CN104147227A - Freeze-dried rehmannia glutinosa for treating cerebral thrombosis - Google Patents
Freeze-dried rehmannia glutinosa for treating cerebral thrombosis Download PDFInfo
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- CN104147227A CN104147227A CN201410419040.XA CN201410419040A CN104147227A CN 104147227 A CN104147227 A CN 104147227A CN 201410419040 A CN201410419040 A CN 201410419040A CN 104147227 A CN104147227 A CN 104147227A
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- radix rehmanniae
- cerebral thrombosis
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Abstract
The invention relates to a freeze-dried rehmannia glutinosa for treating cerebral thrombosis. Fresh rehmannia glutinosa is slightly steamed or is heated and then is freeze-dried. The freeze-dried rehmannia glutinosa has better effect on treatment of the cerebral thrombosis and is free of side effects.
Description
Invention field
The present invention relates to medicine, particularly a kind of lyophilizing Radix Rehmanniae for the treatment of cerebral thrombosis, belongs to medical technical field.
Background technology
Radix Rehmanniae is the fresh or dried root of scrophulariaceae rehmannia glutinosa plant Rehmannia glutinosa Li-bosch..Excavate autumn, except removing LU, fibrous root and silt, using fresh herb, practises and claim " Radix Rehmanniae ".It is slowly cured to eighty per cant dry, practise and claim " Radix Rehmanniae ".Get Radix Rehmanniae and stew to wine exhaustion according to stewed with wine method (" Chinese Pharmacopoeia " version appendix II D in 2010), take out, when dry in the sun is slightly dry to crust mucus; Or according to extremely black profit of steaming method (" Chinese Pharmacopoeia " version appendix II D in 2010) steaming, take out, shine while doing to approximately eighty per cant, cut sheet or piece, dry, obtain " Radix Rehmanniae Preparata ".The pharmacodynamic feature of these 3 kinds of Radix Rehmanniae is different, and Radix Rehmanniae has effect of clearing away heat and promoting production of body fluid, removing heat from blood, hemostasis; Radix Rehmanniae has the effect of clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting; Radix Rehmanniae Preparata has the function that nourishing YIN and supplementing blood, beneficial essence are filled out marrow.
The pharmacological research of Radix Rehmanniae has been subject to paying close attention to widely in recent years, and is widely used in clinical.For hemostasis, for diabetes, for cardiovascular and cerebrovascular disease, for hypertension, for nephritis, for dull-witted, for urinary system, for oral ulcer etc.
Summary of the invention
The object of this invention is to provide a kind of lyophilizing Radix Rehmanniae for the treatment of cerebral thrombosis better efficacy.
The object of the present invention is achieved like this:
A lyophilizing Radix Rehmanniae for the treatment of cerebral thrombosis, is characterized in that: get Radix Rehmanniae, lyophilizing after slightly steaming or scalding.
A kind of lyophilizing Radix Rehmanniae for the treatment of cerebral thrombosis of the present invention, is characterized in that: lyophilizing is to be refrigerated to below-20 DEG C, be evacuated to below drying chamber pressure 30Pa, and subliming by heating, the temperature of distillation is controlled at below 40 DEG C, and resolution temperature is controlled at below 45 DEG C, to dry.
So far completed the present invention, the lyophilizing Radix Rehmanniae for the treatment of cerebral thrombosis of the present invention, treatment cerebral thrombosis better efficacy, has no side effect.
Further illustrate the present invention and treat below the beneficial effect of cerebral thrombosis by clinical trial.
One, prepare sample
To clean with a collection of fresh Radix Rehmanniae, section, processes by the following method.
1) Radix Rehmanniae: slowly cure to dry.
2) lyophilizing: put in freeze dryer, be refrigerated to below-10 DEG C, be evacuated to below drying chamber pressure 20Pa subliming by heating; Sublimation temperature is controlled at below 45 DEG C, and distillation finishes, and the temperature of resolution phase is controlled at below 45 DEG C, to dry.
3) scald rear lyophilizing: put in boiling water and scald 2 minutes, take out, put in freeze dryer, be refrigerated to below-10 DEG C, be evacuated to below drying chamber pressure 20Pa subliming by heating; Sublimation temperature is controlled at below 45 DEG C, and distillation finishes, and the temperature of resolution phase is controlled at below 45 DEG C, to dry.
4) steam rear lyophilizing: put and steam in container, when supreme round vapour is steamed in heating with high heat, take out, put in freeze dryer, be refrigerated to below-10 DEG C, be evacuated to below drying chamber pressure 20Pa subliming by heating; Sublimation temperature is controlled at below 45 DEG C, and distillation finishes, and the temperature of resolution phase is controlled at below 45 DEG C, to dry.
Two, the dry Radix Rehmanniae treatment of distinct methods cerebral thrombosis clinical research
1, physical data
150 routine patients all meet the diagnostic criteria of cerebral thrombosis: 1. age of onset is higher; 2. there are arteriosclerosis and history of hypertension; 3. premorbid has transient ischemic attack more; 4. fall ill when quiet rest more, be everlasting after wakeing up and occur symptom; 5. symptom is many increases the weight of gradually within several hours or longer time; 6. most of patients Clear consciousness, and the neurological symptoms such as hemiplegia, aphasia and sign are obvious.Patient is divided into 5 groups, every group of 30 examples.
2, Therapeutic Method
Matched group: acute stage is given dextran 40 glucose injection 500mL intravenous drip, SHENMAI ZHUSHEYE 40mL adds 5% glucose injection 250mL iv drip, citicoline injection 0.5g adds 5% glucose injection 250mL iv drip (glycosuria patient 5% glucose is used normal saline instead), every day 1 time, 15d is 1 course for the treatment of.
Treatment group: add respectively the dry powder of preparing of distinct methods on the basis for the treatment of of control group, 6g/ bag, 2 bags of every days, point 2 clothes freshly.
3, efficacy assessment standard is cured: clinical symptoms, sign disappear substantially, take care of oneself, and language recovery; Effective: clinical symptoms, sign substantially disappear or be clearly better, muscular strength improves 1-3 level, language recovery, and viability part is recovered; Effective: muscular strength improves 1 grade, and language is clearly better; Invalid: muscular strength is increased less than 1 grade, symptom, sign are unchanged.
4, in table 1, there is diarrhoea and the results are shown in Table 2 in result efficacy result.
The dry Radix Rehmanniae treatment of table 1 distinct methods cerebral thrombosis clinical research result
| Group | n | Cure | Effective | Effectively | Invalid | Total effectively (%) |
| Matched group | 30 | 9 | 7 | 3 | 11 | 63.33 |
| Radix Rehmanniae | 30 | 11 | 8 | 5 | 6 | 80.00 |
| Lyophilizing | 30 | 12 | 12 | 2 | 4 | 86.66 |
| Lyophilizing after scalding | 30 | 12 | 13 | 3 | 2 | 93.33 |
| Lyophilizing after steaming | 30 | 13 | 11 | 4 | 2 | 93.33 |
There is diarrhoea result (n=30) in the dry Radix Rehmanniae treatment of table 2 distinct methods cerebral thrombosis
| ? | Matched group | Radix Rehmanniae | Lyophilizing | Lyophilizing after scalding | Lyophilizing after steaming |
| Number of cases | 0 | 3 | 7 | 0 | 0 |
| Incidence rate (%) | 0 | 10 | 23.33 | 0 | 0 |
Above result shows, slightly steams or scald rear lyophilizing Radix Rehmanniae treatment cerebral thrombosis better efficacy, has no side effect.
Detailed description of the invention
embodiment 1
New Radix Rehmanniae is cleaned, and section, puts in boiling water and scalds 2 minutes, takes out, and puts in freeze dryer, is refrigerated to below-10 DEG C, is evacuated to drying chamber pressure 20Pa, subliming by heating; Sublimation temperature is controlled at 45 DEG C, and distillation finishes, and the temperature of resolution phase is controlled at 45 DEG C, to dry.
embodiment 2
New Radix Rehmanniae is cleaned, and section, puts and steams in container, when supreme round vapour is steamed in heating with high heat, takes out, and puts in freeze dryer, is refrigerated to below-20 DEG C, is evacuated to below drying chamber pressure 30Pa subliming by heating; Sublimation temperature is controlled at below 45 DEG C, and distillation finishes, and the temperature of resolution phase is controlled at 50 DEG C, to dry.
embodiment 3
New Radix Rehmanniae is cleaned, and section, puts in boiling water and scalds 5 minutes, takes out, and puts in freeze dryer, is refrigerated to below-30 DEG C, is evacuated to below drying chamber pressure 50Pa subliming by heating; Sublimation temperature is controlled at 50 DEG C, and distillation finishes, and the temperature of resolution phase is controlled at 50 DEG C, to dry.
embodiment 4
New Radix Rehmanniae is cleaned, and section, puts in boiling water and scalds 1 minute, takes out, and puts in freeze dryer, is refrigerated to below-32 DEG C, is evacuated to drying chamber pressure 20Pa, subliming by heating; Sublimation temperature is controlled at 45 DEG C, and distillation finishes, and the temperature of resolution phase is controlled at 45 DEG C, to dry.
embodiment 5
New Radix Rehmanniae is cleaned, and section, puts and steams in container, when supreme round vapour is steamed in heating with high heat, takes out, and puts in freeze dryer, is refrigerated to-15 DEG C, is evacuated to drying chamber pressure 40Pa, subliming by heating; Sublimation temperature is controlled at 50 DEG C, and distillation finishes, and the temperature of resolution phase is controlled at 50 DEG C, to dry.
Claims (2)
1. a lyophilizing Radix Rehmanniae for the treatment of cerebral thrombosis, is characterized in that: get Radix Rehmanniae, lyophilizing after slightly steaming or scalding.
2. according to a kind of lyophilizing Radix Rehmanniae for the treatment of cerebral thrombosis of claim 1, it is characterized in that: lyophilizing is to be refrigerated to below-20 DEG C, is evacuated to below drying chamber pressure 30Pa, subliming by heating, the temperature of distillation is controlled at below 40 DEG C, and resolution temperature is controlled at below 45 DEG C, to dry.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410419040.XA CN104147227B (en) | 2014-08-25 | 2014-08-25 | A kind of lyophilizing Radix Rehmanniae treating cerebral thrombosis |
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| CN201410419040.XA CN104147227B (en) | 2014-08-25 | 2014-08-25 | A kind of lyophilizing Radix Rehmanniae treating cerebral thrombosis |
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| CN104147227A true CN104147227A (en) | 2014-11-19 |
| CN104147227B CN104147227B (en) | 2016-12-07 |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103055016A (en) * | 2013-01-10 | 2013-04-24 | 济南康众医药科技开发有限公司 | Freeze-dried fresh rehmannia for treating acne |
| CN103055022A (en) * | 2013-01-10 | 2013-04-24 | 济南康众医药科技开发有限公司 | Method for processing rehmannia and application for rehmannia in preparation for medicine |
| CN103055019A (en) * | 2013-01-10 | 2013-04-24 | 济南康众医药科技开发有限公司 | Freeze-dried radix rehmanniae recens for treating cerebral thrombus |
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2014
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103055016A (en) * | 2013-01-10 | 2013-04-24 | 济南康众医药科技开发有限公司 | Freeze-dried fresh rehmannia for treating acne |
| CN103055022A (en) * | 2013-01-10 | 2013-04-24 | 济南康众医药科技开发有限公司 | Method for processing rehmannia and application for rehmannia in preparation for medicine |
| CN103055019A (en) * | 2013-01-10 | 2013-04-24 | 济南康众医药科技开发有限公司 | Freeze-dried radix rehmanniae recens for treating cerebral thrombus |
Non-Patent Citations (2)
| Title |
|---|
| 林静: "《药材商品鉴定技术》", 31 March 2013, 化学工业出版社 * |
| 赵应征: "《生物药物制剂学》", 30 June 2011, 浙江大学出版社 * |
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Address after: 250014 Shandong city of Ji'nan Province - Lixia District No. 81 Shandong Road, Luyuan District Patentee after: Kangzhong Medicine Science and Technology Development Co., Ltd., Jinan Address before: Lixia District Hospital in Shandong province Ji'nan City Road 250014 No. 19 No. 4 West of Shandong Academy of Sciences Patentee before: Kangzhong Medicine Science and Technology Development Co., Ltd., Jinan |
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Address after: 250014 81 thousand Buddha Shandong Road, Lixia District, Ji'nan, Shandong Patentee after: Shandong Zhonghong Kang Pharmaceutical Technology Development Co Ltd Address before: 250014 Luyuan District, 81 Qianfo Shandong Road, Lixia District, Jinan City, Shandong Province Patentee before: Jinan Kangzhong Medicin Science & Technology Co., Ltd. |