CN105726962A - Traditional Chinese medicine composition for promoting wound healing and preparation method thereof - Google Patents
Traditional Chinese medicine composition for promoting wound healing and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for promoting wound healing. The traditional Chinese medicine composition comprises the raw materials: 10-20 parts of astragalus membranaceus, 10-20 parts of radix angelicae sinensis, 10-15 parts of rhizoma panacis japonici, 10-15 parts of rhizoma bletillae striatae, 10-15 parts of radix ampelopsis, 8-12 parts of herba euphorbiae humifusae, 8-12 parts of cortex dictamni, 5-10 parts of draconis sanguis, 5-10 parts of radix ranunculi ternati, 5-10 parts of radix salviae miltiorrhizae, 4-8 parts of common bombax flower, 3-6 parts of pillis ophidiae and 3-6 parts of radix rubiae. The invention also discloses a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition of the invention has effects of astringing to stop bleeding, relieving swelling and pain, regenerating tissue to heal wound and realizing sterilization and bacteriostasis effect, can effectively promote wound healing, has a high cure rate, and has high safety and no side effects.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition promoting wound healing and preparation method thereof, belong to technical field of medicine.
Background technology
Wound is function and the integrity division of tissue in health.Operation is treatment disease and the important means of wound clinically, and simultaneously in some vehicle accidents, the skin and flesh wound often resulting in people is serious, needs hemostatic suture wound as early as possible.Therefore promotion wound healing, the medicine of preventing and treating wound infection, favored by surgeon always.
Wound healing refers to the process of more answering after the tissue appearance fractures such as skin and defect.This process is regeneration and the hypertrophy of granulation tissue, the complex combination of cicatrization of various tissue.Easily occur infecting during wound healing, when wound occurs to infect, in wound, microorganism not only causes erythrocyte and hematoblastic destruction in vital movement process and the extracellular toxin being secreted when destroying, but also make thin vessels smooth muscle contraction, spasm, cause blood capillary retardance and local tissue necrosis, have impact on the speed of repair in trauma.
For wound infection, the most with application antibiotic as preventive means, still lack the safely and effectively method of accelerating wound healing.
Summary of the invention
For above-mentioned prior art, it is an object of the invention to provide a kind of Chinese medicine composition for promoting wound healing, this Chinese medicine composition evident in efficacy, safe and reliable, have no side effect, there is wide potential applicability in clinical practice.
For achieving the above object, the present invention uses following technical proposals:
A kind of Chinese medicine composition promoting wound healing, its raw material consists of:
Radix Astragali 10-20 part, Radix Angelicae Sinensis 10-20 part, Rhizoma Panacis Japonici 10-15 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 10-15 part, Radix Ampelopsis 10-15 part, Herba Euphorbiae Humifusae 8-12 part, Cortex Dictamni 8-12 part, Sanguis Draxonis 5-10 part, Radix Ranunculi Ternati 5-10 part, Radix Salviae Miltiorrhizae 5-10 part, Flos Bombacis Malabarici 4-8 part, Periostracum Serpentis 3-6 part, Radix Rubiae 3-6 part.
The Chinese medicine composition for promoting wound healing of the present invention, preferred medicament composing prescription is:
The Radix Astragali 15 parts, Radix Angelicae Sinensis 15 parts, Rhizoma Panacis Japonici 12 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 12 parts, Radix Ampelopsis 12 parts, Herba Euphorbiae Humifusae 10 parts, Cortex Dictamni 10 parts, Sanguis Draxonis 8 parts, Radix Ranunculi Ternati 8 parts, Radix Salviae Miltiorrhizae 6 parts, Flos Bombacis Malabarici 6 parts, Periostracum Serpentis 5 parts, 5 parts of Radix Rubiae.
In said medicine prescription, each taste medicine is the kind that " Chinese Pharmacopoeia " 2010 version () is recorded, and its quality all meets every regulation relevant under each kind item.
The compatibility of Chinese medicine be particular about mutual reinforcement between, make mutually, mutual restraint between two drugs, the mutual-detoxication, conversely, because there is different compatibility relationships, therefore when using the two above Chinese medicine of taste, it is necessary to be allowed a choice, give full play to the compatibility relationship that mutual reinforcement between medicine makes mutually in the mutual inhibition between different Chinese medicine.The present invention, by kinds of traditional Chinese medicines is carried out compatibility, has jointly played the effect promoting wound healing, has had obvious potentiation, given full play to the compatibility relationship that mutual reinforcement between makes mutually between medicine.In medicament composing prescription, the pharmacology analysis of each taste medicine is as follows:
The Radix Astragali: sweet, tepor.Return lung, spleen channel.Tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, promote the production of body fluid and nourish blood, the stagnant blood stasis dispelling of row, expelling pus and toxin by strengthening QI, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, interior-heat quenches one's thirst, blood deficiency and yellow complexion, hemiplegia, and arthralgia pain is numb, and carbuncle difficulty is burst, and bursts for a long time and does not holds back.
Radix Angelicae Sinensis: sweet, acrid, warm.Return liver, the heart, spleen channel.Replenishing and activating blood, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizziness cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, rheumatic arthralgia, injury from falling down, ulcer sores, dryness of the intestine constipation.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.
Rhizoma Panacis Japonici: hardship sweet, micro-, temperature.Return liver, spleen, lung meridian.Dissipating blood stasis stops blooding, reducing swelling and alleviating pain, expelling phlegm for arresting cough, Xu-tonic.Cough spitting of blood for consumptive disease, injury from falling down, cough with copious phlegm is weak after being ill.
Pseudobulbus Bletillae (Rhizoma Bletillae): bitter, sweet, puckery, is slightly cold.Return lung, liver, stomach warp.Astringing to arrest bleeding, detumescence and promoting granulation.For spitting blood, spit blood, traumatic hemorrhage, sore swollen toxin, chapped skin.
Radix Ampelopsis: bitter, is slightly cold.GUIXIN, stomach warp.Heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, expelling pus and promoting granulation.For carbuncle carbuncle on the back, furuncle, scrofula, burn and scald.
Herba Euphorbiae Humifusae: pungent, flat.Return liver, large intestine channel.Heat-clearing and toxic substances removing, cooling blood for hemostasis, dampness removing jaundice eliminating.For dysentery, have loose bowels, spitting of blood, hematuria, have blood in stool, metrorrhagia, furuncle carbuncle, jaundice due to damp-heat.
Cortex Dictamni: bitter, cold.Return spleen, stomach, bladder warp.Heat clearing and damp drying, removing toxic substances of dispeling the wind.For damp and hot sore, yellow fluid is dripping, eczema, rubella, scabies skin ulcer leprosy, beriberoid pyretic arthralgia, jaundice dark coloured urine.
Sanguis Draxonis: sweet, salty. flat.GUIXIN, Liver Channel.Invigorate blood circulation analgesic therapy, removing stasis to stop bleeding, promoting tissue regeneration and ulcer healing.For traumatic injury, trusted subordinate's stasis of blood pain, traumatic hemorrhage, skin infection is not held back.
Radix Ranunculi Ternati: sweet, acrid, warm.Return liver, lung meridian.Dissipating phlegm and resolving masses, removing toxic substances and promoting subsidence of swelling.For scrofula sucutaneous nodule, furuncle swelling toxin, snake bite and insect sting.
Radix Salviae Miltiorrhizae: bitter, is slightly cold.GUIXIN, Liver Channel.Blood circulation promoting and blood stasis dispelling, inducing menstruation to relieve menalgia, clear away heart-fire relieving restlessness, removing heat from blood eliminating carbuncle.For obstruction of qi in the chest and cardialgia, gastral cavity abdomen hypochondriac pain, abdominal mass accumulation, pyretic arthralgia pain, dysphoria and insomnia, menoxenia, dysmenorrhea amenorrhea, skin infection swells and ache.
Flos Bombacis Malabarici: sweet, light is cool.Return large intestine channel.Clearing away heat-damp and promoting diuresis, removing toxic substances.For having loose bowels, dysentery, hemorrhoid, hemorrhage.
Periostracum Serpentis: salty, sweet is flat.Return Liver Channel.Dispel the wind, arresting convulsion, nebula removing, removing toxic substances.For infantile convulsion, tic spasm, cataracta, sore throat, treat swollen, skin pruritus.
Radix Rubiae: bitter, cold.Return Liver Channel.Removing heat from blood, blood stasis dispelling, hemostasis, stimulate the menstrual flow.For spitting blood, epistaxis, metrorrhagia, traumatic hemorrhage, stasis blocking amenorrhea, arthralgia, tumbling and swelling.
In the medicament composing prescription of the present invention, each drug component is through dialectical compatibility, and in drug action, mutually assistant helps, and the Radix Astragali, Radix Ampelopsis in side, Sanguis Draxonis can be the most collaborative, and gain is complementary, plays the effect of expelling pus and promoting granulation；Rhizoma Panacis Japonici, Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Euphorbiae Humifusae, Radix Ranunculi Ternati, Radix Rubiae compatibility use, and play effect of hemostasis, pain relieving, detumescence, blood stasis dispelling；In side, each taste medicine is applied in combination the function that may also function as bactericidal, various pathogens such as escherichia coli, tubercule bacillus, staphylococcus aureus, Hemolytic streptococcus, Staphylococcus albus etc. had good inhibiting effect, thus prevent wound infection, accelerate the healing of wound, shorten treatment time.
Present invention also offers the preparation method of this Chinese medicine composition, step is as follows:
(1) by the Radix Astragali, Radix Angelicae Sinensis, Rhizoma Panacis Japonici, Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Ampelopsis, Herba Euphorbiae Humifusae, Sanguis Draxonis, Radix Ranunculi Ternati, Radix Salviae Miltiorrhizae, Radix Rubiae mixing, boiling twice, merging filtrate, it is 1.1-1.3(50 DEG C of survey that filtrate is concentrated into relative density), dry, pulverize, sieve, obtain Chinese medical concrete powder；
(2) Cortex Dictamni, Flos Bombacis Malabarici and Periostracum Serpentis are pulverized, sieve, then mix with Chinese medical concrete powder, to obtain final product；
In step (1), the concrete operations of soak by water are: the water adding 8-10 times of quality carries out decocting for the first time, and decocting time is 1-2h, filters, and the water adding 6-8 times of quality in medicinal residues carries out decocting for the second time, and decocting time is 1-2h.
In step (1), it is dried and uses vacuum drying or lyophilization.
In step (1), after pulverizing, cross 100 mesh sieves.
The Chinese medicine composition of the present invention can further mix with pharmaceutically acceptable adjuvant, makes various pharmaceutical dosage form, such as externally used paste, capsule, tablet, granule, suppository etc..
Pharmaceutically acceptable adjuvant is the customary adjuvant in pharmaceutical preparation, such as disintegrating agent, lubricant, binding agent etc.；But acceptable adjuvant is not limited thereto on Chinese materia medica of the present invention, those skilled in the art think feasible customary adjuvant all within protection scope of the present invention, the present invention does not limits at this.
Preferably, this Chinese medicine composition is prepared as externally used paste by the present invention, and for external application, liniment readily penetrates through, and is directly entered blood, participates in blood circulation.
Beneficial effects of the present invention:
The Chinese medicine composition of the present invention has astringing to arrest bleeding, reducing swelling and alleviating pain, promoting tissue regeneration and ulcer healing, effect of bactericidal, it is possible to effectively facilitate the healing of wound, and cure rate is high, and safety has no side effect.
Detailed description of the invention
Below by instantiation, the present invention will be further elaborated, it should explanation, and its content, merely to explain the present invention, is not defined by the description below.
Embodiment 1
A kind of Chinese medicine composition promoting wound healing:
Formula: the Radix Astragali 10 grams, Radix Angelicae Sinensis 20 grams, Rhizoma Panacis Japonici 10 grams, Pseudobulbus Bletillae (Rhizoma Bletillae) 15 grams, Radix Ampelopsis 10 grams, Herba Euphorbiae Humifusae 12 grams, Cortex Dictamni 8 grams, Sanguis Draxonis 10 grams, Radix Ranunculi Ternati 5 grams, Radix Salviae Miltiorrhizae 10 grams, Flos Bombacis Malabarici 4 grams, Periostracum Serpentis 6 grams, 3 grams of Radix Rubiae.
Preparation method:
(1) weigh the Radix Astragali, Radix Angelicae Sinensis, Rhizoma Panacis Japonici, Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Ampelopsis, Herba Euphorbiae Humifusae, Sanguis Draxonis, Radix Ranunculi Ternati, Radix Salviae Miltiorrhizae, Radix Rubiae, boiling twice by formula ratio, filter and (add 8 times amount water for the first time, decoct 2 hours；Second time adds 6 times amount water, decocts 1.5 hours), merging filtrate, be concentrated into relative density and be 1.2(50 DEG C) extractum, 80 DEG C of drying under reduced pressure, pulverize, mistake 100 mesh sieves, standby；
(2) Cortex Dictamni, Flos Bombacis Malabarici and Periostracum Serpentis are pulverized, cross 100 mesh sieves, then mix with Chinese medical concrete powder, to obtain final product.
Embodiment 2
A kind of Chinese medicine composition promoting wound healing:
Formula: the Radix Astragali 20 grams, Radix Angelicae Sinensis 10 grams, Rhizoma Panacis Japonici 15 grams, Pseudobulbus Bletillae (Rhizoma Bletillae) 10 grams, Radix Ampelopsis 15 grams, Herba Euphorbiae Humifusae 8 grams, Cortex Dictamni 12 grams, Sanguis Draxonis 5 grams, Radix Ranunculi Ternati 10 grams, Radix Salviae Miltiorrhizae 5 grams, Flos Bombacis Malabarici 8 grams, Periostracum Serpentis 3 grams, 6 grams of Radix Rubiae.
Preparation method is with embodiment 1.
Embodiment 3
A kind of Chinese medicine composition promoting wound healing:
Formula: the Radix Astragali 15 grams, Radix Angelicae Sinensis 15 grams, Rhizoma Panacis Japonici 12 grams, Pseudobulbus Bletillae (Rhizoma Bletillae) 12 grams, Radix Ampelopsis 12 grams, Herba Euphorbiae Humifusae 10 grams, Cortex Dictamni 10 grams, Sanguis Draxonis 8 grams, Radix Ranunculi Ternati 8 grams, Radix Salviae Miltiorrhizae 6 grams, Flos Bombacis Malabarici 6 grams, Periostracum Serpentis 5 grams, 5 grams of Radix Rubiae.
Preparation method, with embodiment 1, repeats no more.
Embodiment 4
1. acute toxicity test:
Respectively with body weight be 18～23 grams, the kunming mice 30 of male and female half and half is only as experimental animal, gavage mode is respectively divided into two groups that single administration and three times are administered, the Chinese medicine composition that every time prepared by gavage embodiment of the present invention 1-3, the dosage of mice single administration group is 4.2g (crude drug)/kg, three times are administered (being spaced 4～6 hours) dosage of organizing is 12.8g (crude drug)/kg, observe one week after gastric infusion, all do not find animal dead；Therefore the Chinese medicine acute toxicity of the present invention is low, clinical drug safety.
2. long term toxicity test:
Wistar rat 60 is only divided into 1.2g (crude drug)/kg, 0.6g (crude drug)/kg and 0.2g (crude drug)/kg tri-dosage group, Chinese medicine composition prepared by gavage embodiment 1-3, successive administration 2 months, for 4 ~ 6 times of the clinic administration phase.After being administered 1 month, high dose group and matched group put to death 1/3 animal respectively, measure indices；After being administered 2 months, each dosage group is in addition to staying 1/3 animal respectively and making convalescent period observation, and remaining is all put to death, and measures indices.Observe and mensuration project includes such as outward appearance Signs and behavioral activity, secretions, feces character；The conventional index of blood and biochemical indicator；System postmortem and the content such as organ coefficient and histological examination.
Result shows: increase all without impact to rat continuous oral, food-intake and body weight on rat by various dose.Hepatic and renal function is not all found overt toxicity effect.Routine blood test, blood biochemistry, urine biochemistry and bone marrow sheet etc. are showed no and significantly affect, between each group, compare no significant difference with matched group.
Clinical data:
For the checking Chinese medicine composition prepared of the embodiment of the present invention therapeutic effect to wound healing, the patient selecting 200 examples time to come institute medical because of traumatic wound carries out clinical observation.
1. clinical data:
Patient 200 example that institute is medical within 2012 to 2014, is carried out because of traumatic wound, it is randomly divided into treatment 1 group, treats 2 groups, treat 3 groups and matched group, often organize 50 examples, above patient all bleeds because wound causes open wound, pain is gone to a doctor, and age of four groups, sex, wound classification, damage location, wound degree etc. are without significant difference.
2. Therapeutic Method:
Test group I: use the Chinese medicine composition of the embodiment of the present invention 1 preparation, be prepared as external pulvis according to a conventional method, after traumatic wound debridement and suturing, being sprinkled upon uniformly on wound by the external pulvis of above-mentioned preparation, thickness is advisable with 1-2mm, wrapping, every day changes dressings once, until wound healing is taken out stitches.
Test group II: using the Chinese medicine composition of the embodiment of the present invention 2 preparation, be prepared as external pulvis according to a conventional method, using method is with test group I.
Test group III: using the Chinese medicine composition of the embodiment of the present invention 3 preparation, be prepared as external pulvis according to a conventional method, using method is with test group I.
Matched group: operate by traumatic wound nursing routine, after wound debridement and suturing, applies alcohol gauze, changes common aseptic medical dressing every day 1 time, until wound healing is taken out stitches.
3. therapeutic outcome:
Wound healing, wound infection situation compare:
Table 1 wound healing, wound infection situation comparative result
| Case | Case load | The I phase heals | The II phase heals | Wound infection |
| Test group I | 50 | 45 | 5 | 0 |
| Test group II | 50 | 44 | 6 | 0 |
| Test group III | 50 | 48 | 2 | 0 |
| Matched group | 50 | 35 | 10 | 5 |
Note: the healing of I phase refers to that tissue repair, based on original cell, contains only a small amount of fibrous tissue, local is without infecting, and hematoma or necrosis, tissue regeneration processes is rapid, and 26S Proteasome Structure and Function is repaired good.
The healing of II phase refers to that tissue defect is big, edge of wound is the most whole, trembles out, cannot be the most involutory, or the healing with the wound infected.
In process of the test, all there is not toxic and side effects in each test group, illustrates that the present invention's promotes that the Chinese medicine composition of wound healing is safe and effective.
The above; it is only the present invention preferably detailed description of the invention; but protection scope of the present invention is not limited thereto; any those skilled in the art of being familiar with are in the technical scope that the present invention discloses; according to technical scheme and inventive concept equivalent or change in addition thereof, all should contain within protection scope of the present invention.
Claims (8)
1. the Chinese medicine composition promoting wound healing, it is characterised in that its raw material consists of:
Radix Astragali 10-20 part, Radix Angelicae Sinensis 10-20 part, Rhizoma Panacis Japonici 10-15 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 10-15 part, Radix Ampelopsis 10-15 part, Herba Euphorbiae Humifusae 8-12 part, Cortex Dictamni 8-12 part, Sanguis Draxonis 5-10 part, Radix Ranunculi Ternati 5-10 part, Radix Salviae Miltiorrhizae 5-10 part, Flos Bombacis Malabarici 4-8 part, Periostracum Serpentis 3-6 part, Radix Rubiae 3-6 part.
2. Chinese medicine composition as claimed in claim 1, it is characterised in that its raw material consists of:
The Radix Astragali 15 parts, Radix Angelicae Sinensis 15 parts, Rhizoma Panacis Japonici 12 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 12 parts, Radix Ampelopsis 12 parts, Herba Euphorbiae Humifusae 10 parts, Cortex Dictamni 10 parts, Sanguis Draxonis 8 parts, Radix Ranunculi Ternati 8 parts, Radix Salviae Miltiorrhizae 6 parts, Flos Bombacis Malabarici 6 parts, Periostracum Serpentis 5 parts, 5 parts of Radix Rubiae.
3. the application in preparation promotes the pharmaceutical preparation of wound healing of the Chinese medicine composition described in claim 1 or 2.
4. the preparation method of the Chinese medicine composition described in claim 1 or 2, it is characterised in that step is as follows:
(1) by the Radix Astragali, Radix Angelicae Sinensis, Rhizoma Panacis Japonici, Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Ampelopsis, Herba Euphorbiae Humifusae, Sanguis Draxonis, Radix Ranunculi Ternati, Radix Salviae Miltiorrhizae, Radix Rubiae mixing, boiling, merging filtrate, it is 1.1-1.3 that filtrate is concentrated into relative density, dry, pulverize, and sieves, and obtains Chinese medical concrete powder；
(2) Cortex Dictamni, Flos Bombacis Malabarici and Periostracum Serpentis are pulverized, sieve, then mix with Chinese medical concrete powder, to obtain final product.
5. preparation method as claimed in claim 4, it is characterised in that in step (1), the concrete operations of soak by water are: the water adding 8-10 times of quality carries out decocting for the first time, and decocting time is 1-2h, filters, the water adding 6-8 times of quality in medicinal residues carries out decocting for the second time, and decocting time is 1-2h.
6. preparation method as claimed in claim 4, it is characterised in that in step (1), be dried and use vacuum drying or lyophilization.
7. one kind promote wound healing pharmaceutical preparation, it is characterised in that this pharmaceutical preparation is with the Chinese medicine composition described in claim 1 or 2 as active component.
8. pharmaceutical preparation as claimed in claim 7, it is characterised in that the dosage form of this pharmaceutical preparation is externally used paste, external pulvis, tablet, granule or suppository.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106266290A (en) * | 2016-08-31 | 2017-01-04 | 林丽 | A kind of Genneral Surgery Postoperative Analgesia After and the Chinese medicine for external application promoting healing and preparation method thereof |
| CN107158311A (en) * | 2016-09-22 | 2017-09-15 | 臧明礼 | Treatment human depth burns the pure Chinese medicinal preparation of wound |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1382480A (en) * | 2002-05-15 | 2002-12-04 | 李高霖 | Non-scar plaster for treating trauma and its preparing process and usage |
| CN1454653A (en) * | 2003-01-08 | 2003-11-12 | 杨慈元 | Wound medicine |
| CN1498628A (en) * | 2002-11-05 | 2004-05-26 | 潘福宽 | External burn cream |
| CN1586521A (en) * | 2004-07-23 | 2005-03-02 | 罗培省 | Healing agent for skin wound surface |
| CN1613489A (en) * | 2003-12-19 | 2005-05-11 | 东莞市中医院 | Compound preparation its preparing method and use |
| CN104225258A (en) * | 2014-10-10 | 2014-12-24 | 刘树芹 | Traditional Chinese medicine composition for promoting wound healing |
-
2016
- 2016-02-29 CN CN201610110322.0A patent/CN105726962A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1382480A (en) * | 2002-05-15 | 2002-12-04 | 李高霖 | Non-scar plaster for treating trauma and its preparing process and usage |
| CN1498628A (en) * | 2002-11-05 | 2004-05-26 | 潘福宽 | External burn cream |
| CN1454653A (en) * | 2003-01-08 | 2003-11-12 | 杨慈元 | Wound medicine |
| CN1613489A (en) * | 2003-12-19 | 2005-05-11 | 东莞市中医院 | Compound preparation its preparing method and use |
| CN1586521A (en) * | 2004-07-23 | 2005-03-02 | 罗培省 | Healing agent for skin wound surface |
| CN104225258A (en) * | 2014-10-10 | 2014-12-24 | 刘树芹 | Traditional Chinese medicine composition for promoting wound healing |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106266290A (en) * | 2016-08-31 | 2017-01-04 | 林丽 | A kind of Genneral Surgery Postoperative Analgesia After and the Chinese medicine for external application promoting healing and preparation method thereof |
| CN107158311A (en) * | 2016-09-22 | 2017-09-15 | 臧明礼 | Treatment human depth burns the pure Chinese medicinal preparation of wound |
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