CN105169357A - Traditional Chinese medicine for treating chronic gastritis - Google Patents

Abstract

Traditional Chinese medicine for treating the chronic gastritis is prepared from, by weight, 10-30 parts of bupleurum, 8-15 parts of coptidis rhizoma, 8-19 parts of chrysanthemum, 5-15 parts of rhizoma zingiberis, 6-13 parts of radix glycyrrhizae, 10-30 parts of jujube, 5-15 parts of hawthorn, 8-17 parts of black bean peel, 9-16 parts of cooked notoginseng, 5-14 parts of saffron crocus, 7-15 parts of mint, 5-15 parts of roses and 6-19 parts of boat-fruited scaphium seed. The traditional Chinese medicine is scientific in compatibility, simple in component and low in cost and has a remarkable clinical effect on the chronic gastritis, and materials are taken conveniently. Through scientific clinical test observation, the traditional Chinese medicine has the cure rate of 90% or higher and the bounce rate of 2% or lower when treating the chronic gastritis; a capsule is simple in preparation process and suitable for industrial large-scale production.

Description

A kind of Chinese medicine for the treatment of chronic gastritis

Technical field

The present invention relates to tcm field, be specifically related to a kind of Chinese medicine for the treatment of chronic gastritis.

Background technology

Gastritis is the general designation of stomach lining inflammation.Commonly encountered diseases can be divided into acute and chronic two classes, and what acute gastritis was common is pure and erosive two kinds.Chronic gastritis can be divided into superficial gastritis, atrophic gastritis and hypertrophic gastritis again usually.The chronic gastritis course of disease is delayed, most non-evident sympton and sign, generally the indigestion symptom such as rarely seen glutted, pantothenic acid, belch, irregularities stomachache after meal.Primary disease is common in adult, and many causes of disease can stimulate stomach, and as improper diet, virus and bacteriological infection, medicine irritation etc. all may cause primary disease.

The medicine of current treatment gastritis has a lot, such as protects the conventional medicine of gastric mucosa medicine to have colloidal bismuth subcitrate (CBS), sucralfate, Marzulene-S, gel aluminum hydroxide, gastric Mucin etc.; Adjustment gastrointestinal motility function medicament Abdeminal pain domperidone etc.Have the hiccups, abdominal distention or have reflux phenomenon to be main person, available medicine for stomach dynamic; If antibiotic gastroscopy finds Helicobacter pylori, should antibiotic be taken, clarithromycin, amoxicillin etc., have and remove the effect of Hp, generally can select two kinds, normal and gastric mucosa protective agent and acid inhibitor use in conjunction; The medicine that antacid is conventional has sodium bicarbonate, magnesium hydroxide, gel aluminum hydroxide etc.; Analgesic Upper abdominal pain is good to eat compared with severe one takes atropine, probanthine, Semen daturae tablet, to reduce gastric acid secretion and to alleviate colic symptoms; Other symptomatic treatment medicines can use digestant, as pancreatin, yeast tablet, lactasinum, simethicone sheet etc.Also can with acid suppression medicine as cimetidine, ranitidine, famotidine etc. if any acid regurgitation phenomenon.Prevent bile reflux from can take hydrotalcite, cholestyramine to adsorb gallbladder juice; Have the hematemesis person of having blood in stool, cimetidine is oral.

The course for the treatment of of routine clinical treatment gastritis is longer, takes effect fast, but drug side effect is large, and the frequent recurrent exerbation of disease, has had a strong impact on the life health of people.

Summary of the invention

For the defect of prior art, the present invention be directed to the present situation for the treatment of gastritis at present, provide a kind of and need not take the Chinese medicine composition that Western medicine just can reach therapeutic effect, and have no side effect, short treating period, effective.Specifically, the present invention realizes like this.

Inventor provides a kind of prescriptions of Chinese medicine for the treatment of chronic gastritis according to drug matching experience, each raw material dosage of prescription all has good curative effect in weight portion scope of the present invention, and described formula and weight portion are: Radix Bupleuri 10-30 part, Rhizoma Coptidis 8-15 part, Flos Chrysanthemi 8-19 part, Rhizoma Zingiberis 5-15 part, Radix Glycyrrhizae 6-13 part, Fructus Jujubae 10-30 part, Fructus Crataegi 5-15 part, Testa sojae atricolor 8-17 part, cooked Radix Notoginseng 9-16 part, Stigma Croci 5-14 part, Herba Menthae 7-15 part, Flos Rosae Rugosae 5-15 part, Semen Sterculiae Lychnophorae 6-19 part.

In order to play good effect further, described formula and weight portion are: Radix Bupleuri 10-20 part, Rhizoma Coptidis 8-10 part, Flos Chrysanthemi 15-19 part, Rhizoma Zingiberis 9-13 part, Radix Glycyrrhizae 8-10 part, Fructus Jujubae 15-25 part, Fructus Crataegi 8-12 part, Testa sojae atricolor 10-13 part, cooked Radix Notoginseng 11-14 part, Stigma Croci 8-12 part, Herba Menthae 10-12 part, Flos Rosae Rugosae 10-15 part, Semen Sterculiae Lychnophorae 6-12 part.

Reach optimum effect, to described formula and weight portion be: Radix Bupleuri 15 parts, Rhizoma Coptidis 9 parts, Flos Chrysanthemi 11 parts, Rhizoma Zingiberis 11 parts, 9 parts, Radix Glycyrrhizae, 20 parts, Fructus Jujubae, Fructus Crataegi 10 parts, Testa sojae atricolor 11 parts, cooked Radix Notoginseng 12 parts, Stigma Croci 10 parts, Herba Menthae 11 parts, Flos Rosae Rugosae 13 parts, Semen Sterculiae Lychnophorae 6 parts.

The function of each taste Chinese crude drug used in the Chinese medicine composition for the treatment of chronic gastritis of the present invention is as follows:

Radix Bupleuri: bitter in the mouth, is slightly cold.

Gui Jing: return liver, gallbladder meridian.

Function cures mainly: reconciling superficies and interior, soothing the liver, yang invigorating, for cold, fever, and alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, sub-official's prolapsus, proctoptosis.

Flos Chrysanthemi: sweet in the mouth, is slightly cold.

Gui Jing: return lung, Liver Channel.

Function cures mainly: loose wind heat clearing away, suppressing the hyperactive liver improving eyesight, for anemopyretic cold, have a headache dizzy, conjunctival congestion and swelling pain, eyes is dim-sighted.

Cooked Radix Notoginseng: sweet in the mouth, warm in nature.

Gui Jing: return liver, stomach warp.

Function cures mainly: dissipating blood stasis stops blooding, and subduing swelling and relieving pain, for haematemesis of spitting blood, epistaxis is had blood in stool, metrorrhagia, traumatic hemorrhage, and breast abdomen twinges, tumbling and swelling.

Herba Menthae: acrid in the mouth, cool in nature.

Gui Jing: return lung, Liver Channel.

Function cures mainly: dispelling wind-heat.Refresh oneself, rash, for anemopyretic cold, pathogenic wind-warm from the beginning of, headache, conjunctival congestion, sore throat, aphtha, rubella measles, breast the side of body feeling of distension and oppression.

Rhizoma Coptidis: bitter in the mouth, cold in nature.

Gui Jing: GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.

Function cures mainly: heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood tells nosebleed, conjunctival congestion, and toothache, quenches one's thirst, carbuncle furuncle; External treatment eczema, eczema, auditory meatus is suppurated.Rhizoma Coptidis (processed with wine) is apt to the clear part of the body cavity above the diaphragm housing the heart and lungs intimately, for conjunctival congestion, and aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach stomach function regulating preventing or arresting vomiting.Tie mutually for cold and heat, damp and hot middle resistance, feeling of fullness is vomitted.Cornel Rhizoma Coptidis soothing liver-QI stomach function regulating preventing or arresting vomiting.For incoordination between the liver and stomach, vomiting acid regurgitation.

Flos Rosae Rugosae: sweet in the mouth, warm in nature.

Gui Jing: return liver, spleen channel.

Function cures mainly: promoting QI circulation for relieving depression, regulating blood flow to alleviate pains, and for stomachache due to hyperactive liver-QI attacking the stomach, lack of appetite vomiting and nausea, menoxenia, falls and flutter the pain of injury.

Semen Sterculiae Lychnophorae: sweet in the mouth, cold in nature.

Gui Jing: return lung, large intestine channel.

Function cures mainly: clearing heat and moistening lung, liyan jiedu, loosening bowel to relieve constipation, and for lung-heat celostomia, dry cough without phlegm, pharyngodynia with dryness, accumulation of heat just closes, headache conjunctival congestion.

Rhizoma Zingiberis: acrid in the mouth, hot in nature.

Gui Jing: return spleen, stomach, kidney, the heart, lung meridian.

Function cures mainly: warming spleen and stomach for dispelling cold, and recuperating depleted YANG is promoted blood circulation, warming the lung to resolve fluid-retention, appetite stimulator.

Stigma Croci: sweet in the mouth, property is put down.

Gui Jing: enter the heart, Liver Channel.

Function cures mainly: blood circulation promoting and blood stasis dispelling stimulates the menstrual flow, removing pathogenic heat from blood and toxic substance from the body, and for amenorrhea and mass in the abdomen, postpartum stagnation, maculae caused by violent heat pathogen, melancholy painful abdominal mass is vexed, and palpitation with fear is gone mad.

Radix Glycyrrhizae: sweet in the mouth, property is put down.

Gui Jing: GUIXIN, lung, spleen, stomach warp.

Function cures mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, for weakness of the spleen and stomach, and fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm.

Fructus Jujubae: sweet in the mouth, warm in nature.

Gui Jing: return spleen, stomach warp.

Function cures mainly: invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind, and for insufficiency of the spleen lack of appetite, weak loose stool, woman hysteria, circulation of qi promoting, menoxenia, redly collapses, leucorrhea.

Fructus Crataegi: sweet in the mouth, warm in nature.

Gui Jing: return spleen, stomach warp.

Function cures mainly: invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind, relaxes the property of medicine, and for insufficiency of the spleen few loose stool, fatigue and weakness, blood deficiency and yellow complexion and women's internal organs, mind is uneasy, protection healthy energy.

Testa sojae atricolor: sweet in the mouth, cool in nature.

Gui Jing: return spleen, lung, kidney channel.

Function cures mainly: the suppressing the hyperactive liver that nourishes blood, removing toxic substances of dispeling the wind, cure mainly headache, deficiency of YIN dysphoria with smothery sensation, night sweat, migratory arthralgia, noxious dampness, carbuncle skin ulcer, dizzy etc.

According to theory of Chinese medical science, gastritis is divided into chronic gastritis and acute gastritis, chronic gastritis should based on conditioning, in above-mentioned all medicines, in side of the present invention with Flos Chrysanthemi, Rhizoma Coptidis for monarch drug, the property of its bitter cold, can clearing stomach fire, its property is sweet again, again can nourishing stomach-YIN, especially plays primary treatment effect to property gastritis; Radix Bupleuri, Testa sojae atricolor, Herba Menthae, Radix Glycyrrhizae are ministerial drug, and play depressed liver-energy dispersing and QI regulating, nourish blood suppressing the hyperactive liver, promoting QI circulation for relieving depression, effect of regulating blood flow to alleviate pains; With Fructus Jujubae, Fructus Crataegi, cooked Radix Notoginseng, Stigma Croci, Flos Rosae Rugosae, Semen Sterculiae Lychnophorae for adjuvant drug, invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, relaxes the property of medicine, eliminates food stagnation, and middle clearing stomach, nourishes stomach further; Rhizoma Zingiberis, for making medicine, is coordinating the actions of various ingredients in a prescription drug effect, corrects prescription flavour, compatibility science, and composition is simple, and draw materials conveniently, cost is low, and clinical have curative effect significantly to chronic gastritis.

The present invention's second object is to provide a kind of Therapeutic Method for the treatment of gastritis, and concrete steps are:

(1) by Stigma Croci, Flos Rosae Rugosae, Semen Sterculiae Lychnophorae, Flos Chrysanthemi, Radix Bupleuri, Fructus Jujubae, Rhizoma Zingiberis, Testa sojae atricolor roguing, and add 10-13 times amount water soaking 0.5-2 hour, intense fire decocts boiling 15 minutes, then adds Herba Menthae, then uses slow fire boiling 1-5 hour; Filter, filtering residue adds 5-8 times of water gaging, slow fire boiling 1-2 hour after intense fire decocts and seethes with excitement; Filter, merge twice filtrate, it is the dope of 1.15-1.25 that filtrate is concentrated into relative density under 70 DEG C of environment, for subsequent use;

(2) by Rhizoma Coptidis, Fructus Crataegi, cooked Radix Notoginseng, Radix Glycyrrhizae decontamination, clean, dry, grind to form 60-80 order fine powder;

(3) dope that juice above-mentioned steps (1) prepared and step (2) are made merges, and is concentrated into the thick paste that relative density is 1.20-1.35, drying under reduced pressure, crosses 60-80 mesh sieve, obtain uniform fine powder after pulverizing;

(4) fine powder step (3) made in conjunction with mix homogeneously with pharmaceutically acceptable adjuvant, incapsulates, obtains capsule.

Pharmaceutical preparation of the present invention be capsule by weight part ratio be 1: 1-10.0 mixture and pharmaceutically acceptable adjuvant make, be more preferably that the Chinese medicine composition of 1:1.3-5.8 and pharmaceutically acceptable adjuvant are made by weight part ratio.

Described pharmaceutically acceptable adjuvant comprises filler and binding agent; Described filler is selected from the mixture of one or two or more kinds in mannitol, lactose, sucrose, cyclodextrin, preferably from lactose; Binding agent is selected from the one in 75% alcoholic solution of 3%PVP, 50% alcoholic solution of 3% hypromellose, the aqueous solution of 10% PVP K30,30% starch slurry, is preferably 50% alcoholic solution of 3% hypromellose.

Described Chinese medicine composition can be used for treating the Chinese medicine composition of chronic gastritis, is particluarly suitable for the application for the treatment of superficial gastritis.

Compared with prior art, the Chinese medicine preparation for the treatment of chronic gastritis of the present invention compared with prior art has outstanding beneficial effect, be mainly manifested in, the pure Chinese herb that the present invention uses, monarch, make up a prescription complete, to hit case, effective treatment chronic gastritis, easy and simple to handle, industrialized production can be carried out, it is high that the therapeutic effect of medicine of the present invention has curative effect, instant effect, the features such as short treating period, and expense is low, safety non-toxic side reaction, there is higher social value, find through clinical trial, the effective percentage of Drug therapy of the present invention is more than 99%.

Specific embodiment

Embodiment 1:

Radix Bupleuri 10 grams, Rhizoma Coptidis 8 grams, Flos Chrysanthemi 8-gram, Rhizoma Zingiberis 5 grams, 6 grams, Radix Glycyrrhizae, 10 grams, Fructus Jujubae, Fructus Crataegi 5-gram, Testa sojae atricolor 8-gram, cooked Radix Notoginseng 9 grams, Stigma Croci 5-gram, Herba Menthae 7 grams, Flos Rosae Rugosae 5 grams, Semen Sterculiae Lychnophorae 6 grams.

Preparation technology:

(1) by Stigma Croci, Flos Rosae Rugosae, Semen Sterculiae Lychnophorae, Flos Chrysanthemi, Radix Bupleuri, Fructus Jujubae, Rhizoma Zingiberis, Testa sojae atricolor roguing, and add 10-13 times amount water soaking 0.5-2 hour, intense fire decocts boiling 15 minutes, then adds Herba Menthae, then uses slow fire boiling 1-5 hour; Filter, filtering residue adds 5-8 times of water gaging, slow fire boiling 1-2 hour after intense fire decocts and seethes with excitement; Filter, merge twice filtrate, it is the dope of 1.15-1.25 that filtrate is concentrated into relative density under 70 DEG C of environment, for subsequent use;

(2) by Rhizoma Coptidis, Fructus Crataegi, cooked Radix Notoginseng, Radix Glycyrrhizae decontamination, clean, dry, grind to form 60-80 order fine powder;

(3) dope that juice above-mentioned steps (1) prepared and step (2) are made merges, and is concentrated into the thick paste that relative density is 1.20-1.35, drying under reduced pressure, crosses 60-80 mesh sieve, obtain uniform fine powder after pulverizing;

(4) fine powder step (3) made, then to be granulated with 50% alcoholic solution of 3% appropriate hypromellose in conjunction with mix homogeneously with lactose, incapsulates, obtain capsule after drying.

Embodiment 2:

Radix Bupleuri 30 grams, Rhizoma Coptidis 15 grams, Flos Chrysanthemi 19 grams, Rhizoma Zingiberis 15 grams, 13 grams, Radix Glycyrrhizae, 30 grams, Fructus Jujubae, Fructus Crataegi 15 grams, Testa sojae atricolor 17 grams, cooked Radix Notoginseng 16 grams, Stigma Croci 14 grams, Herba Menthae 15 grams, Flos Rosae Rugosae 15 grams, Semen Sterculiae Lychnophorae 19 grams.

Preparation technology:

(1) by Stigma Croci, Flos Rosae Rugosae, Semen Sterculiae Lychnophorae, Flos Chrysanthemi, Radix Bupleuri, Fructus Jujubae, Rhizoma Zingiberis, Testa sojae atricolor roguing, and add 10-13 times amount water soaking 0.5-2 hour, intense fire decocts boiling 15 minutes, then adds Herba Menthae, then uses slow fire boiling 1-5 hour; Filter, filtering residue adds 5-8 times of water gaging, slow fire boiling 1-2 hour after intense fire decocts and seethes with excitement; Filter, merge twice filtrate, it is the dope of 1.15-1.25 that filtrate is concentrated into relative density under 70 DEG C of environment, for subsequent use;

(2) by Rhizoma Coptidis, Fructus Crataegi, cooked Radix Notoginseng, Radix Glycyrrhizae decontamination, clean, dry, grind to form 60-80 order fine powder;

(3) dope that juice above-mentioned steps (1) prepared and step (2) are made merges, and is concentrated into the thick paste that relative density is 1.20-1.35, drying under reduced pressure, crosses 60-80 mesh sieve, obtain uniform fine powder after pulverizing;

(4) fine powder step (3) made, then to be granulated with 50% alcoholic solution of 3% appropriate hypromellose in conjunction with mix homogeneously with lactose, incapsulates, obtain capsule after drying.

Embodiment 3:

Radix Bupleuri 10 grams, Rhizoma Coptidis 8 grams, Flos Chrysanthemi 15 grams, Rhizoma Zingiberis 9 grams, 8 grams, Radix Glycyrrhizae, 15 grams, Fructus Jujubae, Fructus Crataegi 8 grams, Testa sojae atricolor 10 grams, cooked Radix Notoginseng 11 grams, Stigma Croci 8 grams, Herba Menthae 10 grams, Flos Rosae Rugosae 10 grams, Semen Sterculiae Lychnophorae 6 grams.

Preparation technology:

(1) by Stigma Croci, Flos Rosae Rugosae, Semen Sterculiae Lychnophorae, Flos Chrysanthemi, Radix Bupleuri, Fructus Jujubae, Rhizoma Zingiberis, Testa sojae atricolor roguing, and add 10-13 times amount water soaking 0.5-2 hour, intense fire decocts boiling 15 minutes, then adds Herba Menthae, then uses slow fire boiling 1-5 hour; Filter, filtering residue adds 5-8 times of water gaging, slow fire boiling 1-2 hour after intense fire decocts and seethes with excitement; Filter, merge twice filtrate, it is the dope of 1.15-1.25 that filtrate is concentrated into relative density under 70 DEG C of environment, for subsequent use;

(2) by Rhizoma Coptidis, Fructus Crataegi, cooked Radix Notoginseng, Radix Glycyrrhizae decontamination, clean, dry, grind to form 60-80 order fine powder;

(3) dope that juice above-mentioned steps (1) prepared and step (2) are made merges, and is concentrated into the thick paste that relative density is 1.20-1.35, drying under reduced pressure, crosses 60-80 mesh sieve, obtain uniform fine powder after pulverizing;

(4) fine powder step (3) made, then to be granulated with 50% alcoholic solution of 3% appropriate hypromellose in conjunction with mix homogeneously with lactose, incapsulates, obtain capsule after drying.

Embodiment 4:

Radix Bupleuri 20 grams, Rhizoma Coptidis 10 grams, Flos Chrysanthemi 19 grams, Rhizoma Zingiberis 13 grams, 10 grams, Radix Glycyrrhizae, 25 grams, Fructus Jujubae, Fructus Crataegi 12 grams, Testa sojae atricolor 13 grams, cooked Radix Notoginseng 14 grams, Stigma Croci 12 grams, Herba Menthae 12 grams, Flos Rosae Rugosae 15 grams, Semen Sterculiae Lychnophorae 12 grams.

Preparation technology:

(1) by Stigma Croci, Flos Rosae Rugosae, Semen Sterculiae Lychnophorae, Flos Chrysanthemi, Radix Bupleuri, Fructus Jujubae, Rhizoma Zingiberis, Testa sojae atricolor roguing, and add 10-13 times amount water soaking 0.5-2 hour, intense fire decocts boiling 15 minutes, then adds Herba Menthae, then uses slow fire boiling 1-5 hour; Filter, filtering residue adds 5-8 times of water gaging, slow fire boiling 1-2 hour after intense fire decocts and seethes with excitement; Filter, merge twice filtrate, it is the dope of 1.15-1.25 that filtrate is concentrated into relative density under 70 DEG C of environment, for subsequent use;

(2) by Rhizoma Coptidis, Fructus Crataegi, cooked Radix Notoginseng, Radix Glycyrrhizae decontamination, clean, dry, grind to form 60-80 order fine powder;

(3) dope that juice above-mentioned steps (1) prepared and step (2) are made merges, and is concentrated into the thick paste that relative density is 1.20-1.35, drying under reduced pressure, crosses 60-80 mesh sieve, obtain uniform fine powder after pulverizing;

(4) fine powder step (3) made, then to be granulated with 30% appropriate starch slurry solution in conjunction with mix homogeneously with mannitol, incapsulates, obtain capsule after drying.

Embodiment 5:

Radix Bupleuri 15 grams, Rhizoma Coptidis 9 grams, Flos Chrysanthemi 11 grams, Rhizoma Zingiberis 11 grams, 9 grams, Radix Glycyrrhizae, 20 grams, Fructus Jujubae, Fructus Crataegi 10 grams, Testa sojae atricolor 11 grams, cooked Radix Notoginseng 12 grams, Stigma Croci 10 grams, Herba Menthae 11 grams, Flos Rosae Rugosae 13 grams, Semen Sterculiae Lychnophorae 6 grams.

Preparation technology:

(1) by Stigma Croci, Flos Rosae Rugosae, Semen Sterculiae Lychnophorae, Flos Chrysanthemi, Radix Bupleuri, Fructus Jujubae, Rhizoma Zingiberis, Testa sojae atricolor roguing, and add 10-13 times amount water soaking 0.5-2 hour, intense fire decocts boiling 15 minutes, then adds Herba Menthae, then uses slow fire boiling 1-5 hour; Filter, filtering residue adds 5-8 times of water gaging, slow fire boiling 1-2 hour after intense fire decocts and seethes with excitement; Filter, merge twice filtrate, it is the dope of 1.15-1.25 that filtrate is concentrated into relative density under 70 DEG C of environment, for subsequent use;

(2) by Rhizoma Coptidis, Fructus Crataegi, cooked Radix Notoginseng, Radix Glycyrrhizae decontamination, clean, dry, grind to form 60-80 order fine powder;

(3) dope that juice above-mentioned steps (1) prepared and step (2) are made merges, and is concentrated into the thick paste that relative density is 1.20-1.35, drying under reduced pressure, crosses 60-80 mesh sieve, obtain uniform fine powder after pulverizing;

(4) fine powder step (3) made, then to be granulated with 50% alcoholic solution of 3% appropriate hypromellose in conjunction with mix homogeneously with lactose, incapsulates, obtain capsule after drying.

Embodiment 6: clinical observation:

(1) clinical data

The present inventor, year May in May, 2010 to 2015, carries out clinical observation treatment to 374 routine gastritis sufferers, and the age is in 28-58 year.Wherein male 189 example, women 185 example, is divided into treatment group and observation group by patient, the physical data no significant difference (P > 0.05) of two groups of patients at random.

(2) curative effect determinate standard

Cure: Clinical symptom and sign disappears, recover normal;

Effective: the basic or major part of Clinical symptom and sign disappears;

Effective: clinical symptoms is clearly better;

Bounce-back: Effect of follow-up visit by telephone recurred again in 1 month;

Rebound rate: (Effect of follow-up visit by telephone recurred again in 1 month)/(healing)

Invalid: Clinical symptom and sign is without improvement.

(3) diagnostic criteria

Tcm diagnosis standard: (the diagnosis tentative standard that in November, 1989, CAIM's digestive system disease Professional Committee formulated)

1) liver-stomach disharmony type: mainly want syndrome: 1. epigastric distending pain or pain string two side of body.2. belch is frequent.3. noisy pantothenic acid.Secondary syndrome: the 1. acute Active inflammation of gastric mucosa.2. bile reflux.Picture of the tongue pulse condition: body of the tongue is light red, white and thin fur or thick in vain; Stringy pulse.Pattern of syndrome is determined: 1. possess primary symptom two, tongue pulse condition meets substantially.2. possess primary symptom 1 and time disease 1, tongue pulse condition meets substantially.Possess any 1 person can determine.

2) weakness of the spleen and stomach (comprising deficiency and coldness) type: main syndromes: 1. vague epigastralgia.2. pain relieved by pressing happiness of having a stomachache is warm.3. feeling of distension and oppression feeling of fullness after food.4. appetite stimulator.5. loose stool diarrhoea.6. weak extremity are aching and limp.Secondary syndrome: 1. gastric mucosa is red and white with Bai Weizhu.2. mucus is thin and many.3. gastric acid is on the low side.Picture of the tongue pulse condition: 1. body of the tongue is light red, white and thin fur or white, has indentation.2. deep-thready pulse.Pattern of syndrome is determined: 1. possess main symptom 3, tongue arteries and veins meets substantially.2. possess primary symptom two and time disease 1, tongue arteries and veins meets substantially.Possess any 1 can determine.

3) spleen and stomach damp-heat type: main syndromes: the 1. scorching hot distending pain of gastral cavilty.2. bitter taste halitosis.3. yellowish urine.4. gastral cavity abdomen painful abdominal mass is vexed, thirst but no desire to drink.Secondary syndrome: gastric mucosa is acute, Active inflammation, congested rotten to the corn obviously.Picture of the tongue pulse condition: red tongue, limit point is dark red, and yellow fur is thick or greasy.Rolling pulse, tense pulse.Pattern of syndrome is determined: 1. possess primary symptom two, tongue arteries and veins meets substantially.2. possess primary symptom 1 and secondary disease, tongue arteries and veins meets substantially.Possess any 1 can determine.

4) type of deficiency of stomach yin: main syndromes: the 1. scorching hot pain of gastral cavilty.2. dry mouth and tougue.3. be hard and dry.Secondary syndrome: 1. gastric mucosa lamellar is red and white, and mucosa is thinning.2. gastric mucosa is dry, and mucus is few.3. gastric acid is on the low side.Picture of the tongue pulse condition: 1. red tongue with a little fluid or have crackle.2. thready pulse or stringy and thready pulse.Pattern of syndrome is determined: 1. possess primary symptom two and tongue arteries and veins meets.2. possess primary symptom 1 and secondary disease two, tongue arteries and veins meets substantially.Possess above any 1 can determine.

5) stomach network blood stasis type: main disease: 1. gastral cavilty localized pain, not pain relieved by pressing.2. have a stomach-ache and with the passing of time do not heal.3. ambassador's occult blood positive or black hemafecia.Secondary disease: the congested swelling of gastric mucosa, companion's ecchymosis or petechia.Picture of the tongue pulse condition: 1. dimly red tongue, or purple dark, or have ecchymosis.2. stringy and hesitant pulse.Pattern of syndrome is determined: 1. possess primary symptom two, tongue arteries and veins meets substantially.2. possess primary symptom 1 and add time disease; Tongue arteries and veins meets substantially.Possess above any 1 can determine.

(4) Therapeutic Method

Treatment group: male 94 people, female 95 people; Take capsule prepared by the embodiment of the present invention 5, each 2, every day 3 times, 7 days courses for the treatment of of one after each meal;

Observation group: male 92 people, female 93 people, takes XIANGSHA YANGWEI WAN, clothes time mouth 8 ball, 3 times on the one, 7 days courses for the treatment of of one after each meal

(5) therapeutic effect:

The present invention prepares simply, and good absorbing effect is evident in efficacy, and have no side effect, safety is high, is conducive to patient and alleviates condition of illness in time.Detailed results is in table 1.

Table 1 treatment group and observation group's therapeutic effect compare

Over the course for the treatment of tracing observation is carried out for 374 routine patients, does not find obvious untoward reaction.

As can be seen from Table 1, after the treatment of 3 courses for the treatment of, treatment by Chinese herbs group of the present invention, cure rate is up to more than 90%, and matched group cure rate is less than 40%.The total effective rate for the treatment of group and matched group is respectively 100% and 92.4%, and rebound rate is respectively 1.7% and 12.4%, visible, and treatment group cure rate and total effective rate are obviously better than matched group.Through statistical procedures, between two groups of patient clinical curative effects, difference has statistical significance (P < 0.05).

Embodiment 7: classical case

Case 1: Liu, man 41 years old, people from Handan, Hebei, there is gastritis medical history for a long time, be about 2-3, superficial gastritis is diagnosed as in the People's Hospital of city, took related drugs afterwards always, poor effect, and often recur, anorexia, health is become thin gradually, in May, 2013, I treated at institute, take the capsule for treating of the embodiment of the present invention 5, after 15 days, taking a turn for the better appears in patient body, dietary amount increases, after continuing to take 30 days, weight in patients increases, through tcm diagnosis, physical recovery is normal, after 1 year, call-on back by phone does not recur, life is filled with unbounded confidence.

Claims (9)

1. treat the Chinese medicine of chronic gastritis for one kind, it is characterized in that, be made up of the crude drug of following weight portion: Radix Bupleuri 10-30 part, Rhizoma Coptidis 8-15 part, Flos Chrysanthemi 8-19 part, Rhizoma Zingiberis 5-15 part, Radix Glycyrrhizae 6-13 part, Fructus Jujubae 10-30 part, Fructus Crataegi 5-15 part, Testa sojae atricolor 8-17 part, cooked Radix Notoginseng 9-16 part, Stigma Croci 5-14 part, Herba Menthae 7-15 part, Flos Rosae Rugosae 5-15 part, Semen Sterculiae Lychnophorae 6-19 part.

2. Chinese medicine according to claim 1, it is characterized in that, be made up of the crude drug of following weight portion: Radix Bupleuri 10-20 part, Rhizoma Coptidis 8-10 part, Flos Chrysanthemi 15-19 part, Rhizoma Zingiberis 9-13 part, Radix Glycyrrhizae 8-10 part, Fructus Jujubae 15-25 part, Fructus Crataegi 8-12 part, Testa sojae atricolor 10-13 part, cooked Radix Notoginseng 11-14 part, Stigma Croci 8-12 part, Herba Menthae 10-12 part, Flos Rosae Rugosae 10-15 part, Semen Sterculiae Lychnophorae 6-12 part.

3. Chinese medicine according to claim 1, it is characterized in that, be made up of the crude drug of following weight portion: Radix Bupleuri 15 parts, Rhizoma Coptidis 9 parts, Flos Chrysanthemi 11 parts, Rhizoma Zingiberis 11 parts, 9 parts, Radix Glycyrrhizae, 20 parts, Fructus Jujubae, Fructus Crataegi 10 parts, Testa sojae atricolor 11 parts, cooked Radix Notoginseng 12 parts, Stigma Croci 10 parts, Herba Menthae 11 parts, Flos Rosae Rugosae 13 parts, Semen Sterculiae Lychnophorae 6 parts.

4. prepare a preparation method for the Chinese medicine described in any one of claim 1-3, it is characterized in that, concrete step is:

(1) by Stigma Croci, Flos Rosae Rugosae, Semen Sterculiae Lychnophorae, Flos Chrysanthemi, Radix Bupleuri, Fructus Jujubae, Rhizoma Zingiberis, Testa sojae atricolor roguing, and add 10-13 times amount water soaking 0.5-2 hour, intense fire decocts boiling 15 minutes, then adds Herba Menthae, then uses slow fire boiling 1-5 hour; Filter, filtering residue adds 5-8 times of water gaging, slow fire boiling 1-2 hour after intense fire decocts and seethes with excitement; Filter, merge twice filtrate, it is the dope of 1.15-1.25 that filtrate is concentrated into relative density under 70 DEG C of environment, for subsequent use;

(2) by Rhizoma Coptidis, Fructus Crataegi, cooked Radix Notoginseng, Radix Glycyrrhizae decontamination, clean, dry, grind to form 60-80 order fine powder;

(3) dope that juice step (1) prepared and step (2) are made merges, and is concentrated into the thick paste that relative density is 1.20-1.35, drying under reduced pressure, crosses 60-80 mesh sieve, obtain uniform fine powder after pulverizing;

(4) fine powder step (3) made in conjunction with mix homogeneously with pharmaceutically acceptable adjuvant, incapsulates, obtains capsule.

5. the preparation method of Chinese medicine according to claim 4, is characterized in that: described capsule by weight part ratio be 1: 1.0-10.0 mixture and pharmaceutically acceptable adjuvant make.

6. the preparation method of Chinese medicine according to claim 5, is characterized in that: described capsule by weight part ratio be 1: 1.3-5.8 mixture and pharmaceutically acceptable adjuvant make.

7. the preparation method of Chinese medicine according to claim 4, is characterized in that: described pharmaceutically acceptable adjuvant comprises filler, binding agent; Wherein: described filler is selected from the mixture of one or two or more kinds in mannitol, lactose, sucrose, cyclodextrin; Described binding agent is selected from the one in 75% alcoholic solution of 3%PVP, 50% alcoholic solution of 3% hypromellose, the aqueous solution of 10% PVP K30,30% starch slurry.

8. the preparation method of Chinese medicine according to claim 7, is characterized in that: described filler is selected from lactose; 50% alcoholic solution that described binding agent is selected from 3% hypromellose collapses.

9. Chinese medicine according to claim 1, is characterized in that: the application of described Chinese medicine in treatment chronic gastritis.