CN104352709A - Medicine for treating gastric ulcer and preparation method of medicine - Google Patents
Medicine for treating gastric ulcer and preparation method of medicine Download PDFInfo
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Abstract
The invention discloses a medicine for treating a gastric ulcer and a preparation method of the medicine. The medicine is mainly prepared from immature bitter orange, cuttlebone, soapstone, salviae miltiorrhizae, pseudo-ginseng, radix bupleuri, poria cocos, rhizoma picrorhizae, rheum officinale, dandelion, radix paeoniae alba, pericarpium citri reticulatae and bergamot according to a certain weight ratio. The medicine disclosed by the invention has the functions of clearing away heat and toxic materials, arresting bleeding and treating cutaneous pyogenic infection, and tonifying the spleen and reinforcing the stomach, is short in treatment course, quick in curative effect, and free of a toxic or side effect on treatment of the gastric ulcer.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of gastric ulcer and preparation method thereof, belong to the field of Chinese medicines.
Background technology
Gastric ulcer is a kind of common chronic disease, and be mainly in person between twenty and fifty, autumn and winter season is easily sent out, this sick feature be chronic through outbreak with alleviate alternately, painful area under xiphoid-process, center or to the left, more than occurring by 2 hours half an hour after the meal, feed can disappear.At present, western medicine gastric ulcer poor effect, and long-term taking Western medicine has more side effect, therefore, there is very large demand to the Chinese medicine of effectively treating gastric ulcer in people.
Summary of the invention
The present inventor, through research repeatedly and clinical test and checking, finally have found the medicine of effectively treatment gastric ulcer, thus completes the present invention.
Object of the present invention is just to provide a kind of composition of medicine effectively can treating gastric ulcer.
Another object of the present invention just there is provided the preparation method of this composition of medicine.
Medicine of the present invention selects Fructus Aurantii Immaturus, Endoconcha Sepiae, Talcum, Radix Salviae Miltiorrhizae, Radix Notoginseng, Radix Bupleuri, Poria, Rhizoma Picrorhizae, Radix Et Rhizoma Rhei, Herba Taraxaci, the Radix Paeoniae Alba, Pericarpium Citri Reticulatae, Fructus Citri Sarcodactylis, the Radix Astragali, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Ramulus Cinnamomi, Rhizoma Cyperi medicine to combine, made by these drug regimens each efficacy of drugs produce synergism, thus effectively can treat the recurrence of gastric ulcer.Wherein select Fructus Aurantii Immaturus to be because its nature and flavor are bitter, cold, enter spleen, stomach warp, have dispelling the stagnated QI, loose painful abdominal mass, rush down expectorant, the function of removing food stagnancy, controls chest and abdomen swelling and pain, the thoracic obstruction, painful abdominal mass pain, accumulation of phlegm in the hypochondrium, edema, food stagnation, constipation, gastroptosis, uterine prolapse, proctoptosis.Select Endoconcha Sepiae to be that tepor, enters liver, kidney channel, have dehumidifying, antacid because its nature and flavor are salty, hemostasis, the function of sore, treat for stomachache acid regurgitation, tells, is defeated in battle, hematemesis, has blood in stool, bleeding not during menses, amenorrhea due to blood depletion, Fu Tong mass in the abdomen, intermittent fever of deficiency type dysentery, the rotten skin ulcer of the erosion of the vulva.Talcum is selected to be because its nature and flavor are sweet, light, cold, return bladder, lung, stomach warp, have inducing diuresis for treating stranguria syndrome, heat-clearing and toxic substances removing, the function of damp eliminating expelling summer-heat, control pyretic stranguria, stranguria caused by urinary stone, urinate hot puckery pain, heat-damp in summer excessive thirst, damp and hot watery diarrhea, external treatment eczema, eczema, miliaria.Radix Salviae Miltiorrhizae is selected to be that tepor, enters the heart, Liver Channel, have blood circulation and promoting silt, calming heart and tranquilizing mind, evacuation of pus, and the function of pain relieving, controls angina pectoris, menoxenia, dysmenorrhea, and to close, metrorrhagia leukorrhagia ， mass in the abdomen, gathers, abdominal pain due to blood stasis, arthralgia because its nature and flavor are bitter, palpitation with fear sleeplessness, malignant boil toxic swelling.Select Radix Notoginseng to be because its property sweet and slightly bitter taste, temperature, enters liver, stomach, large intestine channel, has hemostasis, dissipating blood stasis, and detumescence, the function of analgesic therapy, controls haematemesis, hemoptysis, and epistaxis is had blood in stool, dysentery, metrorrhagia, mass in the abdomen, puerperal blood faints, and retention of lochia falls and flutters blood stasis, traumatic hemorrhage, carbuncle pain.Select Radix Bupleuri to be that cool, enter liver, gallbladder meridian, have reconciling superficies and interior, soothing the liver, the function of yang invigorating, controls alternate attack of chill and fever, fullness in the chest and hypochondriac pain because its nature and flavor are bitter, bitter taste is deaf, headache and dizziness, malaria, lower sharp proctoptosis, menoxenia, uterine prolapse.Select Poria to be because its property slightly sweet flavor, flat, enter the heart, spleen, lung meridian, have eliminating dampness and diuresis, strengthening the spleen stomach function regulating, the function of mind tranquilizing and the heart calming, control dysuria edema distending pain, phlegm retention cough with dyspnea, the sound of vomiting of vomitting, has loose bowels, seminal emission, stranguria with turbid discharge, and palpitation with fear is forgetful.Rhizoma Picrorhizae is selected to be that have clearing away heat and cooling blood, the function of dampness, controls infantile malnutrition, infantile convulsion, dysentery, consumptive fever hectic fever due to YIN-deficiency, epistaxis, acute catarrhal conjunctivitis, hemorrhoid complicated by anal fistula skin infection because its nature and flavor bitter cold.Radix Et Rhizoma Rhei is selected to be that enter stomach, large intestine, liver footpath, have the poison that purges heat, removing mass is stagnant because its nature and flavor are bitter, cold, the function of clots absorbing blood, control excess-heat constipation, delirium is gone mad, food stagnation feeling of fullness, dysentery from the beginning of, tenesmus, stasis of blood menolipsis Bi ， lumps in the chest and abdomen, time row epidemic disease due to heat pathogen, sudden and violent swelling ophthalmalgia, spits blood, epistaxis, YANG jaundice, edema, stranguria with turbid discharge, urinates red, carbuncle and ulcer toxic swelling, furuncle, burn.Select Herba Taraxaci to be because its property bitter but sweet flavor, cold, enter liver, stomach warp, have heat-clearing and toxic substances removing, the function of diuresis eliminating stagnation, controls acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, urinary tract infection.Select the Radix Paeoniae Alba to be because its nature and flavor picric acid, cool, enter liver, spleen channel, have nourishing blood to suppress the hyperactive liver, pain relieving in slow, yin fluid astringing receives the function of antiperspirant, controls the breast abdomen pain over the hypochondriac region, and dysentery is suffered from abdominal pain, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.Pericarpium Citri Reticulatae is selected to be that temperature, return lung, spleen channel, have regulating qi-flowing for strengthening spleen, the function of drying dampness to eliminate phlegm, controls fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm because its nature and flavor are bitter, pungent.Selecting Fructus Citri Sarcodactylis, different name Fructus Citri Sarcodactylis, Bergamot, is that temperature, enter liver, stomach warp, regulate the flow of vital energy, the function of reducing phlegm, treats for stomachache, and coerces swollen, vomiting, dysphagic, phlegm retention cough with asthma, and can relieve the effect of alcohol because the arduous acid of its nature and flavor.Select the Radix Astragali to be that tepor, enters lung, spleen channel because its nature and flavor are sweet, life defends consolidating superficial resistance with useful, inducing diuresis to remove edema, poison holding, and the function of granulation promoting, controls spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, and carbuncle is not burst or burst and holds back for a long time; Processing the function with there being invigorating middle warmer benefit, controlling internal injury overstrain, diarrhea due to hypofunction of the spleen, proctoptosis, deficiency of vital energy blood prostration, the disease of metrorrhagia and leukorrhagia and all weakness of QI blood deficiency.Select Radix Codonopsis to be because its nature and flavor are sweet, flat, start with, meridian of Foot-TAI YIN edema caused by disorder of QI, have invigorating the spleen and replenishing QI, the function of promoting the production of body fluid, controls weakness of the spleen and stomach, deficiency of both QI and blood, fatigue and lack of strength, and lack of appetite is thirsty, chronic diarrhea, proctoptosis.Select the Rhizoma Atractylodis Macrocephalae to be because its property bitter but sweet flavor, temperature, enters spleen, stomach warp, has spleen reinforcing, stomach reinforcing, dampness, and in function, control deficient QI of the spleen and stomach, anorexia, asthenia weak breath, deficiency-distension, has loose bowels, phlegm retention, edema, jaundice, arthralgia chiefly caused by damp pathogen, dysuria, dizzy, spontaneous perspiration, and nausea is uneasy.Select Ramulus Cinnamomi to be because its property acrid-sweet flavor, temperature, enter bladder, the heart, lung meridian, have diaphoresis expelling pathogenic factors from muscles, the function of warming the meridian and promoting blood circulation, controls exterior syndrome due to wind-cold, shoulder back of the body podomere ache, thoracic obstruction phlegm retention, amenorrhea and mass in the abdomen.Rhizoma Cyperi is selected to be because the pungent micro-hard work of its nature and flavor, flat, enter liver, tri-jiao channel, resolving depression of regulating the flow of vital energy, the function of pain relieving regulating menstruation, treating the liver discomfort in the stomach, depression of QI, breast abdomen distending pain over the hypochondrium, phlegm retention feeling of fullness, menoxenia, bleeding not during menses.
The drug dose of the present invention's combination is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight:
Fructus Aurantii Immaturus 15-20 gram of Endoconcha Sepiae 15-20 gram of Talcum 15-20 gram
Radix Salviae Miltiorrhizae 15-20 gram of Radix Notoginseng 6-8 gram of Radix Bupleuri 6-8 gram
Poria 6-8 KEHU Rhizoma Coptidis 6-8 gram of Radix Et Rhizoma Rhei 6-8 gram
Herba Taraxaci 8-10 gram of Radix Paeoniae Alba 8-10 gram of Pericarpium Citri Reticulatae 8-10 gram
Fructus Citri Sarcodactylis 8-10 gram of Radix Astragali 10-15 gram of Radix Codonopsis 10-15 gram
Rhizoma Atractylodis Macrocephalae 10-15 gram of Ramulus Cinnamomi 10-15 gram of Rhizoma Cyperi 10-15 gram
Preferable amount is:
17 grams, Fructus Aurantii Immaturus 17 grams of Endoconcha Sepiaes 17 grams of Talcums
Radix Salviae Miltiorrhizae 17 grams of Radix Notoginseng 7 grams of Radix Bupleuri 7 grams
Poria 7 KEHU Rhizoma Coptidis 7 grams of Radix Et Rhizoma Rhei 7 grams
Herba Taraxaci 9 grams of Radix Paeoniae Albas 9 grams of Pericarpium Citri Reticulataes 9 grams
Fructus Citri Sarcodactylis 9 grams of Radixs Astragali 13 grams of Radix Codonopsis 13 grams
The Rhizoma Atractylodis Macrocephalae 13 grams of Ramulus Cinnamomi 13 grams of Rhizoma Cyperis 13 grams
The preparation method of medicine of the present invention is as follows:
One, get the raw materials ready
1, Fructus Aurantii Immaturus: pick clean impurity, be soaked in water to eighty per cant thoroughly, pull out, profit, to interior without hard-core, cut into slices, is dried;
2, Endoconcha Sepiae: scrub clean, dries, and pounds into fritter;
3, Talcum: get crude drug, removing impurity, cleaning, drying;
4, Radix Salviae Miltiorrhizae: pick clean impurity, removing rhizome, cleans, pulls out, run through rear section, dry;
5, Radix Notoginseng: pick clean impurity, smash to pieces, grinds or runs through rear section into powder and dry;
6, Radix Bupleuri: pick decontamination, removes residual stem, cleans silt, pulls out, run through rear timely section, dry immediately;
7, Poria: be soaked in water, cleans and pulls out, and after vexed, section, dries;
8, Rhizoma Picrorhizae: pick decontamination, wash in a pan with clear water clean, pick up and run through, section, dries;
9, Radix Et Rhizoma Rhei: pick clean impurity, size stepping, stews to moisten to inside and outside humidity even, cuts into slices or is cut into small pieces, dries;
10, Herba Taraxaci: pick decontamination, clean earth, cutting, dries;
11, the Radix Paeoniae Alba: pick decontamination, separately size, be soaked in water to eighty per cant thoroughly, pull out, solarization is dried in the air, section, dry;
12, Pericarpium Citri Reticulatae: get crude drug, the peel of removing impurity and blackening, wash quickly is clean, softens, shredding, dries or cold drying, sieve dedust bits;
13, Fructus Citri Sarcodactylis: pick decontamination, after water spray profit, chopping, dries;
14, the Radix Astragali: pick clean impurity, the root head that removing is residual and hollow larger root, be soaked in water, pull out, run through rear section and dry;
15, Radix Codonopsis: run through reed after cleaning silt, section or cutting, dry;
16, the Rhizoma Atractylodis Macrocephalae: pick clean impurity, be soaked in water, pull out after bubble, run through, section, dries;
17, Ramulus Cinnamomi: slightly soak with water, pulls out, and moistening, to thoroughly, is cut into slices, dried, sieve anti-dandruff;
18, Rhizoma Cyperi: pick decontamination, is ground into particle, winnow with a dustpan fine, soft fur and smalls.
Two, prepare
1, by the Fructus Aurantii Immaturus of described weight, Endoconcha Sepiae, Talcum, Radix Salviae Miltiorrhizae, Radix Notoginseng, Radix Bupleuri, Poria, Rhizoma Picrorhizae, Radix Et Rhizoma Rhei, Herba Taraxaci, the Radix Paeoniae Alba, Pericarpium Citri Reticulatae, Fructus Citri Sarcodactylis, the Radix Astragali, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Ramulus Cinnamomi, Rhizoma Cyperi drug decocting secondary, add water 8 times amount for the first time, soak after 90 minutes, intense fire decocts boiling 10 minutes, then within 30 minutes, filters to obtain decoction liquor for the first time with slow fire boiling.
2, add water the medicinal residues of filtration 6 times amount, first boils with high heat, then use slow fire boiling 30 minutes, filters to obtain second time decoction liquor.
3, by twice decoction liquor mixing and stirring, obtain medicinal liquid, medicinal liquid is divided into 3 doses and takes.
The present invention selects Fructus Aurantii Immaturus to be monarch drug, and Rhizoma Picrorhizae, Radix Et Rhizoma Rhei are ministerial drug, and Poria is assistant, and said medicine and all medicines, for making, are combined the medicine made and treat gastric ulcer by the Rhizoma Atractylodis Macrocephalae.
Medicine of the present invention has heat-clearing and toxic substances removing, arresting bleeding and healing up ulcer, and the function of spleen reinforcing stomach reinforcing, is used for the treatment of gastric ulcer, short treating period, instant effect, non-relapse after healing, has no side effect.
Detailed description of the invention:
Set forth the beneficial effect of medicine of the present invention further below by way of test example, these test examples comprise animal toxicity test report and the clinical observation on the therapeutic effect data of medicine of the present invention.
The animal toxicity test report of [test example 1] medicine of the present invention:
Get rabbit 30, male and female dual-purpose, body weight 2.0-2.5kg, divide two groups, often organize 15, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, and every day, secondary, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.
The clinical observation material of [test example 2] Drug therapy gastric ulcer of the present invention:
1, physical data
Accept out-patient's totally 42 examples for medical treatment.
2, diagnostic criteria
Clinical manifestation: epigastrium pain, under being positioned at xiphoid-process (pit of the stomach) or around epigastrium center line, in burning property, nibbling property or inanition dull pain, distending pain or dull pain.But be sometimes also only confined to bottom, thoracic cavity.Pain can continue half an hour by three hours after occurring.Disappear when sending out during fitful pain, after the intermittent pain of lasting several weeks, there will be one period of of short duration painless phase.This pain is relevant with diet, often because of hungry, take medicine, acidic food or beverage and bring out.Pain can be alleviated because taking food, drinking water, take base-forming food (as steamed bread).Other symptoms may be heartburn, acid regurgitation water, belch, loss of appetite, lose weight, anemia, to vomit once in a while, and pain will be made after vomiting to relax, and black or pitch sample are defecated.
3, Therapeutic Method
Select above-mentioned medicament, take to patient, each serving with 1 dose, every day early, evening respectively takes 1 time, within 10 days, is a course for the treatment of, takes 3 courses for the treatment of continuously.
4, efficacy assessment standard
Effective: gastric ulcer transference cure, recovery from illness, body constitution recovers normal, observes half a year without recidivist;
Take a turn for the better: gastric ulcer symptom is clearly better, and abdominal pain alleviates, appetite is normal, and body constitution is progressively recovered;
Invalid: not reach improvement standard person.
5, therapeutic outcome (seeing the following form)
In above-mentioned treatment, by Drug therapy patients w ith peptic ulcer disease 42 example of the present invention, effective 34 examples of result, obvious effective rate is 80.95%, and take a turn for the better 6 examples, and improvement rate is 14.29%, and invalid 2 examples, total effective rate is 95.24%.
Claims (3)
1. treat a medicine for gastric ulcer, it is characterized in that: it is made up of the crude drug in following weight range:
Fructus Aurantii Immaturus 15-20 gram of Endoconcha Sepiae 15-20 gram of Talcum 15-20 gram
Radix Salviae Miltiorrhizae 15-20 gram of Radix Notoginseng 6-8 gram of Radix Bupleuri 6-8 gram
Poria 6-8 KEHU Rhizoma Coptidis 6-8 gram of Radix Et Rhizoma Rhei 6-8 gram
Herba Taraxaci 8-10 gram of Radix Paeoniae Alba 8-10 gram of Pericarpium Citri Reticulatae 8-10 gram
Fructus Citri Sarcodactylis 8-10 gram of Radix Astragali 10-15 gram of Radix Codonopsis 10-15 gram
Rhizoma Atractylodis Macrocephalae 10-15 gram of Ramulus Cinnamomi 10-15 gram of Rhizoma Cyperi 10-15 gram.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
17 grams, Fructus Aurantii Immaturus 17 grams of Endoconcha Sepiaes 17 grams of Talcums
Radix Salviae Miltiorrhizae 17 grams of Radix Notoginseng 7 grams of Radix Bupleuri 7 grams
Poria 7 KEHU Rhizoma Coptidis 7 grams of Radix Et Rhizoma Rhei 7 grams
Herba Taraxaci 9 grams of Radix Paeoniae Albas 9 grams of Pericarpium Citri Reticulataes 9 grams
Fructus Citri Sarcodactylis 9 grams of Radixs Astragali 13 grams of Radix Codonopsis 13 grams
The Rhizoma Atractylodis Macrocephalae 13 grams of Ramulus Cinnamomi 13 grams of Rhizoma Cyperis 13 grams.
3. the preparation method of medicine according to claim 1 or 2, is characterized in that: it comprises the following steps:
One, get the raw materials ready
1, Fructus Aurantii Immaturus: pick clean impurity, be soaked in water to eighty per cant thoroughly, pull out, profit, to interior without hard-core, cut into slices, is dried;
2, Endoconcha Sepiae: scrub clean, dries, and pounds into fritter;
3, Talcum: get crude drug, removing impurity, cleaning, drying;
4, Radix Salviae Miltiorrhizae: pick clean impurity, removing rhizome, cleans, pulls out, run through rear section, dry;
5, Radix Notoginseng: pick clean impurity, smash to pieces, grinds or runs through rear section into powder and dry;
6, Radix Bupleuri: pick decontamination, removes residual stem, cleans silt, pulls out, run through rear timely section, dry immediately;
7, Poria: be soaked in water, cleans and pulls out, and after vexed, section, dries;
8, Rhizoma Picrorhizae: pick decontamination, wash in a pan clean with clear water, pick up and run through, section is dried;
9, Radix Et Rhizoma Rhei: pick clean impurity, size stepping, stews to moisten to inside and outside humidity even, cuts into slices or is cut into small pieces, dries;
10, Herba Taraxaci: pick decontamination, clean earth, cutting, dries;
11, the Radix Paeoniae Alba: pick decontamination, separately size, be soaked in water to eighty per cant thoroughly, pull out, solarization is dried in the air, section, dry;
12, Pericarpium Citri Reticulatae: get crude drug, the peel of removing impurity and blackening, wash quickly is clean, softens, shredding, dries or cold drying, sieve dedust bits;
13, Fructus Citri Sarcodactylis: pick decontamination, after water spray profit, chopping, dries;
14, the Radix Astragali: pick clean impurity, the root head that removing is residual and hollow larger root, be soaked in water, pull out, run through rear section, dry;
15, Radix Codonopsis: run through reed after cleaning silt, section or cutting, dry;
16, the Rhizoma Atractylodis Macrocephalae: pick clean impurity, be soaked in water, pull out after bubble, run through, section, dries;
17, Ramulus Cinnamomi: slightly soak with water, pulls out, and moistening, to thoroughly, is cut into slices, dried, sieve anti-dandruff;
18, Rhizoma Cyperi: pick decontamination, is ground into particle, winnow with a dustpan fine, soft fur and smalls,
Two, prepare
1, by the Fructus Aurantii Immaturus of described weight, Endoconcha Sepiae, Talcum, Radix Salviae Miltiorrhizae, Radix Notoginseng, Radix Bupleuri, Poria, Rhizoma Picrorhizae, Radix Et Rhizoma Rhei, Herba Taraxaci, the Radix Paeoniae Alba, Pericarpium Citri Reticulatae, Fructus Citri Sarcodactylis, the Radix Astragali, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Ramulus Cinnamomi, Rhizoma Cyperi drug decocting secondary, add water 8 times amount for the first time, soak after 90 minutes, intense fire decocts boiling 10 minutes, use slow fire boiling again 30 minutes, filter first time decoction liquor
2, add water the medicinal residues of filtration 6 times amount, first boils with high heat, then use slow fire boiling 30 minutes, filters to obtain second time decoction liquor,
3, by twice decoction liquor mixing and stirring, medicinal liquid is obtained.
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| CN104958487A (en) * | 2015-07-25 | 2015-10-07 | 王璐 | Traditional Chinese medicine for treating gastrointestinal ulcer |
| CN105343800A (en) * | 2015-12-14 | 2016-02-24 | 陈如燕 | Traditional Chinese medicine preparation for curing gastric ulcer and preparation method thereof |
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