CN116870072A - Traditional Chinese medicine composition, application, gel and preparation method of gel - Google Patents

Traditional Chinese medicine composition, application, gel and preparation method of gel Download PDF

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CN116870072A
CN116870072A CN202310981091.0A CN202310981091A CN116870072A CN 116870072 A CN116870072 A CN 116870072A CN 202310981091 A CN202310981091 A CN 202310981091A CN 116870072 A CN116870072 A CN 116870072A
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parts
gel
raw materials
chinese medicine
traditional chinese
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陈刚
陈新
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Tongji Medical College of Huazhong University of Science and Technology
Wuhan Polytechnic University
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Tongji Medical College of Huazhong University of Science and Technology
Wuhan Polytechnic University
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/808—Scrophularia (figwort)
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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Abstract

The invention discloses a traditional Chinese medicine composition, application, gel and a preparation method of the gel, wherein the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 10-20 parts of honeysuckle; 7-10 parts of radix scrophulariae; 4-8 parts of Chinese angelica; 4-8 parts of medulla Tetrapanacis; 4-8 parts of honeysuckle stem; 1-3 parts of liquorice; and 1-2 parts of borneol, wherein honeysuckle flower is sweet and cold in nature, is good in heat and toxic materials and is used for treating carbuncle, is a monarch drug, figwort root is used for heat clearing and blood cooling, chinese angelica is used for nourishing blood and activating blood, nourishing blood and nourishing yin to generate new, and removing blood stasis and dredging collaterals and relieving pain, and is a ministerial drug, ricepaperplant pith and honeysuckle stem are used for heat clearing and toxic materials, wind dispelling and dredging collaterals, borneol is used for heat clearing and relieving pain, and liquorice is used for heat clearing and toxic materials and is used for harmonizing various drugs, and is an adjuvant drug, and the whole formula has the effects of nourishing yin and clearing heat, detoxifying and relieving pain.

Description

Traditional Chinese medicine composition, application, gel and preparation method of gel
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition, application, gel and a preparation method of the gel.
Background
The multi-receptor tyrosine kinase inhibitor has dual anti-tumor effect, and can directly inhibit tumor growth on one hand; on the other hand, the preparation can indirectly inhibit the growth of tumor cells by blocking the formation of tumor neovascularization, and is the most common clinical treatment method for tumors at present, and common drugs are as follows: sorafenib, an Luoti, lenvatinib, apatinib, regorafenib, sunitinib, furquitinib, pazopanib, acitinib and the like, and the multi-receptor tyrosine kinase inhibitor can act on a plurality of targets, has high efficiency, good safety and remarkable tumor inhibition effect, and becomes one of important means for tumor treatment.
Hand-foot syndrome is one of the common toxic and side effects of multiple receptor tyrosine kinase inhibitors for treating tumors in recent years, for example, the incidence rate of hand-foot syndrome caused by sorafenib can be up to 40%, and the incidence rate of sunitinib can be up to 20%. Studies have shown that symptoms often occur in the first two cycles after administration, patients often fail to walk due to severe pain, even lose life self-care ability, and thus affect the treatment as desired, in sufficient amounts, and fail to achieve the intended therapeutic purpose. Therefore, finding a treatment method which has reliable curative effect, small side effect and economy for preventing and treating the toxic and side effect has very important clinical significance.
Disclosure of Invention
The invention mainly aims to provide a traditional Chinese medicine composition, application, gel and a preparation method of the gel, which have good effects of treating hand-foot syndrome caused by multi-target tyrosine kinase inhibitor antitumor drugs.
In order to achieve the aim, the invention provides a traditional Chinese medicine composition for treating hand-foot syndrome, which comprises the following raw materials in parts by weight: 10-20 parts of honeysuckle; 7-10 parts of radix scrophulariae; 4-8 parts of Chinese angelica; 4-8 parts of medulla Tetrapanacis; 4-8 parts of honeysuckle stem; 1-3 parts of liquorice; and 1-2 parts of borneol.
Optionally, the raw materials comprise the following components in parts by weight: 10 parts of honeysuckle; 8 parts of radix scrophulariae; 5 parts of Chinese angelica; 5 parts of medulla Tetrapanacis; 5 parts of honeysuckle stem; 3 parts of liquorice; and, 1 part of borneol.
Optionally, mixing all the raw materials to obtain a mixed raw material; the mixed raw materials are soaked, decocted, filtered and concentrated to obtain pasty raw materials.
Optionally, when the mixed raw materials are soaked, the weight ratio of the soaking solution to the mixed raw materials is 10-15:1.
The invention also provides application of the traditional Chinese medicine composition in preparation of medicines for treating hand-foot syndrome.
Optionally, the hand-foot syndrome is hand-foot syndrome caused by multi-target tyrosine kinase inhibitor antitumor drugs.
The invention also provides a gel, which comprises a matrix and the traditional Chinese medicine composition.
Optionally, the mass ratio of the matrix to the traditional Chinese medicine composition is 10-20:1.
optionally, the matrix comprises the following raw materials in parts by weight: 1-5 parts of chitosan; 4-6 parts of glycerol; 1-2 parts of azone; 34-36 parts of ethanol; and 60-70 parts of water.
The invention also provides a preparation method of the gel, which comprises the steps of firstly uniformly mixing water with chitosan, glycerol, azone and ethanol, and then adding the pasty traditional Chinese medicine composition to uniformly mix to obtain the gel.
According to the technical scheme provided by the invention, according to clinical manifestations of hand and foot syndromes caused by multi-target tyrosine kinase inhibitors and the theory of cold and heat in traditional Chinese medicine, the multi-target tyrosine kinase inhibitors are considered to belong to the nature of heat, the heat is easy to cause carbuncles and ulcers, and the medicine toxin flows into meridians to accumulate in hands and feet, the internal depression of the fire toxin, the unsmooth qi movement, the blood stasis and stagnation, and meanwhile, the pathogenic factors of the heat consume qi and fluid to hurt the body fluid, so that symptoms such as skin erythema, ulcers, swelling and pain, desquamation, chapping, hard-knot-like blisters and the like at the tail ends of limbs appear, and the multi-target tyrosine kinase inhibitors belong to the category of 'carbuncles' in traditional Chinese medicine, and 'ling pivot-carbuncles' carry: for treating gangrene, it is indicated for yin-nourishing, heat-clearing, blood-activating and pain-relieving. On the basis, the traditional Chinese medicine composition is proposed: is prepared from flos Lonicerae, radix scrophulariae, radix Angelicae sinensis, medulla Tetrapanacis, caulis Lonicerae, glycyrrhrizae radix, and Borneolum Syntheticum. Honeysuckle flower, flos Lonicerae, sweet in flavor and cold in nature, is good at clearing heat and removing toxicity to treat carbuncle and cellulitis, and is a monarch drug. Radix scrophulariae, has effects of clearing heat and cooling blood, radix Angelicae sinensis, nourishing blood and yin to promote tissue regeneration, removing blood stasis and dredging collaterals to relieve pain, and is used as ministerial drug, the medulla Tetrapanacis and the honeysuckle stem have the effects of clearing heat and detoxicating, dispelling wind and dredging collaterals, and the borneol has the effects of clearing heat and relieving pain, and the licorice root has the effects of clearing heat and detoxicating and harmonizing the medicines, so that the medulla Tetrapanacis and the honeysuckle stem are used as an adjuvant. The whole formula has the effects of nourishing yin, clearing heat, detoxifying and relieving pain.
Drawings
FIG. 1 is a diagram of the feet of a patient suffering from hand-foot syndrome caused by a multi-target tyrosine kinase inhibitor antitumor drug provided by the invention;
FIG. 2 is a diagram of hands of a patient suffering from hand-foot syndrome caused by the multi-target tyrosine kinase inhibitor antitumor drug provided by the invention;
FIG. 3 is a foot diagram of example 4 of the present invention after treatment;
fig. 4 is a diagram of the hands after treatment according to example 4 of the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention more clear, the technical solutions of the embodiments of the present invention will be clearly and completely described below. The specific conditions are not noted in the examples and are carried out according to conventional conditions or conditions recommended by the manufacturer. The reagents or apparatus used were conventional products commercially available without the manufacturer's attention. In addition, the meaning of "and/or" as it appears throughout includes three parallel schemes, for example "A and/or B", including the A scheme, or the B scheme, or the scheme where A and B are satisfied simultaneously. In addition, the technical solutions of the embodiments may be combined with each other, but it is necessary to base that the technical solutions can be realized by those skilled in the art, and when the technical solutions are contradictory or cannot be realized, the combination of the technical solutions should be regarded as not exist and not within the protection scope of the present invention. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
The multi-receptor tyrosine kinase inhibitor has dual anti-tumor effect, and can directly inhibit tumor growth on one hand; on the other hand, the preparation can indirectly inhibit the growth of tumor cells by blocking the formation of tumor neovascularization, and is the most common clinical treatment method for tumors at present, and common drugs are as follows: sorafenib, an Luoti, lenvatinib, apatinib, regorafenib, sunitinib, furquitinib, pazopanib, acitinib and the like, and the multi-receptor tyrosine kinase inhibitor can act on a plurality of targets, has high efficiency, good safety and remarkable tumor inhibition effect, and becomes one of important means for tumor treatment. Hand-foot syndrome is one of the common toxic and side effects of multiple receptor tyrosine kinase inhibitors for treating tumors in recent years, for example, the incidence rate of hand-foot syndrome caused by sorafenib can be up to 40%, and the incidence rate of sunitinib can be up to 20%. Studies have shown that symptoms often occur in the first two cycles after administration, patients often fail to walk due to severe pain, even lose life self-care ability, and thus affect the treatment as desired, in sufficient amounts, and fail to achieve the intended therapeutic purpose. Therefore, finding a treatment method which has reliable curative effect, small side effect and economy for preventing and treating the toxic and side effect has very important clinical significance.
In view of the above, the invention provides a traditional Chinese medicine composition, application, gel and a preparation method of the gel, which have good effects of treating hand-foot syndrome caused by multi-target tyrosine kinase inhibitor antitumor drugs.
The technical scheme of the invention comprises the following raw materials in parts by weight: 10-20 parts of honeysuckle;
7-10 parts of radix scrophulariae; 4-8 parts of Chinese angelica; 4-8 parts of medulla Tetrapanacis; 4-8 parts of honeysuckle stem; 1-3 parts of liquorice; and 1-2 parts of borneol.
In the formula, honeysuckle: is dried flower bud or flower with initial opening of Lonicera japonica thunb Lonicera japonica, lonicera rubra Lonicera hypoglauca Miq, lonicera confusa DC, or Lonicera macranthoides Lonicera dasystyla red. Sweet in taste and cold in nature; enters lung and stomach channels, has the effects of clearing heat and detoxicating, cooling and dispelling wind heat; it is mainly used for treating carbuncle, furuncle, pharyngitis, erysipelas, dysentery due to heat and blood, wind-heat type common cold, and fever due to warm diseases.
Radix scrophulariae: is dried root of radix scrophulariae Scrophularia ningpoensis hemsl of Scrophulariaceae. Bitter, salty and slightly cold. Enter the lung and kidney meridians. Has effects of nourishing yin, lowering fire, cooling blood, and removing toxic substances; it is often used for fever, fluid consumption, polydipsia, macula, constipation due to intestinal dryness, yin deficiency, bone steaming, fatigue and fever, insomnia, spontaneous perspiration, night sweat, hematemesis, and epistaxis.
Chinese angelica root: is the dry root of Angelica sinensis Angelica sinensis (Oliv.) Diels of Umbelliferae. Sweet and pungent in flavor and warm in nature. Enters the heart, liver and spleen meridians. Has effects of replenishing blood, promoting blood circulation, regulating menstruation, relieving pain, moistening dryness, and relieving intestinal stasis, and can be used for treating abdominal mass, rheumatalgia, lumbar muscle strain, carbuncle, skin ulcer, and traumatic injury.
Medulla Tetrapanacis: dried stem pith of k.koch, general wood Tetrapanax papyriferus (hook.) of the araliaceae family. Sweet and light in taste, cold in nature; enter the lung, stomach and bladder channels; has effects of clearing heat and promoting diuresis, and promoting lactation, and can be used for treating dysuria, edema, urinary tract infection, and galactostasis.
Caulis Lonicerae: is dried stem and branch of lonicera japonica of Caprifoliaceae Lonicera japonica thunderb. Sweet and cold in taste. Enter lung and stomach meridians. Has effects of clearing heat and detoxicating, dispelling pathogenic wind and dredging collaterals. Can be used for treating epidemic febrile disease, dysentery, carbuncle, suppurative sore, rheumatic arthralgia, and joint red swelling and pain.
Licorice root: is dry root and rhizome of Glycyrrhiza uralensis Glycyrrhiza uralensis Fisch. Glycyrrhiza uralensis Glycyrrhiza inflata bat. Or Glycyrrhiza glabra Glycyrrhiza glabra L. Of Leguminosae. Sweet and flat. It enters heart, lung, spleen and stomach meridians. Has the effects of invigorating spleen, replenishing qi, clearing heat, detoxicating, eliminating phlegm, relieving cough, relieving spasm, relieving pain and harmonizing various medicines. Can be used for treating weakness of spleen and stomach, listlessness, debilitation, palpitation, short breath, cough with excessive phlegm, abdominal pain, limb spasm, carbuncle, swelling, sore and toxic materials, and relieving drug toxicity and intensity.
Borneol: is a crystal obtained by extracting resin and volatile oil processed product of borneol Dipterocarpus turbinatus Gaertn. F. Pungent, bitter and slightly cold in flavor. It enters heart, spleen and lung meridians. Has effects of inducing resuscitation, refreshing mind, clearing heat and relieving pain. Can be used for treating fever, unconsciousness, convulsion, apoplexy, phlegm syncope, qi stagnation syncope, middle-jiao coma, chest pain, conjunctival congestion, aphtha, laryngopharynx swelling and pain, and ear canal purulence.
According to clinical manifestations of hand and foot syndromes caused by multi-target tyrosine kinase inhibitors and the theory of cold and heat of traditional Chinese medicine, the multi-target tyrosine kinase inhibitors are considered to belong to the nature of fire heat and the fire heat, are easy to cause carbuncle and ulcer, drug toxin flows into meridians, are accumulated in hands and feet, fire toxin internal depression, qi movement disorder, blood stasis and stagnation, and meanwhile, pathogenic fire heat consumes qi to hurt body fluid, so that symptoms such as skin erythema, ulcers, swelling and pain, desquamation, chapping, induration-like blisters and the like at the tail ends of limbs appear, and belong to the category of 'carbuncle' and 'sore and ulcer' in traditional Chinese medicine, and the following formula: for treating gangrene, it is indicated for yin-nourishing, heat-clearing, blood-activating and pain-relieving. On the basis, the traditional Chinese medicine composition is proposed: is prepared from flos Lonicerae, radix scrophulariae, radix Angelicae sinensis, medulla Tetrapanacis, caulis Lonicerae, glycyrrhrizae radix, and Borneolum Syntheticum. Honeysuckle flower, flos Lonicerae, sweet in flavor and cold in nature, is good at clearing heat and removing toxicity to treat carbuncle and cellulitis, and is a monarch drug. Radix scrophulariae, has effects of clearing heat and cooling blood, radix Angelicae sinensis, nourishing blood and yin to promote tissue regeneration, removing blood stasis and dredging collaterals to relieve pain, and is used as ministerial drug, the medulla Tetrapanacis and the honeysuckle stem have the effects of clearing heat and detoxicating, dispelling wind and dredging collaterals, and the borneol has the effects of clearing heat and relieving pain, and the licorice root has the effects of clearing heat and detoxicating and harmonizing the medicines, so that the medulla Tetrapanacis and the honeysuckle stem are used as an adjuvant. The whole formula has the effects of nourishing yin, clearing heat, detoxifying and relieving pain.
Further, the traditional Chinese medicine composition comprises the following raw materials of 10 parts by weight of honeysuckle; 8 parts of radix scrophulariae; 5 parts of Chinese angelica; 5 parts of medulla Tetrapanacis; 5 parts of honeysuckle stem; 3 parts of liquorice; and 1 part of borneol, and under the formula, the effect of treating the hand-foot syndrome caused by the multi-target tyrosine kinase inhibitor antitumor drug is optimal.
Further, in order to facilitate the use of the Chinese medicinal composition, all the raw materials are mixed to obtain a mixed raw material; the mixed raw materials are soaked, boiled, filtered and concentrated to obtain pasty raw materials, the soaking and boiling time is determined according to the specific dosage in the preparation process, the soaking is for enabling the effective components in the medicine to permeate out, the boiling is convenient, and the prepared pasty medicine can be applied to an affected part, so that the use is convenient.
In some embodiments, the mixed raw materials can be soaked while ultrasound is performed to promote the exudation of the effective components, and the ultrasound time can be 10-30min.
In some embodiments, in order to facilitate the penetration of the active ingredients in the medicine, the weight ratio of the soaking solution to the mixed raw materials is 10-15:1 when the mixed raw materials are soaked, when the soaking solution is too little, the active ingredients in the medicine cannot be soaked out as much as possible, when the water is too much, the subsequent boiling process is inconvenient, water resources are wasted, and fuel is also wasted.
The invention also provides application of the traditional Chinese medicine composition in preparing medicines for treating hand-foot syndromes, and the traditional Chinese medicine composition has good effect of treating the hand-foot syndromes caused by multi-target tyrosine kinase inhibitor antitumor medicines.
The application includes all technical solutions of the pharmaceutical composition, so that all the beneficial effects brought by the above solutions are also provided, and are not described in detail herein.
The invention provides a gel, which comprises a matrix and the traditional Chinese medicine composition, wherein the traditional Chinese medicine composition is mixed with the matrix to prepare gel, and the gel is adhered to an affected part when in use, so that the gel is convenient to use.
The gel comprises all technical schemes of the pharmaceutical composition, so that the gel has all the beneficial effects brought by the schemes, and the description is omitted herein.
Further, the mass ratio of the matrix to the traditional Chinese medicine composition is 10-20:1, the matrix is used for carrying the traditional Chinese medicine composition and is used for preparing gel, and too little matrix can not carry and protect the traditional Chinese medicine composition, so that waste is generated due to too much matrix.
The matrix is a mild substance which cannot destroy the drug property of the traditional Chinese medicine composition, and preferably comprises the following raw materials in parts by weight: 1-5 parts of chitosan; 4-6 parts of glycerol; 1-2 parts of azone; 34-36 parts of ethanol; and 60-70 parts of water.
The invention provides a preparation method of a gel, which comprises the steps of firstly uniformly mixing water, chitosan, glycerol, azone and ethanol, and then adding the pasty traditional Chinese medicine composition to uniformly mix to obtain the gel. Simple preparation, strong pertinency and good effect of treating hand-foot syndrome caused by multi-receptor tyrosine kinase inhibitor.
The following technical solutions of the present invention will be described in further detail with reference to specific examples and drawings, and it should be understood that the following examples are only for explaining the present invention and are not intended to limit the present invention.
Example 1
A traditional Chinese medicine composition comprises the following raw materials in parts by weight: 10 parts of honeysuckle, 7 parts of radix scrophulariae, 4 parts of Chinese angelica, 4 parts of medulla Tetrapanacis, 4 parts of honeysuckle stem, 1 part of liquorice and 1 part of borneol.
Example 2
A traditional Chinese medicine composition comprises the following raw materials in parts by weight: 10 parts of honeysuckle, 8 parts of radix scrophulariae, 5 parts of Chinese angelica, 5 parts of medulla Tetrapanacis, 5 parts of honeysuckle stem, 3 parts of liquorice and 1 part of borneol.
Example 3
A traditional Chinese medicine composition comprises the following raw materials in parts by weight: 20 parts of honeysuckle, 10 parts of radix scrophulariae, 8 parts of Chinese angelica, 8 parts of medulla Tetrapanacis, 8 parts of honeysuckle stem, 3 parts of liquorice and 2 parts of borneol.
EXAMPLE 4,
A traditional Chinese medicine composition comprises the following raw materials in parts by weight: 10 parts of honeysuckle, 8 parts of radix scrophulariae, 5 parts of Chinese angelica, 5 parts of medulla Tetrapanacis, 5 parts of honeysuckle stem, 3 parts of liquorice and 1 part of borneol.
The preparation method of the gel comprises the following steps:
weighing the traditional Chinese medicine composition according to the formula, mixing and soaking according to the weight ratio of distilled water to the traditional Chinese medicine composition of 10:1, simultaneously carrying out ultrasonic treatment during soaking for 10-30min, decocting for 1h after soaking, filtering, discarding residues, filtering and concentrating to obtain a pasty raw material;
precisely weighing 1.5 parts of chitosan, 5 parts of glycerol, 1 part of azone, 35 parts of ethanol and 65 parts of water, adding glycerol into water, adding chitosan for full swelling, stirring uniformly, adding azone, stirring uniformly, adding the rest water, and stirring fully to obtain a matrix;
the weight ratio of the matrix to the paste raw materials is 20:1, adding the mixture into a vacuum stirrer, and fully stirring the mixture to obtain the gel.
Comparative example 1
Vitamin B6
Performance testing
(1) Sample of
60 patients are patients receiving the multi-receptor tyrosine kinase inhibitor for treating tumors in hospitals and are diagnosed with hand-foot syndrome through diagnosis, wherein the 60 patients are divided into A, B, C groups of 20 people, and each group comprises 10 men and 10 women;
(2) Diagnostic criteria
Hand-foot syndrome is classified into 4 grades according to World Health Organization (WHO) standard:
stage 1: dullness/abnormal sensation of hands and feet, tingling sensation; visible erythema, histologically visible vascular dilation of the epidermal reticulum;
2 stages: discomfort during holding or walking, no painful swelling or erythema, and red swelling;
3 stages: painful erythema and swelling of the palms and soles, perinail erythema and swelling, visible chapped skin, isolated necrotic keratinocytes in the histological epidermis:
4 stages: desquamation, ulcers, blisters, severe pain, visible blisters.
(3) Therapeutic method
Examples 1, 4 and comparative example 1 correspond to three groups A, B, C, respectively, and the traditional Chinese medicine composition in example 1 is also prepared into gel preparations, and the methods for using the gel preparations in examples 1 and 4 are as follows: the gel is uniformly applied on the affected part with the thickness of 2-3mm, 2 times daily, 1 time each in the morning and evening, and 2 weeks of observation, and the vitamin B6 in comparative example 1 is used according to the existing method.
(4) Standard of efficacy
The effect is shown: symptoms disappeared or were reduced by 2 grades;
the method is effective: symptom relief 1 grade;
invalidation: the symptoms are not obviously improved.
Total effective rate = significant rate + effective rate.
(5) Therapeutic effects
The effect was observed for two consecutive weeks, and the effect of example 1 was: 15 cases are obvious, 5 cases are effective, and the total effective rate is 100%; the effects of example 4 are: 17 cases are obvious, 3 cases are effective, and the total effective rate is 100%; the effect of comparative example 1 is: 10 cases of obvious effect, 5 cases of effective and 5 cases of ineffective, and the total effective rate is 75%.
Typical case
Li Mou female, 65 years old. Hand-foot reactions appeared after 5 days of sorafenib administration. The symptoms are as follows: painful erythema and swelling of the palms and soles, periungual erythema and swelling, visible chapped skin, isolated necrotic keratinocytes in the histological epidermis, and inability to walk due to pain in the hands and feet. Prescription: the gel of example 4 was applied to the affected area with a thickness of 2-3mm, and twice daily. Pain disappears after 2 days of gel application, and after 7 days, the patient walks normally for discharge, and the treatment effect is shown in figures 1-4.
The foregoing is merely a preferred embodiment of the present invention and is not intended to limit the scope of the present invention, but various modifications and variations will be apparent to those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention should be included in the scope of the present invention.

Claims (10)

1. The traditional Chinese medicine composition is characterized by comprising the following raw materials in parts by weight: 10-20 parts of honeysuckle;
7-10 parts of radix scrophulariae;
4-8 parts of Chinese angelica;
4-8 parts of medulla Tetrapanacis;
4-8 parts of honeysuckle stem;
1-3 parts of liquorice; the method comprises the steps of,
1-2 parts of borneol.
2. The traditional Chinese medicine composition according to claim 1, which comprises the following raw materials in parts by weight: 10 parts of honeysuckle;
8 parts of radix scrophulariae;
5 parts of Chinese angelica;
5 parts of medulla Tetrapanacis;
5 parts of honeysuckle stem;
3 parts of liquorice; the method comprises the steps of,
and 1 part of borneol.
3. The Chinese medicinal composition according to claim 1 or 2, wherein all of the raw materials are mixed to obtain a mixed raw material;
the mixed raw materials are soaked, decocted, filtered and concentrated to obtain pasty raw materials.
4. The Chinese medicinal composition according to claim 3, wherein the weight ratio of the soaking solution to the mixed raw materials is 10-15:1 when the mixed raw materials are soaked.
5. Use of a Chinese medicinal composition according to any one of claims 1-4 in the manufacture of a medicament for the treatment of hand-foot syndrome.
6. The use according to claim 5, wherein the hand-foot syndrome is hand-foot syndrome caused by a multi-target tyrosine kinase inhibitor antitumor drug.
7. A gel comprising a matrix and the Chinese medicinal composition of any one of claims 1-4.
8. The gel of claim 7, wherein the mass ratio of the matrix to the traditional Chinese medicine composition is 10-20:1.
9. the gel of claim 7, wherein the matrix comprises the following raw materials in parts by weight: 1-5 parts of chitosan;
4-6 parts of glycerol;
1-2 parts of azone;
34-36 parts of ethanol; the method comprises the steps of,
60-70 parts of water.
10. The method for preparing gel according to claim 9, wherein water, chitosan, glycerin, azone and ethanol are mixed uniformly, and then the paste-like Chinese medicinal composition is added to be mixed uniformly, so as to obtain the gel.
CN202310981091.0A 2023-08-03 2023-08-03 Traditional Chinese medicine composition, application, gel and preparation method of gel Pending CN116870072A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103656111A (en) * 2012-09-06 2014-03-26 唐贝宁医药科技（北京）有限公司 Internal traditional Chinese medicine preparation for preventing and treating diabetic foot and preparation method thereof
CN108261470A (en) * 2018-01-26 2018-07-10 浙江省中医院 A kind of peaceful prescription of brothers
CN113209238A (en) * 2021-06-29 2021-08-06 潘波 Lotion for treating hand-foot syndrome caused by targeted medicament and preparation method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103656111A (en) * 2012-09-06 2014-03-26 唐贝宁医药科技（北京）有限公司 Internal traditional Chinese medicine preparation for preventing and treating diabetic foot and preparation method thereof
CN108261470A (en) * 2018-01-26 2018-07-10 浙江省中医院 A kind of peaceful prescription of brothers
CN113209238A (en) * 2021-06-29 2021-08-06 潘波 Lotion for treating hand-foot syndrome caused by targeted medicament and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
刘恒禄: "四妙勇安汤治疗血栓闭塞性脉管炎58例临床观察", 中华养生保健, no. 18, 15 June 2005 (2005-06-15), pages 47 - 48 *

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