CN103055016B - Freeze-dried fresh rehmannia for treating acne - Google Patents
Freeze-dried fresh rehmannia for treating acne Download PDFInfo
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- CN103055016B CN103055016B CN201310008661.4A CN201310008661A CN103055016B CN 103055016 B CN103055016 B CN 103055016B CN 201310008661 A CN201310008661 A CN 201310008661A CN 103055016 B CN103055016 B CN 103055016B
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Abstract
The invention relates to application of freeze-dried fresh rehmannia in preparation of medicines, and in particular relates to application of freeze-dried fresh rehmannia in preparation of a medicine for treating acne. The medicine includes freeze-dried fresh rehmannia or freeze-dried fresh rehmannia extracts. The freeze-dried fresh rehmannia for treating acne disclosed by the invention has the advantages of obvious effect of acne treatment.
Description
Technical field
The present invention relates to medicine, the medicine that particularly prepared by a kind of freeze dried fresh Radix Rehmanniae of Acne treatment, belongs to medical technical field.
Background technology
Radix Rehmanniae is the fresh or dried root of scrophulariaceae rehmannia glutinosa plant Rehmannia glutinosa Li-bosch..Excavate autumn, except removing LU, fibrous root and silt, using fresh herb, practises and claim " Radix Rehmanniae ".It is slowly cured to eighty per cant dry, practise and claim " Radix Rehmanniae ".Get Radix Rehmanniae and stew to wine exhaustion according to stewed with wine method (< < Chinese Pharmacopoeia > > version appendix II D in 2010), take out, when dry in the sun is slightly dry to crust mucus; Or steam to black profit according to steaming method (< < Chinese Pharmacopoeia > > version appendix II D in 2010), take out, shine while doing to approximately eighty per cant, cut sheet or piece, dry, obtain " Radix Rehmanniae Preparata ".The pharmacodynamic feature of these 3 kinds of Radix Rehmanniae is different, and Radix Rehmanniae has the effect of clearing away heat and promoting production of body fluid, removing heat from blood, hemostasis; Radix Rehmanniae has the effect of clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting; Radix Rehmanniae Preparata has the function that nourishing YIN and supplementing blood, beneficial essence are filled out marrow.
The pharmacological research of Radix Rehmanniae has been subject to paying close attention to widely in recent years, and is widely used in clinical.For hemostasis, for diabetes, for cardiovascular and cerebrovascular disease, for hypertension, for nephritis, for dull-witted, for urinary system, for oral ulcer etc.
Acne is a kind of pilosebaceous chronic inflammatory disease dermatoses.Be mainly in youth, mainly betide face and thoracic dorsal etc. and locate, show as acne, pimple, pustule, tuberosity, cyst etc., similar with " rosacea caused by lung-wind " that TCM Document is recorded.As < < Yizong Jinjian surgery heart method > > rosacea caused by lung-wind is recorded: " this card is formed by lung meridian heat in blood; every in face nose, a broken pimple, and shape is considered to be worth doing as broomcorn millet; red complexion swells and ache, and breaks out white lead juice.”。Through long-term research, we find, freeze dried fresh Radix Rehmanniae Acne treatment has good curative effect.
Summary of the invention
The object of this invention is to provide with freeze dried fresh Radix Rehmanniae and prepare the application in Retinoids, Retin-A, Renova, Accutane.
The application of freeze dried fresh Radix Rehmanniae in preparing medicine, feature is that freeze dried fresh Radix Rehmanniae is prepared the application in Retinoids, Retin-A, Renova, Accutane, described medicine contains freeze dried fresh Radix Rehmanniae.
The application of freeze dried fresh Radix Rehmanniae of the present invention in preparing medicine, feature is that described medicine is prepared by single taste freeze dried fresh Radix Rehmanniae.
The application of freeze dried fresh Radix Rehmanniae of the present invention in preparing medicine, feature is the medicine of making, patient's taking dose of a day is equivalent to freeze dried fresh Radix Rehmanniae 3-300g.
The application of freeze dried fresh Radix Rehmanniae of the present invention in preparing medicine, feature is that freeze dried fresh Radix Rehmanniae is directly pulverized, and makes powder and takes.
The application of freeze dried fresh Radix Rehmanniae of the present invention in preparing medicine, feature is that described medicine contains freeze dried fresh Radix Rehmanniae extract.
The application of freeze dried fresh Radix Rehmanniae of the present invention in preparing medicine, feature is that described medicine is prepared by single taste freeze dried fresh Radix Rehmanniae extract.
The application of freeze dried fresh Radix Rehmanniae of the present invention in preparing medicine, feature is according to actual needs, further to add other raw material of Chinese medicine preparations.
The application of freeze dried fresh Radix Rehmanniae of the present invention in preparing medicine, feature is according to actual needs, further to add other raw material of Chinese medicine preparations.
The object of freeze dried fresh Radix Rehmanniae is to solve short, the technical problem such as freight is too high, loss of effective components is larger of Radix Rehmanniae holding time.In the Radix Rehmanniae harvest season, directly with Radix Rehmanniae, preparing medicine of the present invention can reduce costs.Accordingly, the application of freeze dried fresh Radix Rehmanniae of the present invention in preparing medicine, can replace with Radix Rehmanniae at Radix Rehmanniae harvest season medicament freeze-drying Radix Rehmanniae of the present invention, and its consumption is by Radix Rehmanniae conversion.
So far completed the present invention, medicine prepared by freeze dried fresh Radix Rehmanniae of the present invention, Acne treatment is evident in efficacy, has no side effect.The beneficial effect of Acne treatment of the present invention is further set forth in following clinical trial.
1. physical data patients with acne 18 examples, male's 14 examples wherein, women's 4 examples, age reckling 12 years old, the maximum 38 years old, the course of disease is the shortest 1 year, the longest 3 years.Clinical manifestation mainly contains: seborrhea is obvious, the pustule that acne, the little pimple of red inflammatory, hair follicle pustule and papular top form, red tuberosity.
2. Therapeutic Method is got Radix Rehmanniae, cleans roguing, is cut into the Radix Rehmanniae section of length 5cm; By the sabot of Radix Rehmanniae section, loading amount is 4Kg/ ㎡ left and right; Solidification point is controlled at-28 ℃; Reach and control after temperature, open immediately vacuum pump and be evacuated to below drying chamber pressure 50Pa, then start heater switch, promote distillation to rise; The temperature of China should be controlled at below 40 ℃; The temperature of resolution phase should be controlled at below 45 ℃.Make freeze dried fresh Radix Rehmanniae.
Getting freeze dried fresh Radix Rehmanniae is solvent reflux, extract, with methanol, reclaim methanol, add water and stir evenly, n-butanol extraction, butanol solution concentrating under reduced pressure, dissolving adds diethyl ether, active carbon kieselguhr mixed column on insoluble matter, the ethanol of 1-10% of take is eluant, containing the eluent of catalpol, dry, obtain freeze dried fresh Radix Rehmanniae extract.
Get freeze dried fresh Radix Rehmanniae extract, add carboxymethyl starch sodium, gelatinized corn starch is granulated, dry, arranges, and adds Pulvis Talci appropriate, mixes tabletting.Every is equivalent to freeze dried fresh Radix Rehmanniae 20g.Each 5 every day 3 times, 15 days is a course for the treatment of.
3. criterion of therapeutical effect is cured: skin lesion is disappeared, and subjective symptoms disappears; Take a turn for the better: subjective symptoms obviously alleviates, and skin lesion disappears more than 30%; Do not heal: skin lesion and symptom be the unchanged or less than 30% that disappears all.
4. efficacy result is through 2 course of therapy, and wherein healing person's 10 examples, account for 55.5%; Improvement person's 6 examples, account for 33.3%; Person's 2 examples more, account for 11.1%, and total effective rate is 88.9%.
The specific embodiment
embodiment 1
Get freeze dried fresh Radix Rehmanniae, pulverize, obtain powder, be packed as 10g/ bag, Acne treatment, 2 bags of every days, minute 2 clothes.
embodiment 2
Extracting honeysuckle 15kg, Flos Chrysanthemi Indici 15kg, Herba Taraxaci 15kg, Herba Violae 15kg, Radix Salviae Miltiorrhizae 30kg; With water extraction 2 times, add for the first time 8 times of water gagings, extract 1.5 hours, add for the second time 6 times of water gagings and extract 1 hour, merge extractive liquid,, filters, concentrated, dry, add lyophilizing ground bloom 30kg, mix, starch slurry is granulated, dry, granulate, add Pulvis Talci appropriate, tabletting, Acne treatment, 12 of every days (containing lyophilizing ground bloom 3g), minute 3 clothes, 1 month were 1 course for the treatment of.
embodiment 3
Get Radix Rehmanniae, clean roguing, be cut into the Radix Rehmanniae section of length 5cm; By the sabot of Radix Rehmanniae section, loading amount is 4Kg/ ㎡ left and right; Solidification point is controlled at-28 ℃; Reach and control after temperature, open immediately vacuum pump and be evacuated to below drying chamber pressure 50Pa, then start heater switch, promote distillation to rise; The temperature of China should be controlled at below 40 ℃; The temperature of resolution phase should be controlled at below 45 ℃.Make freeze dried fresh Radix Rehmanniae.
Getting freeze dried fresh Radix Rehmanniae is solvent reflux, extract, with methanol, reclaim methanol, add water and stir evenly, n-butanol extraction, butanol solution concentrating under reduced pressure, dissolving adds diethyl ether, active carbon kieselguhr mixed column on insoluble matter, the ethanol of 1-10% of take is eluant, containing the eluent of catalpol, dry, obtain freeze dried fresh Radix Rehmanniae extract.
Extracting honeysuckle 15kg, Flos Chrysanthemi Indici 15kg, Radix Salviae Miltiorrhizae 30kg, Herba Artemisiae Scopariae 15kg, Bulbus Fritillariae Thunbergii 10kg, Concha Ostreae 30kg; With water extraction 2 times, add for the first time 10 times of water gagings, extract 2 hours, add for the second time 8 times of water gagings and extract 1 hour, merge extractive liquid,, filters, concentrated, dry, obtains Chinese medicine extract.
Get freeze dried fresh Radix Rehmanniae extract, Chinese medicine extract, add carboxymethyl starch sodium, gelatinized corn starch is granulated, dry, arranges, and adds Pulvis Talci appropriate, mixes tabletting.Every is equivalent to freeze dried fresh Radix Rehmanniae 10g.The patient who is used for the treatment of acne, each 5, every day 3 times.
embodiment 4
Extracting honeysuckle 15kg, Herba Taraxaci 15kg, Radix Salviae Miltiorrhizae 30kg, Fructus Crataegi 30kg, Rhizoma Atractylodis Macrocephalae 10kg, Semen Coicis 30kg, Radix Glycyrrhizae 3kg; With water extraction 2 times, add for the first time 12 times of water gagings, extract 1.5 hours, add for the second time 8 times of water gagings and extract 1 hour, merge extractive liquid,, filters, concentrated, dry, obtains medicinal substances extract.
Get freeze dried fresh Radix Rehmanniae 12kg, with ethanol percolate extraction, extracting solution reclaims ethanol, dry, obtains freeze dried fresh Radix Rehmanniae extract.
Get medicinal substances extract, freeze dried fresh Radix Rehmanniae extract, mix, add dextrin, granulate, dry, granulate, obtains granule, is used for the treatment of acne, and every day, 30g(was equivalent to containing lyophilizing Radix Rehmanniae 12g), minute 2 clothes.
embodiment 5
Extracting honeysuckle 15kg, Herba Taraxaci 15kg, Radix Salviae Miltiorrhizae 30kg, Fructus Crataegi 30kg, Rhizoma Atractylodis Macrocephalae 10kg, Semen Coicis 30kg, Radix Glycyrrhizae 3kg; With water extraction 2 times, add for the first time 12 times of water gagings, extract 1.5 hours, add for the second time 8 times of water gagings and extract 1 hour, merge extractive liquid,, filters, concentrated, dry, obtains medicinal substances extract.
Get Radix Rehmanniae 150kg, with ethanol percolate extraction, extracting solution reclaims ethanol, dry, obtains Radix Rehmanniae extract.
Get medicinal substances extract, Radix Rehmanniae extract, mix, add dextrin, granulate, dry, granulate, obtains granule, is used for the treatment of acne, and every day, 30g(was equivalent to containing lyophilizing Radix Rehmanniae 12g), minute 2 clothes.
Claims (1)
1. the preparation method of the medicine of an Acne treatment; be characterised in that by following steps and prepare: getting freeze dried fresh Radix Rehmanniae is solvent reflux, extract, with methanol, reclaim methanol, add water and stir evenly; n-butanol extraction; butanol solution concentrating under reduced pressure, the dissolving that adds diethyl ether, active carbon kieselguhr mixed column on insoluble matter; the ethanol of 1-10% of take is eluant; containing the eluent of catalpol, dry, obtain freeze dried fresh Radix Rehmanniae extract; Get freeze dried fresh Radix Rehmanniae extract, add carboxymethyl starch sodium, gelatinized corn starch is granulated, and dry, granulate, adds Pulvis Talci appropriate, mixes tabletting;
Wherein, the method for freeze dried fresh Radix Rehmanniae is: get Radix Rehmanniae, clean roguing, be cut into the Radix Rehmanniae section of length 5cm; By the sabot of Radix Rehmanniae section, loading amount is 4Kg/ ㎡; Solidification point is controlled at-28 ℃; Reach and control after temperature, open immediately vacuum pump and be evacuated to below drying chamber pressure 50Pa, then start heater switch, promote distillation; The temperature of distillation should be controlled at below 40 ℃; The temperature of resolution phase should be controlled at below 45 ℃.
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Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103977041A (en) * | 2014-05-15 | 2014-08-13 | 济南康众医药科技开发有限公司 | Drying method of ganoderma applanatum pat |
| CN104147227B (en) * | 2014-08-25 | 2016-12-07 | 济南康众医药科技开发有限公司 | A kind of lyophilizing Radix Rehmanniae treating cerebral thrombosis |
| CN104154721A (en) * | 2014-08-25 | 2014-11-19 | 济南康众医药科技开发有限公司 | Rehmannia freeze-drying method |
| CN104147222A (en) * | 2014-08-25 | 2014-11-19 | 济南康众医药科技开发有限公司 | Preparation of raw rehmannia glutinosa and prepared rehmannia glutinosa through freezing method |
| CN104147225A (en) * | 2014-08-25 | 2014-11-19 | 济南康众医药科技开发有限公司 | Freeze-dried rehmannia glutinosa used as high-bioavailability decocting pieces |
| CN104147221B (en) * | 2014-08-25 | 2017-02-01 | 济南康众医药科技开发有限公司 | Freeze-drying method of rehamnnia glutinosa |
| CN104208171B (en) * | 2014-09-29 | 2016-10-05 | 刘昆 | A kind of Chinese medicine composition treating acne |
| CN105147798A (en) * | 2015-09-29 | 2015-12-16 | 李凤 | Traditional Chinese medicine composition for treating acnes |
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| CN1253182C (en) * | 2003-04-23 | 2006-04-26 | 孙金生 | Chinese materia medica preparation for curing acne |
| CN101032593A (en) * | 2007-04-16 | 2007-09-12 | 北京艺信堂医药研究所 | Acne-treating Chinese medicine preparation |
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| 徐泽等.地黄.《中国美容之秘》.三秦出版社,1990,(第1版),第41页. * |
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Owner name: JI NAN SUNNYPHARMACY CO., LTD. Free format text: FORMER OWNER: JINAN KANGZHONG MEDICIN SCIENCE + TECHNOLOGY CO., LTD. Effective date: 20150429 |
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Effective date of registration: 20150429 Address after: 250200 Shandong Province, Zhangqiu City Industrial Economic Development Zone Mingshui Road Northwest Section Patentee after: Jinan Sunnypharmacy Co., Ltd. Address before: Lixia District Hospital in Shandong province Ji'nan City Road 250014 No. 19 No. 4 West of Shandong Academy of Sciences Patentee before: Jinan Kangzhong Medicin Science & Technology Co., Ltd. |