CN113786451A

CN113786451A - A Chinese medicinal composition for treating gynecological tumor and preparation method thereof

Info

Publication number: CN113786451A
Application number: CN202111294522.3A
Authority: CN
Inventors: 吕向东
Original assignee: Zhejiang Yanghe Health Management Technology Co ltd
Current assignee: Zhejiang Yanghe Health Management Technology Co ltd
Priority date: 2021-11-03
Filing date: 2021-11-03
Publication date: 2021-12-14

Abstract

The invention provides a traditional Chinese medicine composition for treating gynecological tumors and a preparation method thereof, and relates to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition for treating gynecological tumors comprises, by weight, 150-300 parts of manglietia papyrifera, 50-100 parts of deer ear feathers, 80-120 parts of garlic, 30-60 parts of oldenlandia diffusa, 60-100 parts of human placenta, 30-60 parts of frankincense and 40-60 parts of cinnamon. The invention also provides a preparation method of the traditional Chinese medicine composition for treating gynecological tumors. The traditional Chinese medicine composition for treating gynecological tumors has the advantages of high content of beneficial components, certain treatment effect on gynecological tumors such as cervical cancer and endometrial cancer, capability of improving the conditions of patients after gynecological tumor operation and inhibition of cancer cell diffusion.

Description

A Chinese medicinal composition for treating gynecological tumor and preparation method thereof

Technical Field

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating gynecological tumors and a preparation method thereof.

Background

Female genital organs are easy to infect and have active physiological functions, so that tumors can be easily developed. The incidence of gynecological tumors increases year by year and is highly youthful, including but not limited to breast tumors, cervical cancer, ovarian cancer, endometrial cancer, vulvar cancer, and the like. These gynecological tumors pose a serious challenge to the health of women in our country. Most of the existing treatment modes are surgical excision and follow-up treatment is carried out by combining radiotherapy and chemotherapy, but the treatment methods have the defects of large side effect, poor survival quality of patients and the like, and the patients need to bear larger economic pressure.

Disclosure of Invention

The invention aims to provide a traditional Chinese medicine composition for treating gynecological tumors, which can effectively treat the gynecological tumors and has a good effect on body recovery of patients after the gynecological tumors are operated.

Another object of the present invention is to provide a method for preparing the above-mentioned Chinese medicinal composition for treating gynecological tumors, wherein the method extracts the beneficial components from the raw materials in various ways, so that the beneficial components are fully released, and the efficacy of the formula can be significantly improved.

The technical problem to be solved by the invention is realized by adopting the following technical scheme.

On one hand, the embodiment of the application provides a traditional Chinese medicine composition for treating gynecological tumors, which comprises, by weight, 150-300 parts of rubus corchorifolius, 50-100 parts of deer feather, 60-120 parts of garlic, 30-60 parts of hedyotis diffusa, 60-100 parts of human placenta, 30-60 parts of frankincense and 40-60 parts of cinnamon.

On the other hand, the embodiment of the present application provides a preparation method of the aforementioned traditional Chinese medicine composition for treating gynecological tumors, which includes the following steps: crushing the raw materials, extracting by using an ultrasonic-assisted semi-bionic method to obtain a solution I, concentrating the solution I to obtain a concentrated solution, and precipitating the concentrated solution with ethanol to obtain a liquid medicine, namely the traditional Chinese medicine composition for treating gynecological tumors.

In summary, compared with the prior art, the embodiments of the present invention have at least the following advantages or beneficial effects:

the traditional Chinese medicine composition for treating gynecological tumors provided by the embodiment of the invention has a good treatment effect on gynecological tumors, and can effectively inhibit the growth of gynecological tumors. In the formula, the winged balanopsis herb is used for clearing heat and removing toxicity, reducing swelling and resolving masses, stopping bleeding, dissipating stasis of the deer ear feather, reducing swelling and removing toxicity, resisting tumors by garlic and improving the immunity of the organism; the oldenlandia diffusa and the oldenlandia diffusa have the effects of clearing away heat and toxic materials, inducing diuresis to reduce edema, promoting blood circulation to stop pain, the placenta hominis tonifies kidney and essence, benefits qi and nourishes blood, the frankincense regulates qi and promotes blood circulation, stops pain, the cinnamon tonifies fire and helps yang, draws fire to return to original, dispels cold to stop pain, and warms and passes through channels and collaterals. Through reasonable compatibility of the medicines, the whole prescription can achieve the aim of better treating gynecological tumors, relieve pain of patients, inhibit tumor growth and reduce tumors to a certain extent, thereby gradually achieving the aim of treating gynecological tumors.

In addition, according to the preparation method of the traditional Chinese medicine composition for treating gynecological tumors, provided by the invention, the beneficial ingredients in the raw materials are extracted in various ways, so that the beneficial ingredients are fully released, and the efficacy of the formula can be remarkably improved.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.

Embracing the tree lotus: is small epiphytic plant of Clerodendranthus of Polypodiaceae, such as Clerodendranthus Serrati, Benzium japonicum, and Filipendula Ulmaria. The whole herb can be used as a medicine, and can relieve fever, diminish inflammation, expel wind and cold, clear lung heat, relieve cough and stop bleeding. [ EFFECT ] can clear away heat and toxic material, resolve swelling, dissipate nodulation and stop bleeding. [ INDICATIONS ] jaundice due to damp-heat, conjunctival congestion and swelling, suppurative otitis media, parotitis, lymphadenitis, scabies and scabies, and traumatic injury.

The deer ear tail feather: is the whole plant of six-edge chrysanthemum, and the height of six-edge chrysanthemum is 40-100 cm. The stem is upright and multi-branched, and the whole plant is almost glandular hair except the corolla. [ PROPERTIES AND FLAVOUR ] pungent and warm. Enter lung, spleen and bladder meridians. [ FUNCTIONS ] can dispel pathogenic wind, remove dampness, remove stagnation, remove blood stasis, relieve swelling, and remove toxic substance. It is used to treat cough, pain, abdominal pain, dysentery, rheumatic arthralgia, amenorrhea, traumatic injury, furuncle, carbuncle, scrofula, and pruritus due to damp toxin. Modern medicine proves that the medicine contains flavonoid glycoside, phenols, organic acid, amino acid and saccharides, and has the effects of killing and inhibiting bacteria, preventing infection, killing parasite, improving blood circulation, and supplementing water and electrolyte.

Garlic: the allicin is a commonly used condiment in life, contains allicin, and easily permeates phospholipid membranes and erythrocyte membranes to enter cells, so that the allicin interacts with certain intramembrane sulfhydryl compounds to play the pharmacological action of the allicin. In addition, allicin has various pharmacological actions of resisting tumor, preventing cardiovascular and cerebrovascular diseases, resisting aging, resisting microorganisms, resisting ulcer, improving immunity of organism, and the like.

All-grass of blackhead snakehead: herba Hedyotidis Diffusae is a plant of genus Erysia of family Rubiaceae, and has bitter, sweet and cold nature, and has effects of clearing heat and detoxicating, inducing diuresis to reduce edema, promoting blood circulation and relieving pain. The herba Hedyotidis Diffusae contains many chemical components with inhibitory effect on various cancers, such as polysaccharides for lymphosarcoma No. 1 ascites type and Ehrlich ascites carcinoma subcutaneous type; the coumarin has effects in inhibiting cervical cancer l4, sarcoma 180, and liver cancer entity type, and triterpenes can inhibit lymph sarcoma No. 1 ascites type, cervical cancer 14 type, sarcoma 180, and liver cancer entity type. Clinical researches show that stigmasterol, beta-sitosterol, oleanolic acid, ursolic acid, p-coumaric acid and the like can stimulate the proliferation of a reticuloendothelial system and strengthen the capability of phagocyte, and the ursolic acid and the oleanolic acid have the effects of resisting bacteria, diminishing inflammation, resisting cancer, reducing enzyme and the like, inhibit the growth of 180 sarcomas and are effective components for resisting tumors.

Human placenta: the placenta refers to human placenta, and the placenta is sweet in nature, salty and warm in taste, enters lung, heart and kidney channels, and has the effects of tonifying kidney, benefiting essence, benefiting qi and nourishing blood. Modern medical research believes that the placenta contains protein, sugar, calcium, vitamins, immune factors, female hormone, progesterone, steroid hormone, gonadotropin, adrenocorticotropic hormone and the like, can promote the development of mammary gland, uterus, vagina and testis, has a promoting effect on thyroid gland, also has a good effect on tuberculosis, bronchial asthma, anemia and the like, and can prevent measles or relieve symptoms by being ground into powder or being orally taken or clysted.

Frankincense: is resin exuded from bark of Boswellia carterii Birdw of Boswellia of Burseraceae and Boswellia bhauradaijiana Birdw of the same genus. [ PROPERTIES, WESTERN AND GUIJING ] is pungent, bitter and warm. Enter heart, liver and spleen meridians. [ FUNCTIONS AND INDICATIONS ] can regulate qi, promote blood circulation, relieve pain, and remove toxic materials. It is indicated for stagnation of qi and blood, pain in the heart and abdomen, carbuncle, sore, swelling and toxin, traumatic injury, dysmenorrhea, and puerperal pain due to blood stasis.

Cinnamon: is dried bark of Cinnamomum cassia Cassia Presl of Lauraceae. In autumn, the seeds are peeled off and dried in the shade. [ PROPERTIES AND WEIGHT GUIDING GEN ] is pungent, sweet and big-heat. It enters kidney, spleen, heart and liver meridians. [ FUNCTIONS AND INDICATIONS ] can tonify fire, strengthen yang, induce fire to return to original, dispel cold, alleviate pain, and warm and dredge meridians. Can be used for treating sexual impotence, cold womb, cold pain of waist and knee, asthma due to kidney deficiency, floating of deficient yang, giddiness, conjunctival congestion, cold pain of heart and abdomen, vomiting and diarrhea due to deficiency cold, cold hernia, abdominal pain, dysmenorrhea, and amenorrhea.

In some embodiments of the present invention, the traditional Chinese medicine composition for treating gynecological tumors comprises, by weight, 220 parts of comfrey, 80 parts of deer feather, 100 parts of garlic, 50 parts of spreading hedyotis herb, 100 parts of human placenta, 50 parts of frankincense and 50 parts of cinnamon.

In some embodiments of the present invention, the semi-bionic extraction method comprises extracting the pulverized raw material with disodium hydrogen phosphate-citric acid buffer solutions with ph2.0, ph7.5 and ph8.3 sequentially for 30-60 min each time.

In some embodiments of the invention, in the above preparation method, the concentration of the disodium hydrogen phosphate-citric acid buffer solution is 0.1 to 0.4 mol/L.

In some embodiments of the invention, in the above preparation method, the feed-to-liquid ratio of the raw material to the disodium hydrogen phosphate-citric acid buffer solution is 1g (40-50) mL.

In some embodiments of the invention, in the preparation method, ultrasonic-assisted extraction is used in the extraction process, and the power of the ultrasonic is 180-220W.

In some embodiments of the invention, in the above preparation method, the percentage by volume of the ethanol solution used for alcohol precipitation is 75%, and the time for alcohol precipitation is 48 hours.

In some embodiments of the invention, in the above preparation method, 1mL of the concentrated solution is equivalent to 2g of the drug substance.

In some embodiments of the invention, in the preparation method, 1mL of the traditional Chinese medicine composition for treating gynecological tumor is equivalent to 7-8 g of raw material medicines.

The features and properties of the present invention are described in further detail below with reference to examples.

Example 1

The present invention aims to provide a traditional Chinese medicine composition for treating gynecological tumors, which is prepared by the following steps:

the method comprises the following steps: cleaning and air drying flos seu fructus Ludwigiae Caudatae, HERBA, Bulbus Allii, herba Hedyotidis Diffusae, placenta hominis, Olibanum and cortex Cinnamomi to obtain dried flos seu fructus Ludwigiae Caudatae, HERBA, Bulbus Allii, herba Hedyotidis Diffusae, placenta hominis, Olibanum and cortex Cinnamomi;

step two: respectively crushing 220g of dried tree-leaved sweetgum, 80g of six-rowed clover, 100g of garlic, 50g of oldenlandia diffusa, 100g of human placenta, 50g of frankincense and 50g of cinnamon, and mixing to obtain mixed powder;

step three; extracting the mixed powder with 0.1mol/L disodium hydrogen phosphate-citric acid buffer solution with pH of 2.0, 7.5 and 8.3 in sequence, wherein the material-liquid ratio is 1g: extracting for 60min each time by using 50mL of ultrasonic wave with ultrasonic power of 180W and ultrasonic temperature of 65 ℃, combining the three extracting solutions to obtain a first solution, and concentrating the first solution to 1mL containing 2g of crude drugs to obtain a concentrated solution;

step four: precipitating the concentrated solution with 75% vol ethanol for 48 hours, collecting supernatant, and evaporating the supernatant to remove ethanol to obtain liquid medicine, wherein 1mL of the liquid medicine contains 7-8 g of crude drugs, namely the traditional Chinese medicine composition for treating gynecological tumors.

Example 2

step three; extracting the mixed powder with 0.4mol/L disodium hydrogen phosphate-citric acid buffer solution with pH of 2.0, 7.5 and 8.3 in sequence, wherein the material-liquid ratio is 1g: 40mL, extracting for 30min each time, performing ultrasonic assistance at the ultrasonic power of 220W and the ultrasonic temperature of 65 ℃ each time, combining the three extracting solutions to obtain a first solution, and concentrating the first solution to 1mL containing 2g of crude drugs to obtain a concentrated solution;

Example 3

step three; extracting the mixed powder with 0.2mol/L disodium hydrogen phosphate-citric acid buffer solution with pH of 2.0, 7.5 and 8.3 in sequence, wherein the material-liquid ratio is 1g: 45mL, extracting for 40min each time, performing ultrasonic assistance at the ultrasonic power of 200W and the ultrasonic temperature of 65 ℃ each time, combining the three extracting solutions to obtain a first solution, and concentrating the first solution to 1mL containing 2g of crude drugs to obtain a concentrated solution;

Example 4

step two: respectively crushing 270g of dried tree-leaved sweetgum, 100g of six-rowed clover, 80g of garlic, 40g of spreading hedyotis herb, 90g of human placenta, 40g of frankincense and 45g of cinnamon, and mixing to obtain mixed powder;

Example 5

step two: respectively crushing 150g of dried tree-hanging lotus, 50g of six-rowed clover, 120g of garlic, 60g of spreading hedyotis herb, 80g of human placenta, 30g of frankincense and 40g of cinnamon, and mixing to obtain mixed powder;

Example 6

step two: respectively crushing 250g of dried tree-leaved sweetgum, 90g of six-rowed clover, 60g of garlic, 30g of oldenlandia diffusa, 70g of human placenta, 60g of frankincense and 55g of cinnamon, and mixing to obtain mixed powder;

Example 7

step two: respectively crushing 300g of dried tree-hanging lotus, 60g of six-edged grass, 110g of garlic, 55g of spreading hedyotis herb, 60g of human placenta, 50g of frankincense and 60g of cinnamon, and mixing to obtain mixed powder;

It should be noted that, although the foregoing embodiments all prepare the traditional Chinese medicine composition for treating gynecological tumor into a liquid medicine, the traditional Chinese medicine extraction and preparation technology is various, and is not limited to this type of extraction method, and the traditional Chinese medicine composition for treating gynecological tumor provided by the present application may also be prepared into granules, powders, capsules, pills or other available dosage forms as long as the drug effect thereof can be significantly improved. Typical cases are:

case one: female, 51 years old at visit, diagnosed as cervical carcinoma at visit, 3.5cm in diameter, accompanied by irregular vaginal bleeding, listlessness, general soreness and weakness at home, and left no surgical treatment due to large economic burden at home. The traditional Chinese medicine composition provided in the embodiment 3 of the application is used, 10ml of the composition is taken every time, 3 times a day, each medicine is taken for three days, 3 medicines are taken as one treatment course, the interval of each treatment course is 21-22 days, after 3 treatment courses of continuous treatment, a patient feels that the body is weak, the look is improved when the patient comes for a diagnosis, and no vaginal bleeding exists. After 10 treatment courses, color Doppler ultrasound examination is carried out in a hospital, the diameter of the cervical tumor is 2.4cm, color Doppler ultrasound examination is carried out after 9 treatment courses of follow-up treatment, the diameter of the cervical tumor is 1.3cm, no other discomfort is caused around the body, the survival of the tumor with the treatment is suspended, the follow-up visit is carried out within half a year, and the recurrence and the metastasis are avoided after the treatment is suspended for 2 years.

Case two: female, 43 years old, diagnosed as endometrial tumor by biopsy from said Hospital, No operation for personal reason, half a year of conservative treatment at home, low body immunity, twice a month common cold, no appetite, listlessness, general weakness, increased menstrual amount in menstrual period, about two thirds of the increase in period compared with the period without illness, irregular vaginal bleeding in non-menstrual period. The abdomen of the patient feels pain and the appearance becomes thin. The traditional Chinese medicine composition provided in the embodiment 3 of the application is used, 10ml of the composition is taken every time, 3 times a day, each medicine is taken for three days, 3 medicines are taken as one treatment course, each treatment course is 21-22 days apart, after two continuous treatment courses, irregular vaginal bleeding is relieved, abdominal pain is weakened voluntarily, after 5 continuous treatment courses, the abdomen is free of tenderness and irregular vaginal bleeding, the body is gradually improved, the physical strength is gradually normal, after 10 continuous treatment courses, the body is basically the same as that of a normal person, the tumor is not enlarged in hospital auxiliary examination, the composition is stopped after 5 continuous treatment courses, and the composition is healthy and has no obvious discomfort.

Although only two patients are treated until the body is basically normal at present, the traditional Chinese medicine composition for treating gynecological tumors provided by the invention is not represented, and only two treatment cases exist. In practice, the formula is used for treating not-resected cervical cancer and endometrial tumor, but also treating excessive patients after surgical resection and chemotherapy and radiotherapy, including but not limited to cervical cancer, endometrial tumor, ovarian cancer, breast tumor and the like, has a good treatment effect on qi and blood weakness and metastasis and diffusion of tumor cells after chemotherapy and radiotherapy, can remarkably improve qi and blood weakness and low body immunity of patients after chemotherapy and radiotherapy, and can well inhibit possible tumor cell metastasis.

In conclusion, the traditional Chinese medicine composition for treating gynecological tumors provided by the embodiment of the invention has a good treatment effect on gynecological tumors, and can effectively inhibit the growth of gynecological tumors. In the formula, the winged balanopsis herb is used for clearing heat and removing toxicity, reducing swelling and resolving masses, stopping bleeding, dissipating stasis of the deer ear feather, reducing swelling and removing toxicity, resisting tumors by garlic and improving the immunity of the organism; the Hedyotis Diffusae and Hedyotis Diffusa have effects of clearing away heat and toxic materials, promoting urination, relieving swelling, promoting blood circulation, and relieving pain. Placenta hominis has effects of invigorating kidney, replenishing vital essence, invigorating qi, nourishing blood, regulating qi, promoting blood circulation, relieving pain, tonifying fire, supporting yang, guiding fire to primordial qi, dispelling cold, relieving pain, and warming and dredging channels and collaterals. Through reasonable compatibility of the medicines, the whole prescription can achieve the aim of better treating gynecological tumors, relieve pain of patients, inhibit tumor growth and reduce tumors to a certain extent, thereby gradually achieving the aim of treating gynecological tumors.

The embodiments described above are some, but not all embodiments of the invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Claims

1. A traditional Chinese medicine composition for treating gynecological tumors is characterized by comprising, by weight, 150-300 parts of rubus corchorifolius, 50-100 parts of deer ear feathers, 60-120 parts of garlic, 30-60 parts of oldenlandia diffusa, 60-100 parts of placenta hominis, 30-60 parts of frankincense and 40-60 parts of cinnamon.

2. The traditional Chinese medicine composition for treating gynecological tumors according to claim 1, which comprises the following raw materials, by weight, 220 parts of rubus corchorifolius, 80 parts of cornus cervi, 100 parts of garlic, 50 parts of spreading hedyotis herb, 100 parts of human placenta, 50 parts of frankincense and 50 parts of cinnamon.

3. A method for preparing a Chinese medicinal composition for treating gynecological tumors as claimed in claim 1 or 2, comprising the steps of: crushing the raw materials, extracting by using an ultrasonic-assisted semi-bionic method to obtain a solution I, concentrating the solution I to obtain a concentrated solution, and precipitating the concentrated solution with ethanol to obtain a liquid medicine, namely the traditional Chinese medicine composition for treating gynecological tumors.

4. The method according to claim 3, wherein the semi-bionic extraction comprises extracting the pulverized raw material with disodium hydrogen phosphate-citric acid buffer solutions of pH2.0, pH7.5 and pH8.3 for 30-60 min.

5. The method according to claim 4, wherein the concentration of the disodium hydrogen phosphate-citric acid buffer solution is 0.1 to 0.4 mol/L.

6. The preparation method according to claim 5, wherein the feed-to-liquid ratio of the raw material to the disodium hydrogen phosphate-citric acid buffer solution is 1g (40-50) mL.

7. The preparation method of claim 6, wherein ultrasonic-assisted extraction is used in the extraction process, and the power of the ultrasonic is 180-220W.

8. The preparation method according to claim 3, wherein the ethanol precipitation is carried out by using 75% volume of ethanol solution and 48 hours of ethanol precipitation time.

9. The method according to claim 3, wherein 1mL of the concentrate corresponds to 2g of the drug substance.

10. The preparation method according to claim 3, wherein 1mL of the traditional Chinese medicine composition for treating gynecological tumor is equivalent to 7-8 g of raw material medicine.