CN107519450A - A kind of warming and activating meridian Ligusticum wallichii dip promoting blood circulation and removing blood stasis and preparation method thereof - Google Patents
A kind of warming and activating meridian Ligusticum wallichii dip promoting blood circulation and removing blood stasis and preparation method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/533—Leonurus (motherwort)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/714—Aconitum (monkshood)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/754—Evodia
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention discloses a kind of warming and activating meridian Ligusticum wallichii dip promoting blood circulation and removing blood stasis, it is made up of the herbal raw material of following parts by weight：15~25 parts of Ligusticum wallichii, 10~20 parts of evodia rutaecarpa, 10~20 parts of the rhizome of Chinese monkshood, 10~15 parts of semen brassicae, 10~15 parts of almond, 5~10 parts of Radix Angelicae Sinensis, 10~20 parts of motherwort, 10~20 parts of the radix paeoniae rubrathe, 10~15 parts of 9~16 parts of the root bark of tree peony, 10~20 parts of the red sage root, 15~25 parts of Herba Lycopi and root tuber of aromatic turmeric.The invention also discloses the preparation method of warming and activating meridian Ligusticum wallichii dip promoting blood circulation and removing blood stasis, crushes enzymolysis, microbial fermentation and ultrasonic wave adverse current by raw material and is extracted as key step and is made.Herbal raw material source of the present invention is wide, and cheap, scientific formulation is reasonable, and preparation technology is simple, and extraction Chinese herbal medicine functional components are high, product safety environmental protection, promoting blood circulation and removing blood stasis warming and activating meridian significant effect without any side effects to human body.
Description
Technical field
The invention discloses a kind of dip, more particularly to a kind of warming and activating meridian Ligusticum wallichii dip promoting blood circulation and removing blood stasis and its preparation
Method, belong to traditional Chinese medicine field.
Background technology
With the work of the allegro life style of modern and high-strength high-voltage power so that the time of exercise is increasingly
Few, neck, shoulder, waist, the numbness patient for the pain that has a pain in the leg gradually increase, and have seriously endangered the health of people.Numbness disease refers to body healthy tendency
The perverse trends such as deficiency, weakened defensive QI, wind, cold, wet, heat are taken advantage of a weak point, and are caused qi and blood stagnation, obstruction of meridians and collaterals, are caused related system disease
The general name of disease.Narrow sense numbness disease, that is, refer to limbs channels and collaterals numbness therein, with muscle, muscles and bones, joint occur pain, numbness, weigh,
Joint stuffiness, or even the scorching hot disease for main clinical manifestation of arthrocele.
Numbness disease can use Chinese and Western medicine anti symptom treatment, can take some analgesic-antipyretic during such as pain, B races can be selected in numb person
Vitamin medicaments, but drug oral, gastrointestinal reaction is obvious, larger to liver, renal damage；Arthroncus has hydrops, and person can give
It is local to extract the therapy such as hydrops or partial closure, but the treatment method is undesirable, and the state of an illness easily recurs.Or the method with physiotherapy,
Galvanoiontophoresis method has given full play to the effect of medicine, but is liquid because importing medicine, and volatile, drug effect is not held
Long, the therapeutic effect of this method is limited.It is certain that other can use the treatment methods such as ultraviolet, infrared ray, microwave, laser to have
Effect, but have limitation.Because numbness disease is common disease, the incidence of disease is very high, more stubborn and stupid, takes in general treatment method most
It is not easy to cure, causes that the course of disease is long, cost is more, rehabilitation is slow, heavier burden is brought to patient and family members.
Dipping has original effect to human body, with a history of thousands of years in China, since ancient times always by medical field weight
Depending on.Dipping method is one of external therapy, i.e., a variety of with decoction or a kind of method containing decoction water washing bath whole body or part, its form
It is various.In general, medicine acts on whole body fleshy exterior, part, affected part to the dipping mechanism of action, and through absorbing, circulation channels and collaterals blood vessels are interior
Up to internal organs, from outward appearance to inner essence, thus effect is produced.Dipping bathing, can play dredging the channel, activate blood circulation and disperse blood clots, wind dispelling cold dispelling, heat-clearing solution
Poison, swelling and pain relieving, negative and positive are adjusted, coordinates internal organs, current qi and blood, moisten the health maintenance effects such as foster whole body.Dipping avoids medicine to spleen
The stimulation of stomach and the infringement to liver, effective ingredient is absorbed by skin to play effect, be the various chronic diseases of preventing and treating
Disease and the Perfected process of health care.
Chinese herbal medicine is the rarity of Chinese traditional culture, proves that a variety of Chinese herbal medicines have in practice and enhances metabolism, changes
Kind blood circulation, promoting blood circulation and removing blood stasis, warming and activating meridian, expelling wind and clearing away cold, expelling pathogenic factors from muscles and skin dehumidifying, strengthening the muscles and bones, relaxing tendons and activating collaterals, make inquiries active work(of Denging
Effect, therefore, is applied to warming and activating meridian promoting blood circulation and removing blood stasis by Chinese herbal medicine, treats various numbness diseases for improving national life quality, ensures
Living safety tool is of great significance, but Chinese herbal medicine warming and activating meridian dipping promoting blood circulation and removing blood stasis at present not yet realizes scale in application
Change and industrialization, subject matter is that Chinese herbal medicine compatibility is unreasonable, functional component recovery rate is low, be difficult to industrialized production, effect not
The drawback such as notable, therefore develop new warming and activating meridian dipping promoting blood circulation and removing blood stasis and have important practical significance.
The content of the invention
It is an object of the invention to the above mentioned problem according to existing for existing warming and activating meridian product promoting blood circulation and removing blood stasis, develops a kind of living
Blood stagnation resolvation warming and activating meridian Ligusticum wallichii dip, people is passed through dipping to promote body metabolism, improve body blood circulation, relax
Muscle is invigorated blood circulation, and is made inquiries active, expelling wind and clearing away cold, expelling pathogenic factors from muscles and skin dehumidifying, strengthening the muscles and bones, the cause of disease is dispelled from root, allows people away from numbness disease
Puzzlement.
To achieve these goals, the present invention uses following technical scheme：
A kind of warming and activating meridian Ligusticum wallichii dip promoting blood circulation and removing blood stasis, is made up of the herbal raw material of following parts by weight：15~25 parts of Ligusticum wallichii,
10~20 parts of evodia rutaecarpa, 10~20 parts of the rhizome of Chinese monkshood, 10~15 parts of semen brassicae, 10~15 parts of almond, 5~10 parts of Radix Angelicae Sinensis, motherwort 10
~20 parts, 10~20 parts of the radix paeoniae rubrathe, 9~16 parts of the root bark of tree peony, 10~20 parts of the red sage root, 10~15 parts of 15~25 parts of Herba Lycopi and root tuber of aromatic turmeric.
The preparation method of present invention warming and activating meridian Ligusticum wallichii dip promoting blood circulation and removing blood stasis, comprises the following steps：
（1）Stock：The impurity in herbal raw material is rejected, goes mouldy with after infested raw material, is stocked up according to aforementioned proportion；
（2）Feedstock treating：Herbal raw material is cleaned up, at 60~75 DEG C, after air blast drying, pulverizer crushes, and crosses 50
~100 mesh sieves, mix, obtain composite Chinese herbal raw material；
（3）Enzymolysis：By step（2）Gained composite Chinese herbal raw material adds water to solid-to-liquid ratio 1：2~4, by 2.0~3.0 g/L, 2.0
~4.0 g/L ratios add non-starch polysaccharide enzyme, cellulase respectively, under the effect of 600 ~ 900 W ultrasonic assistants, 40~
The min of coordinated enzymatic hydrolysis 30~50 under the conditions of 50 DEG C；
（4）Microbial fermentation：To step（3）The Bifidobacterium added in gained Enzymolysis liquid after 3~5% activation（Viable count >=
20000000000/ml）, ferment under anaerobic condition 12~18 h, controls 28~35 DEG C of fermentation temperature；
（5）Centrifugation：Solid residue and supernatant are centrifuged after fermentation ends；
（6）Ultrasonic adverse current is extracted：By step（5）Obtained solid residue, 3~5 times of 50~60% ethanol are added, are put into ultrasound
In Continuous Countercurrent Extraction machine, under the effect of 600 ~ 900 W ultrasonic assistants, after adverse current extracts 30 ~ 60 min, 120 ~ 180 mesh are crossed
Filter cloth obtains extract solution.Filter residue carries out ultrasonic continuous countercurrent and extracted 1 time in the same way, merges extract solution twice；
（7）It is concentrated under reduced pressure：By step（6）The extract solution of gained is at 60~75 DEG C of temperature, vacuum -0.06~-0.085
It is evaporated under reduced pressure under MPa, reclaims the ethanol in extracts of Chinese herbal medicine to without alcohol taste, obtain removing ethanol extracts of Chinese herbal medicine；
（8）Filtering：By step（5）Gained supernatant and step（7）The removal ethanol extracts of Chinese herbal medicine of gained mixes, through diatom
Filter is filtered to remove impurity and insoluble matter therein, produces warming and activating meridian Ligusticum wallichii dip promoting blood circulation and removing blood stasis.
The present invention provides a kind of warming and activating meridian Ligusticum wallichii dip promoting blood circulation and removing blood stasis, the characteristic of each Chinese herbal medicine in combined formulation, in
Cure dialectical theory to be developed, scientific formulation is reasonable, acts synergistically between each component, proves the present invention to various wind by long-term use
Cold-dampness bi Zheng, including pain in the back, skelagia, cervical spondylopathy, scapulohumeral periarthritis and femoral head disease, spinal canal stenosis, osteoproliferation have good treatment
Effect.Advantage of the invention is that：（1）Product is not required to by body absorption using medicine during dipping, and drug effect is directly acted on into trouble
Place, safety and environmental protection, mild in medicine property and, it is without any side effects to human body；（2）Product has pleasant Chinese herbal medicine delicate fragrance, easy to use,
This product need to be only taken during use by 1：400~800 ratios are called in heating bath water, can carry out immersion bathing；（3）With medical bathing powder list
Pure addition is compared, and the present invention crushes enzymolysis, microbial fermentation and ultrasonic wave adverse current using raw material and is extracted as main preparation section, has
Improve Chinese herbal medicine functional components, warming and activating meridian significant effect promoting blood circulation and removing blood stasis in effect ground；（4）Raw material sources are wide in the present invention, price
Cheap, production and processing technology is simple, is adapted to large-scale production.
Embodiment
Below by embodiment, the present invention will be further described.In the present invention, if not refering in particular to, Suo Youbai
Point ratio is unit of weight, and all devices and raw material are commercially available or the industry is commonly used, in following embodiments
Method, it is this area conventional method unless otherwise instructed.
Embodiment 1
A kind of warming and activating meridian Ligusticum wallichii dip promoting blood circulation and removing blood stasis, is made up of the herbal raw material of following each component：Ligusticum wallichii, evodia rutaecarpa,
The rhizome of Chinese monkshood, semen brassicae, almond, Radix Angelicae Sinensis, motherwort, the radix paeoniae rubrathe, the root bark of tree peony, the red sage root, Herba Lycopi and root tuber of aromatic turmeric.The tool of each component in herbal raw material
Body proportioning is as shown in table 1.
The preparation method of present invention warming and activating meridian Ligusticum wallichii dip promoting blood circulation and removing blood stasis, comprises the following steps：
（1）Stock：The impurity in herbal raw material is rejected, goes mouldy with after infested raw material, is stocked up according to aforementioned proportion；
（2）Feedstock treating：Herbal raw material is cleaned up, at 75 DEG C, after air blast drying, pulverizer crushes, and crosses 80 mesh
Sieve, mix, obtain composite Chinese herbal raw material；
（3）Enzymolysis：By step（2）Gained composite Chinese herbal raw material adds water to solid-to-liquid ratio 1：3, in 2.8 g/L, 2.5 g/L ratios
Non-starch polysaccharide enzyme, cellulase are added respectively, under the effect of 750 W ultrasonic assistants, the coordinated enzymatic hydrolysis 35 under the conditions of 42 DEG C
min；
（4）Microbial fermentation：To step（3）The Bifidobacterium added in gained Enzymolysis liquid after 4% activation（Viable count >=200
Hundred million/ml）, ferment under anaerobic condition 18 h, controls 30 DEG C of fermentation temperature；
（5）Centrifugation：Solid residue and supernatant are centrifuged after fermentation ends；
（6）Ultrasonic adverse current is extracted：By step（5）Obtained solid residue, 5 times of 52% ethanol is added, is put into ultrasonic continuous countercurrent
In extractor, under the effect of 700 W ultrasonic assistants, after adverse current extracts 45 min, cross 120 mesh filter clothes and obtain extract solution.Filter residue is pressed
Same method carries out ultrasonic continuous countercurrent and extracted 1 time, merges extract solution twice；
（7）It is concentrated under reduced pressure：By step（6）The extract solution of gained is depressurized at 72 DEG C of temperature under the MPa of vacuum -0.07
Distillation, the ethanol in extracts of Chinese herbal medicine is reclaimed to without alcohol taste, obtains removing ethanol extracts of Chinese herbal medicine；
（8）Filtering：By step（5）Gained supernatant and step（7）The removal ethanol extracts of Chinese herbal medicine of gained mixes, through diatom
Filter is filtered to remove impurity and insoluble matter therein, produces warming and activating meridian Ligusticum wallichii dip promoting blood circulation and removing blood stasis.
Embodiment 2
A kind of warming and activating meridian Ligusticum wallichii dip promoting blood circulation and removing blood stasis, is made up of the herbal raw material of following each component：Ligusticum wallichii, evodia rutaecarpa,
The rhizome of Chinese monkshood, semen brassicae, almond, Radix Angelicae Sinensis, motherwort, the radix paeoniae rubrathe, the root bark of tree peony, the red sage root, Herba Lycopi and root tuber of aromatic turmeric.The tool of each component in herbal raw material
Body proportioning is as shown in table 1.
The preparation method of present invention warming and activating meridian Ligusticum wallichii dip promoting blood circulation and removing blood stasis, comprises the following steps：
（1）Stock：The impurity in herbal raw material is rejected, goes mouldy with after infested raw material, is stocked up according to aforementioned proportion；
（2）Feedstock treating：Herbal raw material is cleaned up, at 70 DEG C, after air blast drying, pulverizer crushes, and crosses 60 mesh
Sieve, mix, obtain composite Chinese herbal raw material；
（3）Enzymolysis：By step（2）Gained composite Chinese herbal raw material adds water to solid-to-liquid ratio 1：2, in 2.4 g/L, 3.5 g/L ratios
Non-starch polysaccharide enzyme, cellulase are added respectively, under the effect of 800 W ultrasonic assistants, the coordinated enzymatic hydrolysis 40 under the conditions of 46 DEG C
min；
（4）Microbial fermentation：To step（3）The Bifidobacterium added in gained Enzymolysis liquid after 3% activation（Viable count >=200
Hundred million/ml）, ferment under anaerobic condition 15 h, controls 32 DEG C of fermentation temperature；
（5）Centrifugation：Solid residue and supernatant are centrifuged after fermentation ends；
（6）Ultrasonic adverse current is extracted：By step（5）Obtained solid residue, 4 times of 56% ethanol is added, is put into ultrasonic continuous countercurrent
In extractor, under the effect of 750 W ultrasonic assistants, after adverse current extracts 55 min, cross 180 mesh filter clothes and obtain extract solution.Filter residue is pressed
Same method carries out ultrasonic continuous countercurrent and extracted 1 time, merges extract solution twice；
（7）It is concentrated under reduced pressure：By step（6）The extract solution of gained is depressurized at 68 DEG C of temperature under the MPa of vacuum -0.06
Distillation, the ethanol in extracts of Chinese herbal medicine is reclaimed to without alcohol taste, obtains removing ethanol extracts of Chinese herbal medicine；
（8）Filtering：By step（5）Gained supernatant and step（7）The removal ethanol extracts of Chinese herbal medicine of gained mixes, through diatom
Filter is filtered to remove impurity and insoluble matter therein, produces warming and activating meridian Ligusticum wallichii dip promoting blood circulation and removing blood stasis.
Embodiment 3
A kind of warming and activating meridian Ligusticum wallichii dip promoting blood circulation and removing blood stasis, is made up of the herbal raw material of following each component：Ligusticum wallichii, evodia rutaecarpa,
The rhizome of Chinese monkshood, semen brassicae, almond, Radix Angelicae Sinensis, motherwort, the radix paeoniae rubrathe, the root bark of tree peony, the red sage root, Herba Lycopi and root tuber of aromatic turmeric.The tool of each component in herbal raw material
Body proportioning is as shown in table 1.
The preparation method of present invention warming and activating meridian Ligusticum wallichii dip promoting blood circulation and removing blood stasis, comprises the following steps：
（1）Stock：The impurity in herbal raw material is rejected, goes mouldy with after infested raw material, is stocked up according to aforementioned proportion；
（2）Feedstock treating：Herbal raw material is cleaned up, at 65 DEG C, after air blast drying, pulverizer crushes, and crosses 100 mesh
Sieve, mix, obtain composite Chinese herbal raw material；
（3）Enzymolysis：By step（2）Gained composite Chinese herbal raw material adds water to solid-to-liquid ratio 1：4, in 2.0 g/L, 3.0 g/L ratios
Non-starch polysaccharide enzyme, cellulase are added respectively, under the effect of 850 W ultrasonic assistants, the coordinated enzymatic hydrolysis 45 under the conditions of 48 DEG C
min；
（4）Microbial fermentation：To step（3）The Bifidobacterium added in gained Enzymolysis liquid after 5% activation（Viable count >=200
Hundred million/ml）, ferment under anaerobic condition 12 h, controls 34 DEG C of fermentation temperature；
（5）Centrifugation：Solid residue and supernatant are centrifuged after fermentation ends；
（6）Ultrasonic adverse current is extracted：By step（5）Obtained solid residue, 3 times of 60% ethanol is added, is put into ultrasonic continuous countercurrent
In extractor, under the effect of 850 W ultrasonic assistants, after adverse current extracts 55 min, cross 150 mesh filter clothes and obtain extract solution.Filter residue is pressed
Same method carries out ultrasonic continuous countercurrent and extracted 1 time, merges extract solution twice；
（7）It is concentrated under reduced pressure：By step（6）The extract solution of gained is depressurized at 64 DEG C of temperature under the MPa of vacuum -0.08
Distillation, the ethanol in extracts of Chinese herbal medicine is reclaimed to without alcohol taste, obtains removing ethanol extracts of Chinese herbal medicine；
（8）Filtering：By step（5）Gained supernatant and step（7）The removal ethanol extracts of Chinese herbal medicine of gained mixes, through diatom
Filter is filtered to remove impurity and insoluble matter therein, produces warming and activating meridian Ligusticum wallichii dip promoting blood circulation and removing blood stasis.
The composition and ratio of each embodiment herbal raw material of table 1.
| Sequence number | Component | Embodiment 1 | Embodiment 2 | Embodiment 3 |
| 1 | Ligusticum wallichii（Part） | 18 | 21 | 24 |
| 2 | Evodia rutaecarpa（Part） | 19 | 16 | 12 |
| 3 | The rhizome of Chinese monkshood（Part） | 15 | 19 | 13 |
| 4 | Semen brassicae（Part） | 11 | 13 | 15 |
| 5 | Almond（Part） | 11 | 14 | 12 |
| 6 | Radix Angelicae Sinensis（Part） | 6 | 9 | 7 |
| 7 | Motherwort（Part） | 19 | 16 | 17 |
| 8 | The radix paeoniae rubrathe（Part） | 15 | 12 | 19 |
| 9 | The root bark of tree peony（Part） | 11 | 14 | 12 |
| 10 | The red sage root（Part） | 17 | 18 | 13 |
| 11 | Herba Lycopi（Part） | 23 | 19 | 16 |
| 12 | Root tuber of aromatic turmeric（Part） | 14 | 11 | 13 |
| 13 | Summation（Part） | 179 | 182 | 173 |
Although to reach illustration purpose, described above is the preferred embodiments of the present invention, is not intended to limit the invention, to the greatest extent
The present invention is described in detail with reference to the foregoing embodiments for pipe, and for those skilled in the art, it still can be with
The technical scheme recorded to foregoing embodiments is modified, or carries out equivalent substitution to which part technical characteristic.It is all
Within the spirit and principles in the present invention, any modification, equivalent substitution and improvements made etc., the protection of the present invention should be included in
Within the scope of.
Claims (2)
1. a kind of warming and activating meridian Ligusticum wallichii dip promoting blood circulation and removing blood stasis, it is characterised in that by following herbal raw material system by weight
Into：15~25 parts of Ligusticum wallichii, 10~20 parts of evodia rutaecarpa, 10~20 parts of the rhizome of Chinese monkshood, 10~15 parts of semen brassicae, 10~15 parts of almond, Radix Angelicae Sinensis 5
~10 parts, 10~20 parts of motherwort, 10~20 parts of the radix paeoniae rubrathe, 9~16 parts of the root bark of tree peony, 10~20 parts of the red sage root, 15~25 parts of Herba Lycopi and strongly fragrant
10~15 parts of gold.
A kind of 2. preparation method of warming and activating meridian Ligusticum wallichii dip promoting blood circulation and removing blood stasis as claimed in claim 1, it is characterised in that bag
Include following steps：
（1）Stock：The impurity in herbal raw material is rejected, goes mouldy with after infested raw material, is stocked up according to aforementioned proportion；
（2）Feedstock treating：Herbal raw material is cleaned up, at 60~75 DEG C, after air blast drying, pulverizer crushes, and crosses 50
~100 mesh sieves, mix, obtain composite Chinese herbal raw material；
（3）Enzymolysis：By step（2）Gained composite Chinese herbal raw material adds water to solid-to-liquid ratio 1：2~4, by 2.0~3.0 g/L, 2.0
~4.0 g/L ratios add non-starch polysaccharide enzyme, cellulase respectively, under the effect of 600 ~ 900 W ultrasonic assistants, 40~
The min of coordinated enzymatic hydrolysis 30~50 under the conditions of 50 DEG C；
（4）Microbial fermentation：To step（3）The Bifidobacterium added in gained Enzymolysis liquid after 3~5% activation（Viable count >=
20000000000/ml）, ferment under anaerobic condition 12~18 h, controls 28~35 DEG C of fermentation temperature；
（5）Centrifugation：Solid residue and supernatant are centrifuged after fermentation ends；
（6）Ultrasonic adverse current is extracted：By step（5）Obtained solid residue, 3~5 times of 50~60% ethanol are added, are put into ultrasound
In Continuous Countercurrent Extraction machine, under the effect of 600 ~ 900 W ultrasonic assistants, after adverse current extracts 30 ~ 60 min, 120 ~ 180 mesh are crossed
Filter cloth obtains extract solution；Filter residue carries out ultrasonic continuous countercurrent and extracted 1 time in the same way, merges extract solution twice；
（7）It is concentrated under reduced pressure：By step（6）The extract solution of gained is at 60~75 DEG C of temperature, vacuum -0.06~-0.085
It is evaporated under reduced pressure under MPa, reclaims the ethanol in extracts of Chinese herbal medicine to without alcohol taste, obtain removing ethanol extracts of Chinese herbal medicine；
（8）Filtering：By step（5）Gained supernatant and step（7）The removal ethanol extracts of Chinese herbal medicine of gained mixes, through diatom
Filter is filtered to remove impurity and insoluble matter therein, produces warming and activating meridian Ligusticum wallichii dip promoting blood circulation and removing blood stasis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710727786.0A CN107519450A (en) | 2017-08-23 | 2017-08-23 | A kind of warming and activating meridian Ligusticum wallichii dip promoting blood circulation and removing blood stasis and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710727786.0A CN107519450A (en) | 2017-08-23 | 2017-08-23 | A kind of warming and activating meridian Ligusticum wallichii dip promoting blood circulation and removing blood stasis and preparation method thereof |
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| CN107519450A true CN107519450A (en) | 2017-12-29 |
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|---|---|---|---|
| CN201710727786.0A Pending CN107519450A (en) | 2017-08-23 | 2017-08-23 | A kind of warming and activating meridian Ligusticum wallichii dip promoting blood circulation and removing blood stasis and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111110750A (en) * | 2020-02-23 | 2020-05-08 | 陕西浚源堂健康信息咨询有限公司 | Medicinal bath for warming channel, dispelling cold, promoting blood circulation and removing blood stasis and preparation method thereof |
-
2017
- 2017-08-23 CN CN201710727786.0A patent/CN107519450A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111110750A (en) * | 2020-02-23 | 2020-05-08 | 陕西浚源堂健康信息咨询有限公司 | Medicinal bath for warming channel, dispelling cold, promoting blood circulation and removing blood stasis and preparation method thereof |
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Application publication date: 20171229 |