CN103341151B - Traditional Chinese medicine for treating chronic bronchitis - Google Patents

Traditional Chinese medicine for treating chronic bronchitis Download PDF

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CN103341151B
CN103341151B CN201310326410.0A CN201310326410A CN103341151B CN 103341151 B CN103341151 B CN 103341151B CN 201310326410 A CN201310326410 A CN 201310326410A CN 103341151 B CN103341151 B CN 103341151B
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chinese medicine
semen
decoct
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CN103341151A (en
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李红霞
李爱华
刘霞
周艳珍
程英
常艳
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Abstract

The invention provides a traditional Chinese medicine for treating chronic bronchitis. The traditional Chinese medicine comprises the following active pharmaceutical ingredients: white mustard seed, membranous milkvetch root, bitter apricot seed, cassia twig, honeysuckle flower, inula flower, manchurian wildginger, Chinese date, saffron, cattail pollen, amur corktree bark, radish seed, mulberry leaf, common macrocarpium fruit, coix seed, immature bitter orange, tangerine peel, dried ginger and rubus corchorifolius leaf. Compared with western medicine treatment, the traditional Chinese medicine can be used for treatment on the whole, and has the advantages of no toxicity, no side effect, no medicament resistance, good effect and no recurrence of diseases.

Description

Be used for the treatment of the Chinese medicine of chronic bronchitis
Technical field
The present invention relates to technical field of Chinese medicine, particularly relate to a kind of Chinese medicine being used for the treatment of chronic bronchitis.
Background technology
Chronic bronchitis is by infecting or the chronic nonspecific inflammation of trachea-bronchial epithelial cell mucosa that non-infective agent causes and surrounding tissue, is common clinical, frequently-occurring disease.Be apt to occur in winter and spring, recurrent exerbation, touching difficulty more.
Society tobacco and wine culture prevailing, for the doings of people provide auxiliary element, but also bring threat for the healthy of people, tobacco and wine are also one of factors of bringing out chronic bronchitis simultaneously.Life stress causes work fatigue, and overtired is also one of reason of bringing out this disease, and courses of infection, virus, irritative gas, cold weather etc. all can cause bronchial mucosa impaired in addition, bring out the generation of chronic bronchitis diseases.
This disease is clinical in cough, companion's expectoration, pants for feature, can concurrent obstructive emphysema even pulmonary heart disease time serious, causes patient respiratory difficulty or heart failure.Any ages crowd all can fall ill, be more common in middle-aged and elderly people, according to interrelated data display, the sickness rate of China's more than 50 years old crowd's chronic bronchitis is about 15%, day by day increasing the weight of in recent years along with aged tendency of population and environmental pollution, its sickness rate is more and more higher.Patient has allergies, prolonged and repeated virus and bacteriological infection, and immunity of organisms reduces and some chemical factors etc. can bring out primary disease, with multiple when cold season autumn and winter or temperature cataclysm.Patient Chang Yin recurrent exerbation, protracted course of disease, the course of disease are long and Multiple Hospitalization is treated, and not only can have a strong impact on the quality of life of patient, and can increase the burden of patient home and society.
Western medical treatment all selects antiinflammatory, apophlegmatisant, generally uses antibiotic therapy, and symptom can be alleviated, but cough, expectoration easily recurs, and side effect is more.Treatment easily produces drug resistance to antibiotic and antiviral drugs repeatedly, causes curative effect to decline.Western medical treatment biases toward anti symptom treatment more, for recurrent exerbation patient, is often difficult to obtain good effect.
Chronic bronchitis patient has cough, white, the uncomfortable in chest asthma of expectorant more and meets the heavy performance of cold rnning, the many genus of Chinese medical discrimination are suffered from a deficiency of the kidney and are not received, stagnation of phlegm-damp, therefore with " organic conception " " treatment must aim at the pathogenesis of disease " " treating both the principal and secondary aspects of a disease " for Therapeutic Principle, there is the advantage that western medical treatment does not have.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of Chinese medicine being used for the treatment of chronic bronchitis,
Relative to western medical treatment, it can be treated on the whole, has no side effect and drug resistance, respond well, and the state of an illness is not repeatedly.
Accordingly, the invention provides a kind of Chinese medicine being used for the treatment of chronic bronchitis, its crude drug comprises:
Semen Sinapis Albae, the Radix Astragali, Semen Armeniacae Amarum, Ramulus Cinnamomi, Flos Lonicerae, Flos Inulae, Herba Asari, Fructus Jujubae, Stigma Croci, Pollen Typhae, Cortex Phellodendri, Semen Raphani, Folium Mori, Fructus Corni, Semen Coicis, Fructus Aurantii Immaturus, Pericarpium Citri Reticulatae, Rhizoma Zingiberis and compound in rubus corchorifolius leaf.
Wherein, described Chinese medicine is only made up of above-mentioned raw materials medicine component.
Wherein, in described Chinese medicine, the weight portion of each crude drug is respectively Semen Sinapis Albae 22 ~ 28 weight portion, the Radix Astragali 41 ~ 53 weight portion, Semen Armeniacae Amarum 27 ~ 35 weight portion, Ramulus Cinnamomi 37 ~ 46 weight portion, Flos Lonicerae 18 ~ 26 weight portion, Flos Inulae 12 ~ 19 weight portion, Herba Asari 19 ~ 25 weight portion, Fructus Jujubae 27 ~ 33 weight portion, Stigma Croci 21 ~ 28 weight portion, Pollen Typhae 18 ~ 23 weight portion, Cortex Phellodendri 30 ~ 40 weight portion, Semen Raphani 32 ~ 37 weight portion, Folium Mori 22 ~ 29 weight portion, Fructus Corni 35 ~ 41 weight portion, Semen Coicis 20 ~ 29 weight portion, Fructus Aurantii Immaturus 30 ~ 36 weight portion, Pericarpium Citri Reticulatae 26 ~ 30 weight portion, Rhizoma Zingiberis 27 ~ 33 weight portion and compound in rubus corchorifolius leaf 15 ~ 23 weight portion.
Wherein, in described Chinese medicine, the weight portion of each crude drug is respectively Semen Sinapis Albae 26 weight portion, the Radix Astragali 46 weight portion, Semen Armeniacae Amarum 31 weight portion, Ramulus Cinnamomi 41 weight portion, Flos Lonicerae 22 weight portion, Flos Inulae 16 weight portion, Herba Asari 22 weight portion, Fructus Jujubae 30 weight portion, Stigma Croci 25 weight portion, Pollen Typhae 20 weight portion, Cortex Phellodendri 35 weight portion, Semen Raphani 35 weight portion, Folium Mori 26 weight portion, Fructus Corni 38 weight portion, Semen Coicis 25 weight portion, Fructus Aurantii Immaturus 33 weight portion, Pericarpium Citri Reticulatae 29 weight portion, Rhizoma Zingiberis 30 weight portion and compound in rubus corchorifolius leaf 20 weight portion.
Wherein, described Chinese medicine can be prepared into syrup and granule.
The preparation method of Chinese medicine provided by the invention, when the dosage form of described Chinese medicine is granule, is specially:
Above-mentioned raw materials medicine component is mixed in proportion, decoct with water twice, add for 1st time relative to mixture quality 6 ~ 8 times of water gagings, decoct 2 hours, add for 2nd time relative to mixture quality 4 ~ 6 times of water gagings, decoct 1 hour, filter, merging filtrate, be concentrated into every 1ml about containing the clear paste of 1g medical material, adding hydrochloric acid adjusts pH to be 1, limit edged stirs, leave standstill, with siphonage sucking-off supernatant, precipitate sucking filtration is to dry, wash with water to nothing obviously acid, take out drying precipitate, pulverize, obtain dry powder, add relative to dry powder quality 20% ~ 30% cane sugar powder (mass percent) subsequently, be 75% ~ 85% ethanol soft material with determining alcohol, granulate with oscillating granulator, dry at 60 DEG C, granulate, obtain granule.
The preparation method of Chinese medicine provided by the invention, when the dosage form of described Chinese medicine is syrup, is specially:
Above-mentioned raw materials medicine component is mixed in proportion, decoct with water twice, add for 1st time relative to mixture quality 6 ~ 8 times of water gagings, decoct 2 hours, add for 2nd time relative to mixture quality 4 ~ 6 times of water gagings, decoct 1 hour, filter, merging filtrate, be concentrated into every 1ml about containing the clear paste of 1g medical material, adding hydrochloric acid adjusts pH to be 1, limit edged stirs, leave standstill, with siphonage sucking-off supernatant, precipitate sucking filtration is to dry, wash with water to nothing obviously acid, take out drying precipitate, pulverize, obtain dry powder, get 100 weight portion dry powder, 3 weight portion ~ 5 weight portion sodium carboxymethyl cellulose, the sucrose of 30 weight portion ~ 50 weight portions, the sodium benzoate of 0.5 weight portion ~ 1 weight portion is dispersed in water, stirring and evenly mixing, obtaining crude drug concentration is the solution of 3g/ml ~ 5g/ml, boil and make dissolving, filter, subpackage after sterilizing, obtain syrup.
Beneficial effect of the present invention:
Chinese medicine provided by the invention is in treatment chronic bronchitis, and relative to western medical treatment, it can be treated on the whole, has no side effect and drug resistance, respond well, and the state of an illness is not repeatedly.
Detailed description of the invention
Motherland's medical science thinks that chronic tracheitis belongs to the category such as " cough ", " phlegm retention ", " the syndrome of dyspnea ", and how because of the heresy of diseases caused by exogenous pathogenic factor six climate exopathogens, because the course of disease is longer, latent phlegm hinders in lung, injures lungs, and pathogenesis is that yang deficiency is drunk and stopped,
The cough that chronic bronchitis patient is permanent, outbreak often and repeatedly, cause disease and spleen kidney,
Thus make spleen-kidney vacuity cold, old complaint and disease originally do not reach firmly, purplish tongue or light, arteries and veins many and heavy thin, tongue is white.During lung kidney in the morbidity of chronic bronchitis and body is insufficiency of the spleen etc., the deficiency of healthy energy and exopathogen invade relation.The cardinal symptom of chronic bronchitis shows as repeatedly coughs up phlegm, coughs, and the basis of its cause of disease is mainly the interior volt of phlegm retention and the imbalance of internal organs.
The total pathogenesis of this disease is because diseases caused by exogenous pathogenic factor six evil causes impairment of purifying and descending function of the lung, and cough, expectorant, breathe heavily all diseases and in succession occur, with the passing of time injure spleen kidney, it is marked on lung, and it is at spleen kidney.Have Exogenous and internal injuries point, diseases caused by exogenous pathogenic factor person attacks for six climate exopathogens are taken advantage of, and internal injury is many injures spleen kidney because of prolonged illness.Qing Dynasty Shen Jin huge legendary turtle is pointed out in " miscellaneous diseases source and course rhinoceros candle cough, asthma source and course ": " lid lung is not hindered and do not coughed, and spleen does not hinder not chronic cough, and it is not vehement that kidney does not hinder fire, coughs not very, and it greatly more also." illustrate lung spleen kidney three dirty be the major lesions place of cough, spleen insufficiency water liquid, accumulation and obstruction of sputum, causes impairment of dispersing and descending function of the lung, abnormal rising of lung-QI and falling ill.Suffer from a deficiency of the kidney and not improving inspiration by invigorating kidney-QI frequently do to panting.
Therefore, primary disease treatment should be main with " invigorating the spleen and benefiting QI the kidney invigorating, relieving cough and resolving phlegm is relievingd asthma ".
Accordingly, the invention provides a kind of Chinese medicine being used for the treatment of chronic bronchitis, its crude drug comprises:
Semen Sinapis Albae, the Radix Astragali, Semen Armeniacae Amarum, Ramulus Cinnamomi, Flos Lonicerae, Flos Inulae, Herba Asari, Fructus Jujubae, Stigma Croci, Pollen Typhae, Cortex Phellodendri, Semen Raphani, Folium Mori, Fructus Corni, Semen Coicis, Fructus Aurantii Immaturus, Pericarpium Citri Reticulatae, Rhizoma Zingiberis and compound in rubus corchorifolius leaf.
Fang Zhong, Semen Sinapis Albae has the use of warming the lung eliminating phlegm promoting the circulation of QI, the Radix Astragali, return liver spleen kidney three warp, there is the effect of benefiting QI for strengthening the superficies, Semen Armeniacae Amarum relieving the exterior syndrome by diaphoresis, depressed lung-energy dispersing, it can control the maincenter of coughing, Ramulus Cinnamomi warming yang for resolving fluid retention, Flos Lonicerae has good antibacterial, antiviral efficacy, the acute lung injury of endotaxin induction can also be suppressed, to the treatment of chronic bronchitis, there is help, Flos Inulae can be alleviated bronchial spasm thus relieving asthma, Herba Asari, Stigma Croci contains reduction bronchial secretion and antianaphylactic spasmolysis, Fructus Jujubae can increase its hemoglobin, and the regeneration of hemocyte can be promoted, Pollen Typhae has microthrombus in reasonable removing diseased region and antianaphylactic effect unique, Cortex Phellodendri is good at part of the body cavity above the diaphragm housing the heart and lungs lung-fire clearly, expectorant promoting the circulation of QI Dingchuan is coughed, Semen Raphani energy lowering the adverse-rising QI to resolve phlegm, relieving cough and asthma, You Yizhi cough expectorant is stopped up, Folium Mori have dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, effect of clearing away lung-heat to relieve cough, Fructus Corni, Galla Chinensis the kidney warming improving inspiration by invigorating kidney-QI, relieving cough and asthma, Semen Coicis is strong turns round and look at taste, exhausted the source of producing phlegm, Fructus Aurantii Immaturus can stimulate throat mucosa, reflexive causes respiratory mucosa hypersecretion, there is obvious phlegm-dispelling functions, Pericarpium Citri Reticulatae has peace stomach of regulating the flow of vital energy, the effect of drying dampness to eliminate phlegm, Rhizoma Zingiberis warming spleen and stomach for dispelling cold, warming the lung to resolve fluid-retention, compound in rubus corchorifolius leaf relieving sore-throat by clearing away heat, removing toxic substances sore, all medicines share, realize invigorating the spleen and benefiting QI the kidney invigorating, the treatment that relieving cough and resolving phlegm is relievingd asthma.
Each crude drug pharmacology is as follows:
Semen Sinapis Albae: the dry mature seed of crucifer Caulis et Folium Sinapis albee, latin name sinapis Semen, acrid in the mouth, hot in nature, have warming the lung eliminating phlegm promoting the circulation of QI, effect of resolving mass and removing the obstruction of the collateral pain relieving, breathes with cough for cold-phlegm, distending pain in the chest and hypochondrium, the stagnant meridians of expectorant, joint numbness, pain, phlegm-damp oozing in the body, the cards such as carbuncle of yin nature toxic swelling.
The Radix Astragali: sweet in the mouth, warm in nature, enter spleen, lung meridian, have tonification spleen soil, elevate a turnable ladder yang-energy, strengthening superficial resistance to stop perspiration, the effects such as holder skin ulcer granulation promoting, are mainly used in the weak anorexia and loose stool that deficiency of both the splenic and pulmonary QI is caused, shortness of breath and palpitation, the visceroptosis of sinking of QI of middle-JIAO, the metrorrhagia of QI failing to control blood is had blood in stool, chronic diarrhea proctoptosis; The spontaneous sweating of exterior deficiency, the cards such as insufficiency of vital energy and blood.
Semen Armeniacae Amarum: bitter in the mouth, pungent, slightly warm in nature, enters spleen, lung two warp, there is lung qi dispersing cough-relieving, lowering the adverse-rising QI to subdue asthma, loosening bowel to relieve constipation, effect of parasite killing removing toxic substances, cures mainly cough, dyspnea with rapid and short breath fullness in the chest, sore throat pharyngalgia, dryness of the intestine constipation, the cards such as insect poison skin infection, Compendium of Material Medica: earnestly Semen Armeniacae Amarum can fall apart and can fall, therefore expelling pathogenic factors from muscles, loose wind, sending down the abnormal ascending QI, moisturize, removing food stagnancy, cure the wound to damage in medicine and use it.Control skin ulcer parasite killing, with its poison also.Control in wind and cold pectoral, also have gross weight point user, get it and disperse also.
Ramulus Cinnamomi: acrid in the mouth, sweet, warm in nature, GUIXIN, lung, urinary bladder channel, have diaphoresis expelling pathogenic factors from muscles, warming the meridian and promoting blood circulation, supporing yang activating QI, the effect of dispersing cold for relieving pain, Ramulus Cinnamomi warming the meridian and promoting blood circulation, horizontal logical podomere, for affection of exogenous wind-cold exterior syndrome, no matter have antiperspirant, losslessly all can to apply, also for rheumatic arthralgia, cold syndrome of the stomach stomachache, amenorrhea, dysmenorrhea, rheumatic arthralgia, the cards such as shoulder arm podomere cold type of pain, phlegm retention syndrome and bladder water-retention, heart deficiency of spleen-YANG, retention of water-damp in the body, fullness and distention in the chest and hypochondrium, cough with dyspnea dizziness waits phlegm retention syndrome.
Flos Lonicerae: sweet in the mouth, cold in nature, enters the heart, lung, stomach, large intestine channel, has the effect of heat-clearing and toxic substances removing, and holding concurrently can eliminating pathogenic heat from blood to cure dysentery.Be mainly used in affection due to external wind and heat, epidemic febrile disease pyretic toxicity is comparatively contained, or when epidemic febrile disease is still not descending at the part of the body cavity above the diaphragm housing the heart and lungs from the beginning of pathogenic heat; Pyretic toxicity dysentery, stool hematochezia; Fever disease in summer is demonstrate,proved; The carbuncle sore that pyretic toxicity gathers is from the beginning of the, inflammation heat person of swelling and ache etc., Flos Lonicerae has good antipyretic effect, energy antiinflammatory, what control inflammation oozes out and inflammatory hyperplasia, can leukocytic phagocytic function be promoted, have stronger bacteriostasis to multiple pyococcus and pathogenic entero becteria, comprise staphylococcus, Hemolytic streptococcus, meningococcus, dysentery bacterium, Bacillus typhi, bacillus pyocyaneus, tubercule bacillus etc., the pyretic toxicity that Flos Lonicerae is divided QI and blood battalion is all effective, and has broad-spectrum antibacterial action.
Flos Inulae: the first system of its taste with salty, relaxing the bowels with lubricant drugs is done salty, salty energy softening the hard mass; " not Lu " to sweet taste in the mouth, in Gan Nenghuan; Tepor, temperature can be passed through, therefore main stagnation of QI fullness in the hypochondrium; Heart spleen latent fluid-retention is sick palpitation with fear then, and drink disappears then multiple normal.Dewater, remove cold and heat between the five internal organs, and expectorant knot on the breast that disappears, saliva is as shellac varnish, and heart side of body expectorant water, wing is prolonged fluid-retention all of a sudden, pathogenic wind arthralgia chiefly caused by damp pathogen, and between skin, dead flesh, opens in order, sharp large intestine person, and all softening the hard mass, cold profit, relaxing the bowels with lubricant drugs, expectorant drink the merit that dewaters also.It says invigorating middle warmer therapeutic method to keep the adverse QI flowing downwards person, in slow with sweet energy, salty can relaxing the bowels with lubricant drugs therefore also.Promoting blood circulation, beneficial color and luster person, lid refers to that the drink then spleen that disappears is good for, strong then can run, and spleen is wrapped up in blood and to be united again blood therefore also.
Herba Asari: latin name asari Radix et Rhizoma, acrid in the mouth, warm in nature, return lung, kidney channel, there is expelling wind and cold pain relieving, effect that warming the lung to resolve fluid-retention is sensible, cure mainly affection of exogenous wind-cold, headache, toothache, wind and cold temperature numbness, affection of exogenous wind-cold, in stop lung cold cough with asthma caused by cold fluid-retention, nasal obstruction nasal sinusitis, wind-eye corneal nebula, deafness pharyngalgia, the cards such as aphtha halitosis, Herba Asari has obvious inhibitory action to cellular immunization and humoral immunization.
Fructus Jujubae: sweet in the mouth, slightly warm in nature, have invigorating the spleen and replenishing QI, effect of nourishing blood to tranquillize the mind, returns spleen, stomach warp, cures mainly weakness of the spleen and stomach, deficiency of QI in middle-JIAO, fatigue and lack of strength, anorexia and loose stool; Blood deficiency fistula is yellow, become thin, or women is dirty dry, and spirit is uneasy waits card.
Stigma Croci: sweet in the mouth, property is put down, energy blood circulation promoting and blood stasis dispelling, dispersing stagnation and relieving accumulation of pathogens, pain relieving.Be used for the treatment of troubled thoughts pent-up, chest and diaphragm painful abdominal mass is vexed, and spit blood, typhoid fever is gone mad, and frightened fear in a trance, women's amenorrhea, stasis menoxenia, prolonged lochia, blood stasis is had a pain, measles, the cards such as traumatic injury.
Pollen Typhae: sweet in the mouth, property is put down, and enters liver, pericardium channel, has hemostasis, blood stasis dispelling, treating stranguria effect.For spitting blood, epistaxis, spitting of blood, metrorrhagia, traumatic hemorrhage, amenorrhea dysmenorrhea, gastral cavity ventral spine pain, tumbling and swelling, the cards such as blood strangury and dry pain.
Cortex Phellodendri: latin name phellodendri Chinensis Cortex,bitter in the mouth, cold in nature, enter kidney, bladder, large intestine channel, heat clearing and damp drying, eliminating fire and detoxication, except hectic fever due to YIN-deficiency clearind deficient heat.For damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity is warded off, hectic fever due to YIN-deficiency consumptive fever, night sweat, and seminal emission, sore swollen toxin, the cards such as eczema pruritus, Cortex Phellodendri has good antibacterial action to multiple gram-positive bacterium.
Semen Raphani: property is put down, acrid in the mouth, sweet, returns lung, spleen, stomach warp, has the de-swelling that helps digestion, effect of lowering the adverse-rising QI to resolve phlegm, cures mainly retention of food and drink, abdominal distention, constipation, stagnant dysentery, expectorant stops up cards such as breathing with cough.
Folium Mori: sweet in the mouth are bitter; Cold in nature.Return lung, Liver Channel, there is dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, suppressing liver-YANG, liver heat removing and eyesight improving, the effect of cooling blood for hemostasis, for anemopyretic cold and conjunctival congestion and swelling pain, wind-fire order disease, the few expectorant of dryness-heat impairing the lung, dry cough, " Bencao Jingshu ": " herbal classic " odorlessness.It cures mainly in detail, should be that sweet in the mouth gas is cold nontoxic.Sweet so beneficial blood, cold so removing heat from blood, to be sweetly coldly harmonious, therefore the therapeutic method to keep the adverse QI flowing downwards and tonifying YIN.With the main deficiency of YIN cold and heat of energy, and because of interior-heat perspiration.Its property is held concurrently dry, therefore can remove beriberi edema, sharp intestine and small intestine again.The golden gas of former official report, therefore can wind be removed again.Then to get both the respectful clearly of the world through frost, therefore again can improving eyesight and quenching the thirst.Originator, the leeway of blood, beneficial blood therefore again can long hair, removing heat from blood therefore emesis blood again.Close carbuncle mouth, the palm worn by net for catching birds or fish, and treat soup fire, all refrigerant merit of enriching blood also.
Fructus Corni: sour in the mouth, puckery, slightly warm in nature, returns liver, kidney channel, has liver and kidney tonifying, effect of essence astringing and desertion stemming.For vertigo and tinnitus, soreness of waist and knee joint, impotence and seminal emission, enuresis frequent micturition, bleeding not during menses, profuse sweating is collapsed.Interior-heat such as to be quenched one's thirst at the card.
Semen Coicis: cool in nature, sweet in the mouth, light, return spleen, stomach, lung meridian.Have the function of spleen invigorating eliminating dampness by diuresis, clearing away heat and discharging pus, eliminating impediment, diuretic, for weakness of the spleen and stomach, suffer from diarrhoea in loose stool, or vaginal discharge diseases of women, insufficiency of the spleen leading to overabundance of dampness edema, dysuria, or beriberi swells and ache; Damp and hot arthralgia pain, contracture of the limbs, miserable pain; Lung abscess cough and spit purulent sputum, or enterodynia contracture stomachache.
Fructus Aurantii Immaturus: bitter in the mouth, pungent, cold nature, enters spleen, stomach warp, has dispelling the stagnated QI removing food stagnancy, expectorant except the effect of painful abdominal mass, be mainly used in stagnant in stop, the YangmingFushi syndrome of distension and fullness in the abdomen, constipation.
Pericarpium Citri Reticulatae: warm in nature, acrid in the mouth, hardship; Return spleen, lung meridian, pungent loose logical temperature, fragrant odour, is longer than and regulates the flow of vital energy, and can enter spleen lung, therefore can go loose sluggishness of lung-QI, again can promoting the circulation of QI to alleviate the stagnation in middle-JIAO, gathers around stagnant, chest and diaphragm feeling of fullness and the card such as stagnation of QI in spleen and stomach, distension and fullness in the abdomen for lung qi.
Rhizoma Zingiberis: acrid in the mouth, hot in nature, return spleen, stomach, the heart, lung meridian; Have warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, dampness expectorant, effect of warming the lung to resolve fluid-retention, and for coldness and pain in the epigastrium, vomiting, has loose bowels, the cards such as YANG-depletion is fainted inverse, and cold fluid-retention is breathed with cough, arthralgia due to cold-dampnes.
Compound in rubus corchorifolius leaf: bitter in the mouth, puckery, property is put down, and has relieving sore-throat by clearing away heat, and effect of removing toxic substances sore, cures mainly laryngopharynx swelling and pain, carbuncle sore furuncle and phyma, mastitis, the cards such as eczema.
Preferably, described Chinese medicine is only made up of above-mentioned raw materials medicine component.
In described Chinese medicine, the weight portion of each crude drug is respectively Semen Sinapis Albae 22 ~ 28 weight portion, the Radix Astragali 41 ~ 53 weight portion, Semen Armeniacae Amarum 27 ~ 35 weight portion, Ramulus Cinnamomi 37 ~ 46 weight portion, Flos Lonicerae 18 ~ 26 weight portion, Flos Inulae 12 ~ 19 weight portion, Herba Asari 19 ~ 25 weight portion, Fructus Jujubae 27 ~ 33 weight portion, Stigma Croci 21 ~ 28 weight portion, Pollen Typhae 18 ~ 23 weight portion, Cortex Phellodendri 30 ~ 40 weight portion, Semen Raphani 32 ~ 37 weight portion, Folium Mori 22 ~ 29 weight portion, Fructus Corni 35 ~ 41 weight portion, Semen Coicis 20 ~ 29 weight portion, Fructus Aurantii Immaturus 30 ~ 36 weight portion, Pericarpium Citri Reticulatae 26 ~ 30 weight portion, Rhizoma Zingiberis 27 ~ 33 weight portion and compound in rubus corchorifolius leaf 15 ~ 23 weight portion.
Further preferably, in described Chinese medicine, the weight portion of each crude drug is respectively Semen Sinapis Albae 26 weight portion, the Radix Astragali 46 weight portion, Semen Armeniacae Amarum 31 weight portion, Ramulus Cinnamomi 41 weight portion, Flos Lonicerae 22 weight portion, Flos Inulae 16 weight portion, Herba Asari 22 weight portion, Fructus Jujubae 30 weight portion, Stigma Croci 25 weight portion, Pollen Typhae 20 weight portion, Cortex Phellodendri 35 weight portion, Semen Raphani 35 weight portion, Folium Mori 26 weight portion, Fructus Corni 38 weight portion, Semen Coicis 25 weight portion, Fructus Aurantii Immaturus 33 weight portion, Pericarpium Citri Reticulatae 29 weight portion, Rhizoma Zingiberis 30 weight portion and compound in rubus corchorifolius leaf 20 weight portion.
The Chinese medicine being used for the treatment of chronic bronchitis provided by the invention can be prepared into any regular dosage form, is preferably prepared into syrup and granule.
The preparation method of Chinese medicine provided by the invention, when the dosage form of described Chinese medicine is granule, is specially:
Above-mentioned raw materials medicine component is mixed in proportion, decoct with water twice, add for 1st time relative to mixture quality 6 ~ 8 times of water gagings, decoct 2 hours, add for 2nd time relative to mixture quality 4 ~ 6 times of water gagings, decoct 1 hour, filter, merging filtrate, be concentrated into every 1ml about containing the clear paste of 1g medical material, adding hydrochloric acid adjusts pH to be 1, limit edged stirs, leave standstill, with siphonage sucking-off supernatant, precipitate sucking filtration is to dry, wash with water to nothing obviously acid, take out drying precipitate, pulverize, obtain dry powder, add relative to dry powder quality 20% ~ 30% cane sugar powder (mass percent) subsequently, be 75% ~ 85% ethanol soft material with determining alcohol, granulate with oscillating granulator, dry at 60 DEG C, granulate, obtain granule.
The preparation method of Chinese medicine provided by the invention, when the dosage form of described Chinese medicine is syrup, is specially:
Above-mentioned raw materials medicine component is mixed in proportion, decoct with water twice, add for 1st time relative to mixture quality 6 ~ 8 times of water gagings, decoct 2 hours, add for 2nd time relative to mixture quality 4 ~ 6 times of water gagings, decoct 1 hour, filter, merging filtrate, be concentrated into every 1ml about containing the clear paste of 1g medical material, adding hydrochloric acid adjusts pH to be 1, limit edged stirs, leave standstill, with siphonage sucking-off supernatant, precipitate sucking filtration is to dry, wash with water to nothing obviously acid, take out drying precipitate, pulverize, obtain dry powder, get 100 weight portion dry powder, 3 weight portion ~ 5 weight portion sodium carboxymethyl cellulose, the sucrose of 30 weight portion ~ 50 weight portions, the sodium benzoate of 0.5 weight portion ~ 1 weight portion is dispersed in water, stirring and evenly mixing, obtaining crude drug concentration is the solution of 3g/ml ~ 5g/ml, boil and make dissolving, filter, subpackage after sterilizing, obtain syrup.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1
By Semen Sinapis Albae 26g, Radix Astragali 46g, Semen Armeniacae Amarum 31g, Ramulus Cinnamomi 41g, Flos Lonicerae 22g, Flos Inulae 16g, Herba Asari 22g, Fructus Jujubae 30g, Stigma Croci 25g, Pollen Typhae 20g, Cortex Phellodendri 35g, Semen Raphani 35g, Folium Mori 26g, Fructus Corni 38g, Semen Coicis 25g, Fructus Aurantii Immaturus 33g, Pericarpium Citri Reticulatae 29g, Rhizoma Zingiberis 30g and compound in rubus corchorifolius leaf 20g mixes, and decocts with water twice, adds for the 1st time relative to mixture quality 8 times of water gagings, decocts 2 hours, add for 2nd time relative to mixture quality 6 times of water gagings, decoct 1 hour, filter, merging filtrate, is concentrated into every 1ml about containing the clear paste of 1g medical material, adds hydrochloric acid and adjusts pH to be 1, limit edged stirs, and leaves standstill, with siphonage sucking-off supernatant, precipitate sucking filtration, to dry, wash with water to without obviously acid, takes out drying precipitate, pulverize, obtain dry powder, get 100g dry powder, 4g sodium carboxymethyl cellulose, the sucrose of 50g, the sodium benzoate of 0.5g is dispersed in water, stirring and evenly mixing, and obtaining crude drug concentration is the solution of 4g/ml, boils and makes dissolving, and filter, subpackage after sterilizing, obtains syrup.
Embodiment 2
By Semen Sinapis Albae 22g, Radix Astragali 41g, Semen Armeniacae Amarum 27g, Ramulus Cinnamomi 37g, Flos Lonicerae 18g, Flos Inulae 12g, Herba Asari 19g, Fructus Jujubae 27g, Stigma Croci 21g, Pollen Typhae 18g, Cortex Phellodendri 30g, Semen Raphani 32g, Folium Mori 22g, Fructus Corni 35g, Semen Coicis 20g, Fructus Aurantii Immaturus 30g, Pericarpium Citri Reticulatae 26g, Rhizoma Zingiberis 27g and compound in rubus corchorifolius leaf 15g mixes, and decocts with water twice, adds for the 1st time relative to mixture quality 8 times of water gagings, decocts 2 hours, add for 2nd time relative to mixture quality 6 times of water gagings, decoct 1 hour, filter, merging filtrate, is concentrated into every 1ml about containing the clear paste of 1g medical material, adds hydrochloric acid and adjusts pH to be 1, limit edged stirs, and leaves standstill, with siphonage sucking-off supernatant, precipitate sucking filtration, to dry, wash with water to without obviously acid, takes out drying precipitate, pulverize, obtain dry powder, get 100g dry powder, 4g sodium carboxymethyl cellulose, the sucrose of 50g, the sodium benzoate of 0.5g is dispersed in water, stirring and evenly mixing, and obtaining crude drug concentration is the solution of 4g/ml, boils and makes dissolving, and filter, subpackage after sterilizing, obtains syrup.
Embodiment 3
By Semen Sinapis Albae 28g, Radix Astragali 53g, Semen Armeniacae Amarum 35g, Ramulus Cinnamomi 46g, Flos Lonicerae 26g, Flos Inulae 19g, Herba Asari 25g, Fructus Jujubae 33g, Stigma Croci 28g, Pollen Typhae 23g, Cortex Phellodendri 40g, Semen Raphani 37g, Folium Mori 29g, Fructus Corni 41g, Semen Coicis 29g, Fructus Aurantii Immaturus 36g, Pericarpium Citri Reticulatae 30g, Rhizoma Zingiberis 33g and compound in rubus corchorifolius leaf 23g mixes, and decocts with water twice, adds for the 1st time relative to mixture quality 8 times of water gagings, decocts 2 hours, add for 2nd time relative to mixture quality 6 times of water gagings, decoct 1 hour, filter, merging filtrate, is concentrated into every 1ml about containing the clear paste of 1g medical material, adds hydrochloric acid and adjusts pH to be 1, limit edged stirs, and leaves standstill, with siphonage sucking-off supernatant, precipitate sucking filtration, to dry, wash with water to without obviously acid, takes out drying precipitate, pulverize, obtain dry powder, get 100g dry powder, 4g sodium carboxymethyl cellulose, the sucrose of 50g, the sodium benzoate of 0.5g is dispersed in water, stirring and evenly mixing, and obtaining crude drug concentration is the solution of 4g/ml, boils and makes dissolving, and filter, subpackage after sterilizing, obtains syrup.
Embodiment 4 granule
Semen Sinapis Albae 26g, Radix Astragali 46g, Semen Armeniacae Amarum 31g, Ramulus Cinnamomi 41g, Flos Lonicerae 22g, Flos Inulae 16g, Herba Asari 22g, Fructus Jujubae 30g, Stigma Croci 25g, Pollen Typhae 20g, Cortex Phellodendri 35g, Semen Raphani 35g, Folium Mori 26g, Fructus Corni 38g, Semen Coicis 25g, Fructus Aurantii Immaturus 33g, Pericarpium Citri Reticulatae 29g, Rhizoma Zingiberis 30g and compound in rubus corchorifolius leaf 20g mixes, decoct with water twice, add for 1st time relative to mixture quality 8 times of water gagings, decoct 2 hours, add for 2nd time relative to mixture quality 6 times of water gagings, decoct 1 hour, filter, merging filtrate, be concentrated into every 1ml about containing the clear paste of 1g medical material, adding hydrochloric acid adjusts pH to be 1, limit edged stirs, leave standstill, with siphonage sucking-off supernatant, precipitate sucking filtration is to dry, wash with water to nothing obviously acid, take out drying precipitate, pulverize, obtain dry powder, get dry powder 100g, add 25g cane sugar powder subsequently, be 75% ethanol soft material with determining alcohol, granulate with oscillating granulator, dry at 60 DEG C, granulate, obtain granule.
Embodiment 5 clinical data
Physical data
In April, 2010 ~ 2011 are selected to carry out 172 routine patients for the treatment of of chronic bronchitis in the author place hospital for object of study year April.Man 95 example, female 77 example, 13 ~ 75 years old age, average (45.0 ± 9.2) year, all patients all have certain cough, have sore throat before being admitted to hospital, sputum is sticky and in white, have wheezing sound, the symptom such as difficulty of breathing, health are weak, heating, the course of disease 2 months ~ 8 years.172 routine patients are divided into matched group and treatment group by its therapeutic modality difference.Treatment group 90 example, matched group 82 example.Two groups of patients are through statistical procedures in age, sex, the course of disease, risk factor, and no significant difference (P > 0.05), has comparability.
Therapeutic Method
The syrup that treatment group adopts the embodiment of the present invention 1 to prepare is treated, every day 3 times, each 1 bottle, every bottle of 10ml, while treatment, give adjustment on minimal invasive treatment and nursing and spiritual encouragement and comfort more, be careful in one's diet nutrition, and the food of polyphagia moistening the lung and resolving phlegm and high protein, homovitamin food, eliminate and avoid the suction of mist, dust and irritative gas, enhancing body resistance, improves clinical efficacy.
It is each that matched group gives Ceruroxime axetil capsules 0.25g, and every day 2 times is oral, and aminophylline tablets 100 ㎎ is each, and every day 3 times is oral.
All treat 2 courses for the treatment of for two groups.
Efficacy determination
Cure: the transference cures such as cough, expectoration, wheezing sound, breathe normal, X line sheet is normal; Effective: the symptoms such as cough, expectoration, wheezing sound have clear improvement, and breathing has slight difficulty once in a while, and X line sheet recovery situation reaches more than 85%; Effective: the symptoms such as cough, expectoration, wheezing sound make moderate progress, some difficulty of breathing, X line sheet recovery situation reaches more than 60%; Invalid: the symptoms such as cough, expectoration, wheezing sound are without improvement, and difficulty of breathing, X line sheet recovery situation is below 60%.
Inclusive criteria
(1) meet " diagnostic criteria that Chinese Medical Association's Pneumology Department meeting is determined "; (2) 10 ~ 80 years old age; (3) doctor can be accepted and carry out every detection; (4) without other primary diseases or psychosis medical history.
Statistical procedures
Adopt SPSS17.0 statistics software to analyze, contrast the cough of two groups of patients, expectoration, wheezing sound and X line sheet recovery situation, P < 0.05 has statistical significance for difference.
Therapeutic outcome
Before and after two groups of patient treatments, each condition of illness contrast, the results are shown in Table 1.
Before and after table 1 liang group patient treatment, each condition of illness compares (n)
After two courses for the treatment of, the comparitive study of two groups of patients, the results are shown in Table 2.
The comparitive study of table 2 liang group patient
Group n Cure Effective Effectively Invalid Total effective rate
Treatment group 90 52 26 10 2 97.8%
Matched group 82 32 27 13 10 87.8%
Can be found out by table 1 and table 2, adopt Chinese materia medica syrup of the present invention to have good curative effect in treatment chronic bronchitis.
All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (5)

1. one kind is used for the treatment of the Chinese medicine of chronic bronchitis, it is characterized in that, the crude drug of described Chinese medicine is only made up of Semen Sinapis Albae, the Radix Astragali, Semen Armeniacae Amarum, Ramulus Cinnamomi, Flos Lonicerae, Flos Inulae, Herba Asari, Fructus Jujubae, Stigma Croci, Pollen Typhae, Cortex Phellodendri, Semen Raphani, Folium Mori, Fructus Corni, Semen Coicis, Fructus Aurantii Immaturus, Pericarpium Citri Reticulatae, Rhizoma Zingiberis and compound in rubus corchorifolius leaf, in described Chinese medicine, the weight portion of each crude drug is respectively Semen Sinapis Albae 22 ~ 28 weight portion, the Radix Astragali 41 ~ 53 weight portion, Semen Armeniacae Amarum 27 ~ 35 weight portion, Ramulus Cinnamomi 37 ~ 46 weight portion, Flos Lonicerae 18 ~ 26 weight portion, Flos Inulae 12 ~ 19 weight portion, Herba Asari 19 ~ 25 weight portion, Fructus Jujubae 27 ~ 33 weight portion, Stigma Croci 21 ~ 28 weight portion, Pollen Typhae 18 ~ 23 weight portion, Cortex Phellodendri 30 ~ 40 weight portion, Semen Raphani 32 ~ 37 weight portion, Folium Mori 22 ~ 29 weight portion, Fructus Corni 35 ~ 41 weight portion, Semen Coicis 20 ~ 29 weight portion, Fructus Aurantii Immaturus 30 ~ 36 weight portion, Pericarpium Citri Reticulatae 26 ~ 30 weight portion, Rhizoma Zingiberis 27 ~ 33 weight portion and compound in rubus corchorifolius leaf 15 ~ 23 weight portion.
2. Chinese medicine as claimed in claim 1, it is characterized in that: in described Chinese medicine, the weight portion of each crude drug is respectively Semen Sinapis Albae 26 weight portion, the Radix Astragali 46 weight portion, Semen Armeniacae Amarum 31 weight portion, Ramulus Cinnamomi 41 weight portion, Flos Lonicerae 22 weight portion, Flos Inulae 16 weight portion, Herba Asari 22 weight portion, Fructus Jujubae 30 weight portion, Stigma Croci 25 weight portion, Pollen Typhae 20 weight portion, Cortex Phellodendri 35 weight portion, Semen Raphani 35 weight portion, Folium Mori 26 weight portion, Fructus Corni 38 weight portion, Semen Coicis 25 weight portion, Fructus Aurantii Immaturus 33 weight portion, Pericarpium Citri Reticulatae 29 weight portion, Rhizoma Zingiberis 30 weight portion and compound in rubus corchorifolius leaf 20 weight portion.
3 .chinese medicine as claimed in claim 1 or 2, is characterized in that: described Chinese drug preparation becomes syrup and granule.
4 .the preparation method of Chinese medicine described in claim 1 or 2, is characterized in that: when the dosage form of described Chinese medicine is granule, be specially,
Described crude drug component is mixed in proportion, decoct with water twice, add for 1st time relative to mixture quality 6 ~ 8 times of water gagings, decoct 2 hours, add for 2nd time relative to mixture quality 4 ~ 6 times of water gagings, decoct 1 hour, filter, merging filtrate, be concentrated into every 1ml about containing the clear paste of 1g medical material, adding hydrochloric acid adjusts pH to be 1, limit edged stirs, leave standstill, with siphonage sucking-off supernatant, precipitate sucking filtration is to dry, wash with water to nothing obviously acid, take out drying precipitate, pulverize, obtain dry powder, add relative to dry powder quality 20% ~ 30% cane sugar powder (mass percent) subsequently, be 75% ~ 85% ethanol soft material with determining alcohol, granulate with oscillating granulator, dry at 60 DEG C, granulate, obtain granule.
5 .the preparation method of Chinese medicine described in claim 1 or 2, is characterized in that: when the dosage form of described Chinese medicine is syrup, be specially,
Described crude drug component is mixed in proportion, decoct with water twice, add for 1st time relative to mixture quality 6 ~ 8 times of water gagings, decoct 2 hours, add for 2nd time relative to mixture quality 4 ~ 6 times of water gagings, decoct 1 hour, filter, merging filtrate, be concentrated into every 1ml about containing the clear paste of 1g medical material, adding hydrochloric acid adjusts pH to be 1, limit edged stirs, leave standstill, with siphonage sucking-off supernatant, precipitate sucking filtration is to dry, wash with water to nothing obviously acid, take out drying precipitate, pulverize, obtain dry powder, get 100 weight portion dry powder, 3 weight portion ~ 5 weight portion sodium carboxymethyl cellulose, the sucrose of 30 weight portion ~ 50 weight portions, the sodium benzoate of 0.5 weight portion ~ 1 weight portion is dispersed in water, stirring and evenly mixing, obtaining crude drug concentration is the solution of 3g/ml ~ 5g/ml, boil and make dissolving, filter, subpackage after sterilizing, obtain syrup.
CN201310326410.0A 2013-07-31 2013-07-31 Traditional Chinese medicine for treating chronic bronchitis Expired - Fee Related CN103341151B (en)

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CN1312103A (en) * 2001-02-23 2001-09-12 邓万发 Chinese medicine for treating dyspneic cough effectively
CN1733014A (en) * 2005-08-27 2006-02-15 孙恩义 Externally applied plaster for strengthening healthy energy to stop cough and relieve asthma
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CN102397454A (en) * 2011-11-20 2012-04-04 武汉卡倍欣科技发展有限公司 Pill for clearing away lung heat and relieving sore throat
CN102552773A (en) * 2012-02-06 2012-07-11 孟庆云 Drug for treating bronchitis and bronchial asthma of 7-15 year old children
CN102743730A (en) * 2012-07-11 2012-10-24 胡晓斌 Traditional Chinese medicine wine for treating arthritis and preparation method

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1312103A (en) * 2001-02-23 2001-09-12 邓万发 Chinese medicine for treating dyspneic cough effectively
CN1733014A (en) * 2005-08-27 2006-02-15 孙恩义 Externally applied plaster for strengthening healthy energy to stop cough and relieve asthma
CN101785839A (en) * 2010-04-23 2010-07-28 泰一和浦(北京)中医药研究院有限公司 Traditional Chinese medicine combination and preparation method thereof for hemoptysis treatment
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CN102552773A (en) * 2012-02-06 2012-07-11 孟庆云 Drug for treating bronchitis and bronchial asthma of 7-15 year old children
CN102743730A (en) * 2012-07-11 2012-10-24 胡晓斌 Traditional Chinese medicine wine for treating arthritis and preparation method

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