CN104887808A

CN104887808A - Periodontitis treatment traditional Chinese medicine preparation

Info

Publication number: CN104887808A
Application number: CN201510365136.7A
Authority: CN
Inventors: 王艳娣
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-06-29
Filing date: 2015-06-29
Publication date: 2015-09-09

Abstract

The invention discloses a periodontitis treatment traditional Chinese medicine preparation comprising internal medicine and external medicine. The raw materials of the internal medicine include, be weight: garcinia mangostana, stipa sibirica, beach morningglory root, twinleaf zornia root, common wedgelet fern herb, berchemia lineata, shinyleaf pricklyash root, threevein aster herb, catchweed bedstraw herb, gossamer urocteae, androsace umbellata, salix leaf, oriental blechnum frond, coptis chinensis, Chinese waxmyrtle bark, convolvulus arvensis, tongol aster herb and borneol; the raw materials of the external medicine include alum, borneol, peppermint leaf, Chinese red pepper, garcinia mangostana, stipa sibirica, beach morningglory root, twinleaf zornia root, common wedgelet fern herb, berchemia lineata and shinyleaf pricklyash root. The ingredients are utilized in a combined manner, the effects of diminishing inflammation, relieving the pain, clearing heat, detoxifying and deswelling are achieved, the traditional Chinese medicines are adopted as raw materials, and the compound are prepared according to the theory of traditional Chinese medical science.

Description

A kind of Chinese medicine preparation for the treatment of periodontitis

Technical field

The invention belongs to the field of Chinese medicines, specifically a kind of Chinese medicine preparation for the treatment of periodontitis.

Background technology

The chronic inflammatory disease of the Periodontal Supporting Tissue that periodontitis is mainly caused by local factor.Age of onset is later comparatively common with 35 years old.As gingivitis fails to treat in time, inflammation can be diffused into periodontal membrane, alveolar bone and cementum by gingiva to deep layer and develop into periodontitis.Due to early stage how easily out in the cold without obvious subjective symptoms, comparatively serious in time having symptom, even can not retain tooth.Periodontitis is the chronic inflammatory disease invading gingiva and periodontal tissue, and be a kind of destructive disease, its principal character is periodontal pocketformation and the inflammation of bag wall, frontal resorption and tooth loosen gradually, and it is the main cause causing adult's loss of tooth.Primary disease is many because bacterial plaque, tartar, food impaction, and ill fitting prosthesis, stings wound etc. and cause, various focusing depths represented swelling, makes bacterial plaque pile up simultaneously and increases the weight of, and prolongs by expanding under gingivally on gum.Due to microecological environment under gum, grow the Periodontal Pathogens that virulence is larger in a large number in subgingival plaque, as gingiva bacteroid, intermediate bacillus, spirillums etc., make the increased inflammation of gingiva and expand to prolong, cause periodontal pocket to be formed and frontal resorption, cause periodontitis.

Early symptom is not obvious, and patient often only has the performance of Secondary cases gingival hemorrhage or halitosis, similar to symptoms of gingivitis.The swelling of visible gum edge, gum nipple and attached gingiva during inspection, matter are soft, in peony or kermesinus, visit examine easily hemorrhage.Along with the further diffusion of inflammation, there is following symptoms:

1. periodontal pocket is formed

Due to the expansion of inflammation, periodontal membrane is destroyed, and alveolar bone absorbs gradually, and gingiva is separated with root of the tooth, makes gingival sulcus deepen and form periodontal pocket.Depth of pocket surveyed by available probe.

2. periodontal pyorrhea

Periodontal pocket wall has ulcer and struvite granulation tissue to be formed, and has purulent secretion to retain in bag, thus flicking gingiva, visible pyorrhea.And often have halitosis.

3. odontoseisis

Because periodontal tissue is destroyed, when particularly frontal resorption increases the weight of, there is the phenomenon such as odontoseisis, displacement in abutment's tooth forces quantity not sufficient.Now patient often feels unable, the dull pain of occlusion, and gingival hemorrhage and halitosis increase the weight of.

When Abwehrkraft des Koepers reduce, periodontal pocket sepage inadequate drainage time, can form periodontal abscess, be that periodontitis develops into late period, occurs one of dark periodontal pocket common concomitant symptom.Now gingiva is oval projection, rubescent swelling, surface-brightening; Tooth mobility increases, and kowtows pain; Patient is with the violent jumping pain in local.Meanwhile, patient can have body temperature rising, general malaise, the symptoms such as submandibular lymph nodes enlargement, tenderness.

Physician of all times is in continuous exploration, and create the medicine of a large amount for the treatment of periodontal disease, most medicine is all " curing the symptoms, not the disease ".Some effective formula can only because of people side, and often the cause of disease is not suited the medicine to the illness and poor effect.

Summary of the invention

The present invention, in order to solve the deficiencies in the prior art part, provides a kind of Chinese medicine preparation for the treatment of periodontitis.

A kind of Chinese medicine preparation for the treatment of periodontitis of the present invention, by the configuration of clinic tests and repeated verification for many years, meet the theory of Chinese medicine.Formula take Chinese herbal medicine as raw material, required composition is made through selection → oven dry → pulverizing etc., powder agent, medicament, tablet, capsule is made again after composite, periodontitis treatment need from adjusting general body state, very important to treatment local patholoic change, Just because of this, the present invention's Therapeutic Method from inside to outside, both ensure that curative effect, reach treating both the principal and secondary aspects of a disease again.

A kind of Chinese medicine preparation for the treatment of periodontitis, comprise oral medicine and medicine for external use, wherein oral medicine is made up of the raw material of Chinese medicine of following weight portion: medicine for external use is Alumen, Borneolum Syntheticum, mentha leave, Pericarpium Zanthoxyli, Cortex Garciniae, Herba oxytropis glabrae, Ipomoea pescaprae(L.) Sweet, Radix Zornia Diphyllae, Folium Stenolomatis, Radix berchemiae lineatae, Radix Zanthoxyli is made, oral medicine is by Cortex Garciniae, Herba oxytropis glabrae, Ipomoea pescaprae(L.) Sweet, Radix Zornia Diphyllae, Folium Stenolomatis, Radix berchemiae lineatae, Radix Zanthoxyli, Herba Asteris Ageratoidis, Herba Galii Teneri, Uroctea compatilis Koch., Herba Androsaces Umbellatae (Herba Androsaces Coccineae), Folium Salicis Babylonicae, Folium Blechni orientalis, Rhizoma Coptidis, Cortex Myricae Rubrae, Herba seu Flos Convolvuli arvensis, Aster dubius (Thunb.) Onno, Borneolum Syntheticum is made.All medicines share, and have anti-inflammatory analgetic, heat-clearing and toxic substances removing, effect of detumescence, and the present invention uses the Chinese medicine of Chinese tradition for raw material, use the theory of Chinese medicine to develop.

Treat a Chinese medicine preparation for periodontitis, comprise medicine for external use and oral medicine, wherein medicine for external use is made up of the raw material of Chinese medicine compatibility of following weight portion:

Alumen 10-20 part, Borneolum Syntheticum 10-20 part, mentha leave 10-20 part, Pericarpium Zanthoxyli 10-20 part, Cortex Garciniae 5-10 part, Herba oxytropis glabrae 5-10 part, Ipomoea pescaprae(L.) Sweet 5-10 part, Radix Zornia Diphyllae 5-10 part, Folium Stenolomatis 5-10 part, Radix berchemiae lineatae 5-10 part, Radix Zanthoxyli 5-10 part;

The preparation method of medicine for external use:

According to formula proportion above raw material carried out choosing → drying → be crushed to 200-300 order fine powder → mix homogeneously to get product;

Be sprayed on marginal gingiva during use, after sucking several minutes, gargled; Or gargle after medicated powder being diluted with water.

Oral medicine is formed by the raw material of Chinese medicine compatibility of following weight portion:

Cortex Garciniae 10-15 part, Herba oxytropis glabrae 10-15 part, Ipomoea pescaprae(L.) Sweet 10-15 part, Radix Zornia Diphyllae 10-15 part, Folium Stenolomatis 10-15 part, Radix berchemiae lineatae 10-15 part, Radix Zanthoxyli 10-15 part, Herba Asteris Ageratoidis 10-15 part, Herba Galii Teneri 10-15 part, Uroctea compatilis Koch. 15-20 part, Herba Androsaces Umbellatae (Herba Androsaces Coccineae) 15-20 part, Folium Salicis Babylonicae 15-20 part, Folium Blechni orientalis 15-20 part, Rhizoma Coptidis 15-20 part, Cortex Myricae Rubrae 15-20 part, Herba seu Flos Convolvuli arvensis 15-20 part, Aster dubius (Thunb.) Onno 15-20 part, Borneolum Syntheticum 15-20 part;

Oral medicine preparation method:

By formula proportion above-mentioned Chinese medicine is chosen → is dried → be crushed to 300-400 order fine powder → mix homogeneously after incapsulate and get product.

Three times one time on the oral one three.

Alumen 12-18 part, Borneolum Syntheticum 12-18 part, mentha leave 12-18 part, Pericarpium Zanthoxyli 12-18 part, Cortex Garciniae 6-9 part, Herba oxytropis glabrae 6-9 part, Ipomoea pescaprae(L.) Sweet 6-9 part, Radix Zornia Diphyllae 6-9 part, Folium Stenolomatis 6-9 part, Radix berchemiae lineatae 6-9 part, Radix Zanthoxyli 6-9 part;

Cortex Garciniae 12-14 part, Herba oxytropis glabrae 12-14 part, Ipomoea pescaprae(L.) Sweet 12-14 part, Radix Zornia Diphyllae 12-14 part, Folium Stenolomatis 12-14 part, Radix berchemiae lineatae 12-14 part, Radix Zanthoxyli 12-14 part, Herba Asteris Ageratoidis 12-14 part, Herba Galii Teneri 12-14 part, Uroctea compatilis Koch. 16-18 part, Herba Androsaces Umbellatae (Herba Androsaces Coccineae) 16-18 part, Folium Salicis Babylonicae 16-18 part, Folium Blechni orientalis 16-18 part, Rhizoma Coptidis 16-18 part, Cortex Myricae Rubrae 16-18 part, Herba seu Flos Convolvuli arvensis 16-18 part, Aster dubius (Thunb.) Onno 16-18 part, Borneolum Syntheticum 16-18 part.

Alumen 15 parts, Borneolum Syntheticum 15 parts, mentha leave 15 parts, 15 parts, Pericarpium Zanthoxyli, Cortex Garciniae 8 parts, Herba oxytropis glabrae 8 parts, Ipomoea pescaprae(L.) Sweet 8 parts, Radix Zornia Diphyllae 8 parts, Folium Stenolomatis 8 parts, Radix berchemiae lineatae 8 parts, Radix Zanthoxyli 8 parts;

Cortex Garciniae 13 parts, Herba oxytropis glabrae 13 parts, Ipomoea pescaprae(L.) Sweet 13 parts, Radix Zornia Diphyllae 13 parts, Folium Stenolomatis 13 parts, Radix berchemiae lineatae 13 parts, Radix Zanthoxyli 13 parts, Herba Asteris Ageratoidis 13 parts, Herba Galii Teneri 13 parts, Uroctea compatilis Koch. 17 parts, Herba Androsaces Umbellatae (Herba Androsaces Coccineae) 17 parts, Folium Salicis Babylonicae 17 parts, Folium Blechni orientalis 17 parts, Rhizoma Coptidis 17 parts, Cortex Myricae Rubrae 17 parts, Herba seu Flos Convolvuli arvensis 17 parts, Aster dubius (Thunb.) Onno 17 parts, Borneolum Syntheticum 17 parts.

the herbal pharmacology that the present invention relates to and the property of medicine as follows:

Alumen:

[meridian distribution of property and flavor] sour in the mouth, cold.Enter spleen channel.

The sputum of [function] vomiting and diarrhea wind heat, gets its sour and bitter flavors can cause of vomiting and diarrhea also; Control all disorders of blood, proctoptosis, the prolapse of the uterus, skin infection, get its sour and astringent and receive also; Control phlegm retention, let out profit, metrorrhagia and leukorrhagia, wind-eye, get its receive and dampness also; Control sore throat, carbuncle of yin nature, middle legendary venomous insect, snakeworm hinder Trionyx sinensis Wiegmann, get its removing toxic substances also.

Pericarpium Zanthoxyli:

[meridian distribution of property and flavor] acrid in the mouth, warm in nature.Slightly poisonous.Return spleen, stomach, kidney channel.

[effect] has the function of warming middle-JIAO to relieve pain, killing parasites for relieving itching.Pericarpium Zanthoxyli is slightly poisonous, and pungent using warming therapy is very strong, and the effect of external killing parasites for relieving itching is good.For scabies, eczema or skin pruritus.Take pepper water and can remove parasite; Have fragranceeffect of stomach invigorating, warming spleen and stomach for dispelling cold, removing damp and stopping pain, parasite killing removing toxic substances, antipruritic solution raw meat.

[pharmacology] bacteriostatic test: Pericarpium Zanthoxyli is to anthrax bacillus, Hemolytic streptococcus, diphtheria corynebacterium, Diplococcus pneumoniae, golden yellow staphylococcus, lemon yellow and 10 kinds of gram positive bacterias such as Staphylococcus albus, bacillus subtilis, and escherichia coli, Song Nei Shi dysenterythe enteral pathogenic bacterium such as bar flute, Bacillus proteus, typhoid fever and Salmonella paratyphi, bacillus pyocyaneus, vibrio cholera all have significantly inhibitory action.The water logging agent of 1:4 also has inhibitory action to star nocardia.According to animal experiment, a small amount of clothes that continue can promote relevant metabolic body of glandgrow, volume then can promote the glandular development about reproduction.This just demonstrates the understanding of ancients' " temperature male wind-supplying kidney ".

Borneolum Syntheticum:

[meridian distribution of property and flavor] acrid in the mouth, hardship, be slightly cold; GUIXIN, spleen, lung hydrocarbon.

[function] has one's ideas straightened out refreshment, clearing away heat to alleviate pain.

ancient books is made a summary

1. " newly Revised Canon of Materia Medica": " main trusted subordinate pathogen, rheumatismgather, deaf, improving eyesight, go conjunctival congestion skin nebula.”

2. Compendium of Material Medica: " treatment sore throat, headache, nose Xi, toothache, typhoid fever protrusion of the tongue, children's's pox fall into.Logical all keys, loose stagnated fire.”

3. " medical center bun want ": " Borneolum Syntheticum master falls apart stagnated fire, can deep heat, controls infantile convulsion, expectorant fan, sore throat, and swelling of the tongue, toothache, deafness, breath, conjunctival congestion cataract, pox poison cave in, parasite killing, hemorrhoid, expedite the emergence of, and property is walked and do not keep, also can granulation promoting pain relieving ^[1].So loose and easily exhaust, be that YIN-cold is also after all.”

Mentha leave:

[meridian distribution of property and flavor] is cool in nature, acrid in the mouth;

The effect of [function] irritation causes trachea to produce new secretion, and makes the mucus of stiff be easy to get rid of, therefore has the effect of eliminating the phlegm, sterilizing.

It is one of Chinese conventional Chinese medicine.It is pungent cool property sweating antipyretic medicine, controls influenza, the disease such as headache, conjunctival congestion, fever of the body, throat, dental bed swell and ache.Place uses can training the mind dysmenorrhoea, skin pruritus, erythra and eczema etc.The Herba Menthae of light friend Greenhouse Fruit Picking is again the fresh vegetable on dining table in the Spring Festival.Clearly good to eat.Usually with Herba Menthae for tea, clear away heart-fire improving eyesight.Herba Menthae has extremely strong sterilization antibacterial action, often drinks its energy preventing viral flu, oral disease, makes breath freshening.Gargle with mint tea juice, can prevent halitosis.Steam face with mint tea mist, also have the effect of shrinking pore.Apply by the blade steeping tea and can feel refrigerant on eyes, can eyestrain be removed.It is said and can be used for the another name that Herba Menthae also has " eyes grass " treating ophthalmic.

Cortex Garciniae:

Return through hardship puckery cool

function cures mainly anti-inflammatory analgetic convergence granulation promoting for enteritis infantile dyspepsia stomach duodenal ulcer, Peptic Ulcers hyporrhea stomatitis periodontitis burn and scald is controlled in external ulcer of the lower limb eczema

Herba oxytropis glabrae:

function cures mainly

Anesthesia calm pain relieving control arthralgia toothache neurasthenia skin pruritus

Radix Primulae sieboldii:

[nature and flavor] " Ningxia Chinese herbal medicine handbook ": sweet is flat.

[function cures mainly] reduces phlegm, cough-relieving, relieving asthma.For phlegm dyspnea cough, upper respiratory tract infection, pharyngitis, the diseases such as bronchitis.

Ipomoea pescaprae(L.) Sweet:

Cure mainly the effects such as acute toothache, articular rheumatic pain, erysipelas, eczema.

1. acute toothache is controlled: Herba Ipomoeae Pes-Capraes fresh each four to five liang (dry two halves).Be decocted in water for oral dose.(" Quanzhou book on Chinese herbal medicine ")

2. control articular rheumatic pain: the dry root one or two of Herba Ipomoeae Pes-Capraes, decocting adjusts brown sugar or wine clothes.

3. erysipelas (filaricide causes lymphangitis) is controlled: the dry root one or two of Herba Ipomoeae Pes-Capraes, hair beauty dried fruits root one or two, the dry root one or two of Ramulus et Folium Berchemiae Lineatae.Be decocted in water for oral dose.

4. eczema is controlled: Herba Ipomoeae Pes-Capraes fresh one or two.Be decocted in water for oral dose; Fresh leaf is decocted soup and is washed or smash juice and smear affected part.(2. going out " Fujian Chinese herbal medicine " below side)

5. control external hemorrhoid: Ipomoea pescaprae(L.) Sweet dries, charred medicinal herb with its property retained, grind into powder, add Red mercuric oxide (HgO), Borneolum Syntheticum is a little, cold boiled water is adjusted and is coated with.(" Fujian traditional herbal medicine ")

Radix Zornia Diphyllae:

[meridian distribution of property and flavor] sweet in the mouth, cool in nature; Spleen channel.

[function cures mainly] 1, " the SHENGCAO property of medicine is standby to be wanted ": pot wine relieving heat toxin, loose carbuncle.Control furuncle, also treating snakebite.

2, " book on Chinese herbal medicine asks former ": control toothache.

3, " south of the Five Ridges gather medicinal herbs record ": control scrofula.

1, control beriberi edema to ache: fresh Radix Zornia Diphyllae one two halves, pig's feet saves one and stewes clothes, serve on three, five times.(" Quanzhou book on Chinese herbal medicine ")

2, scrofula is controlled: Radix Zornia Diphyllae four liang, wine eight liang.Same decoction.(" south of the Five Ridges gather medicinal herbs record ")

3, disappear Serpentis skin ulcer, and reason snakebite: Radix Zornia Diphyllae, forges sustainability and mix it.(" book on Chinese herbal medicine asks former ")

4, control venom: fresh Radix Zornia Diphyllae or herb, smash for oral administration cuvette of strand juice, slag applies affected part, after six hours, then takes and applies.(" Quanzhou book on Chinese herbal medicine ")

Folium Stenolomatis:

[nature and flavor]: " Guangxi Chinese medicinal herbal ": micro-hardship, cold, nontoxic.

[function cures mainly]: effect of Folium Stenolomatis, heat clearing away, removing toxic substances, dampness removing, hemostasis.Control anemopyretic cold, heatstroke sun stroke, has loose bowels, dysentery, nebulousurine, leucorrhea, cough, spits blood, has blood in stool, hematuria, ulcerative gingivitis, carbuncle.

Radix berchemiae lineatae:

There is subduing swelling and detoxicating, hemostatic analgesia, the effects such as expelling wind and removing dampness

[meridian distribution of property and flavor] bitter in the mouth, micro-puckery, property is put down.GUIXIN, lung meridian.

[effect] subduing swelling and detoxicating; Hemostatic analgesia; Expelling wind and removing dampness.Cure mainly carbuncle furunculosis; Cough spitting of blood; Digestive tract hemorrhage; Traumatic injury; Scald; Rheumatic ostalgia; Acute toothache.

Radix Zanthoxyli:

Nature and flavor: arduous, temperature, slightly poisonous, there is numb feeling in the tongue.

Function cures mainly: dispelling wind and removing obstruction in the collateral, removing dampness to relieve pain, subduing swelling and detoxicating, main anemofrigid-damp arthralgia, bones and muscles pain, injury and bone fracture, colic, and laryngopharynx swelling and pain, has a stomach-ache, and ascarid Jue suffers from abdominal pain, toothache, and carbuncle sore scrofula is scalded.

Herba Asteris Ageratoidis:

Nature and flavor bitter in the mouth pungent cool in nature

Function cures mainly heat-clearing and toxic substances removing eliminating phlegm and relieving cough cooling blood for hemostasis cure mainly cold, fever tonsillitis bronchitis hepatitis dysentery pyretic stranguria heat in blood tells epistaxis carbuncle furunculosis snake bite and insect sting

Antibacterial and antivirus action decoct is to staphylococcus aureus micrococcus catarrhalis and Neisseria have certain inhibitory action external infected by influenza a type Jiangxi, Asia strains prosperous doctor 58-3 strain there is inhibitory action in vitro but in vivo embryo Gallus domesticus then without the phenol red method of mice proves contained Quercetin 0.4g/kg nimbecetin 0.3g/kg there is good phlegm-dispelling functions

Herba Galii Teneri:

[meridian distribution of property and flavor] toil, cold.

[function cures mainly] cures mainly carbuncletoxic swelling; Mastitis; Appendicitis; Edema; Cold, fever; Dysentery; Urinary tract infection; Hematuria; Gingival hemorrhage; Knife injury is hemorrhage.

Uroctea compatilis Koch.:

effect is classified:blood-cooling hemostatic

nature and flavor:salty in the mouth; Micro-hardship; Cool in nature

effect:heat-clearing and toxic substances removing; Arresting convulsion; Hemostasis.

Cure mainly: control scarlet fever, sore throat, tonsillitis is had a toothache, furuncle, wound hemorrhage, vomiting, cough.

Herba Androsaces Umbellatae (Herba Androsaces Coccineae): medicine name: Herba Androsaces umbellatae

Nature and flavor: bitter; Pungent; Cold nature

Gui Jing: lung meridian; Liver Channel; Spleen channel.

Function: heat-clearing and toxic substances removing; Reducing swelling and alleviating pain.

Cure mainly: laryngopharynx swelling and pain; Aphtha; Toothache; Headache; Acute conjunctivitis; Rheumatic arthralgia; Asthma; Stranguria with turbid discharge; Treat pyogenic infections from tumour or sore; Burn and scald; Venom; Traumatic injury.

Folium Salicis Babylonicae:

Heat-clearing and toxic substances removing, removing toxic substances rash, inducing diuresis for treating stranguria syndrome.Controlling acute diseases such as cholera and sunstroke rash sends out not smooth thoroughly, nebulousurine, furuncle furuncle and phyma, mastitis, and goiter, erysipelas, scalds, toothache.

Folium Blechni orientalis:

[nature and flavor] are bitter; Cold

[return through] liver Channel

[function cures mainly] heat-clearing and toxic substances removing.Main carbuncle furuncle

Rhizoma Coptidis:

[meridian distribution of property and flavor] is bitter, cold.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.

[function cures mainly] heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood tells nosebleed, conjunctival congestion, and toothache, quenches one's thirst, carbuncle furuncle; External treatment eczema, eczema, auditory meatus is suppurated.It is burning hot that Rhizoma Coptidis (processed with wine) is apt to the clear part of the body cavity above the diaphragm housing the heart and lungs.For conjunctival congestion, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach stomach function regulating preventing or arresting vomiting.Tie mutually for cold and heat, damp and hot middle resistance, feeling of fullness is vomitted.Cornel Rhizoma Coptidis soothing liver-QI stomach function regulating preventing or arresting vomiting.For incoordination between the liver and stomach, vomiting acid regurgitation.

Cortex Myricae Rubrae:

[nature and flavor] " Jiangxi traditional herbal medicine proved recipe ": warm in nature, bitter in the mouth is pungent puckery, nontoxic.

[function cures mainly] controls dysentery, traumatic injury, corneal nebula, toothache, burn, malignant boil mange.

Herba seu Flos Convolvuli arvensis:

[nature and flavor] are pungent; Temperature; Poisonous; Return kidney channel.

[function cures mainly] dispelling wind for relieving itching; Pain relieving.Main air pain of dampness syndrome; Toothache; Neurodermatitis.

Aster dubius (Thunb.) Onno:

[nature and flavor] are bitter, flat.

[function cures mainly] tonify deficiency is weak.Control consumptive disease wound, halitosis, gingival hemorrhage, vicious impetigo

Borneolum Syntheticum:

specific implementation method:

embodiment 1, formula:

Medicine for external use is formed by the raw material of Chinese medicine compatibility of following weight:

Alumen 10g, Borneolum Syntheticum 10g, mentha leave 10g, Pericarpium Zanthoxyli 10g, Cortex Garciniae 5g, Herba oxytropis glabrae 5g, Ipomoea pescaprae(L.) Sweet 5g, Radix Zornia Diphyllae 5g, Folium Stenolomatis 5g, Radix berchemiae lineatae 5g, Radix Zanthoxyli 5g;

The preparation method of medicine for external use:

Oral medicine is formed by the raw material of Chinese medicine compatibility of following weight:

Cortex Garciniae 10g, Herba oxytropis glabrae 10g, Ipomoea pescaprae(L.) Sweet 10g, Radix Zornia Diphyllae 10g, Folium Stenolomatis 10g, Radix berchemiae lineatae 10g, Radix Zanthoxyli 10g, Herba Asteris Ageratoidis 10g, Herba Galii Teneri 10g, Uroctea compatilis Koch. 15g, Herba Androsaces Umbellatae (Herba Androsaces Coccineae) 15g, Folium Salicis Babylonicae 15g, Folium Blechni orientalis 15g, Rhizoma Coptidis 15g, Cortex Myricae Rubrae 15g, Herba seu Flos Convolvuli arvensis 15g, Aster dubius (Thunb.) Onno 15g, Borneolum Syntheticum 15g;

Oral medicine preparation method:

Three times one time on the oral one three.

embodiment 2, formula:

Medicine for external use is made up of the raw material of Chinese medicine compatibility of following weight:

Alumen 12g, Borneolum Syntheticum 12g, mentha leave 12g, Pericarpium Zanthoxyli 12g, Cortex Garciniae 6g, Herba oxytropis glabrae 6g, Ipomoea pescaprae(L.) Sweet 6g, Radix Zornia Diphyllae 6g, Folium Stenolomatis 6g, Radix berchemiae lineatae 6g, Radix Zanthoxyli 6g;

Cortex Garciniae 12g, Herba oxytropis glabrae 12g, Ipomoea pescaprae(L.) Sweet 12g, Radix Zornia Diphyllae 12g, Folium Stenolomatis 12g, Radix berchemiae lineatae 12g, Radix Zanthoxyli 12g, Herba Asteris Ageratoidis 12g, Herba Galii Teneri 12g, Uroctea compatilis Koch. 16g, Herba Androsaces Umbellatae (Herba Androsaces Coccineae) 16g, Folium Salicis Babylonicae 16g, Folium Blechni orientalis 16g, Rhizoma Coptidis 16g, Cortex Myricae Rubrae 16g, Herba seu Flos Convolvuli arvensis 16g, Aster dubius (Thunb.) Onno 16g, Borneolum Syntheticum 16g.

Preparation method is identical with embodiment 1.

embodiment 3, formula:

Alumen 15g, Borneolum Syntheticum 15g, mentha leave 15g, Pericarpium Zanthoxyli 15g, Cortex Garciniae 8g, Herba oxytropis glabrae 8g, Ipomoea pescaprae(L.) Sweet 8g, Radix Zornia Diphyllae 8g, Folium Stenolomatis 8g, Radix berchemiae lineatae 8g, Radix Zanthoxyli 8g;

Cortex Garciniae 13g, Herba oxytropis glabrae 13g, Ipomoea pescaprae(L.) Sweet 13g, Radix Zornia Diphyllae 13g, Folium Stenolomatis 13g, Radix berchemiae lineatae 13g, Radix Zanthoxyli 13g, Herba Asteris Ageratoidis 13g, Herba Galii Teneri 13g, Uroctea compatilis Koch. 17g, Herba Androsaces Umbellatae (Herba Androsaces Coccineae) 17g, Folium Salicis Babylonicae 17g, Folium Blechni orientalis 17g, Rhizoma Coptidis 17g, Cortex Myricae Rubrae 17g, Herba seu Flos Convolvuli arvensis 17g, Aster dubius (Thunb.) Onno 17g, Borneolum Syntheticum 17g.

Preparation method is identical with embodiment 1.

embodiment 4, formula:

Alumen 18g, Borneolum Syntheticum 18g, mentha leave 18g, Pericarpium Zanthoxyli 18g, Cortex Garciniae 9g, Herba oxytropis glabrae 9g, Ipomoea pescaprae(L.) Sweet 9g, Radix Zornia Diphyllae 9g, Folium Stenolomatis 9g, Radix berchemiae lineatae 9g, Radix Zanthoxyli 9g;

Cortex Garciniae 14g, Herba oxytropis glabrae 14g, Ipomoea pescaprae(L.) Sweet 14g, Radix Zornia Diphyllae 14g, Folium Stenolomatis 14g, Radix berchemiae lineatae 14g, Radix Zanthoxyli 14g, Herba Asteris Ageratoidis 14g, Herba Galii Teneri 14g, Uroctea compatilis Koch. 18g, Herba Androsaces Umbellatae (Herba Androsaces Coccineae) 18g, Folium Salicis Babylonicae 18g, Folium Blechni orientalis 18g, Rhizoma Coptidis 18g, Cortex Myricae Rubrae 18g, Herba seu Flos Convolvuli arvensis 18g, Aster dubius (Thunb.) Onno 18g, Borneolum Syntheticum 18g.

Preparation method is identical with embodiment 1.

embodiment 5, formula:

Alumen 20g, Borneolum Syntheticum 20g, mentha leave 20g, Pericarpium Zanthoxyli 20g, Cortex Garciniae 10g, Herba oxytropis glabrae 10g, Ipomoea pescaprae(L.) Sweet 10g, Radix Zornia Diphyllae 10g, Folium Stenolomatis 10g, Radix berchemiae lineatae 10g, Radix Zanthoxyli 10g;

The preparation method of medicine for external use:

Cortex Garciniae 15g, Herba oxytropis glabrae 15g, Ipomoea pescaprae(L.) Sweet 15g, Radix Zornia Diphyllae 15g, Folium Stenolomatis 15g, Radix berchemiae lineatae 15g, Radix Zanthoxyli 15g, Herba Asteris Ageratoidis 15g, Herba Galii Teneri 15g, Uroctea compatilis Koch. 20g, Herba Androsaces Umbellatae (Herba Androsaces Coccineae) 20g, Folium Salicis Babylonicae 20g, Folium Blechni orientalis 20g, Rhizoma Coptidis 20g, Cortex Myricae Rubrae 20g, Herba seu Flos Convolvuli arvensis 20g, Aster dubius (Thunb.) Onno 20g, Borneolum Syntheticum 20g;

Oral medicine preparation method:

Three times one time on the oral one three.

Pharmacology pharmacodynamic is tested:

1, acute toxicity test

Application mice carries out acute toxicity testing and shows: Mouse oral gavage Chinese medicine preparation of the present invention, under 488.8g crude drug/kg dosage, after administration, mice occurs that light activity reduces, 1 hours recovers normal, Continuous Observation 7 days after administration, none animal dead, its overall health of patients, diet, take the photograph water, urine and body weight increase all normal, experimental result shows: the maximum dosage-feeding of Mouse oral gavage Traditional Chinese medicine preparation capsule agent of the present invention is 488.8g crude drug/kg/d (LD 50 > 488.8g crude drug/kg).Chinese medicine preparation clinical application every day total amount of the present invention is 0.1g crude drug/kg/d; By weighing machine, the dosis tolerata of mouse stomach Chinese medicine preparation of the present invention is 4888 times of clinical patient.Point out this medicine acute toxicity low, clinical drug safety.

2, long term toxicity test

Select SD rat, give the Chinese medicine preparation of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, within after last administration 24 hours, respectively group is alive kills 1/2 animal (male and female half and half), and all the other 1/2 animals continue observations 2 weeks rear living and kill.Duration of test observes outward appearance, general behavior, food ration, the body weight change of animal, within after administration 90 days, within 2 weeks, carries out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology with drug withdrawal.Result of the test shows: invention formulation is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all in normal range, without significant difference between group; Each group of main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, rat is had no significant effect in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days according to result of the test Chinese medicine preparation of the present invention, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the dose safety of Chinese medicine preparation clinical practice of the present invention higher.

3, animal local excitation test:

The allergic reaction on guinea pigs of invention formulation and Rat-rectum medication irritation test.Result shows: skin anaphylactic test, high dose group 0.8g (medicated powder)/kg, low dose group 0.1g (medicated powder)/kg, be equivalent to 20 times, 2.5 times that intend clinical people's consumption [0.04g (medicated powder)/kg] respectively, through percutaneous drug delivery, be showed no animal and produce allergy; Rectal application irritation test high dose group 5.0g (medicated powder)/kg, low dose group 3.2g (medicated powder)/kg, be equivalent to 125,80 times that intend clinical people's consumption respectively, mucous membrane of rectum is observed all without phenomenons such as hyperemia, edema in official hour, histopathologic examination compares no significant difference with blank group, have no and occur obvious irritative response, often organize its overall health of patients of Some Animals of retention, body weight, breathing, circulation, central nervous system and extremity are movable, equal Non Apparent Abnormality reaction.

treatment periodontal disease observation of curative effect:

The symptom of periodontitis, main manifestations is red swelling of gingiva, hemorrhage, not only hemorrhage when brushing teeth, sometimes also hemorrhage when speaking or sting hard object, even also can have spontaneous hemorrhage.Therefore, Bleeding control, recur to treatment primary disease be of great significance.We adopt the Chinese medicine preparation for the treatment of Asia inflammation in 2009-2011, and treatment periodontal disease 100 example, obtains good result, be now summarized as follows.

health giving quality observation index

Curative effect index: red swelling of gingiva, gingival hemorrhage, pyorrhea, halitosis, odontoseisis, elongation, displacement, pain,

Secondary efficacy index: stool, urine, picture of the tongue, pulse condition.

model case curative effect determinate standard:

Local disease damage evaluation criteria is as the criterion with gingiva healing and the scorching hot degree of pain.

Clinical recovery: medication is transference cure after 5 days, and sign disappears substantially, periodontitis disease damage all healed, leading indicator integration is 0 or 1.

Effective: medication is transference cure after 1 day, and sign all has clear improvement, periodontal disease healing reaches 2/3 or hemorrhagely to reduce, and leading indicator integration is 1, two is 2.

Effective: medication is transference cure after 1 day, and sign all take a favorable turn, periodontitis healing reaches 1/3 or hemorrhagely to reduce, and leading indicator integration is 2, two is 3.

Invalid: medication cardinal symptom after 3 days, sign are improved not obvious, and Asia inflammation is substantially unchanged, and leading indicator integration is 3 or 4.

therapeutic outcome is in Table

Age	Recovery from illness	Effective	Invalid	Effective percentage (%)
					Less than 10 years old	20	20	---	100％
10-35 year	40	40	---	100％
					35-55 year	36	25	4	96.6％
More than 55 years old	4	3	1	99％

In sum: recovery from illness clinical improvements rate >=95%; Effective clinical improvements rate < 95%, >=60%;

Invalid clinical improvements rate < 10%.

Claims

1. treat a Chinese medicine preparation for periodontitis, it is characterized in that: comprise medicine for external use and oral medicine, wherein medicine for external use is made up of the raw material of Chinese medicine compatibility of following weight portion:

Cortex Garciniae 10-15 part, Herba oxytropis glabrae 10-15 part, Ipomoea pescaprae(L.) Sweet 10-15 part, Radix Zornia Diphyllae 10-15 part, Folium Stenolomatis 10-15 part, Radix berchemiae lineatae 10-15 part, Radix Zanthoxyli 10-15 part, Herba Asteris Ageratoidis 10-15 part, Herba Galii Teneri 10-15 part, Uroctea compatilis Koch. 15-20 part, Herba Androsaces Umbellatae (Herba Androsaces Coccineae) 15-20 part, Folium Salicis Babylonicae 15-20 part, Folium Blechni orientalis 15-20 part, Rhizoma Coptidis 15-20 part, Cortex Myricae Rubrae 15-20 part, Herba seu Flos Convolvuli arvensis 15-20 part, Aster dubius (Thunb.) Onno 15-20 part, Borneolum Syntheticum 15-20 part.

2. a kind of Chinese medicine preparation for the treatment of periodontitis according to claim 1, is characterized in that: comprise medicine for external use and oral medicine, and wherein medicine for external use is made up of the raw material of Chinese medicine compatibility of following weight portion:

3. a kind of Chinese medicine preparation for the treatment of periodontitis according to claim 1, is characterized in that: comprise medicine for external use and oral medicine, and wherein medicine for external use is made up of the raw material of Chinese medicine compatibility of following weight portion:

4. a kind of Chinese medicine preparation for the treatment of periodontitis according to claim 1-3 any one, is characterized in that: comprise medicine for external use and oral medicine, wherein the preparation method of medicine for external use:

Oral medicine preparation method: