CN103520555B - Drug for treatment of migraine - Google Patents
Drug for treatment of migraine Download PDFInfo
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- CN103520555B CN103520555B CN201310514285.6A CN201310514285A CN103520555B CN 103520555 B CN103520555 B CN 103520555B CN 201310514285 A CN201310514285 A CN 201310514285A CN 103520555 B CN103520555 B CN 103520555B
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Abstract
Belonging to the field of traditional Chinese medicines, the invention discloses a drug for treatment of migraine. The drug provided by the invention comprises the following effective raw material components: Clerodendrum japonicum leaves, Parthenocissus tricuspidata, wild opium poppies, pomelo leaves, litmus, roots of Dentiferous Dendropanax, Cynanchum amplexicaule, Orixa japonica, crape myrtle roots, Astilbe chinensis, Piper longum, Hydrocotyle vulgaris, ergot, fructus viticis, radix clematidis and Korean Mondshood Roots. The drug provided by the invention has the efficacy of nourishing liver and dispelling wind, activating blood circulation and inducing resuscitation. Compared with other similar drugs, the drug provided by the invention has the characteristics of precise compatibility, mild drug properties and obvious curative effect, can rapidly ease migraine symptoms, dredge qi, blood and venations of lesions, promote vasodilatation, regulate the body mechanism, excite the inner analgesic system, relieve vasospasm, inhibit platelet aggregation and blood vessel substance release, thus curing diseases. The drug for treatment of migraine has the characteristics of good curative effect, quick effect, no toxic or side effect, convenient taking, easy absorption, low cost, treatment of both symptoms and root causes, and hard recurrence after cure.
Description
Affiliated technical field
The present invention relates to the field of Chinese medicines, relate in particular to one and treat migrainous medicine.
Background technology
Migraine is the most common clinically vascular headache, presents the throbbing pain consistent with pulsation or distending pain, and the cough of bowing, be heated, exert oneself etc. all can make headache increase the weight of, and is acute relapse outbreak; Migraine is a kind of common repeated relapsing with symptoms such as nauseating, vomiting, photophobia, phonophobias headache, patient's main clinical manifestation is head one side or bilateral distending pain, be and beat or rest pain, periodical attack, unilateral headache when outbreak, and sharp ache sometimes, tool pulsation, this headache is usually from eye socket or frons, to half sidepiece expansion, also can spread all over whole head, its sickness rate is up to 8.4%～28%.Migrainous outbreak is repeatedly had a strong impact on patient's quality of life, study and work ability, its age of onset is many at 20～40 years old, it is rich creative age bracket, so, in the world wide that at present World Health Organization (WHO) lists, cause migraine in all diseases of disability to be listed as the 19th.Primary disease cause of disease complexity, modern study proposed neurogenic inflammation theory, around and the sensitization of nervus centralis sensation, neuron exaltation and voltage rely on channel abnormal, cortical spreading depression, neurotransmitter theory etc., each theory has evidence relatively reliably; Correspondingly, the medicine kind of primary disease also has a lot, but the medication effect of producing according to these theories is very limited, and the abuse of Western medicine becomes one of reason of intractable headache.
A lot of Drug therapy migraine can make pain relief, but drug withdrawal can show effect again later repeatedly, and migrainous treatment often has persistency and repeatability, in the urgent need to a kind ofly treating that the migraine time limit is short, curative effect is high, the low medicine of rate repeatedly.
Summary of the invention
The invention provides one and treat migrainous medicine, medicine of the present invention has the nourishing the liver sensible effect of dispeling the wind, invigorate blood circulation, and compares with other similar drugs, it is rigorous that medicine of the present invention has compatibility, the property of medicine is gentle, and feature evident in efficacy can be alleviated rapidly cephalagra, dredging focus QI and blood venation, promote vasodilation, mechanism in control agent, excited inherent analgesia system, remove vasospasm, anticoagulant and angiogenic substance and discharge, disease is rehabilitated.
For achieving the above object, technical scheme of the present invention is implemented as follows:
One is treated migrainous medicine, and raw material composition and the parts by weight of making described effective ingredient are:
46～71 parts of 50～76 parts of Folium Citri grandis of 51～76 parts of Fructus Papaveris nudicaulis of 56～81 portions of Radix seu Caulis Parthenocissi tricuspidataes of Folium Clerodendri japonici
36～57 parts of 36～61 parts of Caulis Seu Folium Callicarpae Kwangtungensis of 41～66 parts of Radix Cynanchi Amplexicauliss of 42～69 parts of Radix Dendropanacis of Herba Cladoniae rangiferinae
31～44 parts of 31～51 parts of Herba Androsaces umbellataes of 33～52 parts of Fructus Piperis Longi of 36～56 parts of Rhizoma Astilbes Myrianthaes of Radix Lagerstroemia indica L.
10～30 parts of 16～36 parts of Radix Aconiti Coreanis of 23～39 parts of Radix Clematidis of 26～41 parts of Fructus Viticises of Ergota.
Raw material composition and the parts by weight of making described effective ingredient are:
51～63 parts of 52～71 parts of Folium Citri grandis of 56～72 parts of Fructus Papaveris nudicaulis of 61～76 portions of Radix seu Caulis Parthenocissi tricuspidataes of Folium Clerodendri japonici
40～54 parts of 41～59 parts of Caulis Seu Folium Callicarpae Kwangtungensis of 46～61 parts of Radix Cynanchi Amplexicauliss of 46～66 parts of Radix Dendropanacis of Herba Cladoniae rangiferinae
32～41 parts of 34～46 parts of Herba Androsaces umbellataes of 36～49 parts of Fructus Piperis Longi of 39～51 parts of Rhizoma Astilbes Myrianthaes of Radix Lagerstroemia indica L.
12～20 parts of 19～26 parts of Radix Aconiti Coreanis of 26～36 parts of Radix Clematidis of 29～38 parts of Fructus Viticises of Ergota.
Raw material composition and the parts by weight of making described effective ingredient are:
54～60 parts of 56～66 parts of Folium Citri grandis of 61～67 parts of Fructus Papaveris nudicaulis of 66～71 portions of Radix seu Caulis Parthenocissi tricuspidataes of Folium Clerodendri japonici
44～51 parts of 46～56 parts of Caulis Seu Folium Callicarpae Kwangtungensis of 48～56 parts of Radix Cynanchi Amplexicauliss of 51～61 parts of Radix Dendropanacis of Herba Cladoniae rangiferinae
35～38 parts of 36～41 parts of Herba Androsaces umbellataes of 39～45 parts of Fructus Piperis Longi of 41～46 parts of Rhizoma Astilbes Myrianthaes of Radix Lagerstroemia indica L.
14～16 parts of 21～23 parts of Radix Aconiti Coreanis of 29～31 parts of Radix Clematidis of 31～36 parts of Fructus Viticises of Ergota.
Raw material composition and the parts by weight of making described effective ingredient are:
57 parts of 61 parts of Folium Citri grandis of 64 parts of Fructus Papaveris nudicaulis of 69 portions of Radix seu Caulis Parthenocissi tricuspidataes of Folium Clerodendri japonici
47 parts of 51 parts of Caulis Seu Folium Callicarpae Kwangtungensis of 52 parts of Radix Cynanchi Amplexicauliss of 56 parts of Radix Dendropanacis of Herba Cladoniae rangiferinae
36 parts of 39 parts of Herba Androsaces umbellataes of 42 parts of Fructus Piperis Longi of 44 parts of Rhizoma Astilbes Myrianthaes of Radix Lagerstroemia indica L.
15 parts of 22 parts of Radix Aconiti Coreanis of 30 parts of Radix Clematidis of 34 parts of Fructus Viticises of Ergota.
Treat a preparation method for migrainous medicine, comprise following processing step:
(1) Fructus Papaveris nudicaulis, Folium Citri grandis, Herba Cladoniae rangiferinae, Radix Cynanchi Amplexicaulis, Caulis Seu Folium Callicarpae Kwangtungensis, Radix Lagerstroemia indica L., Rhizoma Astilbes Myrianthae, Fructus Piperis Longi, Ergota and Fructus Viticis are cleaned, put into container, add the distilled water of 8～10 times of amounts, soak after 5～6 hours, boil 3～4 hours, extract; Again add 6～8 times of amount distilled water, boil 2～3 hours, extract; Finally, add 4～6 times of amount distilled water, heated and boiled 1～2 hour, extracts; Merge three times extracting solution, filter, obtain filtrate, be condensed into the thick paste that at 60 ℃, relative density is 1.10～1.16, for subsequent use;
(2) Folium Clerodendri japonici, Herba Androsaces umbellatae and Radix Aconiti Coreani are mixed, after mix homogeneously, carry out pulverization process, grind into powder, cross 120 order fine powders, for subsequent use;
(3) Radix seu Caulis Parthenocissi tricuspidatae and Radix Dendropanacis are cleaned, immersed 70% the alcohol solution dipping 2～3 hours of 6 times of amounts, heating extraction 5 hours, reclaims ethanol, filter, and the thick paste that under 60 ℃ of environment of simmer down to, relative density is 1.10～1.14, for subsequent use;
(4) Radix Clematidis is mixed thoroughly vexed with yellow wine, put in pot by a slow fire micro-fried dry, taking-up cools, then adds 2～3 times of amount distilled water, and heated and boiled 1～2 hour is extracted, and filters, and obtains filtrate, for subsequent use;
(5) above-mentioned steps (1)～(4) prepared thick paste, fine powder and filtrate are mixed, add adjuvant, utilize modern advanced pharmacy science and technology, make tablet, obtain the migrainous medicine for the treatment of of the present invention.
The property of medicine of the present invention's medicine used is as follows:
Folium Clerodendri japonici: pungent, sweet, flat; Return liver, spleen channel.Dispel the wind, dissipating blood stasis, removing toxic substances and promoting subsidence of swelling.Main migraine, traumatic injury congestive edema, carbuncle sore tumefacting virus." Fujian traditional herbal medicine " carries: " promoting pus discharge and removing toxic substances, granulation promoting is held back mouth.”
Radix seu Caulis Parthenocissi tricuspidatae: acrid in the mouth is micro-puckery, warm in nature; Return Liver Channel.Invigorate blood circulation, dispel the wind, pain relieving.Blood stasis after managing property, has piece in abdomen, leucorrhea with red and white discharge, rheumatism bones and muscles pain, migraine." Jiangxi Chinese medicine " carries: " promoting blood circulation by removing wind.All bones and muscles pain, and married woman's red and white leukorrhea inferior due to stasis person, all cure mainly it.When near, as wind-expelling pain-stopping medicine, be applicable to joint rheumatism, waist foot weakness waits disease.”
Fructus Papaveris nudicaulis: acid, micro-hardship, puckery, cool, poisonous; Return lung, kidney, stomach, large intestine channel.The cough-relieving of sword lung, relieving diarrhea with astringents, analgesia.Main chronic cough is panted, and dysentery is had blood in stool, proctoptosis, seminal emission, leukorrhagia, headache, stomachache, dysmenorrhea." Chinese herbal medicine handbook is commonly used in northeast " carries: " analgesia, cough-relieving, Dingchuan, antidiarrheal.Control nervous headache, migraine, chronic cough, pants, and dysentery is had blood in stool, seminal emission, menstrual pain, leucorrhea, proctoptosis, acute or chronic gastritis, gastric ulcer, stomachache.”
Folium Citri grandis: pungent, temperature.Control wind syndrome of head pain, arthralgia due to cold-dampnes, dyspepsia stomachache." detailed outline " carries: " control wind syndrome of head pain, smash subsides temple with Bulbus Allii Fistulosi.”
Herba Cladoniae rangiferinae: salty, cold.Removing damp-heat, analgesia, cooling blood for hemostasis.Cure mainly knife injury, rheumatalgia, hemoptysis, headache, migraine." Shaanxi Chinese herbal medicine " carries: " dispel the wind, analgesia.Control headache, migraine.”
Radix Dendropanacis: sweet, temperature.Expelling wind and removing dampness, relaxing muscles and tendons to promote blood circulation.For migraine, brachial plexus neuritis, rheumatic arthritis, rheumatoid arthritis, lumbar muscle strain, chronic lambago and skelalgia, hemiplegia, traumatic injury, bruise; External is controlled on cutter hemorrhage." Zhejiang conventional medical herbs among the people " carries: " expelling wind and removing dampness, relaxing muscles and tendons to promote blood circulation, pain relieving.”
Radix Cynanchi Amplexicaulis: bitter in the mouth, pungent, property is flat; Return lung, spleen channel.Heat-clearing and toxic substances removing, wind-damp dispelling, promoting blood circulation and detumescence.Main air pain of dampness syndrome, migraine, lumbago, menoxenia, acute mastitis, carbuncle furunculosis." Jiangxi medical herbs " carries: " promoting flow of QI and blood, subduing swelling and detoxicating.Control acute mastitis, painful and swollen testis, eczema, migraine, acute hepatitis, acute gastroenteritis, menoxenia, waist abdominal distention and pain, venom.”
Caulis Seu Folium Callicarpae Kwangtungensis: sour and astringent, nontoxic.Pain relieving, hemostasis.Control haematemesis chest pain, migraine, stomachache, traumatic hemorrhage.
Radix Lagerstroemia indica L.: mildly bitter flavor, cold nature.Clearing away heat-damp and promoting diuresis, promoting blood circulation and hemostasis, pain relieving.Main dysentery, edema, burn and scald, eczema, carbuncle sore tumefacting virus, traumatic injury, metrorrhagia, migraine, toothache, dysmenorrhea, puerperal abdonimal pain.
Rhizoma Astilbes Myrianthae: acrid in the mouth, micro-puckery, property is flat; Return lung, Liver Channel.Dispel the wind and deliver, analgesia.Control Common Cold, headache, migraine.
Fructus Piperis Longi: pungent, heat; Return stomach, large intestine channel.Warming spleen and stomach for dispelling cold, therapeutic method to keep the adverse QI flowing downwards pain relieving.For coldness and pain in the epigastrium, vomiting, has loose bowels, migraine, external treatment toothache." detailed outline " carries: " Fructus Piperis Longi, is headache, nasal sinusitis, toothache key medicine, gets it and hotly can enter the loose superficial heat of Yangming Channel also.”
Herba Androsaces umbellatae: hardship, pungent, cold nature; Return lung, liver, spleen channel.Heat-clearing and toxic substances removing, reducing swelling and alleviating pain.Cure mainly laryngopharynx swelling and pain, aphtha, toothache, headache, acute conjunctivitis, rheumatic arthralgia, asthma, stranguria with turbid discharge, treats pyogenic infections from tumour or sore, burn and scald, venom, traumatic injury.
Ergota: hardship, pungent, flat, poisonous; Return liver, kidney channel.Oxytocin bleeding, pain relieving.Main metrorrhagia, migraine." plateau Chinese herbal treatment handbook " carries: " control migraine.”
Fructus Viticis: pungent, bitter, be slightly cold; Return bladder, liver, stomach warp.Dispelling wind and heat pathogens, the clear sharp head.For anemopyretic cold headache, gingivitis, the many tear of conjunctival congestion, poor vision, has a dizzy spell." pearl sac " carries: " cool all menses, only headache, pain in argument eyeball.”
Radix Clematidis: pungent, salty, temperature; Return urinary bladder channel.Expelling wind and removing dampness, removing obstruction in the collateral to relieve pain.For rheumatic arthralgia, numb limbs and tense tendons, the contracture of muscle arteries and veins, joint stuffiness, the bone larynx of choking with sobs." Guangxi Chinese herbal medicine " carries: " expelling wind and removing dampness, dredge the meridian passage, diuresis, pain relieving.Dispelling the wind and dampness pathogens osteodynia, jaundice, edema, dysuria, migraine, internal traumatic injury.”
Radix Aconiti Coreani: pungent, sweet, heat, poisonous; Return liver, stomach warp.The expectorant that dispels the wind, arresting convulsion epilepsy, dispersing cold for relieving pain.In master, wind-phlegm is stopped up, facial hemiparalysis, epilepsy, migraine and general headache, dizziness due to wind-phlegm, tetanus, infantile convulsion, rheumatic arthralgia, skin infection scabies, skin pruritus." Chinese materia medica " carries: " control migraine and general headache, tetanus.”
The present invention compared with prior art, has following beneficial effect:
1, medicine of the present invention has the nourishing the liver sensible effect of dispeling the wind, invigorate blood circulation, compare with other similar drugs, it is rigorous that medicine of the present invention has compatibility, and the property of medicine is gentle, feature evident in efficacy, can alleviate rapidly cephalagra, dredging focus QI and blood venation, promotes vasodilation, mechanism in control agent, excited inherent analgesia system, removes vasospasm, anticoagulant and angiogenic substance and discharges, and disease is rehabilitated.
2, medicine of the present invention has good effect to treatment migraine, and instant effect, has no side effect, and taking convenience is easy to absorb, with low cost, treating both the principal and secondary aspects of a disease, the distinguishing feature of difficult recurrence after curing.
The specific embodiment
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
Raw material composition and the weight of effective ingredient of the present invention are:
Folium Clerodendri japonici 76g Radix seu Caulis Parthenocissi tricuspidatae 72g Fructus Papaveris nudicaulis 71g Folium Citri grandis 63g
Herba Cladoniae rangiferinae 66g Radix Dendropanacis 61g Radix Cynanchi Amplexicaulis 59g Caulis Seu Folium Callicarpae Kwangtungensis 54g
Radix Lagerstroemia indica L. 51g Rhizoma Astilbes Myrianthae 49g Fructus Piperis Longi 46g Herba Androsaces umbellatae 41g
Ergota 38g Fructus Viticis 36g Radix Clematidis 26g Radix Aconiti Coreani 20g.
Treat a preparation method for migrainous medicine, comprise following processing step:
(1) Fructus Papaveris nudicaulis, Folium Citri grandis, Herba Cladoniae rangiferinae, Radix Cynanchi Amplexicaulis, Caulis Seu Folium Callicarpae Kwangtungensis, Radix Lagerstroemia indica L., Rhizoma Astilbes Myrianthae, Fructus Piperis Longi, Ergota and Fructus Viticis are cleaned, put into container, add the distilled water of 8～10 times of amounts, soak after 5～6 hours, boil 3～4 hours, extract; Again add 6～8 times of amount distilled water, boil 2～3 hours, extract; Finally, add 4～6 times of amount distilled water, heated and boiled 1～2 hour, extracts; Merge three times extracting solution, filter, obtain filtrate, be condensed into the thick paste that at 60 ℃, relative density is 1.10～1.16, for subsequent use;
(2) Folium Clerodendri japonici, Herba Androsaces umbellatae and Radix Aconiti Coreani are mixed, after mix homogeneously, carry out pulverization process, grind into powder, cross 120 order fine powders, for subsequent use;
(3) Radix seu Caulis Parthenocissi tricuspidatae and Radix Dendropanacis are cleaned, immersed 70% the alcohol solution dipping 2～3 hours of 6 times of amounts, heating extraction 5 hours, reclaims ethanol, filter, and the thick paste that under 60 ℃ of environment of simmer down to, relative density is 1.10～1.14, for subsequent use;
(4) Radix Clematidis is mixed thoroughly vexed with yellow wine, put in pot by a slow fire micro-fried dry, taking-up cools, then adds 2～3 times of amount distilled water, and heated and boiled 1～2 hour is extracted, and filters, and obtains filtrate, for subsequent use;
(5) above-mentioned steps (1)～(4) prepared thick paste, fine powder and filtrate are mixed, add adjuvant, utilize modern advanced pharmacy science and technology, make tablet, obtain the migrainous medicine for the treatment of of the present invention.
Usage and dosage: oral, every day 3 times, each 2, warm water delivery service after meal; Within 7 days, be 1 course for the treatment of, 2 courses for the treatment of of the lighter, severe one can be fully recovered 4～5 courses for the treatment of.
Embodiment 2
Raw material composition and the weight of effective ingredient of the present invention are:
Folium Clerodendri japonici 71g Radix seu Caulis Parthenocissi tricuspidatae 67g Fructus Papaveris nudicaulis 66g Folium Citri grandis 60g
Herba Cladoniae rangiferinae 61g Radix Dendropanacis 56g Radix Cynanchi Amplexicaulis 56g Caulis Seu Folium Callicarpae Kwangtungensis 51g
Radix Lagerstroemia indica L. 46g Rhizoma Astilbes Myrianthae 45g Fructus Piperis Longi 41g Herba Androsaces umbellatae 38g
Ergota 36g Fructus Viticis 31g Radix Clematidis 23g Radix Aconiti Coreani 16g.
Process for preparing medicine processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Embodiment 3
Raw material composition and the weight of effective ingredient of the present invention are:
Folium Clerodendri japonici 69g Radix seu Caulis Parthenocissi tricuspidatae 64g Fructus Papaveris nudicaulis 61g Folium Citri grandis 57g
Herba Cladoniae rangiferinae 56g Radix Dendropanacis 52g Radix Cynanchi Amplexicaulis 51g Caulis Seu Folium Callicarpae Kwangtungensis 47g
Radix Lagerstroemia indica L. 44g Rhizoma Astilbes Myrianthae 42g Fructus Piperis Longi 39g Herba Androsaces umbellatae 36g
Ergota 34g Fructus Viticis 30g Radix Clematidis 22g Radix Aconiti Coreani 15g.
Process for preparing medicine processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Embodiment 4
Raw material composition and the weight of effective ingredient of the present invention are:
Folium Clerodendri japonici 66g Radix seu Caulis Parthenocissi tricuspidatae 61g Fructus Papaveris nudicaulis 56g Folium Citri grandis 54g
Herba Cladoniae rangiferinae 51g Radix Dendropanacis 48g Radix Cynanchi Amplexicaulis 46g Caulis Seu Folium Callicarpae Kwangtungensis 44g
Radix Lagerstroemia indica L. 41g Rhizoma Astilbes Myrianthae 39g Fructus Piperis Longi 36g Herba Androsaces umbellatae 35g
Ergota 31g Fructus Viticis 29g Radix Clematidis 21g Radix Aconiti Coreani 14g.
Process for preparing medicine processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Embodiment 5
Raw material composition and the weight of effective ingredient of the present invention are:
Folium Clerodendri japonici 61g Radix seu Caulis Parthenocissi tricuspidatae 56g Fructus Papaveris nudicaulis 52g Folium Citri grandis 51g
Herba Cladoniae rangiferinae 46g Radix Dendropanacis 46g Radix Cynanchi Amplexicaulis 41g Caulis Seu Folium Callicarpae Kwangtungensis 40g
Radix Lagerstroemia indica L. 39g Rhizoma Astilbes Myrianthae 36g Fructus Piperis Longi 34g Herba Androsaces umbellatae 32g
Ergota 29g Fructus Viticis 26g Radix Clematidis 19g Radix Aconiti Coreani 12g.
Process for preparing medicine processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Clinical data:
1, case selection:
As the migrainous medicine for the treatment of, the routine clinical observation of migraineur 200 that selection is made a definite diagnosis, patient is divided into two groups for the treatment of group and matched groups, treatment group 100 examples, wherein male's 47 examples at random, women's 53 examples, 21～63 years old age, 45.4 years old mean age, the shortest person of the course of disease 3 months, elder 15 years, average 8.2 years.Matched group 100 examples, wherein male's 48 examples, women's 52 examples, 20～62 years old age, 44.9 years old mean age, the shortest person of the course of disease 4 months, elder 14 years, average 7.9 years.
The course of disease, the degrees of symptoms for the treatment of group and two groups of cases of matched group are basically identical, without significant difference, have comparability.
2, medicament selection:
Treatment group is taken medicine of the present invention, oral, every day 3 times, each 2, warm water delivery service after meal; Within 7 days, be 1 course for the treatment of, 2 courses for the treatment of of the lighter, severe one can be fully recovered 4～5 courses for the treatment of.
Matched group is taken ibuprofen modified release capsule, oral, and each 1, every day 2 times, sooner or later respectively once.
3, efficacy determination:
(1) cure: headache and simultaneous phenomenon disappear, and rheoencephalogram is normal.
(2) effective: headache and simultaneous phenomenon disappear substantially, rheoencephalogram normal.
(3) effective: headache attack degree and simultaneous phenomenon alleviate, and rheoencephalogram is improved.
(4) invalid: headache and simultaneous phenomenon are without improvement.
4, result:
Select in the treatment group of medicine of the present invention, cure 47 examples, effective 26 examples, effective 25 examples, invalid 2 examples, cure rate 47%, total effective rate 98%.
In matched group, cure 20 examples, effective 16 examples, effective 13 examples, invalid 51 examples, cure rate 20%, total effective rate 49%.
Above result demonstration, the cure rate for the treatment of group and total effective rate are apparently higher than matched group.
Model case is given an example:
1, Guo, man, 24 years old, Yuncheng, Shanxi people, had a headache 2 years, and two temple pain is felt sick sometimes, and sustainable 1 day of pain connects and eye socket, red tongue, body is bigger, and tongue is white, stringy pulse; Take medicine of the present invention, every day 3 times, each 2, warm water delivery service after meal, take after 1 course for the treatment of, when rise morning, still have a headache, tongue body is bigger, and tongue is white, stringy pulse, continued to take after 1 course for the treatment of, did not send out headache; yellow urine, and tongue body is bigger, and matter is red; tongue is white, and stringy pulse continues to take after 1 course for the treatment of; migraine heals entirely, followed up a case by regular visits to, so far not recurrence.
2, Wu, female, 35 years old, people from Dandong, paroxysmal right side migraine 2 months, often vexed, dreaminess, lustreless complexion, white and greasy fur is thicker, and matter is light, and thready pulse chi is soft, and blood pressure 145/105mmHg used multiple Drug therapy, and poor effect cannot be cured.To our hospital afterwards, take medicine of the present invention, to take after 1 course for the treatment of, symptom disappears substantially, takes after the 2nd course for the treatment of, and migraine heals entirely, follows up a case by regular visits to, so far not recurrence.
3, Fang, female, 42 years old, people from Baicheng, Jilin, had a headache 5 years, and left side temple are main, jumping pain, sleep difference can be brought out, monthly aches 2～3 times, persistence, fever sensation of the face, dark tongue quality, body is large, and tongue is white, stringy pulse.Take after 1 course for the treatment of, headache is not sent out, time have a fever sensation of the face, sleep also take a favorable turn, dark tongue quality, tongue is white, stringy pulse.Continue to take after 1 course for the treatment of, only show effect 11 middle of the month of having a headache, lighter, dark tongue quality, and body is bigger, and tongue is white, stringy pulse.Continue to take after 1 course for the treatment of, headache disappears, time have fever sensation of the face, tongue body is large, matter is red dark, tongue is white, stringy and rolling pulse.Effect of follow-up visit by telephone after 3 months, headache is again without outbreak.
4, high certain, man, 56 years old, Yancheng, Jiangsu Province people, had a headache 5 years, is twinge, sweating, bitter taste, flushing, thirsty, dark tongue quality, tongue is white, and body is bigger, and deep and stringy pulse was taken after the 2nd course for the treatment of, and headache alleviates, perspire few, ponder over red tongue, tongue white spirit, deep and stringy pulse, continue to take after the 3rd course for the treatment of, headache, perspiration all alleviate, dark tongue quality, and point is red, and tongue is white, deep and stringy pulse, continued to take after the 4th course for the treatment of, and headache disappears, and followed up a case by regular visits to, so far not recurrence.
5, Cai, female, 61 years old, Zhejiang Hangzhou people, had a headache 7 years, increases the weight of 2 days, two temple and occiput pain, with dizziness, without nausea and vomiting, tongue body is large, and matter is red, tongue is white, and stringy pulse was taken after the 2nd course for the treatment of, and headache, dizziness alleviate, hyperhidrosis, tongue body is large, and matter is dark, and tongue is white, and deep and stringy pulse continued to take after the 4th course for the treatment of, headache is basic to disappear, and dizziness obviously alleviates, and tongue body is large, and matter is red dark, and tongue is greasy in vain, deep and stringy pulse, continued to take after the 5th course for the treatment of, and transference cure, follows up a case by regular visits to, so far not recurrence.
Claims (5)
1. the migrainous medicine for the treatment of, is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:
46～71 parts of 50～76 parts of Folium Citri grandis of 51～76 parts of Fructus Papaveris nudicaulis of 56～81 portions of Radix seu Caulis Parthenocissi tricuspidataes of Folium Clerodendri japonici
36～57 parts of 36～61 parts of Caulis Seu Folium Callicarpae Kwangtungensis of 41～66 parts of Radix Cynanchi Amplexicauliss of 42～69 parts of Radix Dendropanacis of Herba Cladoniae rangiferinae
31～44 parts of 31～51 parts of Herba Androsaces umbellataes of 33～52 parts of Fructus Piperis Longi of 36～56 parts of Rhizoma Astilbes Myrianthaes of Radix Lagerstroemia indica L.
10～30 parts of 16～36 parts of Radix Aconiti Coreanis of 23～39 parts of Radix Clematidis of 26～41 parts of Fructus Viticises of Ergota.
2. one according to claim 1 is treated migrainous medicine, it is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:
51～63 parts of 52～71 parts of Folium Citri grandis of 56～72 parts of Fructus Papaveris nudicaulis of 61～76 portions of Radix seu Caulis Parthenocissi tricuspidataes of Folium Clerodendri japonici
40～54 parts of 41～59 parts of Caulis Seu Folium Callicarpae Kwangtungensis of 46～61 parts of Radix Cynanchi Amplexicauliss of 46～66 parts of Radix Dendropanacis of Herba Cladoniae rangiferinae
32～41 parts of 34～46 parts of Herba Androsaces umbellataes of 36～49 parts of Fructus Piperis Longi of 39～51 parts of Rhizoma Astilbes Myrianthaes of Radix Lagerstroemia indica L.
12～20 parts of 19～26 parts of Radix Aconiti Coreanis of 26～36 parts of Radix Clematidis of 29～38 parts of Fructus Viticises of Ergota.
3. one according to claim 1 is treated migrainous medicine, it is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:
54～60 parts of 56～66 parts of Folium Citri grandis of 61～67 parts of Fructus Papaveris nudicaulis of 66～71 portions of Radix seu Caulis Parthenocissi tricuspidataes of Folium Clerodendri japonici
44～51 parts of 46～56 parts of Caulis Seu Folium Callicarpae Kwangtungensis of 48～56 parts of Radix Cynanchi Amplexicauliss of 51～61 parts of Radix Dendropanacis of Herba Cladoniae rangiferinae
35～38 parts of 36～41 parts of Herba Androsaces umbellataes of 39～45 parts of Fructus Piperis Longi of 41～46 parts of Rhizoma Astilbes Myrianthaes of Radix Lagerstroemia indica L.
14～16 parts of 21～23 parts of Radix Aconiti Coreanis of 29～31 parts of Radix Clematidis of 31～36 parts of Fructus Viticises of Ergota.
4. one according to claim 1 is treated migrainous medicine, it is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:
57 parts of 61 parts of Folium Citri grandis of 64 parts of Fructus Papaveris nudicaulis of 69 portions of Radix seu Caulis Parthenocissi tricuspidataes of Folium Clerodendri japonici
47 parts of 51 parts of Caulis Seu Folium Callicarpae Kwangtungensis of 52 parts of Radix Cynanchi Amplexicauliss of 56 parts of Radix Dendropanacis of Herba Cladoniae rangiferinae
36 parts of 39 parts of Herba Androsaces umbellataes of 42 parts of Fructus Piperis Longi of 44 parts of Rhizoma Astilbes Myrianthaes of Radix Lagerstroemia indica L.
15 parts of 22 parts of Radix Aconiti Coreanis of 30 parts of Radix Clematidis of 34 parts of Fructus Viticises of Ergota.
5. a preparation method for the treatment of migrainous medicine as described in claim 1～4 any one, is characterized in that: comprise following processing step:
(1) Fructus Papaveris nudicaulis, Folium Citri grandis, Herba Cladoniae rangiferinae, Radix Cynanchi Amplexicaulis, Caulis Seu Folium Callicarpae Kwangtungensis, Radix Lagerstroemia indica L., Rhizoma Astilbes Myrianthae, Fructus Piperis Longi, Ergota and Fructus Viticis are cleaned, put into container, add the distilled water of 8～10 times of amounts, soak after 5～6 hours, boil 3～4 hours, extract; Again add 6～8 times of amount distilled water, boil 2～3 hours, extract; Finally, add 4～6 times of amount distilled water, heated and boiled 1～2 hour, extracts; Merge three times extracting solution, filter, obtain filtrate, be condensed into the thick paste that at 60 ℃, relative density is 1.10～1.16, for subsequent use;
(2) Folium Clerodendri japonici, Herba Androsaces umbellatae and Radix Aconiti Coreani are mixed, after mix homogeneously, carry out pulverization process, grind into powder, cross 120 order fine powders, for subsequent use;
(3) Radix seu Caulis Parthenocissi tricuspidatae and Radix Dendropanacis are cleaned, immersed 70% the alcohol solution dipping 2～3 hours of 6 times of amounts, heating extraction 5 hours, reclaims ethanol, filter, and the thick paste that under 60 ℃ of environment of simmer down to, relative density is 1.10～1.14, for subsequent use;
(4) Radix Clematidis is mixed thoroughly vexed with yellow wine, put in pot by a slow fire micro-fried dry, taking-up cools, then adds 2～3 times of amount distilled water, and heated and boiled 1～2 hour is extracted, and filters, and obtains filtrate, for subsequent use;
(5) above-mentioned steps (1)～(4) prepared thick paste, fine powder and filtrate are mixed, add adjuvant, make tablet, obtain the described migrainous medicine for the treatment of.
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| CN103893488A (en) * | 2014-04-19 | 2014-07-02 | 薛俊芳 | Chinese medicine preparation for treating migraine and preparation method thereof |
| CN104189337A (en) * | 2014-08-31 | 2014-12-10 | 刘黎霞 | Traditional Chinese medicine for treating migraine |
| CN104274668A (en) * | 2014-10-15 | 2015-01-14 | 邹秀兰 | Medicine for treating migraine |
| CN104622920A (en) * | 2015-01-22 | 2015-05-20 | 李健 | Pharmaceutical composition for promoting healing of skin wound and preparation method thereof |
| CN104857313A (en) * | 2015-06-24 | 2015-08-26 | 吉首大学 | Traditional Chinese medicine composition preparation for treating migraine and preparation method thereof |
| CN106389859A (en) * | 2016-11-07 | 2017-02-15 | 成都泠汐尚品科技有限公司 | Traditional Chinese medicine composition for treating cluster headache |
| CN106344706A (en) * | 2016-11-07 | 2017-01-25 | 成都泠汐尚品科技有限公司 | Traditional Chinese medicine compound for treating headache caused by neurodynia |
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| CN102068624A (en) * | 2009-11-23 | 2011-05-25 | 史海霞 | Traditional Chinese medicine for treatment of hemicrania |
| CN102225105B (en) * | 2011-06-21 | 2013-02-06 | 刘运文 | Medicine for treating migraine |
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