CN107929448A - Relaxing tendons and activating collaterals, the Chinese medicine of dispelling fatigue is promoted to foam foot prescription and preparation method thereof - Google Patents
Relaxing tendons and activating collaterals, the Chinese medicine of dispelling fatigue is promoted to foam foot prescription and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to field of traditional Chinese, and more particularly to relaxing tendons and activating collaterals, the Chinese medicine of dispelling fatigue is promoted to foam foot prescription and preparation method thereof;It includes preparing medicinal raw material, prepares extract and fermentation, and medicinal raw material includes the safflower of 0.5 2 parts by weight, the Angelica sinensis of 10 20 parts by weight, the bush of 5 15 parts by weight, the Herba Lycopi of 5 15 parts by weight, the dried rhizome of rehmannia, the cassia twig of 5 15 parts by weight of 5 15 parts by weight;The preparation method can fully extract the active ingredient in medicinal raw material, to reduce the input of raw material;The prescription agent can promote absorption of the human body to medicine, and then can improve drug effect.
Description
Technical field
The present invention relates to field of traditional Chinese, and more particularly to relaxing tendons and activating collaterals, the Chinese medicine of dispelling fatigue is promoted to foam foot prescription
And preparation method thereof.
Background technology
Bubble foot (pedicure) can loosen the channels and collaterals on foot and at shank by heating power, accelerate blood circulation, improve the heart
The blood supply of the organs such as brain, and being continuously increased with heating power, human body will start to perspire slightly, can reach the work of dredging the channel
With cold air and waste in discharge human body, adjust the body temperature drop fire of deficiency type, and sanguimotor improvement, have clearly to blood pressure
Bidirectional modulation effect.But only by hot water reach relaxing tendons and activating collaterals, dispelling fatigue effect it is limited, existing some pedicures
Although medicament can improve relaxing tendons and activating collaterals, the effect of dispelling fatigue to a certain extent, effect improved limited, drug effect cannot
Give full play to, be more difficult to play drug effect longer.
The content of the invention
It is an object of the invention to provide a kind of Chinese medicine for promoting relaxing tendons and activating collaterals, dispelling fatigue to foam foot prescription, the medicament energy
Absorbability of the patient to effective ingredient is enough improved, and then improves drug effect, user's passages through which vital energy circulates is dredged, refreshes the mind, is reduced
Sense tired out etc..
Another object of the present invention is to provide a kind of Chinese medicine for promoting relaxing tendons and activating collaterals, dispelling fatigue to foam foot the preparation of prescription
Method, the preparation method can fully extract the active ingredient in medicinal raw material, to reduce the input of raw material;And should
Preparation method can improve absorption of the human body to medicine, and then can improve passages through which vital energy circulates dredging, refresh the mind, and reduce sense tired out etc. and make
With.
The present invention is realized using following technical scheme.
The present invention proposes that a kind of promotion relaxing tendons and activating collaterals, the Chinese medicine of dispelling fatigue foam foot prescription, its medicinal raw material includes:0.5-
The safflower of 2 parts by weight, the Angelica sinensis of 10-20 parts by weight, the bush of 5-15 parts by weight, the Herba Lycopi of 5-15 parts by weight, 5-15 weight
The dried rhizome of rehmannia, the cassia twig of 5-15 parts by weight of part.
The present invention proposes a kind of preparation method for promoting relaxing tendons and activating collaterals, the Chinese medicine of dispelling fatigue to foam foot prescription, including prepares
Medicinal raw material, prepare extract and fermentation.
Wherein, medicinal raw material includes:The safflower of 0.5-2 parts by weight, the Angelica sinensis of 10-20 parts by weight, 5-15 parts by weight
Bush, the Herba Lycopi of 5-15 parts by weight, the dried rhizome of rehmannia of 5-15 parts by weight, the cassia twig of 5-15 parts by weight.
Preparing extract includes adding water to cook in the powder of medicinal raw material, and the first extracting solution and the first medicine are obtained after filtering
Slag, first dregs of a decoction alcohol reflux of 30-50vol% is extracted, obtains the second extracting solution and second dregs of a decoction.
Fermentation includes:It is concentrated in vacuo after first extracting solution and the second extracting solution are mixed, it is 1.05- to obtain relative density
1.1 clear cream;Saccharomycete is added in clear cream, is subsequently placed under the conditions of temperature is 25-30 DEG C and ferments, then sterilization treatment, obtain
First fermentation liquid;Second dregs of a decoction are placed under the conditions of temperature is 30-35 DEG C and are fermented, decoction is added water and filters, obtain second
Ferment liquid;The fermentation liquid of mixing first and the second fermentation liquid.
The promotion relaxing tendons and activating collaterals of the embodiment of the present invention, the Chinese medicine of dispelling fatigue foam foot the beneficial effect of prescription and preparation method thereof
Fruit is:The preparation method can fully extract the active ingredient in medicinal raw material, to reduce the input of raw material;And by
Prescription agent prepared by the preparation method can promote absorption of the human body to medicine, and then can improve drug effect, dredging user's warp
Arteries and veins, refreshes the mind, and reduces sense tired out etc..
Embodiment
, below will be in the embodiment of the present invention to make the purpose, technical scheme and advantage of the embodiment of the present invention clearer
Technical solution be clearly and completely described.The person that is not specified actual conditions in embodiment, builds according to normal condition or manufacturer
The condition of view carries out.Reagents or instruments used without specified manufacturer, is the conventional production that can be obtained by commercially available purchase
Product.
Promotion relaxing tendons and activating collaterals to the embodiment of the present invention below, the Chinese medicine of dispelling fatigue foam foot prescription and preparation method thereof into
Row illustrates.
The medicinal raw material that the promotion relaxing tendons and activating collaterals of the present invention, the Chinese medicine of dispelling fatigue foam foot prescription includes:0.5-2 parts by weight
Safflower, the Angelica sinensis of 10-20 parts by weight, the bush of 5-15 parts by weight, 5-15 parts by weight Herba Lycopi, 5-15 parts by weight life
The cassia twig on ground, 5-15 parts by weight.
Preferably, above-mentioned medicinal raw material includes the safflower of 1 parts by weight, the Angelica sinensis of 15 parts by weight, the Soviet Union of 10 parts by weight
Wood, the Herba Lycopi of 10 parts by weight, the dried rhizome of rehmannia of 10 parts by weight, the cassia twig of 10 parts by weight.
Safflower, Angelica sinensis, bush, Herba Lycopi, the dried rhizome of rehmannia and cassia twig are respectively provided with calm, promoting blood circulation and removing blood stasis, benefiting blood and regulating blood circulation, analgesic, dissipate
The stasis of blood, promoting menstruation etc. act on.
The prescription agent prepared by above-mentioned medicinal raw material, can dredge the passages through which vital energy circulates of user, promote the blood circulation of user,
Promote discharge of cold air and waste in body etc., additionally it is possible to improve the blood supply of user's heart and brain, eliminate the tired out of user
Sense, lifting restoring consciouness etc..
The preparation method that the promotion relaxing tendons and activating collaterals, the Chinese medicine of dispelling fatigue foam foot prescription includes preparing medicinal raw material, prepares
Extract and fermentation.
In detail, after preparing raw material according to the parts by weight of above-mentioned medicinal raw material, the powder of medicinal raw material is added water to cook,
The first extracting solution and first dregs of a decoction are obtained after filtering, first dregs of a decoction alcohol reflux of 30-50vol% is extracted, obtains second
Extracting solution and second dregs of a decoction.
The particle diameter of above-mentioned medicinal raw material powder can be 300-500 mesh, and can be each medicinal powder directly bought
Stock up according to required parts by weight;It can also be after being stocked up with the medicinal powder not being milled according to required parts by weight, return
Milling processing is carried out before stream extraction.
The weight ratio of above-mentioned medicinal raw material and 30-50vol% ethanol is 1:5-10, the temperature of refluxing extraction can be 30-
50 DEG C, the time of extraction can be 2-3h.According to the method described above carry out refluxing extraction can improve in first dregs of a decoction it is effective into
The it is proposed amount divided.
The time that medicinal raw material adds water to cook can be 1-3h, and can also further be surpassed while decocting
Sonication, supersonic frequency can be 20-30KHz.The water added in medicinal raw material can be 3-5 times of medicinal raw material weight.
Foregoing fermentation includes:It is concentrated in vacuo, is obtained relatively close after first extracting solution and the second extracting solution are mixed
Spend for the clear cream of 1.05-1.1 (35 DEG C), saccharomycete added in clear cream, be subsequently placed in temperature to ferment under the conditions of 25-30 DEG C,
Sterilization treatment again, obtains the first fermentation liquid;Second dregs of a decoction are placed under the conditions of temperature is 30-35 DEG C and are fermented, add water decoction
And filter, obtain the second fermentation liquid;The fermentation liquid of mixing first and the second fermentation liquid.
It should be noted that above-mentioned vacuum drying can be -0.01MPa~-0.02MPa, temperature 40- in vacuum pressure
Carried out under the conditions of 50 DEG C;Above-mentioned sterilizing can with Technology of Ultra-high Pressure Sterilization of the prior art, cold sterilization, pasteurization,
Ultrahigh-temperature instant sterilization or microwave disinfection etc..
Further, the concentration of saccharomycete can be 1 × 10 in above-mentioned clear cream4-105CFU/g.Yeast is added in clear cream
Bacterium is fermented, and can improve the ability that obtained prescription agent is absorbed by the body, and then improve the effect for the treatment of.Above-mentioned clear cream hair
The time of ferment can be 24-48h.It should be noted that the saccharomycete of addition can be according to microorganism with commercially available saccharomycete
Saccharomycete after common various prior arts activation or it is autonomous after purification, active saccharomycete.
The fermentation time of second dregs of a decoction can be 36-72h, and second dregs of a decoction are fermented a period of time at a higher temperature
Afterwards, decocting again further can extract the active ingredient in medicinal material, you can further to improve obtained medicine
The drug effect of prescription, improves therapeutic effect.When second dregs of a decoction after fermentation decoct, the water of addition is the 1-2 of the second dregs of a decoction weight
Times, the time of decoction can be 30-60min.
First fermentation liquid and second fermentation liquid mixing after, the liquid of mixing can be further made pulvis,
Granule, aqua or paste, such as:Pulvis is made in admixing medical solutions spray drying;Paste is made in admixing medical solutions concentration;Directly
Aqua is made in admixing medical solutions;Admixing medical solutions concentration postcooling is granulated granule etc. is made.
It should be noted that each parts by weight of above-mentioned medicinal raw material are identical, such as:Each parts by weight for 1kg,
1g etc..
The promotion relaxing tendons and activating collaterals to the present invention, the Chinese medicine of dispelling fatigue foam foot prescription and its preparation side with reference to embodiments
Method is described in further detail.
Embodiment 1
Prepare medicinal raw material, including:The safflower of 0.5 parts by weight, the Angelica sinensis of 20 parts by weight, the bush of 15 parts by weight, 5 weights
Measure the Herba Lycopi of part, the dried rhizome of rehmannia of 15 parts by weight, the cassia twig of 5 parts by weight.
The powder of medicinal raw material is added water to cook into 1h (100 DEG C), the first extracting solution and first dregs of a decoction, medicinal material are obtained after filtering
The water added in raw material is 3 times of medicinal raw material weight;Flowed back and extracted to first dregs of a decoction with the ethanol of 30vol%;Wherein, medicinal material
The weight ratio of raw material and ethanol is 1:5, the temperature of refluxing extraction is 30 DEG C, time 3h;The second extraction is obtained after refluxing extraction
Liquid and second dregs of a decoction.
It is -0.01MPa that obtained first extracting solution and the second extracting solution are placed in vacuum pressure, under the conditions of temperature is 40 DEG C
It is concentrated in vacuo, obtains the clear cream that relative density is 1.05 (35 DEG C), add saccharomycete in obtained clear cream, be placed in 25 DEG C of conditions
Under, ferment 24h, then microwave disinfection, obtains the first fermentation liquid;The concentration of saccharomycete is 1 × 10 wherein in clear cream4CFU/g.Will
Second dregs of a decoction are placed under the conditions of temperature is 30 DEG C the 36h that ferments, then add the water of 1 times of amount of the second dregs of a decoction weight, decoct 30min, mistake
Filter, obtains the second fermentation liquid.
After first fermentation liquid and the second fermentation liquid are mixed, pulvis is made in spray drying, you can is promoted relaxing muscles and tendons
Promoting blood circulation, the Chinese medicine of dispelling fatigue foam foot prescription.
Embodiment 2
Prepare medicinal raw material, including:The safflower of 2 parts by weight, the Angelica sinensis of 10 parts by weight, the bush of 5 parts by weight, 15 weight
The Herba Lycopi of part, the dried rhizome of rehmannia, the cassia twig of 15 parts by weight of 5 parts by weight.
The powder of medicinal raw material is added water to cook into 3h (100 DEG C), the first extracting solution and first dregs of a decoction, medicinal material are obtained after filtering
The water added in raw material is 5 times of medicinal raw material weight;Flowed back and extracted to first dregs of a decoction with the ethanol of 50vol%;Wherein, medicinal material
The weight ratio of raw material and ethanol is 1:10, the temperature of refluxing extraction is 50 DEG C, time 2h;The second extraction is obtained after refluxing extraction
Liquid and second dregs of a decoction.
It is -0.02MPa that obtained first extracting solution and the second extracting solution are placed in vacuum pressure, under the conditions of temperature is 50 DEG C
It is concentrated in vacuo, obtains the clear cream that relative density is 1.1 (35 DEG C), add saccharomycete in obtained clear cream, be placed in 30 DEG C of conditions
Under, ferment 48h, then microwave disinfection, obtains the first fermentation liquid;The concentration of saccharomycete is 1 × 10 wherein in clear cream5CFU/g.Will
Second dregs of a decoction are placed under the conditions of temperature is 35 DEG C the 72h that ferments, then add the water of 2 times of amounts of the second dregs of a decoction weight, decoct 60min, mistake
Filter, obtains the second fermentation liquid.
By first fermentation liquid and second fermentation liquid mix after, concentration paste is made, you can be promoted relaxing tendons and activating collaterals,
The Chinese medicine of dispelling fatigue foams foot prescription.
Embodiment 3
Prepare medicinal raw material, including:The safflower of 1 parts by weight, the Angelica sinensis of 15 parts by weight, the bush of 10 parts by weight, 10 weights
Measure the Herba Lycopi of part, the dried rhizome of rehmannia of 10 parts by weight, the cassia twig of 10 parts by weight.
The powder (300 mesh) of medicinal raw material is added water to cook into 2h (97 DEG C), the first extracting solution and the first medicine are obtained after filtering
Slag, the water added in medicinal raw material are 4 times of medicinal raw material weight;Reflux leaching is carried out to first dregs of a decoction with the ethanol of 40vol%
Carry;Wherein, the weight ratio of medicinal raw material and ethanol is 1:7, the temperature of refluxing extraction is 40 DEG C, time 2.5h;Refluxing extraction
After obtain the second extracting solution and second dregs of a decoction.
It is -0.01MPa that obtained first extracting solution and the second extracting solution are placed in vacuum pressure, under the conditions of temperature is 45 DEG C
It is concentrated in vacuo, obtains the clear cream that relative density is 1.06 (35 DEG C), add saccharomycete in obtained clear cream, be placed in 27 DEG C of conditions
Under, ferment 36h, then microwave disinfection, obtains the first fermentation liquid;The concentration of saccharomycete is 8 × 10 wherein in clear cream4CFU/g.Will
Second dregs of a decoction are placed under the conditions of temperature is 31 DEG C the 50h that ferments, then add the water of 1.5 times of amounts of the second dregs of a decoction weight, decoct 40min,
Filtering, obtains the second fermentation liquid.
After first fermentation liquid and the second fermentation liquid are mixed, aqua is made, you can be promoted relaxing tendons and activating collaterals, eliminate
The Chinese medicine of fatigue foams foot prescription.
Embodiment 4
Prepare medicinal raw material, including:The safflower of 1.5 parts by weight, the Angelica sinensis of 12 parts by weight, the bush of 12 parts by weight, 8 weights
Measure the Herba Lycopi of part, the dried rhizome of rehmannia of 11 parts by weight, the cassia twig of 8 parts by weight.
The powder (500 mesh) of medicinal raw material is added water to cook into 1.5h (100 DEG C), the first extracting solution and first are obtained after filtering
The dregs of a decoction, the water added in medicinal raw material is 3.5 times of medicinal raw material weight, and medicinal raw material is carried out at ultrasound while decocting
Reason, supersonic frequency 20KHz;Reflux extraction is carried out to first dregs of a decoction with the ethanol of 45vol%;Wherein, medicinal raw material and ethanol
Weight ratio be 1:6, the temperature of refluxing extraction is 45 DEG C, time 2h;The second extracting solution and the second medicine are obtained after refluxing extraction
Slag.
It is -0.015MPa that obtained first extracting solution and the second extracting solution are placed in vacuum pressure, and temperature is 45 DEG C of conditions
Lower vacuum concentration, obtains the clear cream that relative density is 1.1 (35 DEG C), adds saccharomycete in obtained clear cream, be placed in 28 DEG C of bars
Under part, ferment 30h, then microwave disinfection, obtains the first fermentation liquid;The concentration of saccharomycete is 5 × 10 wherein in clear cream4CFU/g。
Second dregs of a decoction are placed under the conditions of temperature is 33 DEG C the 60h that ferments, then add the water of 1.2 times of amounts of the second dregs of a decoction weight, are decocted
35min, filtering, obtains the second fermentation liquid.
After first fermentation liquid and the second fermentation liquid are mixed, granule is made in concentration, cooling granulation, you can is promoted
Chinese medicine into relaxing tendons and activating collaterals, dispelling fatigue foams foot prescription.
Embodiment 5
Prepare medicinal raw material, including:The safflower of 0.8 parts by weight, the Angelica sinensis of 12 parts by weight, the bush of 8 parts by weight, 12 weights
Measure the Herba Lycopi of part, the dried rhizome of rehmannia of 12 parts by weight, the cassia twig of 11 parts by weight.
The powder (400 mesh) of medicinal raw material is added water to cook into 2.5h (99 DEG C), the first extracting solution and first are obtained after filtering
The dregs of a decoction, the water added in medicinal raw material is 4.5 times of medicinal raw material weight, and medicinal raw material is carried out at ultrasound while decocting
Reason, supersonic frequency 30KHz;Reflux extraction is carried out to first dregs of a decoction with the ethanol of 48vol%;Wherein, medicinal raw material and ethanol
Weight ratio be 1:7, the temperature of refluxing extraction is 42 DEG C, time 2.5h;The second extracting solution and second are obtained after refluxing extraction
The dregs of a decoction.
It is -0.02MPa that obtained first extracting solution and the second extracting solution are placed in vacuum pressure, under the conditions of temperature is 48 DEG C
It is concentrated in vacuo, obtains the clear cream that relative density is 1.05 (35 DEG C), add saccharomycete in obtained clear cream, be placed in 27 DEG C of conditions
Under, ferment 40h, then microwave disinfection, obtains the first fermentation liquid;The concentration of saccharomycete is 7 × 10 wherein in clear cream4CFU/g.Will
Second dregs of a decoction are placed under the conditions of temperature is 32 DEG C the 55h that ferments, then add the water of 1.6 times of amounts of the second dregs of a decoction weight, decoct 48min,
Filtering, obtains the second fermentation liquid.
After first fermentation liquid and the second fermentation liquid are mixed, granule is made in concentration, cooling granulation, you can is promoted
Chinese medicine into relaxing tendons and activating collaterals, dispelling fatigue foams foot prescription.
Embodiment 6
Prepare medicinal raw material, including:The safflower of 1.2 parts by weight, the Angelica sinensis of 16 parts by weight, the bush of 7 parts by weight, 11 weights
Measure the Herba Lycopi of part, the dried rhizome of rehmannia of 7 parts by weight, the cassia twig of 13 parts by weight.
The powder of medicinal raw material is added water to cook into 2h (97 DEG C), the first extracting solution and first dregs of a decoction, medicinal material are obtained after filtering
The water added in raw material is 3.2 times of medicinal raw material weight, and medicinal raw material is ultrasonically treated while decocting, supersonic frequency
Rate is 25KHz;Reflux extraction is carried out to first dregs of a decoction with the ethanol of 37vol%;Wherein, the weight ratio of medicinal raw material and ethanol is
1:9, the temperature of refluxing extraction is 36 DEG C, time 2h;The second extracting solution and second dregs of a decoction are obtained after refluxing extraction.
It is -0.01MPa that obtained first extracting solution and the second extracting solution are placed in vacuum pressure, under the conditions of temperature is 45 DEG C
It is concentrated in vacuo, obtains the clear cream that relative density is 1.05 (35 DEG C), add saccharomycete in obtained clear cream, be placed in 26 DEG C of conditions
Under, ferment 42h, then ultrahigh-temperature instant sterilization, obtains the first fermentation liquid;Wherein in clear cream the concentration of saccharomycete for 3 ×
104CFU/g.Second dregs of a decoction are placed under the conditions of temperature is 32 DEG C the 42h that ferments, then add the water of 1.8 times of amounts of the second dregs of a decoction weight,
55min is decocted, filtering, obtains the second fermentation liquid.
After first fermentation liquid and the second fermentation liquid are mixed, granule is made in concentration, cooling granulation, you can is promoted
Chinese medicine into relaxing tendons and activating collaterals, dispelling fatigue foams foot prescription.
Comparative example 1
The preparation method of comparative example 1 difference similar with the preparation method of embodiment 3 is, only medication in comparative example 1
Material raw material is decocted and is flowed back extraction, does not carry out the process after reflux extraction, and with decocting and the extracting solution of reflux extraction
It is prepared into pulvis, weight, species and the condition of reflux extraction of medicinal raw material etc. and refer to embodiment 3.
Comparative example 2
The preparation method and embodiment 3 of comparative example 2 are similar, and difference is, does not add in the medicinal raw material in comparative example 2
Add Herba Lycopi, remaining method and step is with reference to embodiment 3.
Comparative example 3
The preparation method and embodiment 3 of comparative example 3 are similar, and difference is, does not add in the medicinal raw material in comparative example 3
Add cassia twig, remaining method and step is with reference to embodiment 3.
Comparative example 4
The preparation method and embodiment 3 of comparative example 4 are similar, and difference is, does not add in the medicinal raw material in comparative example 4
Add Herba Lycopi and cassia twig, remaining method and step is with reference to embodiment 3.
Obtained prescription agent in embodiment 1-6 and comparative example 1-4 is used for experimental investigation, chooses age bracket at 30-35 Sui
100, the 40-45 Sui female patient 100 of female patient of male patient 100 and 30-35 Sui of male patient 100,40-45 Sui
Example, and the course of disease is 50-60d, performance symptom is insufficiency of vital energy and blood, and calf blood is not smooth, swelling, even pain, often dizzy,
Night dreaminess etc.;It is randomly assigned 10 test groups again, 10,40-45 Sui male patient 10 of every group of 30-35 Sui male patient,
10,40-45 Sui female patient 10 of 30-35 Sui female patient.
It you can well imagine the prescription agent for embodiment 1-6 and comparative example 1-4 per component, every group of every night is with the prescriptions of 30g each groups
1L bubble foot 30min are added in agent, and 7d is as a treatment course, after a course for the treatment of, investigates whether the corresponding illness of each respondent has
Alleviated, criterion is as follows:
Recovery from illness:Shank swelling disappearance, dizziness are obviously improved, sleep quality improves;It is effective:Shank swelling has disappeared, head
Dizzy to make moderate progress, sleep quality has certain improvement;It is invalid:Shank swelling does not disappear, dizziness does not improve, and sleep quality does not improve
Deng.It the results are shown in Table 1.
The effect of 1 each group prescription agent of table be'ss to respondent result (number)
According to the comparing result of comparative example 1 and embodiment 1-5, carried out in preparation method of the invention first extraction
The fermentation of liquid and the second extracting solution and the fermentation of the dregs of a decoction etc., can provide out drug effect higher, the prescription agent for promoting sufferer to absorb for oneself,
Promote giving full play to for medicinal raw material drug effect.
According to the comparing result of comparative example 2-4 and embodiment 1-6, the formula in preparation method of the invention can have
Improvement calf blood in effect ground is not smooth, swelling, even pain, often the symptom such as dizziness, night dreaminess, is added in being particularly formulated
After Herba Lycopi and cassia twig, it can significantly play and improve prescription agent therapeutic effect.
In conclusion the promotion relaxing tendons and activating collaterals of the embodiment of the present invention, the Chinese medicine of dispelling fatigue foam foot prescription and its preparation side
The beneficial effect of method is:Preparation method can fully extract the active ingredient in medicinal raw material, to reduce raw material
Input;And the prescription agent prepared by the preparation method can promote absorption of the human body to medicine, and then drug effect can be improved, dredged
User's passages through which vital energy circulates, refreshes the mind, and reduces sense tired out etc..
Embodiments described above is part of the embodiment of the present invention, instead of all the embodiments.The reality of the present invention
The detailed description for applying example is not intended to limit the scope of claimed invention, but is merely representative of the selected implementation of the present invention
Example.Based on the embodiments of the present invention, those of ordinary skill in the art are obtained without creative efforts
Every other embodiment, belongs to the scope of protection of the invention.
Claims (10)
1. a kind of promotion relaxing tendons and activating collaterals, the Chinese medicine of dispelling fatigue foam foot prescription, it is characterised in that its medicinal raw material includes:0.5-2
The safflower of parts by weight, the Angelica sinensis of 10-20 parts by weight, the bush of 5-15 parts by weight, the Herba Lycopi of 5-15 parts by weight, 5-15 parts by weight
The dried rhizome of rehmannia, the cassia twig of 5-15 parts by weight.
2. promotion relaxing tendons and activating collaterals according to claim 1, the Chinese medicine of dispelling fatigue foam foot prescription, it is characterised in that described
Medicinal raw material includes:The safflower of 1 parts by weight, the Angelica sinensis of 15 parts by weight, the bush of 10 parts by weight, 10 weight
The Herba Lycopi of part, the dried rhizome of rehmannia, the cassia twig of 10 parts by weight of 10 parts by weight.
3. a kind of preparation method for promoting relaxing tendons and activating collaterals, the Chinese medicine of dispelling fatigue to foam foot prescription, it is characterised in that including preparing medicine
Material raw material, prepare extract and fermentation, wherein,
The medicinal raw material includes:The safflower of 0.5-2 parts by weight, the Angelica sinensis of 10-20 parts by weight, 5-15 parts by weight bush,
The Herba Lycopi of 5-15 parts by weight, the dried rhizome of rehmannia of 5-15 parts by weight, the cassia twig of 5-15 parts by weight;
The extract for preparing includes adding water to cook in the powder of the medicinal raw material, and the first extracting solution and first are obtained after filtering
The dregs of a decoction, first dregs of a decoction alcohol reflux of 30-50vol% is extracted, obtains the second extracting solution and second dregs of a decoction;
The fermentation includes:It is concentrated in vacuo after first extracting solution and second extracting solution are mixed, obtains relative density
For the clear cream of 1.05-1.1;Saccharomycete is added in the clear cream, is subsequently placed under the conditions of temperature is 25-30 DEG C and ferments, then go out
Bacterium is handled, and obtains the first fermentation liquid;Second dregs of a decoction are placed under the conditions of temperature is 30-35 DEG C and are fermented, add water decoction
And filter, obtain the second fermentation liquid;Mix the first fermentation liquid and the second fermentation liquid.
4. the preparation method according to claim 3 for promoting relaxing tendons and activating collaterals, the Chinese medicine of dispelling fatigue to foam foot prescription, its feature
It is, the weight ratio of the medicinal raw material and the ethanol of the 30-50vol% is 1:5-10.
5. the preparation method according to claim 3 for promoting relaxing tendons and activating collaterals, the Chinese medicine of dispelling fatigue to foam foot prescription, its feature
It is, the temperature of the refluxing extraction is 30-50 DEG C, time 2-3h.
6. the preparation method according to claim 3 for promoting relaxing tendons and activating collaterals, the Chinese medicine of dispelling fatigue to foam foot prescription, its feature
It is, the concentration of the saccharomycete in the clear cream is 1 × 104-105CFU/g。
7. the preparation method according to claim 3 for promoting relaxing tendons and activating collaterals, the Chinese medicine of dispelling fatigue to foam foot prescription, its feature
It is, the fermentation time of the clear cream is 24-48h.
8. the preparation method according to claim 3 for promoting relaxing tendons and activating collaterals, the Chinese medicine of dispelling fatigue to foam foot prescription, its feature
It is, the time of second dregs of a decoction fermentation is 36-72h.
9. the preparation method according to claim 3 for promoting relaxing tendons and activating collaterals, the Chinese medicine of dispelling fatigue to foam foot prescription, its feature
It is, the time that the medicinal raw material adds water to cook is 1-3h.
10. the preparation method according to claim 3 for promoting relaxing tendons and activating collaterals, the Chinese medicine of dispelling fatigue to foam foot prescription, it is special
Sign is, pulvis, granule, aqua or paste is made after the described first fermentation liquid and the second fermentation liquid are mixed.
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---|---|---|---|---|
CN110302241A (en) * | 2019-07-23 | 2019-10-08 | 永瑞植物科技(盐城)有限公司 | A kind of Novel feet-treating packet |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105878635A (en) * | 2014-12-12 | 2016-08-24 | 天津中新药业集团股份有限公司隆顺榕制药厂 | Traditional Chinese medicinal composition with efficacies of relaxing muscles and stimulating blood circulation and preparation method of traditional Chinese medicinal composition |
CN105878512A (en) * | 2014-10-22 | 2016-08-24 | 郑州爱博尔医疗设备有限公司 | Production method of a set of foot bath lotions aiming at conditioning subdivided constitutions |
CN106728327A (en) * | 2016-12-20 | 2017-05-31 | 余小军 | A kind of health-care foot-soaking prescription and preparation method thereof |
-
2017
- 2017-12-25 CN CN201711426047.4A patent/CN107929448A/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105878512A (en) * | 2014-10-22 | 2016-08-24 | 郑州爱博尔医疗设备有限公司 | Production method of a set of foot bath lotions aiming at conditioning subdivided constitutions |
CN105878635A (en) * | 2014-12-12 | 2016-08-24 | 天津中新药业集团股份有限公司隆顺榕制药厂 | Traditional Chinese medicinal composition with efficacies of relaxing muscles and stimulating blood circulation and preparation method of traditional Chinese medicinal composition |
CN106728327A (en) * | 2016-12-20 | 2017-05-31 | 余小军 | A kind of health-care foot-soaking prescription and preparation method thereof |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110302241A (en) * | 2019-07-23 | 2019-10-08 | 永瑞植物科技(盐城)有限公司 | A kind of Novel feet-treating packet |
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