CN103432317A - Medicament for treating headache and preparation method thereof - Google Patents

Abstract

The invention discloses a medicament for treating headache and a preparation method thereof. The medicament is mainly prepared from drugs including notopterygium root, ligusticum wallichii, herba schizeneptae, Chinese parsnip root, wild ginger, radix angelicae formosanae, rhizoma cimicifugae and the like according to certain weight ratios. The medicament has functions of removing wind and dampness and warming the middle-jiao to regulate the flow of qi, and is high in effect taking speed and high in cure rate when used for treating headache.

Description

A kind of medicine for the treatment of headache and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of headache and preparation method thereof, belong to the field of Chinese medicines.

Technical background

Headache is clinical common symptom, usually will be confined to the head first half, comprises the pain general designation headache with upper part of geisoma, helix upper limb and the outer knuckle line of pillow.Headache is because of various, and neuralgia, intracranial infection, intracranial space-occupying lesion, cerebrovascular disease, cranium the outside maxillofacial disease and general disease all can cause headache as actute infection, poisoning etc.Age of onset is common in youth, middle age and old.The cause of disease that causes headache is numerous, is broadly divided into constitutional and Secondary cases two classes.The former can not be owing to a certain definite cause of disease, also can be described as the idiopathic headache, common as migraine, tension-type headache; Latter's cause of disease can relate to various intracranial lesions as cerebrovascular disease, intracranial infection, craniocerebral trauma, and systemic disease is as heating, interior environment disturbance and abuse psychoactive drug etc.At present, because Western medicine can't be had a headache by rapid, effective treatment, and more side effect is arranged, therefore, there is very large demand in people to the Chinese medicine of rapid, effective treatment headache.

Summary of the invention

The inventor, according to the research of theory of Chinese medical science and clinical test and checking repeatedly, has finally found the medicine of effective treatment headache, thereby has completed the present invention.

Purpose of the present invention just is to provide a kind of composition of medicine that can effectively treat headache.

Another object of the present invention just has been to provide the preparation method of this composition of medicine.

Medicine of the present invention selects Rhizoma Et Radix Notopterygii, Rhizoma Chuanxiong, Herba Schizonepetae, Radix Saposhnikoviae, Herba Asari, the Radix Angelicae Dahuricae, Rhizoma Cimicifugae, Rhizoma Ligustici, Herba Menthae, Radix Platycodonis, Radix Bupleuri, Radix Puerariae, Radix Glycyrrhizae, Radix Angelicae Pubescentis, Herba Ephedrae, Radix Scutellariae, Gypsum Fibrosum, Rhizoma Arisaematis, the Rhizoma Pinelliae, Rhizoma Typhonii, Fructus Evodiae, Folium Camelliae sinensis medicine to be combined, make each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat headache.Wherein select Rhizoma Et Radix Notopterygii to be because its nature and flavor are arduous, temperature, enter bladder, kidney channel, and loose exterior cold is arranged, wind-damp dispelling, and the function in sharp joint, the wind and cold that cures cold, have a headache lossless, anemofrigid-damp arthralgia, stiffness of the nape muscular contracture, joint ache, edema due to wind pathogen edema, skin sore.Selecting Rhizoma Chuanxiong is because its nature and flavor suffering, and temperature, enter liver, gallbladder meridian, and activating QI to alleviate the depression is arranged, dispeiling pathogenic wind and removing dampness, the function of promoting blood circulation and stopping pain, control air-cooled headache revolve dizzy, hypochondriac pain abdomen pain, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation piece pain, ulcer sores.Selecting Herba Schizonepetae is that temperature, enter lung, Liver Channel, delivers because of its nature and flavor suffering, dispel the wind, and the function for the treatment of blood disorders, the parch to black hemostasis, the heating that cures cold, headache, laryngopharynx swelling and pain, the apoplexy locked mouth, spit blood, and epistaxis, have blood in stool, metrorrhagia, puerperal blood faints, carbuncle, skin ulcer scabies, scrofula.Selecting Radix Saposhnikoviae is that temperature, enter bladder, lung, spleen channel, delivers because of its property acrid-sweet flavor, dispels the wind, and victory is wet, and the function of pain relieving, control affection of exogenous wind-cold, and headache is dizzy, stiffness of the nape, and anemofrigid-damp arthralgia, joint is ached, and the extremity contraction is anxious, tetanus.Selecting Herba Asari is that temperature, enter lung, kidney channel because of its nature and flavor suffering, dispel the wind, and cold expelling, row water, open the function of stealing, and controls air-cooled headache, nasal sinusitis, pain relieving, phlegm retention cough with dyspnea, rheumatic arthralgia.Selecting the Radix Angelicae Dahuricae is that temperature, enter lung, spleen, stomach warp because of its nature and flavor suffering, dispel the wind, and dampness, detumescence, the function of pain relieving, control headache, supraorbital bone pain, toothache, nasal sinusitis, cold-damp stomachache, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus due to dryness, scabies.Select Rhizoma Cimicifugae to be because the micro-hardship of the sweet suffering of its nature and flavor is cool, enter lung, spleen, stomach warp, yang invigorating is arranged, deliver rash, the function of removing toxic substances, control seasonal epidemic pathogens epidemic disease labor, the headache cold and heat, and laryngalgia, the aphtha scar, macule is not saturating, sinking of QI of middle-JIAO, chronic diarrhea chronic dysentery, proctoptosis, women's metrorrhagia and leukorrhagia, uterus tenesmus, carbuncle sore tumefacting virus.Selecting Rhizoma Ligustici is that temperature, have dispersing wind and cold because of its nature and flavor suffering, except the function of damp, treats headche due to wind-cold, and cold-damp stomachache, have loose bowels, scabies.Selecting Herba Menthae is because its nature and flavor suffering, cool, enters lung, Liver Channel, and dispelling wind is arranged, and heat radiation is warded off dirtyly, and the function of removing toxic substances, control affection due to external wind and heat, headache, conjunctival congestion, laryngopharynx swelling and pain, dyspepsia flatulence, aphtha, toothache, skin ulcer scabies, urticaria.Select Radix Platycodonis to be because its nature and flavor toil is flat, enter lung, stomach warp, lung qi dispersing gas is arranged out, the function of the evacuation of pus of eliminating the phlegm, control the exogenous cough, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, dysentery stomachache.Select Radix Bupleuri to be because its nature and flavor hardship is cool, enter liver, gallbladder meridian, reconciling superficies and interior is arranged, soothing the liver, the function of yang invigorating, control alternate attack of chill and fever, fullness in the chest and hypochondriac pain, bitter taste deafness, headache and dizziness, malaria, diarrhea proctoptosis, menoxenia, uterine prolapse.Select Radix Puerariae to be because the sweet suffering of its nature and flavor is flat, enter spleen, stomach warp, the yang invigorating expelling pathogenic factors from muscles is arranged, rash antidiarrheal, the function that relieving restlessness is only drunk, cure the wound cold, cures the wound cold, warm headache stiffness of the nape, dysphoria with smothery sensation is quenched one's thirst, has loose bowels, dysentery, skin eruption is not saturating, hypertension, angina pectoris, deafness.Select Radix Glycyrrhizae to be because its nature and flavor are sweet flat, enter spleen, stomach, lung meridian, have and middle emergency, lung moistening, removing toxic substances, the function of coordinating the actions of various ingredients in a prescription, process with controlling weakness of the spleen and stomach lack of appetite, stomachache loose stool, the overstrain heating, consumptive lung disease cough, cardiopalmus, frightened carbuncle, give birth to controlling laryngopharynx swelling and pain, peptic ulcer, ulcer sores, separate poison of drug and alimentary toxicosis.Select Radix Angelicae Pubescentis to be because its nature and flavor are arduous, temperature, enter kidney, urinary bladder channel, dispels the wind, and victory is wet, cold expelling, and the function of pain relieving, control anemofrigid-damp arthralgia, waist urushic acid pain, trick spasm and pain, chronic tracheitis, headache, toothache.Select Herba Ephedrae to be because its nature and flavor are arduous, temperature, enter lung, urinary bladder channel, and diaphoresis is arranged, and relievings asthma, the function of diuretic, the cold table that cures the wound is real, and fever with chills is lossless, headache is had a stuffy nose, arthralgia, cough and asthma, edema due to wind pathogen edema; dysuria, ailment said due to cold or exposure insensitive impediment, munbness, rubella pruritus.Select Radix Scutellariae to be because its nature and flavor bitter cold enters cardiopulmonary, gallbladder, large intestine channel, the removing the relative excess fire is arranged, except damp and hot, the function of arresting bleeding and miscarriage prevention, control the high fever excessive thirst, the cough due to lung-heat.Select Gypsum Fibrosum to be because its property acrid-sweet flavor is cold, enter lung, stomach warp, give birth to expelling pathogenic factors from muscles for clearing heat is arranged, the function that relieving restlessness is quenched the thirst, control the calentura high fever and do not move back, vexed coma, delirium is gone mad, thirsty and dry pharynx, lung-heat dyspnea with rapid respiration, the heatstroke spontaneous perspiration, stomach-fire headache, toothache, hyperactivity of toxic heat, send out the speckle dermexanthesis, aphtha of the mouth and tongue, forge deposited promoting tissue regeneration and ulcer healing, the external treatment ulcer sores, burst and do not regain, the burning hot wound of soup.Chosen because of their sexual Arisaema Bitterpungent, temperature, toxic, lungs, liver, spleen, dampness and phlegm, chills and shock, reducing swelling function, cure stroke phlegm, oblique of eye and mouth, hemiplegia, epilepsy, convulsions, tetanus, wind phlegm dizziness, pharyngitis, scrofula, carbuncles, or flutter off injured, snake bites.Selecting the Rhizoma Pinelliae is because of its nature and flavor suffering, and temperature is poisonous, enters spleen, stomach warp, and drying dampness to eliminate phlegm is arranged, stopping nausea and vomiting by lowering the adverse flow of QI, and the function of dissolving lump and resolving mass, control the damp-phlegm cold drink, vomiting, regurgitation, cough with asthma abundant expectoration, chest and diaphragm distension, syncope due to accumulation of phlegm headache, dizzy sleeplessness, outer subduing inflammation.Selecting Rhizoma Typhonii is that temperature, return stomach, Liver Channel because of its nature and flavor suffering, the expectorant that dispels the wind, and the antispasmodic function, control apoplexy, facial hemiparalysis, facial paralysis, migraine, tetanus, tuberculous lymphadenitis, carbuncle.Select Fructus Evodiae to be because its nature and flavor are arduous, temperature, poisonous, enter liver, stomach warp, warming middle-JIAO is arranged, pain relieving, regulate the flow of vital energy, the function of dampness, the contrary acid regurgitation of stopping vomiting, headache due to JUE YIN disorder, the coldness of ZANG-organ is vomited and diarrhoea, abdominal distention, beriberi, hernia, aphthous ulcer, toothache, eczema, impetigo.Selecting Folium Camelliae sinensis is that cool, GUIXIN lung stomach warp, have and reduce phlegm because of its property bitter but sweet flavor, helps digestion, and the function of diuresis removing toxic substances, control the headache blurred vision, and food stagnation expectorant is stagnant, malaria, dysentery.

The specific embodiment

The drug dose of the present invention's combination is also that the inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect in the following weight scope

Rhizoma Et Radix Notopterygii 10-20 gram Rhizoma Chuanxiong 10-20 gram Herba Schizonepetae 10-20 gram

Radix Saposhnikoviae 10-20 gram Herba Asari 8-15 gram Radix Angelicae Dahuricae 8-15 gram

Rhizoma Cimicifugae 8-15 gram Rhizoma Ligustici 8-15 gram Herba Menthae 8-15 gram

Radix Platycodonis 8-15 gram Radix Bupleuri 8-15 gram Radix Puerariae 8-15 gram

Radix Glycyrrhizae 8-15 gram Radix Angelicae Pubescentis 10-20 gram Herba Ephedrae 10-20 gram

Radix Scutellariae 10-20 gram Gypsum Fibrosum 10-20 gram Rhizoma Arisaematis 10-20 gram

Rhizoma Pinelliae 10-20 gram Rhizoma Typhonii 10-20 gram Fructus Evodiae 10-20 gram

Folium Camelliae sinensis 10-20 gram

Preferable amount is

Rhizoma Et Radix Notopterygii 15 gram Rhizoma Chuanxiong 15 gram Herba Schizonepetae 15 grams

The Radix Saposhnikoviae 15 gram Herba Asari 10 gram Radix Angelicae Dahuricae 10 grams

Rhizoma Cimicifugae 10 gram Rhizoma Ligustici 10 gram Herba Menthae 10 grams

Radix Platycodonis 10 gram Radix Bupleuri 10 gram Radix Puerariae 10 grams

Radix Glycyrrhizae 10 gram Radix Angelicae Pubescentis 15 gram Herba Ephedrae 15 grams

Radix Scutellariae 15 gram Gypsum Fibrosum 15 gram Rhizoma Arisaematis 15 grams

The Rhizoma Pinelliae 15 gram Rhizoma Typhonii 15 gram Fructus Evodiae 15 grams

Folium Camelliae sinensis 15 grams

The preparation method of medicine of the present invention is as follows

One, get the raw materials ready

1, Rhizoma Et Radix Notopterygii: choose decontamination, clean, run through, section, dry;

2, Rhizoma Chuanxiong: choose decontamination, separate large and small, be soaked in water, solarization is dried in the air, after moistening, cuts into slices, and drying;

3, Herba Schizonepetae: choose clean impurity, water is bubble slightly, pulls cutting out, dries;

4, Radix Saposhnikoviae: remove residual stem, be soaked in water, pull out, run through section, dry;

5, Herba Asari: Ex-all impurity, water spray profit, cutting in time, dry;

6, the Radix Angelicae Dahuricae: choose clean impurity, wash, soak, pull out and run through, slightly shine to crust during without soapy feeling, then after moistening, chip drying;

7, Rhizoma Cimicifugae: choose decontamination, slightly foam washing is clean, pulls out, runs through, and section, dry;

8, Rhizoma Ligustici: remove residual stem, choose clean impurity, clean, run through rear section, dry;

9, Herba Menthae: choose clean impurity, remove undesirable root, first leaf is trembled and separately put down, then stem is sprayed to clear water, run through rear cutting, dry, then with leaf and even;

10, Radix Platycodonis: choose clean impurity, except removing LU, clean and pull out, run through rear section, dry;

11, Radix Bupleuri: choose decontamination, remove residual stem, clean silt, pull out, run through rear timely section, dry immediately;

12, Radix Puerariae: choose decontamination, clean, be soaked in water, pull out, run through, section, dry in time;

13, Radix Glycyrrhizae: choose decontamination, clean, be soaked in water and, pull out thoroughly the time to eighty per cant, run through section, airing;

14, Radix Angelicae Pubescentis: choose decontamination, separately size, clean, and runs through rear section, drying;

15, Herba Ephedrae: choose decontamination, remove most woody stems and undesirable root, wash, cutting after micro-profit, be drying to obtain;

16, Radix Scutellariae: choose decontamination, remove residual stem, with cold water, infiltrate or put in boiled water and slightly soak and pull out, section, dry;

17, Gypsum Fibrosum: remove assorted stone, clean earth, be broken into fritter;

18, Rhizoma Arisaematis: choose decontamination, clean the ash bits, dry;

19, the Rhizoma Pinelliae: choose decontamination, sieve dedust bits;

20, Rhizoma Typhonii: get crude drug, remove impurity, cleaning, drying;

21, Fructus Evodiae: get crude drug, remove fruit stem, branch and impurity, sieve removes chip;

22, Folium Camelliae sinensis: after bright leaf gathers, through completing, knead, drying is made green tea.

Two, preparation

1, by the Rhizoma Et Radix Notopterygii of described weight, Rhizoma Chuanxiong, Herba Schizonepetae, Radix Saposhnikoviae, Herba Asari, the Radix Angelicae Dahuricae, Rhizoma Cimicifugae, Rhizoma Ligustici, Herba Menthae, Radix Platycodonis, Radix Bupleuri, Radix Puerariae, Radix Glycyrrhizae, Radix Angelicae Pubescentis, Herba Ephedrae, Radix Scutellariae, Gypsum Fibrosum, Rhizoma Arisaematis, the Rhizoma Pinelliae, Rhizoma Typhonii, Fructus Evodiae, tea raw material medicine, add 8 times of amounts of water, soak after 150 minutes, intense fire decocts boiling 20 minutes, use again slow fire boiling 40 minutes, filter to obtain decoction liquor for the first time.

2, the medicinal residues of filtration are added to 4 times of amounts of water, intense fire decocts boiling 10 minutes, then uses slow fire boiling 20 minutes, filters to obtain decoction liquor for the second time.

3,, by twice decoction liquor mixing and stirring, be divided into 3 doses and take.

Medicine of the present invention has heat radiation, delivers, and dispels the wind, and victory is wet, pain relieving, and warming middle-JIAO, the effect of regulating the flow of vital energy, treatment headache instant effect, short treating period, do not recur.

Below further set forth the beneficial effect of medicine of the present invention by test example, these tests comprise animal toxicity test report and the clinical observation material of medicine of the present invention.

The animal toxicity test report of [test example 1] medicine of the present invention

Get 30 of rabbit, male and female dual-purpose, body weight 2.0-2.3kg, divide two groups, 15 every group, wherein one group is the normal amount toxicity test, another group is the super quantity toxicity test, and the normal amount group is 10ml/kg, and the excess group is 20ml/kg, administering mode is the administration by gavage administration, every day twice, be used in conjunction 7 days, observes the administration reaction every day, it is normal that result of the test shows that two groups of families exempt from diet activity, and medicine is without bad toxic and side effects.

The clinical observation material of [test example 2] medicine of the present invention

1, physical data

Accept out-patient's 270 examples for medical treatment, male patient's 110 examples, female patient 160 examples.

2, diagnostic criteria

The headache degree has gently to be had heavily, and it is short that pain time has length to have.The pain form is varied, common distending pain, vexed pain, tears sample pain, electric shock sample pain, prickling-like pain, and part is with vascular pulsation sense and the sense of head lock ring, and feel sick, vomiting, the symptom such as dizzy.The Secondary cases headache also can be with other system disease symptoms or sign, and as infectious disease, often with heating, vascular lesion is often accompanied the neurologic impairment symptoms such as hemiplegia, aphasia etc.Headache produces different harm according to degree, is in a bad way and can makes the patient lose the live and work ability.

3, Therapeutic Method

Select above-mentioned medicament, take to the patient, every day, early, middle and late respectively the clothes 1 time, 10 days be a course for the treatment of, takes continuously 4 courses for the treatment of.

4, efficacy assessment standard

Produce effects: transference cure, it is normal that body constitution is recovered, and observes 1 year without the recidivist;

Take a turn for the better: the state of an illness is clearly better, and body constitution is progressively recovered.

Invalid: as not reach improvement standard person.

5, therapeutic outcome (seeing the following form)

In above-mentioned treatment, by Drug therapy headache 270 examples of the present invention, produce effects 255 examples as a result, obvious effective rate is 94.45%, 9 examples that take a turn for the better, improvement rate is 3.33%, invalid 6 examples, total effective rate is 97.78%.

Claims (3)

1. a medicine for the treatment of headache, it is characterized in that: it is to be made by the crude drug in following weight range:

Rhizoma Et Radix Notopterygii 10-20 gram Rhizoma Chuanxiong 10-20 gram Herba Schizonepetae 10-20 gram

Radix Saposhnikoviae 10-20 gram Herba Asari 8-15 gram Radix Angelicae Dahuricae 8-15 gram

Rhizoma Cimicifugae 8-15 gram Rhizoma Ligustici 8-15 gram Herba Menthae 8-15 gram

Radix Platycodonis 8-15 gram Radix Bupleuri 8-15 gram Radix Puerariae 8-15 gram

Radix Glycyrrhizae 8-15 gram Radix Angelicae Pubescentis 10-20 gram Herba Ephedrae 10-20 gram

Radix Scutellariae 10-20 gram Gypsum Fibrosum 10-20 gram Rhizoma Arisaematis 10-20 gram

Rhizoma Pinelliae 10-20 gram Rhizoma Typhonii 10-20 gram Fructus Evodiae 10-20 gram

Folium Camelliae sinensis 10-20 gram.

2. medicine according to claim 1, wherein the consumption of each crude drug is:

Rhizoma Et Radix Notopterygii 15 gram Rhizoma Chuanxiong 15 gram Herba Schizonepetae 15 grams

The Radix Saposhnikoviae 15 gram Herba Asari 10 gram Radix Angelicae Dahuricae 10 grams

Rhizoma Cimicifugae 10 gram Rhizoma Ligustici 10 gram Herba Menthae 10 grams

Radix Platycodonis 10 gram Radix Bupleuri 10 gram Radix Puerariae 10 grams

Radix Glycyrrhizae 10 gram Radix Angelicae Pubescentis 15 gram Herba Ephedrae 15 grams

Radix Scutellariae 15 gram Gypsum Fibrosum 15 gram Rhizoma Arisaematis 15 grams

The Rhizoma Pinelliae 15 gram Rhizoma Typhonii 15 gram Fructus Evodiae 15 grams

Folium Camelliae sinensis 15 grams.

3. according to the preparation method of claim 1 or 2 described medicine, it comprises the following steps:

(1) get the raw materials ready

(1) Rhizoma Et Radix Notopterygii: choose decontamination, clean, run through, section, dry;

(2) Rhizoma Chuanxiong: choose decontamination, separate large and small, be soaked in water, solarization is dried in the air, after moistening, cuts into slices, and drying;

(3) Herba Schizonepetae: choose clean impurity, water is bubble slightly, pulls cutting out, dries;

(4) Radix Saposhnikoviae: remove residual stem, be soaked in water, pull out, run through section, dry;

(5) Herba Asari: Ex-all impurity, water spray profit, cutting in time, dry;

(6) Radix Angelicae Dahuricae: choose clean impurity, wash, soak, pull out and run through, slightly shine to crust during without soapy feeling, then after moistening, chip drying;

(7) Rhizoma Cimicifugae: choose decontamination, slightly foam washing is clean, pulls out, runs through, and section, dry;

(8) Rhizoma Ligustici: remove residual stem, choose clean impurity, clean, run through rear section, dry;

(9) Herba Menthae: choose clean impurity, remove undesirable root, first leaf is trembled and separately put down, then stem is sprayed to clear water, run through rear cutting, dry, then with leaf and even;

(10) Radix Platycodonis: choose clean impurity, except removing LU, clean and pull out, run through rear section, dry;

(11) Radix Bupleuri: choose decontamination, remove residual stem, clean silt, pull out, run through rear timely section, dry immediately;

(12) Radix Puerariae: choose decontamination, clean, be soaked in water, pull out, run through, section, dry in time;

(13) Radix Glycyrrhizae: choose decontamination, clean, be soaked in water and, pull out thoroughly the time to eighty per cant, run through section, airing;

(14) Radix Angelicae Pubescentis: choose decontamination, separately size, clean, and runs through rear section, drying;

(15) Herba Ephedrae: choose decontamination, remove most woody stems and undesirable root, wash, cutting after micro-profit, be drying to obtain;

(16) Radix Scutellariae: choose decontamination, remove residual stem, with cold water, infiltrate or put in boiled water and slightly soak and pull out, section, dry;

(17) Gypsum Fibrosum: remove assorted stone, clean earth, be broken into fritter;

(18) Rhizoma Arisaematis: choose decontamination, clean the ash bits, dry;

(19) Rhizoma Pinelliae: choose decontamination, sieve dedust bits;

(20) Rhizoma Typhonii: get crude drug, remove impurity, cleaning, drying;

(21) Fructus Evodiae: get crude drug, remove fruit stem, branch and impurity, sieve removes chip;

(22) Folium Camelliae sinensis: after bright leaf gathers, through completing, knead, drying is made green tea;

(2) preparation

(1) by the Rhizoma Et Radix Notopterygii of described weight, Rhizoma Chuanxiong, Herba Schizonepetae, Radix Saposhnikoviae, Herba Asari, the Radix Angelicae Dahuricae, Rhizoma Cimicifugae, Rhizoma Ligustici, Herba Menthae, Radix Platycodonis, Radix Bupleuri, Radix Puerariae, Radix Glycyrrhizae, Radix Angelicae Pubescentis, Herba Ephedrae, Radix Scutellariae, Gypsum Fibrosum, Rhizoma Arisaematis, the Rhizoma Pinelliae, Rhizoma Typhonii, Fructus Evodiae, tea raw material medicine, add 8 times of amounts of water, soak after 150 minutes, intense fire decocts boiling 20 minutes, use again slow fire boiling 40 minutes, filter to obtain decoction liquor for the first time;

(2) medicinal residues of filtration are added to 4 times of amounts of water, intense fire decocts boiling 10 minutes, then uses slow fire boiling 20 minutes, filters to obtain decoction liquor for the second time;

(3), by twice decoction liquor mixing and stirring, be divided into 3 doses and take.