CN107998204A - Treat Chinese medicine pedicure prescription agent of the ringworm of the foot, tinea pedis, foot odour, itch and preparation method thereof - Google Patents
Treat Chinese medicine pedicure prescription agent of the ringworm of the foot, tinea pedis, foot odour, itch and preparation method thereof Download PDFInfo
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- CN107998204A CN107998204A CN201711426000.8A CN201711426000A CN107998204A CN 107998204 A CN107998204 A CN 107998204A CN 201711426000 A CN201711426000 A CN 201711426000A CN 107998204 A CN107998204 A CN 107998204A
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- 210000002683 foot Anatomy 0.000 title claims abstract description 76
- 239000003814 drug Substances 0.000 title claims abstract description 49
- 239000003795 chemical substances by application Substances 0.000 title claims abstract description 43
- 208000003251 Pruritus Diseases 0.000 title claims abstract description 38
- 201000004647 tinea pedis Diseases 0.000 title claims abstract description 37
- 238000002360 preparation method Methods 0.000 title claims abstract description 36
- 208000002474 Tinea Diseases 0.000 title claims abstract description 34
- 241000893966 Trichophyton verrucosum Species 0.000 title claims abstract description 34
- 239000002994 raw material Substances 0.000 claims abstract description 56
- 238000000855 fermentation Methods 0.000 claims abstract description 53
- 230000004151 fermentation Effects 0.000 claims abstract description 53
- 241000218682 Pseudolarix amabilis Species 0.000 claims abstract description 20
- 244000246386 Mentha pulegium Species 0.000 claims abstract description 19
- 235000016257 Mentha pulegium Nutrition 0.000 claims abstract description 19
- 235000004357 Mentha x piperita Nutrition 0.000 claims abstract description 19
- 235000001050 hortel pimenta Nutrition 0.000 claims abstract description 19
- 241001251949 Xanthium sibiricum Species 0.000 claims abstract description 16
- 241001645380 Bassia scoparia Species 0.000 claims abstract description 15
- 235000004256 Buglossoides arvense Nutrition 0.000 claims abstract description 15
- 241000118841 Lithospermum incisum Species 0.000 claims abstract description 15
- 244000089698 Zanthoxylum simulans Species 0.000 claims abstract description 15
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 15
- 240000004980 Rheum officinale Species 0.000 claims abstract description 14
- 235000008081 Rheum officinale Nutrition 0.000 claims abstract description 14
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 44
- 239000007788 liquid Substances 0.000 claims description 43
- 239000006071 cream Substances 0.000 claims description 30
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 28
- 238000000605 extraction Methods 0.000 claims description 28
- 238000010992 reflux Methods 0.000 claims description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 28
- 241000894006 Bacteria Species 0.000 claims description 22
- 235000014655 lactic acid Nutrition 0.000 claims description 22
- 239000004310 lactic acid Substances 0.000 claims description 22
- 239000000706 filtrate Substances 0.000 claims description 18
- 238000001914 filtration Methods 0.000 claims description 15
- 239000000843 powder Substances 0.000 claims description 12
- 238000004659 sterilization and disinfection Methods 0.000 claims description 12
- 230000001954 sterilising effect Effects 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 abstract description 5
- 230000000857 drug effect Effects 0.000 abstract description 5
- 230000001976 improved effect Effects 0.000 abstract description 3
- 239000004615 ingredient Substances 0.000 abstract description 2
- 230000000052 comparative effect Effects 0.000 description 25
- 239000000243 solution Substances 0.000 description 19
- 230000000694 effects Effects 0.000 description 10
- 238000000034 method Methods 0.000 description 9
- 239000002893 slag Substances 0.000 description 8
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- 230000001225 therapeutic effect Effects 0.000 description 2
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- 201000004624 Dermatitis Diseases 0.000 description 1
- 208000002655 Foot Dermatoses Diseases 0.000 description 1
- 102000011782 Keratins Human genes 0.000 description 1
- 108010076876 Keratins Proteins 0.000 description 1
- 101000654738 Rattus norvegicus Septin-4 Proteins 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
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- 210000000106 sweat gland Anatomy 0.000 description 1
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/75—Rutaceae (Rue family)
- A61K36/758—Zanthoxylum, e.g. pricklyash
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/13—Coniferophyta (gymnosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract
The present invention relates to field of traditional Chinese, and more particularly to treat Chinese medicine pedicure prescription agent of the ringworm of the foot, tinea pedis, foot odour, itch and preparation method thereof；It includes preparing medicinal raw material, prepares extract and fermentation；Medicinal raw material includes the kuh-seng of 5 10 parts by weight, the Asian puccoon of 5 10 parts by weight, the folium artemisiae argyi of 2 10 parts by weight, the Chinese prickly ash of 58 parts by weight, the rheum officinale of 5 10 parts by weight, the fruit of summer cypress of 8 10 parts by weight, the Cortex Phellodendri of 15 20 parts by weight, the Golden Larch Bark of 15 parts by weight, the achene of Siberian cocklebur, the peppermint of 15 parts by weight of 15 parts by weight；The preparation method can fully extract the active ingredient in medicinal raw material, obtained prescription agent is improved absorbability of the patient to effective ingredient, and then improve drug effect, sufferer is more quickly cured.
Description
Technical field
The present invention relates to field of traditional Chinese, and more particularly to treat the ringworm of the foot, tinea pedis, foot odour, the Chinese medicine pedicure medicine of itch
Prescription and preparation method thereof.
Background technology
Tinea pedis is the foot dermatosis as caused by pathogenic fungus, has infectiousness.There is no sebum between the vola of people and toe
Gland, so as to lack the aliphatic acid for suppressing skin filamentous fungi, physiological defense function is poor, and the sweat gland of skin at these positions is very
It is abundant, perspire relatively more, air circulation is poor in addition, part damp warm, is conducive to the growth of filamentous fungi.In addition, vola
Area skin cuticula is thicker, and the keratin in cuticula is the abundant nutrition material of fungi, is conducive to the growth of fungi.Foot
The generation of fungi also results in the symptoms such as tinea pedis, foot odour and itch.Tinea pedis can treat, but in existing treatment medication, have
There is the patient festered not apply to serious tinea pedis, foot a bit, some can produce side effect etc. to patient, and lacking to be suitable for
The patient of various extents, and curative effect can be strengthened, and will not various patients be produced with the medicament of side effect.
The content of the invention
It is an object of the invention to provide a kind of Chinese medicine pedicure prescription agent for treating the ringworm of the foot, tinea pedis, foot odour, itch, the medicine
Agent can improve absorbability of the patient to effective ingredient, and then improve drug effect, sufferer is more quickly cured.
Another object of the present invention is to provide a kind of Chinese medicine pedicure prescription agent for treating the ringworm of the foot, tinea pedis, foot odour, itch
Preparation method, the preparation method can fully extract the active ingredient in medicinal raw material, to reduce the input of raw material；
And the preparation method can improve absorption of the human body to medicine, and then effect and cure rate for the treatment of etc. can be improved.
The present invention is realized using following technical scheme.
The present invention proposes a kind of Chinese medicine pedicure prescription agent for treating the ringworm of the foot, tinea pedis, foot odour, itch, its medicinal raw material includes：
The kuh-seng of 5-10 parts by weight, the Asian puccoon of 5-10 parts by weight, the folium artemisiae argyi of 2-10 parts by weight, the Chinese prickly ash of 5-8 parts by weight, 5-10 parts by weight
Rheum officinale, the fruit of summer cypress of 8-10 parts by weight, the Cortex Phellodendri of 15-20 parts by weight, the Golden Larch Bark of 1-5 parts by weight, the Siberian cocklebur of 1-5 parts by weight
Son, the peppermint of 1-5 parts by weight.
The present invention propose it is a kind of treat the ringworm of the foot, tinea pedis, foot odour, itch Chinese medicine pedicure prescription agent preparation method, including
Prepare medicinal raw material, prepare extract and fermentation.
Wherein, medicinal raw material includes：The kuh-seng of 5-10 parts by weight, the Asian puccoon of 5-10 parts by weight, 2-10 parts by weight folium artemisiae argyi,
The Chinese prickly ash of 5-8 parts by weight, the rheum officinale of 5-10 parts by weight, the fruit of summer cypress of 8-10 parts by weight, the Cortex Phellodendri of 15-20 parts by weight, 1-5 weight
The Golden Larch Bark of part, the achene of Siberian cocklebur, the peppermint of 1-5 parts by weight of 1-5 parts by weight.
Preparing extract includes extracting the powder of the medicinal raw material alcohol reflux of 40-60vol%, obtain extracting solution and
First dregs of a decoction；First dregs of a decoction are added water to cook again, filtrate and second dregs of a decoction are obtained after filtering.
Fermentation includes：It is concentrated in vacuo after extracting solution and filtrate are mixed, obtains the clear cream that relative density is 1.05-1.1；
Lactic acid bacteria is added in clear cream, is subsequently placed under the conditions of temperature is 25-30 DEG C and ferments, then sterilization treatment, obtain the first fermentation liquid.
Second dregs of a decoction are placed under the conditions of temperature is 30-32 DEG C and are fermented, decoction is added water and filters, obtain the second fermentation medicine
Liquid.
The fermentation liquid of mixing first and the second fermentation liquid.
The Chinese medicine pedicure prescription agent and preparation method thereof of the treatment ringworm of the foot of the embodiment of the present invention, tinea pedis, foot odour, itch has
Beneficial effect is：Preparation method can fully extract the active ingredient in medicinal raw material, to reduce the input of raw material；And
The prescription agent prepared by the preparation method can promote absorption of the human body to medicine, and then can improve effect and the healing for the treatment of
Rate etc..
Embodiment
, below will be in the embodiment of the present invention to make the purpose, technical scheme and advantage of the embodiment of the present invention clearer
Technical solution be clearly and completely described.The person that is not specified actual conditions in embodiment, builds according to normal condition or manufacturer
The condition of view carries out.Reagents or instruments used without specified manufacturer, is the conventional production that can be obtained by commercially available purchase
Product.
The treatment ringworm of the foot to the embodiment of the present invention, tinea pedis, foot odour, the Chinese medicine pedicure prescription agent of itch and its preparation side below
Method is specifically described.
The treatment ringworm of the foot of the present invention, tinea pedis, foot odour, the medicinal raw material of Chinese medicine pedicure prescription agent of itch include：5-10 weights
Measure the kuh-seng of part, the Asian puccoon of 5-10 parts by weight, the folium artemisiae argyi of 2-10 parts by weight, the Chinese prickly ash of 5-8 parts by weight, 5-10 parts by weight it is big
Huang, the fruit of summer cypress of 8-10 parts by weight, the Cortex Phellodendri of 15-20 parts by weight, the Golden Larch Bark of 1-5 parts by weight, 1-5 parts by weight the achene of Siberian cocklebur,
The peppermint of 1-5 parts by weight.
Preferably, above-mentioned medicinal raw material includes the kuh-seng of 8 parts by weight, the Asian puccoon of 8 parts by weight, the folium artemisiae argyi of 5 parts by weight, 6
The Chinese prickly ash of parts by weight, the rheum officinale of 6 parts by weight, the fruit of summer cypress of 9 parts by weight, the Cortex Phellodendri of 16 parts by weight, the Golden Larch Bark of 3 parts by weight, 3 weights
Measure the achene of Siberian cocklebur, the peppermint of 3 parts by weight of part.
Kuh-seng, Asian puccoon, folium artemisiae argyi, the fruit of summer cypress, Cortex Phellodendri, have the effects such as treatment eczema, wet sore, pruitus；Chinese prickly ash, can
For damp-clearing pain-relieving；Rheum officinale, can be used in hemostasis, antibacterial etc.；The achene of Siberian cocklebur, being capable of damp-clearing pain-relieving；Golden Larch Bark, has antibiotic and sterilizing
Deng effect；Peppermint, can relieve pain, the symptom such as itch.
The prescription agent prepared by above-mentioned medicinal raw material, is used in the ringworm of the foot, tinea pedis, foot odour, the sufferer of itch, Neng Gouming
The scratchiness of aobvious alleviation sufferer, avoids the foot ulceration of sufferer, and can also use the prescription even if the foot ulceration of sufferer
Agent, additionally it is possible to rapidly kill the various fungies of sufferer foot, accelerate sufferer foot and get well the speed of state.
The treatment ringworm of the foot, tinea pedis, foot odour, itch Chinese medicine pedicure prescription agent preparation method include prepare medicinal raw material,
Prepare extract and fermentation.
In detail, after preparing raw material according to the parts by weight of above-mentioned medicinal raw material, by the powder 40- of medicinal raw material
The alcohol reflux extraction of 60vol%, obtains extracting solution and first dregs of a decoction；First dregs of a decoction are added water to cook again, are filtered after filtering
Liquid and second dregs of a decoction.
The particle diameter of above-mentioned medicinal raw material powder can be 300-500 mesh, and can be each medicinal powder directly bought
Stock up according to required parts by weight；It can also be after being stocked up with the medicinal powder not being milled according to required parts by weight, return
Milling processing is carried out before stream extraction.
The weight ratio of above-mentioned medicinal raw material and 40-60vol% ethanol is 1:5-10, the temperature of refluxing extraction can be 30-
50 DEG C, the time of extraction can be 2-3h.According to the method described above carry out refluxing extraction can improve in medicinal raw material it is effective into
The it is proposed amount divided.
The time that first dregs of a decoction add water to cook can be 1-3h, and can also further be surpassed while decocting
Sonication, supersonic frequency can be 20-30KHz.The water added in first dregs of a decoction can be 3-5 times of the first dregs of a decoction weight.
Foregoing fermentation includes：It is concentrated in vacuo after extracting solution and filtrate are mixed, it is 1.05- to obtain relative density
The clear cream of 1.1 (35 DEG C), adds lactic acid bacteria in clear cream, is subsequently placed under the conditions of temperature is 25-30 DEG C and ferments, then the place that sterilizes
Reason, obtains the first fermentation liquid；Second dregs of a decoction are placed under the conditions of temperature is 30-32 DEG C and are fermented, decoction is added water and filters, obtain
To the second fermentation liquid；The fermentation liquid of mixing first and the second fermentation liquid.
It should be noted that above-mentioned vacuum drying can be -0.01MPa~-0.02MPa, temperature 40- in vacuum pressure
Carried out under the conditions of 50 DEG C；Above-mentioned sterilizing can with Technology of Ultra-high Pressure Sterilization of the prior art, cold sterilization, pasteurization,
Ultrahigh-temperature instant sterilization or microwave disinfection etc..
Further, the concentration of lactic acid bacteria can be 1 × 10 in above-mentioned clear cream4-105CFU/g.Lactic acid is added in clear cream
Bacterium is fermented, and can improve the ability that obtained prescription agent is absorbed by the body, and then improve the effect for the treatment of.Above-mentioned clear cream hair
The time of ferment can be 24-48h.It should be noted that the lactic acid bacteria of addition can be according to microorganism with commercially available lactic acid bacteria
Lactic acid bacteria after common various prior arts activation or it is autonomous after purification, active lactic acid bacteria.
The fermentation time of second dregs of a decoction can be 36-72h, and second dregs of a decoction are fermented a period of time at a higher temperature
Afterwards, decocting again further can extract the active ingredient in medicinal material, you can further to improve obtained medicine
The drug effect of prescription, improves therapeutic effect.When second dregs of a decoction after fermentation decoct, the water of addition is the 1-2 of the second dregs of a decoction weight
Times, the time of decoction can be 30-60min.
First fermentation liquid and second fermentation liquid mixing after, the liquid of mixing can be further made pulvis,
Granule, aqua or paste, such as：Pulvis is made in admixing medical solutions spray drying；Paste is made in admixing medical solutions concentration；Directly
Aqua is made in admixing medical solutions；Admixing medical solutions concentration postcooling is granulated granule etc. is made.
It should be noted that each parts by weight of above-mentioned medicinal raw material are identical, such as：Each parts by weight for 1kg,
1g etc..
With reference to embodiments to the treatment ringworm of the foot, tinea pedis, foot odour, the Chinese medicine pedicure prescription agent of itch and its system of the present invention
Preparation Method is described in further detail.
Embodiment 1
Prepare medicinal raw material, including：The kuh-seng of 5 parts by weight, the Asian puccoon of 10 parts by weight, the folium artemisiae argyi of 2 parts by weight, 5 parts by weight
Chinese prickly ash, the rheum officinale of 10 parts by weight, the fruit of summer cypress of 10 parts by weight, the Cortex Phellodendri of 15 parts by weight, the Golden Larch Bark of 5 parts by weight, 1 parts by weight
The achene of Siberian cocklebur, the peppermint of 5 parts by weight.
The powder of medicinal raw material is subjected to reflux extraction with the ethanol of 40vol%；Wherein, the weight of medicinal raw material and ethanol
Than for 1:5, the temperature of refluxing extraction is 30 DEG C, time 3h；Extracting solution and first dregs of a decoction are obtained after refluxing extraction.
First dregs of a decoction are added water to cook into 1h (100 DEG C), filtrate and second dregs of a decoction are obtained after filtering；Added in first dregs of a decoction
Water is 3 times of the first dregs of a decoction weight.
It is -0.01MPa that obtained extracting solution and filtrate are placed in vacuum pressure, and temperature is concentrated in vacuo under the conditions of being 40 DEG C,
The clear cream that relative density is 1.05 (35 DEG C) is obtained, lactic acid bacteria is added in obtained clear cream, is placed under the conditions of 25 DEG C, is fermented
24h, then microwave disinfection, obtain the first fermentation liquid；The concentration of lactic acid bacteria is 1 × 10 wherein in clear cream4CFU/g.By the second medicine
Slag is placed under the conditions of temperature is 30 DEG C the 36h that ferments, then adds the water of 1 times of amount of the second dregs of a decoction weight, decocts 30min, filtering, obtains
Second fermentation liquid.
After first fermentation liquid and the second fermentation liquid are mixed, pulvis is made in spray drying, you can the ringworm of the foot that obtains medical treatment,
The Chinese medicine pedicure prescription agent of tinea pedis, foot odour, itch.
Embodiment 2
Prepare medicinal raw material, including：The kuh-seng of 10 parts by weight, the Asian puccoon of 5 parts by weight, the folium artemisiae argyi of 10 parts by weight, 8 parts by weight
Chinese prickly ash, the rheum officinale of 5 parts by weight, the fruit of summer cypress of 8 parts by weight, the Cortex Phellodendris of 20 parts by weight, the Golden Larch Bark of 1 parts by weight, 5 parts by weight
The achene of Siberian cocklebur, the peppermint of 1 parts by weight.
The powder of medicinal raw material is subjected to reflux extraction with the ethanol of 60vol%；Wherein, the weight of medicinal raw material and ethanol
Than for 1:10, the temperature of refluxing extraction is 50 DEG C, time 2h；Extracting solution and first dregs of a decoction are obtained after refluxing extraction.
First dregs of a decoction are added water to cook into 3h (98 DEG C), filtrate and second dregs of a decoction are obtained after filtering；Added in first dregs of a decoction
Water is 5 times of the first dregs of a decoction weight.
It is -0.02MPa that obtained extracting solution and filtrate are placed in vacuum pressure, and temperature is concentrated in vacuo under the conditions of being 50 DEG C,
The clear cream that relative density is 1.1 (35 DEG C) is obtained, lactic acid bacteria is added in obtained clear cream, is placed under the conditions of 30 DEG C, is fermented
48h, then microwave disinfection, obtain the first fermentation liquid；The concentration of lactic acid bacteria is 1 × 10 wherein in clear cream5CFU/g.By the second medicine
Slag is placed under the conditions of temperature is 32 DEG C the 72h that ferments, then adds the water of 2 times of amounts of the second dregs of a decoction weight, decocts 60min, filtering, obtains
Second fermentation liquid.
After first fermentation liquid and the second fermentation liquid are mixed, paste is made in concentration, you can the ringworm of the foot that obtains medical treatment, foot
The Chinese medicine pedicure prescription agent of gas, foot odour, itch.
Embodiment 3
Prepare medicinal raw material, including：The kuh-seng of 8 parts by weight, the Asian puccoon of 8 parts by weight, the folium artemisiae argyi of 5 parts by weight, 6 parts by weight
Chinese prickly ash, the rheum officinale of 6 parts by weight, the fruit of summer cypress of 9 parts by weight, the Cortex Phellodendri of 16 parts by weight, the Golden Larch Bark of 3 parts by weight, 3 parts by weight it is grey
The peppermint of the ears or side handles of a utensil, 3 parts by weight.
The powder (300 mesh) of medicinal raw material is subjected to reflux extraction with the ethanol of 50vol%；Wherein, medicinal raw material and second
The weight ratio of alcohol is 1:7, the temperature of refluxing extraction is 40 DEG C, time 2.5h；Extracting solution and the first medicine are obtained after refluxing extraction
Slag.
First dregs of a decoction are added water to cook into 2h (99 DEG C), filtrate and second dregs of a decoction are obtained after filtering；Added in first dregs of a decoction
Water is 4 times of the first dregs of a decoction weight.
It is -0.01MPa that obtained extracting solution and filtrate are placed in vacuum pressure, and temperature is concentrated in vacuo under the conditions of being 45 DEG C,
The clear cream that relative density is 1.06 (35 DEG C) is obtained, lactic acid bacteria is added in obtained clear cream, is placed under the conditions of 27 DEG C, is fermented
36h, then microwave disinfection, obtain the first fermentation liquid；The concentration of lactic acid bacteria is 8 × 10 wherein in clear cream4CFU/g.By the second medicine
Slag is placed under the conditions of temperature is 31 DEG C the 50h that ferments, then adds the water of 1.5 times of amounts of the second dregs of a decoction weight, decocts 40min, filtering, obtains
To the second fermentation liquid.
After first fermentation liquid and the second fermentation liquid are mixed, aqua is made, you can the ringworm of the foot that obtains medical treatment, tinea pedis, foot
Smelly, itch Chinese medicine pedicure prescription agent.
Embodiment 4
Prepare medicinal raw material, including：The kuh-seng of 7 parts by weight, the Asian puccoon of 7 parts by weight, the folium artemisiae argyi of 5 parts by weight, 6 parts by weight
Chinese prickly ash, the rheum officinale of 7 parts by weight, the fruit of summer cypress of 9 parts by weight, the Cortex Phellodendri of 17 parts by weight, the Golden Larch Bark of 2 parts by weight, 4 parts by weight it is grey
The peppermint of the ears or side handles of a utensil, 2 parts by weight.
The powder (500 mesh) of medicinal raw material is subjected to reflux extraction with the ethanol of 45vol%；Wherein, medicinal raw material and second
The weight ratio of alcohol is 1:6, the temperature of refluxing extraction is 45 DEG C, time 2h；Extracting solution and first dregs of a decoction are obtained after refluxing extraction.
First dregs of a decoction are added water to cook into 2.5h (95 DEG C), filtrate and second dregs of a decoction are obtained after filtering；Added in first dregs of a decoction
Water be 3.5 times of the first dregs of a decoction weight, be ultrasonically treated while decocting, supersonic frequency 20KHz.
It is -0.015MPa that obtained extracting solution and filtrate are placed in vacuum pressure, and temperature is concentrated in vacuo under the conditions of being 45 DEG C,
The clear cream that relative density is 1.1 (35 DEG C) is obtained, lactic acid bacteria is added in obtained clear cream, is placed under the conditions of 28 DEG C, is fermented
30h, then microwave disinfection, obtain the first fermentation liquid；The concentration of lactic acid bacteria is 5 × 10 wherein in clear cream4CFU/g.By the second medicine
Slag is placed under the conditions of temperature is 30 DEG C the 60h that ferments, then adds the water of 1.2 times of amounts of the second dregs of a decoction weight, decocts 35min, filtering, obtains
To the second fermentation liquid.
After first fermentation liquid and the second fermentation liquid are mixed, granule is made in concentration, cooling granulation, you can is controlled
Treat the Chinese medicine pedicure prescription agent of the ringworm of the foot, tinea pedis, foot odour, itch.
Embodiment 5
Prepare medicinal raw material, including：The kuh-seng of 9 parts by weight, the Asian puccoon of 6 parts by weight, the folium artemisiae argyi of 8 parts by weight, 7 parts by weight
Chinese prickly ash, the rheum officinale of 6 parts by weight, the fruit of summer cypress of 8.5 parts by weight, the Cortex Phellodendri of 19 parts by weight, the Golden Larch Bark of 4 parts by weight, 2 parts by weight
The achene of Siberian cocklebur, the peppermint of 1 parts by weight.
The powder (400 mesh) of medicinal raw material is subjected to reflux extraction with the ethanol of 55vol%；Wherein, medicinal raw material and second
The weight ratio of alcohol is 1:7, the temperature of refluxing extraction is 42 DEG C, time 2.5h；Extracting solution and the first medicine are obtained after refluxing extraction
Slag.
First dregs of a decoction are added water to cook into 1.5h (97 DEG C), filtrate and second dregs of a decoction are obtained after filtering；Added in first dregs of a decoction
Water be 4.5 times of the first dregs of a decoction weight, be ultrasonically treated while decocting, supersonic frequency 30KHz.
It is -0.02MPa that obtained extracting solution and filtrate are placed in vacuum pressure, and temperature is concentrated in vacuo under the conditions of being 48 DEG C,
The clear cream that relative density is 1.05 (35 DEG C) is obtained, lactic acid bacteria is added in obtained clear cream, is placed under the conditions of 27 DEG C, is fermented
40h, then microwave disinfection, obtain the first fermentation liquid；The concentration of lactic acid bacteria is 7 × 10 wherein in clear cream4CFU/g.By the second medicine
Slag is placed under the conditions of temperature is 31 DEG C the 55h that ferments, then adds the water of 1.6 times of amounts of the second dregs of a decoction weight, decocts 48min, filtering, obtains
To the second fermentation liquid.
After first fermentation liquid and the second fermentation liquid are mixed, granule is made in concentration, cooling granulation, you can is controlled
Treat the Chinese medicine pedicure prescription agent of the ringworm of the foot, tinea pedis, foot odour, itch.
Embodiment 6
Prepare medicinal raw material, including：The kuh-seng of 9 parts by weight, the Asian puccoon of 6 parts by weight, the folium artemisiae argyi of 9 parts by weight, 7 parts by weight
Chinese prickly ash, the rheum officinale of 8 parts by weight, the fruit of summer cypress of 9 parts by weight, the Cortex Phellodendri of 19 parts by weight, the Golden Larch Bark of 4 parts by weight, 2 parts by weight it is grey
The peppermint of the ears or side handles of a utensil, 1 parts by weight.
The powder of medicinal raw material is subjected to reflux extraction with the ethanol of 57vol%；Wherein, the weight of medicinal raw material and ethanol
Than for 1:9, the temperature of refluxing extraction is 36 DEG C, time 2h；Extracting solution and first dregs of a decoction are obtained after refluxing extraction.
First dregs of a decoction are added water to cook into 1.8h (95 DEG C), filtrate and second dregs of a decoction are obtained after filtering；Added in first dregs of a decoction
Water be 4.2 times of the first dregs of a decoction weight, be ultrasonically treated while decocting, supersonic frequency 25KHz.
It is -0.01MPa that obtained extracting solution and filtrate are placed in vacuum pressure, and temperature is concentrated in vacuo under the conditions of being 45 DEG C,
The clear cream that relative density is 1.05 (35 DEG C) is obtained, lactic acid bacteria is added in obtained clear cream, is placed under the conditions of 26 DEG C, is fermented
42h, then microwave disinfection, obtain the first fermentation liquid；The concentration of lactic acid bacteria is 3 × 10 wherein in clear cream4CFU/g.By the second medicine
Slag is placed under the conditions of temperature is 32 DEG C the 42h that ferments, then adds the water of 1.8 times of amounts of the second dregs of a decoction weight, decocts 55min, filtering, obtains
To the second fermentation liquid.
After first fermentation liquid and the second fermentation liquid are mixed, granule is made in concentration, cooling granulation, you can is controlled
Treat the Chinese medicine pedicure prescription agent of the ringworm of the foot, tinea pedis, foot odour, itch.
Comparative example 1
The preparation method of comparative example 1 difference similar with the preparation method of embodiment 3 is, only medication in comparative example 1
Material raw material carries out reflux extraction, does not carry out the process after reflux extraction, and be prepared into pulvis, medicine with the extracting solution of reflux extraction
Weight, species and condition of reflux extraction of material raw material etc. refer to embodiment 3.
Comparative example 2
The preparation method and embodiment 3 of comparative example 2 are similar, and difference is, does not add in the medicinal raw material in comparative example 2
Add Golden Larch Bark, remaining method and step is with reference to embodiment 3.
Comparative example 3
The preparation method and embodiment 3 of comparative example 3 are similar, and difference is, does not add in the medicinal raw material in comparative example 3
Add the achene of Siberian cocklebur, remaining method and step is with reference to embodiment 3.
Comparative example 4
The preparation method and embodiment 3 of comparative example 4 are similar, and difference is, does not add in the medicinal raw material in comparative example 4
Add peppermint, remaining method and step is with reference to embodiment 3.
Comparative example 5
The preparation method and embodiment 3 of comparative example 5 are similar, and difference is, does not add in the medicinal raw material in comparative example 5
Add Golden Larch Bark, the achene of Siberian cocklebur and peppermint, remaining method and step reference
Embodiment 3.
Comparative example 6
The preparation method and embodiment 3 of comparative example 6 are similar, and difference is, does not add in the medicinal raw material in comparative example 6
Add Golden Larch Bark and peppermint, remaining method and step is with reference to embodiment 3.
Comparative example 7
The preparation method and embodiment 3 of comparative example 7 are similar, and difference is, does not add in the medicinal raw material in comparative example 7
Add Golden Larch Bark and the achene of Siberian cocklebur, remaining method and step is with reference to embodiment 3.
Obtained prescription agent in embodiment 1-6 and comparative example 1-7 is used for experimental investigation, chooses age bracket at 30-35 Sui
130, the 40-45 Sui female patient 130 of female patient of male patient 130 and 30-35 Sui of male patient 130,40-45 Sui
Example, and the course of disease is 50-60d, performance symptom is that can substantially see the ringworm of the foot, foot itch；13 test groups are randomly assigned again, often
Group 30-35 Sui male patient 10,40-45 Sui male patient 10,30-35 Sui female patient 10,40-45 Sui female patient
10.
It you can well imagine the prescription agent for embodiment 1-6 and comparative example 1-7 per component, every group of every night is with the prescriptions of 30g each groups
1L bubble foot 30min are added in agent, and 7d is as a treatment course, after a course for the treatment of, investigates whether the corresponding illness of each respondent has
Alleviated, criterion is as follows：
Recovery from illness：The ringworm of the foot substantially disappears, without pruritis；It is effective：Ringworm of the foot partial disappearance, pruritis weaken；It is invalid：Foot
Tinea does not substantially disappear, foot itch, even produces and festers phenomenon etc..It the results are shown in Table 1.
The effect of 1 each group prescription agent of table be'ss to respondent result (number)
According to the comparing result of comparative example 1 and embodiment 1-6, the extracting solution that is carried out in preparation method of the invention and
The fermentation of filtrate and the fermentation of the dregs of a decoction etc., can provide out drug effect higher, the prescription agent for promoting sufferer to absorb for oneself, and then can carry
The cure rate of high sufferer, improves giving full play to for medicinal raw material drug effect.
According to the comparing result of comparative example 2-7 and embodiment 1-6, the formula in preparation method of the invention can have
The symptoms such as effect ground treatment tinea pedis, itch, after adding Golden Larch Bark, the achene of Siberian cocklebur and peppermint in being particularly formulated, can significantly play
And improve the therapeutic effect of prescription agent tinea pedis.
In conclusion the Chinese medicine pedicure prescription agent of the treatment ringworm of the foot of the embodiment of the present invention, tinea pedis, foot odour, itch and its system
The beneficial effect of Preparation Method is：Preparation method can fully extract the active ingredient in medicinal raw material, to reduce former material
The input of material；And the prescription agent prepared by the preparation method can promote absorption of the human body to medicine, and then treatment can be improved
Effect and cure rate etc..
Embodiments described above is part of the embodiment of the present invention, instead of all the embodiments.The reality of the present invention
The detailed description for applying example is not intended to limit the scope of claimed invention, but is merely representative of the selected implementation of the present invention
Example.Based on the embodiments of the present invention, those of ordinary skill in the art are obtained without creative efforts
Every other embodiment, belongs to the scope of protection of the invention.
Claims (10)
1. a kind of Chinese medicine pedicure prescription agent for treating the ringworm of the foot, tinea pedis, foot odour, itch, it is characterised in that its medicinal raw material includes：
The kuh-seng of 5-10 parts by weight, the Asian puccoon of 5-10 parts by weight, the folium artemisiae argyi of 2-10 parts by weight, the Chinese prickly ash of 5-8 parts by weight, 5-10 parts by weight
Rheum officinale, the fruit of summer cypress of 8-10 parts by weight, the Cortex Phellodendri of 15-20 parts by weight, the Golden Larch Bark of 1-5 parts by weight, the Siberian cocklebur of 1-5 parts by weight
Son, the peppermint of 1-5 parts by weight.
2. the Chinese medicine pedicure prescription agent of the treatment ringworm of the foot, tinea pedis, foot odour, itch according to claim 1, it is characterised in that
The medicinal raw material includes：The kuh-seng of 8 parts by weight, the Asian puccoon of 8 parts by weight, the folium artemisiae argyi of 5 parts by weight, 6 weight
The Chinese prickly ash of part, the rheum officinale of 6 parts by weight, the fruit of summer cypress of 9 parts by weight, the Cortex Phellodendri of 16 parts by weight, 3 parts by weight
The Golden Larch Bark, the achene of Siberian cocklebur, the peppermint of 3 parts by weight of 3 parts by weight.
3. it is a kind of treat the ringworm of the foot, tinea pedis, foot odour, itch Chinese medicine pedicure prescription agent preparation method, it is characterised in that including standard
Standby medicinal raw material, prepare extract and fermentation, wherein,
The medicinal raw material includes：The kuh-seng of 5-10 parts by weight, the Asian puccoon of 5-10 parts by weight, the folium artemisiae argyi of 2-10 parts by weight, 5-8 weights
Measure the Chinese prickly ash of part, the rheum officinale of 5-10 parts by weight, the fruit of summer cypress of 8-10 parts by weight, the Cortex Phellodendris of 15-20 parts by weight, 1-5 parts by weight
Golden Larch Bark, the achene of Siberian cocklebur of 1-5 parts by weight, the peppermint of 1-5 parts by weight；
The extract for preparing includes extracting the powder of the medicinal raw material alcohol reflux of 40-60vol%, is extracted
Liquid and first dregs of a decoction；First dregs of a decoction are added water to cook again, filtrate and second dregs of a decoction are obtained after filtering；
The fermentation includes：It is concentrated in vacuo after the extracting solution and the filtrate are mixed, it is 1.05-1.1 to obtain relative density
Clear cream；Lactic acid bacteria is added in the clear cream, is subsequently placed under the conditions of temperature is 25-30 DEG C and ferments, then sterilization treatment, obtain
First fermentation liquid；Second dregs of a decoction are placed under the conditions of temperature is 30-32 DEG C and are fermented, decoction is added water and filters, obtain
Second fermentation liquid；Mix the first fermentation liquid and the second fermentation liquid.
4. the preparation method of the Chinese medicine pedicure prescription agent of the treatment ringworm of the foot according to claim 3, tinea pedis, foot odour, itch, its
It is characterized in that, the weight ratio of the medicinal raw material and the ethanol of the 40-60vol% is 1:5-10.
5. the preparation method of the Chinese medicine pedicure prescription agent of the treatment ringworm of the foot according to claim 3, tinea pedis, foot odour, itch, its
It is characterized in that, the temperature of the refluxing extraction is 30-50 DEG C, time 2-3h.
6. the preparation method of the Chinese medicine pedicure prescription agent of the treatment ringworm of the foot according to claim 3, tinea pedis, foot odour, itch, its
It is characterized in that, the concentration of the lactic acid bacteria in the clear cream is 1 × 104-105CFU/g。
7. the preparation method of the Chinese medicine pedicure prescription agent of the treatment ringworm of the foot according to claim 3, tinea pedis, foot odour, itch, its
It is characterized in that, the fermentation time of the clear cream is 24-48h.
8. the preparation method of the Chinese medicine pedicure prescription agent of the treatment ringworm of the foot according to claim 3, tinea pedis, foot odour, itch, its
It is characterized in that, the time of second dregs of a decoction fermentation is 36-72h.
9. the preparation method of the Chinese medicine pedicure prescription agent of the treatment ringworm of the foot according to claim 3, tinea pedis, foot odour, itch, its
It is characterized in that, the time that first dregs of a decoction add water to cook is 1-3h.
10. the preparation method of the Chinese medicine pedicure prescription agent of the treatment ringworm of the foot according to claim 3, tinea pedis, foot odour, itch,
It is characterized in that, pulvis, granule, aqua or cream is made after the described first fermentation liquid and the second fermentation liquid are mixed
Agent.
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