CN101537106A - Pharmaceutical composition for curing tinea manus and pedis and preparation method thereof - Google Patents
Pharmaceutical composition for curing tinea manus and pedis and preparation method thereof Download PDFInfo
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- CN101537106A CN101537106A CN 200810102447 CN200810102447A CN101537106A CN 101537106 A CN101537106 A CN 101537106A CN 200810102447 CN200810102447 CN 200810102447 CN 200810102447 A CN200810102447 A CN 200810102447A CN 101537106 A CN101537106 A CN 101537106A
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Abstract
The invention relates to a pharmaceutical composition for curing tinea manus and pedis. The pharmaceutical composition is prepared by the following bulk drugs according to proportioning by weight: 100-200 parts of ginseng, 100-200 parts of broom cypress fruit, 100-200 parts of epimedium, 100-200 parts of Indian bread, 100-200 parts of clove, 100-200 parts of cnidium fruit, 80-160 parts of hairy vein agrimony, 80-160 parts of chaulmoogratree, 80-160 parts of tuber fleeceflower, 80-160 parts of dahurian angelica root, 80-160 parts of Myricaria germanica, 80-160 parts of dried rehmannia root and 30-60 parts of peppermint and processed into clinically accepted tablets, capsules or granules through extracting, refining and other processes.
Description
Technical field:
The invention belongs to technical field of traditional Chinese medicine pharmacy, be specifically related to a kind of drug regimen that is used for the treatment of tinea manus and pedis and preparation method thereof.
Technical background
Tinea manus and pedis is meant the skin lesion that is caused by fungal infection, and certain infectiousness is arranged, and gives others but self infect and infect.Because hand and foot cutin bed thickness, hyperhidrosis and do not have sebum help the growth and breeding of dermatophytes.Therefore, adolescence and adult's tinea manus and pedis sickness rate height.
Tinea manus and pedis is sent out clinically and is antiperspirant scar type, erosive type and squama keratinization type.Antiperspirant scar type is sent out well in an example or both sides and is referred to (toe) most advanced and sophisticated face or palm and vola portion of bending, originally be the full washing basin of heavy wall, be fused into bulla then, bubble liquid is transparent, do not have blush on every side, after scratching often because of the concurrent erysipelas of secondary infection, cellulitis or lymphangitis.That erosive type is sent out well between the 4th toe is moist, dipping turns white or vesicle, does solid back desquamation, and peelling off scurf is rotten to the corn face moistening, flushing, and the patient is odd to itch, easy secondary infection.The squama keratinization type is more common in palm, heel or vola lateral margin, from the beginning of normal no obvious vesicle, is the small pieces squama, and the course of disease is very slow, and Chang Duonian is not healed, and skin follows the string, and that touches is coarse, and chapped skin easily takes place winter.
Showing that according to investigations China tinea manus and pedis pathomycete mainly is trichophyton (73.59%), secondly is acrothesium floccosum (13%) and trichophyton gypseum (11.84%), and other dermatophytosises of minority.Their secretion cutin lyases decompose keratin tissue and draw nourishment from (mainly being carbon and nitrogen) behind the intrusion skin, simultaneously in the breeding down of suitable temperature (about 25 ℃), humidity, acidity (pH5-7).This just tinea manus and pedis send out in summer (temperature, humidity suitable) palm and vola portion (keratin is abundant), and the reason of inflammation not obvious (pathological changes mainly is positioned at horny layer of epidermis) well.
The diagnosis of primary disease is mainly checked according to the fungus of clinical manifestation and affected part skin lesion.Directly the positive expression of microscopy has cutaneous fungal infection, and feminine gender once then can not be got rid of fully.
The right treatment of modern medicine is mainly based on medicine for external use, as whitfield ointment or liniment, and miconazole class cream or compound recipe resorcin preparation etc., existing pressing down killed dermatophytes toothed oak usefulness, has cutin to strip off effect again, recurrence easily after the drug withdrawal.
The traditional Chinese medical science has had understanding to a certain degree for a long time to tinea manus and pedis, as " surgery card control pandect " and " Waike Zhengzong, Orthodox Manual of External Diseases " detailed description is arranged all, and claims that visually the tinea manuum is " fungal infection of hand and foot ", and tinea pedis is " tinea pedis ", " Cipangopaludina chinensis skin ulcer " or " smelly Cipangopaludina chinensis ".
The present invention is directed to a kind of all-natural Chinese herbal and crude drugs preparations that existing in the market medicine is developed the defective spy who treats weak curative effect on the tinea manus and pedis.
Summary of the invention
One of purpose of the present invention provides a kind of drug regimen that is used for the treatment of tinea manus and pedis.
Another object of the present invention provides the preparation method of this Chinese medicine composition.
Chinese medicine of the present invention is made up of active ingredient and/or pharmaceutically acceptable carrier, and wherein said active ingredient is made (part is unit of weight) by following raw materials according:
1. write out a prescription:
Radix Ginseng 100-200 part Fructus Kochiae 100-200 part Herba Epimedii 100-200 part
Rhizoma Smilacis Glabrae 100-200 part Flos Caryophylli 100-200 part Fructus Cnidii 100-200 part
Herba Agrimoniae 80-160 part Semen Hydnocarpi 80-160 part Radix Polygoni Multiflori 80-160 part
Radix Angelicae Dahuricae 80-160 part Cacumen Myricariae Germanicae 80-160 part Radix Rehmanniae 80-160 part
Herba Menthae 30-60 part sodium benzoate 2-4 part
The active component that preferred following raw materials according is made, curative effect is better:
150 parts of 150 parts of Herba Epimedii of 100 parts of Fructus Kochiae of Radix Ginseng
150 parts of 100 parts of Fructus Cnidiis of 150 portions of Flos Caryophyllis of Rhizoma Smilacis Glabrae
120 parts of 80 parts of Radix Polygoni Multiflori of 120 portions of Semen Hydnocarpis of Herba Agrimoniae
120 parts of 80 parts of Radix Rehmanniae of 120 parts of water Cacumen Myricariae Germanicaes of the Radix Angelicae Dahuricae
2 parts of 40 parts of sodium benzoate of Herba Menthae
The active ingredient preparation method of Chinese medicine of the present invention can be that raw material is dry respectively, and levigation mixes.It also can be the conventional method preparation of adopting herbal pharmaceutical.These pharmacy conventional methods can be water extract-alcohol precipitation or ethanol extract from water precipitation, also have other extracting method in addition, specifically " pharmaceutics of Chinese drugs " published referring to Cao Chunlin chief editor's Shanghai science tech publishing house.
The following preparation method preparation of preferred employing:
2. preparation technology
(1) Fructus Kochiae, Fructus Cnidii, the Radix Angelicae Dahuricae add the airtight dipping secondary of 60% ethanol, 24 hours for the first time, 12 hours for the second time, filter merging filtrate;
(2) Radix Ginseng, Herba Epimedii, Rhizoma Smilacis Glabrae, Flos Caryophylli, Herba Agrimoniae, Semen Hydnocarpi, Radix Polygoni Multiflori, Cacumen Myricariae Germanicae, Radix Rehmanniae, Herba Menthae decoct with water three times, and 2 hours for the first time, each 1 hour later on, filter, merging filtrate concentrates, and adds Alumen while hot, stirs and makes dissolving;
(3) above-mentioned two solution are merged, add the 10mol/L sodium hydroxide solution and regulate pH value to 5.0, left standstill 24 hours, filter, filtrate adds sodium benzoate, stirs and makes dissolving, adds water to ormal weight, filters, promptly.
Adopt mutual compatibility of above-mentioned raw material of Chinese medicine and preparation method thereof, clinically be used for the treatment of diseases such as the tinea manuum, tinea pedis, dermatitis, rubella and unknown pruritus.
By the following examples technical scheme of the present invention is described further.
Embodiment 1:
1. write out a prescription
150 parts of 150 parts of Herba Epimedii of 100 parts of Fructus Kochiae of Radix Ginseng
150 parts of 100 parts of Fructus Cnidiis of 150 portions of Flos Caryophyllis of Rhizoma Smilacis Glabrae
120 parts of 80 parts of Radix Polygoni Multiflori of 120 portions of Semen Hydnocarpis of Herba Agrimoniae
120 parts of 80 parts of Radix Rehmanniae of 120 parts of Cacumen Myricariae Germanicaes of the Radix Angelicae Dahuricae
2 parts of 40 parts of sodium benzoate of Herba Menthae
2. preparation technology
(1) Fructus Kochiae, Fructus Cnidii, the Radix Angelicae Dahuricae add the airtight dipping secondary of 60% ethanol, 24 hours for the first time, 12 hours for the second time, filter merging filtrate;
(2) Radix Ginseng, Herba Epimedii, Rhizoma Smilacis Glabrae, Flos Caryophylli, Herba Agrimoniae, Semen Hydnocarpi, Radix Polygoni Multiflori, Cacumen Myricariae Germanicae, Radix Rehmanniae, Herba Menthae decoct with water three times, and 2 hours for the first time, each 1 hour later on, filter, merging filtrate concentrates, and adds Alumen while hot, stirs and makes dissolving;
(3) above-mentioned two solution are merged, add the 10mol/L sodium hydroxide solution and regulate pH value to 5.0, left standstill 24 hours, filter, filtrate adds sodium benzoate, stirs and makes dissolving, adds water to ormal weight, filters, promptly.
Claims (5)
1, a kind of drug regimen that is used for the treatment of tinea manus and pedis is characterized in that being made up of active ingredient and/or pharmaceutically acceptable carrier, and wherein said active ingredient is made by following raw materials according:
Radix Ginseng 100-200 part Fructus Kochiae 100-200 part Herba Epimedii 100-200 part
Rhizoma Smilacis Glabrae 100-200 part Flos Caryophylli 100-200 part Fructus Cnidii 100-200 part
Herba Agrimoniae 80-160 part Semen Hydnocarpi 80-160 part Radix Polygoni Multiflori 80-160 part
Radix Angelicae Dahuricae 80-160 part Cacumen Myricariae Germanicae 80-160 part Radix Rehmanniae 80-160 part
Herba Menthae 30-60 part sodium benzoate 2-4 part
2, a kind of drug regimen that is used for the treatment of tinea manus and pedis according to claim 1 is characterized in that wherein preparing the preferred following raw materials according of described active ingredient:
150 parts of 150 parts of Herba Epimedii of 100 parts of Fructus Kochiae of Radix Ginseng
150 parts of 100 parts of Fructus Cnidiis of 150 portions of Flos Caryophyllis of Rhizoma Smilacis Glabrae
120 parts of 80 parts of Radix Polygoni Multiflori of 120 portions of Semen Hydnocarpis of Herba Agrimoniae
120 parts of 80 parts of Radix Rehmanniae of 120 parts of Cacumen Myricariae Germanicaes of the Radix Angelicae Dahuricae
2 parts of 40 parts of sodium benzoate of Herba Menthae
3, according to the described a kind of drug regimen that is used for the treatment of tinea manus and pedis of claim 1-2, it is characterized in that adopting following method to make:
(1) Fructus Kochiae, Fructus Cnidii, the Radix Angelicae Dahuricae add the airtight dipping secondary of 60% ethanol, 24 hours for the first time, 12 hours for the second time, filter merging filtrate;
(2) Radix Ginseng, Herba Epimedii, Rhizoma Smilacis Glabrae, Flos Caryophylli, Herba Agrimoniae, Semen Hydnocarpi, Radix Polygoni Multiflori, Cacumen Myricariae Germanicae, Radix Rehmanniae, Herba Menthae decoct with water three times, and 2 hours for the first time, each 1 hour later on, filter, merging filtrate concentrates, and adds Alumen while hot, stirs and makes dissolving;
(3) above-mentioned two solution are merged, add the 10mol/L sodium hydroxide solution and regulate pH value to 5.0, left standstill 24 hours, filter, filtrate adds sodium benzoate, stirs and makes dissolving, adds water to ormal weight, filters, promptly.
4, according to any one described a kind of drug regimen that is used for the treatment of tinea manus and pedis among the claim 1-3, it is characterized in that this Chinese medicine composition is an oral formulations.
5, according to the described a kind of drug regimen that is used for the treatment of tinea manus and pedis of claim 3-4, it is characterized in that this Chinese medicine composition can be made into granule, capsule, tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200810102447 CN101537106A (en) | 2008-03-21 | 2008-03-21 | Pharmaceutical composition for curing tinea manus and pedis and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200810102447 CN101537106A (en) | 2008-03-21 | 2008-03-21 | Pharmaceutical composition for curing tinea manus and pedis and preparation method thereof |
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| CN101537106A true CN101537106A (en) | 2009-09-23 |
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| CN 200810102447 Pending CN101537106A (en) | 2008-03-21 | 2008-03-21 | Pharmaceutical composition for curing tinea manus and pedis and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105770099A (en) * | 2016-03-23 | 2016-07-20 | 昆明理工大学 | Externally applied traditional Chinese medicine for treating tinea corporis and cruris and tinea manus and pedis |
-
2008
- 2008-03-21 CN CN 200810102447 patent/CN101537106A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105770099A (en) * | 2016-03-23 | 2016-07-20 | 昆明理工大学 | Externally applied traditional Chinese medicine for treating tinea corporis and cruris and tinea manus and pedis |
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Open date: 20090923 |