CN104940627A - Traditional Chinese medicine composition for promoting wound healing, and preparation method of traditional Chinese medicine composition - Google Patents
Traditional Chinese medicine composition for promoting wound healing, and preparation method of traditional Chinese medicine composition Download PDFInfo
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- CN104940627A CN104940627A CN201510342548.9A CN201510342548A CN104940627A CN 104940627 A CN104940627 A CN 104940627A CN 201510342548 A CN201510342548 A CN 201510342548A CN 104940627 A CN104940627 A CN 104940627A
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Abstract
The invention belongs to the technical field of traditional Chinese medicines, and particularly discloses a traditional Chinese medicine composition for promoting wound healing, and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicinal materials in parts by weight: 8-17 parts of nux vomica, 3-9 parts of clove, 5-15 parts of rhizoma arisaematis, 5-15 parts of cuttlebone, 6-18 parts of rhizoma bletillae, 6-18 parts of folium callicarpae pedunculatae, 3-9 parts of coptis root, 1-6 parts of cassia bark, 1-6 parts of herba lycopi, 1-6 parts of semen persicae and 100-400 parts of sesame oil. The traditional Chinese medicine composition for promoting the wound healing has the characteristics of easing a pain, diminishing swelling, healing a sore, promoting tissue regeneration, preventing infection, and remaining no scar after healing.
Description
Technical field
The invention belongs to technical field of Chinese medicines, relate to a kind of wound medication, be specifically related to a kind of Chinese medicine composition promoting wound healing and preparation method thereof
Background technology
The method of process surgical wound has a lot, and different wounds will adopt different processing methods.Usual treatment step is: debridement: with normal saline or hydrogen peroxide, wound face is cleaned out exactly; Sterilization: by iodine tincture, cotton ball soaked in alcohol sterilization wound circumference; The drug of topical application: be coated with Herba Duchesneae Indicae liquid medicine or sprinkle antiinfectious powder on wound face; Wrapping: bind up a wound with antiseptic gauze, for greater safety, after bandaging, then injects to hospital and prevents tetanic tetanus medicine and injection of antibiotics antiinflammatory injection.Current above-mentioned wound processing method, need through repeated multiple times process, and wound healing is slow, and after general wound healing, meeting scar, affects attractive in appearance.
Chinese medicine just has unique advantage to the process of wound from ancient times, and the documents and materials of open report are very many, and that so really commercially can buy is considerably less.Chinese Patent Application No. 201110363593.4 discloses a kind of Chinese medicine composition promoting wound healing after operation, the constitutive material Radix Astragali, Radix Angelicae Sinensis, the Radix Angelicae Dahuricae, Cornu Cervi Degelatinatum, Herba Taraxaci and Radix Glycyrrhizae mainly add in ceramic vessel by certain part by weight by it, add tap water and soak 30 minutes, after boiling, decoct 20 minutes with warm fire again.The invention solves elderly patients' Post operation human body regeneration function low, and the difficult problem that the post-operative wound caused can not heal for a long time.Chinese Patent Application No. 201110256488.0 discloses the Chinese medicine composition promoting plant wound heeling, comprises following component: a) wound liniment; B) dressing; C) Chinese medicinal composition nutritional liquid; There is disinfection, promote the effect of wound healing.Chinese Patent Application No. 201210242782.0 discloses a kind of pharmaceutical composition promoting postoperative wound to heal, and relates to technical field of Chinese medicine.This pharmaceutical composition is formed by the active fraction preparation of following weight portion: Radix Astragali 12-16 part, Cortex Eucommiae 12-16 part, Radix Angelicae Sinensis 8-12 part, Cortex Phellodendri 8-12 part, Radix Puerariae 8-12 part, Sanguis Draxonis 8-12 part, Radix Achyranthis Bidentatae 15-20 part, Aloe 15-20 part, Semen Persicae 15-20 part, Pericarpium Citri Reticulatae 15-20 part, Radix Sophorae Flavescentis 15-20 part, Lignum Sappan 15-20 part, Flos Lonicerae 10-15 part, effectively can promote wound healing, prevention abdominal adhesions.
Summary of the invention
The object of the present invention is to provide a kind of for promoting the Chinese medicine composition of wound healing.The present invention promotes that the Chinese medicine composition of wound healing has analgesia detumescence, expelling pus and promoting granulation, prevention infection, does not stay the feature of cicatrix more.
The object of the present invention is achieved like this:
Promote a Chinese medicine composition for wound healing, be prepared from according to specific weight portion by following Chinese crude drug: Semen Strychni, Flos Caryophylli, Rhizoma Arisaematis, Endoconcha Sepiae, Pseudobulbus Bletillae (Rhizoma Bletillae), Folium Callicarpae Formosanae, Rhizoma Coptidis, Cortex Cinnamomi, Herba Lycopi, Semen Persicae and Oleum sesami.
Preferably, a kind of Chinese medicine composition promoting wound healing, is prepared from by the Chinese crude drug of following weight portion:
Semen Strychni 8-17, Flos Caryophylli 3-9, Rhizoma Arisaematis 5-15, Endoconcha Sepiae 5-15, Pseudobulbus Bletillae (Rhizoma Bletillae) 6-18, Folium Callicarpae Formosanae 6-18, Rhizoma Coptidis 3-9, Cortex Cinnamomi 1-6, Herba Lycopi 1-6, Semen Persicae 1-6 and Oleum sesami 100-400.
As most preferred technique scheme, a kind of Chinese medicine composition promoting wound healing, is prepared from by the Chinese crude drug of following weight portion:
Semen Strychni 10, Flos Caryophylli 6, Rhizoma Arisaematis 6, Endoconcha Sepiae 10, Pseudobulbus Bletillae (Rhizoma Bletillae) 10, Folium Callicarpae Formosanae 10, Rhizoma Coptidis 4, Cortex Cinnamomi 2, Herba Lycopi 2, Semen Persicae 2 and Oleum sesami 120.
Medical material meridian distribution of property and flavor used is as follows:
Semen Strychni: nature and flavor are bitter, temperature; Very toxic.Return liver, spleen channel.Removing obstruction in the collateral to relieve pain, mass dissipating and swelling eliminating.For rheumatoid arthritis stubborn, paralysis and numbness, injury from falling down, ulcer sore pain; Poliomyelitis sequela, rheumatoid arthritis.
Flos Caryophylli: nature and flavor are pungent, temperature.Return spleen, stomach, lung, kidney channel.Warming middle-JIAO to send down the adverse QI, reinforcing the kidney and supporting YANG.For Deficiency and coldness of spleen and stomach, singultus is vomitted, lack of appetite and vomiting, trusted subordinate's cold type of pain, impotence due to deficiency of the kidney.
Rhizoma Arisaematis: nature and flavor are bitter, pungent, temperature; Poisonous.Return lung, liver, spleen channel.Drying dampness to eliminate phlegm, expellings wind and relieving convulsion, mass dissipating and swelling eliminating.For pertinacious phlegm cough, dizziness due to wind-phlegm, middle wind-phlegm is stopped up, facial hemiparalysis, hemiplegia, epilepsy, infantile convulsion, tetanus.Life uses external treatment carbuncle, snake bite and insect sting.
Endoconcha Sepiae: nature and flavor are salty, puckery, temperature.Return spleen, kidney channel.Astringing to arrest bleeding, relieving leukorrhea by astringents, antacid, sore.For acid regurgitation of having a stomachache, hematemesis and epistaxis, metrorrhagia is had blood in stool, emission and spermatorrhea, leucorrhea with red and white discharge; Peptic Ulcers.External treatment bleeding due to trauma, the many pus of skin ulcer.
Pseudobulbus Bletillae (Rhizoma Bletillae): nature and flavor are bitter, sweet, puckery, are slightly cold.Return lung, liver, stomach warp.Astringing to arrest bleeding, detumescence and promoting granulation.Spit blood for hemoptysis, traumatic hemorrhage, sore swollen toxin, chapped skin; Pulmonary tuberculosis hemoptysis, ulcer haemorrhage.
Folium Callicarpae Formosanae: nature and flavor are put down, and taste is micro-pungent, bitter.Return liver, lung, stomach warp.Removing heat from blood astringing to arrest bleeding, dissipating blood stasis removing toxic substances and promoting subsidence of swelling.Hemostasis and anti-inflammation, dissipating blood stasis for subsidence of swelling.For stomach and the expensive infections of duodenum is hemorrhage, traumatic hemorrhage, epistaxis, gingiva bleeding gingival hemorrhage, sprain swell and ache, suppurative skin ulcer, burn, influenza.
Rhizoma Coptidis: nature and flavor are bitter, cold.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood tells nosebleed, conjunctival congestion, and toothache, quenches one's thirst, carbuncle furuncle; External treatment eczema, eczema, auditory meatus is suppurated.
Cortex Cinnamomi: nature and flavor are pungent, sweet, hot greatly.Return kidney, spleen, the heart, Liver Channel.Mend fire supporing yang, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow.For sexual impotence, cold womb, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, dizziness due to yang deficiency, conjunctival congestion pharyngalgia, trusted subordinate's cold type of pain, and deficiency and coldness is vomited and diarrhoea, colic of cold type, renal mass, amenorrhea, dysmenorrhea.
Herba Lycopi: nature and flavor are bitter, pungent, tepor.Return liver, spleen channel.Blood circulation promoting and blood stasis dispelling, line water detumescence.For menoxenia, amenorrhea, dysmenorrhea, postnatal blood stasis is suffered from abdominal pain, edema.
Semen Persicae: nature and flavor bitter, sweet, flat.GUIXIN, liver, large intestine channel.Blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation.For amenorrhea, dysmenorrhea ， WEIJIA mass in the abdomen, injury from falling down, dryness of the intestine constipation.
Oleum sesami: nature and flavor are sweet, cool.Effect of loosening bowel to relieve constipation, removing toxic substances and promoting granulation.
Semen Strychni, Flos Caryophylli, Rhizoma Arisaematis promoting the flow of QI in the collateral by warming the meridian in visible Chinese medicine composition of the present invention, reducing swelling and alleviating pain.Endoconcha Sepiae, Pseudobulbus Bletillae (Rhizoma Bletillae), Folium Callicarpae Formosanae hemostasis and anti-inflammation, expelling pus and promoting granulation, dissipating blood stasis for subsidence of swelling.Rhizoma Coptidis, Cortex Cinnamomi, Herba Lycopi, Semen Persicae eliminating fire and detoxication, blood circulation promoting and blood stasis dispelling, line water detumescence.Oleum sesami plays effect of removing toxic substances and promoting granulation, coordinating the actions of various ingredients in a prescription.Above-mentioned medical material shares both can promoting the flow of QI in the collateral by warming the meridian, reducing swelling and alleviating pain, again can hemostasis and anti-inflammation, and expelling pus and promoting granulation, can alleviate patient pain fast, promotes wound healing, again can invigorating blood circulation of putrefaction removing and tissue regeneration promoting addiction, thus reach make wound fast more after do not stay again effect of cicatrix.
The above-described a kind of Chinese medicine composition promoting wound healing of the present invention, it is characterized in that, it is external preparation.
Preferably, described external preparation is the one in oil preparation or powder or lotion.
As another object of the present invention, the present invention also provides a kind of preparation method promoting the Chinese medicine composition of wound healing, and it comprises following preparation process:
(1) get Semen Strychni, Flos Caryophylli, Rhizoma Arisaematis, Endoconcha Sepiae, Pseudobulbus Bletillae (Rhizoma Bletillae), Folium Callicarpae Formosanae, Rhizoma Coptidis, Cortex Cinnamomi, Herba Lycopi, Semen Persicae respectively, be dried and crushed into the segmentation of 200 mesh sieves.
(2) all taste fine medicinal material powder after step (1) pulverizing are taken by weight respectively.
(3) fine powder mixing step (2) taken, adds Oleum sesami, stirs 30-120 minute, obtain Chinese medicine composition oil preparation of the present invention.
Oil preparation using method of the present invention is easy, only needs by oil preparation uniform application of the present invention on oilpaper, then flap coverage, according to circumstances can change dressings every day 1 time during use; Also or directly wound surface can be smeared with oil preparation of the present invention.
Detailed description of the invention
Be below specific embodiments of the invention, technical scheme of the present invention is done to describing further, but protection scope of the present invention be not limited to these embodiments.Every do not deviate from the present invention's design change or equivalent substituting include within protection scope of the present invention.
Embodiment 1
Prescription (with parts by weight):
Semen Strychni 10, Flos Caryophylli 6, Rhizoma Arisaematis 6, Endoconcha Sepiae 10, Pseudobulbus Bletillae (Rhizoma Bletillae) 10, Folium Callicarpae Formosanae 10, Rhizoma Coptidis 4, Cortex Cinnamomi 2, Herba Lycopi 2, Semen Persicae 2 and Oleum sesami 120.
Preparation method:
(1) get Semen Strychni, Flos Caryophylli, Rhizoma Arisaematis, Endoconcha Sepiae, Pseudobulbus Bletillae (Rhizoma Bletillae), Folium Callicarpae Formosanae, Rhizoma Coptidis, Cortex Cinnamomi, Herba Lycopi, Semen Persicae respectively, be dried and crushed into the segmentation of 200 mesh sieves.
(2) all taste fine medicinal material powder after step (1) pulverizing are taken by weight respectively.
(3) fine powder mixing step (2) taken, adds Oleum sesami, stirs 120 minutes, obtain Chinese medicine composition oil preparation of the present invention.
Embodiment 2
Prescription (with parts by weight):
Semen Strychni 17, Flos Caryophylli 3, Rhizoma Arisaematis 5, Endoconcha Sepiae 15, Pseudobulbus Bletillae (Rhizoma Bletillae) 8, Folium Callicarpae Formosanae 8, Rhizoma Coptidis 9, Cortex Cinnamomi 3, Herba Lycopi 3, Semen Persicae 2 and Oleum sesami 200.
Preparation method:
With embodiment 1.
Embodiment 3
Prescription (with parts by weight):
Baima Semen Strychni 10, Flos Caryophylli 6, Rhizoma Arisaematis 6, Endoconcha Sepiae 6, Pseudobulbus Bletillae (Rhizoma Bletillae) 12, Folium Callicarpae Formosanae 12, Rhizoma Coptidis 3, Cortex Cinnamomi 6, Herba Lycopi 4, Semen Persicae 4 and Oleum sesami 180.
Preparation method:
With embodiment 1.
Embodiment 4
Prescription (with parts by weight):
Baima Semen Strychni 8, Flos Caryophylli 3, Rhizoma Arisaematis 5, Endoconcha Sepiae 15, Pseudobulbus Bletillae (Rhizoma Bletillae) 6, Folium Callicarpae Formosanae 6, Rhizoma Coptidis 3, Cortex Cinnamomi 1, Herba Lycopi 6, Semen Persicae 6 and Oleum sesami 100.
Preparation method:
With embodiment 1.
Embodiment 5
Semen Strychni 17, Flos Caryophylli 5, Rhizoma Arisaematis 5, Endoconcha Sepiae 15, Pseudobulbus Bletillae (Rhizoma Bletillae) 10, Folium Callicarpae Formosanae 18, Rhizoma Coptidis 9, Cortex Cinnamomi 6, Herba Lycopi 6, Semen Persicae 6 and Oleum sesami 200
Preparation method:
With embodiment 1.
Clinical data:
Choose in May ,-2015 in January, 2012 continuously routine the patient 166 that the court's emergency treatment, outpatient service are medical because of traumatic wound.
1. physical data:
166 routine patients are divided into experimental group and matched group at random.
Experimental group 83 example, 10 years old-66 years old age, mean age 31.5.Wherein wound length is less than 5cm person 60 example, and wound length is greater than 5cm person 23 example, and wound depth is person 56 example within 0.5cm, and wound depth is in more than 0.5cm person 27 example.
Matched group 80 example, 9 years old-68 years old age, 32.1 years old mean age.Wherein wound length is less than 5cm person 61 example, and wound length is greater than 5cm person 22 example, and wound depth is person 57 example within 0.5cm, and wound depth is in more than 0.5cm person 26 example.
Two groups of Genders, age, wound location, sewing needle number, wound degrees etc. compare, through X
2inspection, there was no significant difference (P > 0.05), has comparability.
2. Therapeutic Method:
Experimental group: to traumatic wound debridement or after sewing up, with the oil preparation that most preferred technique scheme of the present invention is obtained, flap coverage, changes dressings 1 every day.
Matched group: to traumatic wound debridement or sew up after, with 5% iodophor disinfection wound surface and surrounding skin, apply alcohol gauze, every day change dressings 1 time.
3. experimental result:
3.1 liang of group hemostasis, detumescence, analgesic effects compare.
Table 1 liang group therapeutic effect
| Group | Case load | Bleeding stopping period (min) | Swelling time (h) | Analgesic time (h) |
| Experimental group | 63 | 15.2±5.5 * | 26.8±15.6 * | 8.4±5.9 * |
| Matched group | 63 | 120±30.5 | 98.1±20.7 | 70.5±24.3 |
Remarks:
*represent and compare P < 0.01 with matched group.
Statistical data shows, after experimental group 63 routine patient external application oil preparation of the present invention, can analgesic hemostatic rapidly, and subside a swelling fast.There is pole significant difference compared with traditional treatment method matched group.
3.2 liang of group wound infections, wound healing situations compare.
Table 2 liang group wound infection, wound healing situation example
| Group | Case load | Wound infection (infection rate) | I phase healing (healing rate) | II phase healing (healing rate) |
| Experimental group | 83 | 0(0) | 80(96.4％) * | 3(3.6％) * |
| Matched group | 83 | 5(6.0％) | 55(66.3％) | 28(33.7％) |
*represent and compare P < 0.01 with matched group.
Note: wound infection refers to that needs additionally give antibiotic therapy and maybe must take other treatment means auxiliary treatment.The healing of I phase refers to that tissue repair is based on original cell, and only containing a small amount of fibrous tissue, local is without infecting, and hematoma or necrosis, tissue regeneration processes is rapid, and 26S Proteasome Structure and Function reparation is good.The healing of II phase refers to that tissue defect is large, edge of wound is not whole, trembles out, cannot be neatly involutory, or with the healing of the wound infected.
Table 2 data are visible, and after treatment, none example of experimental group infects, and within average 3 days, take out stitches, I phase healing rate can reach 96.4%, has pole significant difference compared with matched group I phase healing rate 66.3%.Matched group has 5 generations infection in various degree, and within average 5 days, take out stitches, I phase healing rate is only 66.3%, has 5 routine wounds to infect.
After experimental group patient takes out stitches, there are 50 routine patients to select to adhere to continuing to smear oil preparation of the present invention 30 days, have 45 routine patient's cicatrixs to disappear after 30 days, illustrate that oil preparation of the present invention can make patient's cicatrix of more than 90% disappear.
After treatment group patient takes out stitches one month, pay a return visit and find, only have 5 routine patient's cicatrixs to disappear.
Claims (6)
1. promote a Chinese medicine composition for wound healing, it is characterized in that, be prepared from according to specific weight portion by following Chinese crude drug: Semen Strychni, Flos Caryophylli, Rhizoma Arisaematis, Endoconcha Sepiae, Pseudobulbus Bletillae (Rhizoma Bletillae), Folium Callicarpae Formosanae, Rhizoma Coptidis, Cortex Cinnamomi, Herba Lycopi, Semen Persicae and Oleum sesami.
2. a kind of Chinese medicine composition promoting wound healing as claimed in claim 1, is characterized in that, be prepared from by the Chinese crude drug of following weight portion:
Semen Strychni 8-17, Flos Caryophylli 3-9, Rhizoma Arisaematis 5-15, Endoconcha Sepiae 5-15, Pseudobulbus Bletillae (Rhizoma Bletillae) 6-18, Folium Callicarpae Formosanae 6-18, Rhizoma Coptidis 3-9, Cortex Cinnamomi 1-6, Herba Lycopi 1-6, Semen Persicae 1-6 and Oleum sesami 100-400.
3. a kind of Chinese medicine composition promoting wound healing as claimed in claim 1, is characterized in that, be prepared from by the Chinese crude drug of following weight portion:
Semen Strychni 10, Flos Caryophylli 6, Rhizoma Arisaematis 6, Endoconcha Sepiae 10, Pseudobulbus Bletillae (Rhizoma Bletillae) 10, Folium Callicarpae Formosanae 10, Rhizoma Coptidis 4, Cortex Cinnamomi 2, Herba Lycopi 2, Semen Persicae 2 and Oleum sesami 120.
4. a kind of Chinese medicine composition promoting wound healing as claimed in claim 1, it is characterized in that, it is external preparation.
5. a kind of Chinese medicine composition promoting wound healing as claimed in claim 1, is characterized in that described external preparation is oil preparation or powder or lotion.
6. a kind of Chinese medicine composition promoting wound healing as claimed in claim 1, it is characterized in that the preparation method of described oil preparation, it comprises following preparation process:
(1) get Semen Strychni, Flos Caryophylli, Rhizoma Arisaematis, Endoconcha Sepiae, Pseudobulbus Bletillae (Rhizoma Bletillae), Folium Callicarpae Formosanae, Rhizoma Coptidis, Cortex Cinnamomi, Herba Lycopi, Semen Persicae respectively, be dried and crushed into the segmentation of 200 mesh sieves;
(2) all taste fine medicinal material powder after step (1) pulverizing are taken by weight respectively;
(3) fine powder mixing step (2) taken, adds Oleum sesami, stirs 30-120 minute, obtain Chinese medicine composition oil preparation of the present invention.
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Cited By (4)
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| CN105497961A (en) * | 2015-12-28 | 2016-04-20 | 王书美 | Medical film having skin wound repair promoting function and preparation method |
| CN106109854A (en) * | 2016-08-11 | 2016-11-16 | 董加利 | A kind of pharmaceutical composition promoting skin wound healing |
| CN106975095A (en) * | 2017-04-11 | 2017-07-25 | 南阳师范学院 | A kind of antibacterial medical auxiliary material and preparation method thereof |
| CN109350634A (en) * | 2018-12-10 | 2019-02-19 | 河北中医学院 | A kind of Chinese medicine composition and preparation method thereof for promoting wound healing |
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| CN1739697A (en) * | 2005-09-02 | 2006-03-01 | 张国梁 | Externally applied ointment for treating burns and scalds |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105497961A (en) * | 2015-12-28 | 2016-04-20 | 王书美 | Medical film having skin wound repair promoting function and preparation method |
| CN106109854A (en) * | 2016-08-11 | 2016-11-16 | 董加利 | A kind of pharmaceutical composition promoting skin wound healing |
| CN106975095A (en) * | 2017-04-11 | 2017-07-25 | 南阳师范学院 | A kind of antibacterial medical auxiliary material and preparation method thereof |
| CN109350634A (en) * | 2018-12-10 | 2019-02-19 | 河北中医学院 | A kind of Chinese medicine composition and preparation method thereof for promoting wound healing |
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Application publication date: 20150930 |