CN103721006A - Traditional Chinese medicinal anesthetic and preparation method thereof - Google Patents
Traditional Chinese medicinal anesthetic and preparation method thereof Download PDFInfo
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- CN103721006A CN103721006A CN201410016034.XA CN201410016034A CN103721006A CN 103721006 A CN103721006 A CN 103721006A CN 201410016034 A CN201410016034 A CN 201410016034A CN 103721006 A CN103721006 A CN 103721006A
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Abstract
The invention discloses a traditional Chinese medicinal anesthetic and a preparation method thereof, and belongs to the field of traditional Chinese medicinal anesthetics. The effective component of the traditional Chinese medicinal anesthetic is prepared from ovateleaf holly bark, ligusticum wallichii, paederia scandens, cape jasmine, calcined oyster, tribulusterrestris, mint, herba houttuyniae, cortex albiziae, perilla root, chinaroot greenbrier leaf, jasmine, angelica pubescens, aconitum kusnezoffii, pnudicaule and loess. The traditional Chinese medicinal anesthetic has the effects of anesthesia and analgesia, relieving spasm and paralyzing muscles, has a remarkable anesthesia effect in clinical operation treatment, has a remarkable analgesia effect to pains caused by nerves, is convenient to use, safe and reliable, does not have toxic or side effect, and can be widely applied to anesthetic operation in clinical operation medical treatment.
Description
Affiliated technical field
The present invention relates to Chinese drug anesthesia field, relate in particular to a kind of herbal anesthetic and preparation method.
Background technology
Anesthesia be while performing a surgical operation or be eliminate pain while carrying out diagnostic test operation, ensure patient safety, create the whole bag of tricks that good surgical condition is taked, mainly comprise general anesthesia, local anesthesia and combined anesthesia.Wherein general anesthesia refers to from respiratory tract and sucks or intravenous injection anaesthetic, occurs the state of reversibility loss of consciousness, analgesis.
At present, have multiple anesthesia product in China market, be used for greatly medically, and price is higher, being rarely used in life and using.Propofol is a kind of anesthetis often adopting clinically at present, and propofol is the intravenous anesthesia agent of a kind of induction and maintenance anesthesia and calmness, and propofol has rapid induction anesthesia and the quick performance from anesthesia recovery.Although the Comparison of propofol is good, but in using propofol process, the phenomenon that occurs local pain, Blood pressure drop and transience respiratory arrest when injection, sometimes also can cause patient's myoclonus, incidence rate is in 1% left and right, between anesthesia of patient Resuscitation Period, occur feeling sick, vomit and headache phenomenon, in addition propofol agent does not have pain relieving performance, needs to be used in conjunction with analgesic drug product in anaesthesia process, alleviates pain.
In addition in other its constituents of anesthesia product, mostly contain hormone and synthetic medicament, life-time service can bring harm in various degree to human body, therefore, the invention provides a kind of anesthetis that does not add any antiseptic and other hormones, without any murder by poisoning composition, belong to natural pure tcm product, often use and also can not bring injury to human body, simultaneously, can make pipe agent, easy to use, easy to carry, be a kind of desirable local anesthesia product.
Summary of the invention
The invention provides a kind of herbal anesthetic and preparation method; Herbal anesthetic of the present invention has the effect that narcotic analgesic, spasmolytic are only jerked and benumbed muscle, in clinical operation treatment, there is remarkable anaesthetic effect, to also thering is analgesic activity significantly because of the nervous pain causing, easy to use, safe and reliable, without any side effects, can be widely used in the anesthesia procedure of clinical operation medical treatment.
For achieving the above object, technical scheme of the present invention is implemented as follows:
A herbal anesthetic, raw material composition and the parts by weight of making described herbal anesthetic effective ingredient are:
33～63 parts of 39～61 portions of Fructus Gardeniaes of 38～68 parts of fevervines of 43～73 parts of Rhizoma Chuanxiongs of Cortex Ilicis Rotundae
28～58 parts of 28～58 parts of Herba Houttuyniae of 33～63 portions of Herba Menthaes of 33～63 parts of Fructus Atriplicis Sibiricaees of Concha Ostreae (calcined)
24～48 parts of 24～49 portions of jasmines of 26～50 parts of Folium smilacis chinensiss of 29～53 parts of Radix Perillae of Cortex Albiziae
11～35 parts of 15～40 parts of Loess liquid of 19～44 parts of Fructus Papaveris nudicaulis of 25～49 parts of Radix Aconiti Kusnezoffiis of Radix Angelicae Pubescentis.
Raw material composition and the parts by weight of making described herbal anesthetic effective ingredient are:
38～58 parts of 43～59 portions of Fructus Gardeniaes of 43～63 parts of fevervines of 48～68 parts of Rhizoma Chuanxiongs of Cortex Ilicis Rotundae
33～53 parts of 33～53 parts of Herba Houttuyniae of 38～58 portions of Herba Menthaes of 38～58 parts of Fructus Atriplicis Sibiricaees of Concha Ostreae (calcined)
28～44 parts of 28～45 portions of jasmines of 30～46 parts of Folium smilacis chinensiss of 33～49 parts of Radix Perillae of Cortex Albiziae
15～31 parts of 19～36 parts of Loess liquid of 23～40 parts of Fructus Papaveris nudicaulis of 29～45 parts of Radix Aconiti Kusnezoffiis of Radix Angelicae Pubescentis.
Raw material composition and the parts by weight of making described herbal anesthetic effective ingredient are:
43～53 parts of 47～55 portions of Fructus Gardeniaes of 48～58 parts of fevervines of 53～63 parts of Rhizoma Chuanxiongs of Cortex Ilicis Rotundae
38～48 parts of 38～48 parts of Herba Houttuyniae of 43～53 portions of Herba Menthaes of 43～53 parts of Fructus Atriplicis Sibiricaees of Concha Ostreae (calcined)
32～40 parts of 32～40 portions of jasmines of 34～42 parts of Folium smilacis chinensiss of 37～45 parts of Radix Perillae of Cortex Albiziae
19～27 parts of 23～32 parts of Loess liquid of 27～35 parts of Fructus Papaveris nudicaulis of 33～41 parts of Radix Aconiti Kusnezoffiis of Radix Angelicae Pubescentis.
Raw material composition and the parts by weight of making described herbal anesthetic effective ingredient are:
48 parts of 51 portions of Fructus Gardeniaes of 53 parts of fevervines of 58 parts of Rhizoma Chuanxiongs of Cortex Ilicis Rotundae
43 parts of 43 parts of Herba Houttuyniae of 48 portions of Herba Menthaes of 48 parts of Fructus Atriplicis Sibiricaees of Concha Ostreae (calcined)
36 parts of 36 portions of jasmines of 38 parts of Folium smilacis chinensiss of 41 parts of Radix Perillae of Cortex Albiziae
23 parts of 27 parts of Loess liquid of 31 parts of Fructus Papaveris nudicaulis of 37 parts of Radix Aconiti Kusnezoffiis of Radix Angelicae Pubescentis.
A preparation method for herbal anesthetic, comprises following processing step:
(1) Cortex Ilicis Rotundae, fevervine, Fructus Atriplicis Sibiricae, Herba Houttuyniae, Radix Perillae, Radix Aconiti Kusnezoffii and Fructus Papaveris nudicaulis are cleaned, put into container, add the distilled water of 8～10 times of amounts, soak after 5～6 hours, boil 3～4 hours, extract; Again add 6～8 times of amount distilled water, boil 2～3 hours, extract; Finally, add 4～6 times of amount distilled water, heated and boiled 1～2 hour, extracts; Merge three times extracting solution, filter, obtain filtrate, standby;
(2) get Rhizoma Chuanxiong and clean, section is dried, and with yellow wine sprinkling evenly, putting and frying extremely micro-Jiao in pot is degree, and taking-up cools, and grinds into powder, crosses 160 order fine powders, standby;
(3) Concha Ostreae (calcined), Cortex Albiziae and jasmine are dried, and are placed in mortar and grind into powder, cross 200 order fine powders standby;
(4) Loess liquid is decocted to boiling, get the supernatant standby;
(5) Fructus Gardeniae, Herba Menthae, Folium smilacis chinensis and Radix Angelicae Pubescentis are cleaned, immersed 70% the alcohol solution dipping 1～2 hour of 3 times of amounts, heating extraction 3 hours, reclaims ethanol, filter, and the thick paste that at 60 ℃ of simmer down tos, relative density is 1.13～1.17, standby;
(6) above-mentioned steps (1)～(5) prepared filtrate, fine powder, clear liquid and thick paste are mixed, utilize modern advanced pharmacy science and technology, make medicinal liquid, be herbal anesthetic of the present invention.
The property of medicine of the present invention's herbal anesthetic used is as follows:
Cortex Ilicis Rotundae: bitter in the mouth, cold in nature.Heat-clearing and toxic substances removing, dampness removing pain relieving.Cure mainly cold, fever, tonsillitis, laryngopharynx swelling and pain, acute, chronic hepatitis, acute gastroenteritis, gastric and duodenal ulcers, rheumatic arthritis, traumatic injury, burn.Jiangxi < < medical herbs handbook > > carries: " clearing away heat-damp and promoting diuresis, reducing swelling and alleviating pain.The heating that cures cold, tonsillitis, laryngopharynx swelling and pain, acute gastroenteritis, gastric and duodenal ulcers, traumatic injury, rheumatism.Modern medicine study confirmation, Cortex Ilicis Rotundae can be used for suppurative illness (as skin sore and furuncle, cellulitis, deep abscess etc.), upper respiratory tract infection, acute tonsillitis, acute gastroenteritis, bacillary dysentery, burn infection and surgical prophylaxis infection etc.
Rhizoma Chuanxiong: acrid in the mouth, warm in nature; Return liver, gallbladder, pericardium channel.Blood-activating and qi-promoting, wind-expelling pain-stopping.Be used for pacifying nerve, positive wind syndrome of head headache, lump in the abdomen stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.< < Japan hanako materia medica > > carries: " control a wind cutting, all gas, all strains, all blood, mend five kinds of over strain, and strengthening bone and muscle, adjusts many arteries and veins, and broken crux stagnated blood, supports fresh blood, puts on flesh.”
Fevervine: sweet in the mouth, micro-hardship, property is flat.Expelling wind and removing dampness, promoting digestion and removing stagnation, cough-relieving pain relieving.For bones and muscles pain due to rheumatism, traumatic injury, traumatic pain, liver and gall, gastrointestinal angor, icterohepatitis, enteritis, dysentery, dyspepsia, infantile malnutrition, hemoptysis of pulmonary tuberculosis, bronchitis, the leukopenia that radiation reaction causes, pesticide intoxication; Dermatitis is controlled in external, eczema, sore swollen toxin.
Fructus Gardeniae: bitter in the mouth, cold in nature; GUIXIN, lung, tri-jiao channel.Eliminating fire and detoxication, clearing away heat-damp and promoting diuresis, cool the blood dissipate blood stasis.Vexed for calentura, jaundice dark coloured urine, blood strangury and dry pain, heat in blood is told nosebleed, conjunctival congestion and swelling pain, pathogenic fire,toxin and furuncles, infectious hepatitis, traumatic injury, acute toothache; External treatment bruise pain.
Concha Ostreae (calcined): salty in the mouth, cold nature; Enter liver, kidney channel.Suppressing the hyperactive liver and subsiding YANG, tranquillization with heavy prescription, hard masses softening and resolving, restrains astringent or styptic treatment for spontaneous sweating.Cure mainly vertigo and tinnitus, palpitation with fear insomnia, scrofula goiter ， WEIJIA mass in the abdomen.< < Compendium of Materia Medica > > carries: " resolving phlegm and softening hard masses, removing damp-heat stop heart temper pain, under dysentery, and reddish and whitish turbid urine, the hernia that disappears abdominal mass is amassed piece, wart disease tuberculosis." modern medicine study confirmation, Concha Ostreae (calcined) has convergence, calmness, removing toxic substances, analgesic effect, and acidic extraction thing has inhibitory action to poliovirus.
Fructus Atriplicis Sibiricae:, acrid in the mouth, hardship, slightly warm in nature.Suppressing the hyperactive liver resolving depression, promoting blood circulation by removing wind, improving eyesight is antipruritic.Be used for having a headache dizzy, distending pain in the chest and hypochondrium, breast closes acute mastitis, conjunctival congestion cataracta, rubella pruritus.
Herba Menthae: acrid in the mouth, cool in nature; Gui Jing, enters lung, Liver Channel.Dispelling wind and heat pathogens, the clear sharp head, sore-throat relieving rash, soothing the liver circulation of qi promoting.Cure mainly affection due to external wind and heat, headache, laryngopharynx swelling and pain, dyspepsia flatulence, aphtha, toothache, skin ulcer scabies, urticaria, epidemic febrile disease from the beginning of, rubella pruritus, stagnation of QI due to depression of the liver, hypochondriac pain uncomfortable in chest.< < a thousand pieces of gold dietetic therapy > > carries: " moving diabetes." modern medicine confirms, Herba Menthae is the emotion of nervous indignation gently, can improve spirit, make body and mind vigorously pleased, help fall asleep, central nervous system is had to certain assosting effect.
Herba Houttuyniae: acrid in the mouth, cold nature; Enter lung meridian.Heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, inducing diuresis for treating stranguria syndrome.Be used for the treatment of lung abscess, cough due to lung-heat, the diseases such as sore swollen toxin.Modern pharmacological research shows, the Multiple components such as the volatile oil containing in Herba Houttuyniae, houttuynine sodium bisulfite, the various pathogens such as staphylococcus aureus, Diplococcus pneumoniae and influenza virus, leptospira etc. are had to stronger inhibitory action, can strengthen the phagocytic activity of leukocyte and macrophage, improve body immunity.In addition, also have the effect of radiation resistance and enhancing human body immunity function, and without any side effects.
Cortex Albiziae: sweet in the mouth, property is flat, nontoxic; GUIXIN, Liver Channel.Resolving stagnation for tranquilization, promoting blood circulation and detumescence.Cure mainly irritability, melancholy insomnia, lung abscess skin ulcer is swollen, falls and flutters grieved grade for disease.< < detailed outline > > carries: " and blood, detumescence, pain relieving.”
Radix Perillae: acrid in the mouth, warm in nature, nontoxic; Enter lung, spleen two warps.Expelling wind and cold, lowering the adverse-rising QI and dispelling phlegm, and in antiabortive.Cure mainly dizziness, general pain, nasal obstruction watery nasal discharge, cough with dyspnea, septum pectorale drink, costalgia uncomfortable in chest, stomachache is had loose bowels, vomiting during pregnancy, frequent fetal movement.< < Traditional Chinese Medicine in Sichuan will > > carries: " expelling wind, dissipating cold, sending down the abnormal ascending QI eliminates the phlegm.Control cough with dyspnea, chest and diaphragm phlegm retention, dizzy general pain and nasal obstruction watery nasal discharge.”
Folium smilacis chinensis: sweet in the mouth, warm in nature, nontoxic.Cure mainly swelling due to wind, furuncle, toxic swelling, ecthyma, scalds.< < Japan hanako materia medica > > carries: " control swelling due to wind, pain relieving.Flutter damage, malignant boil, with salt, apply." modern medicine study finds that Folium smilacis chinensis has obvious analgesic effect, astriction is also stronger, and can infection control.
Jasmine: acrid in the mouth, sweet, property is flat; GUIXIN, liver, spleen, lung, kidney channel.Removing dampness for regulating stomach, the resolving depression of regulating the flow of vital energy.Cure mainly taste turbid damp and do not change, eat less gastral cavity vexed, diarrhoea or dysentery stomachache.Modern medicine study confirmation, jasmine has the effect of liver heat removing and eyesight improving, makes people's life lengthening, physical and mental health.
Radix Angelicae Pubescentis: acrid in the mouth, hardship, slightly warm in nature; Return liver, kidney, urinary bladder channel.Expelling wind and dampness, dispersing cold for relieving pain.For anemofrigid-damp arthralgia, lumbocrural pain, few cloudy volt wind headache, headache analgesic.According to < < Bencao Tujing > >, carry: " the auxiliary Radix Angelicae Pubescentis of Ramulus Mori, Radix Angelicae Pubescentis is searched wind, dissipating cold pain relieving and blood stasis dispelling; Ramulus Mori wind-damp dispelling and the meridian dredging is walked crosswise extremity.Papillary, treatment anemofrigid-damp arthralgia increased functionality, especially upper limb pain, scapulohumeral periarthritis." modern medicine study confirmation; angelol extract can suppress the external evoked platelet aggregation of ADP; dichloromethane extract has the activity of antagonism calcium channel blocker receptor; the bergapten including, xanthotoxin, isoimperatorin have obvious spasmolysis, has in addition analgesia, calmness, antiinflammatory, antibacterial action.
Radix Aconiti Kusnezoffii: acrid in the mouth, hardship, hot in nature, very toxic.Expelling wind and removing dampness, dispersing cold for relieving pain, opens expectorant detumescence.Cure mainly anemofrigid-damp arthralgia, arthralgia, wind syndrome of head headache, apoplectic dyscinesia, trusted subordinate's cold type of pain, colic of cold type is had a pain, traumatic injury, swelling and pain due to blood stasis, carbuncle of yin nature toxic swelling; External narcotic analgesic.Modern medicine study confirmation, the Radix Aconiti Kusnezoffii alkali that Radix Aconiti Kusnezoffii includes has local anesthesia effect, and can anti-inflammatory analgesic.
Fructus Papaveris nudicaulis: sour in the mouth, puckery, micro-hardship, cool in nature, poisonous; Return lung, kidney, stomach, large intestine channel.The cough-relieving of sword lung, relieving diarrhea with astringents, analgesia.Cure mainly chronic cough and pant, dysentery, has blood in stool, proctoptosis, seminal emission, leukorrhagia, headache, stomachache, dysmenorrhea.The conventional Chinese herbal medicine handbook > > in < < northeast carries: " analgesia, cough-relieving, Dingchuan, antidiarrheal.Control nervous headache, migraine, chronic cough, pants, and dysentery is had blood in stool, seminal emission, menstrual pain, leucorrhea, proctoptosis, acute or chronic gastritis, gastric ulcer, stomachache.”
Loess liquid: sweet in the mouth, cold in nature, enter liver, lung two warps.Heat clearing away, removing toxic substances, and in.Cure mainly heatstroke excessive thirst, dyspeptic vomiting and diarrhea, abdominal distention, dysentery, alimentary toxicosis.< < Bencao Beiyao > > carries: " control that to let out dysentery cold and hot red white, in abdomen, pyretic toxicity angor and worm Qi enter abdomen.”
The present invention compared with prior art, has following beneficial effect:
Herbal anesthetic of the present invention has the effect that narcotic analgesic, spasmolytic are only jerked and benumbed muscle, in clinical operation treatment, there is remarkable anaesthetic effect, to also thering is analgesic activity significantly because of the nervous pain causing, easy to use, safe and reliable, without any side effects, can be widely used in the anesthesia procedure of clinical operation medical treatment.
The specific embodiment
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
The raw material of herbal anesthetic effective ingredient of the present invention forms and weight is:
Cortex Ilicis Rotundae 68g Rhizoma Chuanxiong 63g fevervine 59g Fructus Gardeniae 58g
Concha Ostreae (calcined) 58g Fructus Atriplicis Sibiricae 58g Herba Menthae 53g Herba Houttuyniae 53g
Cortex Albiziae 49g Radix Perillae 46g Folium smilacis chinensis 45g jasmine 44g
Radix Angelicae Pubescentis 45g Radix Aconiti Kusnezoffii 40g Fructus Papaveris nudicaulis 36g Loess liquid 31g.
The preparation method of herbal anesthetic of the present invention, comprises following processing step:
(1) Cortex Ilicis Rotundae, fevervine, Fructus Atriplicis Sibiricae, Herba Houttuyniae, Radix Perillae, Radix Aconiti Kusnezoffii and Fructus Papaveris nudicaulis are cleaned, put into container, add the distilled water of 8～10 times of amounts, soak after 5～6 hours, boil 3～4 hours, extract; Again add 6～8 times of amount distilled water, boil 2～3 hours, extract; Finally, add 4～6 times of amount distilled water, heated and boiled 1～2 hour, extracts; Merge three times extracting solution, filter, obtain filtrate, standby;
(2) get Rhizoma Chuanxiong and clean, section is dried, and with yellow wine sprinkling evenly, putting and frying extremely micro-Jiao in pot is degree, and taking-up cools, and grinds into powder, crosses 160 order fine powders, standby;
(3) Concha Ostreae (calcined), Cortex Albiziae and jasmine are dried, and are placed in mortar and grind into powder, cross 200 order fine powders standby;
(4) Loess liquid is decocted to boiling, get the supernatant standby;
(5) Fructus Gardeniae, Herba Menthae, Folium smilacis chinensis and Radix Angelicae Pubescentis are cleaned, immersed 70% the alcohol solution dipping 1～2 hour of 3 times of amounts, heating extraction 3 hours, reclaims ethanol, filter, and the thick paste that at 60 ℃ of simmer down tos, relative density is 1.13～1.17, standby;
(6) above-mentioned steps (1)～(5) prepared filtrate, fine powder, clear liquid and thick paste are mixed, utilize modern advanced pharmacy science and technology, make medicinal liquid, be herbal anesthetic of the present invention.
Usage and dosage: injection medicament, 15min before operation, extracts medicinal liquid 15～20ml, and patient with general anesthesia is carried out to intravenous injection, for local anesthesia patient infusion operation surrounding skin or histoorgan.
Embodiment 2
The raw material of herbal anesthetic effective ingredient of the present invention forms and weight is:
Cortex Ilicis Rotundae 63g Rhizoma Chuanxiong 58g fevervine 55g Fructus Gardeniae 53g
Concha Ostreae (calcined) 53g Fructus Atriplicis Sibiricae 53g Herba Menthae 48g Herba Houttuyniae 48g
Cortex Albiziae 45g Radix Perillae 42g Folium smilacis chinensis 40g jasmine 40g
Radix Angelicae Pubescentis 41g Radix Aconiti Kusnezoffii 35g Fructus Papaveris nudicaulis 32g Loess liquid 27g.
Herbal anesthetic preparation method processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Embodiment 3
The raw material of herbal anesthetic effective ingredient of the present invention forms and weight is:
Cortex Ilicis Rotundae 58g Rhizoma Chuanxiong 53g fevervine 51g Fructus Gardeniae 48g
Concha Ostreae (calcined) 48g Fructus Atriplicis Sibiricae 48g Herba Menthae 43g Herba Houttuyniae 43g
Cortex Albiziae 41g Radix Perillae 38g Folium smilacis chinensis 36g jasmine 36g
Radix Angelicae Pubescentis 37g Radix Aconiti Kusnezoffii 31g Fructus Papaveris nudicaulis 27g Loess liquid 23g.
Herbal anesthetic preparation method processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Embodiment 4
The raw material of herbal anesthetic effective ingredient of the present invention forms and weight is:
Cortex Ilicis Rotundae 53g Rhizoma Chuanxiong 48g fevervine 47g Fructus Gardeniae 43g
Concha Ostreae (calcined) 43g Fructus Atriplicis Sibiricae 43g Herba Menthae 38g Herba Houttuyniae 38g
Cortex Albiziae 37g Radix Perillae 34g Folium smilacis chinensis 32g jasmine 32g
Radix Angelicae Pubescentis 33g Radix Aconiti Kusnezoffii 27g Fructus Papaveris nudicaulis 23g Loess liquid 19g.
Herbal anesthetic preparation method processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Embodiment 5
The raw material of herbal anesthetic effective ingredient of the present invention forms and weight is:
Cortex Ilicis Rotundae 48g Rhizoma Chuanxiong 43g fevervine 43g Fructus Gardeniae 38g
Concha Ostreae (calcined) 38g Fructus Atriplicis Sibiricae 38g Herba Menthae 33g Herba Houttuyniae 33g
Cortex Albiziae 33g Radix Perillae 30g Folium smilacis chinensis 28g jasmine 28g
Radix Angelicae Pubescentis 29g Radix Aconiti Kusnezoffii 23g Fructus Papaveris nudicaulis 19g Loess liquid 15g.
Herbal anesthetic preparation method processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Clinical data:
1, case selection:
As herbal anesthetic, selection need to be carried out the routine clinical observation of patient 178 of clinical operation treatment, patient is divided into two groups for the treatment of group and matched groups, treatment group 89 examples, wherein male's 46 examples at random, women's 43 examples, 11～60 years old age, 35.5 years old mean age, 28 examples that the state of an illness is slight, moderate 41 examples, severe 20 examples; Matched group 89 examples, male's 44 examples wherein, women's 45 examples, 12～63 years old age, 36.3 years old mean age, 30 examples that the state of an illness is slight, moderate 36 examples, severe 23 examples; Patient's M-F, age differences and the severe extent for the treatment of group and two groups of cases of matched group are basically identical, without significant difference, have comparability.
2, medicament selection:
Treatment group is used herbal anesthetic of the present invention, injection medicament, and 15min before operation, extracts medicinal liquid 15～20ml, for patient with general anesthesia, carries out intravenous injection, for local anesthesia patient infusion operation surrounding skin or histoorgan.
Matched group is used propofol, and intravenous injection, chooses drug dose by patient age, and by specification is used.
3, efficacy determination:
(1) effective: local paralysis and general anesthesia anesthesia significant reaction, painless in operation process, the neural consciousness of patient is without impact.
(2) invalid: local paralysis and general anesthesia are without obviously anesthesia reaction, and in operation process, pain is strong, the neural consciousness of patient is affected completely.
4, result:
Above result demonstration, treatment group herbal anesthetic anaesthetic effect of the present invention is apparently higher than matched group.
Model case is given an example:
1, desolate certain, female, 16 years old, people from Dalian.Patient removes hospital admission because of abdominal pain, through ultrasound diagnosis, be diagnosed as acute appendicitis, need operative treatment at once, to patient's drug test, find that patient all has bad rejection to multiple anaesthetic, rear use herbal anesthetic of the present invention, the injection in first 15 minutes of performing the operation, observe and detect and show that patient all reflects without any rejection this medicine, anaesthetic effect is intact, be applicable to operative treatment, in operation process, patient, without any pain, observes the appearance without any anesthesia sequela to patient clinical after operation.
2, Zeng, man, 25 years old, Ningbo of Zhejiang people.The left lower limb of patient scratches, wound is about 4 centimetres, dark about 1cm, after tentatively stopping blooding, need to further sew up, use herbal anesthetic of the present invention to carry out anaesthetic treatment to operative site, inject and sew up after 15 minutes, painless in operation, perform the operation and patient was observed to anaesthetic effect in latter 2 hours and move back, without any sequela.
3, river, female, 36 years old, people from Lvliang City, Shanxi.There is a lump patient's right breast inner side, need excise.Use herbal anesthetic of the present invention to anaesthetize, after 15 minutes, perform the operation, in operation process, patient, without any pain, postoperative 4 hours, recovers pain.
4, Gong, man, 59 years old, people from Yangzhou, Jiangsu.Patient's waist 4-5 intervertebral disk hernia companion spinal canal stenosis, need carry out Wicresoft's acicular hook and dial loose art treatment.Use herbal anesthetic of the present invention to do anaesthetic treatment, carry out Wicresoft's acicular hook and dial loose art treatment operation after 15 minutes, painless in art, postoperative to patient clinical, observation occurs without any anesthetis side effect.
Claims (5)
1. a herbal anesthetic, is characterized in that: the raw material of making described herbal anesthetic effective ingredient forms and parts by weight are:
33～63 parts of 39～61 portions of Fructus Gardeniaes of 38～68 parts of fevervines of 43～73 parts of Rhizoma Chuanxiongs of Cortex Ilicis Rotundae
28～58 parts of 28～58 parts of Herba Houttuyniae of 33～63 portions of Herba Menthaes of 33～63 parts of Fructus Atriplicis Sibiricaees of Concha Ostreae (calcined)
24～48 parts of 24～49 portions of jasmines of 26～50 parts of Folium smilacis chinensiss of 29～53 parts of Radix Perillae of Cortex Albiziae
11～35 parts of 15～40 parts of Loess liquid of 19～44 parts of Fructus Papaveris nudicaulis of 25～49 parts of Radix Aconiti Kusnezoffiis of Radix Angelicae Pubescentis.
2. a kind of herbal anesthetic according to claim 1, is characterized in that: the raw material of making described herbal anesthetic effective ingredient forms and parts by weight are:
38～58 parts of 43～59 portions of Fructus Gardeniaes of 43～63 parts of fevervines of 48～68 parts of Rhizoma Chuanxiongs of Cortex Ilicis Rotundae
33～53 parts of 33～53 parts of Herba Houttuyniae of 38～58 portions of Herba Menthaes of 38～58 parts of Fructus Atriplicis Sibiricaees of Concha Ostreae (calcined)
28～44 parts of 28～45 portions of jasmines of 30～46 parts of Folium smilacis chinensiss of 33～49 parts of Radix Perillae of Cortex Albiziae
15～31 parts of 19～36 parts of Loess liquid of 23～40 parts of Fructus Papaveris nudicaulis of 29～45 parts of Radix Aconiti Kusnezoffiis of Radix Angelicae Pubescentis.
3. a kind of herbal anesthetic according to claim 1, is characterized in that: the raw material of making described herbal anesthetic effective ingredient forms and parts by weight are:
43～53 parts of 47～55 portions of Fructus Gardeniaes of 48～58 parts of fevervines of 53～63 parts of Rhizoma Chuanxiongs of Cortex Ilicis Rotundae
38～48 parts of 38～48 parts of Herba Houttuyniae of 43～53 portions of Herba Menthaes of 43～53 parts of Fructus Atriplicis Sibiricaees of Concha Ostreae (calcined)
32～40 parts of 32～40 portions of jasmines of 34～42 parts of Folium smilacis chinensiss of 37～45 parts of Radix Perillae of Cortex Albiziae
19～27 parts of 23～32 parts of Loess liquid of 27～35 parts of Fructus Papaveris nudicaulis of 33～41 parts of Radix Aconiti Kusnezoffiis of Radix Angelicae Pubescentis.
4. a kind of herbal anesthetic according to claim 1, is characterized in that: the raw material of making described herbal anesthetic effective ingredient forms and parts by weight are:
48 parts of 51 portions of Fructus Gardeniaes of 53 parts of fevervines of 58 parts of Rhizoma Chuanxiongs of Cortex Ilicis Rotundae
43 parts of 43 parts of Herba Houttuyniae of 48 portions of Herba Menthaes of 48 parts of Fructus Atriplicis Sibiricaees of Concha Ostreae (calcined)
36 parts of 36 portions of jasmines of 38 parts of Folium smilacis chinensiss of 41 parts of Radix Perillae of Cortex Albiziae
23 parts of 27 parts of Loess liquid of 31 parts of Fructus Papaveris nudicaulis of 37 parts of Radix Aconiti Kusnezoffiis of Radix Angelicae Pubescentis.
5. a preparation method for herbal anesthetic as described in claim 1～4 any one, is characterized in that: comprise following processing step:
(1) Cortex Ilicis Rotundae, fevervine, Fructus Atriplicis Sibiricae, Herba Houttuyniae, Radix Perillae, Radix Aconiti Kusnezoffii and Fructus Papaveris nudicaulis are cleaned, put into container, add the distilled water of 8～10 times of amounts, soak after 5～6 hours, boil 3～4 hours, extract; Again add 6～8 times of amount distilled water, boil 2～3 hours, extract; Finally, add 4～6 times of amount distilled water, heated and boiled 1～2 hour, extracts; Merge three times extracting solution, filter, obtain filtrate, standby;
(2) get Rhizoma Chuanxiong and clean, section is dried, and with yellow wine sprinkling evenly, putting and frying extremely micro-Jiao in pot is degree, and taking-up cools, and grinds into powder, crosses 160 order fine powders, standby;
(3) Concha Ostreae (calcined), Cortex Albiziae and jasmine are dried, and are placed in mortar and grind into powder, cross 200 order fine powders standby;
(4) Loess liquid is decocted to boiling, get the supernatant standby;
(5) Fructus Gardeniae, Herba Menthae, Folium smilacis chinensis and Radix Angelicae Pubescentis are cleaned, immersed 70% the alcohol solution dipping 1～2 hour of 3 times of amounts, heating extraction 3 hours, reclaims ethanol, filter, and the thick paste that at 60 ℃ of simmer down tos, relative density is 1.13～1.17, standby;
(6) above-mentioned steps (1)～(5) prepared filtrate, fine powder, clear liquid and thick paste are mixed, utilize modern advanced pharmacy science and technology, make medicinal liquid, be herbal anesthetic of the present invention.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104435503A (en) * | 2014-12-13 | 2015-03-25 | 于全生 | Traditional Chinese medicine anesthetic special for pre-operation and preparation method |
| CN105596761A (en) * | 2016-02-01 | 2016-05-25 | 郑君 | Anesthetic preparation and preparation method thereof |
| CN105920408A (en) * | 2016-06-13 | 2016-09-07 | 刘春光 | Traditional Chinese medicine preparation for local anesthesia and preparation method and application thereof |
| CN106109846A (en) * | 2016-07-04 | 2016-11-16 | 刘海强 | A kind of analgesia Anesthesia medicine thing |
-
2014
- 2014-01-14 CN CN201410016034.XA patent/CN103721006A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104435503A (en) * | 2014-12-13 | 2015-03-25 | 于全生 | Traditional Chinese medicine anesthetic special for pre-operation and preparation method |
| CN105596761A (en) * | 2016-02-01 | 2016-05-25 | 郑君 | Anesthetic preparation and preparation method thereof |
| CN105920408A (en) * | 2016-06-13 | 2016-09-07 | 刘春光 | Traditional Chinese medicine preparation for local anesthesia and preparation method and application thereof |
| CN106109846A (en) * | 2016-07-04 | 2016-11-16 | 刘海强 | A kind of analgesia Anesthesia medicine thing |
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Application publication date: 20140416 |