CN105770099A - Externally applied traditional Chinese medicine for treating tinea corporis and cruris and tinea manus and pedis - Google Patents
Externally applied traditional Chinese medicine for treating tinea corporis and cruris and tinea manus and pedis Download PDFInfo
- Publication number
- CN105770099A CN105770099A CN201610167228.9A CN201610167228A CN105770099A CN 105770099 A CN105770099 A CN 105770099A CN 201610167228 A CN201610167228 A CN 201610167228A CN 105770099 A CN105770099 A CN 105770099A
- Authority
- CN
- China
- Prior art keywords
- tinea
- chinese medicine
- traditional chinese
- externally applied
- pedis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 208000002474 Tinea Diseases 0.000 title claims abstract description 34
- 239000003814 drug Substances 0.000 title claims abstract description 33
- 210000002683 foot Anatomy 0.000 title claims abstract description 28
- 206010067197 Tinea manuum Diseases 0.000 title claims abstract description 24
- 201000004647 tinea pedis Diseases 0.000 title claims abstract description 23
- 201000010618 Tinea cruris Diseases 0.000 title abstract description 4
- 206010005913 Body tinea Diseases 0.000 title abstract 3
- 201000003875 tinea corporis Diseases 0.000 title abstract 3
- 244000276331 Citrus maxima Species 0.000 claims abstract description 18
- 244000166124 Eucalyptus globulus Species 0.000 claims abstract description 18
- 241001646838 Elsholtzia densa Species 0.000 claims abstract description 17
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 16
- 241000130764 Tinea Species 0.000 claims description 28
- 241000905957 Channa melasoma Species 0.000 claims description 19
- 244000307697 Agrimonia eupatoria Species 0.000 claims description 18
- 241000219312 Chenopodium Species 0.000 claims description 18
- 240000003731 Piper cubeba Species 0.000 claims description 18
- 235000002711 Piper cubeba Nutrition 0.000 claims description 17
- 235000000125 common agrimony Nutrition 0.000 claims description 17
- 235000003092 Artemisia dracunculus Nutrition 0.000 claims description 16
- 240000001851 Artemisia dracunculus Species 0.000 claims description 16
- 244000223014 Syzygium aromaticum Species 0.000 claims description 16
- 241001179022 Hydnocarpus anthelminthicus Species 0.000 claims description 15
- 235000016639 Syzygium aromaticum Nutrition 0.000 claims description 15
- 239000002994 raw material Substances 0.000 claims description 7
- 230000000694 effects Effects 0.000 abstract description 19
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 10
- 201000010099 disease Diseases 0.000 abstract description 9
- 239000008280 blood Substances 0.000 abstract description 7
- 210000004369 blood Anatomy 0.000 abstract description 7
- 230000003902 lesion Effects 0.000 abstract description 5
- 229940121375 antifungal agent Drugs 0.000 abstract description 3
- 239000003429 antifungal agent Substances 0.000 abstract description 3
- 235000001759 Citrus maxima Nutrition 0.000 abstract 1
- 241000628997 Flos Species 0.000 abstract 1
- 230000008595 infiltration Effects 0.000 abstract 1
- 238000001764 infiltration Methods 0.000 abstract 1
- 210000000582 semen Anatomy 0.000 abstract 1
- 239000000341 volatile oil Substances 0.000 description 27
- 241000894006 Bacteria Species 0.000 description 12
- 238000000605 extraction Methods 0.000 description 12
- 239000000463 material Substances 0.000 description 12
- 210000003491 skin Anatomy 0.000 description 11
- 238000002360 preparation method Methods 0.000 description 10
- 241000233866 Fungi Species 0.000 description 9
- 238000005516 engineering process Methods 0.000 description 9
- 239000000203 mixture Substances 0.000 description 8
- 235000004692 Eucalyptus globulus Nutrition 0.000 description 7
- 230000000844 anti-bacterial effect Effects 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- 239000003921 oil Substances 0.000 description 7
- 235000019134 Eucalyptus tereticornis Nutrition 0.000 description 6
- 229940079593 drug Drugs 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 206010063409 Acarodermatitis Diseases 0.000 description 5
- 208000003251 Pruritus Diseases 0.000 description 5
- 241000447727 Scabies Species 0.000 description 5
- 208000005687 scabies Diseases 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 206010007247 Carbuncle Diseases 0.000 description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 208000032843 Hemorrhage Diseases 0.000 description 4
- 208000002193 Pain Diseases 0.000 description 4
- 230000000843 anti-fungal effect Effects 0.000 description 4
- 230000001139 anti-pruritic effect Effects 0.000 description 4
- 239000003908 antipruritic agent Substances 0.000 description 4
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 description 4
- 229930003944 flavone Natural products 0.000 description 4
- 150000002213 flavones Chemical class 0.000 description 4
- 235000011949 flavones Nutrition 0.000 description 4
- 239000011521 glass Substances 0.000 description 4
- 208000015181 infectious disease Diseases 0.000 description 4
- 230000036407 pain Effects 0.000 description 4
- 230000037380 skin damage Effects 0.000 description 4
- 206010015150 Erythema Diseases 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 3
- 240000002262 Litsea cubeba Species 0.000 description 3
- 241000893976 Nannizzia gypsea Species 0.000 description 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
- 206010033733 Papule Diseases 0.000 description 3
- 241000223229 Trichophyton rubrum Species 0.000 description 3
- 241000893966 Trichophyton verrucosum Species 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 230000000740 bleeding effect Effects 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 239000012153 distilled water Substances 0.000 description 3
- 231100000321 erythema Toxicity 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 238000011081 inoculation Methods 0.000 description 3
- 239000003208 petroleum Substances 0.000 description 3
- 210000002784 stomach Anatomy 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 2
- 235000010894 Artemisia argyi Nutrition 0.000 description 2
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 239000005770 Eugenol Substances 0.000 description 2
- GLZPCOQZEFWAFX-UHFFFAOYSA-N Geraniol Chemical compound CC(C)=CCCC(C)=CCO GLZPCOQZEFWAFX-UHFFFAOYSA-N 0.000 description 2
- 206010062717 Increased upper airway secretion Diseases 0.000 description 2
- 206010024229 Leprosy Diseases 0.000 description 2
- 235000012854 Litsea cubeba Nutrition 0.000 description 2
- 239000007832 Na2SO4 Substances 0.000 description 2
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 125000001931 aliphatic group Chemical group 0.000 description 2
- 229930013930 alkaloid Natural products 0.000 description 2
- 150000003797 alkaloid derivatives Chemical class 0.000 description 2
- 230000036592 analgesia Effects 0.000 description 2
- 230000003266 anti-allergic effect Effects 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- 235000006708 antioxidants Nutrition 0.000 description 2
- 238000003491 array Methods 0.000 description 2
- 244000030166 artemisia Species 0.000 description 2
- 208000006673 asthma Diseases 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- -1 carypohyllene Chemical compound 0.000 description 2
- NEHNMFOYXAPHSD-UHFFFAOYSA-N citronellal Chemical compound O=CCC(C)CCC=C(C)C NEHNMFOYXAPHSD-UHFFFAOYSA-N 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 230000029087 digestion Effects 0.000 description 2
- 238000007599 discharging Methods 0.000 description 2
- 208000001848 dysentery Diseases 0.000 description 2
- 210000002615 epidermis Anatomy 0.000 description 2
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 description 2
- 229960002217 eugenol Drugs 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 229930003935 flavonoid Natural products 0.000 description 2
- 150000002215 flavonoids Chemical class 0.000 description 2
- 235000017173 flavonoids Nutrition 0.000 description 2
- 230000002538 fungal effect Effects 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 230000023597 hemostasis Effects 0.000 description 2
- 241000411851 herbal medicine Species 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 description 2
- 229940040145 liniment Drugs 0.000 description 2
- 239000000865 liniment Substances 0.000 description 2
- 201000004792 malaria Diseases 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- 244000045947 parasite Species 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 208000026435 phlegm Diseases 0.000 description 2
- 150000003904 phospholipids Chemical class 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 238000010298 pulverizing process Methods 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 238000005057 refrigeration Methods 0.000 description 2
- 229910052938 sodium sulfate Inorganic materials 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 238000000194 supercritical-fluid extraction Methods 0.000 description 2
- 229920001864 tannin Chemical class 0.000 description 2
- 235000018553 tannin Nutrition 0.000 description 2
- 239000001648 tannin Chemical class 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 229940098465 tincture Drugs 0.000 description 2
- 230000000699 topical effect Effects 0.000 description 2
- 150000003648 triterpenes Chemical class 0.000 description 2
- 238000010792 warming Methods 0.000 description 2
- XMAYWYJOQHXEEK-OZXSUGGESA-N (2R,4S)-ketoconazole Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 description 1
- 239000001490 (3R)-3,7-dimethylocta-1,6-dien-3-ol Substances 0.000 description 1
- CDOSHBSSFJOMGT-JTQLQIEISA-N (R)-linalool Natural products CC(C)=CCC[C@@](C)(O)C=C CDOSHBSSFJOMGT-JTQLQIEISA-N 0.000 description 1
- OCAPBUJLXMYKEJ-UHFFFAOYSA-N 1-[biphenyl-4-yl(phenyl)methyl]imidazole Chemical compound C1=NC=CN1C(C=1C=CC(=CC=1)C=1C=CC=CC=1)C1=CC=CC=C1 OCAPBUJLXMYKEJ-UHFFFAOYSA-N 0.000 description 1
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 1
- LEZWWPYKPKIXLL-UHFFFAOYSA-N 1-{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl}imidazole Chemical compound C1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 LEZWWPYKPKIXLL-UHFFFAOYSA-N 0.000 description 1
- VHVPQPYKVGDNFY-DFMJLFEVSA-N 2-[(2r)-butan-2-yl]-4-[4-[4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N([C@H](C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-DFMJLFEVSA-N 0.000 description 1
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 241001278836 Agrimonia pilosa Species 0.000 description 1
- 235000000641 Agrimonia pilosa Nutrition 0.000 description 1
- 241001465677 Ancylostomatoidea Species 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 241001480043 Arthrodermataceae Species 0.000 description 1
- 241000244203 Caenorhabditis elegans Species 0.000 description 1
- 241000871189 Chenopodiaceae Species 0.000 description 1
- 244000281762 Chenopodium ambrosioides Species 0.000 description 1
- 235000000509 Chenopodium ambrosioides Nutrition 0.000 description 1
- WTEVQBCEXWBHNA-UHFFFAOYSA-N Citral Natural products CC(C)=CCCC(C)=CC=O WTEVQBCEXWBHNA-UHFFFAOYSA-N 0.000 description 1
- 241001478240 Coccus Species 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- PQMOXTJVIYEOQL-UHFFFAOYSA-N Cumarin Natural products CC(C)=CCC1=C(O)C(C(=O)C(C)CC)=C(O)C2=C1OC(=O)C=C2CCC PQMOXTJVIYEOQL-UHFFFAOYSA-N 0.000 description 1
- 208000001840 Dandruff Diseases 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- IIUZTXTZRGLYTI-UHFFFAOYSA-N Dihydrogriseofulvin Natural products COC1CC(=O)CC(C)C11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 IIUZTXTZRGLYTI-UHFFFAOYSA-N 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- AFSDNFLWKVMVRB-UHFFFAOYSA-N Ellagic acid Chemical compound OC1=C(O)C(OC2=O)=C3C4=C2C=C(O)C(O)=C4OC(=O)C3=C1 AFSDNFLWKVMVRB-UHFFFAOYSA-N 0.000 description 1
- ATJXMQHAMYVHRX-CPCISQLKSA-N Ellagic acid Natural products OC1=C(O)[C@H]2OC(=O)c3cc(O)c(O)c4OC(=O)C(=C1)[C@H]2c34 ATJXMQHAMYVHRX-CPCISQLKSA-N 0.000 description 1
- 229920002079 Ellagic acid Polymers 0.000 description 1
- 208000004232 Enteritis Diseases 0.000 description 1
- 201000000297 Erysipelas Diseases 0.000 description 1
- 241000266331 Eugenia Species 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 206010016326 Feeling cold Diseases 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 239000005792 Geraniol Substances 0.000 description 1
- GLZPCOQZEFWAFX-YFHOEESVSA-N Geraniol Natural products CC(C)=CCC\C(C)=C/CO GLZPCOQZEFWAFX-YFHOEESVSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- UXWOXTQWVMFRSE-UHFFFAOYSA-N Griseoviridin Natural products O=C1OC(C)CC=C(C(NCC=CC=CC(O)CC(O)C2)=O)SCC1NC(=O)C1=COC2=N1 UXWOXTQWVMFRSE-UHFFFAOYSA-N 0.000 description 1
- 206010019909 Hernia Diseases 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 201000008197 Laryngitis Diseases 0.000 description 1
- 239000000232 Lipid Bilayer Substances 0.000 description 1
- FSOGIJPGPZWNGO-UHFFFAOYSA-N Meomammein Natural products CCC(C)C(=O)C1=C(O)C(CC=C(C)C)=C(O)C2=C1OC(=O)C=C2CCC FSOGIJPGPZWNGO-UHFFFAOYSA-N 0.000 description 1
- BYBLEWFAAKGYCD-UHFFFAOYSA-N Miconazole Chemical compound ClC1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 BYBLEWFAAKGYCD-UHFFFAOYSA-N 0.000 description 1
- 241000893980 Microsporum canis Species 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- 241000219926 Myrtaceae Species 0.000 description 1
- DDUHZTYCFQRHIY-UHFFFAOYSA-N Negwer: 6874 Natural products COC1=CC(=O)CC(C)C11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 DDUHZTYCFQRHIY-UHFFFAOYSA-N 0.000 description 1
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 description 1
- 239000001888 Peptone Substances 0.000 description 1
- 108010080698 Peptones Proteins 0.000 description 1
- 208000008350 Pruritus Vulvae Diseases 0.000 description 1
- 241000218998 Salicaceae Species 0.000 description 1
- 208000007107 Stomach Ulcer Diseases 0.000 description 1
- 208000007712 Tinea Versicolor Diseases 0.000 description 1
- 206010049591 Tinea imbricata Diseases 0.000 description 1
- 206010056131 Tinea versicolour Diseases 0.000 description 1
- 206010044565 Tremor Diseases 0.000 description 1
- 206010046788 Uterine haemorrhage Diseases 0.000 description 1
- 206010056530 Vulvovaginal pruritus Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 229960000583 acetic acid Drugs 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 239000003470 adrenal cortex hormone Substances 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 150000001336 alkenes Chemical class 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 230000000146 antalgic effect Effects 0.000 description 1
- PYKYMHQGRFAEBM-UHFFFAOYSA-N anthraquinone Natural products CCC(=O)c1c(O)c2C(=O)C3C(C=CC=C3O)C(=O)c2cc1CC(=O)OC PYKYMHQGRFAEBM-UHFFFAOYSA-N 0.000 description 1
- 150000004056 anthraquinones Chemical class 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000001142 anti-diarrhea Effects 0.000 description 1
- 230000000078 anti-malarial effect Effects 0.000 description 1
- 230000001857 anti-mycotic effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 239000003430 antimalarial agent Substances 0.000 description 1
- 239000002543 antimycotic Substances 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 229960002206 bifonazole Drugs 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000001217 buttock Anatomy 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 230000002279 cholagogic effect Effects 0.000 description 1
- OTAFHZMPRISVEM-UHFFFAOYSA-N chromone Chemical compound C1=CC=C2C(=O)C=COC2=C1 OTAFHZMPRISVEM-UHFFFAOYSA-N 0.000 description 1
- 208000017580 chronic wasting disease Diseases 0.000 description 1
- 229940043350 citral Drugs 0.000 description 1
- 229930003633 citronellal Natural products 0.000 description 1
- 235000000983 citronellal Nutrition 0.000 description 1
- 229960004022 clotrimazole Drugs 0.000 description 1
- VNFPBHJOKIVQEB-UHFFFAOYSA-N clotrimazole Chemical compound ClC1=CC=CC=C1C(N1C=NC=C1)(C=1C=CC=CC=1)C1=CC=CC=C1 VNFPBHJOKIVQEB-UHFFFAOYSA-N 0.000 description 1
- 239000010634 clove oil Substances 0.000 description 1
- 230000024203 complement activation Effects 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 210000000736 corneocyte Anatomy 0.000 description 1
- ZYGHJZDHTFUPRJ-UHFFFAOYSA-N coumarin Chemical compound C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
- 230000006837 decompression Effects 0.000 description 1
- 230000037304 dermatophytes Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 229960003913 econazole Drugs 0.000 description 1
- 229960002852 ellagic acid Drugs 0.000 description 1
- 235000004132 ellagic acid Nutrition 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 206010014881 enterobiasis Diseases 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 125000001033 ether group Chemical group 0.000 description 1
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 229930182486 flavonoid glycoside Natural products 0.000 description 1
- 150000007955 flavonoid glycosides Chemical class 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 201000005917 gastric ulcer Diseases 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- WTEVQBCEXWBHNA-JXMROGBWSA-N geranial Chemical compound CC(C)=CCC\C(C)=C\C=O WTEVQBCEXWBHNA-JXMROGBWSA-N 0.000 description 1
- 229940113087 geraniol Drugs 0.000 description 1
- 239000012362 glacial acetic acid Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229930182478 glucoside Natural products 0.000 description 1
- 150000008131 glucosides Chemical class 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- DDUHZTYCFQRHIY-RBHXEPJQSA-N griseofulvin Chemical compound COC1=CC(=O)C[C@@H](C)[C@@]11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 DDUHZTYCFQRHIY-RBHXEPJQSA-N 0.000 description 1
- 229960002867 griseofulvin Drugs 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- CATSNJVOTSVZJV-UHFFFAOYSA-N heptan-2-one Chemical compound CCCCCC(C)=O CATSNJVOTSVZJV-UHFFFAOYSA-N 0.000 description 1
- 230000002218 hypoglycaemic effect Effects 0.000 description 1
- 150000002460 imidazoles Chemical class 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 208000021267 infertility disease Diseases 0.000 description 1
- 206010022000 influenza Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 229960004130 itraconazole Drugs 0.000 description 1
- 229960004125 ketoconazole Drugs 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 150000002596 lactones Chemical class 0.000 description 1
- 239000010985 leather Substances 0.000 description 1
- 229930013686 lignan Natural products 0.000 description 1
- 235000009408 lignans Nutrition 0.000 description 1
- 229920005610 lignin Polymers 0.000 description 1
- 229930007744 linalool Natural products 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- FAARLWTXUUQFSN-UHFFFAOYSA-N methylellagic acid Natural products O1C(=O)C2=CC(O)=C(O)C3=C2C2=C1C(OC)=C(O)C=C2C(=O)O3 FAARLWTXUUQFSN-UHFFFAOYSA-N 0.000 description 1
- JPTOCTSNXXKSSN-UHFFFAOYSA-N methylheptenone Chemical compound CCCC=CC(=O)CC JPTOCTSNXXKSSN-UHFFFAOYSA-N 0.000 description 1
- 229960002509 miconazole Drugs 0.000 description 1
- 201000002266 mite infestation Diseases 0.000 description 1
- 230000001114 myogenic effect Effects 0.000 description 1
- DFPMSGMNTNDNHN-ZPHOTFPESA-N naringin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](OC=2C=C3O[C@@H](CC(=O)C3=C(O)C=2)C=2C=CC(O)=CC=2)O[C@H](CO)[C@@H](O)[C@@H]1O DFPMSGMNTNDNHN-ZPHOTFPESA-N 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 210000002640 perineum Anatomy 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 238000013139 quantization Methods 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 206010039083 rhinitis Diseases 0.000 description 1
- 230000005070 ripening Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- 238000007790 scraping Methods 0.000 description 1
- 210000000697 sensory organ Anatomy 0.000 description 1
- 231100000046 skin rash Toxicity 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 238000001256 steam distillation Methods 0.000 description 1
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 230000003637 steroidlike Effects 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 208000006379 syphilis Diseases 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- RBNWAMSGVWEHFP-UHFFFAOYSA-N trans-p-Menthane-1,8-diol Chemical compound CC(C)(O)C1CCC(C)(O)CC1 RBNWAMSGVWEHFP-UHFFFAOYSA-N 0.000 description 1
- 150000008130 triterpenoid saponins Chemical class 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
- 210000004916 vomit Anatomy 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000003878 whitfield ointment Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
Abstract
The invention discloses an externally applied traditional Chinese medicine for treating tinea corporis and cruris and tinea manus and pedis. The externally applied traditional Chinese medicine is prepared from, by mass, 18-26% of Eucalyptus globules fruits, 14-20% of Herba Agrimoniae, 12-28% of Elsholtzia densa, 12-18% of Citrus Grandis peel, 10-16% of Folium Artemisiae Argyi, 7-11% of Herba Chenopodii, 3-5% of Flos Caryophylli, 3-5% of Fructrs Litseae and 0.8-1.2% of Semen Hydnocarpi Anthelminticae. The externally applied traditional Chinese medicine can be directly spread to affected parts and is excellent in skin infiltration effect and capable of directly reaching lesions to function in damp and heat clearing, blood dryness removing and evil wind extinguishing, so that diseases can be self cured due to Qi and blood richness and skin moistening and nourishing. Furthermore, the externally applied traditional Chinese medicine is specially used for treatment of tinea corporis and cruris and tinea manus and pedis well reacted to local antifungal agents.
Description
Technical field
The present invention relates to a kind of external application Chinese medicine treating tinea pedis and manus and tinea of feet and hands, belong to biological pharmacy technical field.
Background technology
Ringworm of the body refers in addition to tinea of feet and hands, tinea versicolor, tinea imbricata, betides even skin and (is apt to occur in the portions such as face, neck, trunk
Position) superficial mycoses, if ringworm of the body betides inner side person on thigh, be also called jock itch, buttocks, perineum etc. can be spread to.Hand
Tinea, tinea pedis are then that dermatophyte is invaded the palm sole of the foot, referred to epidermis between (toe), the mycotic infection of superficial part disease caused.Tinea pedis and manus and hand
Tinea pedis belongs to fungal dermatopathy, and pathogenic bacteria are mainly Trichophyton rubrum, acrothesium floccosum, trichophyton gypseum, white
Read coccus, microsporum canis etc..Often being caused by contact infection, as the sick cat of tinea and dog are suffered from contact, contact tinea patient pollute
Clothing, shares foot basin, slippers, pond etc. with tinea patient.
Tinea pedis and manus and tinea of feet and hands can betide the patient at any age, owing to pathomycete is different and individual difference, patient
Skin damage feature and clinical manifestation and be not quite similar.Clinical treatment based on antimycotic, antipruritic, prevent infection, strengthening artificial satellite
While raw, reinforcement preventing and treating is nursed, emphasis uses imidazoles, Allylamines, dye class, many alkenes and other externally applied drugs treatment,
Such as the compound thunder pungent liniment of lock, glacial acetic acid solution, clotrimazole cream, econazole frost, Miconazole frost, bifonazole is white, ketoconazole is white, special
Than naphthalene sweet smell ointment, whitfield ointment etc..Skin is damaged to the tinea disease of external used medicine unsatisfactory curative effect extensive, simple, recurrent exerbation
Patient, the antifungal drug of the general such as oral administration Itraconazole, griseofulvin.
In recent years, owing to people-to-people contacts increase, directly or indirectly the chance of contact tinea patient increases.On the other hand,
Broad-spectrum antibiotic, corticosteroid hormone, immunodepressant and radiotherapy chemotherapy commonly used so that under body resistivity
Fall.Additionally, increasing substantially occurs in the patient numbers of diabetes and some chronic wasting diseases, the susceptible all kinds of tinea of this kind of crowd
Disease.Thus, tinea pedis and manus and tinea of feet and hands are in increasing trend, and a lot of case to traditional treatment Drug-resistant occur.And Western medicine is controlled
Treatment fungi kind is rare, toxic and side effect is big and expensive.Development of new safely and effectively and be not easy to produce drug resistance
Treatment tinea pedis and manus, the tcm product of tinea of feet and hands, have realistic meaning.
Summary of the invention
It is an object of the invention to provide a kind of external application Chinese medicine treating tinea pedis and manus and tinea of feet and hands, make lesions of patients disappear or
Person alleviates, negative fungal examination.
Further object is that the preparation method that a kind of external application Chinese medicine treating tinea pedis and manus and tinea of feet and hands is provided.
The present invention is completed by following technical proposal: a kind of external application Chinese medicine treating tinea pedis and manus and tinea of feet and hands, it is by following
The raw material of mass percent prepares:
Eucalyptus globules fruits 18-26%
Hairyvein agrimony 14-20%
Elsholtzia densa 12-18%
Pomelo peel 12-18%
Tarragon 10-16%
Chenopodium ambrosiodies 7-11%
Cloves 3-5%
Piper cubeba 3-5%
Chaulmoogra benevolence 0.8-1.2%.
Wherein, Eucalyptus globules fruits is the fruit of Myrtaceae eucalyptus plant blue gum Eucalyptus globulus Labill..Tool
Having a function that wind-dispelling heat-dissipating, inhibiting bacteria and diminishing inflammation, anticorrosion are antipruritic, among the people that to be used for treating flu, dysentery, enteritis, arthralgia, burn boiling hot is more
Wound, skin eczema, Ji tinea, erysipelas, wet epidemic disease and carbuncle epidemic disease pyogenic infections etc..Chemical composition in blue gum mainly has volatile oil, isophthalic three
Amphyl, flavonoids, triterpenes, tannin acids and other compounds.Volatile oil is the main component of blue gum, its kind and
Quantity is more, has isoreactivity antibacterial, anti-oxidant.Consumption: 9-15 gram.
Hairyvein agrimony is the top dryly of rose family agrimony hairyvein agrimony Agrimonia pilosa Ledeb.
Point.There is astringing to arrest bleeding, preventing malaria, only dysentery, effect of removing toxic substances, swell for various haemorrhages, malaria, de-power internal lesion caused by overexertion, carbuncle clinically
Sore, pruritus vulvae band are inferior.Modern medicine and pharmacology research proves: contains volatile oil, phenol, ester, flavones, tannin, glucosides in hairyvein agrimony, have
The chemical compositions such as machine acid, triterpenoid saponin, and there is antitumor, antibacterial, hypoglycemic, antalgic and inflammation relieving, hemostasis, antimalarial, the anti-rhythm of the heart lose
Many pharmacological actions such as often.Consumption: 6-12 gram.
Elsholtzia densa is the herb of Labiatae Elsholtzia species Elsholtzia densa Elsholizia densa Benth, has and disappears
Inflammation, myogenic, hemostasis, antipruritic, effect of removing the rotten and letting fresh grow, can treat that stomach trouble, sore scabies, plum property of medicine rhinitis, laryngitis, sore scabies carbuncle be swollen, skin
Skin itch etc..Containing materials such as protein, carbohydrate, organic acid, flavones, saponin(e, cumarin and lactone, anthraquinone, volatile oil, mainly
Effective component is volatile oil.Consumption: 3-10 gram (consumption with reference to belonging to medicinal plant elscholtiza together).
Pomelo peel is the pericarp of Rutaceae Citrus shaddock Citrus maxima.Have that anti-inflammatory is fungi-proofing, preventing phlegm from forming and stopping coughing, reason
Gas gut purge, lower gas help digestion, effects such as invigorating the spleen of enriching blood.Containing various active composition, such as: volatile oil, aurantiin, pectin, pigment
Deng.Pomelo peel volatile oil smell Fang Ya, can be used for preventing and treating and killing insect.Consumption: 3-10 gram (with reference to pericarp class medicine dried orange peel
Consumption).
Tarragon derives from the dry leaf of composite family sagebruss Chinese mugwort Ariemisa argyi Levl.et vant, has to dissipate and trembles with fear
Pain relieving, the effect of warming channel for arresting bleeding.For few abdomen crymodynia, through cold uncomfortable, palace is cold infertile, spits blood, and bleeding from five sense organs or subcutaneous tissue, uterine bleeding is through many, under gestation
Blood；Control outward pruitus.The main chemical compositions of tarragon is flavones, polysaccharide, volatile oil etc..The volatile oil tool extracted from tarragon
There is antibacterial, antiallergy, relieving asthma, antibechic, dissolving phlegm, protect liver cholagogic, promote the effects such as digestion and complement activation.Consumption: 3-9 gram.
Chenopodium ambrosiodies is complete with fruit ear of Chenopodiaceae genus Chenopodium chenopodium ambrosiodies Chenopodium ambrosioides L.
Grass.Have dispel rheumatism, effect that detumescence and promoting granulation, desinsection are antipruritic.Wet for treating roundworm disease, hookworm disease, enterobiasis, skin
Rash, ringworm itch, and kill maggot.The main chemical compositions of chenopodium ambrosiodies is: volatile oil, flavonoid glycoside, oxalic acid, citric acid and inorganic salts
Deng.Chenopodium ambrosiodies volatile oil has analgesia, calm, antibacterial, desinsection, inhibition cancer cell grow effect and the effect for the treatment of gastric ulcer.
Consumption: 3-6 gram.
Cloves is the dry flower of Myrtaceae Eugenia plant of clove Eugenia caryophyllata Thunb..
Function temperature drops inverse, tonify the kidney and support yang.Its active ingredient volatile oil accounting 14%-21%, is mainly composed of eugenol, eugenol in oil
Acetate, carypohyllene, methyl amyl ketone etc..Cloves is possibly together with chromone, flavones and triterpenes components.Volatile clove oil has
The effects such as antibacterial, anti-inflammatory, analgesia, antidiarrheal, anti-oxidant, suppression tumour.Consumption: 1-3 gram.
Piper cubeba is the drying and ripening fruit of Lauraceae Litsea plant cubeb litsen tree Litsea cubeba (Lour.) Pers.
Real, have another name called the fruit of a cubeb litsea tree.Containing chemical compositions such as alkaloid, aliphatic acid, acid amides, steroidal, lignin.There is warming spleen and stomach for dispelling cold, promoting the circulation of qi
Effect of pain relieving, cures mainly cold hernia stomachache, coldness and pain in the epigastrium, stomach cold vomit inverse, stagnancy of cold-damp etc..Piper cubeba volatile oil has the perfume (or spice) of grace
Gas, its be mainly composed of citral, terpinol, linalool, methyl heptenone, citronellal, geraniol, to scattered ellagic acid etc., have
Anticancer, antibacterial, relieving asthma, the multiple effect such as antiallergy and expelling parasite.Consumption: 1-3 gram.
Chaulmoogra benevolence is Flacourtiaceae Hydnocarpus plant chaulmoogra Hydnocarpu anthelmintica Pierre
It is dried kind of a benevolence.Have and dispel pathogenic wind and remove dampness, effect of detoxicating and destroying parasites.For treating leprosy, mange, syphilis.Containing aliphatic category, Huang
The chemical compositions such as ketone lignans class, flavonoids, lignanoid and alkaloid.Oil compounds has the activity of antibacterial desinsection.With
Amount: 0.3-1 gram.
The consumption of above Chinese medicine means that (concrete numerical value derives from " Chinese Pharmacopoeia " 2010 to adult's one daily dosage for oral administration
Version, " whole nation Chinese herbal medicine compilation " and " China's book on Chinese herbal medicine "), owing to the present invention is external application Chinese medicine, can the most suitably increase use
Amount.In order to take into account validity and security, and realizing the quantization of medication, the present invention is with the oral consumption upper dosage limit of ingredients
Being used as medicine, crude drug amount used by everyone every day of being i.e. grown up is: Eucalyptus globules fruits 15g, hairyvein agrimony 12g, Elsholtzia densa 10g, pomelo peel 10g, Chinese mugwort
Leaf 9g, chenopodium ambrosiodies 6g, cloves 3g, piper cubeba 3g, chaulmoogra benevolence 1g.It is converted into percentage, is: Eucalyptus globules fruits 22%, hairyvein agrimony
17%, Elsholtzia densa 15%, pomelo peel 15%, tarragon 13%, chenopodium ambrosiodies 9%, cloves 4%, piper cubeba 4%, chaulmoogra benevolence 1%.Chinese medicine system
Agent, raw-material active ingredient typically allow to exist the deviation of ± 20%, so technical scheme feature expands to: blue
Eucalyptus fruit 18-26%, hairyvein agrimony 14-20%, Elsholtzia densa 12-18%, pomelo peel 12-18%, tarragon 10-16%, chenopodium ambrosiodies 7-11%, fourth
Fragrant 3-5%, piper cubeba 3-5%, chaulmoogra benevolence 0.8-1.2%.
Second object of the present invention is achieved through the following technical solutions: in a kind of external application treating tinea pedis and manus and tinea of feet and hands
The preparation method of medicine, it is through each processing step following:
A, by following mass percent feeding:
Eucalyptus globules fruits 18-26%
Hairyvein agrimony 14-20%
Elsholtzia densa 12-18%
Pomelo peel 12-18%
Tarragon 10-16%
Chenopodium ambrosiodies 7-11%
Cloves 3-5%
Piper cubeba 3-5%
Chaulmoogra benevolence 0.8-1.2%；
B, above-mentioned medicinal material is broken into medicinal powder, is respectively adopted steam distillation, supercritical CO2Extraction or the method for organic solvent extraction
Prepare the volatile oil of above-mentioned medicinal material.Directly use above-mentioned volatile oil, or add appropriate pharmaceutic adjuvant, use conventional formulation
Method, be prepared as the external application Chinese medicines such as tincture, ointment, emplastrum, cataplasm, aerosol, washing lotion, liniment with treatment tinea pedis and manus or
Person's tinea of feet and hands.
Chinese medicine used by the present invention, have dispel skin scabies leprosy, treatment sore scabies carbuncle swells, mould broken heavily fortified point of flesh, clearing damp heat extraction, scattered
The effects such as heat detumescence, change poison pain relieving, have the use among the people tradition for the treatment of skin tinea, and have through modern pharmacology experiment proof
Significantly antifungal activity.By this nine traditional Chinese medicines material reasonable compatibility, extracting principle active component therein---volatile oil is prepared as
External preparation.And the terpene of one of phytovolatilization main body of oil has notable transdermal facilitation, its transdermal enhancing effect is main
Derive from the upset of the intercellular phospholipid arrays of Stratum Corneum, change corneocyte class lipid bilayer structure, increase it
Mobility, but the upset of the phospholipid arrays caused is of short duration recoverable, thus there is hypotoxicity, high promote saturating property, low use
Amount and the bland feature to skin.The external preparation of the present invention is applied directly to affected part, and transdermal effect is good, will
Through disease is played a role, then clearing moist heat, blood dry go, evil wind breath, qi and blood fills, and skin is moistened foster, disease self-healing, special for treating
To the topical antifungal agents good tinea pedis and manus of reaction, tinea of feet and hands.
Detailed description of the invention
Below by embodiment, the present invention is described in further detail, but scope is not limited to described interior
Hold.
Embodiment 1: the external application Chinese medicine of this treatment tinea pedis and manus and tinea of feet and hands is prepared by the raw material of following masses percentage: blue gum
Really 22%, hairyvein agrimony 17%, Elsholtzia densa 15%, pomelo peel 15%, tarragon 13%, chenopodium ambrosiodies 9%, cloves 4%, piper cubeba 4%, chaulmoogra
Benevolence 1%；
Concrete preparation technology is as follows:
A, medicinal material is cleaned, dry, pulverize after, by following formula feeding: Eucalyptus globules fruits 15g, hairyvein agrimony 12g, Elsholtzia densa 10g,
Pomelo peel 10g, tarragon 9g, chenopodium ambrosiodies 6g, cloves 3g, piper cubeba 3g, chaulmoogra benevolence 1g.
B, through following preparation technology:
The pulverizing medicinal materials thing weighed is added CO2The extraction kettle of supercritical extraction unit, in extracting pressure 40MPa, extraction temperature
Under conditions of 45 DEG C after dynamic extraction 2h, receive the volatile oil of extraction from discharging opening, load lucifuge refrigeration in Brown Glass Brown glass bottles and jars only, standby
With.
Embodiment 2: the external application Chinese medicine of this treatment tinea pedis and manus and tinea of feet and hands is prepared by the raw material of following masses percentage: blue gum
Really 22%, hairyvein agrimony 17%, Elsholtzia densa 15%, pomelo peel 15%, tarragon 13%, chenopodium ambrosiodies 9%, cloves 4%, piper cubeba 4%, chaulmoogra
Benevolence 1%；
Concrete technology is as follows:
A, medicinal material is cleaned, dry, pulverize after, by following formula feeding: Eucalyptus globules fruits 15g, hairyvein agrimony 12g, Elsholtzia densa 10g,
Pomelo peel 10g, tarragon 9g, chenopodium ambrosiodies 6g, cloves 3g, piper cubeba 3g, chaulmoogra benevolence 1g.
B, through following preparation technology:
(1) in load weighted medicinal material, 300mL petroleum ether is added, micro-under conditions of microwave power 1000W, extraction temperature 90 DEG C
Ripple extraction 30min, filters, with 50mL petroleum ether residue, refilters, merging filtrate, through decompression Distillation recovery petroleum ether, oil
Shape thing anhydrous Na2SO4It is dried；
(2) step (1) gained volatile oil is diluted to 30mL with 80% ethanol solution, is prepared as tincture.
Embodiment 3: the external application Chinese medicine of this treatment tinea pedis and manus and tinea of feet and hands is prepared by the raw material of following masses percentage: blue gum
Really 19.5%, hairyvein agrimony 17.1%, Elsholtzia densa 14.6%, pomelo peel 14.6%, tarragon 14.6%, chenopodium ambrosiodies 8.8%, cloves 4.9%,
Piper cubeba 4.9%, chaulmoogra benevolence 1%；
Concrete technology is as follows:
A, medicinal material is cleaned, dry, pulverize after, by following formula feeding: Eucalyptus globules fruits 40g, hairyvein agrimony 35g, Elsholtzia densa 30g,
Pomelo peel 30g, tarragon 30g, chenopodium ambrosiodies 18g, cloves 10g, piper cubeba 10g, chaulmoogra benevolence 2g.
B, through following preparation technology:
(1) load weighted medicinal material is mixed, after a small amount of distilled water immersion 12h, be transferred in the round-bottomed flask of 5000ml, add
The distilled water of 10 times amount, by 2010 editions one annex XD determination of volatile oil method item carapax et plastruw testudinis method behaviour of the Pharmacopoeia of the People's Republic of China
Make, extract with volatile oil extractor；Keeping micro-boiling 5h, to analyzer, oil mass is not further added by, and stops heating.Place sheet
Carve, open analyzer lower end piston, water is slowly released, collect volatile oil；Gained volatile oil is added appropriate anhydrous Na2SO4De-
After water, standby；
(2) take albolene 16.8g, octadecyl alcolol 11.2g and glycerin monostearate 2.8g to be placed in beaker, heat in a water bath
It is made to melt to 70-80 DEG C.By lauryl sodium sulfate 1.4g, glycerine 9.8g, ethyl-para-hydroxybenzoate 0.28g and distilled water
140g puts and is heated to 70-80 DEG C in another beaker and makes it dissolve；Under the conditions of equality of temperature, aqueous phase is slowly added in oil phase, limit
Edged stirring, to condensation, obtains o/w emulsion-type matrix；
(3) take (1) and extract the volatile oil obtained, join in the o/w emulsion-type matrix that (2) prepare, stir, obtain soft
Cream.
Embodiment 4: the external application Chinese medicine of this treatment tinea pedis and manus and tinea of feet and hands is prepared by the raw material of following masses percentage: blue gum
Really 18%, hairyvein agrimony 20%, Elsholtzia densa 18%, pomelo peel 18%, tarragon 11%, chenopodium ambrosiodies 8.2%, cloves 3%, piper cubeba 3%, strong wind
Sub-benevolence 0.8%；
Concrete preparation technology is as follows:
A, medicinal material is cleaned, dry, pulverize after, by following formula feeding: Eucalyptus globules fruits 12.6g, hairyvein agrimony 14g, Elsholtzia densa
12.6g, pomelo peel 12.6g, tarragon 7.7g, chenopodium ambrosiodies 5.74g, cloves 2.1g, piper cubeba 2.1g, chaulmoogra benevolence 0.56g.
B, through following preparation technology:
The pulverizing medicinal materials thing weighed is added CO2The extraction kettle of supercritical extraction unit, in extracting pressure 40MPa, extraction temperature
Under conditions of 45 DEG C after dynamic extraction 2h, receive the volatile oil of extraction from discharging opening, load lucifuge refrigeration in Brown Glass Brown glass bottles and jars only, standby
With.
For proving that the present invention treats the effect of tinea pedis and manus and tinea of feet and hands, sick with pharmacological evaluation, clinical effectiveness and typical case below
Example is illustrated.
Extracorporeal antifungal activity is tested
Prepared by A, bacterium solution
By strain subject (Trichophyton rubrum Trichophyton rubrum and Microsporum gypseum Microsporum
Gypseum) after activating 2 times on SDA, streak inoculation is in SDA plane ware, cultivates 1 week, selects diameter >=1 mm's for 35 DEG C
Bacterium colony 5 dissolves in physiological saline, prepares fungi suspension, and Maxwell is than turbid to 0.5, and making bacterial concentration is (1 ~ 5) × 106 cfu/
mL。
B, experimental technique
Semisolid culturemedium (peptone 1%, glucose 2%, agar 0.3%) is sub-packed in test tube (often pipe 4 mL), at 121 DEG C
Autoclaving 20 min.When sterilising medium is cooled to 40 ~ 50 DEG C, add the made volatile oil of embodiment 1 with sterile working
0.5mL, mixes bevel.Compare with the culture medium being not added with liquid simultaneously.Take tested bacterium solution 1 platinum loop streak inoculation in
On inclined-plane.It is positioned in 28 DEG C of incubators, starts after 3d to observe colony growth state, continuous observation to 18d.To be not added with the sky of bacterium
White comparison is standard, estimates and with following standard recording: bacterium is entirely without growth "-"；Bacterium hypoevolutism, the bacterium colony of formation is less
“+”；Bacterium grows the most vigorous " ++ " (2+)；Bacterium grows more vigorous, but bacterium colony is than normal less " +++ " (3+)；Bacterium blastoprolepsis is prosperous
Contain " ++++" (4+).Each bacterial classification inoculation 3 pipe, if 3 pipe acquired results are identical, then as experimental result, otherwise reforms.
C, experimental result
Test result indicate that, Trichophyton rubrum and Microsporum gypseum are all had stronger by the volatile oil prepared by embodiment 1
Inhibitory action, concrete outcome is shown in Table 1.
Table 1: the embodiment 1 made volatile oil inhibitory action to two kinds of fungies
。
To tinea pedis and manus, the clinical treatment of tinea of feet and hands patient
A, physical data
Selected patient therapy had not used whole body or topical anti-fungal medicine the last week, was respectively provided with local scabies in various degree
Itch.The scurf scraping cutaneous lesion does fungus microscope examination, is all positive.The equal table in sick position is shallow, all finds no and is deeply infecting, local lesion
Differing in size, patient data is shown in Table 2；
Table 2: patient's physical data
；
B, methods for the treatment of
During treatment, no longer oral or other antifungal drugs of external application, methods for the treatment of is shown in Table 3；
Table 3: administrated method and treatment cycle
；
C, Outcome measure
Recovery from illness: skin damages and disappears, the transference cure such as pruitus, the scales of skin that peel off, papule, erythema, blush, sepage, color of the leather is normal, fungi mirror
Inspection feminine gender；Effective: skin damages and alleviates, pruitus or disappearance or alleviate, the scales of skin that peel off, papule, erythema, blush, sepage reduce, fungi mirror
Inspection feminine gender；Invalid: itch, the scales of skin that peel off, papule, erythema, blush, sepage do not subtract or slightly subtract, fungus microscope examination is positive.
D, treatment results
Table 4: the treatment results of each embodiment
；
Any bad reaction is there is not during treatment.
Model case 1 example
Guo, 38 years old, nearly 1 year of existing warts between the both hands palm and the foot sole of the foot, touching difficulty healed, affected part humidity hidrosis, has peculiar smell, and local is acute
Itching, expose flush erosion face at galling epidermis, fungus microscope examination is positive, and is diagnosed as tinea of feet and hands.The volatilization extracted by embodiment 1
Oil is wiped in affected part, each 3 times, each 2mL；After medication 1 week, skin damages and takes a turn for the better.Continuous use was fully recovered after 2 weeks, and fungus microscope examination is the moon
Property.Pay a return visit after 1 year, have no recurrence.
Claims (1)
1. the external application Chinese medicine treating tinea pedis and manus and tinea of feet and hands, it is characterised in that prepared by the raw material of following masses percentage:
Eucalyptus globules fruits 18-26%
Hairyvein agrimony 14-20%
Elsholtzia densa 12-18%
Pomelo peel 12-18%
Tarragon 10-16%
Chenopodium ambrosiodies 7-11%
Cloves 3-5%
Piper cubeba 3-5%
Chaulmoogra benevolence 0.8-1.2%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610167228.9A CN105770099A (en) | 2016-03-23 | 2016-03-23 | Externally applied traditional Chinese medicine for treating tinea corporis and cruris and tinea manus and pedis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610167228.9A CN105770099A (en) | 2016-03-23 | 2016-03-23 | Externally applied traditional Chinese medicine for treating tinea corporis and cruris and tinea manus and pedis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105770099A true CN105770099A (en) | 2016-07-20 |
Family
ID=56391613
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610167228.9A Pending CN105770099A (en) | 2016-03-23 | 2016-03-23 | Externally applied traditional Chinese medicine for treating tinea corporis and cruris and tinea manus and pedis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105770099A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106265861A (en) * | 2016-08-19 | 2017-01-04 | 广州暨南生物医药研究开发基地有限公司 | Antifungal composition containing Chinese mugwort ash and preparation method thereof |
| CN108309630A (en) * | 2018-03-19 | 2018-07-24 | 郑州大学第三附属医院 | A kind of paediatrics patient with severe symptoms bed-sore preventing nursing device |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101537106A (en) * | 2008-03-21 | 2009-09-23 | 北京中泰天和科技有限公司 | Pharmaceutical composition for curing tinea manus and pedis and preparation method thereof |
| CN103566185A (en) * | 2013-11-25 | 2014-02-12 | 蒙小兵 | Traditional Chinese medicine combination for curing tinea of feet and hands and preparation method of same |
-
2016
- 2016-03-23 CN CN201610167228.9A patent/CN105770099A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101537106A (en) * | 2008-03-21 | 2009-09-23 | 北京中泰天和科技有限公司 | Pharmaceutical composition for curing tinea manus and pedis and preparation method thereof |
| CN103566185A (en) * | 2013-11-25 | 2014-02-12 | 蒙小兵 | Traditional Chinese medicine combination for curing tinea of feet and hands and preparation method of same |
Non-Patent Citations (1)
| Title |
|---|
| 刘利萍等: "《实用美容药物常识》", 30 September 2013, 重庆大学出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106265861A (en) * | 2016-08-19 | 2017-01-04 | 广州暨南生物医药研究开发基地有限公司 | Antifungal composition containing Chinese mugwort ash and preparation method thereof |
| CN108309630A (en) * | 2018-03-19 | 2018-07-24 | 郑州大学第三附属医院 | A kind of paediatrics patient with severe symptoms bed-sore preventing nursing device |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US6027728A (en) | Herbal skin regeneration composition and method | |
| CN102091203B (en) | External traditional Chinese medicine preparation for treating chronic wounds and preparation method thereof | |
| CN103041173A (en) | Traditional Chinese medicine external preparation for curing dermatitis and eczema and preparing method thereof | |
| CN103393801B (en) | Traditional Chinese medicine composite extract with effect of removing acnes, and preparation method and application thereof | |
| CN104208245B (en) | Tinea manus and pedis Traditional Chinese medicine medicated bath and preparation method | |
| CN102106941B (en) | Traditional Chinese medicine preparation for treating piles and preparation method of traditional Chinese medicine preparation | |
| CN106804643A (en) | A kind of clinical laboratory Chinese medicine sterilizing thimerosal | |
| Wen et al. | Agrimonia pilosa Ledeb.: a review of its traditional uses, botany, phytochemistry, pharmacology, and toxicology | |
| CN105148288A (en) | Cyclodextrin-and-modified-cyclodextrin-assisted method for extracting effective ingredients of traditional Chinese medicinal materials | |
| CN113876688A (en) | Antibacterial maintenance lotion and preparation method thereof | |
| CN103041247B (en) | Traditional Chinese medicine suppository for curing colpitis and preparation method thereof | |
| CN105770099A (en) | Externally applied traditional Chinese medicine for treating tinea corporis and cruris and tinea manus and pedis | |
| CN108785363A (en) | Application of the yellow wingceltis platymiscium perfume (or spice) material in the drug for preparing treatment microorganism infection | |
| CN108567852A (en) | A kind of pharmaceutical composition of prevention diabetic neuropathy | |
| CN108403932A (en) | A kind of Chinese medicine compound prescription external preparation and its preparation method and application for treating steroid dependent dermatitis | |
| CN101732541B (en) | Chinese medicinal sterilizing liquor for treating skin tinea and eczema and preparation method thereof | |
| CN101371889A (en) | A set of medicament prescription for treating skin tinea and preparation method thereof | |
| CN109528917B (en) | Korean medicinal composition for treating rheumatoid arthritis and preparation method of cream thereof | |
| CN101953951B (en) | Hand and feed health-care and beautifying liquid and preparation method thereof | |
| CN104873714A (en) | Menopausal woman syndrome treatment kidney-tonifying and wind evil dispelling climacteric prescription preparation method | |
| CN104940513A (en) | Pharmaceutical composition for treating menopause syndrome | |
| CN109924553A (en) | A kind of Chinese herbal medicine socks for preventing and treating tinea pedis | |
| CN103585366A (en) | Medicine for treating ischemic hyperlipidemia and preparation method thereof | |
| CN103341044A (en) | Itching-relieving compound preparation and preparation method thereof | |
| CN102357199A (en) | Traditional Chinese medicine for treating manus and tinea pedis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160720 |
|
| RJ01 | Rejection of invention patent application after publication |