoid bacillus A etc.Nature and flavor are sweet, cold, return lung, liver, kidney channel.There is removing heat from blood except steaming, lung heat clearing pathogenic fire reducing effect, for deficiency of YIN hectic fever, hectic fever due to YIN-deficiency night sweat, cough due to lung-heat, spitting of blood, epistaxis, interior heat loss.Rhizoma Drynariae nature and flavor are bitter, warm, and return liver, kidney channel, have pain relieving of curing the wound, the kidney invigorating bone strengthening effect, frustrate for falling to wink, muscles and bones is sprained, lumbago due to renal deficiency, and muscles and bones flaccidity is soft, Hiccough and deaf, odontoseisis etc.Herba speranskiae tuberculatae nature and flavor acrid, bitter, warm, has loose wind damp eliminating, removing toxic substances analgesic efficacy.For rheumatic arthritis, sore swollen toxin etc. is controlled in external.Herba Polygalae Japonicae nature and flavor are pungent, bitter, flat, return lung meridian.There is expelling phlegm for arresting cough, promoting blood circulation and detumescence, removing toxic substances analgesic efficacy, for cough with copious phlegm, laryngopharynx swelling and pain etc.Spina Gleditsiae nature and flavor are pungent, warm, return liver, stomach warp, have detumescence poison holding, evacuation of pus, disinsection efficiency, for carbuncle from the beginning of or pus do not become routed etc.Cortex Dictamni nature and flavor are bitter, cold, return spleen, stomach, urinary bladder channel.Have heat clearing and damp drying, dispel the wind detoxicating functions.For damp and hot sore, yellow fluid is dripping, eczema, rubella, scabies skin ulcer leprosy, beriberoid pyretic arthralgia, jaundice dark coloured urine.Radix Angelicae Dahuricae nature and flavor are pungent, warm, return stomach, large intestine, lung meridian, have the cold expelling that induces sweat, wind-expelling pain-stopping, a surname's clearing the nasal passage, dampness leukorrhagia stopping, detumescence and apocenosis effect.For headache due to common cold, supraorbital bone pain, nasal obstruction watery nasal discharge, allergic rhinitis, nasal sinusitis, toothache, leukorrhagia, skin infection swells and ache.Pseudobulbus Bletillae (Rhizoma Bletillae) nature and flavor are bitter, sweet, puckery, be slightly cold, and return lung, liver, stomach warp, have astringing to arrest bleeding, detumescence and promoting granulation effect.For spitting of blood, haematemesis, traumatic hemorrhage, sore swollen toxin, chapped skin.Cortex Acanthopancis nature and flavor acrid, bitter, warm, returns Liver and kidney warp, has expelling wind and removing dampness, liver and kidney tonifying, bone and muscle strengthening, inducing diuresis to remove edema effect, and for rheumatic arthralgia, muscles and bones flaccidity is soft, and body void is weak, edema etc.Galla Chinensis nature and flavor are sour, puckery, cold, return lung, large intestine, kidney channel.There is pathogenic fire reducing of astringing the lung, relieving diarrhea with astringents, arresting sweating, hemostasis, removing dampness sore effect.For chronic cough of deficiency lung, lung-heat phlegmatic cough, chronic diarrhea chronic dysentery, spontaneous sweating, quenches one's thirst, hemorrhoidal bleeding of having blood in stool, traumatic hemorrhage, carbuncle sore tumefacting virus, Skin wet and rotten.Halloysitum Rubrum nature and flavor are sweet, sour, puckery, warm, return large intestine, stomach warp.There is astringing intestine to stop diarrhea, hemostasis, promoting tissue regeneration and ulcer healing effect.For chronic diarrhea chronic dysentery, fecal blood, bleeding not during menses, skin infection is burst for a long time and is not held back, eczema pus contamination etc.Sweet, the micro-hardship of Radix Trichosanthis nature and flavor, to be slightly cold, to attach to the lung and stomach meridians.There is heat clearing away removing water retention by purgation, promoting the production of body fluid to quench thirst, detumescence and apocenosis effect.For calentura excessive thirst, lung-heat type cough, interior-heat is quenched one's thirst, sore swollen toxin.Radix Arnebiae (Radix Lithospermi) nature and flavor are sweet, salty, cold, GUIXIN, Liver Channel.There is clearing away heat and cooling blood, promoting blood circulation and detoxication, rash speckle removing effect.Contain for heat in blood poison, macule purple is black, measles without adequate eruption, skin infection, eczema, and water is long scalds.Herba Asari nature and flavor are pungent, warm, GUIXIN, lung, kidney channel.There is expelling wind and cold, wind-expelling pain-stopping, sensible, warming the lung to resolve fluid-retention effect.For anemofrigid cold, headache, toothache, rheumatic arthralgia etc.Rhizoma Polygoni Cuspidati mildly bitter flavor, to be slightly cold, to return liver, gallbladder, lung meridian.There is dampness removing jaundice eliminating, heat-clearing and toxic substances removing, eliminating stasis to stop pain, relieving cough and resolving phlegm effect.For jaundice due to damp-heat, stranguria with turbid discharge, leukorrhagia, rheumatic arthralgia, carbuncle sore tumefacting virus etc.Herba Orostachyos nature and flavor are sour, bitter, cool, return liver, lung, spleen channel.There is removing heat from blood, hemostasis, removing toxic substances, sore effect.For dysentery, have blood in stool, hemorrhoidal bleeding, open sore part disunion of a specified duration.Pungent, the micro-hardship of Folium Et Cacumen Murrayae nature and flavor, temperature, slightly poisonous, return liver, stomach warp.There are promoting the circulation of QI to relieve pain, promoting blood circulation to remove blood stasis effect.For stomachache, rheumatic arthralgia, toothache, tumbling and swelling etc.Radix Achyranthis Bidentatae nature and flavor are bitter, sweet, sour, flat, return liver, kidney channel.There is eliminating blood stasis and inducing menstruation, invigorating the liver and kidney, bone and muscle strengthening, inducing diuresis for treating stranguria syndrome, conducting blood to flow downwards effect.For amenorrhea, dysmenorrhea, soreness of waist and knee joint, muscles and bones is unable, edema, headache, toothache, aphtha etc.Semen Momordicae nature and flavor are bitter, micro-sweet, cool, poisonous, return liver, spleen, stomach warp.Have mass dissipating and swelling eliminating, counteracting toxic substances treats skin ulcer effect.For sore swollen toxin, acute mastitis, scrofula etc.Carapax Trionycis nature and flavor are salty, be slightly cold, and return liver, kidney channel.There is nourishing YIN for suppressing the hyperactive YANG, bringing down a fever except steaming, hard masses softening and resolving effect.For fever due to yin deficiency, hectic fever due to YIN-deficiency consumptive fever, hyperactivity of YANG due to deficiency of YIN, has a dizzy spell, stirring-up of pathogenic wind in the interior resulting from deficiency, clonic convulsion of the hand and foot, amenorrhea , WEIJIA etc.Pseudobulbus Cremastrae Seu Pleiones nature and flavor are sweet, micro-pungent, cool, return liver, spleen, have heat-clearing and toxic substances removing, dissipating phlegm and resolving masses effect.For carbuncle sore tumefacting virus, scrofula productive cough, snake bite and insect sting , WEIJIA mass in the abdomen.Radix Sophorae Tonkinensis nature and flavor are bitter, cold, poisonous, attach to the lung and stomach meridians, have heat-clearing and toxic substances removing, detumescence sore-throat relieving effect.Pent up for long poison, tonsillitis sore throat, laryngopharynx swelling and pain, gingivitis, aphtha of the mouth and tongue.23 ingenious prescriptions of Chinese herbal medicine, scientific compatibility, mutual reinforcement between mutual-assistance compatibility, can play synergism, can improve drug effect; Mutual restraint between two drugs, mutual-detoxication compatibility, can alleviate or eliminate poisonous side effect of medicine.Oral medicine soup coordinates mass soak, can accelerate to remove affected part sepage, eliminates swelling, alleviates infection, promotes that slough is discharged.The mutual coordinative role of medicine, plays the specially good effect for the treatment of osteomyelitis of jaws altogether.
The each crude drug of the present invention also can the embodiment that mixes of ratio (percentage by weight) listed by according to the form below realize.Its processing technique is identical with embodiment 1.
Medicine name Embodiment 2 Embodiment 3 Embodiment 4
Rabdosia rubescens 11.1 10.9 10.7
Cortex Lycii 5.6 6.1 5.3
Rhizoma Drynariae 4.5 5.1 4.3
Herba speranskiae tuberculatae 4.8 5.1 4.3
Herba Polygalae Japonicae 6.6 7.4 7.1
Spina Gleditsiae 3.9 4.1 3.6
Cortex Dictamni 3.8 3.3 3.6
The Radix Angelicae Dahuricae 3.7 3.1 3.6
Pseudobulbus Bletillae (Rhizoma Bletillae) 5.4 5.6 5.2
Cortex Acanthopancis 3.3 3.9 3.6
Galla Chinensis 2.2 2.3 2.1
Halloysitum Rubrum 5.5 5.2 5.3
Radix Trichosanthis 5.1 4.9 5.3
Radix Arnebiae (Radix Lithospermi) 3.3 3.5 3.6
Herba Asari 1.2 1.4 1.1
Rhizoma Polygoni Cuspidati 5.1 4.5 5.3
Herba Orostachyos 3.1 3.3 3.2
Folium Et Cacumen Murrayae 4.2 3.9 4.3
Radix Achyranthis Bidentatae 4.1 3.8 4.3
Semen Momordicae 0.3 0.2 0.4
Carapax Trionycis 7.9 7.1 8.5
Pseudobulbus Cremastrae Seu Pleiones 3.4 3.5 3.2
Radix Sophorae Tonkinensis 1.9 1.8 2.1
Below in conjunction with my institute, the clinical trial that namely In Shandong Weihai central hospital carries out is described in further detail the present invention:
1. clinical case: selected case be in June, 2012 to 2015 a year JIUYUE carry out my institute's department of stomatology diagnosis and treatment, according to clinical manifestation and toposcopy, in conjunction with medical history, osteomyelitis of jaws 64 example coordinating X-ray film to make a definite diagnosis, man 39 example, female 25 example, age 21-65 year, average 37 years old, the course of disease 1 month to 3 years, average 1 year 2 months, upper jaw bone 19 example, mandibular bone 45 example.
2. diagnostic criteria; The traditional Chinese medical science is called " osteomyelitis of the maxillary bone " or " wearing the cheek ", and " disease of tcm Standardization of diagnosis and curative effect " that its diagnostic criteria is promulgated with reference to State Administration of Traditional Chinese Medicine is formulated.
3. Therapeutic Method: oral " insult bone gold angle soup " every day 1 dose point 3 times is oral, and each (medicine) being taken before meal about 100ml, oral " insulting bone gold angle soup " is a course for the treatment of in 10 days, interval 2 days, then applies next course for the treatment of, generally applies 3 courses for the treatment of.
4. therapeutic evaluation
Cure: Ipsilateral Maxillary region pain and toothache disappear, and Maxillary region swelling is disappeared, and body temperature is normal, and limitation of mouth opening is removed, x-ray film making recovers normal.
Take a turn for the better: Ipsilateral Maxillary region pain and toothache obviously alleviate, and Maxillary region swelling is obviously gone down, and occasionally have low grade fever, x-ray film making is even inflammatory infiltration lump.
Invalid: Clinical symptom and sign and x-ray film making are without significant change.
Cure to add and transfer total effective rate to.
5. therapeutic effect: use the routine osteomyelitis of jaws patient of the present invention 64, apply 3 courses for the treatment of, carries out effect assessment according to the standard of curative effect evaluation: cure 49 examples, account for 76.6%; Take a turn for the better 12 examples, accounts for 18.8%; Invalid 3 examples, account for 4.6%.Total effective rate is 95.4%.

Claims (1)

1. the Chinese medicine composition for osteomyelitis of jaws, it is characterized in that, raw material composition is by weight percentage: Rabdosia rubescens 9 ~ 12%, Cortex Lycii 4 ~ 7%, Rhizoma Drynariae 3 ~ 6%, Herba speranskiae tuberculatae 4 ~ 6%, Herba Polygalae Japonicae 5 ~ 8%, Spina Gleditsiae 2 ~ 5%, Cortex Dictamni 2 ~ 4%, the Radix Angelicae Dahuricae 2 ~ 4%, Pseudobulbus Bletillae (Rhizoma Bletillae) 4 ~ 6%, Cortex Acanthopancis 2 ~ 4%, Galla Chinensis 2 ~ 3%, Halloysitum Rubrum 4 ~ 6%, Radix Trichosanthis 4 ~ 6%, Radix Arnebiae (Radix Lithospermi) 3 ~ 5%, Herba Asari 1 ~ 2%, Rhizoma Polygoni Cuspidati 3 ~ 6%, Herba Orostachyos 2 ~ 5%, Folium Et Cacumen Murrayae 3 ~ 5%, Radix Achyranthis Bidentatae 3 ~ 6%, Semen Momordicae 0.2 ~ 1%, Carapax Trionycis 6 ~ 9%, Pseudobulbus Cremastrae Seu Pleiones 2 ~ 4%, Radix Sophorae Tonkinensis 1 ~ 3%, above-mentioned 23 taste crude drug are soaked in water, to remove slag after decocting to obtain filtrate.
CN201510783714.9A 2015-11-04 2015-11-04 Chinese medicine composition for mandibular osteomyelitis Expired - Fee Related CN105267678B (en)

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* Cited by examiner, † Cited by third party
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CN105998344A (en) * 2016-07-08 2016-10-12 翁敏芬 Traditional Chinese medicine for treating qi-deficiency-toxin-stagnation-syndrome-type maxillary bone osteomyelitis disease

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