CN107441272A - A kind of root of Chinese clematis expelling wind and clearing away cold dip and preparation method thereof - Google Patents

A kind of root of Chinese clematis expelling wind and clearing away cold dip and preparation method thereof Download PDF

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CN107441272A
CN107441272A CN201710727825.7A CN201710727825A CN107441272A CN 107441272 A CN107441272 A CN 107441272A CN 201710727825 A CN201710727825 A CN 201710727825A CN 107441272 A CN107441272 A CN 107441272A
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parts
root
raw material
clearing away
expelling wind
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廖艳卿
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    • A—HUMAN NECESSITIES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
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Abstract

The invention discloses a kind of root of Chinese clematis expelling wind and clearing away cold dip, and it is made up of the herbal raw material of following parts by weight：20~30 parts of the root of Chinese clematis, 15~20 parts of tetrandra root, 10~20 parts of cortex acanthopanacis, 5~10 parts of notopterygium root, 10~15 parts of levisticum, 4~8 parts of Ligusticum wallichii, 5~10 parts of the radix paeoniae rubrathe, 3~6 parts of safflower, 10~15 parts of 10~20 parts of rhizoma homalonemae, 5~10 parts of reticulate millettia, 10~15 parts of caulis piperis futokadsurae and caulis sinomenii.The invention also discloses the preparation method of root of Chinese clematis expelling wind and clearing away cold dip, by raw material crush enzymolysis, microbial fermentation, ultrasonic assistant flooding and ultrasonic assistant alcohol extract based on want step to be made.Herbal raw material source of the present invention is wide, and cheap, scientific formulation is reasonable, and preparation technology is simple, and extraction Chinese herbal medicine functional components are high, product safety environmental protection, expelling wind and clearing away cold significant effect without any side effects to human body.

Description

A kind of root of Chinese clematis expelling wind and clearing away cold dip and preparation method thereof
Technical field
The invention discloses a kind of dip, more particularly to a kind of root of Chinese clematis expelling wind and clearing away cold dip and preparation method thereof, Belong to traditional Chinese medicine field.
Background technology
Wind-cold-dampness arthralgia is the gas exopathogen of wind, cold, wet three invasion and attack collaterals of human, causes qi and blood impatency not smooth, causes joint, limbs Etc. there is acid, pain, fiber crops, weight and the symptom such as joint stuffiness.Be found in the rheumatic fever of modern medical diagnosis, rheumatic arthritis, Rheumatoid arthritis, fibrositis and neuralgia etc..
Positive unsaturated vapor is internal factor and the basis of lesion of numbness disease.Catch cold damp evil, more because moist at residence, paddle and emit Rain, or doss and work as wind, or emit mist dew, climate change, the cold and hot reason such as staggeredly, attacked so that wind-cold damp pathogen is taken advantage of a weak point in opponent's defence caused by human body. The improper life style of modern such as summer stays in air-conditioned room for a long time, long-time blower fan, largely drinks cold drink and eats cold dish, these Wind-cold-dampness arthralgia can be caused.
Arthralgia due to wind-cold-dampness disease can use Chinese and Western medicine anti symptom treatment, can take some analgesic-antipyretic during such as pain；Numb person can From B family vitamin class medicine；Arthroncus has hydrops, and person can give the local extraction therapy such as hydrops or partial closure, but these Treatment method is undesirable, and the state of an illness easily recurs.The physical therapy method of wind-cold-dampness arthralgia is fully sent out using galvanoiontophoresis method The effect of medicine has been waved, but has been liquid because importing medicine, volatile, drug effect is not lasting, limits the therapeutic effect of this method.Its He can use the treatment methods such as ultraviolet, infrared ray, microwave, laser to have certain effect, but because the card is more stubborn and stupid, Take in general treatment method majority to be not easy to cure, cause that the course of disease is long, cost is more, rehabilitation is slow, brought to patient and family members heavier Burden.
Dipping has original effect to human body, with a history of thousands of years in China, since ancient times always by medical field weight Depending on.Dipping method is one of external therapy, i.e., a variety of with decoction or a kind of method containing decoction water washing bath whole body or part, its form It is various.In general, medicine acts on whole body fleshy exterior, part, affected part to the dipping mechanism of action, and through absorbing, circulation channels and collaterals blood vessels are interior Up to internal organs, from outward appearance to inner essence, thus effect is produced.Dipping bathing, can play dredging the channel, activate blood circulation and disperse blood clots, wind dispelling cold dispelling, heat-clearing solution Poison, swelling and pain relieving, negative and positive are adjusted, coordinates internal organs, current qi and blood, moisten the health maintenance effects such as foster whole body.Dipping avoids medicine to spleen The stimulation of stomach and the infringement to liver, effective ingredient is absorbed by skin to play effect, be the various chronic diseases of preventing and treating Disease and the Perfected process of health care.
Chinese herbal medicine is the rarity of Chinese traditional culture, proves that a variety of Chinese herbal medicines have in practice and enhances metabolism, changes Kind blood circulation, the strong kidney of tonifying liver, make inquiries active, expelling wind and clearing away cold, expelling pathogenic factors from muscles and skin dehumidifying, strengthening the muscles and bones and other effects.Therefore, should by Chinese herbal medicine For expelling wind and clearing away cold for improving national life quality, guarantee living safety tool is of great significance, but current Chinese herbal medicine Expelling wind and clearing away cold dipping not yet realizes scale and industrialization in application, and subject matter is that Chinese herbal medicine compatibility is unreasonable, functional component The drawbacks such as recovery rate is low, be difficult to industrialized production, effect is not notable, thus develop new expelling wind and clearing away cold dipping have it is important Realistic meaning.
The content of the invention
It is an object of the invention to the above mentioned problem according to existing for existing expelling wind and clearing away cold product, a kind of root of Chinese clematis wind-dispelling is developed Cold dispelling dip, people is passed through whole body dipping to promote body metabolism, improve body blood circulation, the strong kidney of tonifying liver, ask Tianjin is active, expelling wind and clearing away cold, expelling pathogenic factors from muscles and skin dehumidifying, strengthening the muscles and bones, the cause of disease is dispelled from root, allows puzzlement of the people away from wind-cold-dampness arthralgia.
To achieve these goals, the present invention uses following technical scheme：
A kind of root of Chinese clematis expelling wind and clearing away cold dip, is made up of the herbal raw material of following parts by weight：20~30 parts of the root of Chinese clematis, tetrandra root 15~20 parts, 10~20 parts of cortex acanthopanacis, 5~10 parts of notopterygium root, 10~15 parts of levisticum, 4~8 parts of Ligusticum wallichii, 5~10 parts of the radix paeoniae rubrathe, safflower 3 ~6 parts, 10~20 parts of rhizoma homalonemae, 5~10 parts of reticulate millettia, 10~15 parts of 10~15 parts of caulis piperis futokadsurae and caulis sinomenii.
The preparation method of root of Chinese clematis expelling wind and clearing away cold dip of the present invention, comprises the following steps：
（1）Stock：The impurity in herbal raw material is rejected, goes mouldy with after infested raw material, is stocked up according to aforementioned proportion；
（2）Feedstock treating：Herbal raw material is cleaned up, at 60~75 DEG C, after air blast drying, pulverizer crushes, and crosses 40 ~80 mesh sieves, mix, obtain composite Chinese herbal raw material；
（3）Enzymolysis：By step（2）Gained composite Chinese herbal raw material adds water to solid-to-liquid ratio 1：3~5, by 1.0~2.0 g/L, 0.8 ~1.5 g/L, 1.5~2.5 g/L ratios add non-starch polysaccharide enzyme, carbohydrase, cellulase respectively, surpass in 600 ~ 1000 W Under sound wave booster action, the min of coordinated enzymatic hydrolysis 40~60 under the conditions of 40~50 DEG C；
（4）Microbial fermentation：To step（3）The Bifidobacterium added in gained Enzymolysis liquid after 3~5% activation（Viable count >= 20000000000/ml）, ferment under anaerobic condition 12~15 h, controls 30~35 DEG C of fermentation temperature；
（5）Ultrasonic assistant flooding：By step（4）Microbial fermentation mixed liquor, 80~90 DEG C are warmed to, in 600 ~ 800 W Under ultrasonic assistant effect, 60 ~ 75 min are extracted, after extraction terminates, 150 ~ 200 mesh filter clothes is crossed and obtains water extract.Filter residue adds 3 ~ 5 Times pure water, carries out Ultrasonic Wave-Assisted Extraction, filters to get filtrate in the same way, and it is water extract to merge extract solution twice；
（6）Ultrasonic assistant alcohol steep：To step（5）The ethanol that 3~6 times of concentration are 55~65% is added in gained filter residue, Under the conditions of 600~800 W ultrasonic assistants, 40~60 min, 60~75 DEG C of extraction temperature are extracted；
（7）Centrifugation：Extraction centrifuges solid residue and alcohol extract after terminating；
（8）Concentration distillation：Alcohol extract is concentrated under reduced pressure and is distilled to recover ethanol；
（9）Mixing：By step（5）Water extract and step（8）Reclaim the leaching liquor mixing after ethanol；
（10）Filtering：Mixed liquor is filtered to remove impurity and insoluble matter therein through diatom filter and produces root of Chinese clematis expelling wind and clearing away cold Dip.
The present invention provides a kind of root of Chinese clematis expelling wind and clearing away cold dip, the characteristic of each Chinese herbal medicine in combined formulation, using Chinese medical discrimination Theory is developed, and scientific formulation is reasonable, is acted synergistically between each component, proves that the present invention has expelling wind and clearing away cold by long-term use, Expelling pathogenic factors from muscles and skin dehumidifies, the strong kidney of tonifying liver, strengthening the muscles and bones effect, to various caused by wind, cold and wetness evils, including pain in the back, skelagia, cervical spondylopathy, scapulohumeral periarthritis and Femoral head disease, spinal canal stenosis, osteoproliferation have the effect of good.Advantage of the invention is that：（1）Medicine when product uses dipping Thing is not required to by body absorption, and drug effect directly acted on into affected part, safety and environmental protection, mild in medicine property and, it is without any side effects to human body； （2）Product has pleasant Chinese herbal medicine delicate fragrance, easy to use, need to only take this product by 1 during use：300~600 ratios call in heat In bath water, immersion bathing can be carried out；（3）Compared with medical bathing powder adds merely, the present invention crushes enzymolysis, microorganism using raw material Preparation process is wanted based on fermentation, ultrasonic assistant flooding and the extraction of ultrasonic assistant alcohol, Chinese herbal medicine functional components is improved, dispels Wind, dissipating cold effect is notable；（4）Raw material sources are wide in the present invention, cheap, and production and processing technology is simple, are adapted to scale metaplasia Production.
Embodiment
Below by embodiment, the present invention will be further described.In the present invention, if not refering in particular to, Suo Youbai Point ratio is unit of weight, and all devices and raw material are commercially available or the industry is commonly used, in following embodiments Method, it is this area conventional method unless otherwise instructed.
Embodiment 1
A kind of root of Chinese clematis expelling wind and clearing away cold dip, is made up of the herbal raw material of following each component：The root of Chinese clematis, tetrandra root, cortex acanthopanacis, Notopterygium root, levisticum, Ligusticum wallichii, the radix paeoniae rubrathe, safflower, rhizoma homalonemae, reticulate millettia, caulis piperis futokadsurae and caulis sinomenii.The tool of each component in herbal raw material Body proportioning is as shown in table 1.
The preparation method of root of Chinese clematis expelling wind and clearing away cold dip of the present invention, comprises the following steps：
（1）Stock：The impurity in herbal raw material is rejected, goes mouldy with after infested raw material, is stocked up according to aforementioned proportion；
（2）Feedstock treating：Herbal raw material is cleaned up, at 72 DEG C, after air blast drying, pulverizer crushes, and crosses 50 mesh Sieve, mix, obtain composite Chinese herbal raw material；
（3）Enzymolysis：By step（2）Gained composite Chinese herbal raw material adds water to solid-to-liquid ratio 1：4, by 1.5 g/L, 1.3 g/L, 1.6 G/L ratios add non-starch polysaccharide enzyme, carbohydrase, cellulase respectively, under the effect of 700 W ultrasonic assistants, in 42 DEG C of bars The min of coordinated enzymatic hydrolysis 45 under part；
（4）Microbial fermentation：To step（3）The Bifidobacterium added in gained Enzymolysis liquid after 5% activation（Viable count >=200 Hundred million/ml）, ferment under anaerobic condition 13 h, controls 32 DEG C of fermentation temperature；
（5）Ultrasonic assistant flooding：By step（4）Microbial fermentation mixed liquor, 85 DEG C are warmed to, it is auxiliary in 750 W ultrasonic waves Help under effect, extract 65 min, after extraction terminates, cross 180 mesh filter clothes and obtain water extract.Filter residue adds 4 times of pure water, by same sample prescription Method carries out Ultrasonic Wave-Assisted Extraction, filters to get filtrate, and it is water extract to merge extract solution twice；
（6）Ultrasonic assistant alcohol steep：To step（5）The ethanol that 5 times of concentration are 60% is added in gained filter residue, in 650 W Under the conditions of ultrasonic assistant, 45 min, 65 DEG C of extraction temperature are extracted；
（7）Centrifugation：Extraction centrifuges solid residue and alcohol extract after terminating；
（8）Concentration distillation：Alcohol extract is concentrated under reduced pressure and is distilled to recover ethanol；
（9）Mixing：By step（5）Water extract and step（8）Reclaim the leaching liquor mixing after ethanol；
（10）Filtering：Mixed liquor is filtered to remove impurity and insoluble matter therein through diatom filter and produces root of Chinese clematis expelling wind and clearing away cold Dip.
Embodiment 2
A kind of root of Chinese clematis expelling wind and clearing away cold dip, is made up of the herbal raw material of following each component：The root of Chinese clematis, tetrandra root, cortex acanthopanacis, Notopterygium root, levisticum, Ligusticum wallichii, the radix paeoniae rubrathe, safflower, rhizoma homalonemae, reticulate millettia, caulis piperis futokadsurae and caulis sinomenii.The tool of each component in herbal raw material Body proportioning is as shown in table 1.
The preparation method of root of Chinese clematis expelling wind and clearing away cold dip of the present invention, comprises the following steps：
（1）Stock：The impurity in herbal raw material is rejected, goes mouldy with after infested raw material, is stocked up according to aforementioned proportion；
（2）Feedstock treating：Herbal raw material is cleaned up, at 67 DEG C, after air blast drying, pulverizer crushes, and crosses 60 mesh Sieve, mix, obtain composite Chinese herbal raw material；
（3）Enzymolysis：By step（2）Gained composite Chinese herbal raw material adds water to solid-to-liquid ratio 1：3, by 1.8 g/L, 1.1 g/L, 1.6 G/L ratios add non-starch polysaccharide enzyme, carbohydrase, cellulase respectively, under the effect of 800 W ultrasonic assistants, in 45 DEG C of bars The min of coordinated enzymatic hydrolysis 50 under part；
（4）Microbial fermentation：To step（3）The Bifidobacterium added in gained Enzymolysis liquid after 4% activation（Viable count >=200 Hundred million/ml）, ferment under anaerobic condition 14 h, controls 35 DEG C of fermentation temperature；
（5）Ultrasonic assistant flooding：By step（4）Microbial fermentation mixed liquor, 82 DEG C are warmed to, it is auxiliary in 700 W ultrasonic waves Help under effect, extract 70 min, after extraction terminates, cross 160 mesh filter clothes and obtain water extract.Filter residue adds 3 times of pure water, by same sample prescription Method carries out Ultrasonic Wave-Assisted Extraction, filters to get filtrate, and it is water extract to merge extract solution twice；
（6）Ultrasonic assistant alcohol steep：To step（5）The ethanol that 6 times of concentration are 63% is added in gained filter residue, is surpassed in 700 W Under sound wave subsidiary conditions, 50 min, 70 DEG C of extraction temperature are extracted；
（7）Centrifugation：Extraction centrifuges solid residue and alcohol extract after terminating；
（8）Concentration distillation：Alcohol extract is concentrated under reduced pressure and is distilled to recover ethanol；
（9）Mixing：By step（5）Water extract and step（8）Reclaim the leaching liquor mixing after ethanol；
（10）Filtering：Mixed liquor is filtered to remove impurity and insoluble matter therein through diatom filter and produces root of Chinese clematis expelling wind and clearing away cold Dip.
Embodiment 3
A kind of root of Chinese clematis expelling wind and clearing away cold dip, is made up of the herbal raw material of following each component：The root of Chinese clematis, tetrandra root, cortex acanthopanacis, Notopterygium root, levisticum, Ligusticum wallichii, the radix paeoniae rubrathe, safflower, rhizoma homalonemae, reticulate millettia, caulis piperis futokadsurae and caulis sinomenii.The tool of each component in herbal raw material Body proportioning is as shown in table 1.
The preparation method of root of Chinese clematis expelling wind and clearing away cold dip of the present invention, comprises the following steps：
（1）Stock：The impurity in herbal raw material is rejected, goes mouldy with after infested raw material, is stocked up according to aforementioned proportion；
（2）Feedstock treating：Herbal raw material is cleaned up, at 62 DEG C, after air blast drying, pulverizer crushes, and crosses 70 mesh Sieve, mix, obtain composite Chinese herbal raw material；
（3）Enzymolysis：By step（2）Gained composite Chinese herbal raw material adds water to solid-to-liquid ratio 1：5, by 1.2 g/L, 0.9 g/L, 2.4 G/L ratios add non-starch polysaccharide enzyme, carbohydrase, cellulase respectively, under the effect of 900 W ultrasonic assistants, in 48 DEG C of bars The min of coordinated enzymatic hydrolysis 55 under part；
（4）Microbial fermentation：To step（3）The Bifidobacterium added in gained Enzymolysis liquid after 3% activation（Viable count >=200 Hundred million/ml）, ferment under anaerobic condition 12 h, controls 30 DEG C of fermentation temperature；
（5）Ultrasonic assistant flooding：By step（4）Microbial fermentation mixed liquor, 88 DEG C are warmed to, it is auxiliary in 650 W ultrasonic waves Help under effect, extract 75 min, after extraction terminates, cross 200 mesh filter clothes and obtain water extract.Filter residue adds 5 times of pure water, by same sample prescription Method carries out Ultrasonic Wave-Assisted Extraction, filters to get filtrate, and it is water extract to merge extract solution twice；
（6）Ultrasonic assistant alcohol steep：To step（5）The ethanol that 4 times of concentration are 58% is added in gained filter residue, in 750 W Under the conditions of ultrasonic assistant, 55 min, 75 DEG C of extraction temperature are extracted；
（7）Centrifugation：Extraction centrifuges solid residue and alcohol extract after terminating；
（8）Concentration distillation：Alcohol extract is concentrated under reduced pressure and is distilled to recover ethanol；
（9）Mixing：By step（5）Water extract and step（8）Reclaim the leaching liquor mixing after ethanol；
（10）Filtering：Mixed liquor is filtered to remove impurity and insoluble matter therein through diatom filter and produces root of Chinese clematis expelling wind and clearing away cold Dip.
The composition and ratio of each embodiment herbal raw material of table 1.
Sequence number Component Embodiment 1 Embodiment 2 Embodiment 3
1 The root of Chinese clematis（Part） 29 26 23
2 The root of fangji（Part） 17 19 16
3 Cortex acanthopanacis（Part） 13 17 19
4 Notopterygium root（Part） 7 9 5
5 Levisticum（Part） 12 14 11
6 Ligusticum wallichii（Part） 6 5 7
7 The radix paeoniae rubrathe（Part） 6 7 9
8 Safflower（Part） 5 4 3
9 Rhizoma homalonemae（Part） 14 16 18
10 Reticulate millettia（Part） 8 7 6
11 Caulis piperis futokadsurae（Part） 12 13 15
12 Caulis sinomenii（Part） 14 11 13
13 Summation（Part） 143 148 145
Although to reach illustration purpose, described above is the preferred embodiments of the present invention, is not intended to limit the invention, to the greatest extent The present invention is described in detail with reference to the foregoing embodiments for pipe, and for those skilled in the art, it still can be with The technical scheme recorded to foregoing embodiments is modified, or carries out equivalent substitution to which part technical characteristic.It is all Within the spirit and principles in the present invention, any modification, equivalent substitution and improvements made etc., the protection of the present invention should be included in Within the scope of.

Claims (2)

1. a kind of root of Chinese clematis expelling wind and clearing away cold dip, it is characterised in that be made up of following herbal raw material by weight：Wheeling 20~30 parts of celestial being, 15~20 parts of tetrandra root, 10~20 parts of cortex acanthopanacis, 5~10 parts of notopterygium root, 10~15 parts of levisticum, 4~8 parts of Ligusticum wallichii are red 5~10 parts of Chinese herbaceous peony, 3~6 parts of safflower, 10~20 parts of rhizoma homalonemae, 5~10 parts of reticulate millettia, 10~15 parts of caulis piperis futokadsurae and caulis sinomenii 10~ 15 parts.
2. a kind of preparation method of root of Chinese clematis expelling wind and clearing away cold dip as claimed in claim 1, it is characterised in that including following Step：
（1）Stock：The impurity in herbal raw material is rejected, goes mouldy with after infested raw material, is stocked up according to aforementioned proportion；
（2）Feedstock treating：Herbal raw material is cleaned up, at 60~75 DEG C, after air blast drying, pulverizer crushes, and crosses 40 ~80 mesh sieves, mix, obtain composite Chinese herbal raw material；
（3）Enzymolysis：By step（2）Gained composite Chinese herbal raw material adds water to solid-to-liquid ratio 1：3~5, by 1.0~2.0 g/L, 0.8 ~1.5 g/L, 1.5~2.5 g/L ratios add non-starch polysaccharide enzyme, carbohydrase, cellulase respectively, surpass in 600 ~ 1000 W Under sound wave booster action, the min of coordinated enzymatic hydrolysis 40~60 under the conditions of 40~50 DEG C；
（4）Microbial fermentation：To step（3）The Bifidobacterium added in gained Enzymolysis liquid after 3~5% activation（Viable count >= 20000000000/ml）, ferment under anaerobic condition 12~15 h, controls 30~35 DEG C of fermentation temperature；
（5）Ultrasonic assistant flooding：By step（4）Microbial fermentation mixed liquor, 80~90 DEG C are warmed to, in 600 ~ 800 W Under ultrasonic assistant effect, 60 ~ 75 min are extracted, after extraction terminates, 150 ~ 200 mesh filter clothes is crossed and obtains water extract；Filter residue adds 3 ~ 5 Times pure water, carries out Ultrasonic Wave-Assisted Extraction, filters to get filtrate in the same way, and it is water extract to merge extract solution twice；
（6）Ultrasonic assistant alcohol steep：To step（5）The ethanol that 3~6 times of concentration are 55~65% is added in gained filter residue, Under the conditions of 600~800 W ultrasonic assistants, 40~60 min, 60~75 DEG C of extraction temperature are extracted；
（7）Centrifugation：Extraction centrifuges solid residue and alcohol extract after terminating；
（8）Concentration distillation：Alcohol extract is concentrated under reduced pressure and is distilled to recover ethanol；
（9）Mixing：By step（5）Water extract and step（8）Reclaim the leaching liquor mixing after ethanol；
（10）Filtering：Mixed liquor is filtered to remove impurity and insoluble matter therein through diatom filter and produces root of Chinese clematis expelling wind and clearing away cold Dip.
CN201710727825.7A 2017-08-23 2017-08-23 A kind of root of Chinese clematis expelling wind and clearing away cold dip and preparation method thereof Pending CN107441272A (en)

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Application publication date: 20171208