CN104274668A - Medicine for treating migraine - Google Patents
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract
The invention relates to the field of pharmaceutical formulations and in particular relates to a medicine for treating migraine. The medicine is characterized by being prepared from the following raw material medicines in percentage by weight: 8-11 percent of marasmius androsaceus, 7-10 percent of sweet basil, 6-9 percent of botrychiam ternatum, 5-8 percent of Pinellia ternate, 8-12 percent of notopterygium root, 7-11 percent of philippine flemingia root, 5-8 percent of ponceau, 6-10 percent of flower of fragrant plantain lily, 5-7 percent of eupatorium chinense, 5-8 percent of Pink Reineckea Herb, 2-5 percent of Clerodendrum japonicum leaves, 2-4 percent of oriental paperbush flower, 2-5 percent of Salvia cavaleriei, 2-3 percent of Chinese Tamarisk Twig and 5-7 percent of Japanese ardisia. The preparation method comprises the following steps: soaking the fifteen raw material medicines by using water, decocting, and removing the decoction dregs, thereby obtaining the filtrate. The medicine disclosed by the invention has the effects of expelling wind and removing cold, invigorating spleen and replenishing qi and relaxing the muscles and stimulating the blood circulation and has obvious curative effects on symptoms such as nausea and emesis caused by migraine. Moreover, the traditional Chinese medicine preparation is easy to prepare, convenient to take, short in course of treatment, fast in effectiveness, safe and low in cost and does not have any toxic or side effect, and the migraine does not reoccur after healing.
Description
Technical field
The present invention relates to technical field of Chinese patent medicine, specifically one is used for the treatment of migrainous medicine.
Background technology
As everyone knows, migraine is the headache of a kind of common repeated relapsing with symptoms such as Nausea and vomiting, photophobia, phonophobias.Patient's main clinical manifestation is head side or bilateral distending pain, in beating or rest pain, periodical attack, unilateral headache during outbreak, and sharp ache sometimes, tool pulsation, sometimes with nausea and vomiting, or photophobia, phonophobia, this headache is usually from eye socket or frons, to half expansion, also can throughout whole head, its sickness rate is up to 8.4% ~ 28%.With the quickening pace of modern life with the increase of operating pressure, migraine has presented the trend constantly risen at the sickness rate of China, become the commonly encountered diseases of puzzlement modern, migraine is vascular headache the most common clinically, present the throbbing pain consistent with pulsation or distending pain, bowing firmly cough etc. of being heated all can make headache increase the weight of, and shows effect in acute recurrent.
The migrainous medicament categories of current treatment is a lot, and great majority western medicine, though this kind of medicine can alleviate disease to a certain extent, but cure the symptoms, not the disease, usually need Long-term taking medicine, just get back to the original state of an illness again once drug withdrawal, if inappropriate medication, also may fail to respond to any medical treatment and even increase the weight of disease.
Summary of the invention
Object of the present invention is exactly to overcome above-mentioned existing technical deficiency, provides one to treat migrainous medicine, has expelling wind and cold, invigorating the spleen and replenishing QI, effect of relaxing muscles and tendons to promote blood circulation, have significant curative effect for symptoms such as the Nausea and vomiting that migraine causes; Chinese medicine preparation preparation of the present invention is simple, taking convenience, short treating period, instant effect, and safe without toxic side effect is with low cost, does not recur more.
The technical scheme that the present invention solves the problems of the technologies described above employing is: one treats migrainous medicine, it is characterized in that being made up of the crude drug of following percentage by weight: Marasmius equicrinis Muell. 8 ~ 11%, Herba Ocimi (Herba Ocimi Pilosi) 7 ~ 10%, Herba Botrychii 6 ~ 9%, fiber crops taro 5 ~ 8%, Rhizoma Et Radix Notopterygii 8 ~ 12%, Radix Flemingiae Philippinensis 7 ~ 11%, Flos Papaveris rhoeadis 5 ~ 8%, Flos Hostae Plantagineae 6 ~ 10%, Herba Serissae 5 ~ 7%, Herba Reineckeae Carneae 5 ~ 8%, Folium Clerodendri japonici 2 ~ 5%, flowers of Edgeworthia chrysantha Lindl 2 ~ 4%, Salvia cavaleriei 2 ~ 5%, Cacumen Tamaricis 2 ~ 3%, PINGDIMU 5 ~ 7%, above-mentioned 15 taste crude drug are soaked in water, to remove slag after decocting to obtain filtrate.
The invention has the beneficial effects as follows that there is expelling wind and cold, invigorating the spleen and replenishing QI, effect of relaxing muscles and tendons to promote blood circulation, for symptoms such as the Nausea and vomiting that migraine causes, there is significant curative effect; Chinese medicine preparation preparation of the present invention is simple, taking convenience, short treating period, instant effect, and safe without toxic side effect is with low cost, does not recur more.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described:
Embodiment 1:
Marasmius equicrinis Muell., Herba Ocimi (Herba Ocimi Pilosi), Herba Botrychii, numb taro, Rhizoma Et Radix Notopterygii, Radix Flemingiae Philippinensis, Flos Papaveris rhoeadis, Flos Hostae Plantagineae, Herba Serissae, Herba Reineckeae Carneae, Folium Clerodendri japonici, flowers of Edgeworthia chrysantha Lindl, Salvia cavaleriei, Cacumen Tamaricis, PINGDIMU is adopted to be that crude drug is prepared from.Its component (% by weight) is often paid and is: Marasmius equicrinis Muell. 9.1, Herba Ocimi (Herba Ocimi Pilosi) 8.3, Herba Botrychii 7.5, numb taro 7.5, Rhizoma Et Radix Notopterygii 8.9, Radix Flemingiae Philippinensis 8.7, Flos Papaveris rhoeadis 6.8, Flos Hostae Plantagineae 8.9, Herba Serissae 6.8, Herba Reineckeae Carneae 7.1 Folium Clerodendri japonici 4.5, flowers of Edgeworthia chrysantha Lindl 3.1, Salvia cavaleriei 3.7, Cacumen Tamaricis 2.3, PINGDIMU 6.8.Getting above-mentioned 15 kinds of raw material gross weights is 181 grams, at room temperature 15 kinds of Chinese herbal medicine are added water to 800 ~ 1000ml, soak 3 ~ 5 minutes, then boil slow fire with high heat and decoct about 90 ~ 100 minutes, remove slag to obtain filtrate 200ml, and medicinal residues add water 250 ~ 300ml again, decoct 30 ~ 40 minutes, remove slag to obtain filtrate 100ml, is total to obtain about 300ml medicine juice, i.e. obtained Chinese medicine decoction of the present invention.Load in sterile glass vials, seal bottle cap is for subsequent use, and every day 1 dose point 2 times is oral, oral about the 150ml of each empty stomach, takes to Clinical symptom and sign and disappears.
Marasmius equicrinis Muell. of the present invention is invigorated blood circulation analgesic therapy.Main traumatic injury, fracture pain, migraine, various neuralgia, lumbago and skelalgia, rheumatic arthralgia; Herba Ocimi (Herba Ocimi Pilosi) has dispelling wind circulation of qi promoting, and removing dampness helps digestion, the function of invigorating blood circulation, detoxifying.For controlling of the diseases such as headache due to invasion of exogenous pathogens, the flatulence due to improper diet stagnation of QI, urticaria sufferings; Herba Botrychii heat-clearing and toxic substances removing, suppressing the hyperactive liver to relieve the wind syndrome, cough-relieving, hemostasis, improving eyesight removing nebula, controls dizzy headache, is monarch drug altogether; Fiber crops taro drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.For abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, interior expectorant is dizzy, syncope due to accumulation of phlegm is had a headache, vomit regurgitation, breast gastral cavity painful abdominal mass is vexed; Rhizoma Et Radix Notopterygii is used for affection of exogenous wind-cold, have a headache lossless, cold-damp numbness, upper limb rheumatalgia, and two tastes help monarch, are ministerial drug altogether; Help with Radix Flemingiae Philippinensis, Flos Papaveris rhoeadis, Radix Flemingiae Philippinensis expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral, bone and muscle strengthening, anti-inflammatory analgetic; Flos Papaveris rhoeadis has another name called Flos Papaveris rhoeadis, has cough-relieving, pain relieving, stops letting out, the effect of hypnosis; Flos Hostae Plantagineae profit has the merit of clearing heat for detumescence, removing toxic substances pain relieving; Herba Serissae heat-clearing and toxic substances removing, sore-throat relieving reduces phlegm.For diphtheria, tonsillitis, pharyngolaryngitis, cold, fever, measles, pneumonia, bronchitis, rheumatic arthritis, carbuncle furuncle and phyma poison, venom; Herba Reineckeae Carneae has nourishing the lung to arrest cough, reinforces the kidney, effect of synthetism; Folium Clerodendri japonici has detumescence dissipating blood stasis effect, can control carbuncle furuncle, traumatic injury; Flowers of Edgeworthia chrysantha Lindl yin nourishing is calmed the nerves, and improving eyesight is dispelled and hidden from view.For optic atrohic blindness, cataracta, many tear, nocturnal emission, empty pouring, aphonia; Salvia cavaleriei, cures mainly haematemesis, metrorrhagia , Nv blood, and knife injury is hemorrhage, dysentery, trembles with fear puerperal and waits disease; Cacumen Tamaricis treatment of smallpox rash is thoroughly sent out smooth or measles toxin and is caved in, flu, cough, rheumatic ostalgia; PINGDIMU has preventing phlegm from forming and stopping coughing, dampness removing, the effect of invigorating blood circulation, altogether for making medicine.
The each raw material of the present invention also can the embodiment that mixes of ratio (percentage by weight) listed by according to the form below realize.Its processing technique is identical with embodiment 1.
The clinical trial carried out below in conjunction with my institute is done further the present invention, is described in detail:
Case selection: select migraineur 150 example made a definite diagnosis, wherein male 78 example, women 72 example, 20 ~ 40 years old age, 30.7 years old mean age, the shortest person of the course of disease 3 months, most elder 13 years, average 6.5 years.
Therapeutic Method: every day 1 dose point 2 times is oral, and each oral about 150ml on an empty stomach, 10 days be a course for the treatment of, each course for the treatment of, every three days, takes three courses for the treatment of of the present invention continuously.
Therapeutic evaluation:
Cure: headache and simultaneous phenomenon disappear, and sign is improved completely.Effective: headache and simultaneous phenomenon disappear substantially, feature is improved obviously.Effective: Headache attacks degree and simultaneous phenomenon alleviate to some extent, and feature makes moderate progress.Invalid: headache and simultaneous phenomenon and feature are all without improving.
Therapeutic effect: cure 62 examples, effective 54 examples, effective 31 examples, invalid 3 examples, cure rate 41.3%, total effective rate 98%.
Model case:
Wang, female, 21 years old, to suffer from the right side of paroxysmal migraine 3 months, often vexed, dreaminess.Admission examination, white and greasy fur is thicker, lustreless complexion, and thready pulse chi is soft, blood pressure 145/105mmHg, and once took multi-medicament treatment, therapeutic effect is very poor, easily repeatedly.To our hospital afterwards, take medicine of the present invention, after taking 2 courses for the treatment of, symptom disappears substantially, and after taking the 3rd course for the treatment of, migraine is cured, and follows up a case by regular visits to, do not recur after 1 year.
Song, female, 36 years old, patient had a headache 6 years, and based on left side temple, jumping pain, comparatively serious during sleep difference, monthly pain 3 ~ 4 times, has persistence.Admission examination, finds patient's fever sensation of the face, dark tongue quality, and body is large, and tongue is white, stringy pulse.After taking 1 course for the treatment of of Chinese medicine preparation of the present invention, headache is not sent out, time have fever sensation of the face, sleep also take a favorable turn, but still has dark tongue quality, and tongue is white, the symptoms such as stringy pulse, and after continuing to take 1 course for the treatment of of Chinese medicine preparation of the present invention, headache disappears, and follows up a case by regular visits to, do not recur after half a year.
Clump certain, man, 44 years old, patient had a headache 2 years, and pain is twinge, and with the symptom such as sweating, bitter taste, flushing, thirsty, dark tongue quality, tongue is white, body is bigger, deep and stringy pulse, after taking 1 course for the treatment of of Chinese medicine preparation of the present invention, headache alleviates, and perspires few, ponder over, red tongue, tongue white spirit, deep and stringy pulse; After continuing to take 2 courses for the treatment of of Chinese medicine preparation of the present invention, headache and all kinds of transference cure, follow up a case by regular visits to, do not recur so far.
Claims (1)
1. the migrainous medicine for the treatment of, it is characterized in that being made up of the crude drug of following percentage by weight: Marasmius equicrinis Muell. 8 ~ 11%, Herba Ocimi (Herba Ocimi Pilosi) 7 ~ 10%, Herba Botrychii 6 ~ 9%, numb taro 5 ~ 8%, Rhizoma Et Radix Notopterygii 8 ~ 12%, Radix Flemingiae Philippinensis 7 ~ 11%, Flos Papaveris rhoeadis 5 ~ 8%, Flos Hostae Plantagineae 6 ~ 10%, Herba Serissae 5 ~ 7%, Herba Reineckeae Carneae 5 ~ 8%, remit Folium paulowniae 2 ~ 5%, flowers of Edgeworthia chrysantha Lindl 2 ~ 4%, Salvia cavaleriei 2 ~ 5%, Cacumen Tamaricis 2 ~ 3%, PINGDIMU 5 ~ 7%, above-mentioned 15 taste crude drug are soaked in water, filtrate of removing slag after decocting to obtain.
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CN201410588265.8A CN104274668A (en) | 2014-10-15 | 2014-10-15 | Medicine for treating migraine |
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CN201410588265.8A CN104274668A (en) | 2014-10-15 | 2014-10-15 | Medicine for treating migraine |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN107982403A (en) * | 2018-01-18 | 2018-05-04 | 王慧玲 | Treat the medicine of antimigraine |
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CN103520555A (en) * | 2013-10-27 | 2014-01-22 | 周文华 | Drug for treatment of migraine |
CN103536778A (en) * | 2013-11-05 | 2014-01-29 | 王彦贞 | Traditional Chinese medicine preparation for treating cephalagra |
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2014
- 2014-10-15 CN CN201410588265.8A patent/CN104274668A/en active Pending
Patent Citations (2)
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CN103520555A (en) * | 2013-10-27 | 2014-01-22 | 周文华 | Drug for treatment of migraine |
CN103536778A (en) * | 2013-11-05 | 2014-01-29 | 王彦贞 | Traditional Chinese medicine preparation for treating cephalagra |
Non-Patent Citations (3)
Title |
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朱广媛: "《名医名方精华辑要》", 31 August 2013, 黑龙江科学技术出版社 * |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN107982403A (en) * | 2018-01-18 | 2018-05-04 | 王慧玲 | Treat the medicine of antimigraine |
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Application publication date: 20150114 |