CN103055016A - Freeze-dried fresh rehmannia for treating acne - Google Patents
Freeze-dried fresh rehmannia for treating acne Download PDFInfo
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- CN103055016A CN103055016A CN2013100086614A CN201310008661A CN103055016A CN 103055016 A CN103055016 A CN 103055016A CN 2013100086614 A CN2013100086614 A CN 2013100086614A CN 201310008661 A CN201310008661 A CN 201310008661A CN 103055016 A CN103055016 A CN 103055016A
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Abstract
The invention relates to application of freeze-dried fresh rehmannia in preparation of medicines, and in particular relates to application of freeze-dried fresh rehmannia in preparation of a medicine for treating acne. The medicine includes freeze-dried fresh rehmannia or freeze-dried fresh rehmannia extracts. The freeze-dried fresh rehmannia for treating acne disclosed by the invention has the advantages of obvious effect of acne treatment.
Description
Technical field
The present invention relates to medicine, particularly the medicine of a kind of freeze dried fresh Radix Rehmanniae of Acne treatment preparation belongs to medical technical field.
Background technology
Radix Rehmanniae is the fresh or dried root of scrophulariaceae rehmannia glutinosa plant Rehmannia glutinosa Li-bosch..Excavate autumn, except removing LU, fibrous root and silt, using fresh herb, practises title " Radix Rehmanniae ".It is slowly cured to eighty per cant do, practise and claim " Radix Rehmanniae ".Get Radix Rehmanniae and stew to wine according to stewed with wine method (" Chinese pharmacopoeia version appendix II in 2010 D) and exhaust, take out, when dry in the sun is slightly dried to the crust mucus; Or steam to black profit according to steaming method (" Chinese pharmacopoeia version appendix II in 2010 D), take out, shine when approximately most probably doing, cut sheet or piece, drying namely gets " Radix Rehmanniae Preparata ".The pharmacodynamic feature of these 3 kinds of Radix Rehmanniae is different, and Radix Rehmanniae has the effect of clearing away heat and promoting production of body fluid, removing heat from blood, hemostasis; Radix Rehmanniae has the effect of clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting; Radix Rehmanniae Preparata then has the function that nourishing YIN and supplementing blood, beneficial essence are filled out marrow.
The pharmacological research of Radix Rehmanniae has been subject to paying close attention to widely in recent years, and is widely used in clinical.Be used for hemostasis, be used for diabetes, be used for cardiovascular and cerebrovascular disease, be used for hypertension, be used for nephritis, be used for dull-witted, be used for urinary system, be used for oral ulcer etc.
Acne is a kind of pilosebaceous chronic inflammatory disease dermatoses.Be mainly in the youth, mainly betide facial and thoracic dorsal etc. and locate, show as acne, pimple, pustule, tuberosity, cyst etc., similar with " rosacea caused by lung-wind " of TCM Document record.Put down in writing such as " Yizong Jinjian surgery heart method " rosacea caused by lung-wind: " this card is formed by the lung meridian heat in blood, and every is played broken pimple in the face nose, and shape such as broomcorn millet are considered to be worth doing, and red complexion swells and ache, and breaks out white lead juice.”。We find through long-term research, and freeze dried fresh Radix Rehmanniae Acne treatment has preferably curative effect.
Summary of the invention
The purpose of this invention is to provide with the freeze dried fresh Radix Rehmanniae and prepare application in the Retinoids, Retin-A, Renova, Accutane.
The application of freeze dried fresh Radix Rehmanniae in the preparation medicine, feature is that the freeze dried fresh Radix Rehmanniae prepares the application in the Retinoids, Retin-A, Renova, Accutane, described medicine contains the freeze dried fresh Radix Rehmanniae.
The application of freeze dried fresh Radix Rehmanniae of the present invention in the preparation medicine, feature is that described medicine is prepared by single flavor freeze dried fresh Radix Rehmanniae.
The application of freeze dried fresh Radix Rehmanniae of the present invention in the preparation medicine, feature is the medicine of making, one day taking dose of patient is equivalent to freeze dried fresh Radix Rehmanniae 3-300g.
The application of freeze dried fresh Radix Rehmanniae of the present invention in the preparation medicine, feature is that the freeze dried fresh Radix Rehmanniae is directly pulverized, and makes powder and takes.
The application of freeze dried fresh Radix Rehmanniae of the present invention in the preparation medicine, feature is that described medicine contains the freeze dried fresh Radix Rehmanniae extract.
The application of freeze dried fresh Radix Rehmanniae of the present invention in the preparation medicine, feature is that described medicine is prepared by single flavor freeze dried fresh Radix Rehmanniae extract.
The application of freeze dried fresh Radix Rehmanniae of the present invention in the preparation medicine, feature are according to actual needs, further to add other raw material of Chinese medicine preparations.
The application of freeze dried fresh Radix Rehmanniae of the present invention in the preparation medicine, feature are according to actual needs, further to add other raw material of Chinese medicine preparations.
The purpose of freeze dried fresh Radix Rehmanniae is to solve short, the technical problem such as freight is too high, loss of effective components is larger of Radix Rehmanniae holding time.Directly prepare medicine of the present invention with Radix Rehmanniae in the Radix Rehmanniae harvest season and can reduce cost.Accordingly, the application of freeze dried fresh Radix Rehmanniae of the present invention in the preparation medicine can replace with Radix Rehmanniae at Radix Rehmanniae harvest season medicament freeze-drying Radix Rehmanniae of the present invention, and its consumption is by the Radix Rehmanniae conversion.
So far finished the present invention, the medicine of freeze dried fresh Radix Rehmanniae preparation of the present invention, Acne treatment is evident in efficacy, has no side effect.The beneficial effect of Acne treatment of the present invention is further set forth in following clinical trial.
1. physical data patients with acne 18 examples, male's 14 examples wherein, women's 4 examples, age reckling 12 years old, the maximum 38 years old, the course of disease is the shortest 1 year, and is the longest 3 years.Clinical manifestation mainly contains: seborrhea is obvious, the pustule that acne, the little pimple of red inflammatory, hair follicle pustule and papular top form, red tuberosity.
2. Therapeutic Method is got Radix Rehmanniae, cleans roguing, is cut into the Radix Rehmanniae section of length 5cm; With the sabot of Radix Rehmanniae section, loading amount is about 4Kg/ ㎡; Solidification point is controlled at-28 ℃; After reaching the control temperature, open immediately vacuum pump and be evacuated to below the drying chamber pressure 50Pa, then start heater switch, promote distillation to rise; The temperature of China should be controlled at below 40 ℃; The temperature of resolution phase should be controlled at below 45 ℃.Make the freeze dried fresh Radix Rehmanniae.
Getting the freeze dried fresh Radix Rehmanniae is the solvent reflux, extract, with methanol, reclaim methanol, add water and stir evenly, n-butanol extraction, butanol solution concentrating under reduced pressure, dissolving adds diethyl ether, active carbon kieselguhr mixed column on the insoluble matter take the ethanol of 1-10% as eluant, contains the eluent of catalpol, drying gets the freeze dried fresh Radix Rehmanniae extract.
Get the freeze dried fresh Radix Rehmanniae extract, add carboxymethyl starch sodium, gelatinized corn starch is granulated, drying, and arrangement, the adding Pulvis Talci is an amount of, mixing, tabletting.Every is equivalent to freeze dried fresh Radix Rehmanniae 20g.Each 5, every day 3 times, 15 days is a course for the treatment of.
3. criterion of therapeutical effect is cured: skin lesion is disappeared, and subjective symptoms disappears; Take a turn for the better: subjective symptoms obviously alleviates, and skin lesion disappears more than 30%; Do not heal: skin lesion and symptom be the unchanged or less than 30% that disappears all.
4. efficacy result is through 2 course of therapy, and wherein healing person's 10 examples account for 55.5%; Improvement person's 6 examples account for 33.3%; Person's 2 examples more account for 11.1%, and total effective rate is 88.9%.
The specific embodiment
Embodiment 1
Get the freeze dried fresh Radix Rehmanniae, pulverize, get powder, be packed as the 10g/ bag, Acne treatment, 2 bags of every days, minute 2 clothes.
Embodiment 2
Extracting honeysuckle 15kg, Flos Chrysanthemi Indici 15kg, Herba Taraxaci 15kg, Herba Violae 15kg, Radix Salviae Miltiorrhizae 30kg; With water extraction 2 times, add 8 times of water gagings for the first time, extracted 1.5 hours, add 6 times of water gagings extractions 1 hour for the second time, merge extractive liquid, filters, and is concentrated, drying adds lyophilizing ground bloom 30kg, mixing, starch slurry is granulated, drying, granulate, add Pulvis Talci an amount of, tabletting, Acne treatment, 12 of every days (containing lyophilizing ground bloom 3g), minute 3 clothes, 1 month was 1 course for the treatment of.
Embodiment 3
Get Radix Rehmanniae, clean roguing, be cut into the Radix Rehmanniae section of length 5cm; With the sabot of Radix Rehmanniae section, loading amount is about 4Kg/ ㎡; Solidification point is controlled at-28 ℃; After reaching the control temperature, open immediately vacuum pump and be evacuated to below the drying chamber pressure 50Pa, then start heater switch, promote distillation to rise; The temperature of China should be controlled at below 40 ℃; The temperature of resolution phase should be controlled at below 45 ℃.Make the freeze dried fresh Radix Rehmanniae.
Getting the freeze dried fresh Radix Rehmanniae is the solvent reflux, extract, with methanol, reclaim methanol, add water and stir evenly, n-butanol extraction, butanol solution concentrating under reduced pressure, dissolving adds diethyl ether, active carbon kieselguhr mixed column on the insoluble matter take the ethanol of 1-10% as eluant, contains the eluent of catalpol, drying gets the freeze dried fresh Radix Rehmanniae extract.
Extracting honeysuckle 15kg, Flos Chrysanthemi Indici 15kg, Radix Salviae Miltiorrhizae 30kg, Herba Artemisiae Scopariae 15kg, Bulbus Fritillariae Thunbergii 10kg, Concha Ostreae 30kg; With water extraction 2 times, add 10 times of water gagings for the first time, extracted 2 hours, add 8 times of water gagings for the second time and extracted 1 hour, merge extractive liquid, filters, and concentrates, and drying gets Chinese medicine extract.
Get freeze dried fresh Radix Rehmanniae extract, Chinese medicine extract, add carboxymethyl starch sodium, gelatinized corn starch is granulated, drying, and arrangement, the adding Pulvis Talci is an amount of, mixing, tabletting.Every is equivalent to freeze dried fresh Radix Rehmanniae 10g.The patient who is used for the treatment of acne, each 5, every day 3 times.
Embodiment 4
Extracting honeysuckle 15kg, Herba Taraxaci 15kg, Radix Salviae Miltiorrhizae 30kg, Fructus Crataegi 30kg, Rhizoma Atractylodis Macrocephalae 10kg, Semen Coicis 30kg, Radix Glycyrrhizae 3kg; With water extraction 2 times, add 12 times of water gagings for the first time, extracted 1.5 hours, add 8 times of water gagings for the second time and extracted 1 hour, merge extractive liquid, filters, and concentrates, and drying gets medicinal substances extract.
Get freeze dried fresh Radix Rehmanniae 12kg, use ethanol percolate extraction, the extracting solution Recycled ethanol, drying gets the freeze dried fresh Radix Rehmanniae extract.
Get it filled material extract, freeze dried fresh Radix Rehmanniae extract, mixing adds dextrin, granulates, drying, granulate gets granule, is used for the treatment of acne, every day, 30g(was equivalent to contain lyophilizing Radix Rehmanniae 12g), minute 2 clothes.
Embodiment 5
Extracting honeysuckle 15kg, Herba Taraxaci 15kg, Radix Salviae Miltiorrhizae 30kg, Fructus Crataegi 30kg, Rhizoma Atractylodis Macrocephalae 10kg, Semen Coicis 30kg, Radix Glycyrrhizae 3kg; With water extraction 2 times, add 12 times of water gagings for the first time, extracted 1.5 hours, add 8 times of water gagings for the second time and extracted 1 hour, merge extractive liquid, filters, and concentrates, and drying gets medicinal substances extract.
Get Radix Rehmanniae 150kg, use ethanol percolate extraction, the extracting solution Recycled ethanol, drying gets the Radix Rehmanniae extract.
Get it filled material extract, Radix Rehmanniae extract, mixing adds dextrin, granulates, drying, granulate gets granule, is used for the treatment of acne, every day, 30g(was equivalent to contain lyophilizing Radix Rehmanniae 12g), minute 2 clothes.
Claims (8)
1. the application of freeze dried fresh Radix Rehmanniae in the preparation medicine, feature is that the freeze dried fresh Radix Rehmanniae prepares the application in the Retinoids, Retin-A, Renova, Accutane, described medicine contains the freeze dried fresh Radix Rehmanniae.
2. according to claim 1 freeze dried fresh Radix Rehmanniae is in the application of preparation in the medicine, and feature is that described medicine is prepared by single flavor freeze dried fresh Radix Rehmanniae.
According to claim 1 or the freeze dried fresh Radix Rehmanniae of claim 2 in the application of preparation in the medicine, feature is that one day the taking dose of medicine patient of making is equivalent to freeze dried fresh Radix Rehmanniae 9-300g.
According to claim 1 or the freeze dried fresh Radix Rehmanniae of claim 2 in the application of preparation in the medicine, feature is that the freeze dried fresh Radix Rehmanniae is directly pulverized, and makes preparation and takes.
According to claim 1 or the freeze dried fresh Radix Rehmanniae of claim 2 in the application of preparation in the medicine, feature is that described medicine contains the freeze dried fresh Radix Rehmanniae extract.
According to claim 1 or the freeze dried fresh Radix Rehmanniae of claim 2 or claim 5 in the application of preparation in the medicine, feature is that described medicine is prepared by single flavor freeze dried fresh Radix Rehmanniae extract.
According to claim 1 or the freeze dried fresh Radix Rehmanniae of claim 3 or claim 4 in the application of preparation in the medicine, feature is according to actual needs, further to add other raw material of Chinese medicine preparations.
According to claim 1 or the freeze dried fresh Radix Rehmanniae of claim 2 or claim 2 in the application of preparation in the medicine, feature is that the freeze dried fresh Radix Rehmanniae can replace with Radix Rehmanniae, its consumption is by the Radix Rehmanniae conversion.
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103977041A (en) * | 2014-05-15 | 2014-08-13 | 济南康众医药科技开发有限公司 | Drying method of ganoderma applanatum pat |
| CN104154721A (en) * | 2014-08-25 | 2014-11-19 | 济南康众医药科技开发有限公司 | Rehmannia freeze-drying method |
| CN104147222A (en) * | 2014-08-25 | 2014-11-19 | 济南康众医药科技开发有限公司 | Preparation of raw rehmannia glutinosa and prepared rehmannia glutinosa through freezing method |
| CN104147225A (en) * | 2014-08-25 | 2014-11-19 | 济南康众医药科技开发有限公司 | Freeze-dried rehmannia glutinosa used as high-bioavailability decocting pieces |
| CN104147221A (en) * | 2014-08-25 | 2014-11-19 | 济南康众医药科技开发有限公司 | Freeze-drying method of rehamnnia glutinosa |
| CN104147227A (en) * | 2014-08-25 | 2014-11-19 | 济南康众医药科技开发有限公司 | Freeze-dried rehmannia glutinosa for treating cerebral thrombosis |
| CN104208171A (en) * | 2014-09-29 | 2014-12-17 | 刘昆 | Traditional Chinese medicine composite for treating acne |
| CN105147798A (en) * | 2015-09-29 | 2015-12-16 | 李凤 | Traditional Chinese medicine composition for treating acnes |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103977041A (en) * | 2014-05-15 | 2014-08-13 | 济南康众医药科技开发有限公司 | Drying method of ganoderma applanatum pat |
| CN104154721A (en) * | 2014-08-25 | 2014-11-19 | 济南康众医药科技开发有限公司 | Rehmannia freeze-drying method |
| CN104147222A (en) * | 2014-08-25 | 2014-11-19 | 济南康众医药科技开发有限公司 | Preparation of raw rehmannia glutinosa and prepared rehmannia glutinosa through freezing method |
| CN104147225A (en) * | 2014-08-25 | 2014-11-19 | 济南康众医药科技开发有限公司 | Freeze-dried rehmannia glutinosa used as high-bioavailability decocting pieces |
| CN104147221A (en) * | 2014-08-25 | 2014-11-19 | 济南康众医药科技开发有限公司 | Freeze-drying method of rehamnnia glutinosa |
| CN104147227A (en) * | 2014-08-25 | 2014-11-19 | 济南康众医药科技开发有限公司 | Freeze-dried rehmannia glutinosa for treating cerebral thrombosis |
| CN104208171A (en) * | 2014-09-29 | 2014-12-17 | 刘昆 | Traditional Chinese medicine composite for treating acne |
| CN104208171B (en) * | 2014-09-29 | 2016-10-05 | 刘昆 | A kind of Chinese medicine composition treating acne |
| CN105147798A (en) * | 2015-09-29 | 2015-12-16 | 李凤 | Traditional Chinese medicine composition for treating acnes |
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| CN103055016B (en) | 2014-10-15 |
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Owner name: JI NAN SUNNYPHARMACY CO., LTD. Free format text: FORMER OWNER: JINAN KANGZHONG MEDICIN SCIENCE + TECHNOLOGY CO., LTD. Effective date: 20150429 |
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Effective date of registration: 20150429 Address after: 250200 Shandong Province, Zhangqiu City Industrial Economic Development Zone Mingshui Road Northwest Section Patentee after: Jinan Sunnypharmacy Co., Ltd. Address before: Lixia District Hospital in Shandong province Ji'nan City Road 250014 No. 19 No. 4 West of Shandong Academy of Sciences Patentee before: Jinan Kangzhong Medicin Science & Technology Co., Ltd. |