CN105326982A - Traditional Chinese medicine preparation for treating plasma cell mastitis and preparation method thereof - Google Patents
Traditional Chinese medicine preparation for treating plasma cell mastitis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating plasma cell mastitis. The traditional Chinese medicine preparation is prepared from a blackend swallowwort root, deer-horn glue, rhizoma corydalis, dandelion, honeysuckle, antelope's horn, radix ranunculi ternati, Chinese angelica, herba lycopi and cordate houttuynia. The invention further discloses a preparation method of the traditional Chinese medicine preparation. When used for treating plasma cell mastitis, the traditional Chinese medicine preparation has the advantages of being good in curative effect, low in cost and high in cure rate, having no adverse reaction and the like. The traditional Chinese medicine preparation can rapidly relieve the plasma cell mastitis state, the preparation technology is simple and convenient, toxic and side effects are small, preparation is easy, the raw materials are low in cost, the preparation method is simple, and the traditional Chinese medicine preparation ahs the good cure effect on plasma cell mastitis, and can be greatly applied to clinical practice.
Description
Technical field
The present invention relates to a kind of medicinal preparation, particularly relate to a kind of Chinese medicine preparation being used for the treatment of plasma cell mastitis and preparation method thereof.
Background technology
Plasma cell mastitis, is duct ectasia again, and the traditional Chinese medical science, acne acute mastitis, is commonly called as conduit inflammation, is called for short slurry breast.Slurry breast is not caused by bacteriological infection, but fatty matter in conduit pile up, excessive, cause chemical irritation and the Immunoreactivity of surrounding catheter, cause a large amount of plasmocyte infiltrating, therefore claim plasma cell mastitis.Recurrent exerbation, forms fistula after ulceration, can secondary bacterial infection, does not heal for a long time.A kind of special mammitis thus.
Plasmacellular mastitis is a kind of chronic non-bacterial inflammation of mammary gland.Because pathological characteristic is complicated and changeable, there is multiple name, as " obiterous mastitis ", " scorching lactational mastitis ", " chronic mastitis ", " mammary duct ectasia ", " acne sample mastitis " etc.Plasma cell mastitis mostly occur in, old women, the peak age is 50 ~ 60 years old, and most patient has inverted nipple deformity.Slurry breast is different from general suppurative mastitis age of sucking, and a lot of people is not familiar with this disease, and he is thought by mistake general bacteriological infection, or mistaken diagnosis is tuberculosis of breast, and the most fearful is mistaken diagnosis is that breast carcinoma cuts breast by mistake.
Suddenly, development is fast in plasma cell mastitis morbidity.It is uncomfortable that patient feels breast local pain, and can touch lump.Stretch under lump is positioned at mammary areola or to a certain quadrant.Lump matter is hard, tough.Surface is in nodal-like, and boundary owes clear, with thoracic wall without adhesion.Some skin of breast have edema, Pericarpium Citri Reticulatae sample, general without General Symptomies such as heatings.Nipple often has edema, Pericarpium Citri Reticulatae sample, general without General Symptomies such as heatings.Nipple often has granulated slag sample thing to secrete, frowziness.A few patients companion nipple discharge are courageous and upright or water sample, and Ipsilateral axillary lymph also can be accompanied to tie enlargement.Late period, lump occurred softening, formed abscess.Flow out after abscess ulceration and be mixed with granulated slag sample pus, and cause areola of breast fistula, so that wound recurrent exerbation, gradually become cicatrix, nipple is just caved in into recessed.About 2010, think relevant with endocrine disturbance and Nervous and Mental Factors more.Lutein secretion reduces, estrogen increases relatively is the major reason of primary disease.
China treats plasma cell mastitis at present and there is no effective mode, clinically adopt antibiotic therapy and treatment by Chinese herbs or excision focus more, although after antibiotic medicine is treated, symptom can respite or disappearance, but the infringement that long-term, high-dose uses antibiotic medicine to produce health is very large.And other mastopathy brought out due to plasma cell mastitis, all can cause huge injury to the psychology of patient and physiology.Although had the open source literature utilizing treatment by Chinese herbs plasma cell mastitis at present, mostly under cure rate, and easily bring out other mastopathy.
Summary of the invention
In order to solve the problem, the invention provides a kind of toxic and side effects little, there is splendid curative effect and the Chinese medicine preparation that cost is low, relapse rate is low to plasma cell mastitis.
The technical solution used in the present invention is: a kind of Chinese medicine preparation for the treatment of plasma cell mastitis, and each component of described Chinese medicine preparation is Radix Cynanchi Atrati, Colla cornus cervi, Rhizoma Corydalis, Herba Taraxaci, Flos Lonicerae, Cornu Saigae Tataricae, Radix Ranunculi Ternati, Radix Angelicae Sinensis, Fructus Terminaliae Billericae, Herba Lycopi, Herba Houttuyniae.
Preferably, the ratio of weight and number of various component is Radix Cynanchi Atrati 25-35 part, Colla cornus cervi 15-25 part, Rhizoma Corydalis 15-25 part, Herba Taraxaci 10-20 part, Flos Lonicerae 10-20 part, Cornu Saigae Tataricae 5-15 part, Radix Ranunculi Ternati 5-15 part, Radix Angelicae Sinensis 5-15 part, Fructus Terminaliae Billericae 5-15 part, Herba Lycopi 5-15 part, Herba Houttuyniae 5-15 part.
Preferred, the ratio of weight and number of various component is Radix Cynanchi Atrati 30-35 part, Colla cornus cervi 20-25 part, Rhizoma Corydalis 20-25 part, Herba Taraxaci 10-15 part, Flos Lonicerae 10-15 part, Cornu Saigae Tataricae 5-10 part, Radix Ranunculi Ternati 5-10 part, Radix Angelicae Sinensis 5-10 part, Fructus Terminaliae Billericae 5-10 part, Herba Lycopi 5-10 part, Herba Houttuyniae 5-10 part.
Wherein, the dosage form of described Chinese medicine preparation is: sublimed preparation, powder, injection, plaster, syrup, oral liquid, suck agent, granule, sugar coated tablet, film coated tablet, capsule.
Present invention also offers the preparation method of above-mentioned Chinese medicine preparation, when the dosage form of described Chinese medicine is capsule, comprising:
The first step, Radix Cynanchi Atrati, Colla cornus cervi, Rhizoma Corydalis are mixed in proportion, with being equivalent to alcohol reflux 2-4 time that mixture quality 2-3 determining alcohol is doubly 70-80%, merging filtrate, concentrating under reduced pressure, drying be ground into powder, subsequently with normal propyl alcohol purification 1-2 time, merge extractive liquid, reclaim under reduced pressure normal propyl alcohol to be concentrated into relative density at 60 DEG C be the mastic of 1.21-1.24, is dryly also ground into powder;
Second step, it is ethanol extraction 2-3 time of 80-90% by Herba Taraxaci, Flos Lonicerae, Cornu Saigae Tataricae, Radix Ranunculi Ternati determining alcohol, merge extractive liquid, concentrating under reduced pressure also carries out drying, is ground into powder, adding the powder after pulverizing relative to its quality is the water dissolution of 2-4 times amount, and static 1-3 hour, filters, filtrate reduced in volume is that at 60 DEG C, relative density is the mastic of 1.21-1.24 and dry, pulverize powdered;
3rd step, be mixed in proportion by remaining component pulverize, decoct with water 2 times, each 2-3 hour, filters respectively, merging filtrate, and filtrate is condensed into mastic and dry, pulverize powdered, and the quality of the water added is 2-4 times of the mixture quality of the 3rd step;
4th step, by above-mentioned powder and starch mixing, carry out pelletization treatment subsequently and drying, obtain compound particles, magnesium stearate is added again in compound particles, described magnesium stearate and described compound particles mass ratio are 0.25-100:0.5-100, obtain capsule 's content, are incapsulated in housing by described capsule 's content and namely obtain capsule.
Present invention also offers the preparation method of above-mentioned Chinese medicine preparation, when the dosage form of described Chinese medicine is injection, comprising:
The first step, Radix Cynanchi Atrati, Colla cornus cervi, Rhizoma Corydalis are mixed in proportion, with being equivalent to alcohol reflux 2-4 time that mixture quality 2-3 determining alcohol is doubly 70-80%, merging filtrate, concentrating under reduced pressure, drying be ground into powder, subsequently with normal propyl alcohol purification 1-2 time, merge extractive liquid, reclaim under reduced pressure normal propyl alcohol to be concentrated into relative density at 60 DEG C be the mastic of 1.21-1.24, is dryly also ground into powder;
Second step, it is ethanol extraction 2-3 time of 80-90% by Herba Taraxaci, Flos Lonicerae, Cornu Saigae Tataricae, Radix Ranunculi Ternati determining alcohol, merge extractive liquid, concentrating under reduced pressure also carries out drying, is ground into powder, adding the powder after pulverizing relative to its quality is the water dissolution of 2-4 times amount, and static 1-3 hour, filters, filtrate reduced in volume is that at 60 DEG C, relative density is the mastic of 1.21-1.24 and dry, pulverize powdered;
3rd step, be mixed in proportion by remaining component pulverize, decoct with water 2 times, each 2-3 hour, filters respectively, merging filtrate, and filtrate is condensed into mastic and dry, pulverize powdered, and the quality of the water added is 2-4 times of the mixture quality of the 3rd step;
4th step, above-mentioned powder is mixed, being dissolved in quality is subsequently mixture 2-4 water doubly, the sodium hydroxide hydrotropy relative to powder quality 5%-15% is added under stirring, filter, to add concentration be the salt acid for adjusting pH value of 1mol/L is 5-6, filter, precipitate for subsequent use, filtrate passes through polyamide column, first wash decontamination with water, be the ethanol elution of 80-90% with determining alcohol subsequently, collect ethanol elution, precipitation determining alcohol is the ethanol extraction 2 times of 80-90%, filter, filtrate and above-mentioned eluent merge, reclaim ethanol, be evaporated to mastic and be spray dried to powder, the powder of acquisition is added relative to its quality 1-2 sodium chloride doubly and water for injection appropriate, the volume of needs is injected water to again further after dissolving, filter, embedding, sterilizing, obtain the injection needed.
Radix Cynanchi Atrati bitter in the mouth, salty, cold in nature, return stomach, liver, kidney channel, cure mainly clearing away heat and cooling blood, inducing diuresis for treating stranguria syndrome ' detoxification sore treatment, for the heating of pathogenic warmth wound battalion, fever due to yin deficiency, hectic fever due to YIN-deficiency consumptive fever, puerperal fever due to deficiency of blood, pyretic stranguria, stranguria with blood, swollen ulcer drug.
Colla cornus cervi is sweet, salty, and temperature, returns kidney, Liver Channel, temperature compensation Liver and kidney, beneficial intensive culture blood.For sexual impotence spermatorrhea, the acid of waist knee joint is cold, asthenia weakness and emaciation, metrostaxis, and hematuria of having blood in stool, carbuncle of yin nature swells and ache.
Rhizoma Corydalis history is loaded in " Kaibao Bencao ", warm in nature, and acrid in the mouth is bitter, enters the heart, spleen, liver, lung, is the quality goods of blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, is especially world-famous for effect of pain relieving.Li Shizhen (1518-1593 A.D.) concludes Rhizoma Corydalis in Compendium of Material Medica " invigorate blood circulation, regulate the flow of vital energy, pain relieving, diuresis " four large effects, and praises highly Rhizoma Corydalis " can the stagnation of QI in promoting the circulation of blood, stasis in gas, therefore specially control upper and lower all pains all over the body ".
Herba Taraxaci nature and flavor are sweet, micro-hardship, cold, return liver, stomach warp, have the effects such as diuresis, cathartic, jaundice eliminating subcutaneous ulcer, function of gallbladder promoting.Control pyretic toxicity, carbuncle, skin infection, abscess of internal organ, conjunctival congestion and swelling pain, damp and hot, the puckery pain of jaundice, dribbling urination, furuncle swelling toxin, plasma cell mastitis, scrofula, toothache, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.Control acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, urinary tract infection etc.
Flos Lonicerae sweet in the mouth, cold in nature, return lung, the heart, stomach warp, heat-clearing and toxic substances removing, wind-heat dissipating.For carbuncle furuncle, sore throat, erysipelas, toxic-heat and blood stasis, anemopyretic cold, epidemic febrile disease is generated heat.
Cornu Saigae Tataricae nature and flavor are salty, cold, and enter liver, heart channel, function cures mainly suppressing the hyperactive liver to relieve the wind syndrome, and heat clearing away is relieving convulsion, removing toxic substances.Control calentura coma convulsion to write from memory, delirium is gone mad; Have a headache dizzy, infantile convulsion is twitched, conjunctivitis.
Radix Ranunculi Ternati nature and flavor are sweet, pungent, warm, and return liver, lung meridian, function cures mainly eliminating stagnation, detumescence., tuberculous lymphadenitis not routed for scrofula.
Radix Angelicae Sinensis sweet in the mouth, pungent, warm in nature, return liver, the heart, spleen channel, can enrich blood, invigorate blood circulation, menstruction regulating and pain relieving, moisturize laxation, all cards of main blood deficiency, menoxenia, amenorrhea, dysmenorrhea, lump in the abdomen knot are poly-, metrorrhagia, asthenia cold abdominalgia, flaccidity syndrome and arthralgia syndrome, numbness of the skin, dryness of the intestine dyschezia, weight, ulcer sores, injury from falling down after bloody dysentery.
Fructus Terminaliae Billericae nature and flavor are sweet, puckery, flat, nature and flavor heat-clearing and toxic substances removing, and convergence is nourished blood, coordinating the actions of various ingredients in a prescription.For various heat symptom-complex, dysentery, grasserie, liver-gallbladder disease is weak after being ill.
Herba Lycopi's nature and flavor are bitter, pungent, and tepor, return liver, spleen channel, function cures mainly blood circulation promoting and blood stasis dispelling, line water detumescence.For menoxenia, amenorrhea, dysmenorrhea, postnatal blood stasis is suffered from abdominal pain, edema.
Herba Houttuyniae nature and flavor are pungent, be slightly cold, and return lung meridian, function cures mainly heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, inducing diuresis for treating stranguria syndrome.For lung abscess vomiting pus, expectorant dyspnea of heat type is coughed, hematodiarrhoea, pyretic stranguria, carbuncle sore tumefacting virus.
Beneficial effect of the present invention:
Relative to the medicine being used for the treatment of plasma cell mastitis of the prior art, adopt Chinese medicinal composition preparation of the present invention can depressed liver-energy dispersing and QI regulating, heat-clearing and toxic substances removing, promoting blood circulation and stopping pain, treatment for plasma cell mastitis has good effect, cost is low, cure rate is high, not easily repeatedly, the advantage such as have no adverse reaction, and targeting is strong, energy is mitigate the disease rapidly, and toxic and side effects is little.The present invention is easy to use, and cheap, easy to use, can create good social value and economic interests.
Detailed description of the invention
Embodiment 1:
(1) treat a Chinese medicine for plasma cell mastitis, formed by following raw material medicaments in part by weight proportioning:
Radix Cynanchi Atrati 30 parts, Colla cornus cervi 25 parts, Rhizoma Corydalis 20 parts, Herba Taraxaci 15 parts, Flos Lonicerae 15 parts, Cornu Saigae Tataricae 10 parts, Radix Ranunculi Ternati 10 parts, Radix Angelicae Sinensis 10 parts, Fructus Terminaliae Billericae 10 parts, Herba Lycopi 5 parts, Herba Houttuyniae 5 parts.
(2) preparation method:
The first step, Radix Cynanchi Atrati, Colla cornus cervi, Rhizoma Corydalis are mixed in proportion, with being equivalent to alcohol reflux 2-4 time that mixture quality 2-3 determining alcohol is doubly 70-80%, merging filtrate, concentrating under reduced pressure, drying be ground into powder, subsequently with normal propyl alcohol purification 1-2 time, merge extractive liquid, reclaim under reduced pressure normal propyl alcohol to be concentrated into relative density at 60 DEG C be the mastic of 1.21-1.24, is dryly also ground into powder;
Second step, it is ethanol extraction 2-3 time of 80-90% by Herba Taraxaci, Flos Lonicerae, Cornu Saigae Tataricae, Radix Ranunculi Ternati determining alcohol, merge extractive liquid, concentrating under reduced pressure also carries out drying, is ground into powder, adding the powder after pulverizing relative to its quality is the water dissolution of 2-4 times amount, and static 1-3 hour, filters, filtrate reduced in volume is that at 60 DEG C, relative density is the mastic of 1.21-1.24 and dry, pulverize powdered;
3rd step, be mixed in proportion by remaining component pulverize, decoct with water 2 times, each 2-3 hour, filters respectively, merging filtrate, and filtrate is condensed into mastic and dry, pulverize powdered, and the quality of the water added is 2-4 times of the mixture quality of the 3rd step;
4th step, by above-mentioned powder and starch mixing, carry out pelletization treatment subsequently and drying, obtain compound particles, magnesium stearate is added again in compound particles, described magnesium stearate and described compound particles mass ratio are 0.25-100:0.5-100, obtain capsule 's content, are incapsulated in housing by described capsule 's content and namely obtain capsule.
Embodiment 2:
(1) treat a Chinese medicine for plasma cell mastitis, formed by following raw material medicaments in part by weight proportioning: with embodiment 1.
(2) preparation method:
The first step, Radix Cynanchi Atrati, Colla cornus cervi, Rhizoma Corydalis are mixed in proportion, with being equivalent to alcohol reflux 2-4 time that mixture quality 2-3 determining alcohol is doubly 70-80%, merging filtrate, concentrating under reduced pressure, drying be ground into powder, subsequently with normal propyl alcohol purification 1-2 time, merge extractive liquid, reclaim under reduced pressure normal propyl alcohol to be concentrated into relative density at 60 DEG C be the mastic of 1.21-1.24, is dryly also ground into powder;
Second step, it is ethanol extraction 2-3 time of 80-90% by Herba Taraxaci, Flos Lonicerae, Cornu Saigae Tataricae, Radix Ranunculi Ternati determining alcohol, merge extractive liquid, concentrating under reduced pressure also carries out drying, is ground into powder, adding the powder after pulverizing relative to its quality is the water dissolution of 2-4 times amount, and static 1-3 hour, filters, filtrate reduced in volume is that at 60 DEG C, relative density is the mastic of 1.21-1.24 and dry, pulverize powdered;
3rd step, be mixed in proportion by remaining component pulverize, decoct with water 2 times, each 2-3 hour, filters respectively, merging filtrate, and filtrate is condensed into mastic and dry, pulverize powdered, and the quality of the water added is 2-4 times of the mixture quality of the 3rd step;
4th step, above-mentioned powder is mixed, being dissolved in quality is subsequently mixture 2-4 water doubly, the sodium hydroxide hydrotropy relative to powder quality 5%-15% is added under stirring, filter, to add concentration be the salt acid for adjusting pH value of 1mol/L is 5-6, filter, precipitate for subsequent use, filtrate passes through polyamide column, first wash decontamination with water, be the ethanol elution of 80-90% with determining alcohol subsequently, collect ethanol elution, precipitation determining alcohol is the ethanol extraction 2 times of 80-90%, filter, filtrate and above-mentioned eluent merge, reclaim ethanol, be evaporated to mastic and be spray dried to powder, the powder of acquisition is added relative to its quality 1-2 sodium chloride doubly and water for injection appropriate, the volume of needs is injected water to again further after dissolving, filter, embedding, sterilizing, obtain the injection needed.
Embodiment 3:
1, acute toxicity test process:
Application ICR mice (Beijing Vital River Experimental Animals Technology Co., Ltd. provides) 40, body weight, at 25-30 gram, carries out acute toxicity testing.Mice is divided into two groups at random, i.e. matched group, administration group, fasting 12 hours before experiment, then Chinese medicine capsules suspension of the present invention (be dissolved in water by capsule and the obtain suspension) gavage as embodiment 1 prepares is given, test determination is carried out to the median lethal dose(LD 50) (LD50) of administration, but has not measured LD
50, because this has been mtd test.Result: with Cmax (60%), maximum dosage-feeding (120ml/kg, in one day, part gives for four times) 100g/kg gavage, be equivalent to crude drug amount 60g/kg, be equivalent to be grown up 300 times (by 75kg) of the daily dosage of clinical plan, none death of mice in seven days, put to death each internal organs of mice anatomic observation and do not find toxic reaction, administration group and control group mice are without any difference.
2, long term toxicity test process:
Experimental agents is set as high, medium and low three dosage by application Wistar rat (Beijing Vital River Experimental Animals Technology Co., Ltd. provides), is respectively capsule 8g/kg, 4g/kg, 2g/kg of embodiment 1 formula.Calculating with dosage 0.1g/kg/ sky-backing by people, is 80 times of people's effective dose, 40 times and 20 times respectively; Separately establish a matched group, continuous gastric infusion 90 days, 180 days and Some Animals drug withdrawal, after 10 days, observe the impact on the every physiology of rat, biochemical indicator.Experimental result shows: by various dose to rat continuous oral 180 days, increases all without affecting the food-intake of rat and body weight.Overt toxicity effect is not all found to hepatic and renal function.Obvious impact is showed no on routine blood test, blood biochemistry, urine biochemistry and bone marrow sheet etc., between each group, compares no significant difference with matched group.
Embodiment 4:
Clinical treatment observation of the present invention is as follows:
(1) female patient 150 example, does not wherein give birth to 120 examples, has given birth to 30 examples.
(2) diagnostic criteria:
Suddenly, development is fast in plasma cell mastitis morbidity.It is uncomfortable that patient feels breast local pain, and can touch lump.Stretch under lump is positioned at mammary areola or to a certain quadrant.Lump matter is hard, tough.Surface is in nodal-like, and boundary is clear, with thoracic wall without adhesion.Some skin of breast have edema, Pericarpium Citri Reticulatae sample, general without General Symptomies such as heatings.Nipple often has edema, Pericarpium Citri Reticulatae sample, general without General Symptomies such as heatings.Nipple often has granulated slag sample thing to secrete, frowziness.A few patients companion nipple discharge are courageous and upright or water sample, and Ipsilateral axillary lymph also can be accompanied to tie enlargement.Late period, lump occurred softening, formed abscess.Flow out after abscess ulceration and be mixed with granulated slag sample pus, and cause areola of breast fistula, so that wound recurrent exerbation, gradually become cicatrix, nipple is just caved in into recessed.
(3) Therapeutic Method: 1 group: adopt capsule 100g as obtained in embodiment 1 preparation method, be divided into 10 parts, every morning, (medicine) being taken before meal was a, within 30 days, was a course for the treatment of, took two courses for the treatment of continuously; 2 groups: adopt injection 100g as obtained in embodiment 2 preparation method, be divided into 10 parts, every morning injects portion on an empty stomach, within 30 days, is a course for the treatment of, injects two courses for the treatment of continuously; Separately establish a matched group.
(4) efficacy assessment standard:
Cure: plasma cell mastitis disease states is controlled, and patient sign improves, and patient health recovers gradually;
Take a turn for the better: plasma cell mastitis disease states alleviates, and progressively takes a turn for the better;
Invalid: not reach improvement standard person.
(5) therapeutic outcome
| Group | Cure | Take a turn for the better | Invalid |
| Matched group | 0 | 15 | 35 |
| 1 group | 44 | 5 | 1 |
| 2 groups | 49 | 1 | 0 |
Above-described embodiment, just in order to technical conceive of the present invention and feature are described, its objective is and is one of ordinary skilled in the art can be understood content of the present invention and implement according to this, can not limit the scope of the invention with this.The change of every equivalence done by the essence of content of the present invention or modification, all should be encompassed in protection scope of the present invention.
Claims (6)
1. treat a Chinese medicine preparation for plasma cell mastitis, it is characterized in that: each component of described Chinese medicine preparation is Radix Cynanchi Atrati, Colla cornus cervi, Rhizoma Corydalis, Herba Taraxaci, Flos Lonicerae, Cornu Saigae Tataricae, Radix Ranunculi Ternati, Radix Angelicae Sinensis, Fructus Terminaliae Billericae, Herba Lycopi, Herba Houttuyniae.
2. Chinese medicine preparation as claimed in claim 1, is characterized in that: the ratio of weight and number of various component is Radix Cynanchi Atrati 25-35 part, Colla cornus cervi 15-25 part, Rhizoma Corydalis 15-25 part, Herba Taraxaci 10-20 part, Flos Lonicerae 10-20 part, Cornu Saigae Tataricae 5-15 part, Radix Ranunculi Ternati 5-15 part, Radix Angelicae Sinensis 5-15 part, Fructus Terminaliae Billericae 5-15 part, Herba Lycopi 5-15 part, Herba Houttuyniae 5-15 part.
3. Chinese medicine preparation as claimed in claim 1, is characterized in that: the ratio of weight and number of various component is Radix Cynanchi Atrati 30-35 part, Colla cornus cervi 20-25 part, Rhizoma Corydalis 20-25 part, Herba Taraxaci 10-15 part, Flos Lonicerae 10-15 part, Cornu Saigae Tataricae 5-10 part, Radix Ranunculi Ternati 5-10 part, Radix Angelicae Sinensis 5-10 part, Fructus Terminaliae Billericae 5-10 part, Herba Lycopi 5-10 part, Herba Houttuyniae 5-10 part.
4. according to any one of claim 1-3, treat the Chinese medicine preparation of plasma cell mastitis, it is characterized in that, the dosage form of described Chinese medicine preparation is: sublimed preparation, powder, injection, plaster, syrup, oral liquid, suck agent, granule, sugar coated tablet, film coated tablet, capsule.
5. according to any one of claim 1-3, treat a preparation method for the Chinese medicine preparation of plasma cell mastitis, it is characterized in that: when the dosage form of described Chinese medicine is capsule, comprising:
The first step, Radix Cynanchi Atrati, Colla cornus cervi, Rhizoma Corydalis are mixed in proportion, with being equivalent to alcohol reflux 2-4 time that mixture quality 2-3 determining alcohol is doubly 70-80%, merging filtrate, concentrating under reduced pressure, drying be ground into powder, subsequently with normal propyl alcohol purification 1-2 time, merge extractive liquid, reclaim under reduced pressure normal propyl alcohol to be concentrated into relative density at 60 DEG C be the mastic of 1.21-1.24, is dryly also ground into powder;
Second step, it is ethanol extraction 2-3 time of 80-90% by Herba Taraxaci, Flos Lonicerae, Cornu Saigae Tataricae, Radix Ranunculi Ternati determining alcohol, merge extractive liquid, concentrating under reduced pressure also carries out drying, is ground into powder, adding the powder after pulverizing relative to its quality is the water dissolution of 2-4 times amount, and static 1-3 hour, filters, filtrate reduced in volume is that at 60 DEG C, relative density is the mastic of 1.21-1.24 and dry, pulverize powdered;
3rd step, be mixed in proportion by remaining component pulverize, decoct with water 2 times, each 2-3 hour, filters respectively, merging filtrate, and filtrate is condensed into mastic and dry, pulverize powdered, and the quality of the water added is 2-4 times of the mixture quality of the 3rd step;
4th step, by above-mentioned powder and starch mixing, carry out pelletization treatment subsequently and drying, obtain compound particles, magnesium stearate is added again in compound particles, described magnesium stearate and described compound particles mass ratio are 0.25-100:0.5-100, obtain capsule 's content, are incapsulated in housing by described capsule 's content and namely obtain capsule.
6. the preparation method of the Chinese medicine preparation of plasma cell mastitis according to any one of claim 1-3, is characterized in that: when the dosage form of described Chinese medicine is injection, comprising:
The first step, Radix Cynanchi Atrati, Colla cornus cervi, Rhizoma Corydalis are mixed in proportion, with being equivalent to alcohol reflux 2-4 time that mixture quality 2-3 determining alcohol is doubly 70-80%, merging filtrate, concentrating under reduced pressure, drying be ground into powder, subsequently with normal propyl alcohol purification 1-2 time, merge extractive liquid, reclaim under reduced pressure normal propyl alcohol to be concentrated into relative density at 60 DEG C be the mastic of 1.21-1.24, is dryly also ground into powder;
Second step, it is ethanol extraction 2-3 time of 80-90% by Herba Taraxaci, Flos Lonicerae, Cornu Saigae Tataricae, Radix Ranunculi Ternati determining alcohol, merge extractive liquid, concentrating under reduced pressure also carries out drying, is ground into powder, adding the powder after pulverizing relative to its quality is the water dissolution of 2-4 times amount, and static 1-3 hour, filters, filtrate reduced in volume is that at 60 DEG C, relative density is the mastic of 1.21-1.24 and dry, pulverize powdered;
3rd step, be mixed in proportion by remaining component pulverize, decoct with water 2 times, each 2-3 hour, filters respectively, merging filtrate, and filtrate is condensed into mastic and dry, pulverize powdered, and the quality of the water added is 2-4 times of the mixture quality of the 3rd step;
4th step, above-mentioned powder is mixed, being dissolved in quality is subsequently mixture 2-4 water doubly, the sodium hydroxide hydrotropy relative to powder quality 5%-15% is added under stirring, filter, to add concentration be the salt acid for adjusting pH value of 1mol/L is 5-6, filter, precipitate for subsequent use, filtrate passes through polyamide column, first wash decontamination with water, be the ethanol elution of 80-90% with determining alcohol subsequently, collect ethanol elution, precipitation determining alcohol is the ethanol extraction 2 times of 80-90%, filter, filtrate and above-mentioned eluent merge, reclaim ethanol, be evaporated to mastic and be spray dried to powder, the powder of acquisition is added relative to its quality 1-2 sodium chloride doubly and water for injection appropriate, the volume of needs is injected water to again further after dissolving, filter, embedding, sterilizing, obtain the injection needed.
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| CN201510873658.8A CN105326982A (en) | 2015-12-02 | 2015-12-02 | Traditional Chinese medicine preparation for treating plasma cell mastitis and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106728247A (en) * | 2016-12-29 | 2017-05-31 | 王勤 | It is a kind of to treat medicine of plasma cell mastitis and preparation method thereof |
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| CN103961544A (en) * | 2013-01-25 | 2014-08-06 | 赵粉娥 | Medicine for treating breast diseases |
| CN105056201A (en) * | 2015-09-14 | 2015-11-18 | 鞠茂秀 | Chinese herba preparation for curing plasma cell mastitis and preparation method thereof |
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| CN103961544A (en) * | 2013-01-25 | 2014-08-06 | 赵粉娥 | Medicine for treating breast diseases |
| CN105056201A (en) * | 2015-09-14 | 2015-11-18 | 鞠茂秀 | Chinese herba preparation for curing plasma cell mastitis and preparation method thereof |
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| 吉宏等: "浆细胞性乳腺炎的中医治疗经验", 《甘肃医药》 * |
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| CN106728247A (en) * | 2016-12-29 | 2017-05-31 | 王勤 | It is a kind of to treat medicine of plasma cell mastitis and preparation method thereof |
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