CN104147222A - Preparation of raw rehmannia glutinosa and prepared rehmannia glutinosa through freezing method - Google Patents
Preparation of raw rehmannia glutinosa and prepared rehmannia glutinosa through freezing method Download PDFInfo
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- CN104147222A CN104147222A CN201410418820.2A CN201410418820A CN104147222A CN 104147222 A CN104147222 A CN 104147222A CN 201410418820 A CN201410418820 A CN 201410418820A CN 104147222 A CN104147222 A CN 104147222A
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Abstract
The invention relates to preparation of rehmannia glutinosa decocting pieces through a freezing technology. A preparing method of raw rehmannia glutinosa includes following steps: freezing fresh rehmannia glutinosa to under -10 DEG C, increasing the temperature to room temperature and slowly baking the fresh rehmannia glutinosa until the fresh rehmannia glutinosa is 80% dried. A preparing method of prepared rehmannia glutinosa includes following steps: freezing fresh rehmannia glutinosa to under -10 DEG C, increasing the temperature to room temperature, slowly baking the fresh rehmannia glutinosa until the fresh rehmannia glutinosa is 80% dried, and preparing the prepared rehmannia glutinosa according to "Chinese pharmacopoeia". The method is short in processing period and is high in efficiency. The raw rehmannia glutinosa and the prepared rehmannia glutinosa are in conformity with raw rehmannia glutinosa and prepared rehmannia glutinosa which are prepared through a conventional method in functions and major functions, but are better in curative effects.
Description
Invention field
The present invention relates to medicine method for making, be specifically related to prepare Radix Rehmanniae and Radix Rehmanniae Preparata by freezing method, belong to medical technical field.
Background technology
Medicinal material processing refers to processs processing by medical material by clean system, cutting, big gun, makes the decoction pieces of certain specification, to adapt to the needs of medical requirement and allotment, preparation, guarantees drug safety and effective.Chinese crude drug is processed through certain process of preparing Chinese medicine, can reach make that medical material is pure, taste masking, reduction toxicity and dry and stay-in-grade object.Concoct to also have medicament curative effect enhancement, change pharmaceutical properties, be convenient to adjust the effects such as preparation.Chinese medicine processing method is divided into the system of repairing, water system, fire preparing, preparing with water and fire together, the large class of other method for makings 5 conventionally.
Radix Rehmanniae is the fresh or dried root of scrophulariaceae rehmannia glutinosa plant.Excavate autumn, except removing LU, fibrous root and silt, using fresh herb, practises and claim " Radix Rehmanniae ".It is slowly cured to eighty per cant dry, practise and claim " Radix Rehmanniae ".Get Radix Rehmanniae and stew to wine exhaustion according to stewed with wine method (< < Chinese Pharmacopoeia > > version appendix II D in 2010), take out, when dry in the sun is slightly dry to crust mucus; Or steam to black profit according to steaming method (< < Chinese Pharmacopoeia > > version appendix II D in 2010), take out, shine while doing to approximately eighty per cant, cut sheet or piece, dry, obtain " Radix Rehmanniae Preparata ".The pharmacodynamic feature of these 3 kinds of Radix Rehmanniae is different, and Radix Rehmanniae has the effect of clearing away heat and promoting production of body fluid, removing heat from blood, hemostasis; Radix Rehmanniae has the effect of clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting; Radix Rehmanniae Preparata has the function that nourishing YIN and supplementing blood, beneficial essence are filled out marrow.
Traditional method prepares that the radix rehmanniae cycle is long, and efficiency is low, and its effective ingredient stripping is slow, is necessary to improve.
Summary of the invention
The preparation method that the object of this invention is to provide a kind of new Radix Rehmanniae and Radix Rehmanniae Preparata, its time is short, and efficiency is high, better efficacy.
The present invention is achieved in that
By freezing method, prepare Radix Rehmanniae and Radix Rehmanniae Preparata, it is characterized in that the method for making of Radix Rehmanniae is: Radix Rehmanniae is refrigerated to below-10 ℃, rises to room temperature, take out and slowly to cure to eighty per cant dry, obtain Radix Rehmanniae.
Of the present inventionly by freezing method, prepare Radix Rehmanniae and Radix Rehmanniae Preparata, the method for making that it is characterized in that Radix Rehmanniae Preparata is: Radix Rehmanniae is refrigerated to below-10 ℃, rise to room temperature, take out and slowly to cure to eighty per cant dry, according to < < Chinese Pharmacopoeia > > version stewed with wine method in 2010 or steaming method, prepare Radix Rehmanniae Preparata.
Substantive progressive being of the present invention, the process-cycle is short, and efficiency is high; Effective ingredient and composition form basically identical; Effective ingredient dissolution rate is high, and stripping is fast.And then known, Radix Rehmanniae prepared by the inventive method and Radix Rehmanniae Preparata, Radix Rehmanniae and Radix Rehmanniae Preparata that pharmacodynamic feature is prepared with traditional method are consistent, and good effect.
Below by test example, usefulness of the present invention is described.
One, processing method:
Radix Rehmanniae picked up from Distributions in Liaocheng of Shandong Province in October, 2012, and the Radix Rehmanniae of being gathered in same plot is simultaneously processed respectively by following 5 kinds of methods:
1) Radix Rehmanniae: new Radix Rehmanniae soil buries, plastic bag sealing moisturizing;
2) traditional law system Radix Rehmanniae: get Radix Rehmanniae, slowly cure to eighty per cant dry;
3) the inventive method Radix Rehmanniae processed: Radix Rehmanniae is refrigerated to below-10 ℃, rises to room temperature, takes out, and slowly cures to eighty per cant dry;
4) traditional method Radix Rehmanniae Preparata decoction pieces processed: get the standby Radix Rehmanniae of traditional law system, according to < < Chinese Pharmacopoeia > > version in 2010, steam method, steam to black profit, take out, when dry in the sun is slightly dry to crust mucus, cut sheet or piece, dry, obtain Radix Rehmanniae Preparata.
5) Radix Rehmanniae of the inventive method Radix Rehmanniae Preparata decoction pieces processed: get 3) preparing, according to < < Chinese Pharmacopoeia > > version in 2010, steam method, steam to black profit, take out, when dry in the sun is slightly dry to crust mucus, cut sheet or piece, dry, obtain Radix Rehmanniae Preparata.
Two, different processing methods period ratio
The yellow cycle of table 1 different processing methods (hour, %)
| Sequence number | Method for making | Time | Water content |
| 1 | Traditional law system Radix Rehmanniae | 72 | 13.5 |
| 2 | The inventive method Radix Rehmanniae processed | 35 | 9.7 |
| 3 | Traditional method Radix Rehmanniae Preparata processed | 8 | 14.4 |
| 4 | The inventive method Radix Rehmanniae Preparata processed | 4 | 13.3 |
As can be seen from Table 1, the inventive method is prepared Radix Rehmanniae and Radix Rehmanniae Preparata, and the process-cycle obviously shortens, and water content is also lower than traditional diamond-making technique.And then known, the inventive method prepares Radix Rehmanniae and Radix Rehmanniae Preparata efficiency is high.
Three, catalpol content comparison in different processing methods Radix Rehmanniae drink
According to method under Chinese Pharmacopoeia 2010 editions () Radix Rehmanniae item, measure.
1, reagent, instrument: high performance liquid chromatograph (Japanese Shimadzu LC-3A).Catalpol is purchased from Nat'l Pharmaceutical & Biological Products Control Institute.
2 condition determinations: measure according to high performance liquid chromatography (appendix VI D of Chinese Pharmacopoeia).Chromatographic condition and system suitability, take octadecylsilane chemically bonded silica as filler; Acetonitrile-0.1% phosphoric acid solution (1: 99) of take is mobile phase; Detection wavelength is 210nm.Number of theoretical plate calculates and should be not less than 5000 by tanshinone IIA peak.
The preparation of reference substance solution: it is appropriate that precision takes catalpol reference substance, adds mobile phase and makes every 1m1 containing the solution of 10 μ g, obtains.
The preparation of need testing solution: sample thief is cut into the fritter of about 5mm, after 24 hours, wears into the about 0.4g of coarse powder through 80 ℃ of drying under reduced pressure, accurately weighed, put in tool plug conical flask, precision adds methanol 25ml, weighed weight, heating and refluxing extraction 1.5 hours, let cool, more weighed weight, with methanol, supply the weight of less loss, shake up, filter.Precision measures subsequent filtrate 10ml, is concentrated near doing, and residue dissolves by mobile phase, is transferred in 10ml measuring bottle, and is diluted to scale by mobile phase, shakes up, and mistake, gets subsequent filtrate, obtains.
Algoscopy: precision is drawn reference substance solution and each 10 μ 1 of need testing solution respectively, and injection liquid chromatography, measures, and obtains.In dry product, measurement result is in Table 2.
In table 2 different processing methods radix rehmanniae, catalpol content (%) relatively
| Sequence number | Method for making | Content |
| 1 | Traditional law system Radix Rehmanniae | 0.2117 |
| 2 | The inventive method Radix Rehmanniae processed | 0.2116 |
| 3 | Traditional method Radix Rehmanniae Preparata processed | 0.0894 |
| 4 | The inventive method Radix Rehmanniae Preparata processed | 0.0890 |
As can be seen from Table 2, Radix Rehmanniae and Radix Rehmanniae Preparata decoction pieces that in the Radix Rehmanniae that prepared by the inventive method and Radix Rehmanniae Preparata decoction pieces prepared by catalpol content and traditional method are basically identical.And then known its function cures mainly basically identical.
Four, total polysaccharides content comparison in different processing methods Radix Rehmanniae and Radix Rehmanniae Preparata
Take each 0.5kg of sample, use respectively 95% ethanol percolation, the sample after alcohol extraction, 8 times of amounts are distilled decocting in water 3 times, merge extractive liquid,, is concentrated into 500ml, adds ethanol to being 90% containing alcohol amount, and placement is spent the night, sucking filtration, with ethanol, third, ether washing, waves loose reagent to dry successively, obtains total polysaccharides.In dry product, measurement result is in Table 3.
Table 3 different processing methods adds total polysaccharides content (%) in yellow decoction pieces and compares
| Sequence number | Method for making | Content |
| 1 | Radix Rehmanniae | 5.26 |
| 2 | Traditional law system Radix Rehmanniae | 18.9747 |
| 3 | The inventive method Radix Rehmanniae processed | 18.9752 |
| 4 | Traditional method Radix Rehmanniae Preparata processed | 27.5321 |
| 5 | The inventive method Radix Rehmanniae Preparata processed | 27.5339 |
As can be seen from Table 3, it is basically identical that the inventive method is prepared Radix Rehmanniae and Radix Rehmanniae Preparata decoction pieces that in Radix Rehmanniae and Radix Rehmanniae Preparata medicine prepared by total polysaccharides content and traditional method.And then known its function cures mainly basically identical.
Five, different processing methods extract content comparison
According to < < Chinese Pharmacopoeia > >, within 2010, under version Radix Rehmanniae item, measure extract content.In dry product, water-soluble extractives measurement result is in Table 4.
Table 4 with processing method extract content (%) relatively
| Sequence number | Method for making | Content |
| 1 | Traditional law system Radix Rehmanniae | 66.46 |
| 2 | The inventive method Radix Rehmanniae processed | 66.49 |
| 3 | Traditional method Radix Rehmanniae Preparata processed | 70.21 |
| 4 | The inventive method Radix Rehmanniae Preparata processed | 70.21 |
Radix Rehmanniae and Radix Rehmanniae Preparata prepared by the Radix Rehmanniae that as can be seen from Table 4, prepared by the inventive method and Radix Rehmanniae Preparata decoction pieces extract content and traditional method are basically identical.
6, content of reducing sugar comparison
The preparation of sample: get the fritter that each sample is cut into about 5mm, get 5g, accurately weighed, respectively add 50ml swallow to heat up in a steamer water boil 20min, extract 2 times, merge solution, be settled to 100ml, be extracting solution.
The mensuration of sample: adopt Fehlings reagent.Getting said extracted solution 20ml puts in 100ml volumetric flask, drip acetic acid zinc solution and 10.6% ferrous each l0ml of atmosphere potassium solution, then adding distil water standardize solution, place 1 hour, make it precipitation completely, filter, filtrate is placed in titration bottle, the fehling reagent of titrimetric standard, the volume that consumed per sample, calculates the smart content of reduction.In dry product, content of reducing sugar the results are shown in Table 5.
In the different processing sides of table 5 decoction pieces, content of reducing sugar (%) relatively
| Sequence number | Method for making | Content |
| 1 | Traditional law system Radix Rehmanniae | 13.84 |
| 2 | The inventive method Radix Rehmanniae processed | 13.86 |
| 3 | Traditional method Radix Rehmanniae Preparata processed | 44.51 |
| 4 | The inventive method Radix Rehmanniae Preparata processed | 44.53 |
As can be seen from Table 5, Radix Rehmanniae and Radix Rehmanniae Preparata decoction pieces that in the Radix Rehmanniae that prepared by the inventive method and Radix Rehmanniae Preparata decoction pieces prepared by content of reducing sugar and traditional method are basically identical.
Six, different processing methods radix rehmanniae extractum leaching rate comparison
This test adopts the solution (sodium chloride 2.0g, adds water and dissolve in right amount, adds hydrochloric acid 7ml, is diluted with water to 1000 ml, obtains) of pH1.2 to simulate normal person's simulated gastric fluid.Because food is 90-120min at the emptying time of people's gastric, therefore this test is at each point in time sampling of 5-120min.
Sample thief, pulverize, get respectively 6 parts, every part of 10g, according to < < Chinese Pharmacopoeia > > Their Dissolution Test in vitro method, measure, the solution 600ml of pH1.2 of take is solvent, rotating speed is 50 r/ min, through 5,10,15,30,45,60,90, during 120 min, get respectively solution 10ml, dry, weigh (W1), and immediately in process container, supplement dissolution medium, by sample 10g(W) calculate sample at the stripping quantity of different time.Computing formula dissolution rate=W1/W * 100/100.The results are shown in Table 6.
Table 6 different processing methods radix rehmanniae dissolution rate comparison (%, n=6)
This result of the test shows each time point at 5-120min, and Radix Rehmanniae of the present invention and Radix Rehmanniae Preparata decoction pieces dissolution rate are apparently higher than Radix Rehmanniae and the Radix Rehmanniae Preparata decoction pieces of traditional law system, and then known better efficacy.
The Radix Rehmanniae that different processing methods is produced, also can there is corresponding change in its nature and flavor, effect.Radix Rehmanniae is cold in nature, sweet-bitter flavor, take clearing away heat and promoting production of body fluid, cooling blood for hemostasis as main.Radix Rehmanniae is name Radix Rehmanniae after processing is dried, and its cold in nature, sweet in the mouth, take clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting as main.Radix Rehmanniae is name Radix Rehmanniae Preparata after steaming, and its property is by the cold temperature that turns, and its taste turns sweet by hardship, and its effect is by turning clearly benefit, take nourishing YIN and supplementing blood, beneficial essence to fill out marrow as main.Chinese medicine is brought into play the complex that bioactive material base is comprised of effective ingredient and multicomponent, " Radix Rehmanniae ", " Radix Rehmanniae ", " Radix Rehmanniae Preparata ", the pharmacodynamic feature of 3 kinds of Radix Rehmanniae is different, to be formed due to difference by effective ingredient and composition, more than experiment shows, the Radix Rehmanniae that the present invention makes and Radix Rehmanniae Preparata decoction pieces and traditional method make Radix Rehmanniae and Radix Rehmanniae Preparata decoction pieces, and in product, the effective ingredient such as catalpol, total polysaccharides, extractum, content of reducing sugar and composition form basically identical.And then known, Radix Rehmanniae prepared by the inventive method and Radix Rehmanniae Preparata, it is consistent that function cures mainly Radix Rehmanniae and the Radix Rehmanniae Preparata prepared with traditional method.But the process-cycle is short, the easy stripping of effective ingredient.
The specific embodiment
embodiment 1
By Radix Rehmanniae 10kg, be placed in fridge, be refrigerated to-10 ℃, naturally rise to room temperature, take out, slowly cure to eighty per cant dry, obtain Radix Rehmanniae.
embodiment 2
By Radix Rehmanniae 100kg, be placed in fridge, be refrigerated to-15 ℃, rise to room temperature, take out, slowly cure to eighty per cant dry, obtain Radix Rehmanniae.
embodiment 3
By Radix Rehmanniae 200kg, be placed in fridge, be refrigerated to below-20 ℃, rise to room temperature, take out, slowly cure to eighty per cant dry, obtain Radix Rehmanniae.
embodiment 4
By Radix Rehmanniae 50kg, be placed in fridge, be refrigerated to-10 ℃, rise to room temperature, take out and slowly to cure to eighty per cant dry, take out, according to < < Chinese Pharmacopoeia > > version stewed with wine method in 2010, stew to wine and exhaust, when taking-up dry in the sun is slightly dry to crust mucus, cut sheet or piece, dry, obtain Radix Rehmanniae Preparata.
embodiment 5
Get the Radix Rehmanniae 50kg of embodiment 3 preparations, add yellow wine 20 kg, according to < < Chinese Pharmacopoeia > > version stewed with wine method in 2010, stew to wine and exhaust, take out, when dry in the sun is slightly dry to crust mucus, cut sheet or piece, dry, obtain Radix Rehmanniae Preparata.
embodiment 6
Get freeze dried fresh Radix Rehmanniae 60kg, add yellow wine 30 kg, according to < < Chinese Pharmacopoeia > > version stewed with wine method in 2010, stew to wine and exhaust, take out, when dry in the sun is slightly dry to crust mucus, cut sheet or piece, dry, obtain Radix Rehmanniae Preparata.
embodiment 7
By Radix Rehmanniae 70kg, be placed in fridge, be refrigerated to-10 ℃, rise to room temperature, take out, slowly cure to eighty per cant dry, take out, according to < < Chinese Pharmacopoeia > > version in 2010, steam method, steam to black profit, take out, when dry in the sun is slightly dry to crust mucus, cut sheet or piece, dry, obtain Radix Rehmanniae Preparata.
embodiment 8
By Radix Rehmanniae 100kg, be placed in fridge, be refrigerated to-32 ℃, rise to room temperature, take out, slowly cure to eighty per cant dry, take out, according to < < Chinese Pharmacopoeia > > version in 2010, steam method, steam to black profit, take out, when dry in the sun is slightly dry to crust mucus, cut sheet or piece, dry, obtain Radix Rehmanniae Preparata.
embodiment 9
Get freeze dried fresh Radix Rehmanniae, according to < < Chinese Pharmacopoeia > > version in 2010, steam method, steam to black profit, take out, when dry in the sun is slightly dry to crust mucus, cut sheet or piece, dry, obtain Radix Rehmanniae Preparata.
Claims (3)
1. by Refrigeration Technique, prepare radix rehmanniae, it is characterized in that preparing Radix Rehmanniae and Radix Rehmanniae Preparata by freezing method.
According to claim 1 by Refrigeration Technique, prepare radix rehmanniae, it is characterized in that the method for making of Radix Rehmanniae is: Radix Rehmanniae is refrigerated to below-10 ℃, rises to room temperature, take out and slowly to cure to eighty per cant dry, obtain Radix Rehmanniae.
3. according to claim 1, by Refrigeration Technique, prepare radix rehmanniae, the method for making that it is characterized in that Radix Rehmanniae Preparata is: Radix Rehmanniae is refrigerated to below-10 ℃, rise to room temperature, take out and slowly to cure to eighty per cant dry, according to < < Chinese Pharmacopoeia > > version stewed with wine method in 2010 or steaming method, prepare Radix Rehmanniae Preparata.
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Cited By (1)
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| CN114306460A (en) * | 2021-11-23 | 2022-04-12 | 江西纳弗堂制药有限公司 | Fructus amomi steamed rehmannia decoction pieces and preparation method thereof |
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| CN114306460A (en) * | 2021-11-23 | 2022-04-12 | 江西纳弗堂制药有限公司 | Fructus amomi steamed rehmannia decoction pieces and preparation method thereof |
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Application publication date: 20141119 |