CN105233005A - Traditional Chinese medicine composition for preventing infection of skin at catheter opening of central vein indwelling catheter - Google Patents
Traditional Chinese medicine composition for preventing infection of skin at catheter opening of central vein indwelling catheter Download PDFInfo
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- CN105233005A CN105233005A CN201510799589.0A CN201510799589A CN105233005A CN 105233005 A CN105233005 A CN 105233005A CN 201510799589 A CN201510799589 A CN 201510799589A CN 105233005 A CN105233005 A CN 105233005A
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Abstract
The invention discloses a traditional Chinese medicine composition for preventing infection of the skin at a catheter opening of a central vein indwelling catheter. The traditional Chinese medicine composition is prepared from, by weight parts, 15-20 parts of viola mandshurica, 15-20 parts of climbing groundsel herb, 10-15 parts of ampelopsis japonica, 10-15 parts of cortex dictamni, 10-15 parts of campsis grandiflora, 8-12 parts of cortex albiziae, 8-12 parts of aloe, 5-10 parts of siegesbeckia pubescens, 5-10 parts of rhizoma osmundae, 5-10 parts of fineleaf schizonepeta herb, 3-6 parts of humifuse euphorbia herb and 3-6 parts of dendrobium nobile. The invention further discloses a method for preparing the traditional Chinese medicine composition. The traditional Chinese medicine composition has effects of clearing heat and removing toxicity, promoting circulation and removing stasis, removing slough and promoting growth of tissue regeneration, can effectively prevent infection of the skin at the catheter opening of the central vein indwelling catheter, is safe, and has no toxic or side effect.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition of centre of prevention and cure veins indwelling catheter mouth of pipe skin infection, belong to technical field of medicine.
Background technology
Central venous cattaeter is one of main vascular access of hemodialysis patients.Provisional central vein catheter is the vascular routes of first dialysis, poisoning salvage guide, acute renal failure and internal arteriovenous fistula immaturity person first-selection, and its intubate position mainly contains femoral vein, internal jugular vein and subclavian vein.Document points out that internal jugular vein intubate retention time is no more than 3 weeks, and femoral venous catheter retains and is no more than 5 days, but clinical in be all longer than this requirement because various factors causes most provisional deep venouspuncture to retain the time used, this adds increased the danger of infection.On the other hand, after provisional Central venous catherization, patient cannot have a bath, and skin health situation is poor, and cervical region and groin place skinfold many, easily perspire humidity in local.Factors causes provisional central venous cattaeter mouth of pipe skin easily to infect, wherein femoral vein than internal jugular vein, subclavian vein is easier infects.
At present, often use Mupirocin Ointment ointment and erythromycin ointment is used for the treatment of or prevention center veins indwelling catheter mouth of pipe skin infection clinically, but DeGrain, also can there is certain toxic and side effects in life-time service, and Clinical practice has its limitation (ointment containing ethylene glycol can not be used for conduit prepared by poly urethanes).Therefore, based on this clinical demand, research and develop a kind of containing Chinese medicine ingredients, be applicable to most tube material, the clinical newtype drug of effective centre of prevention and cure veins indwelling catheter mouth of pipe skin infection can have clinical value widely.
Summary of the invention
For above-mentioned prior art, the object of this invention is to provide a kind of Chinese medicine composition for centre of prevention and cure veins indwelling catheter mouth of pipe skin infection, this Chinese medicine composition can the skin infection of the effective centre of prevention and cure veins indwelling catheter mouth of pipe, and safe without toxic side effect.
For achieving the above object, the present invention adopts following technical proposals:
A Chinese medicine composition for centre of prevention and cure veins indwelling catheter mouth of pipe skin infection, its raw material consists of:
Herba Violae 15-20 part, Herba Senecionis Scandentis 15-20 part, Radix Ampelopsis 10-15 part, Cortex Dictamni 10-15 part, Flos Campsis 10-15 part, Cortex Albiziae 8-12 part, Aloe 8-12 Fen ， Herba Siegesbeckiae 5-10 part, Rhizoma Osmundae Japonicae 5-10 part, Herba Schizonepetae 5-10 part, Herba Euphorbiae Humifusae 3-6 part, Herba Dendrobii 3-6 part.
The Chinese medicine composition of centre of prevention and cure veins indwelling catheter mouth of pipe skin infection of the present invention, preferred medicament composing prescription is:
Herba Violae 18 parts, Herba Senecionis Scandentis 18 parts, Radix Ampelopsis 12 parts, Cortex Dictamni 12 parts, Flos Campsis 12 parts, Cortex Albiziae 10 parts, Aloe 10 Fen ， Herba Siegesbeckiae 8 parts, Rhizoma Osmundae Japonicae 8 parts, Herba Schizonepetae 8 parts, Herba Euphorbiae Humifusae 5 parts, Herba Dendrobii 5 parts.
In said medicine prescription, each taste medicine is the kind that " Chinese Pharmacopoeia " 2010 version () is recorded, every regulation that its quality is relevant under all meeting each kind item.
The compatibility of Chinese medicine is particular about mutual reinforcement between, the mutual-assistance, mutual restraint between two drugs, the mutual-detoxication, the mutual inhibition, contrary, owing to there is different compatibility relationships between different Chinese medicine, therefore, when the above Chinese medicine of use two taste, must be allowed a choice, give full play to the compatibility relationship of the mutual reinforcement between mutual-assistance between medicine.The present invention, by kinds of traditional Chinese medicines is carried out compatibility, has jointly played the effect of therapeutic community's veins indwelling catheter mouth of pipe skin infection, has had obvious potentiation, given full play to the compatibility relationship of the mutual reinforcement between mutual-assistance between medicine.In medicament composing prescription, the pharmacology analysis of each taste medicine is as follows:
Herba Violae: bitter, acrid, cold.GUIXIN, Liver Channel.Heat-clearing and toxic substances removing, removing heat from blood is subsided a swelling.For furuncle swelling toxin, carbuncle carbuncle on the back, erysipelas, venom.
Herba Senecionis Scandentis: bitter, cold.Return lung, Liver Channel.Heat-clearing and toxic substances removing, improving eyesight, dampness removing.For carbuncle sore tumefacting virus, cold, fever, conjunctival congestion and swelling pain, dysentery, skin eczema.
Radix Ampelopsis: bitter, is slightly cold.GUIXIN, stomach warp.Heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, expelling pus and promoting granulation.For carbuncle carbuncle on the back, furuncle, scrofula, burn and scald.
Cortex Dictamni: bitter, cold.Return spleen, stomach, urinary bladder channel.Heat clearing and damp drying, removing toxic substances of dispeling the wind.For damp and hot sore, yellow fluid is dripping, eczema, rubella, scabies skin ulcer leprosy, beriberoid pyretic arthralgia, jaundice dark coloured urine.
Flos Campsis: sweet, sour, cold.Return liver, pericardium channel.Promoting blood circulation to restore menstrual flow, cooling blood, expelling wind.For menoxenia, amenorrhea and mass in the abdomen, puerperal swelling of the breast, rubella is rubescent, skin pruritus, acne.
Cortex Albiziae: sweet, flat.GUIXIN, liver, lung meridian.Resolving stagnation for tranquilization, promoting blood circulation and detumescence.For irritability, melancholy insomnia, lung abscess, skin ulcer swells, and falls and flutters the pain of injury.
Aloe: bitter, cold.Return liver, stomach, large intestine channel.Relieving constipation by purgation, purging liver-fire, parasite killing treats infantile malnutrition.For constipation with heat retention, infantile convulsion is twitched, infantile malnutrition, external treatment tinea skin ulcer.
Herba Siegesbeckiae: pungent, bitter, cold.Return liver, kidney channel.Wind-damp dispelling, sharp joint, removing toxic substances.For rheumatic arthralgia, muscles and bones is unable, soreness of the waist and knees, quadriplegia, hemiplegia, rubella eczema.
Rhizoma Osmundae Japonicae: bitter, be slightly cold; Slightly poisonous.Return lung, stomach, Liver Channel.Heat-clearing and toxic substances removing, hemostasis, parasite killing.For epidemic disease poison flu, pyretic toxicity dysentery, carbuncle pyogenic infections from tumour or sore, spit blood, epistaxis, has blood in stool, metrorrhagia, abdominal pain due to worm stagnation.
Herba Schizonepetae: pungent, tepor.Return lung, Liver Channel.Induce sweat loose wind, rash, and disappear skin ulcer.For flu, headache, measles, rubella, skin infection from the beginning of.
Herba Euphorbiae Humifusae: pungent, flat.Return liver, large intestine channel.Heat-clearing and toxic substances removing, cooling blood for hemostasis, dampness removing jaundice eliminating.For dysentery, have loose bowels, spitting of blood, hematuria, has blood in stool, metrorrhagia, furuncle carbuncle, jaundice due to damp-heat.
Herba Dendrobii: sweet, is slightly cold.Return stomach, kidney channel.Reinforcing stomach reg fluid, nourishing YIN and clearing away heat.For calentura Tianjin wound, xerostomia excessive thirst, deficiency of stomach-Yin, lack of appetite is retched, and deficiency-heat is not moved back after being ill, hyperactivity of fire caused by deficiency of YIN, hectic fever due to YIN-deficiency consumptive fever, poor vision, and muscles and bones flaccidity is soft.
In medicament composing prescription of the present invention, each drug component is through dialectical compatibility, and in drug action, assistant helps mutually, plays effect of heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, putrefaction-removing granulation-promoting altogether, fundamentally realizes the treating both the principal and secondary aspects of a disease to central venous cattaeter mouth of pipe skin infection.
Present invention also offers the preparation method of this Chinese medicine composition, step is as follows:
(1) by Herba Violae, Herba Senecionis Scandentis, Radix Ampelopsis, Cortex Dictamni, Aloe, Herba Siegesbeckiae, Rhizoma Osmundae Japonicae, Herba Schizonepetae, Herba Euphorbiae Humifusae mixing, decoct with water twice, merging filtrate, it is 1.1-1.3 (50 DEG C of surveys) that filtrate is concentrated into relative density, dry, pulverize, sieve, obtain Chinese medical concrete powder;
(2) Flos Campsis, Cortex Albiziae and Herba Dendrobii are pulverized, sieve, then mix with Chinese medical concrete powder, to obtain final product;
In step (1), the concrete operations of soak by water are: the water adding 8-10 times of quality carries out first time decoction, and decocting time is 1-2h, filters, and the water adding 6-8 times of quality in medicinal residues again carries out second time and decocts, and decocting time is 1-2h.
In step (1), dry employing vacuum drying or lyophilization.
In step (1), after pulverizing, cross 100 mesh sieves.
Chinese medicine composition of the present invention can further mix with pharmaceutically acceptable adjuvant, makes various pharmaceutical dosage form, as externally used paste, capsule, tablet, granule, suppository etc.
Pharmaceutically acceptable adjuvant is the customary adjuvant in pharmaceutical preparation, as disintegrating agent, lubricant, binding agent etc.; But acceptable adjuvant is not limited thereto on Chinese materia medica of the present invention, those skilled in the art think that feasible customary adjuvant is all within protection scope of the present invention, and the present invention does not limit at this.
Preferably, this Chinese medicine composition is prepared into externally used paste (not using ethylene glycol as drug matrices) by the present invention, and for external application, liniment is easy to penetrate, and directly enters blood, participates in blood circulation.
Beneficial effect of the present invention:
Chinese medicine composition of the present invention has the effect of heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, putrefaction-removing granulation-promoting, can the skin infection of the effective centre of prevention and cure veins indwelling catheter mouth of pipe, and safe without toxic side effect.
Detailed description of the invention
Below by instantiation, the present invention will be further elaborated, should be noted that following explanation is only to explain the present invention, not limiting its content.
Embodiment 1: a kind of Chinese medicine composition of centre of prevention and cure veins indwelling catheter mouth of pipe skin infection:
Formula: Herba Violae 15 grams, Herba Senecionis Scandentis 20 grams, Radix Ampelopsis 10 grams, Cortex Dictamni 15 grams, Flos Campsis 10 grams, Cortex Albiziae 12 grams, Aloe 8 Ke ， Herba Siegesbeckiae 10 grams, Rhizoma Osmundae Japonicae 5 grams, Herba Schizonepetae 10 grams, Herba Euphorbiae Humifusae 3 grams, Herba Dendrobii 6 grams.
Preparation method:
(1) take Herba Violae, Herba Senecionis Scandentis, Radix Ampelopsis, Cortex Dictamni, Aloe, Herba Siegesbeckiae, Rhizoma Osmundae Japonicae, Herba Schizonepetae, Herba Euphorbiae Humifusae by formula ratio, decoct with water twice, filter and (add 8 times of water gagings for the first time, decoct 2 hours; Second time adds 6 times of water gagings, decocts 1.5 hours), merging filtrate, is concentrated into the extractum that relative density is 1.2 (50 DEG C), 80 DEG C of drying under reduced pressure, pulverizes, and crosses 100 mesh sieves, for subsequent use;
(2) Flos Campsis, Cortex Albiziae and Herba Dendrobii are pulverized, cross 100 mesh sieves, then mix with Chinese medical concrete powder, to obtain final product.
Embodiment 2: a kind of Chinese medicine composition of centre of prevention and cure veins indwelling catheter mouth of pipe skin infection:
Formula: Herba Violae 20 grams, Herba Senecionis Scandentis 15 grams, Radix Ampelopsis 15 grams, Cortex Dictamni 10 grams, Flos Campsis 15 grams, Cortex Albiziae 8 grams, Aloe 12 Ke ， Herba Siegesbeckiae 5 grams, Rhizoma Osmundae Japonicae 10 grams, Herba Schizonepetae 5 grams, Herba Euphorbiae Humifusae 6 grams, Herba Dendrobii 3 grams.
Preparation method is with embodiment 1.
Embodiment 3: a kind of Chinese medicine composition of centre of prevention and cure veins indwelling catheter mouth of pipe skin infection:
Formula: Herba Violae 18 grams, Herba Senecionis Scandentis 18 grams, Radix Ampelopsis 12 grams, Cortex Dictamni 12 grams, Flos Campsis 12 grams, Cortex Albiziae 10 grams, Aloe 10 Ke ， Herba Siegesbeckiae 8 grams, Rhizoma Osmundae Japonicae 8 grams, Herba Schizonepetae 8 grams, Herba Euphorbiae Humifusae 5 grams, Herba Dendrobii 5 grams.
Preparation method, with embodiment 1, repeats no more.
Embodiment 4
1. acute toxicity test:
Respectively with body weight be 18 ~ 23 grams, the kunming mice 30 of male and female half and half is only for experimental animal, gavage mode is divided into two groups of single administration and three administrations respectively, Chinese medicine composition prepared by each gavage embodiment of the present invention 1-3, the dosage of mice single administration group is 4.2g (crude drug)/kg, the dosage that three administrations (4 ~ 6 hours, interval) are organized is 12.8g (crude drug)/kg, observe one week after gastric infusion, be discovery animal dead; Therefore Chinese medicine acute toxicity of the present invention is low, clinical drug safety.
2. long term toxicity test:
Wistar rat 60 is only divided into 1.2g (crude drug)/kg, 0.6g (crude drug)/kg and 0.2g (crude drug)/kg tri-dosage group, Chinese medicine composition prepared by gavage embodiment 1-3, successive administration 2 months, is 4 ~ 6 times of the clinical administration phase.Administration is after 1 month, and high dose group and matched group put to death 1/3 animal respectively, measures indices; Administration is after 2 months, and each dosage group is except staying 1/3 animal to do convalescent period respectively and observing, and all the other are all put to death, and measures indices.Observation and mensuration project comprise as outward appearance Signs and behavioral activity, secretions, feces character; The conventional index of blood and biochemical indicator; System postmortem and the content such as organ coefficient and histological examination.
Result shows: by various dose to rat continuous oral, increases all without affecting the food-intake of rat and body weight.Overt toxicity effect is not all found to hepatic and renal function.Obvious impact is showed no on routine blood test, blood biochemistry, urine biochemistry and bone marrow sheet etc., between each group, compares no significant difference with matched group.
Clinical data:
For the Chinese medicine composition prepared of the checking embodiment of the present invention is to the therapeutic effect of central venous cattaeter mouth of pipe skin infection, 200 examples are selected to carry out clinical observation due to central venous cattaeter mouth of pipe skin infection or the patient that closes on infection.
1. clinical data:
Within 2012, it is divided at random treatment 1 group, treats 2 groups, treats 3 groups and matched group, often organize 50 examples, the age, sex etc. of four groups are without significant difference to the medical central venous cattaeter mouth of pipe skin infection of 2014 Nian Lai institutes or close on infected patient 200 example.
2. diagnostic criteria: all cases is all diagnostic criteria by the clinical manifestation of the central venous cattaeter mouth of pipe skin infection provided in " clinical practice guideline of chronic kidney disease and dialysis ".
3. Therapeutic Method:
Test group I: the Chinese medicine composition using the embodiment of the present invention 1 to prepare, is prepared into externally-applied soft ointment, every day 2 times, each 2 ~ 3ml, the direct administration in affected part according to a conventional method.
Test group II: use Chinese medicine composition prepared by the embodiment of the present invention 2, be prepared into externally-applied soft ointment according to a conventional method, using method is with test group I.
Test group III: use Chinese medicine composition prepared by the embodiment of the present invention 3, be prepared into externally-applied soft ointment according to a conventional method, using method is with test group I.
Matched group: affected part coating Mupirocin Ointment, by specification uses.
Viewing duration is stopped using all medicines, advises patient to be careful in one's diet, avoids pungent, and four groups was all 1 course for the treatment of with 15 days, treats statistical result after 2 courses for the treatment of.
4. efficacy assessment standard:
Effective: local redness alleviates or disappears, incrustation or transudate disappear or reduce.Around the greater disease damage of disease damage face, the fracture of old fibrous tissue or collapse, have greyish white epithelial tissue to be formed, and fine particulate or the red granulation tissue growth of strawberry shape are shown in the substrate of disease damage, and disease damage heals gradually.
Invalid: disease damage tissue conditions disappears without change, even increases the weight of.
5. therapeutic outcome:
After Ureteral Calculus, the results are shown in Table 1.
Table 1 clinical treatment outcome
| Case | Case load | Effectively | Invalid | Total effective rate (%) |
| Test group I | 50 | 45 | 5 | 90 |
| Test group II | 50 | 44 | 6 | 88 |
| Test group III | 50 | 48 | 2 | 96 |
| Matched group | 50 | 40 | 10 | 80 |
As can be seen from Table 1, compared with existing medicine, the prevention effect of Chinese medicine composition of the present invention to central venous cattaeter mouth of pipe skin infection is more remarkable.In process of clinical application, all there is not toxicity, side effect in each treatment group, illustrates that Chinese medicine composition of the present invention is safe and effective.
The above; be only the present invention's preferably detailed description of the invention; but protection scope of the present invention is not limited thereto; any those skilled in the art of being familiar with are in the technical scope that the present invention discloses; be equal to according to technical scheme of the present invention and inventive concept thereof and replace or change, all should be encompassed within protection scope of the present invention.
Claims (8)
1. a Chinese medicine composition for centre of prevention and cure veins indwelling catheter mouth of pipe skin infection, is characterized in that, its raw material consists of:
Herba Violae 15-20 part, Herba Senecionis Scandentis 15-20 part, Radix Ampelopsis 10-15 part, Cortex Dictamni 10-15 part, Flos Campsis 10-15 part, Cortex Albiziae 8-12 part, Aloe 8-12 Fen ， Herba Siegesbeckiae 5-10 part, Rhizoma Osmundae Japonicae 5-10 part, Herba Schizonepetae 5-10 part, Herba Euphorbiae Humifusae 3-6 part, Herba Dendrobii 3-6 part.
2. Chinese medicine composition as claimed in claim 1, it is characterized in that, its raw material consists of:
Herba Violae 18 parts, Herba Senecionis Scandentis 18 parts, Radix Ampelopsis 12 parts, Cortex Dictamni 12 parts, Flos Campsis 12 parts, Cortex Albiziae 10 parts, Aloe 10 Fen ， Herba Siegesbeckiae 8 parts, Rhizoma Osmundae Japonicae 8 parts, Herba Schizonepetae 8 parts, Herba Euphorbiae Humifusae 5 parts, Herba Dendrobii 5 parts.
3. the application of the Chinese medicine composition described in claim 1 or 2 in the pharmaceutical preparation of preparation centre of prevention and cure veins indwelling catheter mouth of pipe skin infection.
4. the preparation method of the Chinese medicine composition described in claim 1 or 2, is characterized in that, step is as follows:
(1) by Herba Violae, Herba Senecionis Scandentis, Radix Ampelopsis, Cortex Dictamni, Aloe, Herba Siegesbeckiae, Rhizoma Osmundae Japonicae, Herba Schizonepetae, Herba Euphorbiae Humifusae mixing, twice is decocted with water, merging filtrate, it is 1.1-1.3 that filtrate is concentrated into relative density, dry, pulverize, sieve, obtain Chinese medical concrete powder;
(2) Flos Campsis, Cortex Albiziae and Herba Dendrobii are pulverized, sieve, then mix with Chinese medical concrete powder, to obtain final product.
5. preparation method as claimed in claim 4, it is characterized in that, in step (1), the concrete operations of soak by water are: the water adding 8-10 times of quality carries out first time decoction, decocting time is 1-2h, filter, the water adding 6-8 times of quality in medicinal residues again carries out second time and decocts, and decocting time is 1-2h.
6. preparation method as claimed in claim 4, is characterized in that, in step (1), and dry employing vacuum drying or lyophilization.
7. a pharmaceutical preparation for centre of prevention and cure veins indwelling catheter mouth of pipe skin infection, is characterized in that, this pharmaceutical preparation with the Chinese medicine composition described in claim 1 or 2 for active component.
8. pharmaceutical preparation as claimed in claim 7, it is characterized in that, the dosage form of this pharmaceutical preparation is externally used paste, capsule, tablet, granule or suppository.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105902701A (en) * | 2016-06-29 | 2016-08-31 | 山东大学第二医院 | Traditional Chinese medicine composition for treating infection at outlet of peritoneal dialysis tube |
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| CN102462644A (en) * | 2010-11-01 | 2012-05-23 | 张福深 | Sterilizing skin-cleansing agent and production process thereof |
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- 2015-11-18 CN CN201510799589.0A patent/CN105233005A/en active Pending
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| CN102462644A (en) * | 2010-11-01 | 2012-05-23 | 张福深 | Sterilizing skin-cleansing agent and production process thereof |
| CN103816300A (en) * | 2014-01-21 | 2014-05-28 | 中国人民解放军济南军区联勤部药品仪器检验所 | Traditional Chinese medicine pressurized spray for treating skin disorders or mucosa orifice diseases |
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| CN105902701A (en) * | 2016-06-29 | 2016-08-31 | 山东大学第二医院 | Traditional Chinese medicine composition for treating infection at outlet of peritoneal dialysis tube |
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