CN102370901A - Pharmaceutical composition for treating nephrosis and preparing process thereof - Google Patents
Pharmaceutical composition for treating nephrosis and preparing process thereof Download PDFInfo
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Abstract
The invention relates to a pharmaceutical composition for treating nephrosis and a preparing process thereof, belonging to the field of traditional Chinese medicines. The pharmaceutical composition for treating nephrosis is prepared from the following medicinal materials by weight: 30 to 50 parts of radix astragali, 30 to 50 parts of motherwort, 10 to 30 parts of imperata rhizome, 10 to 30 parts of polygonum aviculare, 10 to 30 parts of dianthus superbus, 10 to 30 parts of herba cephalanoploris, 5 to 15 parts of pyrrosia lingua, 5 to 15 parts of garden burnet root,10 to 30 parts of rhubarb root and 2 to 4 parts of licorice.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition of treating nephropathy and preparation method thereof, belong to the field of Chinese medicines.
Background technology
Nephritis is the glomerule infringement that is caused by multiple reason, can cause the change of glomerular capillary permeability, in various degree albuminuria, hematuria, leukocyturia and cylinderuria occur.The traditional Chinese medical science thinks that this is wet with wind, water, heat, overwork are relevant.
The clear sheet of nephritis uses and acquisition hospital preparation official written reply in Bei Dai River sanatorium of the Beijing Military Area Command from 1979 as hospital preparation, has accumulated certain clinical data between the operating period in hospital.The prescription and the method for preparing of the clear sheet of nephritis are: Radix Astragali 800g, Herba Leonuri 800g, Rhizoma Imperatae 400g 、 Herba Polygoni Avicularis 400g, Herba Dianthi 400g, Herba Cirsii 400g, Folium Pyrrosiae 160g, charred Radix Sanguisorbae 120g, Radix Rumicis 400g, Radix Glycyrrhizae 40g.Get above-mentioned medical material decocte with water 3 times, merge decoction liquor and filter, be concentrated into clear paste, add appropriate amount of starch and granulate, cold drying below 70 ℃ adds magnesium stearate tabletting, sugar coating, promptly gets.
Herba Leonuri in the clear sheet side of nephritis, property is bitter, hot and be slightly cold, and has the merit that inducing diuresis to remove edema, detoxifcation are invigorated blood circulation, and is monarch drug in the side.Rhizoma Imperatae property is sweet, cold, can cooling blood for hemostasis, again can clearing away heat and promoting diuresis, heat conduction is descending, be suitable for that damp-heat in the urinary bladder pents up and the hematuria that causes.We use itself and Herba Leonuri to be monarch drug altogether, the blood of absurd row is belonged in the arteries and veins and fall hematuria.The two share Herba Polygoni Avicularis and Herba Dianthi, is good at clearly damp-heat in lower-JIAO and relieving stranguria by diuresis; Herba Cirsii is kind controls the inferior the puckery swelling pain of urine due to the close-burning heat, stranguria with blood hematuria; Folium Pyrrosiae can be gone up clearing away lung-heat, walk bladder and inducing diuresis for treating stranguria syndrome down; Radix Sanguisorbae is longer than the treatment syndromes of lower-JIAO, in we, takes all burning hot heresies of the medicine heat clearing away part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, cracks part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels congestion; Radix Rumicis can be treated hemoptysis, haematemesis, hematuria, hemorrhoidal bleeding, the metrorrhagia due to the heat in blood, and card such as traumatic hemorrhage.Radix Astragali merit is defended consolidating superficial resistance, inducing diuresis to remove edema, holder skin ulcer granulation promoting in tonifying Qi and lifting yang, benefit.Hematuria has obvious effect to the clear sheet of nephritis due to the reasons such as acute glomerulonephritis, chronic glomerulonephritis, invisible glomerulonephritis, henoch Schonlein purpura nephritis for reducing, and can reduce and alleviate the untoward reaction in the glucocorticoid treatment process.
The traditional handicraft of the clear sheet of nephritis adopts the contract technology of direct preparation of water concentration, has continued to use the technology of Chinese medicine decoction basically, though this technology can keep active ingredient to a certain extent; But its shortcoming also is conspicuous: 1. take the traditional decoction extraction process by water; Follow-up without any refinement treatment, make that the paste-forming rate of product is very high (dried cream yield is more than 30%), patient's dose big (24 of day clothes); Add that chronic nephritis needs long-term prescription, bring great difficulty for taking of patient; 2. adopt coated tablet technology, not only make the great big increase of sheet, and be unfavorable for that diabetics takes, the sickness rate diabetic nephropathy patient that continues to rise has to be limited use especially in recent years; 3. the characteristics of each flavour of a drug during extraction process is not considered to write out a prescription are extracted not exclusively functional component, as according to bibliographical information; The main functional component of Herba Cirsii is that the main functional component of flavone compound, Radix Rumicis is anthraquinone, naphthoquinone and flavone compound in the prescription; These a few compounds alcohol dissolubilities are better, should adopt ethanol extraction in theory, and this process using water extraction; Make the functional component rate of transform lower, extract not exclusively.
The objective of the invention is to characteristics according to each flavour of a drug in the prescription; Take into full account medication crowd's requirement, extraction preparation process reasonable in design is when discarding the dross and selecting the essential; Reach the purpose that keeps even improve drug effect, thereby more help writing out a prescription the performance of drug effect and taking of patient.
Summary of the invention
First technical problem that the present invention will solve provides a kind of pharmaceutical composition of treatment nephropathy evident in efficacy.
Another technical problem that the present invention will solve provides the method for preparing of aforementioned pharmaceutical compositions.
For realizing above-mentioned purpose, the present invention adopts following technical scheme:
A kind of pharmaceutical composition of treating nephropathy, process by the medical material of following portions by weight:
Radix Astragali 30-50 part Herba Leonuri 30-50 part Rhizoma Imperatae 10-30 Fen Herba Polygoni Avicularis 10-30 part Herba Dianthi 10-30 part
Herba Cirsii 10-30 part Folium Pyrrosiae 5-15 part charred Radix Sanguisorbae 5-15 part Radix Rumicis 10-30 part Radix Glycyrrhizae 2-4 part.
Preferred prescription is formed as follows:
20 parts of 20 portions of Herba Dianthis of 40 parts of Herba Leonuris of the Radix Astragali, 40 parts of Rhizoma Imperataes, 20 Fen Herba Polygoni Avicularis
2 parts in 20 portions of Radix Glycyrrhizaes of 6 parts of Radix Rumiciss of 8 parts of charred Radix Sanguisorbae of 20 parts of Folium Pyrrosiaes of Herba Cirsii.
Or with the expression of unit of weight gram, prescription is formed as follows:
Radix Astragali 800g Herba Leonuri 800g Rhizoma Imperatae 400g Herba Polygoni Avicularis 400g Herba Dianthi 400g
Herba Cirsii 400g Folium Pyrrosiae 160g charred Radix Sanguisorbae 120g Radix Rumicis 400g Radix Glycyrrhizae 40g.
In more than forming, the weight of each medicine of distinguishing the flavor of is calculated with crude drug, and said part is weight portion, if per 1 weight portion is unit with the gram, above-mentioned prescription composition can be made into pharmaceutical preparation 200-20000 agent.The said dose of final drug preparation that finger is processed; Agent refers to capsule preparations 200-20000 grain like capsule 200-20000; Tablet 200-20000 agent refers to tablet 200-20000 sheet, is granule 200-20000 gram for granule, and oral liquid is oral liquid 200-20000ml etc.
More than form to be by weight as proportioning; When producing, can increase or reduce according to corresponding proportion; Like large-scale production can be unit with the kilogram, or is unit with the ton, and small-scale production can be unit with the milligram also; Weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.
The ratio of above weight proportion obtains through science screening, for especial patient, and like serious symptom or light disease, fat or modest patient, the proportioning of the amount of can corresponding adjustment forming increases or reduces being no more than 100%, and drug effect is constant.
Raw material of Chinese medicine, especially adjuvant drug in more than forming can be with the suitable Chinese medicine replacement with identical property of medicine with messenger drug, and its drug effect of the Chinese medicine preparation after the replacement is constant.
The pharmaceutical composition of treatment nephropathy of the present invention; The pharmaceutical dosage forms of UD preferably; When processing pharmaceutical preparation, can process any pharmaceutically useful dosage form, these dosage forms are selected from: tablet is like conventional tablet, sugar coated tablet, film coated tablet, enteric coated tablet; Capsule is like hard capsule, soft capsule; And oral liquid, syrup, suck agent, granule, pill, powder, soft extract, suspensoid, solution, injection, suppository, ointment, emplastrum.
The pharmaceutical composition of treatment nephropathy of the present invention, preferably oral formulations form.
The pharmaceutical composition of treatment nephropathy of the present invention becomes pharmaceutically active substance as crude drug through processing and preparing by the Chinese medicine of above-mentioned prescription,, is prepared from the galenic pharmacy routine techniques as effective ingredient with this pharmaceutically active substance.
When being prepared into pharmaceutical preparation, can add some medicine acceptable carriers as required, method for preparing comprises, pharmaceutically active substance is mixed with the medicine acceptable carrier.
The clear preparation of nephritis of the present invention, the preparation of its oral administration can contain excipient commonly used, such as binding agent, filler, diluent, tablet agent, lubricant, disintegrating agent, coloring agent, flavoring agent and wetting agent, can carry out coating to tablet in case of necessity.
The filler that is suitable for comprises cellulose, mannitol, lactose and other similar filler.Suitable disintegrating agent comprises starch, polyvinylpyrrolidone and starch derivatives, for example sodium starch glycollate.Suitable lubricant comprises, for example magnesium stearate.The acceptable wetting agent of appropriate drug comprises sodium lauryl sulphate.
Can fill through mixing, the method that tabletting etc. are commonly used prepares solid oral composition.Mix repeatedly active substance is distributed in those compositionss of a large amount of filleies of whole use.
For drop pill, said pharmaceutical carrier comprises water-soluble base and water-insoluble substrate.For example one or more in polyethylene glycols, poloxamer, polyoxyl stearate, gelatin, stearic acid, glyceryl monostearate, the hydrogenated vegetable wet goods can carry out coating to drop pill in case of necessity.
The form of oral liquid for example can be aqueous or oily suspensions, solution, Emulsion, syrup or elixir, perhaps can be a kind of available water before use or other suitable composite dry products of carrier.This liquid preparation can contain conventional additive; Such as suspending agent; For example sorbitol, syrup, methylcellulose, gelatin, hydroxyethyl-cellulose, carboxymethyl cellulose, aluminium stearate gel or hydrogenation edible fat; Emulsifying agent, for example lecithin, anhydro sorbitol monooleate or arabic gum; Non-aqueous carrier (they can comprise edible oil), for example almond oil, fractionated coconut oil, such as oily ester, propylene glycol or the ethanol of the ester of glycerol; Antiseptic, for example para hydroxybenzene methyl ester or propyl p-hydroxybenzoate or sorbic acid, and if desired, can contain conventional flavouring agent or coloring agent.
For injection, the liquid unit dosage forms of preparation contains active substance of the present invention and sterile carrier.According to carrier and concentration, can this chemical compound be suspended or dissolving.The preparation of solution is normally through being dissolved in active substance in a kind of carrier filter-sterilized before it is packed into a kind of suitable bottle or ampoule, sealing then.For example a kind of local anesthetic of adjuvant, antiseptic and buffer agent also can be dissolved in this carrier.In order to improve its stability, can be after the bottle of packing into that this compositions is freezing, and under vacuum, water is removed.
The pharmaceutical composition of treatment nephropathy of the present invention; When being prepared into medicament, optionally add suitable medicine acceptable carrier; Said medicine acceptable carrier is selected from: mannitol, sorbitol, sodium pyrosulfite, sodium sulfite, sodium thiosulfate, cysteine hydrochloride, TGA, methionine, vitamin C, EDTA disodium, EDTA calcium sodium, the alkali-metal carbonate of monovalence, acetate, phosphate or its aqueous solution, hydrochloric acid, acetic acid, sulphuric acid, phosphoric acid, aminoacid, sodium chloride, potassium chloride, sodium lactate, xylitol, maltose, glucose, fructose, dextran, glycine, starch and derivant thereof, dextrin, sucrose, lactose, mannitol, silicon derivative, cellulose and derivant thereof, alginate, poloxamer, polyoxyl stearate, gelatin, stearic acid, glyceryl monostearate, hydrogenated vegetable oil, polyvinylpyrrolidone, glycerol, soil temperature 80, agar, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, phospholipid material, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate etc.
The pharmaceutical composition of treatment nephropathy of the present invention, when processing medicament, the medicament of UD can contain pharmaceutically active substance 0.1-1000mg of the present invention, and all the other are pharmaceutically acceptable carrier.Pharmaceutically acceptable carrier can be the 0.1-99.9% of total formulation weight amount by weight.
The pharmaceutical composition of treatment nephropathy of the present invention is confirmed usage and dosage according to patient's situation in use, but obeys every day three times, each 1-20 agent, as: 1-20 bag or grain or sheet.
The pharmaceutical composition that the present invention treats nephropathy is to be prepared from through following method, and concrete steps are following:
1. basic technology:
(1) Radix Astragali adds 4-10 times of water gaging and extracts 1-3 time, and each 0.5-3 hour, each time decocting liquid filtered and be concentrated into thick paste or drying, got Radix Astragali extract;
(2) Radix Rumicis and Herba Cirsii add 4-10 and doubly measure concentration of volume percent 30-95% alcohol reflux 1-3 time, and each 0.5-3 hour, each time decocting liquid was concentrated into thick paste or drying, get Radix Rumicis and Herba Cirsii extract;
(3) Herba Leonuri, Rhizoma Imperatae 、 Herba Polygoni Avicularis, Herba Dianthi, Folium Pyrrosiae, charred Radix Sanguisorbae, Radix Glycyrrhizae seven flavor medicine material add 6-12 times of water gaging decoction 1-3 time; Each 0.5-3 hour; It is 1.00-1.20 that decocting liquid is concentrated into relative density, adds the ethanol precipitate with ethanol, and alcohol precipitation concentration is 50-90%; Supernatant reclaims ethanol to thick paste or drying, gets seven flavor extracts;
(4) extract that each step obtains more than, mixing promptly gets pharmaceutically active substance of the present invention.
2. optimised process (preparation technology of zoopery medication, the medicine that in following process parameters range, prepares has identical curative effect):
The medical material of respectively distinguishing the flavor of of recipe quantity extracts as follows:
(1) Radix Astragali adds 6-8 times of water gaging and extracts 2-3 time, and each 1-2 hour, decocting liquid filtered and be concentrated into thick paste or drying, got Radix Astragali extract;
(2) Radix Rumicis, Herba Cirsii add 6-8 and doubly measure alcohol reflux 2-3 time that concentration of volume percent is 70-80%, and each 1-2 hour, decocting liquid filtered and also is concentrated into thick paste or drying, the Radix Rumicis Herba Cirsii extract;
(3) Herba Leonuri, Rhizoma Imperatae 、 Herba Polygoni Avicularis, Herba Dianthi, Folium Pyrrosiae, charred Radix Sanguisorbae, Radix Glycyrrhizae seven flavor medicine material add 8-12 times of water gaging decoction 2-3 time; Each 1-2 hour; It is 1.00-1.20 that decocting liquid is concentrated into relative density, adds the ethanol precipitate with ethanol, and alcohol precipitation concentration is 60-80%; Supernatant reclaims ethanol to thick paste or drying, gets seven flavor extracts.
(4) extract that obtained with last step, mixing promptly gets pharmaceutically active substance of the present invention.
As effective ingredient, be prepared into the clear preparation of nephritis of the present invention with pharmaceutically active substance with the galenic pharmacy routine techniques.
The application of pharmaceutical composition of the present invention in nephropathy class medicines such as preparation treatment chronic glomerulonephritis, acute glomerulonephritis, latent nephritis, henoch Schonlein purpura nephritis, nephrotic syndrome, diabetic nephropathy, lupus property nephropathy, renal failure, IgA nephropathy, non-IgA nephropathy.
The extract that technology of the present invention obtains (pharmaceutically active substance) is compared with the extract that former technology obtains, and has following advantage
Other preferred manufacturing procedure of the present invention in an embodiment.
Further specify the therapeutic effect of pharmaceutical preparation of the present invention through following experiment.
Test the influence of acute renal failure rat urine amount due to a pair of glycerol
[experiment material]
1. laboratory animal: SPF level SD rat, male, body weight 180～220g.Purchase dimension tonneau China company in Beijing.The raising condition: raise in air-conditioned animal housing, temperature is 20 ℃～25 ℃, relative humidity 60%; 5 in every cage, lighting hours 12 hours is added feedstuff at regular time and quantity; Edible Mus special feed (feed corporation,Ltd of Beijing section Australia association produces) is freely drunk water, and changes bedding and padding every day
2. main agents and medicine:
2.1 reagent:
Glycerol: Tianjin chemical reagent company limited; Analytical pure; Lot number: 20070312
Normal saline: the blue pharmaceutcal corporation, Ltd in Tianjin, Tianjin, lot number: 09110904
2.2 medicine:
Receive the reagent thing: the clear A of nephritis (lot number 081101A; Art methods preparation, decocting concentrates for 3 times), the clear B of nephritis (lot number: 081201B; By the embodiment of the invention 4 prepared) sky, Tianjin Shi Li group modern Chinese medicine institute provides
Positive drug: hydrochlorothiazide; Tianjin Lisheng Pharmaceutical Co., Ltd.; Lot number: 0711018
3. experimental apparatus:
Metabolic cage: Suzhou City Feng Laboratory Animal Equipment Co., Ltd
[experimental technique]
1. preliminary election: get 180g-200g SD healthy male rat, adapt to and raised 1 day, fasting can't help water 24 hours before the experiment, after the filling stomach gives the 25ml/kg normal saline, collected 2 hours urine amounts, reached the 40% above person who irritates the stomach amount with voided volume and was selected into experiment.
2. divide into groups:
Get the qualified rat of preliminary election by the body weight random packet, be respectively the blank group, the clear A high and low dose of nephritis group, nephritis clear B high and low dose group and hydrochlorothiazide group (positive controls), 10 every group.Dosage gets according to the clinical administration dosage conversion of clear sheet of nephritis and hydrochlorothiazide tablet; Be respectively the clear A high dose group of nephritis 1000mg crude drug/kg; The clear A low dose group of nephritis 500mg crude drug/kg, the clear B high dose group of nephritis 1000mg crude drug/kg, the clear B low dose group of nephritis 500mg crude drug/kg; Hydrochlorothiazide group 16mg/kg, blank control group is irritated the stomach normal saline.
3. diuresis experiment: each organizes rat intramuscular injection 50% glycerol normal saline solution 10ml/kg modeling respectively, and fasting after the modeling (can't help water) is irritated stomach and given 50ml/kg and comprise and loaded by the normal saline of reagent thing after 24 hours; Compel the rat hypogastric region with hand and make it drain surplus urine, model group gives corresponding normal saline, puts into metabolic cage; One in every cage; Per hour collect urine once, continuous 5 hours, write down per hour urine amount and total volume of urine.
4. statistical method:
When initial data is put in order; With 95% confidence interval definition abnormal data, be about to numerical value and reject above
extraneous data.
Adopt SPSS11.5 software to carry out statistical analysis.Measurement data representes that with
each drug group compares with model group; Adopt one factor analysis of variance, to estimate the effect of medicine.There is the significance meaning P＜0.05 for difference.
[experimental result]
With model group relatively, each group urine amount all increases to some extent, and difference has the significance meaning, the prompting medicine has certain diuresis to rat under the pathological state, but the difference between each administration group does not have statistical significance, promptly the clear A of nephritis, B group effect are suitable.Concrete data see table 1 for details
The clear A of table 1 nephritis, B technology extract are to the influence of acute renal failure rat urine amount due to the glycerol
Compare with model group:
*: P＜0.05;
*: P＜0.01
Test the influence of two pairs of acute glomerulonephritis rat urine protein and hematuria
[experiment material]
1. laboratory animal: SPF level SD rat, male and female half and half, body weight 180～220g.Purchase dimension tonneau China company in Beijing.The raising condition: raise in air-conditioned animal housing, temperature is 20 ℃～25 ℃, relative humidity 60%; 5 in every cage, lighting hours 12 hours is added feedstuff at regular time and quantity; Edible Mus special feed (feed corporation,Ltd of Beijing section Australia association produces) is freely drunk water, and changes bedding and padding every day
2. main agents and medicine:
2.1 reagent:
Normal saline: the blue pharmaceutcal corporation, Ltd in Tianjin, Tianjin, lot number: 09110904
Freund's complete adjuvant: sigma company, CAS:9007-81-2
Urine protein is measured test kit: bio-engineering research institute, lot number: 20090424 are built up in Nanjing
2.2 medicine:
Receive the reagent thing: the clear A of nephritis (lot number 081101A art methods preparation, decocting concentrates for 3 times), the clear B of nephritis (lot number: 081201B is by the embodiment of the invention 4 a prepared) day Shi Li group modern Chinese medicine institute provide
Positive drug: dexamethasone; Tianjin Lisheng Pharmaceutical Co., Ltd.; Lot number: 0812026
3. experimental apparatus:
Metabolic cage: Suzhou City Feng Laboratory Animal Equipment Co., Ltd
Urine analyzer: the Miditron Junior of Roche Holding Ag II
Ultraviolet spectrophotometer: Beijing Rayleigh Analytical Instrument Co.,Ltd, UV-1800
[experimental technique]
1. the preparation of renal cortex homogenate:
Use 10% chloral hydrate (0.35ml/100g) intraperitoneal injection of anesthesia animal; The rat that anesthesia is good is cut off both sides hind leg femoral artery and forelimb tremulous pulse with shears, and fully blood-letting is to make things convenient for subsequent operation.Under aseptic condition, open abdomen; The ligation renal artery, renal veins is cut off to the kidney intubate by the self-ligating place; Washing kidney through intubate repeatedly with the normal saline of pre-cooling is white in color; Take off kidney, bark fetching matter grinds to form homogenate with electronic high-speed homogenization machine in ice bath, is sealed in-70 ℃ of refrigerator and cooled after the packing and freezes for use.
2. the foundation of acute glomerulonephritis model:
Get 25 gram cortex homogenate, add Freund's complete adjuvant to 50ml, place mortar to grind well, slowly add normal saline 100ml, the limit edged grinds, and emulsifying is got final product fully.Get emulsifying agent, select for use and get the kidney rat and carry out lumbar injection with the rat of strain, dosage be each 2ml/ only, per two week injections 1 time are injected 7 times altogether, can make rat nephritis model.
3. divide into groups and administration:
After the last injection, measure the urine protein content of each rat respectively, the standard compliant rat of screening urine protein content goes into group.It is 4 groups that qualified rat is divided into, and (((positive drug, 2mg/kg) group is irritated stomach every day once, successive administration 14 days for 1000mg crude drug/kg) and dexamethasone for 1000mg crude drug/kg), the clear B group of nephritis to be respectively the clear A group of model group, nephritis.
4. draw materials:
Be placed in the metabolic cage in the last administration, collect the twenty-four-hour urine amount,, measure the frequency that hematuria appears in rat urine protein content and each group respectively according to test kit description and instrument operation instruction.And, take by weighing kidney, thymus, spleen and liver in sampling back execution animal, calculate organ coefficient
5. statistical method:
When initial data is put in order; With 95% confidence interval definition abnormal data, be about to numerical value and reject above
extraneous data.
Adopt SPSS11.5 software to carry out statistical analysis.Measurement data representes that with
each drug group compares with model group; Adopt one factor analysis of variance, to estimate the effect of medicine.There is the significance meaning P＜0.05 for difference.
[experimental result]
1. to the influence of urine protein and hematuria: with model group relatively, the clear two groups of technologies of positive drug dexamethasone and nephritis all can reduce the content of rat 24h urine protein, and difference has statistical significance (P＜0.01); Show relatively between two kinds of technology groups that though two groups of technology does not have statistical significance to the difference of improving of urine protein, from data, it is obvious that the clear B group of nephritis reduces effect than the A group.Compare with model group, the clear two groups of technologies of nephritis all can reduce the occurrence rate of hematuria, relatively show between two kinds of technology groups, and it is obvious that the clear B group of nephritis reduces effect than the A group.Concrete data see table 2 for details
The clear different process extract of table 2 nephritis is to the influence of acute glomerulonephritis rat urine protein and hematuria
Compare with model group:
*: P＜0.01
2. to the influence of organ coefficient: with model group relatively, aspect kidney, spleen, thymus and liver, only positive controls demonstrates evident difference; But aspect rat body weight; The rat body weight of positive controls obviously reduces, and difference has statistical significance (P＜0.01), and the result sees table 3
The specific embodiment
Through following specific embodiment only is to explain content of the present invention, is not the further qualification to protection domain of the present invention.
Embodiment 1
Prescription: Radix Astragali 800g Herba Leonuri 800g Rhizoma Imperatae 400g Herba Polygoni Avicularis 400g Herba Dianthi 400g
Herba Cirsii 400g Folium Pyrrosiae 160g charred Radix Sanguisorbae 120g Radix Rumicis 400g Radix Glycyrrhizae 40g
Preparation technology:
(1) Radix Astragali adds 8 times of water gagings and extracts 3 times, and each 1 hour, 3 decocting liquid filtrations also were concentrated into thick paste, and vacuum drying gets Radix Astragali extract;
(2) Radix Rumicis, Herba Cirsii, adding 8 times of amount concentration of volume percent is 60% alcohol reflux 3 times, each 1 hour, merges 3 decocting liquids and be concentrated into thick paste, vacuum drying must the Radix Rumicis Herba Cirsii extract;
(3) Herba Leonuri, Rhizoma Imperatae 、 Herba Polygoni Avicularis, Herba Dianthi, Folium Pyrrosiae, charred Radix Sanguisorbae, Radix Glycyrrhizae seven flavor medicine material add 10 times of water gagings decoctions 2 times, each 2 hours, merge 2 times decocting liquid; Being concentrated into relative density is 1.08 (60 ℃), and adding ethanol, to make determining alcohol be 70%, leaves standstill more than 12 hours; Filter; Filtrate recycling ethanol is to thick paste, and vacuum drying gets seven flavor extracts;
(4) extract that obtained with last step is pulverized, and mixing promptly gets pharmaceutically active substance of the present invention.
As effective ingredient, this effective ingredient mixes with the medicine acceptable carrier, processes pharmaceutical preparation according to the galenic pharmacy routine techniques with pharmaceutically active substance.
Embodiment 2
Prescription: Radix Astragali 800g Herba Leonuri 800g Rhizoma Imperatae 400g Herba Polygoni Avicularis 400g Herba Dianthi 400g
Herba Cirsii 400g Folium Pyrrosiae 160g charred Radix Sanguisorbae 120g Radix Rumicis 400g Radix Glycyrrhizae 40g
Method for preparing:
(1) Radix Astragali adds 10 times of water gagings and extracts 2 times, and each 2 hours, 2 decocting liquid filtrations also were concentrated into thick paste, and microwave drying gets Radix Astragali extract;
(2) Radix Rumicis, Herba Cirsii, adding 10 times of amount concentration of volume percent is 80% alcohol reflux 2 times, each 1.5 hours, merges 2 decocting liquids and be concentrated into thick paste, microwave drying must the Radix Rumicis Herba Cirsii extract;
(3) Herba Leonuri, Rhizoma Imperatae 、 Herba Polygoni Avicularis, Herba Dianthi, Folium Pyrrosiae, charred Radix Sanguisorbae, Radix Glycyrrhizae seven flavor medicine material add 8 times of water gagings decoctions 3 times, each 1 hour, merge 3 times decocting liquid; Being concentrated into relative density is 1.10 (65 ℃), and adding ethanol, to make determining alcohol be 75%, leaves standstill more than 12 hours; Filter; Filtrate recycling ethanol is to thick paste, and microwave drying gets seven flavor extracts;
(4) extract that obtained with last step is pulverized, and mixing promptly gets pharmaceutically active substance of the present invention.
As effective ingredient, this effective ingredient mixes with the medicine acceptable carrier, processes pharmaceutical preparation according to the galenic pharmacy routine techniques with pharmaceutically active substance.
Embodiment 3
Prescription: Radix Astragali 800g Herba Leonuri 800g Rhizoma Imperatae 400g Herba Polygoni Avicularis 400g Herba Dianthi 400g
Herba Cirsii 400g Folium Pyrrosiae 160g charred Radix Sanguisorbae 120g Radix Rumicis 400g Radix Glycyrrhizae 40g
Method for preparing:
(1) Radix Astragali adds 8,6,6 times of water gagings and extracts respectively 3 times, and each 1 hour, 3 times decocting liquid filtered and concentrates, and spray drying gets Radix Astragali extract;
(2) Radix Rumicis, Herba Cirsii, adding 8,6,6 times of amount concentration of volume percent is 70% alcohol reflux 3 times, each 1 hour, merges 3 decocting liquids and concentrate, spray drying must the Radix Rumicis Herba Cirsii extract;
(3) Herba Leonuri, Rhizoma Imperatae 、 Herba Polygoni Avicularis, Herba Dianthi, Folium Pyrrosiae, charred Radix Sanguisorbae, Radix Glycyrrhizae seven flavor medicine material add 6 times of water gagings decoctions 3 times, each 1.5 hours, merge 3 times decocting liquid; Being concentrated into relative density is 1.05 (65 ℃), and adding ethanol, to make determining alcohol be 80%, leaves standstill more than 12 hours; Filter; Filtrate recycling ethanol, spray drying gets seven flavor extracts;
(4) extract that obtained with last step is pulverized, and mixing promptly gets pharmaceutically active substance of the present invention.
As effective ingredient, this effective ingredient mixes with the medicine acceptable carrier, processes pharmaceutical preparation according to the galenic pharmacy routine techniques with pharmaceutically active substance.
Embodiment 4
Prescription: Radix Astragali 800g Herba Leonuri 800g Rhizoma Imperatae 400g Herba Polygoni Avicularis 400g Herba Dianthi 400g
Herba Cirsii 400g Folium Pyrrosiae 160g charred Radix Sanguisorbae 120g Radix Rumicis 400g Radix Glycyrrhizae 40g
Method for preparing:
(1) Radix Astragali adds 8,6,6 times of water gagings and extracts respectively 3 times, and each 1 hour, 3 times decocting liquid filtered and be concentrated into thick paste, gets Radix Astragali extract;
(2) Radix Rumicis, Herba Cirsii, adding 6 times of amount concentration of volume percent is 70% alcohol reflux 3 times, each 1 hour, merges 3 decocting liquids and be concentrated into thick paste, must the Radix Rumicis Herba Cirsii extract;
(3) Herba Leonuri, Rhizoma Imperatae 、 Herba Polygoni Avicularis, Herba Dianthi, Folium Pyrrosiae, charred Radix Sanguisorbae, Radix Glycyrrhizae seven flavor medicine material add 10 times of water gagings decoctions 2 times, each 2 hours, merge 2 times decocting liquid; Being concentrated into relative density is 1.05 (62 ℃); Adding ethanol, to make determining alcohol be 70%, leaves standstill more than 12 hours, filters; Filtrate recycling ethanol gets seven flavor extracts to thick paste;
(4) extract that obtained with last step, mixing promptly gets pharmaceutically active substance of the present invention.
As effective ingredient, this effective ingredient mixes with the medicine acceptable carrier, processes pharmaceutical preparation according to the galenic pharmacy routine techniques with pharmaceutically active substance.
Embodiment 5
Prescription: Radix Astragali 800g Herba Leonuri 800g Rhizoma Imperatae 400g Herba Polygoni Avicularis 400g Herba Dianthi 400g
Herba Cirsii 400g Folium Pyrrosiae 160g charred Radix Sanguisorbae 120g Radix Rumicis 400g Radix Glycyrrhizae 40g
Method for preparing:
(1) Radix Astragali adds 6 times of water gagings and extracts 3 times, and each 2 hours, 3 times decocting liquid filtered and be concentrated into rare cream, gets Radix Astragali extract;
(2) Radix Rumicis, Herba Cirsii, adding 10 times of amount concentration of volume percent is 70% alcohol reflux 2 times, each 2 hours, merges 2 decocting liquids and be concentrated into rare cream, must the Radix Rumicis Herba Cirsii extract;
(3) Herba Leonuri, Rhizoma Imperatae 、 Herba Polygoni Avicularis, Herba Dianthi, Folium Pyrrosiae, charred Radix Sanguisorbae, Radix Glycyrrhizae seven flavor medicine material add 8 times of water gagings decoctions 2 times, each 2 hours, merge 2 times decocting liquid; Being concentrated into relative density is 1.01 (60 ℃); Adding ethanol, to make determining alcohol be 80%, leaves standstill more than 12 hours, filters; Filtrate recycling ethanol to rare cream gets seven flavor extracts;
(4) the extract extractum that obtains of above three steps mixes that to be concentrated into relative density be 1.31 (70 ℃), promptly gets pharmaceutically active substance of the present invention.
As effective ingredient, this effective ingredient mixes with the medicine acceptable carrier, processes pharmaceutical preparation according to the galenic pharmacy routine techniques with pharmaceutically active substance.
Embodiment 6
Prescription: Radix Astragali 800g Herba Leonuri 800g Rhizoma Imperatae 400g Herba Polygoni Avicularis 400g Herba Dianthi 400g
Herba Cirsii 400g Folium Pyrrosiae 160g charred Radix Sanguisorbae 120g Radix Rumicis 400g Radix Glycyrrhizae 40g
Method for preparing:
(1) Radix Astragali adds 8 times of water gagings and extracts 3 times, and each 1 hour, 3 decocting liquid filtrations also were concentrated into thick paste, and drying under reduced pressure gets Radix Astragali extract;
(2) Radix Rumicis, Herba Cirsii, adding 8,6,6 times of amount concentration of volume percent is 70% alcohol reflux 3 times, each 1 hour, merges 3 decocting liquids and be concentrated into thick paste, drying under reduced pressure must the Radix Rumicis Herba Cirsii extract;
(3) Herba Leonuri, Rhizoma Imperatae 、 Herba Polygoni Avicularis, Herba Dianthi, Folium Pyrrosiae, charred Radix Sanguisorbae, Radix Glycyrrhizae seven flavor medicine material add 10 times of water gagings decoctions 2 times, each 1 hour, merge 2 times decocting liquid; Being concentrated into relative density is 1.07 (60 ℃), and adding ethanol, to make determining alcohol be 75%, leaves standstill more than 12 hours; Filter; Filtrate recycling ethanol is to thick paste, and drying under reduced pressure gets seven flavor extracts;
(4) extract that obtained with last step is pulverized, and mixing promptly gets pharmaceutically active substance of the present invention.
As effective ingredient, this effective ingredient mixes with the medicine acceptable carrier, processes pharmaceutical preparation according to the galenic pharmacy routine techniques with pharmaceutically active substance.
Embodiment 7
Prescription: Radix Astragali 600g Herba Leonuri 600g Rhizoma Imperatae 200g Herba Polygoni Avicularis 200g Herba Dianthi 200g
Herba Cirsii 200g Folium Pyrrosiae 100g charred Radix Sanguisorbae 100g Radix Rumicis 300g Radix Glycyrrhizae 40g
Method for preparing:
(1) Radix Astragali adds 8,6,6 times of water gagings and extracts 3 times, and each 1 hour, 3 decocting liquid filtrations also were concentrated into thick paste, and drying under reduced pressure gets Radix Astragali extract;
(2) Radix Rumicis, Herba Cirsii, adding 10 times of amount concentration of volume percent is 80% alcohol reflux 2 times, each 2 hours, merges 2 decocting liquids and be concentrated into thick paste, drying under reduced pressure must the Radix Rumicis Herba Cirsii extract;
(3) Herba Leonuri, Rhizoma Imperatae 、 Herba Polygoni Avicularis, Herba Dianthi, Folium Pyrrosiae, charred Radix Sanguisorbae, Radix Glycyrrhizae seven flavor medicine material add 8,6,6 times of water gagings decoctions 3 times, each 1 hour, merge 3 times decocting liquid; Being concentrated into relative density is 1.02 (60 ℃), and adding ethanol, to make determining alcohol be 80%, leaves standstill more than 12 hours; Filter; Filtrate recycling ethanol is to thick paste, and drying under reduced pressure gets seven flavor extracts;
(4) extract that obtained with last step is pulverized, and mixing promptly gets pharmaceutically active substance of the present invention.
As effective ingredient, this effective ingredient mixes with the medicine acceptable carrier, processes pharmaceutical preparation according to the galenic pharmacy routine techniques with pharmaceutically active substance.
Embodiment 8
Prescription: Radix Astragali 1000g Herba Leonuri 800g Rhizoma Imperatae 600g Herba Polygoni Avicularis 600g Herba Dianthi 600g
Herba Cirsii 600g Folium Pyrrosiae 300g charred Radix Sanguisorbae 300g Radix Rumicis 800g Radix Glycyrrhizae 80g
Method for preparing:
(1) Radix Astragali adds 10,8 times of water gagings and extracts 2 times, and each 1.5 hours, 2 decocting liquid filtrations also were concentrated into thick paste, and spray drying gets Radix Astragali extract;
(2) Radix Rumicis, Herba Cirsii, adding 10,8,6 times of amount concentration of volume percent is 85% alcohol reflux 3 times, each 1 hour, merges 3 decocting liquids and be concentrated into thick paste, spray drying must the Radix Rumicis Herba Cirsii extract;
(3) Herba Leonuri, Rhizoma Imperatae 、 Herba Polygoni Avicularis, Herba Dianthi, Folium Pyrrosiae, charred Radix Sanguisorbae, Radix Glycyrrhizae seven flavor medicine material add 6 times of water gagings decoctions 3 times, each 1.5 hours, merge 3 times decocting liquid; Being concentrated into relative density is 1.07 (64 ℃), and adding ethanol, to make determining alcohol be 80%, leaves standstill more than 12 hours; Filter; Filtrate recycling ethanol is to thick paste, and spray drying gets seven flavor extracts;
(4) extract that obtained with last step, mixing promptly gets pharmaceutically active substance of the present invention.
As effective ingredient, this effective ingredient mixes with the medicine acceptable carrier, processes pharmaceutical preparation according to the galenic pharmacy routine techniques with pharmaceutically active substance.
Embodiment 9
Prescription: Radix Astragali 600g Herba Leonuri 600g Rhizoma Imperatae 400g Herba Polygoni Avicularis 400g Herba Dianthi 400g
Herba Cirsii 400g Folium Pyrrosiae 200g charred Radix Sanguisorbae 200g Radix Rumicis 600g Radix Glycyrrhizae 60g
Method for preparing:
(1) Radix Astragali adds 10,8 times of water gagings and extracts 2 times, and each 2.5 hours, 2 decocting liquid filtrations also were concentrated into thick paste, and microwave drying gets Radix Astragali extract;
(2) Radix Rumicis, Herba Cirsii, adding 6 times of amount concentration of volume percent is 90% alcohol reflux 3 times, each 1 hour, merges 3 decocting liquids and be concentrated into thick paste, microwave drying must the Radix Rumicis Herba Cirsii extract;
(3) Herba Leonuri, Rhizoma Imperatae 、 Herba Polygoni Avicularis, Herba Dianthi, Folium Pyrrosiae, charred Radix Sanguisorbae, Radix Glycyrrhizae seven flavor medicine material add 10 times of water gagings decoctions 3 times, each 2 hours, merge 3 times decocting liquid; Being concentrated into relative density is 1.18 (60 ℃), and adding ethanol, to make determining alcohol be 60%, leaves standstill more than 12 hours; Filter; Filtrate recycling ethanol is to thick paste, and microwave drying gets seven flavor extracts;
(4) extract that obtained with last step is pulverized, and mixing promptly gets pharmaceutically active substance of the present invention.
As effective ingredient, this effective ingredient mixes with the medicine acceptable carrier, processes pharmaceutical preparation according to the galenic pharmacy routine techniques with pharmaceutically active substance.
Embodiment 10, granule
Get any pharmaceutically active substance 100g of embodiment 1-9, add the dextrin of 0.6 times of amount, 0.5% sucrose, 1.5% microcrystalline Cellulose is processed soft material with an amount of dissolve with ethanol, granulates, and 60 ℃ of forced air dryings are granulated, and granulate promptly gets granule.
Embodiment 11, drop pill
Get any pharmaceutically active substance 100g of embodiment 1-9 (adding suitable quantity of water in case of necessity), add the Polyethylene Glycol of 400g, mix homogeneously, fusion, last drop pill machine is processed drop pill.
Embodiment 12, tablet
Get any pharmaceutically active substance 100g of embodiment 1-9, add 5% polyvinylpolypyrrolidone, 0.1% magnesium stearate, 40% microcrystalline Cellulose is granulated, granulate, compacting is wrapped film-coat in flakes, promptly gets.
Embodiment 13, suppository
Get any pharmaceutically active substance 100g of embodiment 1-9; Add behind suitable quantity of water, 1% tween 80,2～3% azones and fused mixed accessories [Macrogol 4000: polyethylene glycol 6000: stearic acid hydrocarbon oxygen (40) ester=3.5: 3.5: 3] mixing; Moulding is processed suppository, promptly gets.
Embodiment 14, capsule
Get any pharmaceutically active substance 100g of embodiment 1-9, add equivalent starch, 0.1% magnesium stearate, an amount of sweeting agent is granulated, and incapsulates, and promptly gets capsule.
Embodiment 15, concentrated pill
Get any pharmaceutically active substance 100g of embodiment 1-9, with microcrystalline Cellulose 50g, PEG6000 8g, mixing adds suitable quantity of water refining medicine, pill, and the bag film-coat promptly gets.
Embodiment 16, oral liquid
Get any pharmaceutically active substance 2g of embodiment 1-9, with syrup 4g, be dissolved in the pure water of 100ml, homogenizing filters, through high-temperature short-time sterilization (135 ℃, 4s).Sterile filling, packing.Make oral liquid.
Claims (10)
1. pharmaceutical composition of treating nephropathy is characterized in that being processed by the medical material of following portions by weight:
Radix Astragali 30-50 part Herba Leonuri 30-50 part Rhizoma Imperatae 10-30 Fen Herba Polygoni Avicularis 10-30 part Herba Dianthi 10-30 part
Herba Cirsii 10-30 part Folium Pyrrosiae 5-15 part charred Radix Sanguisorbae 5-15 part Radix Rumicis 10-30 part Radix Glycyrrhizae 2-4 part.
2. pharmaceutical composition according to claim 1 is characterized in that being processed by the medical material of following portions by weight:
20 parts of 20 portions of Herba Dianthis of 40 parts of Herba Leonuris of the Radix Astragali, 40 parts of Rhizoma Imperataes, 20 Fen Herba Polygoni Avicularis
2 parts in 20 portions of Radix Glycyrrhizaes of 6 parts of Radix Rumiciss of 8 parts of charred Radix Sanguisorbae of 20 parts of Folium Pyrrosiaes of Herba Cirsii.
3. pharmaceutical composition according to claim 1 is characterized in that being processed by the medical material of following portions by weight:
Radix Astragali 30-50 part Herba Leonuri 30-50 part Rhizoma Imperatae 10-30 Fen Herba Polygoni Avicularis 10-30 part Herba Dianthi 10-30 part
Herba Cirsii 10-30 part Folium Pyrrosiae 5-15 part charred Radix Sanguisorbae 5-15 part Radix Rumicis 10-30 part Radix Glycyrrhizae 2-4 part;
Method for preparing is:
(1) Radix Astragali, extracting in water, extracting solution filter to concentrate thick paste or drying, Radix Astragali extract;
(2) Radix Rumicis and Herba Cirsii add the 30-95% alcohol reflux, extracting solution filter to concentrate thick paste or drying, Radix Rumicis and Herba Cirsii extract;
(3) Herba Leonuri, Rhizoma Imperatae 、 Herba Polygoni Avicularis, Herba Dianthi, Folium Pyrrosiae, charred Radix Sanguisorbae, Radix Glycyrrhizae seven flavor medicine material water concentration contract, 50%-80% ethanol precipitate with ethanol, and supernatant concentration gets thick paste or drying, gets seven flavor extracts;
(4) extract that each step obtains more than, mixing promptly gets pharmaceutically active substance, as effective ingredient, is prepared into preparation with the galenic pharmacy routine techniques with pharmaceutically active substance.
4. pharmaceutical composition according to claim 1 is characterized in that containing the pharmacy acceptable auxiliary.
5. pharmaceutical composition according to claim 4; It is characterized in that said pharmacy acceptable auxiliary is selected from: mannitol, sorbitol, sodium pyrosulfite, sodium sulfite, sodium thiosulfate, cysteine hydrochloride, TGA, methionine, vitamin C, EDTA disodium, EDTA calcium sodium, one or more in the alkali-metal carbonate of monovalence, acetate, phosphate or its aqueous solution, hydrochloric acid, acetic acid, sulphuric acid, phosphoric acid, aminoacid, sodium chloride, potassium chloride, sodium lactate, xylitol, maltose, glucose, fructose, dextran, glycine, starch and derivant thereof, dextrin, sucrose, lactose, mannitol, silicon derivative, cellulose and derivant thereof, alginate, poloxamer, polyoxyl stearate, gelatin, stearic acid, glyceryl monostearate, hydrogenated vegetable oil, polyvinylpyrrolidone, glycerol, soil temperature 80, agar, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, phospholipid material, Kaolin, Pulvis Talci, calcium stearate or the magnesium stearate.
6. pharmaceutical composition according to claim 1 is characterized in that said pharmaceutical composition is tablet, capsule, granule, pill, powder, drop pill, syrup, oral liquid, suppository or emplastrum.
7. the described preparation of drug combination method of claim 1 is characterized in that comprising the steps:
(1) Radix Astragali adds 4-10 times of water gaging and extracts 1-3 time, and each 0.5-3 hour, each time decocting liquid filtered and be concentrated into thick paste or drying, got Radix Astragali extract;
(2) Radix Rumicis and Herba Cirsii, adding the concentration of volume percent that 4-10 doubly measures is 30-95% alcohol reflux 1-3 time, each 0.5-3 hour, each time decocting liquid was concentrated into thick paste or drying, must Radix Rumicis and Herba Cirsii extract;
(3) Herba Leonuri, Rhizoma Imperatae 、 Herba Polygoni Avicularis, Herba Dianthi, Folium Pyrrosiae, charred Radix Sanguisorbae, Radix Glycyrrhizae seven flavor medicine material add 6-12 times of water gaging decoction 1-3 time; Each 0.5-3 hour; It is 1.00-1.20 that decocting liquid is concentrated into relative density, adds the ethanol precipitate with ethanol, and alcohol precipitation concentration is 50-90%; Supernatant reclaims ethanol to thick paste or drying, gets seven flavor extracts;
(4) extract that each step obtains more than, mixing promptly gets pharmaceutically active substance, as effective ingredient, is prepared into preparation with the galenic pharmacy routine techniques with pharmaceutically active substance.
8. method for preparing according to claim 7 is characterized in that comprising the steps:
(1) Radix Astragali adds 6-8 times of water gaging and extracts 2-3 time, and each 1-2 hour, decocting liquid filtered and be concentrated into thick paste or drying, got Radix Astragali extract;
(2) Radix Rumicis, Herba Cirsii add 6-8 and doubly measure alcohol reflux 2-3 time that concentration of volume percent is 70-80%, and each 1-2 hour, decocting liquid filtered and also is concentrated into thick paste or drying, the Radix Rumicis Herba Cirsii extract;
(3) Herba Leonuri, Rhizoma Imperatae 、 Herba Polygoni Avicularis, Herba Dianthi, Folium Pyrrosiae, charred Radix Sanguisorbae, Radix Glycyrrhizae seven flavor medicine material add 8-12 times of water gaging decoction 2-3 time; Each 1-2 hour; It is 1.00-1.20 that decocting liquid is concentrated into relative density, adds the ethanol precipitate with ethanol, and alcohol precipitation concentration is 60-80%; Supernatant reclaims ethanol to thick paste or drying, gets seven flavor extracts;
(4) extract that obtained with last step, mixing promptly gets pharmaceutically active substance, as effective ingredient, is prepared into preparation with the galenic pharmacy routine techniques with pharmaceutically active substance.
9. method for preparing according to claim 7 is characterized in that: said preparation is selected from tablet, capsule, granule, pill, powder, drop pill, syrup, oral liquid, suppository or emplastrum.
10. the application of the pharmaceutical composition of claim 1 in nephropathy class medicines such as preparation treatment chronic glomerulonephritis, acute glomerulonephritis, latent nephritis, henoch Schonlein purpura nephritis, nephrotic syndrome, diabetic nephropathy, lupus property nephropathy, renal failure, IgA nephropathy, non-IgA nephropathy.
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| CN2010102618284A CN102370901A (en) | 2010-08-25 | 2010-08-25 | Pharmaceutical composition for treating nephrosis and preparing process thereof |
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| CN2010102618284A CN102370901A (en) | 2010-08-25 | 2010-08-25 | Pharmaceutical composition for treating nephrosis and preparing process thereof |
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| CN103575842A (en) * | 2012-07-24 | 2014-02-12 | 天士力制药集团股份有限公司 | Method for detecting radix astragali main component in nephritis-clearing tablet |
| CN104288606A (en) * | 2014-10-14 | 2015-01-21 | 济南高达信息技术有限公司 | Chinese medicinal tablets for treating acute glomerulonephritis |
| CN105362680A (en) * | 2015-11-14 | 2016-03-02 | 武广丽 | Traditional Chinese medicinal composition for treating latent glomerulonephritis and nursing method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102370903A (en) * | 2010-08-25 | 2012-03-14 | 天津天士力制药股份有限公司 | Pharmaceutical composition for treating nephrosis and preparation method thereof |
| CN102370903B (en) * | 2010-08-25 | 2014-06-11 | 天士力制药集团股份有限公司 | Pharmaceutical composition for treating nephrosis and preparation method thereof |
| CN103575842A (en) * | 2012-07-24 | 2014-02-12 | 天士力制药集团股份有限公司 | Method for detecting radix astragali main component in nephritis-clearing tablet |
| CN103575842B (en) * | 2012-07-24 | 2016-04-20 | 天士力制药集团股份有限公司 | Radix Astragali principal ingredient detection method in the clear sheet of ephritis |
| CN104288606A (en) * | 2014-10-14 | 2015-01-21 | 济南高达信息技术有限公司 | Chinese medicinal tablets for treating acute glomerulonephritis |
| CN105362680A (en) * | 2015-11-14 | 2016-03-02 | 武广丽 | Traditional Chinese medicinal composition for treating latent glomerulonephritis and nursing method |
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Address after: 300410 Tianjin City Hedong District of Beichen Puji Road No. 2 city of the modern Chinese Medicine Applicant after: Tasly Pharmaceutical Group Co., Ltd. Address before: 300410 Tianjin City Hedong District of Beichen Puji Road No. 2 city of the modern Chinese Medicine Applicant before: Tianjin Tianshili Pharmaceutical Co., Ltd. |
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Free format text: CORRECT: APPLICANT; FROM: TIANJIN TIANSHILI PHARMACEUTICAL CO., LTD. TO: TASLY PHARMACEUTICAL GROUPCO., LTD. |
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Application publication date: 20120314 |