CN104622920A - Pharmaceutical composition for promoting healing of skin wound and preparation method thereof - Google Patents
Pharmaceutical composition for promoting healing of skin wound and preparation method thereof Download PDFInfo
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- CN104622920A CN104622920A CN201510030993.1A CN201510030993A CN104622920A CN 104622920 A CN104622920 A CN 104622920A CN 201510030993 A CN201510030993 A CN 201510030993A CN 104622920 A CN104622920 A CN 104622920A
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- pharmaceutical composition
- petroleum ether
- wound healing
- myrianthae
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Abstract
The invention discloses a pharmaceutical composition for promoting the healing of a skin wound and a preparation method thereof. The composition is prepared from an active component and a pharmaceutically acceptable auxiliary material, wherein the active component is a petroleum ether position extract of a goldhair hedyotis herb raw material. The pharmaceutical composition disclosed by the invention is prepared by extracting a single traditional Chinese medicinal material, few in raw materials, good in effect, capable of obviously promoting the healing of a scald wound surface and better than other medicines at the aspects of shortening the escharosis time and reducing the scar area, and has the advantages of being short in treatment course, quick in effect, good in treatment effect and the like.
Description
Technical field
The invention belongs to medical art, in particular to a kind of pharmaceutical composition promoting skin wound healing and preparation method thereof.
Background technology
In daily life, the skin burn that accidentally causes because taking action or scald often can occur, the lighter's pain is rubescent, severe one is bubbled, and even exfoliation is downright bad, hinders to bone.As cured not in time, pathogenic factor and antibacterial invade, and not only can expand wound surface, skin ulceration, even cause infection, produce septicemia, cause death.At present, costly, treatment cycle is long for burn and scald, dermopathic western medical treatment, the difficulty and the burn and scald in rural area, dermatosis patient are sought medical advice, and process will scar not in time.Wound healing process of tissue reparation is realized by mutual network-linkeds of several basic link (key element) such as inflammatory cell reaction, repair cell reaction, extracellular matrix reaction and cytokine (somatomedin) effects.Empyrosis wound surface weakens due to inflammatory reaction, and cell proliferation is suppressed, and growth factor expression reduces, extracellular matrix habituation, local organization hypoxic-ischemic, the factors such as traumatic part accompanying infection, hemorrhage, edema, and the wound healing that slows down.
Astilbe myriantha Diels, saxifragaceae plant, Latin plant animal mineral name Astilbe rivularis Buch.-Ham.ex D.Don var.myriantha (Diels) J.T.Pan [A.myriantha Diels], perennial herb, high 60-150cm.Herb has short glandular hair, near without hair time old.Rhizome is sturdy, is irregular bar shaped, raw most fibrous root.Stem's brown gland shape pubescence.Basal leaf is go out winglike compound leaf two to three times three, tool long handle; Avette or the width egg shape of lobule to oblong, long 25-15cm, wide 1.5-8.5cm, tip is gradually sharp, and base portion is heart-shaped, and there is heavy sawtooth at edge, below have undercoat along the pulse.Panicle, long 40-60cm, close raw pubescence and glandular hair; Bract bores shape, shorter than calyx; Flower both sexes or unisexuality, dioecism; Calyx white, long 1-1.8mm, 5 drastic cracks, sliver is narrow avette; Petal without or sometimes have a 1(-2-5) piece degeneration petal; Stamen 7-10; Carpel 2, from life.Follicle radish fruit, is about 4mm.The flowering fruit bearing stage 7-10 month.Be born in the hillside of height above sea level 1100-2500m, sylvan life, shrubbery and cheuch the moon place, be distributed in the ground such as Shaanxi, Henan, Hubei, Sichuan, Gansu, Guizhou, Tibet.
The rhizome of astilbe myriantha Diels is irregular lumps or Long Circle, is about 6cm, diameter 1-2cm.Surface sepia or pitchy, shrinkage, has transverse corrugations stricture of vagina, tool brown fine hair and most mark of fibrous root or remaining radicula; Stem foot has most gland shape pubescence and scale above.Matter is crisp, frangibility, section mealiness, brownish red.Feeble QI is acrid in the mouth, micro-puckery.At present, the rhizome of astilbe myriantha Diels is in the news and has expelling pathogenic wind from the body surface, analgesic biological activity, and for Common Cold after main oral administration, headache, migrainous treatment, has the effect promoting skin wound healing after there is no its external of bibliographical information.
Summary of the invention
In view of the deficiencies in the prior art, the object of the invention is to by furtheing investigate folk remedy, a kind of medicine promoting skin wound healing is provided.
The object of the present invention is achieved like this:
Promote a pharmaceutical composition for skin wound healing, be prepared from by adjuvant passable on active component and pharmaceutics, wherein said active component is the petroleum ether part extract of Rhizoma Astilbes Myrianthae raw material.It should be noted that, Rhizoma Astilbes Myrianthae raw material of the present invention is the rhizome of saxifragaceae plant astilbe myriantha Diels.
Preferably, promote that the pharmaceutical composition of skin wound healing is external preparation as mentioned above, described external preparation comprises ointment, ointment, gel.
Present invention also offers the preparation method of the pharmaceutical composition of above-mentioned promotion skin wound healing, the method comprises the steps: to take Rhizoma Astilbes Myrianthae raw material, pulverize, be placed in extraction element, decoct with water extraction, filter, obtain decocting liquid, be evaporated to the concentrated solution containing 0.3-1.0g crude drug, with petroleum ether extraction 1-4 time of 2-5 times of volume, obtain petroleum ether extraction liquid, decompression and solvent recovery is also condensed into thick paste, lyophilization, is ground into fine powder, obtain petroleum ether part extract, be then prepared into external preparation with passable adjuvant on pharmaceutics.
Found by animal experiment research, compare model control group, adopt Rhizoma Astilbes Myrianthae petroleum ether part extract ointment of the present invention significantly can shorten wound healing time, improve Wound healing rate, this imply that Rhizoma Astilbes Myrianthae petroleum ether part extract has and promote skin burn and scald wound Healing preferably.Based on above result of study, the present invention also provides a kind of pharmaceutical applications, that is: the petroleum ether part extract of Rhizoma Astilbes Myrianthae promotes the purposes in the medicine of skin wound healing in preparation; Or the petroleum ether part extract of Rhizoma Astilbes Myrianthae promotes the purposes in the medicine of skin burn wound healing in preparation.
Compared with prior art, pharmaceutical composition of the present invention is extracted by single medicinal material material and is prepared from, and taste is few and effect turns, obviously can promote wound tissue healing, more be better than other drug at shortening scab forming time with reducing in cicatrix area, there is short treating period, instant effect, the advantages such as good effect.
Detailed description of the invention
Be below preparation embodiment and the effect test example of Rhizoma Astilbes Myrianthae extract of the present invention and external preparation thereof, the present invention will be further explained, but this not means that protection scope of the present invention is subject to the restriction of following embodiment.
Embodiment 1: the preparation of Rhizoma Astilbes Myrianthae extract
Accurately take Rhizoma Astilbes Myrianthae 500g, pulverize with FW135 type Chinese medicine grinder, be placed in the extraction element with round-bottomed flask, the 5L that adds water decocts and extracts 2h, by four layers of filtered through gauze, obtains decocting liquid, repeat 2 times, collecting decoction, is evaporated to 1L, with 3L petroleum ether extraction 2 times, obtain petroleum ether extraction liquid and water raffinate, concentrating under reduced pressure becomes thick paste respectively, lyophilization, be ground into fine powder, obtain petroleum ether part extract 7.90g and the water extractive part 48.55g of Rhizoma Astilbes Myrianthae.
Embodiment 2: the preparation of Rhizoma Astilbes Myrianthae petroleum ether part ointment
Accurately take Rhizoma Astilbes Myrianthae petroleum ether part extract powder prepared by 5g embodiment 1, in the vaseline joining 25g melting and 20mL soybean oil, stir, precision takes 0.5g ethyl hydroxybenzoate as antiseptic, add, mixing, obtains Rhizoma Astilbes Myrianthae petroleum ether part ointment.
Embodiment 3: the preparation of Rhizoma Astilbes Myrianthae water position ointment
Accurately take Rhizoma Astilbes Myrianthae water extractive part powder prepared by 10g embodiment 1, in the vaseline joining 25g melting and 20mL soybean oil, stir, precision takes 0.5g ethyl hydroxybenzoate as antiseptic, adds, and mixing, obtains Rhizoma Astilbes Myrianthae water position ointment.
Embodiment 4: Rhizoma Astilbes Myrianthae ointment is tested the impact of mice wound tissue healing effect
Healthy kunming mice 48, female, weight 18 ~ 22g, is divided into Normal group, model control group, test A group and test B group at random by weight after adaptability raises 3d, often organizes 12 animals.Back depilation is carried out with 1O% sodium sulfide, the next day except Normal group its excess-three group mice all with 5% chloral hydrate intraperitoneal injection of anesthesia, 3cm × 4cm iron staff is placed in boiling water 10min, take out iron staff and be affixed on depilation mouse back immediately without hair position also lasting 10s, copy dark II degree of scalding model, wound area is about lcm × 2cm, drug treatment immediately after wound, 1 time/d.The Rhizoma Astilbes Myrianthae petroleum ether part ointment that test A group gives embodiment 2 preparation is treated, the Rhizoma Astilbes Myrianthae water position ointment that test B group gives embodiment 3 preparation is treated, Normal group and model control group all adopt blank ointment to treat, the preparation method of blank ointment is: by the vaseline of 25g melting and the mixing of 20mL soybean oil, precision takes 0.5g ethyl hydroxybenzoate and adds as antiseptic, mixing, simple Ointment agent of having leisure.
After administration 10d, measure Wound healing rate, method is as follows: traced on onionskin by wound surface, then as template, homogeneous hard paper is cut into pattern size, indirectly represents wound surface size with hard paper weight.Not Wound healing rate (%)=(scalding area-do not heal wound surface area in beginning)/start scalding area.Can be found out by the test statistics result of table 1, compare with model control group, test A group can significantly shorten wound healing time (
p< 0.01), raising Wound healing rate (
p< 0.01), and test B group effect and not obvious (
p> 0.05), this imply that Rhizoma Astilbes Myrianthae petroleum ether part extract has and promote skin burn and scald wound Healing preferably.
Table 1 respectively group mice wound tissue healing situation compares
| Group | Sample size | Wound healing time (d) | Wound healing rate (%) |
| Normal group | 12 | - | - |
| Model control group | 12 | 16.91±1.41 | 28.81±4.37 |
| Test B group | 12 | 15.70±1.35 | 30.28±5.90 |
| Test A group | 12 | 9.28±2.60 ★★▼▼ | 76.19±5.41 ★★▼▼ |
Compare with model control group,
★ p< 0.05;
★ ★ p< 0.01; Compare with test B group,
▼ p< 0.05;
▼ ▼ p< 0.01.
Claims (6)
1. promote a pharmaceutical composition for skin wound healing, be prepared from by adjuvant passable on active component and pharmaceutics, it is characterized in that: described active component is the petroleum ether part extract of Rhizoma Astilbes Myrianthae raw material.
2. promote the pharmaceutical composition of skin wound healing according to claim 1, it is characterized in that: described Rhizoma Astilbes Myrianthae raw material is the rhizome of saxifragaceae plant astilbe myriantha Diels.
3. according to claim 1 or 2, promote the pharmaceutical composition of skin wound healing, it is characterized in that: described pharmaceutical composition is external preparation, and described external preparation comprises ointment, ointment, gel.
4. one kind promotes the preparation method of the pharmaceutical composition of skin wound healing according to claim 3, it is characterized in that the method comprises the steps: to take Rhizoma Astilbes Myrianthae raw material, pulverize, be placed in extraction element, decoct with water extraction, filter, obtain decocting liquid, be evaporated to the concentrated solution containing 0.3-1.0g crude drug, with petroleum ether extraction 1-4 time of 2-5 times of volume, obtain petroleum ether extraction liquid, decompression and solvent recovery is also condensed into thick paste, lyophilization, be ground into fine powder, obtain petroleum ether part extract, then external preparation is prepared into passable adjuvant on pharmaceutics.
5. the petroleum ether part extract of Rhizoma Astilbes Myrianthae promotes the purposes in the medicine of skin wound healing in preparation.
6. the petroleum ether part extract of Rhizoma Astilbes Myrianthae promotes the purposes in the medicine of skin burn wound healing in preparation.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105194156A (en) * | 2015-10-28 | 2015-12-30 | 王振清 | Traditional Chinese medicine preparation for treating burns and scalds |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103520555A (en) * | 2013-10-27 | 2014-01-22 | 周文华 | Drug for treatment of migraine |
| CN104523780A (en) * | 2014-12-25 | 2015-04-22 | 李健 | Pharmaceutical composition for promoting healing of skin wound and preparation method of pharmaceutical composition |
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2015
- 2015-01-22 CN CN201510030993.1A patent/CN104622920A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103520555A (en) * | 2013-10-27 | 2014-01-22 | 周文华 | Drug for treatment of migraine |
| CN104523780A (en) * | 2014-12-25 | 2015-04-22 | 李健 | Pharmaceutical composition for promoting healing of skin wound and preparation method of pharmaceutical composition |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105194156A (en) * | 2015-10-28 | 2015-12-30 | 王振清 | Traditional Chinese medicine preparation for treating burns and scalds |
| CN105194156B (en) * | 2015-10-28 | 2020-07-17 | 王振清 | Chinese medicinal preparation for treating burn and scald |
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