CN109925367A - A kind of prevention and treatment hemorrhoid fit perfectly - Google Patents
A kind of prevention and treatment hemorrhoid fit perfectly Download PDFInfo
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Abstract
The invention discloses a kind of the submissive of prevention and treatment hemorrhoid.It successively includes internal layer, Chinese traditional medicine layer, outer layer and adhesion layer；The Chinese traditional medicine layer is by including that the Chinese medicine composition of following parts by weight of component is made: 20~40 parts of cherokee rose root, 10~25 parts of Radix Codonopsis, 15~25 parts of Radix Angelicae Sinensis, 10~20 parts of Herba Andrographitis, 10~25 parts of single side needle, 10~20 parts of leatherleaf mahonia, 10~15 parts of Caulis Spatholobi, 8~15 parts of philippine flemingia root；The internal layer is made of the dregs of a decoction of the Chinese medicine composition；Further can also it compound with Chinese medicines such as radix ampelopsis, dandelions.Hemorrhoid medicine of the invention is to be compounded for the treatment needs of hemorrhoid especially postpartum hemorrhoid, according to drug matching theory to the prophylactic treatment significant effect of hemorrhoid；And internal layer is made using the dregs of a decoction, remaining effective component can also be made full use of on the dregs of a decoction；In addition, product has no toxic side effect, highly-safe, pro-skin is non-stimulated, easy to use, is directly affixed on underpants, and application prospect is good.
Description
Technical field
The invention belongs to pharmaceutical technology fields.More particularly, to a kind of the submissive of prevention and treatment hemorrhoid.
Background technique
Hemorrhoid are a kind of common diseases positioned at anus area, and any age can all fall ill, but with age, morbidity
Rate gradually increases.In China, hemorrhoid are the most common anorectal diseases.Although hemorrhoid can be by reinforcing exercises, prevent constipation, reasonable
Allotment diet, the habit for forming timing defecation keep the precautionary measures such as perianal cleaning to prevent the generation of hemorrhoid, but this is simultaneously
Hemorrhoid cannot be fundamentally treated, therefore the quality of life of the patient with hemorrhoid is severely impacted.
Postpartum hemorrhoid are intracorporal uterus increase after women pregnancy, blood supply deficiency, with the development of fetus, uterus
Also it is constantly growing up, the uterus grown up influences whether the circulation of vein, causes blood backflow unsmooth, results in hemorrhoid.It produces
Hemorrhoid mainly have two aspect reasons afterwards: 1, the fetus being gradually increased due to the gestational period and its adjunct compressing cause anus part
Haemorrhoidal vein flows back obstacle, when childbirth, pregnant woman's long period with strength downwards firmly, more promoted venous congestion；Puerperal constipation pair
The stimulation of anus, can cause postpartum hemorrhoid to occur in postpartum, and haemorrhoids abjection aggravates hemorrhoid；2, due to postpartum, with fetus
It gives birth to, stomach, small intestine, large intestine are restored to normal position, and due to oppressing the removal of factor, enterocinesia is slack-off, pelvic cavity give a birth in addition after
Muscle and perianal muscle are excessively tight, and perineal wound pain and hemorrhoid pain, puerpera dare not firmly defecate, postpartum more clinostatisms,
Activity is few, lax abdominal wall, but feed few slag food, etc. constipation caused by reasons, aggravate hemorrhoid.
The treatment of hemorrhoid at present is mainly two aspect of drug therapy and operative treatment.1, best bet is still operation；
First is that routine operation, the less use now of this method, because doing, bleeding is more, and operating time is long；Second is that using
Instrument treatment, such as high frequency capacitance field technology (HCPT), mucous membrane of rectum procedure (PPH), each technology has its indication；
But although operation is fast, bleeding is few, can thoroughly solve the problems, such as relatively, operation can bring about certain postoperative pain, connect
Less by degree, general patient very serious can just select to perform the operation, and also some people, some situations are not suitable for performing the operation；And use hand
Art treats hemorrhoid and is easy recurrence.2, drug therapy, existing drug type is more, but curative effect is also irregular, barely satisfactory.
Summary of the invention
The technical problem to be solved by the present invention is to overcome the defect of existing hemorrhoid treating medicine and deficiencies, according to drug matching
Theory, for hemorrhoid especially postpartum hemorrhoid treatment need, give full play to Chinese medicine counteract each other, complementary effect, mention
For a kind of new compound Chinese medicinal preparation, it is mainly used for the treatment and prevention of hemorrhoid, it is significant in efficacy.
The object of the present invention is to provide a kind of the submissive of prevention and treatment hemorrhoid.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
A kind of prevention and treatment hemorrhoid fit perfectly, and successively include internal layer, Chinese traditional medicine layer, outer layer and adhesion layer；The Chinese traditional medicine layer is by including
The Chinese medicine composition of following parts by weight of component is made: 20~40 parts of cherokee rose root, 10~25 parts of Radix Codonopsis, 15~25 parts of Radix Angelicae Sinensis, punching
10~20 parts of lotus, 10~25 parts of single side needle, 10~20 parts of leatherleaf mahonia, 10~15 parts of Caulis Spatholobi, 8~15 parts of philippine flemingia root；In described
Layer is made of the dregs of a decoction of the Chinese medicine composition.
Preferably, the Chinese medicine composition includes the component of following parts by weight: 25~35 parts of cherokee rose root, Radix Codonopsis 15~20
Part, 20~23 parts of Radix Angelicae Sinensis, 15~18 parts of Herba Andrographitis, 15~20 parts of single side needle, 15~20 parts of leatherleaf mahonia, 13~15 parts of Caulis Spatholobi,
10~15 parts of philippine flemingia root.
It is highly preferred that the Chinese medicine composition includes the component of following parts by weight: 30 parts of cherokee rose root, 15 parts of Radix Codonopsis, Radix Angelicae Sinensis
20 parts, 15 parts of Herba Andrographitis, 20 parts of single side needle, 18 parts of leatherleaf mahonia, 13 parts of Caulis Spatholobi, 12 parts of philippine flemingia root.
It is further preferred that the Chinese medicine composition further includes the component of following parts by weight: 5~8 parts of radix ampelopsis, dandelion 5
~8 parts, 5~8 parts of the dried immature fruit of citron orange, 6~8 parts of pueraria lobata, 2~4 parts of Cortex Eucommiae, 6~8 parts of frutus cnidii, 5~8 parts of galla turcica, hairyflower actinidia root and leaf 2~4
Part, 2~4 parts of lantana, 2~4 parts of Radix Salviae Miltiorrhizae, 1~3 part of the achene of Siberian cocklebur, 1~3 part of pumpkin flower, 1~3 part of cortex cinnamomi, 1~3 part of Herba Cistanches,
1~3 part of Rhizoma Et Radix Notopterygii, 1~3 part of Chinese Drug Gualouzi, fan 1~3 part of fern, 1~3 part of radix polygonati officinalis, 1~3 part of cimicifugae foetidae.
Most preferably, the Chinese medicine composition is grouped as by the group of following parts by weight: 35 parts of cherokee rose root, 22 parts of Radix Codonopsis, when
Return 22 parts, 18 parts of Herba Andrographitis, 20 parts of single side needle, 18 parts of leatherleaf mahonia, 13 parts of Caulis Spatholobi, 10 parts of philippine flemingia root, 6 parts of radix ampelopsis, dandelion 7
It is part, 6 parts of the dried immature fruit of citron orange, 7 parts of pueraria lobata, 3 parts of Cortex Eucommiae, 7 parts of frutus cnidii, 6 parts of galla turcica, 3 parts of hairyflower actinidia root and leaf, 3 parts of lantana, 3 parts of Radix Salviae Miltiorrhizae, grey
2 parts of the ears or side handles of a utensil, 2 parts of pumpkin flower, 2 parts of cortex cinnamomi, 2 parts of Herba Cistanches, 2 parts of Rhizoma Et Radix Notopterygii, 2 parts of Chinese Drug Gualouzi, fan 2 parts of fern, 2 parts of radix polygonati officinalis, cimicifugae foetidae 2
Part.
In addition, prevention and treatment hemorrhoid submissive the preparation method is as follows:
S1. traditional Chinese medicinal components are utilized respectively and carry out effective component extraction using water extraction or alcohol extracting method, gained extracting solution closes
And it dries afterwards to water content 40% hereinafter, by intermittent low temperature sterilization；
S2. the product of step S1 is continued dry to water content 8% hereinafter, pulverizing to partial size no more than 80 μm, institute
Obtaining micropowders adds sesame oil, vaseline to be tuned into ointment；
S3. fiber is made in the remaining dregs of a decoction in step S1, with moso bamboo fiber, piemarker fiber for common raw material, utilizes weaving skill
Fiber cloth is made in art；
S4. ointment is spread evenly across fiber cloth, then covers one layer of fiber cloth；Then one side combines one layer of adhesion layer
And off-style paper layer；Finally sealed packaging.
Wherein it is preferred to the sterilising conditions of micropowders described in step S1 be 45~55 DEG C moist heat sterilization 2~3 hours,
It sterilizes again after having a rest 12~20 hours.
It is highly preferred that sterilising conditions be 50 DEG C moist heat sterilization 2~3 hours, interval 15~20 hours after sterilize again.
Preferably, disinfecting action repeats 3~5 times.
Preferably, the method for ultramicro grinding described in step S2 is: first drying to water content 10% hereinafter, to be ground into partial size small
In the pellet object of 30mm, continue dry to water content 8% hereinafter, pulverizing into the micropowders that partial size is no more than 100 μm again.
Preferably, the dregs of a decoction described in step S3 be made fiber cloth method it is as follows:
S31. it pre-processes: after dregs of a decoction drying to water content 25%~45%, carrying out Micro-wave pretreatment, microwave power
For 900~1500W, microwave irradiation time is 5~10min, for use；
S32. boiling: the pretreated dregs of a decoction are placed in boiling vessel, are 1:4~5 according to liquor ratio, mass concentration is added
It after 40%~60% ethanol solution, is rapidly heated to 120~140 DEG C, blowing after 100~120min of insulation reaction obtains thick
Slurry and black liquor；
S33. it washs: the obtained coarse particles of step S32 being placed in displacement washing device, with mass concentration 55%~70%
Ethanol solution carries out multistage displacement washing, and cleaning solution ratio is 1:7~8, and wash temperature is 40~60 DEG C；Then it is washed with water dry
Only, fibre semi-finished products are obtained after drying；
S34. the extraction of effective component: concentration is evaporated to the black liquor in S32, obtains water after recycling of condensed steam ethyl alcohol
Solution is concentrated, and obtaining has effective component solution；
S35. the effective component spray solution of S34 is obtained into the fiber with pharmacological property in the fiber surface of S33；
S36. it is combined with fiber obtained by step S35 and plant fiber material and is fabricated to fiber cloth.
The invention has the following advantages:
The present invention provides a kind of the submissive of prevention and treatment hemorrhoid, according to drug matching theory, for hemorrhoid especially postpartum hemorrhoid
The treatment of sore needs, give full play to Chinese medicine counteract each other, complementary effect, compound, to hemorrhoid especially postpartum hemorrhoid
The prophylactic treatment significant effect of sore.
And the present invention shows by test results such as anti-inflammation detumescence tests: the submissive product of the present invention has apparent anti-inflammatory work
With, have and significant inhibit granuloma effect.It therefore is the ideal medicament for preventing and treating hemorrhoid, and easy to use, directly
It is affixed on underpants, and has certain health-care effect, it also can the standing prevention autotherapy of family.
In addition, the preparation method of the product can make full use of the effective component of medicinal material, and thoroughly sterilized, it can be preferably
Guarantee the quality and safety of product.Submissive carrier material is made using the dregs of a decoction, is aided with plant, materials are natural, and pro-skin is stingless
Swash；Furthermore, it is possible to utilize the dregs of a decoction and wherein remaining a small amount of effective component to greatest extent；Importantly, in prepared
Herbal medicine fiber cloth inherently contains the Chinese medicine component and a large amount of effective component, can in use slowly not
Disconnected release effective component, significantly improves the effect of product.
Specific embodiment
Further illustrate the present invention below in conjunction with specific embodiment, but embodiment the present invention is not done it is any type of
It limits.Unless stated otherwise, the present invention uses reagent, method and apparatus is the art conventional reagents, method and apparatus.
Unless stated otherwise, following embodiment agents useful for same and material are commercially available.
Embodiment 1
1, a kind of prevention and treatment hemorrhoid is submissive, successively includes internal layer, Chinese traditional medicine layer, outer layer and adhesion layer；The internal layer is by described
The dregs of a decoction of Chinese medicine composition are made；The Chinese traditional medicine layer is by including that the Chinese medicine composition of following parts by weight of component is made: cherokee rose root 30
Part, 15 parts of Radix Codonopsis, 20 parts of Radix Angelicae Sinensis, 15 parts of Herba Andrographitis, 20 parts of single side needle, 18 parts of leatherleaf mahonia, 13 parts of Caulis Spatholobi, 12 parts of philippine flemingia root.
2, specifically, the prevention and treatment hemorrhoid submissive the preparation method is as follows:
S1. traditional Chinese medicinal components are utilized respectively and carry out effective component extraction using water extraction or alcohol extracting method, gained extracting solution closes
And it dries afterwards to water content 40% hereinafter, by intermittent low temperature sterilization；Sterilising conditions be 50 DEG C moist heat sterilization 2~3 hours,
It sterilizes again after having a rest 15~20 hours；Disinfecting action repeats 3~5 times；
S2. the product of step S1 is dried to water content 10% hereinafter, the pellet object for being ground into partial size less than 30mm, continues
Drying is to water content 8% hereinafter, pulverizing into the micropowders that partial size is no more than 100 μm again；Gained micropowders add sesame oil,
Vaseline is tuned into ointment；
S3. fiber is made in the remaining dregs of a decoction in step S1, with moso bamboo fiber, piemarker fiber for common raw material, utilizes weaving skill
Fiber cloth is made in art；
S4. ointment is spread evenly across fiber cloth, then covers one layer of fiber cloth；Then one side combines one layer of adhesion layer
And off-style paper layer；Finally sealed packaging.
Wherein, the dregs of a decoction described in step S3 be made fiber method it is as follows:
S31. it pre-processes: after dregs of a decoction drying to water content 25%~45%, carrying out Micro-wave pretreatment, microwave power
For 900~1500W, microwave irradiation time is 5~10min, for use；
S32. boiling: the pretreated dregs of a decoction are placed in boiling vessel, are 1:4~5 according to liquor ratio, mass concentration is added
It after 40%~60% ethanol solution, is rapidly heated to 120~140 DEG C, blowing after 100~120min of insulation reaction obtains thick
Slurry and black liquor；
S33. it washs: the obtained coarse particles of step S32 being placed in displacement washing device, with mass concentration 55%~70%
Ethanol solution carries out multistage displacement washing, and cleaning solution ratio is 1:7~8, and wash temperature is 40~60 DEG C；Then it is washed with water dry
Only, fibre semi-finished products are obtained after drying；
S34. the extraction of effective component: concentration is evaporated to the black liquor in S32, obtains water after recycling of condensed steam ethyl alcohol
Solution is concentrated, and obtaining has effective component solution；
S35. the effective component spray solution of S34 is obtained into the fiber with pharmacological property in the fiber surface of S33.
Embodiment 2
A kind of prevention and treatment hemorrhoid fit perfectly, and successively include internal layer, Chinese traditional medicine layer, outer layer and adhesion layer；The internal layer is by described
The dregs of a decoction of drug composition are made；The Chinese traditional medicine layer is by including that the Chinese medicine composition of following parts by weight of component is made: 35 parts of cherokee rose root,
20 parts of Radix Codonopsis, 23 parts of Radix Angelicae Sinensis, 18 parts of Herba Andrographitis, 20 parts of single side needle, 20 parts of leatherleaf mahonia, 15 parts of Caulis Spatholobi, 15 parts of philippine flemingia root.
The preparation method is the same as that of Example 1 for the prevention and treatment hemorrhoid submissive.
Embodiment 3
A kind of prevention and treatment hemorrhoid fit perfectly, and successively include internal layer, Chinese traditional medicine layer, outer layer and adhesion layer；The internal layer is by described
The dregs of a decoction of drug composition are made；The Chinese traditional medicine layer is by including that the Chinese medicine composition of following parts by weight of component is made: 25 parts of cherokee rose root,
15 parts of Radix Codonopsis, 20 parts of Radix Angelicae Sinensis, 15 parts of Herba Andrographitis, 15 parts of single side needle, 15 parts of leatherleaf mahonia, 13 parts of Caulis Spatholobi, 10 parts of philippine flemingia root.
The preparation method is the same as that of Example 1 for the prevention and treatment hemorrhoid submissive.
Embodiment 4
A kind of prevention and treatment hemorrhoid fit perfectly, and successively include internal layer, Chinese traditional medicine layer, outer layer and adhesion layer；The internal layer is by described
The dregs of a decoction of drug composition are made；The Chinese traditional medicine layer is by including that the Chinese medicine composition of following parts by weight of component is made: 40 parts of cherokee rose root,
25 parts of Radix Codonopsis, 25 parts of Radix Angelicae Sinensis, 20 parts of Herba Andrographitis, 25 parts of single side needle, 20 parts of leatherleaf mahonia, 15 parts of Caulis Spatholobi, 15 parts of philippine flemingia root.
The preparation method is the same as that of Example 1 for the prevention and treatment hemorrhoid submissive.
Embodiment 5
A kind of prevention and treatment hemorrhoid fit perfectly, and successively include internal layer, Chinese traditional medicine layer, outer layer and adhesion layer；The internal layer is by described
The dregs of a decoction of drug composition are made；The Chinese traditional medicine layer is by including that the Chinese medicine composition of following parts by weight of component is made: 20 parts of cherokee rose root,
10 parts of Radix Codonopsis, 15 parts of Radix Angelicae Sinensis, 10 parts of Herba Andrographitis, 10 parts of single side needle, 10 parts of leatherleaf mahonia, 10 parts of Caulis Spatholobi, 8 parts of philippine flemingia root.
The preparation method is the same as that of Example 1 for the prevention and treatment hemorrhoid submissive.
Embodiment 6
A kind of prevention and treatment hemorrhoid fit perfectly, and successively include internal layer, Chinese traditional medicine layer, outer layer and adhesion layer；The internal layer is by described
The dregs of a decoction of drug composition are made；The Chinese traditional medicine layer is by including that the Chinese medicine composition of following parts by weight of component is made: 35 parts of cherokee rose root,
22 parts of Radix Codonopsis, 22 parts of Radix Angelicae Sinensis, 18 parts of Herba Andrographitis, 20 parts of single side needle, 18 parts of leatherleaf mahonia, 13 parts of Caulis Spatholobi, 10 parts of philippine flemingia root, radix ampelopsis
6 parts, 7 parts of dandelion, 6 parts of the dried immature fruit of citron orange, 7 parts of pueraria lobata, 3 parts of Cortex Eucommiae, 7 parts of frutus cnidii, 6 parts of galla turcica, 3 parts of hairyflower actinidia root and leaf, lantana 3
Part, 3 parts of Radix Salviae Miltiorrhizae, 2 parts of the achene of Siberian cocklebur, 2 parts of pumpkin flower, 2 parts of cortex cinnamomi, 2 parts of Herba Cistanches, 2 parts of Rhizoma Et Radix Notopterygii, 2 parts of Chinese Drug Gualouzi, 2 parts of fern of fan, jade
2 parts of bamboo, 2 parts of cimicifugae foetidae.
The preparation method is the same as that of Example 1 for the prevention and treatment hemorrhoid submissive.
Embodiment 7
A kind of prevention and treatment hemorrhoid fit perfectly, and successively include internal layer, Chinese traditional medicine layer, outer layer and adhesion layer；The internal layer is by described
The dregs of a decoction of drug composition are made；The Chinese traditional medicine layer is by including that the Chinese medicine composition of following parts by weight of component is made: 35 parts of cherokee rose root,
22 parts of Radix Codonopsis, 22 parts of Radix Angelicae Sinensis, 18 parts of Herba Andrographitis, 20 parts of single side needle, 18 parts of leatherleaf mahonia, 13 parts of Caulis Spatholobi, 10 parts of philippine flemingia root, radix ampelopsis
8 parts, 8 parts of dandelion, 8 parts of the dried immature fruit of citron orange, 8 parts of pueraria lobata, 4 parts of Cortex Eucommiae, 8 parts of frutus cnidii, 8 parts of galla turcica, 4 parts of hairyflower actinidia root and leaf, lantana 4
Part, 4 parts of Radix Salviae Miltiorrhizae, 3 parts of the achene of Siberian cocklebur, 3 parts of pumpkin flower, 3 parts of cortex cinnamomi, 3 parts of Herba Cistanches, 3 parts of Rhizoma Et Radix Notopterygii, 3 parts of Chinese Drug Gualouzi, 3 parts of fern of fan, jade
3 parts of bamboo, 3 parts of cimicifugae foetidae.
The preparation method is the same as that of Example 1 for the prevention and treatment hemorrhoid submissive.
Embodiment 8
A kind of prevention and treatment hemorrhoid fit perfectly, and successively include internal layer, Chinese traditional medicine layer, outer layer and adhesion layer；The internal layer is by described
The dregs of a decoction of drug composition are made；The Chinese traditional medicine layer is by including that the Chinese medicine composition of following parts by weight of component is made: 35 parts of cherokee rose root,
22 parts of Radix Codonopsis, 22 parts of Radix Angelicae Sinensis, 18 parts of Herba Andrographitis, 20 parts of single side needle, 18 parts of leatherleaf mahonia, 13 parts of Caulis Spatholobi, 10 parts of philippine flemingia root, radix ampelopsis
5 parts, 5 parts of dandelion, 5 parts of the dried immature fruit of citron orange, 6 parts of pueraria lobata, 2 parts of Cortex Eucommiae, 6 parts of frutus cnidii, 5 parts of galla turcica, 2 parts of hairyflower actinidia root and leaf, lantana 2
Part, 2 parts of Radix Salviae Miltiorrhizae, 1 part of the achene of Siberian cocklebur, 1 part of pumpkin flower, 1 part of cortex cinnamomi, 1 part of Herba Cistanches, 1 part of Rhizoma Et Radix Notopterygii, 1 part of Chinese Drug Gualouzi, 1 part of fern of fan, jade
1 part of bamboo, 1 part of cimicifugae foetidae.
The preparation method is the same as that of Example 1 for the prevention and treatment hemorrhoid submissive.
The test of 9 product safety of embodiment
By taking the product of embodiment 1 and 6 as an example, with the drug administration for the product that fits perfectly, toxicity of the observation product external application to skin
And irritative response.
1, dermal toxicity test
Healthy adult rabbit is taken, if intact skin and damaged skin administration group, and respectively set blank control group.Test medicine connects
Rabbit is touched completely and after damaged skin, measurement breathing, heart rate and four limbs activity etc..
As a result with administration before and comparison among groups, statistically there was no significant difference, also there are no systemic toxicity.
2, skin irritation test
(1) rabbit skin irritation test is used, intact skin group and damage skin group are divided, respectively in the 1d of administration, continuous
After 7d, whether there is or not the stimulate the reactions such as erythema, oedema for observation skin.It is tested, is administered once daily using mouse skin allergy, continuous one
A month, whether there is or not the allergic reactions such as erythema, oedema for observation skin.
(2) the results show that the intact skin and damaged skin of rabbit, remove after being intended for single use or be used for multiple times for 24 hours, point
Not in 1,24,48,72h observation, it is showed no erythema and oedema, stimulate the reaction mean scores are < 0.5, nonirritant.Mouse skin
In allergic experiment, do not occur the cutaneous anaphylaxises such as the obvious erythema of skin, oedema and other systemic anaphylaxises.
Therefore, product of the present invention will not cause irritative response to rabbit intact skin and damage skin, to mouse skin
Without allergic reaction, there is good cutaneous safety.
10 product measure of merit of embodiment
By taking the product of embodiment 1 and 6 as an example, the submissive property and using effect of present invention prevention and treatment hemorrhoid is tested.
Administration grouping: experimental group 1: embodiment 1 fits perfectly drug；Experimental group 2: embodiment 6 fits perfectly drug；Control group: commercially available
Certain external application drug for haemorrhoid cream.
1, anti-inflammation detumescence is tested: inducing croton oil the inhibiting effect of mice auricle swelling
Weight 24~26g mouse is taken, half male and half female, is randomly divided into experimental group 1, experimental group 2 and control group by every group 10,
Each group is applied to the proinflammatory agent 0.05ml that 2% croton oil of content, 20% dehydrated alcohol, 5% distilled water, 70% ether mix small
Two sides causes inflammation before and after ear on the left of mouse.Cause it is scorching before and cause it is scorching after every 1 hour, cause inflammation to pick up the ears piece to each trial drug 0.05g/ only, office
It applies.Groups of animals takes off neck after applying proinflammatory agent 4 hours and puts to death, and cuts two ears, with the rubber stopper hole making drill of diameter 8mm, sweeps away
The garden auricle at the same position of two ears, weighing are calculated as swelling with two auricle weight difference of every mouse or so, are compared group difference, tied
Fruit is shown in Table 1, and drug office of the present invention, which applies administration, apparent anti-inflammatory effect, significantly inhibits swelling.
1 each group drug office of table applies the anti-inflammatory effect to mouse ear swelling
2, to the granulomatous inhibiting effect of rat chronic:
Take 175 ± 15g of weight rat (SD strain), male, every group 10, be randomly divided into experimental group 1, experimental group 2 with it is right
According to group, rat is under the shallow fiber crops of ether, routine disinfection, and sterile working cuts lower abdomen skin along median line, separates skin with vessel forceps
Undertissue, it is subcutaneous at the groin of left and right, filter paper 1 of each embedment measurement antibiotic activity, suture.Postoperative administration group part
Coating 0.1g/ only, three times a day, continuous one week, puts to death animal, carefulness removing granuloma is extracted with filter paper, together in oven
After 60 DEG C of dryings 24 hours to constant weight, assay balance weighing, gross weight subtracts filter paper slice weight, as granuloma weight, with mg/
100gBW is indicated, compares group difference.It the results are shown in Table 2, filter paper buries in drug local application of the present invention causes chronic granulo
It is swollen to have significant inhibiting effect.
2 each group drug office of table applies the inhibiting effect to rat (filter method) chronic granuloma
11 clinical application example of embodiment
1,210 postpartum hemorrhoid cases are pressed into random digits table, are randomly divided into experimental group 1, experimental group 2 and control group,
Every group 70.
The average age of experimental group 1 32.8 years old, the average age of experimental group 2 33.5 years old, the average age 33.2 of control group
Year.The state of an illness and three groups of diagnosis situations are shown in Table 1.Three groups of Sex, Age situations are statistically analyzed, no significant difference (P > 0.05),
It is comparable.
2, it is administered
Experimental group 1: embodiment 1 is submissive；Experimental group 2: embodiment 6 is submissive；Control group: certain commercially available external application drug for haemorrhoid cream.
Daily medication is primary.
3, curative effect
Curative effect is drafted according to standard is divided into recovery from illness, effective, effective, invalid level Four, and concrete outcome is shown in Table 3.
3 three groups of curative effect statistics of table
The results show that submissive drug of the invention has significant curative effect to hemorrhoid；The total effective rate of experimental group and control group
Compare with cure rate, there were significant differences (P < 0.05).
4, safety analysis
210 patients of this research do not have found that patient's blood routine, routine urinalysis, just conventional, blood biochemistry index includes after medication
Hepatic and renal function, heart figure have the change of obvious clinical meaning, show the generation that has no toxic side effect after medication；210 patients are invariably
Good reaction occurs.
The above embodiment is a preferred embodiment of the present invention, but embodiments of the present invention are not by above-described embodiment
Limitation, other any changes, modifications, substitutions, combinations, simplifications made without departing from the spirit and principles of the present invention,
It should be equivalent substitute mode, be included within the scope of the present invention.
Claims (10)
1. a kind of prevention and treatment hemorrhoid is submissive, which is characterized in that successively include internal layer, Chinese traditional medicine layer, outer layer and adhesion layer；The Chinese medicine
Layer is by including that the Chinese medicine composition of following parts by weight of component is made: 20~40 parts of cherokee rose root, 10~25 parts of Radix Codonopsis, Radix Angelicae Sinensis 15~25
Part, 10~20 parts of Herba Andrographitis, 10~25 parts of single side needle, 10~20 parts of leatherleaf mahonia, 10~15 parts of Caulis Spatholobi, 8~15 parts of philippine flemingia root；
The internal layer is made of the dregs of a decoction of the Chinese medicine composition.
2. preventing and treating the submissive of hemorrhoid according to claim 1, which is characterized in that the Chinese medicine composition includes following parts by weight
Component: 25~35 parts of cherokee rose root, 15~20 parts of Radix Codonopsis, 20~23 parts of Radix Angelicae Sinensis, 15~18 parts of Herba Andrographitis, single side needle 15~20
Part, 15~20 parts of leatherleaf mahonia, 13~15 parts of Caulis Spatholobi, 10~15 parts of philippine flemingia root.
3. preventing and treating the submissive of hemorrhoid according to claim 2, which is characterized in that the Chinese medicine composition includes following parts by weight
Component: 30 parts of cherokee rose root, 15 parts of Radix Codonopsis, 20 parts of Radix Angelicae Sinensis, 15 parts of Herba Andrographitis, 20 parts of single side needle, 18 parts of leatherleaf mahonia, Caulis Spatholobi 13
Part, 12 parts of philippine flemingia root.
4. preventing and treating the submissive of hemorrhoid according to claim 3, which is characterized in that the Chinese medicine composition further includes following weight
The component of part: 5~8 parts of radix ampelopsis, 5~8 parts of dandelion, 5~8 parts of the dried immature fruit of citron orange, 6~8 parts of pueraria lobata, 2~4 parts of Cortex Eucommiae, frutus cnidii 6~8
Part, 5~8 parts of galla turcica, 2~4 parts of hairyflower actinidia root and leaf, 2~4 parts of lantana, 2~4 parts of Radix Salviae Miltiorrhizae, 1~3 part of the achene of Siberian cocklebur, pumpkin flower 1~3
Part, 1~3 part of cortex cinnamomi, 1~3 part of Herba Cistanches, 1~3 part of Rhizoma Et Radix Notopterygii, 1~3 part of Chinese Drug Gualouzi, fan 1~3 part of fern, 1~3 part of radix polygonati officinalis, cimicifugae foetidae
1~3 part.
5. preventing and treating the submissive of hemorrhoid according to claim 4, which is characterized in that the Chinese medicine composition is by following parts by weight
Group is grouped as: 35 parts of cherokee rose root, 22 parts of Radix Codonopsis, 22 parts of Radix Angelicae Sinensis, 18 parts of Herba Andrographitis, 20 parts of single side needle, 18 parts of leatherleaf mahonia, Caulis Spatholobi
13 parts, 10 parts of philippine flemingia root, 6 parts of radix ampelopsis, 7 parts of dandelion, 6 parts of the dried immature fruit of citron orange, 7 parts of pueraria lobata, 3 parts of Cortex Eucommiae, 7 parts of frutus cnidii, galla turcica 6
Part, 3 parts of hairyflower actinidia root and leaf, 3 parts of lantana, 3 parts of Radix Salviae Miltiorrhizae, 2 parts of the achene of Siberian cocklebur, 2 parts of pumpkin flower, 2 parts of cortex cinnamomi, 2 parts of Herba Cistanches, 2 parts of Rhizoma Et Radix Notopterygii,
2 parts of Chinese Drug Gualouzi, fan 2 parts of fern, 2 parts of radix polygonati officinalis, 2 parts of cimicifugae foetidae.
6. any prevention and treatment hemorrhoid is submissive according to claim 1~5, which is characterized in that be prepared by the following method:
S1. traditional Chinese medicinal components are utilized respectively and carry out effective component extraction using water extraction or alcohol extracting method, after gained extracting solution merges
Drying is to water content 40% hereinafter, by intermittent low temperature sterilization；
S2. the product of step S1 is continued dry to water content 8% hereinafter, pulverizing to partial size no more than 80 μm, gained ultra micro
Fine powder adds sesame oil, vaseline to be tuned into ointment；
S3. fiber is made in the remaining dregs of a decoction in step S1, with moso bamboo fiber, piemarker fiber for common raw material, utilizes textile technology system
At fiber cloth；
S4. ointment is spread evenly across fiber cloth, then covers one layer of fiber cloth；Then one side combine one layer of adhesion layer and from
Type paper layer；Finally sealed packaging.
7. preventing and treating the submissive of hemorrhoid according to claim 6, which is characterized in that the method for ultramicro grinding described in step S2 is:
It first dries to water content 10% hereinafter, the pellet object for being ground into partial size less than 30mm, continues dry to water content 8% hereinafter, surpassing again
Crushing of Ultrafine is no more than 100 μm of micropowders at partial size.
8. preventing and treating the submissive of hemorrhoid according to claim 6, which is characterized in that the sterilising conditions of micropowders described in step S1
For 45~55 DEG C moist heat sterilization 2~3 hours, interval 12~20 hours after sterilize again.
9. preventing and treating the submissive of hemorrhoid according to claim 8, which is characterized in that sterilising conditions are that 50 DEG C of moist heat sterilizations 2~3 are small
When, interval sterilizes again after 15~20 hours.
10. preventing and treating the submissive of hemorrhoid according to claim 8, which is characterized in that disinfecting action repeats 3~5 times.
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| CN201711358300.7A CN109925367A (en) | 2017-12-17 | 2017-12-17 | A kind of prevention and treatment hemorrhoid fit perfectly |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111235915A (en) * | 2020-03-23 | 2020-06-05 | 德州学院 | Bamboo fiber fabric dyeing method based on mahonia broadleaf plant dye |
| CN113209171A (en) * | 2021-05-30 | 2021-08-06 | 张成甫 | Preparation method and device of medicament for treating hemorrhoids through navel-pasting wet-dressing therapy |
-
2017
- 2017-12-17 CN CN201711358300.7A patent/CN109925367A/en not_active Withdrawn
Non-Patent Citations (1)
| Title |
|---|
| 郝玉珩等: "《国家基本医疗保险处方手册》", 31 March 2004, 中国环境科学出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111235915A (en) * | 2020-03-23 | 2020-06-05 | 德州学院 | Bamboo fiber fabric dyeing method based on mahonia broadleaf plant dye |
| WO2021189707A1 (en) * | 2020-03-23 | 2021-09-30 | 德州学院 | Method for dyeing bamboo fiber fabric on basis of mahonia bealei (fort.) carr. plant dye |
| CN113209171A (en) * | 2021-05-30 | 2021-08-06 | 张成甫 | Preparation method and device of medicament for treating hemorrhoids through navel-pasting wet-dressing therapy |
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