CN110935011A - A pharmaceutical composition for treating burn - Google Patents

A pharmaceutical composition for treating burn Download PDF

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CN110935011A
CN110935011A CN201911401582.3A CN201911401582A CN110935011A CN 110935011 A CN110935011 A CN 110935011A CN 201911401582 A CN201911401582 A CN 201911401582A CN 110935011 A CN110935011 A CN 110935011A
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chinese
western medicine
medicine composition
treating
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史振英
高海玲
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Abstract

The invention discloses a Chinese and western medicine composition for treating burns, which is characterized by comprising the following components in parts by weight: 5-10 parts of plant polysaccharide, 6-9 parts of pagoda tree bark, 2-5 parts of pine bark, 3-6 parts of motherwort herb, 1-3 parts of potato juice, 4-8 parts of puffball, 5-10 parts of tea oil, 6-12 parts of honeysuckle stem, 1-4 parts of fructus forsythiae, 2-5 parts of earthworm, 5-8 parts of fusidic acid, 4-8 parts of growth factor, 3-6 parts of lithospermum oil and 15-30 parts of rice bran wax. The invention also discloses a preparation method and application of the Chinese and western medicine composition for treating the burn. The Chinese and western medicine composition for treating the burn disclosed by the invention has the advantages of good drug effect, quick response, low toxic and side effects, capability of effectively promoting the growth of new skin, strong antibacterial, anti-inflammatory and anti-infection capabilities, quick wound healing and low scar generation rate.

Description

A pharmaceutical composition for treating burn
Technical Field
The invention relates to the technical field of Chinese and western medicine compound, in particular to a Chinese and western medicine composition for treating burn.
Background
In daily life and work, burn accidents inevitably occur, and the burn is common damage in daily life and production labor and is damage caused by flame, steam, hot liquid, current, chemical substances and the like acting on a human body. Burns can cause damage to the skin of a localized area of the body, and even to the entire body. The high temperature can destroy the skin surface, the wound surface is generally difficult to repair quickly, the local burning pain can directly bring great pain to the patient, and if the patient is not treated in time, serious consequences can be brought, and even the risk of amputation exists. Therefore, the search for highly effective burn treatment drugs is of great importance in alleviating the physical pain and economic burden on patients.
At present, the medicines for treating burn mainly comprise two main types of traditional Chinese medicines and western medicines. Traditional Chinese medicines are increasingly used in various medicines due to their mild properties, but the treatment time is relatively long and the effect is slow. The western medicine has obvious effect and quick response when being used for treating diseases, but has the defects of great side effect and certain influence on human body. Therefore, medical workers begin to research the combination of traditional Chinese medicines and western medicines to achieve the purpose of tonifying and shortening the deficiency and treat the burn diseases. Clinically, common burn treatment medicines such as tinctures are easy to volatilize, need to be repeatedly applied, are easy to stimulate new skins, increase pain of patients and leave scars easily; the treatment effect is not ideal and the cure time is long. In addition, the medicines for treating burn in the prior art have the defects of slow effect, long treatment course and scar and sequelae left after the recovery of severe patients.
The Chinese invention patent with application number of 201711278501.6 relates to a Chinese and western medicine composition for treating burn, which comprises the following Chinese medicines and western medicines in parts by weight: 90-130 parts of heartleaf houttuynia herb, 80-120 parts of ginkgo leaf, 50-100 parts of corn stigma, 1000 parts of sevelamer hydrochloride, 20-40 parts of rutin, 8-20 parts of nacre, 5-20 parts of liquorice, 3-18 parts of centipede, 50-100 parts of tree peony bark, 50-80 parts of spiramycin, 4-20 parts of vitamin E, 50-150 parts of enrofloxacin, 300 parts of dirithromycin 200 and 60-120 parts of oxacillin. The invention can dredge collaterals, relieve pain, clear away heat and toxic material, promote blood circulation, remove blood stasis, remove slough, promote granulation, quickly repair tissue epithelium, has high cure rate, has unique advantages particularly in the aspect of treating hypertension burn patients, does not need to control blood pressure, greatly shortens the cure time, and can be basically synchronous with normal burn patients. However, the curative effect of the Chinese and western medicine composition needs to be further improved, and the toxic and side effects need to be further reduced.
Therefore, the development of a Chinese and western medicine composition for treating the burn, which has the advantages of good treatment effect, quick response, small toxic and side effect, strong anti-inflammation and anti-infection capacity, quick healing and low scar incidence rate, is necessary.
Disclosure of Invention
In view of the above, the invention aims to provide the Chinese and western medicine composition for treating the burn, which has the advantages of good drug effect, quick response, low toxic and side effects, capability of effectively promoting the growth of new skin, strong antibacterial, anti-inflammatory and anti-infection capabilities, quick wound healing and low scar generation rate; meanwhile, the invention also provides a preparation method of the Chinese and western medicine composition for treating the burn, and the preparation method is simple and easy to operate, has low requirements on equipment and reaction conditions, and is suitable for continuous large-scale production.
In order to achieve the purpose, the invention adopts the technical scheme that:
a Chinese and western medicine composition for treating burn is characterized by comprising the following components in parts by weight: 5-10 parts of plant polysaccharide, 6-9 parts of pagoda tree bark, 2-5 parts of pine bark, 3-6 parts of motherwort herb, 1-3 parts of potato juice, 4-8 parts of puffball, 5-10 parts of tea oil, 6-12 parts of honeysuckle stem, 1-4 parts of fructus forsythiae, 2-5 parts of earthworm, 5-8 parts of fusidic acid, 4-8 parts of growth factor, 3-6 parts of lithospermum oil and 15-30 parts of rice bran wax.
Preferably, the Chinese and western medicine composition for treating the burn is characterized by comprising the following components in parts by weight: 8 parts of plant polysaccharide, 7 parts of pagodatree bark, 3 parts of pine bark, 5 parts of motherwort, 2 parts of potato juice, 6 parts of puffball, 6 parts of tea oil, 9 parts of honeysuckle stem, 2 parts of fructus forsythiae, 3 parts of earthworm, 6 parts of fusidic acid, 6 parts of growth factor and 4 parts of lithospermum oil.
Further, the plant polysaccharide is at least one of bamboo leaf polysaccharide, atractylodes macrocephala polysaccharide, pachyman, eucommia polysaccharide and cordyceps polysaccharide.
Further, the Chinese and western medicine composition for treating the burn also comprises 1-4 parts of pumice powder.
Further, the growth factor is at least one of Befushu and Fujifukang.
Further, the Chinese and western medicine composition for treating the burn also comprises 2-5 parts of Arthropoda.
Further, the pagodatree bark, the pine bark, the motherwort, the puffball and the forsythia are all crushed into superfine powder.
Further, the average particle size of the ultrafine powder is 300-500 meshes.
Another object of the present invention is to provide a method for preparing the pharmaceutical composition for treating burns, which comprises the following steps: mixing the components in proportion, grinding and sieving with a 100-mesh and 300-mesh sieve, and stirring at 80-90 ℃ for 30-40 minutes.
The invention also aims to provide the application of the Chinese and western medicine composition for treating the burn in the treatment of the burn.
Further, the application method comprises the following steps: after the wound surface is debrided, the Chinese and western medicine composition for treating burn is evenly coated on sterile gauze, the wound surface is bound up, and the dressing is changed every other day. Eschar grafting is still used for large area III degree burns.
The traditional Chinese medicine of the invention has the following pharmacological basis:
bark of Chinese scholartree: dispelling pathogenic wind and removing dampness, relieving swelling and pain, replenishing blood, invigorating qi, invigorating spleen, nourishing stomach, diminishing inflammation, killing bacteria, and enhancing immunity.
Pine bark: astringe and promote granulation. It is used externally to treat burn, scald and infantile eczema.
Motherwort: is pungent, bitter and cool in flavor, and has the effects of clearing away heat and toxic materials, removing blood stasis, relieving pain, promoting blood circulation, and regulating menstruation.
Potato juice: diminishing inflammation, detoxicating, stopping bleeding, promoting wound healing, and removing wound healing pigment.
Puffball: has pungent and mild flavor, and has effects of clearing away heat and toxic materials, dispelling wind and heat, relieving sore throat, relieving swelling and pain, inhibiting bacteria, and stopping bleeding.
Tea oil: skin caring and moisturizing, speckle removing, acne removing, wrinkle removing, and pain relieving effects.
Honeysuckle stem: sweet, cold and nontoxic, enters heart and lung meridians, and has the functions of clearing away heat and toxic material, dispelling wind and dredging collaterals.
Fructus forsythiae: bitter, flat, nontoxic, and antibacterial, and can inhibit typhoid bacillus, paratyphoid bacillus, Escherichia coli, dysentery bacillus, diphtheria bacillus, Vibrio cholerae, staphylococcus, and streptococcus.
Earthworm: cold in nature, salty in taste, clearing heat, calming liver, relieving asthma, dredging collaterals, and promoting urination.
The medicines are mutually compatible and have the effects of clearing heat and detoxicating, relieving pain, removing putrefaction and promoting granulation, providing nutrition for wound surfaces, promoting blood circulation and accelerating epithelial regeneration.
Adopt the produced beneficial effect of above-mentioned technical scheme to lie in:
(1) the preparation method of the Chinese and western medicine composition for treating the burn provided by the invention is simple and feasible, has low preparation cost and low requirements on equipment and reaction conditions, is suitable for continuous large-scale production, and has higher economic value and social value.
(2) The Chinese and western medicine composition for treating the burn overcomes the defects that the traditional medicine for treating the burn generally has slow effect, long course of treatment and scars and sequelae left after the recovery of severe patients, and has the advantages of good medicine effect, quick effect, low toxic and side effects, capability of effectively promoting the growth of new skin, strong antibacterial, anti-inflammatory and anti-infection capability, quick wound healing and low scar occurrence rate.
(3) The Chinese and western medicine composition for treating the burn, provided by the invention, combines the advantages of traditional Chinese medicines and western medicines, is based on the theory of traditional Chinese medicine, combines the modern medicine technology, treats both symptoms and root causes, has short treatment course and good curative effect, does not leave scars, and has no sequelae such as tissue hyperplasia; the components have synergistic effect, can dredge collaterals, relieve pain, clear away heat and toxic materials, promote blood circulation, remove blood stasis, remove necrotic tissue, promote granulation, quickly repair tissue epithelium, have high cure rate, are not limited by the surrounding environment during treatment, can promote the growth of new skin, promote the quick healing of wounds, and have good antibacterial, anti-inflammatory and anti-infection effects.
(4) According to the traditional Chinese medicine and western medicine composition for treating the burn, the growth factor can promote the healing of the wound surface, the fusidic acid can prevent infection, the lithospermum oil can remove the necrotic tissue and promote tissue regeneration, and the lithospermum oil and the Chinese herbal medicines are matched with each other to play the effects of clearing away heat and toxic materials, relieving pain, removing the necrotic tissue and promoting tissue regeneration, providing nutrition for the wound surface, promoting blood circulation and accelerating epithelial regeneration; the pumice can promote wound healing and new skin growth, and has far infrared ray releasing, blood circulation promoting, health promoting, and wound healing effects without scar left.
Detailed Description
In order to make the technical solutions of the present invention better understood and make the above features, objects, and advantages of the present invention more comprehensible, the present invention is further described with reference to the following examples. The examples are intended to illustrate the invention only and are not intended to limit the scope of the invention.
In the embodiment of the invention, the raw materials are all purchased commercially.
Example 1
A Chinese and western medicine composition for treating burn is characterized by comprising the following components in parts by weight: 5 parts of bamboo leaf polysaccharide, 6 parts of pagodatree bark, 2 parts of pine bark, 3 parts of motherwort, 1 part of potato juice, 4 parts of puffball, 5 parts of tea oil, 6 parts of honeysuckle stem, 1 part of weeping forsythia, 2 parts of earthworm, 5 parts of fusidic acid, 4 parts of Beifushu, 3 parts of lithospermum oil, 15 parts of rice bran wax, 1 part of pumice powder and 2 parts of Baiduobang.
Pulverizing cortex Sophorae, cortex Pini, herba Leonuri, Lasiosphaera Seu Calvatia and fructus forsythiae into superfine powder; the average grain diameter of the superfine powder is 300 meshes.
The preparation method of the Chinese and western medicine composition for treating the burn is characterized by comprising the following steps: mixing the components in proportion, grinding, sieving with a 10 mesh sieve, and stirring at 80 deg.C for 30 min.
The application of the Chinese and western medicine composition for treating the burn in treating the burn; the application method comprises the following steps: after the wound surface is debrided, the Chinese and western medicine composition for treating burn is evenly coated on sterile gauze, the wound surface is bound up, and the dressing is changed every other day. Eschar grafting is still used for large area III degree burns.
Example 2
A Chinese and western medicine composition for treating burn is characterized by comprising the following components in parts by weight: 6.5 parts of atractylodes macrocephala polysaccharide, 7.5 parts of pagoda tree bark, 3.5 parts of pine bark, 4.5 parts of motherwort herb, 2 parts of potato juice, 5 parts of puffball, 6 parts of tea oil, 7 parts of honeysuckle stem, 2 parts of weeping forsythia, 3 parts of earthworm, 6 parts of fusidic acid, 5 parts of Fuji complex, 4 parts of lithospermum oil, 17 parts of rice bran wax, 2 parts of pumice powder and 3 parts of Baiduobang.
Pulverizing cortex Sophorae, cortex Pini, herba Leonuri, Lasiosphaera Seu Calvatia and fructus forsythiae into superfine powder; the average grain diameter of the superfine powder is 350 meshes.
The preparation method of the Chinese and western medicine composition for treating the burn is characterized by comprising the following steps: mixing the components in proportion, grinding, sieving with a 150 mesh sieve, and stirring at 82 deg.C for 33 min.
The application of the Chinese and western medicine composition for treating the burn in treating the burn; the application method comprises the following steps: after the wound surface is debrided, the Chinese and western medicine composition for treating burn is evenly coated on sterile gauze, the wound surface is bound up, and the dressing is changed every other day. Eschar grafting is still used for large area III degree burns.
Example 3
A Chinese and western medicine composition for treating burn is characterized by comprising the following components in parts by weight: 8 parts of pachymaran, 7 parts of pagodatree bark, 3 parts of pine bark, 5 parts of motherwort, 2 parts of potato juice, 6 parts of puffball, 6 parts of tea oil, 9 parts of honeysuckle stem, 2 parts of fructus forsythiae, 3 parts of earthworm, 6 parts of fusidic acid, 6 parts of growth factor, 4 parts of lithospermum oil, 3 parts of pumice powder and 3.5 parts of Podopanan; the growth factor is prepared by mixing Befushu and Fuji compound according to the mass ratio of 3: 5.
Pulverizing cortex Sophorae, cortex Pini, herba Leonuri, Lasiosphaera Seu Calvatia and fructus forsythiae into superfine powder; the average grain diameter of the superfine powder is 400 meshes.
The preparation method of the Chinese and western medicine composition for treating the burn is characterized by comprising the following steps: mixing the components in proportion, grinding, sieving with a 200 mesh sieve, and stirring at 85 deg.C for 35 min.
The application of the Chinese and western medicine composition for treating the burn in treating the burn; the application method comprises the following steps: after the wound surface is debrided, the Chinese and western medicine composition for treating burn is evenly coated on sterile gauze, the wound surface is bound up, and the dressing is changed every other day. Eschar grafting is still used for large area III degree burns.
Example 4
A Chinese and western medicine composition for treating burn is characterized by comprising the following components in parts by weight: 9 parts of plant polysaccharide, 8 parts of pagodatree bark, 4.5 parts of pine bark, 5 parts of motherwort, 2.8 parts of potato juice, 7 parts of puffball, 9 parts of tea oil, 11 parts of honeysuckle stem, 3.5 parts of weeping forsythia, 4.5 parts of earthworm, 7.5 parts of fusidic acid, 7 parts of Fuji compound, 5.5 parts of lithospermum oil and 28 parts of rice bran wax; the plant polysaccharide is prepared by mixing bamboo leaf polysaccharide, bighead atractylodes rhizome polysaccharide, pachyman, eucommia polysaccharide and cordyceps polysaccharide according to a mass ratio of 1:1:2:3: 1.
Pulverizing cortex Sophorae, cortex Pini, herba Leonuri, Lasiosphaera Seu Calvatia and fructus forsythiae into superfine powder; the average grain diameter of the superfine powder is 450 meshes.
The preparation method of the Chinese and western medicine composition for treating the burn is characterized by comprising the following steps: mixing the components in proportion, grinding, sieving with a 280-mesh sieve, and stirring at 88 deg.C for 38 min.
The application of the Chinese and western medicine composition for treating the burn in treating the burn; the application method comprises the following steps: after the wound surface is debrided, the Chinese and western medicine composition for treating burn is evenly coated on sterile gauze, the wound surface is bound up, and the dressing is changed every other day. Eschar grafting is still used for large area III degree burns.
Example 5
A Chinese and western medicine composition for treating burn is characterized by comprising the following components in parts by weight: 10 parts of eucommia polysaccharide, 9 parts of pagodatree bark, 5 parts of pine bark, 6 parts of motherwort, 3 parts of potato juice, 8 parts of puffball, 10 parts of tea oil, 12 parts of honeysuckle stem, 4 parts of fructus forsythiae, 5 parts of earthworm, 8 parts of fusidic acid, 8 parts of Beifushu, 6 parts of lithospermum oil, 30 parts of rice bran wax, 4 parts of pumice powder and 5 parts of Baiduobang.
Pulverizing cortex Sophorae, cortex Pini, herba Leonuri, Lasiosphaera Seu Calvatia and fructus forsythiae into superfine powder; the average grain diameter of the superfine powder is 500 meshes.
The preparation method of the Chinese and western medicine composition for treating the burn is characterized by comprising the following steps: mixing the components in proportion, grinding, sieving with a 300 mesh sieve, and stirring at 90 deg.C for 40 min.
The application of the Chinese and western medicine composition for treating the burn in treating the burn; the application method comprises the following steps: after the wound surface is debrided, the Chinese and western medicine composition for treating burn is evenly coated on sterile gauze, the wound surface is bound up, and the dressing is changed every other day. Eschar grafting is still used for large area III degree burns.
Comparative example 1
This example provides a pharmaceutical composition for treating burns, which is formulated and prepared in substantially the same manner as in example 1, except that bamboo leaf polysaccharides, locust tree bark and pine bark are not added.
Comparative example 2
This example provides a pharmaceutical composition for treating burns, which is formulated and prepared in substantially the same manner as in example 1, except that leonurus, potato juice and puffball are not added.
Comparative example 3
This example provides a pharmaceutical composition for treating burns, which is formulated and prepared in substantially the same manner as in example 1, except that tea oil, honeysuckle stem and forsythia fruit are not added.
Comparative example 4
This example provides a pharmaceutical composition for treating burns, which is formulated and prepared in substantially the same manner as in example 1, except that no earthworm and fusidic acid are added.
Comparative example 5
This example provides a pharmaceutical composition for treating burns, which is formulated and prepared in substantially the same manner as in example 1, except that pumice powder is not added.
To further illustrate the beneficial technical effects of the embodiments of the present invention, the Chinese and western medicine compositions for treating burns of the embodiments 1 to 5 of the present invention and the comparative examples 1 to 5 were respectively subjected to performance tests, the test results are shown in table 1, and the test methods are as follows: randomly selecting 100 cases of observation objects in each group, wherein each group corresponds to examples 1-5 and comparative examples 1-5, administering the Chinese and western medicine composition for treating the burn to the group, cleaning the wound surface, uniformly coating the Chinese and western medicine composition for treating the burn on a sterile gauze, wrapping the wound surface, and changing the medicine every other day; the medicine is taken 200g each time, 15 days are a treatment course, and after the treatment course, the clinical test result is observed.
The observation objects are all randomly selected patients with deep II-degree burn before taking medicine again; the patient symptoms were as follows: except the burning of the epidermis and all dermal papilla layers, the dermal reticular layer is partially affected, hair follicles and sweat glands positioned in the deep layer of the dermis are still active, after the blister skin is broken or the rotten skin is removed, the wound surface is white and medium-transparent red, blood vessels with alternate red and white colors or with visible tiny embolism, the wound surface has much exudation, obvious edema, slow pain sensation and slight pain in the epilation test.
The treatment criteria are as follows: the wound surface is completely healed. Improvement: most of the wound surface is healed, and the rest wound surface has no obvious infection. And (4) invalidation: the wound surface is not healed ideally or is infected at the same time.
TABLE 1
Group of Cure (human) Improvement (human) Invalid (human) Total effective rate (%)
Example 1 94 5 1 99
Example 2 96 3 1 99
Example 3 97 3 0 100
Example 4 99 1 0 100
Example 5 100 0 0 100
Comparative example 1 83 7 10 90
Comparative example 2 80 7 13 87
Comparative example 3 78 11 11 89
Comparative example 4 81 10 9 91
Comparative example 5 80 13 7 93
As can be seen from Table 1, the Chinese and western medicine composition for treating burns in the embodiment of the invention has better treatment effect and more remarkable clinical symptom improvement effect compared with the comparative example, which is the result of the synergistic effect of the components.
The foregoing shows and describes the general principles and broad features of the present invention and advantages thereof. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.

Claims (10)

1. A Chinese and western medicine composition for treating burn is characterized by comprising the following components in parts by weight: 5-10 parts of plant polysaccharide, 6-9 parts of pagoda tree bark, 2-5 parts of pine bark, 3-6 parts of motherwort herb, 1-3 parts of potato juice, 4-8 parts of puffball, 5-10 parts of tea oil, 6-12 parts of honeysuckle stem, 1-4 parts of fructus forsythiae, 2-5 parts of earthworm, 5-8 parts of fusidic acid, 4-8 parts of growth factor, 3-6 parts of lithospermum oil and 15-30 parts of rice bran wax.
2. The Chinese-western medicine composition for treating burns according to claim 1, which comprises the following components in parts by weight: 8 parts of plant polysaccharide, 7 parts of pagodatree bark, 3 parts of pine bark, 5 parts of motherwort, 2 parts of potato juice, 6 parts of puffball, 6 parts of tea oil, 9 parts of honeysuckle stem, 2 parts of fructus forsythiae, 3 parts of earthworm, 6 parts of fusidic acid, 6 parts of growth factor and 4 parts of lithospermum oil.
3. The composition of claim 1, wherein the plant polysaccharide is at least one of bamboo leaf polysaccharide, rhizoma Atractylodis Macrocephalae polysaccharide, pachyman, eucommia ulmoides polysaccharide, and Cordyceps polysaccharide.
4. The Chinese-western medicine composition for treating burn according to claim 1, wherein the Chinese-western medicine composition for treating burn further comprises 1-4 parts of pumice powder.
5. The composition of claim 1, wherein the growth factor is at least one of Befushu and Fuji.
6. The Chinese-western medicine composition for treating burn according to claim 1, further comprising 2-5 parts of Podoconp.
7. The traditional Chinese and western medicine composition for treating burn according to claim 1, wherein the pagodatree bark, the pine bark, the motherwort herb, the puffball and the forsythia fruit are all crushed into superfine powder.
8. The composition as claimed in claim 1, wherein the superfine powder has an average particle size of 300-500 mesh.
9. A Chinese-western medicine composition for treating burn according to any one of claims 1-8, wherein the preparation method of the Chinese-western medicine composition for treating burn comprises the following steps: mixing the components in proportion, grinding and sieving with a 100-mesh and 300-mesh sieve, and stirring at 80-90 ℃ for 30-40 minutes.
10. Use of a pharmaceutical combination according to any one of claims 1 to 8 for the treatment of burns; the application method comprises the following steps: after the wound surface is debrided, the Chinese and western medicine composition for treating burn is evenly coated on sterile gauze, the wound surface is bound up, and the dressing is changed every other day. Eschar grafting is still used for large area III degree burns.
CN201911401582.3A 2019-12-30 2019-12-30 A pharmaceutical composition for treating burn Withdrawn CN110935011A (en)

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