CN107050298A - A kind of Chinese medicine paste formulation and preparation method for treating burn and scald skin damaged - Google Patents
A kind of Chinese medicine paste formulation and preparation method for treating burn and scald skin damaged Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/02—Algae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/30—Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/739—Sanguisorba (burnet)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
Abstract
The invention discloses a kind of Chinese medicine paste formulation and preparation method for treating burn and scald skin damaged, including Chinese medicine paste formulation, Chinese medicinal ointment preparation method, traditional Chinese powder medicine preparation method, Traditional Chinese medicine tincture preparation preparation method, characterized in that, the active ingredient and its mass fraction of the Chinese medicine paste formulation of the treatment burn and scald skin damaged are：8 parts of rheum officinale, 8 parts of the coptis, 5 parts of giant knotweed, 5 parts of golden cypress, 8 parts of garden burnet, 6 parts of the bletilla striata, 9 parts of honeysuckle, 7 parts of Crinis Carbonisatus, 10 parts of Asian puccoon, 7 parts of the root of Dahurain angelica, 10 parts of elm bark, 8 parts of borneol, 5 parts of peppermint, 5 parts of rde bean, 5 parts of kelp.The invention also discloses a kind of preparation method of three kinds of Chinese medicine preparations of the Chinese medicine paste formulation for treating burn and scald skin damaged：Chinese medicinal ointment preparation method, traditional Chinese powder medicine preparation method, Traditional Chinese medicine tincture preparation preparation method.
Description
Technical field
The present invention relates to a kind of technical field of traditional Chinese medicines, more particularly to a kind of treat in burn and scald skin damaged
Medical ointment prescription and preparation method.
Background technology
The Chinese and Western medicine of the treatment burn and scald of prior art and the formula of Chinese materia medica preparation for treating burn and scald skin damaged
It is innumerable, have the following disadvantages mostly：Analgesic effect is poor, and patient suffering is larger during dressing, medicine
Thing antibacterial ability is poor, and wound healing is slow, and the course of disease is longer, typically all needs to coordinate skin grafting and amputation
Can be only achieved patient's majority after healing, healing turns into disabled person and influences quality of life later, so that
Aggravate the burden of country, family and sufferer.
Chinese medicine paste formulation of the present invention uses rheum officinale, the coptis, giant knotweed, golden cypress, garden burnet, the bletilla striata, gold
Honeysuckle flower, Crinis Carbonisatus etc. are constituted, and all medicines gather dispel rotten apocenosis, the anti-inflammatory of nourshing blood and promoting blood circulation, promoting granulation and relieving pain and resisted altogether
Bacterium promotes the function of skin and regeneration, and composition internal cause contains polysaccharide, Anthraquinones, tannin class and work
The compositions such as blood stagnation resolvation, energy putrefaction-removing granulation-promoting, anti-inflammation, analgesic hemostatic, improvement surface of a wound blood circulation,
Promote the skin and tissue cell proliferation of the surface of a wound, division, regeneration.Make wound tissue in-situ immobilization,
So as to accelerating wound healing, reduce scar tissue and formed.Overcome the deficiencies in the prior art.
The content of the invention
1st, it is an object of the invention to provide a kind of Chinese medicine paste formulation for treating burn and scald skin damaged, rationally
The Chinese medicine paste formulation analgesic effect that ground solves the treatment burn and scald skin damaged of prior art is poor, during dressing
The problems such as patient suffering is big.
The present invention is adopted the following technical scheme that：
A kind of Chinese medicine paste formulation and preparation method for treating burn and scald skin damaged, including Chinese medicine paste formulation,
Chinese medicinal ointment preparation method, traditional Chinese powder medicine preparation method, Traditional Chinese medicine tincture preparation preparation method, its feature exists
In the active ingredient and its mass fraction of the Chinese medicine paste formulation of the treatment burn and scald skin damaged are：Greatly
6-12 parts of yellow (RADIX ET RHIZOMA RHEI), the coptis (COPTIS CHINENSIS FRANCH.)
6-12 parts, giant knotweed (RHIZOMA POLYGONI CUSPIDATI) 3-7 parts, golden cypress (CORTEX
PHELLODENDRI) 3-9 parts, 5-12 parts of garden burnet (RADIX SANGUISORBAE), the bletilla striata
3-9 parts of (BLETILLA STRIATA), 6-12 parts of honeysuckle (LONICERA JAPONICA),
5-12 parts of Crinis Carbonisatus (CRINIS CARBONISATUS), Asian puccoon (RADIX ARNEBIAE/RADIX
LITHOSPERMI) 6-15 parts, 5-12 parts of the root of Dahurain angelica (ANGELICA DAHURICA), elm bark
9-15 parts of (ULMUS PUMILA L.), 6-10 parts of borneol (BORNEOLUM SYNTHETICUM),
3-9 parts of peppermint (MENTHA HAPLOCALYX BRIQ.), rde bean (VIGNA UMBELLATA)
3-7 parts, 3-7 parts of kelp (ECKLONIA KUROME).
The most preferably active ingredient and its mass fraction of the Chinese medicine paste formulation of the treatment burn and scald skin damaged
For：8 parts of rheum officinale (RADIX ET RHIZOMA RHEI), the coptis (COPTIS CHINENSIS FRANCH.)
8 parts, 5 parts of giant knotweed (RHIZOMA POLYGONI CUSPIDATI), golden cypress (CORTEX
PHELLODENDRI) 5 parts, 8 parts of garden burnet (RADIX SANGUISORBAE), the bletilla striata (BLETILLA
STRIATA) 6 parts, 9 parts of honeysuckle (LONICERA JAPONICA), Crinis Carbonisatus (CRINIS
CARBONISATUS) 7 parts, Asian puccoon (RADIX ARNEBIAE/RADIX LITHOSPERMI) 10
Part, 7 parts of the root of Dahurain angelica (ANGELICA DAHURICA), elm bark (ULMUS PUMILA L.) 10
Part, 8 parts of borneol (BORNEOLUM SYNTHETICUM), peppermint (MENTHA HAPLOCALYX BRIQ.)
5 parts, 5 parts of rde bean (VIGNA UMBELLATA), 5 parts of kelp (ECKLONIA KUROME).
Further, the Chinese medicine paste formulation of the treatment burn and scald skin damaged is external application Chinese medicine paste formulation.
The pharmacological action of Chinese medicine material：
Borneol, Herba Menthae powder (MOSCHUS BEREZOVSKII FLEROV)：Borneol, Herba Menthae powder taste
It is pungent, it is warm-natured；The thoughts of returning home, liver, the spleen channel；It is fragrant it is strong alter scattered, can rise to drop, with inducing resuscitation of having one's ideas straightened out, living
Blood dissipating bind, alleviating pain and detumescence expedites the emergence of effect of lower tire, cures mainly pyreticosis coma, apoplexy coma due to blocking of the respiratory system, the obstruction of the circulation of vital energy
Faint cruelly, middle evil is gone into a coma, blood stasis, dysmenorrhoea, accumulation, trusted subordinate sudden and violent pain, arthralgia pain due to rheumatism, bruise
Damage, ulcer malignant sore, larynx numbness, aphtha.
Modern study shows：Immunologic function, borneol, Herba Menthae powder water-solubility protein to humoral immunity and
Cellular immunity has humidification.Germicidal efficacy is to borneol, Herba Menthae powder to intraperitoneal injection sheep red blood cell (SRBC)
Immune mouse produces antibody gavage M unrestraints effect.Seemingly there is humidification.Borneol, Herba Menthae powder without
Immune induction is acted on, but in the presence of antigen sheep red blood cell (SRBC), borneol, Herba Menthae powder can make experiment small
Mouse spleen is significantly increased.
Antitumor action, natural borneol, Herba Menthae powder or borneol, Herba Menthae powder ketone are to mouse Emhorn ascites
Cancer, S37 and S180 cellular respiration inhibiting rate, are above normal mouse inhibiting rate.The country is used
Different way of administration, and from different sensitive knurl strains, naturally with synthetic borneol, Herba Menthae powder ketone to W256
Ascites tumor, W256 solid tumors, the knurl such as S180 sarcomas and L615 mouse leukemias spectrum is without substantially
Inhibitory action, from the experimental results, borneol, Herba Menthae powder in vitro animal cancer cell have destruction make
With, there is obvious inhibiting effect to the cellular respiration of animal tumor tissue, and antitumor reality in animal body
Test not it is observed that curative effect.
Other effects, 2% borneol, 1: 400 dilution of Herba Menthae powder tincture, can suppress pig suddenly in vitro
The growth of random vibrios, Escherichia coli and S. aureus L-forms.Borneol, Herba Menthae powder water extract can significantly improve kidney
Cortisone, cAMP, PGE, PGF2a content in upper gland vitamin C and blood, and have suppression blood small
Plate aggtegation.In addition, also anti-snake venom and antihistamine etc. are acted on.
Elm bark (ULMUS PUMILA L.)：It is sweet, flat.It is nontoxic.Li Shui, treating stranguria, detumescence.
The coptis (COPTIS CHINENSIS FRANCH.)：Bitter, it is cold in nature.The thoughts of returning home, spleen, stomach,
Liver, courage, large intestine channel.Heat-clearing and damp-drying drug, purging intense heat and detonicating.Dysphoria and insomnia is cured mainly, palpitation and uneasiness disappears
Yearningly, carbuncle swells treat sore；Control eczema, wet sore outside.
Rheum officinale has very strong anti-infective, hemostasis, analgesic effect, to a variety of Gram-positives and the moon
Property bacterium have inhibitory action, it is especially sensitive to staphylococcus and streptococcus.The coptis：Hardship cold in nature.Tool
Purging intense heat, eliminating dampness, removing toxic substances, the function of desinsection, modern pharmacological research prove coptis tool broad spectrum antibacterial,
It is especially sensitive to staphylococcus aureus, hemolytic streptococcus.Giant knotweed：Mildly bitter flavor, it is mild-natured.Contain
The composition such as Anthraquinones rheum emodin and resveratrol.Tool protects vascular endothelial cell and prevents thrombosis,
Promote microcirculation.Golden cypress：Nature and flavor are destitute, hemostasis and pain-relieving, anti-infective.Garden burnet：Cooling blood and hemostasis,
It is clearing heat and detoxicating, cure mainly sore pain and swell and ache, scald.The bletilla striata：Bearberry Extract stops blooding, detumescence and promoting granulation,
The effect of soup fire burn, to golden yellow golden staphylococci, hay bacillus, Bacillus tuberculosis have suppression
Effect.Honeysuckle：Containing chlorogenic acid, inositol etc..With sterilization anti-microbial effect, to green pus bar
The various pathogens such as bacterium, hemolytic streptococcus, staphylococcus aureus have sterilization, bacteriostasis.
Crinis Carbonisatus：Have hemostasis, antibacterial, myogenic effect.Asian puccoon：Have swelling and pain relieving, putrefaction-removing granulation-promoting, receipts
The effect of holding back hemostasis！The root of Dahurain angelica：Detumescence and apocenosis, analgesic, suppress bacterium and fungi.Elm bark：It is main
Control detumescence, ulcer etc..Borneol：Promote Drug Percutaneous Absorption, have clearing away heat to and alleviating pain, erosion prevention and muscle growing,
Anti-inflammation, can increase granulation tissue structure and reepithelialization, repair skin accessory organ and
Tool promotes Wound Healing.Peppermint：Containing peppermint acid and menthones, anti-inflammatory analgetic, anti-itch detoxification
Effect.Rde bean：Solve sore, anti-inflammation detumescence.Kelp：Nature and flavor are salty-cold, diminishing inflammation and resolving masses, kill true
Bacterium.All medicines gather dispel rotten apocenosis, antiphlogistic antibacterial of nourshing blood and promoting blood circulation, promoting granulation and relieving pain and promote skin and tissue altogether
The function of regeneration.
2 the present invention also aims to provide the three of a kind of Chinese medicine paste formulation for treating burn and scald skin damaged
Plant the preparation method of Chinese medicine preparation, the preparation method of traditional Chinese medicinal ointment of (1) described treatment burn and scald skin damaged
Including adding vaseline prothetic group and following steps：
Step 1: getting the raw materials ready：Chinese medicine material is weighed by the Chinese medicine paste formulation of the treatment burn and scald skin damaged；
Step 2: standby prothetic group：By the Chinese medicine material of the Chinese medicine paste formulation of the treatment burn and scald skin damaged
Gross mass part 1: 19 weighs vaseline prothetic group；
Chinese medicine material powder is made Step 3: crushing：Chinese medicine material that step one is weighed altogether levigation into
Smalls is mixed evenly, and the independent levigation of borneol, peppermint is standby；
Step 4: once boiling：Chinese medicine material powder made from the step 3 is slowly added into heating
Vaseline in and be stirred continuously, make it uniform, just to see that oil smoke, to spend, 20-30 is boiled with slow fire again
Minute, residue is pulled out；
Step 5: secondary boil：Borneol, Herba Menthae powder are added, is stirred continuously and is allowed to dissolve, then endure
It is processed 4-5 minutes；
Step 6: being cooled to traditional Chinese medicinal ointment.
(2) the traditional Chinese powder medicine preparation method is to match somebody with somebody the traditional Chinese medicinal ointment by the treatment burn and scald skin damaged
The Chinese medicine material that side is weighed is ground into smalls jointly, crosses 120 mesh sieves and takes, and sterilization sealing is prepared
The traditional Chinese powder medicine of the external-used burn and scald treating skin damaged of the Chinese medicine paste formulation of the treatment burn and scald skin damaged.
(3) the Traditional Chinese medicine tincture preparation preparation method is to match somebody with somebody the traditional Chinese medicinal ointment by the treatment burn and scald skin damaged
The Chinese medicine material mixture that side is weighed is put into 75% alcohol and sealed, and immersion prepares described on the 20th
Treat the Traditional Chinese medicine tincture preparation of the external-used burn and scald treating skin damaged of the Chinese medicine paste formulation of burn and scald skin damaged.
Further, by the Chinese medicinal ointment preparation side of the Chinese medicine paste formulation for treating burn and scald skin damaged
The product that step 5 is made in method, the gauze disinfected or non-woven fabrics are impregnated with while hot can prepare burning and scald
Hinder the external application dressing of the surface of a wound.
The method have the benefit that：
(1) the invention discloses a kind of Chinese medicine paste formulation for treating burn and scald skin damaged, reasonably solve
The Chinese medicine paste formulation analgesic effect of the treatment burn and scald skin damaged of prior art is poor, and patient is bitterly during dressing
Bitter big the problem of.Chinese medicine paste formulation of the present invention using rheum officinale, the coptis, giant knotweed, golden cypress, garden burnet,
The bletilla striata, honeysuckle, Crinis Carbonisatus etc. are constituted, all medicines gather altogether nourshing blood and promoting blood circulation, promoting granulation and relieving pain dispel rotten apocenosis,
Antiphlogistic antibacterial promotes the function of skin and regeneration, and composition internal cause contains polysaccharide, Anthraquinones, tannin
Class and the composition such as promoting blood circulation and removing blood stasis, can putrefaction-removing granulation-promoting, anti-inflammation, analgesic hemostatic, improve surface of a wound blood
Liquid is circulated, and promotes the skin and tissue cell proliferation of the surface of a wound, division, regeneration.Make wound tissue former
Position is repaired, so that accelerating wound healing, reduces scar tissue and formed.Overcome prior art not
Foot.
(2) the invention also discloses a kind of three kinds of Chinese medicines of the Chinese medicine paste formulation for treating burn and scald skin damaged
The preparation method of preparation：It is prepared by Chinese medicinal ointment preparation method, traditional Chinese powder medicine preparation method, Traditional Chinese medicine tincture preparation
Method.
Embodiment
By the following description to embodiment, it will more contribute to the public understanding present invention, but can not
Specific embodiment given by applicant should not be also considered as to the limit to technical solution of the present invention
System, any definition to part or technical characteristic be changed and/or overall structure made form and
Immaterial conversion is regarded as the protection domain that technical scheme is limited.
Experimental example
1st, clinical data：80 burned patients of this group, wherein, man 48, female 32；
It is age 1-85 Sui, average 32.6 years old；Severe infections 49, high fever 6, anemia 13
Example, electrolyte imbalance 2.It is divided into three-level according to burn and scald diagnostic criteria：I degree is burnt：Injure
Epidermis shallow-layer, basalis is remained.Local skin is rubescent, swelling, pain, have burn feeling, it is anhydrous
Blister, fully recovers for 3~5 days.More scar is not stayed after, there can be temporary pigmentation.Shallow II degree burn：It is tired
And epidermis and papillary layer of corium, local red and swollen, sepage is more and forms differ in size blister, the surface of a wound
Moistening, wound bottom is scarlet, oedema, severe pain；If can be in recovery from illness, no scar shape in 2 weeks without infection etc.
Into can have temporary pigmentation.Deep ii degree burn：Involve reticular layer of corium, but still residual part
Divide corium and the appendages of skin.Local swelling, white or brown color, blister are smaller.It is insensitive,
Pi Wen is slightly lower, and pain is lighter.As insentience can in 3-4 weeks heal, scar is left more afterwards, but
Skin function is preserved substantially.Deep III burns：Involve skin holostrome even subcutaneous fat, muscle,
Internal organs.The surface of a wound is pale or sallow charing, and without pain, no blister, anesthesia, matter is tough seemingly
Leather.Granulation tissue face is left after eschar comes off after 3-4 weeks, scar, skin function funeral are left more afterwards
Lose, cause deformity.
By table of random number, observation group's (invention formulation group) and control group, each 40 are randomly divided into
Example.Two groups of patient ages, sex, burn and scalds are classified (object is I/II/III grades) and area
It is statistically analyzed, there was no significant difference, with comparativity.
2nd, treatment method：While systematic treating burn and scald protopathy and complication, active prevention
The malignant conditions such as infection, bleeding do not occur.As changed 2 medicines, cooperation relevant clinical initial stage daily
Section's expert consultation, handles related complication.Combination physical therapy is such as entered with excusing from death waveguide, red light irradiation.
Invention formulation group：I grades：Surface of a wound slough is removed in sterilization, and ointment is evenly coated in wound
And surrounding, gauze wrapping, same day dressing 2 times.II/III degree：Sterile surgical removes bubble and
Skin and tissue through gangrenous necrosis completely, then the surface of a wound apply ointment, gauze wrapping is changed daily
Medicine 2 times, 90 days observation curative effects.
Control group：I grades are used the normal saline flushing surface of a wound, 0.5% iodophor disinfection periwound skin, it
160,000 U gentamicin liquid are soaked with appropriately sized gauze layer 2-3 afterwards and spread on the surface of a wound, aseptic dressing
Wrapping, daily dressing 2 times.II/III grades：The surface of a wound is cleaned with 0.02% furacillin solution, it is other
Ibid, 90 days observation curative effects.
3rd, statistical result
After total course for the treatment of of 90 days terminates, two groups of therapeutic effects, which are relatively shown in Table 1. invention formulation groups, to be had
Efficiency 100%, cure rate 90%, better than control group 37.50%.
Table 1：Two groups of therapeutic effects compare
Two groups of cure time comparison sheets 2. show that the salve for treating burn and scald group course for the treatment of is significantly shorter than control group.Control
Do not find that Chinese medicine invention group has any adverse reaction during treatment.
Table 2：Two groups of cure times compare
Embodiment one
A kind of Chinese medicine paste formulation and preparation method for treating burn and scald skin damaged as described in experimental example, including
Chinese medicine paste formulation, Chinese medicinal ointment preparation method, traditional Chinese powder medicine preparation method, Traditional Chinese medicine tincture preparation preparation side
Method.
It is described treatment burn and scald skin damaged Chinese medicine paste formulation active ingredient and its mass fraction be：Greatly
6-12 parts of yellow (RADIX ET RHIZOMA RHEI), the coptis (COPTIS CHINENSIS FRANCH.)
6-12 parts, giant knotweed (RHIZOMA POLYGONI CUSPIDATI) 3-7 parts, golden cypress (CORTEX
PHELLODENDRI) 3-9 parts, 5-12 parts of garden burnet (RADIX SANGUISORBAE), the bletilla striata
3-9 parts of (BLETILLA STRIATA), 6-12 parts of honeysuckle (LONICERA JAPONICA),
5-12 parts of Crinis Carbonisatus (CRINIS CARBONISATUS), Asian puccoon (RADIX ARNEBIAE/RADIX
LITHOSPERMI) 6-15 parts, 5-12 parts of the root of Dahurain angelica (ANGELICA DAHURICA), elm bark
9-15 parts of (ULMUS PUMILA L.), 6-10 parts of borneol (BORNEOLUM SYNTHETICUM),
3-9 parts of peppermint (MENTHA HAPLOCALYX BRIQ.), rde bean (VIGNA UMBELLATA)
3-7 parts, 3-7 parts of kelp (ECKLONIA KUROME).
Embodiment two
The most preferably active ingredient and its mass fraction of the Chinese medicine paste formulation of the treatment burn and scald skin damaged
For：8 parts of rheum officinale (RADIX ET RHIZOMA RHEI), the coptis (COPTIS CHINENSIS FRANCH.)
8 parts, 5 parts of giant knotweed (RHIZOMA POLYGONI CUSPIDATI), golden cypress (CORTEX
PHELLODENDRI) 5 parts, 8 parts of garden burnet (RADIX SANGUISORBAE), the bletilla striata (BLETILLA
STRIATA) 6 parts, 9 parts of honeysuckle (LONICERA JAPONICA), Crinis Carbonisatus (CRINIS
CARBONISATUS) 7 parts, Asian puccoon (RADIX ARNEBIAE/RADIX LITHOSPERMI) 10
Part, 7 parts of the root of Dahurain angelica (ANGELICA DAHURICA), elm bark (ULMUS PUMILA L.) 10
Part, 8 parts of borneol (BORNEOLUM SYNTHETICUM), peppermint (MENTHA HAPLOCALYX BRIQ.)
5 parts, 5 parts of rde bean (VIGNA UMBELLATA), 5 parts of kelp (ECKLONIA KUROME).
Embodiment three
It is described treatment burn and scald skin damaged traditional Chinese medicinal ointment preparation method include add vaseline prothetic group and with
Lower step：
Step 1: getting the raw materials ready：Chinese medicine material is weighed by the Chinese medicine paste formulation of the treatment burn and scald skin damaged；
Step 2: standby prothetic group：By the Chinese medicine material of the Chinese medicine paste formulation of the treatment burn and scald skin damaged
Gross mass part 1: 19 weighs vaseline prothetic group；
Chinese medicine material powder is made Step 3: crushing：Chinese medicine material that step one is weighed altogether levigation into
Smalls is mixed evenly, and the independent levigation of borneol, peppermint is standby；
Step 4: once boiling：Chinese medicine material powder made from the step 3 is slowly added into heating
Vaseline in and be stirred continuously, make it uniform, just to see that oil smoke, to spend, 20-30 is boiled with slow fire again
Minute, residue is pulled out；
Step 5: secondary boil：Borneol, Herba Menthae powder are added, is stirred continuously and is allowed to dissolve, then endure
It is processed 4-5 minutes；
Step 6: being cooled to traditional Chinese medicinal ointment.
Example IV
The traditional Chinese powder medicine preparation method is to claim the Chinese medicine paste formulation by the treatment burn and scald skin damaged
The Chinese medicine material taken is ground into smalls jointly, crosses 120 mesh sieves and takes, and sterilization sealing is prepared described
Treat the traditional Chinese powder medicine of the external-used burn and scald treating skin damaged of the Chinese medicine paste formulation of burn and scald skin damaged.
Embodiment five
The Traditional Chinese medicine tincture preparation preparation method is to claim the Chinese medicine paste formulation by the treatment burn and scald skin damaged
The Chinese medicine material mixture taken is put into 75% alcohol and sealed, and immersion prepares the treatment on 20th
The Traditional Chinese medicine tincture preparation of the external-used burn and scald treating skin damaged of the Chinese medicine paste formulation of burn and scald skin damaged.
Certainly, the present invention can also have other various embodiments, without departing substantially from spirit of the invention and its
In the case of essence, those skilled in the art can make various corresponding according to the present invention
Change and deform, but these corresponding changes and deformation should all belong to appended claims of the invention
Protection domain.
Claims (6)
1. a kind of Chinese medicine paste formulation and preparation method for treating burn and scald skin damaged, including Chinese medicine paste formulation,
Chinese medicinal ointment preparation method, traditional Chinese powder medicine preparation method, Traditional Chinese medicine tincture preparation preparation method, its feature exists
In the active ingredient and its mass fraction of the Chinese medicine paste formulation of the treatment burn and scald skin damaged are：Greatly
6-12 parts of yellow (RADIX ET RHIZOMA RHEI), the coptis (COPTIS CHINENSIS FRANCH.)
6-12 parts, giant knotweed (RHIZOMA POLYGONI CUSPIDATI) 3-7 parts, golden cypress (CORTEX
PHELLODENDRI) 3-9 parts, 5-12 parts of garden burnet (RADIX SANGUISORBAE), the bletilla striata
3-9 parts of (BLETILLA STRIATA), 6-12 parts of honeysuckle (LONICERA JAPONICA),
5-12 parts of Crinis Carbonisatus (CRINIS CARBONISATUS), Asian puccoon (RADIX ARNEBIAE/RADIX
LITHOSPERMI) 6-15 parts, 5-12 parts of the root of Dahurain angelica (ANGELICA DAHURICA), elm bark
9-15 parts of (ULMUS PUMILA L.), 6-10 parts of borneol (BORNEOLUM SYNTHETICUM),
3-9 parts of peppermint (MENTHA HAPLOCALYX BRIQ.), rde bean (VIGNA UMBELLATA)
3-7 parts, 3-7 parts of kelp (ECKLONIA KUROME)；
It is described treatment burn and scald skin damaged traditional Chinese medicinal ointment preparation method include add vaseline prothetic group and with
Lower step：
Step 1: getting the raw materials ready：Chinese medicine material is weighed by the Chinese medicine paste formulation of the treatment burn and scald skin damaged；
Step 2: standby prothetic group：By the Chinese medicine material of the Chinese medicine paste formulation of the treatment burn and scald skin damaged
Gross mass part 1: 19 weighs vaseline prothetic group；
Chinese medicine material powder is made Step 3: crushing：Chinese medicine material that step one is weighed altogether levigation into
Smalls is mixed evenly, and the independent levigation of borneol, peppermint is standby；
Step 4: once boiling：Chinese medicine material powder made from the step 3 is slowly added into heating
Vaseline in and be stirred continuously, make it uniform, just to see that oil smoke, to spend, 20-30 is boiled with slow fire again
Minute, residue is pulled out；
Step 5: secondary boil：Borneol, Herba Menthae powder are added, is stirred continuously and is allowed to dissolve, then endure
It is processed 4-5 minutes；
Step 6: being cooled to traditional Chinese medicinal ointment.
2. a kind of Chinese medicine paste formulation for treating burn and scald skin damaged and preparation side according to claim 1
Method, it is characterised in that the most preferably active ingredient of the Chinese medicine paste formulation of the treatment burn and scald skin damaged
And its mass fraction is：8 parts of rheum officinale (RADIX ET RHIZOMA RHEI), the coptis (COPTIS
CHINENSIS FRANCH.) 8 parts, 5 parts of giant knotweed (RHIZOMA POLYGONI CUSPIDATI),
5 parts of golden cypress (CORTEX PHELLODENDRI), 8 parts of garden burnet (RADIX SANGUISORBAE),
6 parts of the bletilla striata (BLETILLA STRIATA), 9 parts of honeysuckle (LONICERA JAPONICA),
7 parts of Crinis Carbonisatus (CRINIS CARBONISATUS), Asian puccoon (RADIX ARNEBIAE/RADIX
LITHOSPERMI) 10 parts, 7 parts of the root of Dahurain angelica (ANGELICA DAHURICA), elm bark (ULMUS
PUMILA L.) 10 parts, 8 parts of borneol (BORNEOLUM SYNTHETICUM), peppermint (MENTHA
HAPLOCALYX BRIQ.) 5 parts, 5 parts of rde bean (VIGNA UMBELLATA), kelp (ECKLONIA
KUROME) 5 parts.
3. a kind of Chinese medicine paste formulation for treating burn and scald skin damaged and preparation side according to claim 1
Method, it is characterised in that the Chinese medicine paste formulation of the treatment burn and scald skin damaged is external application Chinese medicine paste formulation.
4. a kind of Chinese medicine paste formulation for treating burn and scald skin damaged and preparation side according to claim 1
Method, it is characterised in that prepared by the Chinese medicinal ointment of the Chinese medicine paste formulation of the treatment burn and scald skin damaged
The product that step 5 is made in method, the gauze disinfected or non-woven fabrics are impregnated with while hot can prepare burning
The external application dressing of scald wound.
5. a kind of Chinese medicine paste formulation for treating burn and scald skin damaged and preparation side according to claim 1
Method, it is characterised in that the traditional Chinese powder medicine preparation method is by by the treatment burn and scald skin damaged
The Chinese medicine material that Chinese medicine paste formulation is weighed is ground into smalls jointly, crosses 120 mesh sieves and takes, sterilization sealing,
Prepare the Chinese medicine of the external-used burn and scald treating skin damaged of the Chinese medicine paste formulation of the treatment burn and scald skin damaged
Powder.
6. a kind of Chinese medicine paste formulation for treating burn and scald skin damaged and preparation side according to claim 1
Method, it is characterised in that the Traditional Chinese medicine tincture preparation preparation method is by by the treatment burn and scald skin damaged
The Chinese medicine material mixture that Chinese medicine paste formulation is weighed is put into 75% alcohol and sealed, and immersion 20th is
Prepare the Traditional Chinese medicine tincture of the external-used burn and scald treating skin damaged of the Chinese medicine paste formulation of the treatment burn and scald skin damaged
Agent.
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Cited By (1)
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| CN108992581A (en) * | 2018-09-29 | 2018-12-14 | 湖南省善恩祥药业有限公司 | A kind of traditional Chinese medicinal ointment and preparation method thereof for treating skin lesion |
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| CN108992581A (en) * | 2018-09-29 | 2018-12-14 | 湖南省善恩祥药业有限公司 | A kind of traditional Chinese medicinal ointment and preparation method thereof for treating skin lesion |
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