CN109924553A - A kind of Chinese herbal medicine socks for preventing and treating tinea pedis - Google Patents
A kind of Chinese herbal medicine socks for preventing and treating tinea pedis Download PDFInfo
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- CN109924553A CN109924553A CN201711358297.9A CN201711358297A CN109924553A CN 109924553 A CN109924553 A CN 109924553A CN 201711358297 A CN201711358297 A CN 201711358297A CN 109924553 A CN109924553 A CN 109924553A
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Abstract
The invention discloses a kind of Chinese herbal medicine socks for preventing and treating tinea pedis, it is made of herbal composite mixing cotton fiber or bamboo charcoal fiber are blended, wherein herbal composite includes the component of following parts by weight: 23~28 parts of cherokee rose root, 20~29 parts of Radix Codonopsis, 24~30 parts of Radix Angelicae Sinensis, 14~19 parts of Herba Andrographitis, 19~30 parts of single side needle, 16~32 parts of leatherleaf mahonia, 19~24 parts of Caulis Spatholobi, 12~20 parts of philippine flemingia root；The Chinese herbal medicines such as corter pseudolaricis, Cortex Phellodendri can also further be compounded；The herbal composite of selection according to drug matching theory, for tinea pedis treatment need, give full play to Chinese medicine counteract each other, complementary effect；The present invention is processed into plant fiber by carrying out Chinese medicine dreg, it is blended at cloth with cotton fiber or bamboo charcoal fiber, and by middle the effective elements of the medicine in conjunction with cloth, it is disappeared using Chinese herbal medicine socks clinical symptoms of the present invention rapid, analgesic, antipruritic and prevent foot odour rapidly, it to the prophylactic treatment significant effect of tinea pedis, is used conveniently and safely, application prospect is good.
Description
Technical field
The present invention relates to Traditional Chinese medicine health-care article fields, more particularly, to a kind of Chinese herbal medicine socks for preventing and treating tinea pedis.
Background technique
Tinea pedis (popular name " athlete's foot ", tinea pedis), is the foot dermatosis as caused by pathogenic fungus, has infectiousness.Foot
Tinea is popular in the whole world, more universal in subtropical and tropical zones.In China, the disease incidence of tinea pedis is also quite high.People
Vola and toe between without sebaceous glands, thus lack inhibit skin filamentous fungi fatty acid, physiological defense function is poor, and this
The sweat gland of skin at a little positions is but very abundant, perspires relatively more, and air circulation is poor in addition, part damp warm, is conducive to filiform
The growth of fungi.In addition, bottom of the foot keratoderma is thicker, the keratin in cuticula is the abundant nutrition substance of fungi,
Be conducive to the growth of fungi.Women during gestation, due to endocrine variation, causes skin to be resisted under the ability of fungal infection
Drop, is susceptible to suffer from tinea pedis.For overweight people because moist between toe, sweat dipping is susceptible to suffer from tinea pedis.Pedal skin is destroyed the defence of skin by wound
Function, and induce one of the factor of tinea pedis.Diabetic leads to metabolism disorder due to lacking insulin, and skin is containing sugar
Amount, which increases, causes resistance to decline, and is also susceptible to suffer from tinea pedis.Corticosteroid hormone and immunosuppressor is used for a long time in abuse of antibiotics
Deng, make skin normal flora lack of proper care, also will increase the neurological susceptibility of tinea pedis.
It is wet soft that the clinical manifestation of tinea pedis plays blister, decortication or skin whitening between toe, also may occur in which that rotten to the corn or skin increases
Thick, coarse, cracking, and vola pedis and edge, itching can be spread to；Can be with local suppuration, red and swollen, pain, inguinal lymph nodes is swollen
Greatly, in addition formed the secondary infections such as shank erysipelas and cellulitis；Great inconvenient, awkward and pain is brought to life.
It is often treated at present with antifungal drug, common product has Da Kening, Lamisil, Pevisone, PIKANGWANG and foot
Light dissipates etc., still, is easy to make the tinea pedis fungi that can be treated very well originally to have drug resistance using the Western medicine containing steroids, causes
The circumstances that recurs every year；And long-term Western medicine of the abuse containing steroids is also easier to that myasthenia, muscular atrophy, sclerotin is caused to be dredged
Pine can cause pathologic fracture or avascular necrosis of femoral head etc..
In addition, also have for tinea pedis pathogenesis, using antipruritic and other effects the Chinese medicine of clearing heat and expelling damp, removing pattogenic heat from the blood and toxic material from the body, desinsection
Formula is treated, but curative effect is also irregular, high recurrence rate.
However, general drug therapy, medication, dosage form are more single, and human sense of comfort is poor when due to using is difficult to
Adhere to lasting medication.
Summary of the invention
The technical problem to be solved by the present invention is to for the existing pharmaceutical dosage form for treating tinea pedis is single, comfort is poor, is difficult to
The technical deficiency for adhering to medication provides a kind of Chinese herbal medicine socks for preventing and treating tinea pedis.
The purpose of the present invention is achieved by the following technical programs:
A kind of Chinese herbal medicine socks for preventing and treating tinea pedis are provided, the socks use herbal composite mixing cotton fiber or bamboo charcoal
Fiber blend is made, and the herbal composite includes the component of following parts by weight: 23~28 parts of cherokee rose root, Radix Codonopsis 20~29
Part, 24~30 parts of Radix Angelicae Sinensis, 14~19 parts of Herba Andrographitis, 19~30 parts of single side needle, 16~32 parts of leatherleaf mahonia, 19~24 parts of Caulis Spatholobi,
12~20 parts of philippine flemingia root.
Preferably, state the component that Chinese medicine composition includes following parts by weight: 23~25 parts of cherokee rose root, 23~25 parts of Radix Codonopsis,
It is 27~29 parts of Radix Angelicae Sinensis, 17~19 parts of Herba Andrographitis, 23~26 parts of single side needle, 22~25 parts of leatherleaf mahonia, 19~22 parts of Caulis Spatholobi, very heavy
Pull out 18~20 parts.
It is highly preferred that the Chinese medicine composition includes the component of following parts by weight: 25 parts of cherokee rose root, 24 parts of Radix Codonopsis, Radix Angelicae Sinensis
27 parts, 18 parts of Herba Andrographitis, 25 parts of single side needle, 24 parts of leatherleaf mahonia, 20 parts of Caulis Spatholobi, 19 parts of philippine flemingia root.
Further, the Chinese medicine composition further includes the component of following parts by weight: 5~10 parts of corter pseudolaricis, Cortex Phellodendri 10~
20 parts, 8~12 parts of lantana, 8~12 parts of tea seed cake, 8~12 parts of rhizoma cyperi, 10~15 parts of Prunella vulgaris, 9~13 parts of Rhizoma Chuanxiong, corn stigma 6
~9 parts, 5~8 parts of the seed of cowherb, 5~8 parts of Schisandra chinensis, 4~7 parts of centella, 3~6 parts of leached tea oil slag, 3~7 parts of frutus cnidii, radix paeoniae rubra
3~6 parts, 2~5 parts of tripterygium wilfordii, 2~5 parts of Radix Astragali, 3~6 parts of Morinda officinalis, 3~5 parts of schizonepeta, 2~4 parts of rhizoma anemarrhenae, 1~3 part of Armstrong,
1~3 part of wartwort, 2~5 parts of fructus piperis longi, 1~3 part of Flos Magnoliae Liliflorae, 2~4 parts of Asian puccoon, 2~4 parts of Myriogyne minuta, 2~4 parts of fructus viticis, thorn five
Add 2~5 parts, 2~4 parts of honeysuckle, 1~3 part of gentianae macrophyllae, 1~3 part of curcuma zedoary.
Preferably, the Chinese medicine composition is grouped as by the group of following parts by weight: 25 parts of cherokee rose root, 24 parts of Radix Codonopsis, Radix Angelicae Sinensis
27 parts, 18 parts of Herba Andrographitis, 25 parts of single side needle, 24 parts of leatherleaf mahonia, 20 parts of Caulis Spatholobi, 19 parts of philippine flemingia root, 6 parts of corter pseudolaricis, Cortex Phellodendri 10
Part, 11 parts of lantana, 10 parts of tea seed cake, 10 parts of rhizoma cyperi, 13 parts of Prunella vulgaris, 11 parts of Rhizoma Chuanxiong, 7 parts of corn stigma, 6 parts of the seed of cowherb, five
6 parts of taste, 5 parts of centella, 5 parts of leached tea oil slag, 7 parts of frutus cnidii, 4 parts of radix paeoniae rubra, 3 parts of tripterygium wilfordii, 5 parts of Radix Astragali, 5 parts of Morinda officinalis, chaste tree
4 parts of mustard, 3 parts of rhizoma anemarrhenae, 2 parts of Armstrong, 2 parts of wartwort, 4 parts of fructus piperis longi, 2 parts of Flos Magnoliae Liliflorae, 3 parts of Asian puccoon, 3 parts of Myriogyne minuta, 3 parts of fructus viticis,
4 parts of wilsonii, 3 parts of honeysuckle, 2 parts of gentianae macrophyllae, 2 parts of curcuma zedoary.
Further, the socks preparation method the following steps are included:
S1. it impregnates: cherokee rose root, Radix Codonopsis, Radix Angelicae Sinensis, Herba Andrographitis, single side needle, leatherleaf mahonia, Caulis Spatholobi, philippine flemingia root is utilized respectively
Water extraction or alcohol extracting method carry out effective component extraction, and gained extracting solution merges, and the dregs of a decoction merge stand-by；
S2. it sterilizes: by step S1 Chinese medicine slag and other traditional Chinese medicinal components, by then intermittent low temperature goes out after being separately dried
Bacterium；
S3. it pre-processes: after product drying to water content 25%~45% in step S2, carrying out Micro-wave pretreatment,
For use；
S4. boiling: the pretreated dregs of a decoction are placed in boiling vessel, after ethanol solution is added, are rapidly heated, insulation reaction
Blowing afterwards obtains coarse particles and cooking liquor；
S5. it washs: the obtained coarse particles of step S4 being placed in displacement washing device, with the second of mass concentration 55%~70%
Alcoholic solution carries out multistage displacement washing, and cleaning solution ratio is 1:7~8, and wash temperature is 40~60 DEG C；Then it is washed with water completely,
Fibre semi-finished products are obtained after drying；
S6. the extraction of effective component: being evaporated concentration to the cooking liquor in step S4, after recycling of condensed steam ethyl alcohol
It is concentrated to aqueous solution, obtaining has effective component solution, merges with extracting solution in step S1, obtains effective component mixed liquor；
S7. the fibre semi-finished products of step S5 are soaked in the effective component mixed liquor of step S4, dry, obtaining has medicine
The fiber of property；
S8. blend fibre line is made into using fiber obtained by step S7 and cotton fiber or bamboo charcoal fiber；
S9. by after blend fibre line is made into embryo cloth in step S8, socks are made.
Preferably, the sterilising conditions of intermittent low temperature sterilization described in step S2 be 45~55 DEG C moist heat sterilization 2~3 hours,
It intermittently sterilizes again after 12~20 hours, repeats sterilizing 3~5 times.
Preferably, it is 900~1500W, microwave radiation that the condition of Micro-wave pretreatment described in step S3, which is microwave power,
Time is 5~10min.
Preferably, the solid-liquid ratio of the dregs of a decoction described in step S4 and ethanol solution is 1:4~5；The quality of the ethanol solution
Concentration is 40%~60%；The warming temperature is 120~140 DEG C；The insulation reaction is 100~120min often.
Preferably, the mass concentration of ethanol solution described in step S5 is 40%~60%；The coarse particles and cleaning solution
Solid-liquid ratio is 1:7~8；The wash temperature is 40~60 DEG C.
The invention has the following advantages:
The present invention provides a kind of Chinese herbal medicine socks for preventing and treating tinea pedis, the socks are fine using herbal composite mixing cotton
Dimension or bamboo charcoal fiber is blended is made, selected drug is pure Chinese herbal medicine, and according to drug matching theory, the treatment for tinea pedis needs,
Give full play to Chinese medicine counteract each other, complementary effect, compound, collaboration compatibility it is reasonable, short treating period, expense are low, tinea pedis
Symptom disappears rapidly, to the prophylactic treatment significant effect of tinea pedis, no dermal toxicity and irritation.
The present invention is processed into plant fiber by carrying out Chinese medicine dreg, blended at cloth with cotton fiber or bamboo charcoal fiber
Material, and by middle the effective elements of the medicine in conjunction with cloth, using Chinese herbal medicine socks of the invention, have to a variety of foot fungis aobvious
The bacteriostatic activity of work, can treating both manifestation and root cause of disease, long-time service can make tinea pedis uneasy to recur.
Chinese herbal medicine socks of the present invention can directly connect with patient's skin area for a long time in the therapeutic process of tinea pedis
Touching compares other treatment mode, increases drug treating time significantly, significant in efficacy.
The herbal powder manufacturing process that Chinese herbal medicine socks of the present invention use is simple to operation, at low cost, peace easy to use
Entirely, there is analgesic, antipruritic and therapeutic effect rapidly, effect is prominent, and application prospect is good.
Chinese herbal medicine socks comfort of the invention is excellent, right almost without difference in comfort level compared with regular socks
Minimal invasive treatment's influence is very small, easily adheres to using market prospects are good.
Specific embodiment
Further illustrate the present invention below in conjunction with specific embodiment, but embodiment the present invention is not done it is any type of
It limits.Unless stated otherwise, the present invention uses reagent, method and apparatus is the art conventional reagents, method and apparatus.
Unless stated otherwise, following embodiment agents useful for same and material are commercially available.
Embodiment 1
A kind of Chinese herbal medicine socks for preventing and treating tinea pedis, the socks use herbal composite mixing cotton fiber or bamboo charcoal fiber
It is blended to be made, wherein herbal composite includes the component of following parts by weight: 28 parts of cherokee rose root, 24 parts of Radix Codonopsis, 26 parts of Radix Angelicae Sinensis,
17 parts of Herba Andrographitis, 30 parts of single side needle, 32 parts of leatherleaf mahonia, 22 parts of Caulis Spatholobi, 20 parts of philippine flemingia root.
Specifically, the Chinese herbal medicine socks preparation method the following steps are included:
S1. it impregnates: cherokee rose root, Radix Codonopsis, Radix Angelicae Sinensis, Herba Andrographitis, single side needle, leatherleaf mahonia, Caulis Spatholobi, philippine flemingia root is utilized respectively
Water extraction or alcohol extracting method carry out effective component extraction, and gained extracting solution merges, and the dregs of a decoction merge stand-by；
S2. it sterilizes: by step S1 Chinese medicine slag and other traditional Chinese medicinal components, by then intermittent low temperature goes out after being separately dried
Bacterium；
S3. it pre-processes: after product drying to water content 25%~45% in step S2, carrying out Micro-wave pretreatment,
For use；
S4. boiling: the pretreated dregs of a decoction are placed in boiling vessel, after ethanol solution is added, are rapidly heated, insulation reaction
Blowing afterwards obtains coarse particles and cooking liquor；
S5. it washs: the obtained coarse particles of step S4 being placed in displacement washing device, with the second of mass concentration 55%~70%
Alcoholic solution carries out multistage displacement washing, and cleaning solution ratio is 1:7~8, and wash temperature is 40~60 DEG C；Then it is washed with water completely,
Fibre semi-finished products are obtained after drying；
S6. the extraction of effective component: being evaporated concentration to the cooking liquor in step S4, after recycling of condensed steam ethyl alcohol
It is concentrated to aqueous solution, obtaining has effective component solution, merges with extracting solution in step S1, obtains effective component mixed liquor；
S7. the fibre semi-finished products of step S5 are soaked in the effective component mixed liquor of step S4, dry, obtaining has medicine
The fiber of property；
S8. blend fibre line is made into using fiber obtained by step S7 and cotton fiber or bamboo charcoal fiber；
S9. by after blend fibre line is made into embryo cloth in step S8, socks are made.
Embodiment 2
A kind of Chinese herbal medicine socks for preventing and treating tinea pedis, the socks use herbal composite mixing cotton fiber or bamboo charcoal fiber
It is blended to be made, wherein herbal composite includes the component of following parts by weight: 23 parts of cherokee rose root, 29 parts of Radix Codonopsis, 30 parts of Radix Angelicae Sinensis,
14 parts of Herba Andrographitis, 25 parts of single side needle, 22 parts of leatherleaf mahonia, 24 parts of Caulis Spatholobi, 19 parts of philippine flemingia root.
Specifically, the Chinese herbal medicine socks preparation method the following steps are included:
S1. it impregnates: cherokee rose root, Radix Codonopsis, Radix Angelicae Sinensis, Herba Andrographitis, single side needle, leatherleaf mahonia, Caulis Spatholobi, philippine flemingia root is utilized respectively
Water extraction or alcohol extracting method carry out effective component extraction, and gained extracting solution merges, and the dregs of a decoction merge stand-by；
S2. it sterilizes: by step S1 Chinese medicine slag and other traditional Chinese medicinal components, by then intermittent low temperature goes out after being separately dried
Bacterium；
S3. it pre-processes: after product drying to water content 25%~45% in step S2, carrying out Micro-wave pretreatment,
For use；
S4. boiling: the pretreated dregs of a decoction are placed in boiling vessel, after ethanol solution is added, are rapidly heated, insulation reaction
Blowing afterwards obtains coarse particles and cooking liquor；
S5. it washs: the obtained coarse particles of step S4 being placed in displacement washing device, with the second of mass concentration 55%~70%
Alcoholic solution carries out multistage displacement washing, and cleaning solution ratio is 1:7~8, and wash temperature is 40~60 DEG C；Then it is washed with water completely,
Fibre semi-finished products are obtained after drying；
S6. the extraction of effective component: being evaporated concentration to the cooking liquor in step S4, after recycling of condensed steam ethyl alcohol
It is concentrated to aqueous solution, obtaining has effective component solution, merges with extracting solution in step S1, obtains effective component mixed liquor；
S7. the fibre semi-finished products of step S5 are soaked in the effective component mixed liquor of step S4, dry, obtaining has medicine
The fiber of property；
S8. blend fibre line is made into using fiber obtained by step S7 and cotton fiber or bamboo charcoal fiber；
S9. by after blend fibre line is made into embryo cloth in step S8, socks are made.
Embodiment 3
A kind of Chinese herbal medicine socks for preventing and treating tinea pedis, the socks use herbal composite mixing cotton fiber or bamboo charcoal fiber
It is blended to be made, wherein herbal composite includes the component of following parts by weight: 25 parts of cherokee rose root, 25 parts of Radix Codonopsis, 29 parts of Radix Angelicae Sinensis,
18 parts of Herba Andrographitis, 26 parts of single side needle, 24 parts of leatherleaf mahonia, 20 parts of Caulis Spatholobi, 19 parts of philippine flemingia root.
Specifically, the Chinese herbal medicine socks preparation method the following steps are included:
S1. it impregnates: cherokee rose root, Radix Codonopsis, Radix Angelicae Sinensis, Herba Andrographitis, single side needle, leatherleaf mahonia, Caulis Spatholobi, philippine flemingia root is utilized respectively
Water extraction or alcohol extracting method carry out effective component extraction, and gained extracting solution merges, and the dregs of a decoction merge stand-by；
S2. it sterilizes: by step S1 Chinese medicine slag and other traditional Chinese medicinal components, by then intermittent low temperature goes out after being separately dried
Bacterium；
S3. it pre-processes: after product drying to water content 25%~45% in step S2, carrying out Micro-wave pretreatment,
For use；
S4. boiling: the pretreated dregs of a decoction are placed in boiling vessel, after ethanol solution is added, are rapidly heated, insulation reaction
Blowing afterwards obtains coarse particles and cooking liquor；
S5. it washs: the obtained coarse particles of step S4 being placed in displacement washing device, with the second of mass concentration 55%~70%
Alcoholic solution carries out multistage displacement washing, and cleaning solution ratio is 1:7~8, and wash temperature is 40~60 DEG C；Then it is washed with water completely,
Fibre semi-finished products are obtained after drying；
S6. the extraction of effective component: being evaporated concentration to the cooking liquor in step S4, after recycling of condensed steam ethyl alcohol
It is concentrated to aqueous solution, obtaining has effective component solution, merges with extracting solution in step S1, obtains effective component mixed liquor；
S7. the fibre semi-finished products of step S5 are soaked in the effective component mixed liquor of step S4, dry, obtaining has medicine
The fiber of property；
S8. blend fibre line is made into using fiber obtained by step S7 and cotton fiber or bamboo charcoal fiber；
S9. by after blend fibre line is made into embryo cloth in step S8, socks are made.
Embodiment 4
A kind of Chinese herbal medicine socks for preventing and treating tinea pedis, the socks use herbal composite mixing cotton fiber or bamboo charcoal fiber
It is blended to be made, wherein herbal composite includes the component of following parts by weight: 24 parts of cherokee rose root, 20 parts of Radix Codonopsis, 24 parts of Radix Angelicae Sinensis,
18 parts of Herba Andrographitis, 19 parts of single side needle, 25 parts of leatherleaf mahonia, 18 parts of Caulis Spatholobi, 18 parts of philippine flemingia root.
The preparation method is the same as that of Example 1 for the Chinese herbal medicine socks.
Embodiment 5
A kind of Chinese herbal medicine socks for preventing and treating tinea pedis, the socks use herbal composite mixing cotton fiber or bamboo charcoal fiber
It is blended to be made, wherein herbal composite includes the component of following parts by weight: 26 parts of cherokee rose root, 23 parts of Radix Codonopsis, 28 parts of Radix Angelicae Sinensis,
19 parts of Herba Andrographitis, 23 parts of single side needle, 16 parts of leatherleaf mahonia, 19 parts of Caulis Spatholobi, 12 parts of philippine flemingia root.
The preparation method of the Chinese herbal medicine socks is the same as embodiment 2.
Embodiment 6
A kind of Chinese herbal medicine socks for preventing and treating tinea pedis, the socks use herbal composite mixing cotton fiber or bamboo charcoal fiber
It is blended to be made, wherein herbal composite includes the component of following parts by weight: 21 parts of cherokee rose root, 20 parts of Radix Codonopsis, 23 parts of Radix Angelicae Sinensis,
15 parts of Herba Andrographitis, 21 parts of single side needle, 20 parts of leatherleaf mahonia, 17 parts of Caulis Spatholobi, 16 parts of philippine flemingia root.
The preparation method of the Chinese herbal medicine socks is the same as embodiment 3.
Embodiment 7
A kind of Chinese herbal medicine socks for preventing and treating tinea pedis, the socks use herbal composite mixing cotton fiber or bamboo charcoal fiber
It is blended to be made, wherein herbal composite includes the component of following parts by weight: 25 parts of cherokee rose root, 24 parts of Radix Codonopsis, 27 parts of Radix Angelicae Sinensis,
18 parts of Herba Andrographitis, 25 parts of single side needle, 24 parts of leatherleaf mahonia, 20 parts of Caulis Spatholobi, 19 parts of philippine flemingia root, 6 parts of corter pseudolaricis, 10 parts of Cortex Phellodendri, horse
Tassel pellet 11 parts, 10 parts of tea seed cake, 10 parts of rhizoma cyperi, 13 parts of Prunella vulgaris, 11 parts of Rhizoma Chuanxiong, 7 parts of corn stigma, 6 parts of the seed of cowherb, Schisandra chinensis 6
Part, 5 parts of centella, 5 parts of leached tea oil slag, 7 parts of frutus cnidii, 4 parts of radix paeoniae rubra, 3 parts of tripterygium wilfordii, 5 parts of Radix Astragali, 5 parts of Morinda officinalis, 4 parts of schizonepeta,
3 parts of rhizoma anemarrhenae, 2 parts of Armstrong, 2 parts of wartwort, 4 parts of fructus piperis longi, 2 parts of Flos Magnoliae Liliflorae, 3 parts of Asian puccoon, 3 parts of Myriogyne minuta, 3 parts of fructus viticis, wilsonii 4
Part, 3 parts of honeysuckle, 2 parts of gentianae macrophyllae, 2 parts of curcuma zedoary.
The preparation method of the Chinese herbal medicine socks is the same as embodiment 3.
Embodiment 8
A kind of Chinese herbal medicine socks for preventing and treating tinea pedis, the socks use herbal composite mixing cotton fiber or bamboo charcoal fiber
It is blended to be made, wherein herbal composite includes the component of following parts by weight: 25 parts of cherokee rose root, 24 parts of Radix Codonopsis, 27 parts of Radix Angelicae Sinensis,
18 parts of Herba Andrographitis, 25 parts of single side needle, 24 parts of leatherleaf mahonia, 20 parts of Caulis Spatholobi, 19 parts of philippine flemingia root, 10 parts of corter pseudolaricis, 20 parts of Cortex Phellodendri, horse
Tassel pellet 12 parts, 12 parts of tea seed cake, 12 parts of rhizoma cyperi, 15 parts of Prunella vulgaris, 13 parts of Rhizoma Chuanxiong, 9 parts of corn stigma, 8 parts of the seed of cowherb, Schisandra chinensis 8
Part, 7 parts of centella, 6 parts of leached tea oil slag, 7 parts of frutus cnidii, 6 parts of radix paeoniae rubra, 5 parts of tripterygium wilfordii, 5 parts of Radix Astragali, 6 parts of Morinda officinalis, 5 parts of schizonepeta,
4 parts of rhizoma anemarrhenae, 3 parts of Armstrong, 3 parts of wartwort, 5 parts of fructus piperis longi, 3 parts of Flos Magnoliae Liliflorae, 4 parts of Asian puccoon, 4 parts of Myriogyne minuta, 4 parts of fructus viticis, wilsonii 5
Part, 4 parts of honeysuckle, 3 parts of gentianae macrophyllae, 3 parts of curcuma zedoary.
The preparation method of the Chinese herbal medicine socks is the same as embodiment 3.
Embodiment 9
A kind of Chinese herbal medicine socks for preventing and treating tinea pedis, the socks use herbal composite mixing cotton fiber or bamboo charcoal fiber
It is blended to be made, wherein herbal composite includes the component of following parts by weight: 25 parts of cherokee rose root, 24 parts of Radix Codonopsis, 27 parts of Radix Angelicae Sinensis,
10 parts of 18 parts of Herba Andrographitis, 25 parts of single side needle, 24 parts of leatherleaf mahonia, 20 parts of Caulis Spatholobi, 19 parts of philippine flemingia root, 5 parts of corter pseudolaricis, Cortex Phellodendri Ma Ying
Red 8 parts, 8 parts of tea seed cake, 8 parts of rhizoma cyperi, 10 parts of Prunella vulgaris, 9 parts of Rhizoma Chuanxiong, 6 parts of corn stigma, 5 parts of the seed of cowherb, 5 parts of Schisandra chinensis, product
Avenge careless 4 parts, 3 parts of leached tea oil slag, 3 parts of frutus cnidii, 3 parts of radix paeoniae rubra, 2 parts of tripterygium wilfordii, 2 parts of Radix Astragali, 3 parts of Morinda officinalis, 3 parts of schizonepeta, rhizoma anemarrhenae 2
Part, 1 part of Armstrong, 1 part of wartwort, 2 parts of fructus piperis longi, 1 part of Flos Magnoliae Liliflorae, 2 parts of Asian puccoon, 2 parts of Myriogyne minuta, 2 parts of fructus viticis, 2 parts of wilsonii, gold
2 parts of honeysuckle flower, 1 part of gentianae macrophyllae, 1 part of curcuma zedoary.
The preparation method of the Chinese herbal medicine socks is the same as embodiment 3.
10 antibacterial experiment in vitro of embodiment
1, experimental method
(1) fungi: Trichophyton rubrum (Trichophytonrubrum), trichophyton gypseum
(Trichophytonmentagrophytes), acrothesium floccosum (Epidermophytonfloccosum), rosiness hair tinea
Bacterium.
(2) 130 mouse are chosen, totally 13 groups, every group 10, every three groups are inoculated with a kind of fungi modeling.
Modeling method: back unhairing is rubbed at unhairing position using antiseptic gauze repeatedly after the tincture of iodine and 75% alcohol disinfecting
It wipes to there is dotted penetrating fluid for degree, fungi is seeded in back of mice, there is scaling damage in back of mice after modeling 2 weeks,
The warm slabbing erythema of papule takes Fungus examination modeling success under scales of skin that peel off mirror.
(3) it is administered
Two groups of every kind of fungi modeling, wherein one group is not given any drug only with physiological saline bathing for control group
Treatment, another two groups are experimental group respectively after physiological saline bathing, pick the medicine prepared in the step S6 of a small amount of embodiment 1 or 6
Ingredient mixed liquor is imitated, the entire unhairing position of mouse is applied to.In addition, also taking 10 white mouse as blank control group, unhairing
Physiological saline bathing is used afterwards, does not give any drug therapy.Successive administration or physiological saline 4 weeks, 1 fungi was done every 2 days
It checks.
Animal subject group scales of skin that peel off after medication 4 days significantly reduces, and the scales of skin that peel off fades away after medication 10 days, is in pale red color spot,
Skin appearance restores normal after 16 days, and Fungus examination is feminine gender.
3, to the bacteriostatic activity of candida albicans
Effective component mixed liquor used in the present invention is diluted to various concentration, is uniformly applied to Solid media for plates
Surface is inoculated with candida albicans standard bacteria bacterium solution, cultivates visual observations bacterium colony growing state after a period of time.The results show that this
The herbal powder that invention Traditional Chinese medicinal insole uses to the minimum inhibitory concentration of Candida albicans for 50 μ g/ml, to Candida albicans
Bacterium has significant bacteriostasis.
11 safety analysis of embodiment
By taking the effective component mixed liquor of the middle preparation of embodiment 1 and 6 as an example, observe Chinese herbal medicine powder foot couple skin toxicity and
Irritative response.
1, dermal toxicity test
Healthy adult rabbit is taken, if intact skin and damaged skin administration group, and respectively set blank control group.Test medicine connects
Rabbit is touched completely and after damaged skin, measurement breathing, heart rate and four limbs activity etc..
As a result with administration before and comparison among groups, statistically there was no significant difference, also there are no systemic toxicity.
2, skin irritation test
(1) rabbit skin irritation test is used, intact skin group and damage skin group are divided, respectively in the 1d of administration, continuous
After 7d, whether there is or not the stimulate the reactions such as erythema, oedema for observation skin.It is tested, is administered once daily using mouse skin allergy, continuous one
A month, whether there is or not the allergic reactions such as erythema, oedema for observation skin.
(2) the results show that the intact skin and damaged skin of rabbit, remove after being intended for single use or be used for multiple times for 24 hours, point
Not in 1,24,48,72h observation, it is showed no erythema and oedema, stimulate the reaction mean scores are < 0.5, nonirritant.Mouse skin
In allergic experiment, do not occur the cutaneous anaphylaxises such as the obvious erythema of skin, oedema and other systemic anaphylaxises.
Therefore, Chinese herbal medicine powder foot couple rabbit intact skin used in insole of the present invention and damage skin will not cause to stimulate
Property reaction to mouse skin without allergic reaction there is good cutaneous safety.
12 application experiment of embodiment
1, contained according to " Chinese and western medical science diagnostics ", itch caused by tinea pedis disease, pain clinical criteria, selection
250 clinical tinea pedis patients.Wherein 300 patients are uniformly random to be divided into five groups according to coincident with severity degree of condition, age and gender,
Every group of 50 people.
Specific diagnostic criteria: the direct microscopy of fungi is positive；Symptom standard is as follows:
Vesicle: between toe, foot edge, vola there is grain of rice size, it is deep in property blister, evacuation or be distributed in groups, blister wall is thicker,
Content is limpid, is not easily broken, and mutually fusion forms kerionic vesicle, tears blister wall off, it is seen that honeycomb substrate and cerise are rotten to the corn
Face, violent itch.
Erosive type: local horny layer of epidermis soaking is whitened, and cerise erosion surface is exposed in excoriation；Acute pruritus, it is multiple
Between toe seam.
Scales of skin that peel off keratinization type: vola pedis, foot edge, heel portion skin toe thicken, be coarse, furfur, scales of skin that peel off slabbing or small point-like,
It falls off repeatedly.
(2) exclusion criteria: above-mentioned diagnostic criteria person is not met 1)；Though 2) meet above-mentioned standard, there are following feelings simultaneously
The one of condition: pregnant and lying-in women or breast feeding women；Antifungal drug person is taken orally in 3 months；Antimycotic medicine for external application person in 1 month；
To drug allergy person of the present invention.
2, it is grouped situation
Experimental group 1: 1 Chinese herbal medicine socks of embodiment；Experimental group 2: 4 Chinese herbal medicine socks of embodiment；Experimental group 3: in embodiment 6
Herbal medicine socks；Experimental group 4: 7 Chinese herbal medicine socks of embodiment；Control group: common quilted stockings or bamboo fiber sock, each 25 people.
Experiment periods: two french heels weekly, it is continuous to dress, new socks are replaced once a week, patient dresses socks daily.Experiment
Phase was observed to after 6 months.
3, the judgment criteria of therapeutic effect are as follows:
Cure: foot odour, foot itch, furfur, bubble, abscess, the red malaise symptoms such as wet completely disappear, without multiple in half a year
Hair, foot sweat restore normal.
Effective: the malaise symptoms such as foot odour, foot itch, foot sweat mitigate, and have recurrence, need to continue to use this drug.
Invalid: the malaise symptoms such as foot odour, foot itch, foot sweat are not improved.
The judgment criteria of comfort level is divided into:
Comfortable: both feet feel complete indifference or slightly difference, can ignore；
General: both feet feel the difference for having certain, can endure；
Uncomfortable: both feet feel notable difference, are impatient at；
4, result statistics is as shown in table 1,
1 application experiment statistical form of table
Application experiment result explanation, Chinese herbal medicine socks provided by the invention have significant curative effect for treatment tinea pedis, long
Phase uses, and regularly replaces new Chinese herbal medicine socks, can more effectively prevent and treat tinea pedis.The cure rate of experimental group be up to 50% with
On, it can once cure；95% or more total effective rate average out to.
In terms of comfort level, 5 groups of data correlation values are all close, do not differ significantly, illustrate in provided by the invention
Herbal medicine socks compare regular socks, are not significantly different in comfort level, are that one kind is easy to adhere to for tinea pedis patient
The treatment method gone down.
The above embodiment is a preferred embodiment of the present invention, but embodiments of the present invention are not by above-described embodiment
Limitation, other any changes, modifications, substitutions, combinations, simplifications made without departing from the spirit and principles of the present invention,
It should be equivalent substitute mode, be included within the scope of the present invention.
Claims (10)
1. a kind of Chinese herbal medicine socks for preventing and treating tinea pedis, which is characterized in that the socks use herbal composite mixing cotton fiber
Or bamboo charcoal fiber is blended is made, the herbal composite includes the component of following parts by weight: 23~28 parts of cherokee rose root, Radix Codonopsis 20
~29 parts, 24~30 parts of Radix Angelicae Sinensis, 14~19 parts of Herba Andrographitis, 19~30 parts of single side needle, 16~32 parts of leatherleaf mahonia, Caulis Spatholobi 19~24
Part, 12~20 parts of philippine flemingia root.
2. socks according to claim 1, which is characterized in that the Chinese medicine composition includes the component of following parts by weight:
23~25 parts of cherokee rose root, 23~25 parts of Radix Codonopsis, 27~29 parts of Radix Angelicae Sinensis, 17~19 parts of Herba Andrographitis, 23~26 parts of single side needle, leatherleaf mahonia
22~25 parts, 19~22 parts of Caulis Spatholobi, 18~20 parts of philippine flemingia root.
3. socks according to claim 2, which is characterized in that the Chinese medicine composition includes the component of following parts by weight:
It is 25 parts of cherokee rose root, 24 parts of Radix Codonopsis, 27 parts of Radix Angelicae Sinensis, 18 parts of Herba Andrographitis, 25 parts of single side needle, 24 parts of leatherleaf mahonia, 20 parts of Caulis Spatholobi, very heavy
Pull out 19 parts.
4. socks according to claim 3, which is characterized in that the Chinese medicine composition further includes the group of following parts by weight
Point: 5~10 parts of corter pseudolaricis, 10~20 parts of Cortex Phellodendri, 8~12 parts of lantana, 8~12 parts of tea seed cake, 8~12 parts of rhizoma cyperi, Prunella vulgaris 10
~15 parts, 9~13 parts of Rhizoma Chuanxiong, 6~9 parts of corn stigma, 5~8 parts of the seed of cowherb, 5~8 parts of Schisandra chinensis, 4~7 parts of centella, tea seed
3~6 parts of the dregs of rice, 3~7 parts of frutus cnidii, 3~6 parts of radix paeoniae rubra, 2~5 parts of tripterygium wilfordii, 2~5 parts of Radix Astragali, 3~6 parts of Morinda officinalis, schizonepeta 3~
5 parts, 2~4 parts of rhizoma anemarrhenae, 1~3 part of Armstrong, 1~3 part of wartwort, 2~5 parts of fructus piperis longi, 1~3 part of Flos Magnoliae Liliflorae, 2~4 parts of Asian puccoon, stone Hu
2~4 parts of Sui, 2~4 parts of fructus viticis, 2~5 parts of wilsonii, 2~4 parts of honeysuckle, 1~3 part of gentianae macrophyllae, 1~3 part of curcuma zedoary.
5. socks according to claim 4, which is characterized in that the Chinese medicine composition is grouped by the group of following parts by weight
At: 25 parts of cherokee rose root, 24 parts of Radix Codonopsis, 27 parts of Radix Angelicae Sinensis, 18 parts of Herba Andrographitis, 25 parts of single side needle, 24 parts of leatherleaf mahonia, 20 parts of Caulis Spatholobi,
19 parts of philippine flemingia root, 6 parts of corter pseudolaricis, 10 parts of Cortex Phellodendri, 11 parts of lantana, 10 parts of tea seed cake, 10 parts of rhizoma cyperi, 13 parts of Prunella vulgaris, Rhizoma Chuanxiong 11
Part, 7 parts of corn stigma, 6 parts of the seed of cowherb, 6 parts of Schisandra chinensis, 5 parts of centella, 5 parts of leached tea oil slag, 7 parts of frutus cnidii, 4 parts of radix paeoniae rubra, Thunder God
3 parts of rattan, 5 parts of Radix Astragali, 5 parts of Morinda officinalis, 4 parts of schizonepeta, 3 parts of rhizoma anemarrhenae, 2 parts of Armstrong, 2 parts of wartwort, 4 parts of fructus piperis longi, 2 parts of Flos Magnoliae Liliflorae, purple
Careless 3 parts, 3 parts of Myriogyne minuta, 3 parts of fructus viticis, 4 parts of wilsonii, 3 parts of honeysuckle, 2 parts of gentianae macrophyllae, 2 parts of curcuma zedoary.
6. socks according to any one of claims 1 to 5, which is characterized in that the preparation method of the socks includes following step
It is rapid:
S1. it impregnates: cherokee rose root, Radix Codonopsis, Radix Angelicae Sinensis, Herba Andrographitis, single side needle, leatherleaf mahonia, Caulis Spatholobi, philippine flemingia root is utilized respectively water and mentioned
Method or alcohol extracting method carry out effective component extraction, and gained extracting solution merges, and the dregs of a decoction merge stand-by；
S2. it sterilizes: by step S1 Chinese medicine slag and other traditional Chinese medicinal components, by then intermittent low temperature sterilization after being separately dried；
S3. it pre-processes: after product drying to water content 25%~45% in step S2, carrying out Micro-wave pretreatment, for use；
S4. boiling: the pretreated dregs of a decoction are placed in boiling vessel, after ethanol solution is added, is rapidly heated, is put after insulation reaction
Material, obtains coarse particles and cooking liquor；
S5. it washs: the obtained coarse particles of step S4 being placed in displacement washing device, with the ethanol solution of mass concentration 55%~70%
Multistage displacement washing is carried out, cleaning solution ratio is 1:7~8, and wash temperature is 40~60 DEG C；Then it is washed with water completely, after dry
Obtain fibre semi-finished products；
S6. the extraction of effective component: concentration is evaporated to the cooking liquor in step S4, obtains water after recycling of condensed steam ethyl alcohol
Solution is concentrated, and obtaining has effective component solution, is merged with extracting solution in step S1, is obtained effective component mixed liquor；
S7. the fibre semi-finished products of step S5 are soaked in the effective component mixed liquor of step S4, dry, obtaining has pharmacological property
Fiber；
S8. blend fibre line is made into using fiber obtained by step S7 and cotton fiber or bamboo charcoal fiber；
S9. by after blend fibre line is made into embryo cloth in step S8, socks are made.
7. socks according to claim 6, which is characterized in that the sterilising conditions of intermittent low temperature sterilization described in step S2 are
45~55 DEG C moist heat sterilization 2~3 hours, interval 12~20 hours after sterilize again, repeat sterilizing 3~5 times.
8. socks according to claim 6, which is characterized in that the condition of Micro-wave pretreatment described in step S3 is microwave
Power is 900~1500W, and microwave irradiation time is 5~10min.
9. socks according to claim 6, which is characterized in that the solid-liquid ratio of the dregs of a decoction described in step S4 and ethanol solution is
1:4~5；The mass concentration of the ethanol solution is 40%~60%；The warming temperature is 120~140 DEG C；The insulation reaction
It often is 100~120 min.
10. socks according to claim 6, which is characterized in that the mass concentration of ethanol solution described in step S5 is 40%
~60%；The coarse particles and cleaning solution solid-liquid ratio are 1:7~8；The wash temperature is 40~60 DEG C.
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| CN201711358297.9A CN109924553A (en) | 2017-12-17 | 2017-12-17 | A kind of Chinese herbal medicine socks for preventing and treating tinea pedis |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112076259A (en) * | 2020-09-25 | 2020-12-15 | 武汉润禾生物医药有限公司 | Preparation method and application of traditional Chinese medicine ointment for treating tinea pedis |
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| CN105125689A (en) * | 2015-09-21 | 2015-12-09 | 株洲千金药业股份有限公司 | Foot bath powder containing medicine residue of Fuke Qianjin tablets and preparation method of foot bath powder |
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| CN101036716A (en) * | 2006-03-15 | 2007-09-19 | 仁和（集团）发展有限公司 | Method of preparing Chinese traditional medicine composition for curing gynecopathy |
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| CN103535865A (en) * | 2013-10-15 | 2014-01-29 | 常熟市凯博尔纺织品有限公司 | Antibacterial and warmth keeping stocking |
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| CN112076259A (en) * | 2020-09-25 | 2020-12-15 | 武汉润禾生物医药有限公司 | Preparation method and application of traditional Chinese medicine ointment for treating tinea pedis |
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