CN114748524B - Traditional Chinese medicine composition for removing black eye bags - Google Patents

Traditional Chinese medicine composition for removing black eye bags Download PDF

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CN114748524B
CN114748524B CN202210573783.7A CN202210573783A CN114748524B CN 114748524 B CN114748524 B CN 114748524B CN 202210573783 A CN202210573783 A CN 202210573783A CN 114748524 B CN114748524 B CN 114748524B
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chinese medicine
traditional chinese
parts
black eye
medicine composition
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CN114748524A (en
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朱化珍
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Shanghai Pudong New Area Pulmonary Hospital Shanghai Pudong New Area Second Red Cross Elderly Care Hospital
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Shanghai Pudong New Area Pulmonary Hospital Shanghai Pudong New Area Second Red Cross Elderly Care Hospital
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282—Artemisia, e.g. wormwood or sagebrush
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233—Bupleurum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287—Chrysanthemum, e.g. daisy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/005—Preparations for sensitive skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions
    • A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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Abstract

The invention provides a traditional Chinese medicine composition. The invention further provides a traditional Chinese medicine extract and a preparation method thereof. The invention further provides a traditional Chinese medicine preparation. The invention further provides a facial mask and a preparation method thereof. The invention particularly provides application of the traditional Chinese medicine composition, or the traditional Chinese medicine extract, or the traditional Chinese medicine preparation, or the mask in preparing medicines for removing the black eye bags. The traditional Chinese medicine composition for removing the black eye bags provided by the invention is used for removing the black eye bags, has the advantages of remarkable effect, high cure rate and no toxic or side effect, and is more easily accepted by patients.

Description

Traditional Chinese medicine composition for removing black eye bags
Technical Field
The invention belongs to the technical field of traditional Chinese medicine pharmacy, relates to a traditional Chinese medicine composition for removing black eye bags, and in particular relates to a traditional Chinese medicine composition for removing black eye bags, and preparation and application thereof.
Background
Clinically, people in middle and old age have bad rest, overfatigue and bad sleep, and the kidney is ill and tired to cause accumulation of eye body fluid to form a black eye pouch, so that symptoms of loose skin, aging and eye aging are presented. With the age, the appearance of the patient is seriously affected. The modern cosmetic surgery has poor treatment effect and is easy to cause complications such as infection; the methods of hot compress, physiotherapy, massage and the like can be temporarily alleviated, but the recurrence is easy.
The root cause of the occurrence of the black pouch is considered by the traditional Chinese medicine to be the deficiency of liver and kidney, qi movement disorder, phlegm retention internal stop, blood stasis and collateral obstruction. A large number of clinical studies have demonstrated that traditional Chinese medicine has a relatively significant advantage in the removal of symptoms of the black eye pouch. Therefore, active and effective therapeutic drugs are sought, and the improvement of the black eye bags is achieved to the greatest extent in a safer and more convenient way, and the method has great significance for improving the life quality of patients.
Disclosure of Invention
In view of the above-mentioned drawbacks of the prior art, the present invention aims to provide a traditional Chinese medicine composition for removing black eye bags, which has outstanding effect and high cure rate.
In order to achieve the above and other related objects, the first aspect of the present invention provides a traditional Chinese medicine composition for removing a black eye pouch, which comprises the following active ingredients in parts by weight:
1-15 parts of virgate wormwood herb;
1-15 parts of white chrysanthemum;
1-15 parts of eucommia ulmoides;
1-15 parts of teasel root;
1-10 parts of bupleurum.
The second aspect of the invention provides a traditional Chinese medicine extract, which is prepared by taking the traditional Chinese medicine composition of the first aspect of the invention as a raw material to extract effective components.
The third aspect of the present invention provides a method for preparing the above-mentioned Chinese herbal extract, comprising: the effective components of the traditional Chinese medicine composition of the first aspect of the invention are extracted after being mixed according to the proportion, so as to provide the traditional Chinese medicine extract.
In a fourth aspect, the present invention provides a Chinese medicinal preparation comprising a therapeutically effective amount of the Chinese medicinal composition according to the first aspect of the present invention, or a therapeutically effective amount of the Chinese medicinal extract according to the second aspect of the present invention, and one or more conventional pharmaceutically acceptable excipients.
The fifth aspect of the invention provides a preparation method of a facial mask for removing black eye bags, which comprises the steps of taking the medicinal components of the traditional Chinese medicine composition according to the first aspect of the invention according to a proportion, mixing, and adding a proper amount of warm water to prepare a paste so as to provide the facial mask.
The sixth aspect of the invention provides a facial mask for removing black pouch, which is prepared by the method.
The seventh aspect of the invention provides the use of the traditional Chinese medicine composition provided by the first aspect of the invention, or the traditional Chinese medicine extract provided by the second aspect of the invention, or the traditional Chinese medicine preparation provided by the fourth aspect of the invention, or the mask provided by the sixth aspect of the invention in the preparation of medicines for removing black eye bags.
As described above, the traditional Chinese medicine composition for removing the black eye bags provided by the invention has the advantages of reasonable compatibility of raw material medicines, definite action, no adverse reaction, no medicine dependence and simple preparation method. The traditional Chinese medicine in the traditional Chinese medicine composition is used as a medicine for removing the black eye bags, and has the advantages of remarkable effect, high conversion rate and high cure rate. The traditional Chinese medicine composition can be used as a facial mask, compared with oral medicines, the traditional Chinese medicine composition can directly act on local skin, is simple and convenient, has quick effect, is a pure traditional Chinese medicine preparation, has no toxic or side effect, and is more easily accepted by patients.
Drawings
Fig. 1 shows a photograph of the pouch condition of case 1 patient before treatment in example 9 of the present invention.
Fig. 2 shows a photograph of the pouch condition of case 1 patient after treatment in example 9 of the present invention.
Fig. 3 shows a photograph of the pouch condition of case 2 patient before treatment in example 9 of the present invention.
Fig. 4 shows a photograph of the pouch condition of case 2 patient after treatment in example 9 of the present invention.
Fig. 5 shows a photograph of the condition of the eye bag of the patient before treatment in case 3 in example 9 of the present invention.
Fig. 6 shows a photograph of the pouch condition of case 3 patient after treatment in example 9 of the present invention.
Fig. 7 shows a photograph of the condition of the eye bag of case 4 patient before treatment in example 9 of the present invention.
Fig. 8 shows a photograph of the pouch condition of case 4 patient after treatment in example 9 of the present invention.
Fig. 9 shows a photograph of the condition of the eye bag of the patient before treatment in case 5 in example 9 of the present invention.
Fig. 10 shows a photograph of the pouch condition of case 5 patient after treatment in example 9 of the present invention.
Fig. 11 shows a photograph of the pouch condition of case 6 patient before treatment in example 9 of the present invention.
Fig. 12 is a photograph showing the condition of the eye bag of the patient after treatment in case 6 in example 9 of the present invention.
Fig. 13 shows a photograph of the pouch condition of case 7 patient before treatment in example 9 of the present invention.
Fig. 14 shows a photograph of the pouch condition of case 7 patient after treatment in example 9 of the present invention.
Detailed Description
Before the embodiments of the invention are explained in further detail, it is to be understood that the invention is not limited in its scope to the particular embodiments described below; it is also to be understood that the terminology used in the examples of the invention is for the purpose of describing particular embodiments only, and is not intended to limit the scope of the invention. The test methods in the following examples, in which specific conditions are not noted, are generally conducted under conventional conditions or under conditions recommended by the respective manufacturers.
Where numerical ranges are provided in the examples, it is understood that unless otherwise stated herein, both endpoints of each numerical range and any number between the two endpoints are significant both in the numerical range. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In addition to the specific methods, devices, materials used in the embodiments, any methods, devices, and materials of the prior art similar or equivalent to those described in the embodiments of the present invention may be used to practice the present invention according to the knowledge of one skilled in the art and the description of the present invention.
Unless otherwise indicated, the experimental methods, detection methods, and preparation methods disclosed in the present invention all employ techniques conventional in the art.
The invention provides a traditional Chinese medicine composition for removing black eye bags, which comprises the following medicinal components in parts by weight:
1-15 parts of virgate wormwood herb;
1-15 parts of white chrysanthemum;
1-15 parts of eucommia ulmoides;
1-15 parts of teasel root;
1-10 parts of bupleurum.
In the invention, the herba artemisiae scopariae (ARTEMISIAE SCOPARIAE HERBA) is a dry aerial part of the asteraceae plant artemisia scoparia Artemisia scoparia waldst. The herba Artemisiae Scopariae has effects of clearing heat and dampness, promoting bile flow, and eliminating jaundice.
In the invention, the white chrysanthemum (WHITE CHRYSANTHEMI FLOS) is a dried head-like inflorescence of chrysanthemum Chrysanthemum morifolium Ramat. The flos Chrysanthemi has effects of dispelling pathogenic wind, clearing heat, suppressing hyperactive liver, improving eyesight, and clearing heat and toxic materials.
In the present invention, eucommia ulmoides (eucommia ulmoides) is a dried bark of eucommia ulmoides Eucommia ulmoides Oliv. The cortex Eucommiae has effects of nourishing liver and kidney, strengthening tendons and bones, and preventing miscarriage.
In the invention, the Dipsacus root (Dipsaci RADIX) is a dry root of Dipsacus asperus asper wall. Ex Henry of Dipsacaceae. The radix Dipsaci has effects of nourishing liver and kidney, strengthening tendons and bones, relieving fracture, and stopping metrorrhagia. In the present invention, the Bupleurum (Bupleri RADIX) is the dried root of Bupleurum chinense DC or Bupleurum angustifolium Bupleurum scorzonerifolium Willd. The radix bupleuri has the effects of dispelling heat, soothing liver, relieving depression, and lifting yang qi.
The raw materials (or medicinal materials) adopted by the invention can be purchased from common medical shops or Chinese medicinal material selling companies, and the specification of the raw materials (or medicinal materials) accords with the national medical standard or the related regulations of Chinese pharmacopoeia and the like.
The traditional Chinese medicine composition for removing the black eye bags, which is compatible with the invention, fully follows the principle of dialectical treatment of traditional Chinese medicine, and is particularly invented for removing the black eye bags. The following Chinese medicines are mutually compatible, can exert the synergistic effect of the Chinese medicines, and the components of the raw materials of the Chinese medicines have the effects of interweaving, promoting and coordinating mutually. Specifically, the selected herba artemisiae scopariae and the white chrysanthemum enter liver channels to clear liver and remove dampness, the selected eucommia ulmoides and the teasel roots have the effects of tonifying liver and kidney and can assist the monarch drugs to remove dampness, and the selected radix bupleuri has the effects of soothing liver and lifting yang qi as assistant drugs. The above medicines are combined for use, and the effects of tonifying liver and kidney, promoting qi circulation, promoting diuresis and dredging collaterals can be achieved.
In a preferred embodiment of the present invention, the pharmaceutical composition comprises the following components in parts by weight:
5-9 parts of virgate wormwood herb;
6-15 parts of white chrysanthemum;
6-15 parts of eucommia ulmoides;
6-15 parts of teasel root;
3-9 parts of bupleurum.
In a further preferred embodiment of the present invention, the pharmaceutical composition comprises the following components in parts by weight:
6-9 parts by weight of virgate wormwood herb; specifically, 6-7 parts by weight, 7-8 parts by weight and 8-9 parts by weight;
9-15 parts of white chrysanthemum; specifically, 9-11 parts by weight, 11-13 parts by weight, and 13-15 parts by weight;
9-15 parts of eucommia ulmoides; specifically, 9-11 parts by weight, 11-13 parts by weight, and 13-15 parts by weight;
9-15 parts of teasel root; specifically, 9-11 parts by weight, 11-13 parts by weight, and 13-15 parts by weight;
6-9 parts of bupleurum; specifically, 6-7 parts by weight, 7-8 parts by weight and 8-9 parts by weight are mentioned.
The second aspect of the invention provides a traditional Chinese medicine extract, which is prepared by taking the traditional Chinese medicine composition of the first aspect of the invention as a raw material to extract effective components.
The third aspect of the present invention provides a method for preparing the above-mentioned Chinese herbal extract, comprising: the effective components of the traditional Chinese medicine composition of the first aspect of the invention are extracted after being mixed according to the proportion, so as to provide the traditional Chinese medicine extract.
In a preferred embodiment of the present invention, the medicinal components are pulverized and mixed according to a certain proportion.
In a further preferred embodiment of the invention, the comminution is by grinding. The components can be effectively mixed after being crushed into particles by adopting a grinding mode, so as to be beneficial to the extraction of the traditional Chinese medicine active ingredients of the traditional Chinese medicine composition.
In a further preferred embodiment of the present invention, the individual pharmaceutically effective ingredients are crushed to a particle size of 625-800 mesh (15-20 microns). The effective components in the traditional Chinese medicine composition are easier to obtain by adopting the traditional Chinese medicine powder particles with the particle size.
In the invention, each medicinal effect component in the traditional Chinese medicine composition formula is the most critical, and after knowing the traditional Chinese medicine composition formula, a person skilled in the art can adopt various conventional traditional Chinese medicine effective component extraction methods to extract the effective components, such as conventional decoction, water extraction and alcohol precipitation methods, alcohol extraction and water precipitation methods, salting-out methods and the like, and the extraction methods can obtain the main medicinal effect components in the traditional Chinese medicine composition formula, so that the traditional Chinese medicine composition formula has a certain curative effect on removing the black eye bags.
The water extraction and alcohol precipitation method comprises the following steps: extracting the effective components of the medicinal materials by using water as a solvent, and removing impurities in the extracting solution by using ethanol precipitation with different concentrations. Generally, when the ethanol content reaches 50-60% (weight/volume ratio, i.e. g/100 ml), impurities such as starch can be removed, and when the ethanol content reaches more than 75%, most of the impurities except for few ineffective components such as tannins, water-soluble pigments and the like can be removed by precipitation.
The alcohol extraction and water precipitation method comprises the following steps: extracting the medicinal material components with ethanol with proper concentration, and removing impurities in the extracting solution with water.
The traditional Chinese medicine composition can be concentrated, purified or dried by conventional steps after extracting the effective components to obtain the traditional Chinese medicine extract. Methods of concentration include, but are not limited to: atmospheric pressure evaporation, reduced pressure evaporation, thin film evaporation and multiple effect evaporation; methods of purification include, but are not limited to: salting out purification, macroporous resin adsorption purification, ethanol precipitation purification, ion exchange resin purification, flocculation precipitation purification, membrane separation purification, polyamide adsorption purification, silica gel adsorption chromatography purification and the like; methods of drying include, but are not limited to: drying, drum drying, belt drying, moisture absorption drying, boiling drying, spray drying, reduced pressure drying, freeze drying, infrared drying, microwave drying, etc.
According to the characteristics of the effective components of different crude drugs in the traditional Chinese medicine composition, different extraction processes can be adopted.
In a fourth aspect, the present invention provides a Chinese medicinal preparation comprising a therapeutically effective amount of the Chinese medicinal composition according to the first aspect of the present invention, or a therapeutically effective amount of the Chinese medicinal extract according to the second aspect of the present invention, and one or more conventional pharmaceutically acceptable excipients.
Pharmaceutically acceptable excipients include (but are not limited to): pharmaceutically acceptable carriers, diluents, fillers, binders, disintegrants, lubricants, suspending agents, binders, sweeteners, flavoring agents, preservatives and other excipients. Therapeutically inert inorganic or organic carriers known to those skilled in the art include, but are not limited to, lactose, corn starch or derivatives thereof, talc, vegetable oils, waxes, fats, poly-antelope based compounds such as polyethylene glycols, water, sucrose, ethanol, glycerol and the like, various preservatives, lubricants, dispersants, flavoring agents. Humectants, antioxidants, sweeteners, colorants, stabilizers, salts, buffers and the like may also be added thereto as needed to aid stability of the formulation or to aid in enhancing activity or its bioavailability.
Traditional Chinese medicine preparations such as granules and ointments can be prepared by conventional methods. The pharmaceutical compositions of the present invention may also be used with other therapeutic agents.
After extracting the effective components in the traditional Chinese medicine composition, the traditional Chinese medicine composition can be prepared by adopting conventional pharmaceutical auxiliary materials and additives.
The effective therapeutic dose of the pharmaceutical composition of the invention is based on the total weight of the raw materials, and the specific dose also considers the factors such as the administration route, the health condition of the patient and the like, which are all within the skill of the skilled doctor.
The fifth aspect of the invention provides a preparation method of a facial mask for removing black eye bags, which comprises the steps of taking the medicinal components of the traditional Chinese medicine composition according to the first aspect of the invention according to a proportion, mixing, and adding a proper amount of warm water to prepare a paste so as to provide the facial mask.
The facial mask can be applied to the dark under-eye bags or dark under-eye circles of patients in small amount.
In a preferred embodiment of the present invention, the medicinal components are pulverized and mixed according to a certain proportion.
In a further preferred embodiment of the invention, the comminution is by grinding. The grinding mode can uniformly mix the components so as to be beneficial to the effect of the medicinal components in the mask.
In a further preferred embodiment of the present invention, the individual pharmaceutically effective ingredients are crushed to a particle size of 625-800 mesh (15-20 microns). The traditional Chinese medicine powder particles with the particle size can more easily act on each medicinal component in the facial mask.
The proper amount of warm water is added according to the dosage of each medicinal component of the traditional Chinese medicine composition, so that the traditional Chinese medicine composition is pasty.
In a preferred embodiment of the present invention, the mass ratio of the Chinese medicinal composition to the water is 1:2-4, preferably 1:3.
In a preferred embodiment of the present invention, the temperature of the warm water is controlled to 25-35 ℃.
The paste is thin paste, and the degree of gelatinization is suitable for dipping with a foundation brush and then coating on the face without flowing.
In a preferred embodiment of the present invention, an appropriate amount of auxiliary materials may be added to the paste.
The auxiliary materials are pharmaceutically acceptable auxiliary materials. Specifically, the auxiliary material is honey. Can increase the viscosity of the facial mask.
The sixth aspect of the invention provides a facial mask for removing black pouch, which is prepared by the method.
The seventh aspect of the invention provides the use of the traditional Chinese medicine composition provided by the first aspect of the invention, or the traditional Chinese medicine extract provided by the second aspect of the invention, or the traditional Chinese medicine preparation provided by the fourth aspect of the invention, or the mask provided by the sixth aspect of the invention in the preparation of medicines for removing black eye bags.
The invention is further illustrated below in connection with specific examples, which are to be understood as being illustrative of the invention and not limiting the scope of the invention.
Other advantages and effects of the present invention will become apparent to those skilled in the art from the following disclosure, which describes the embodiments of the present invention with reference to specific examples. The invention may be practiced or carried out in other embodiments that depart from the specific details, and the details of the present description may be modified or varied from the spirit and scope of the present invention.
Example 1
The traditional Chinese medicine composition for removing the black eye bags comprises the following medicinal components in parts by weight: 9 parts of virgate wormwood herb, 15 parts of white chrysanthemum, 15 parts of eucommia ulmoides, 15 parts of teasel root and 9 parts of radix bupleuri. Grinding the above medicinal components into 625-800 mesh fine powder, and mixing at the above ratio to obtain Chinese medicinal extract sample 1.
Example 2
The traditional Chinese medicine composition for removing the black eye bags comprises the following medicinal components in parts by weight: 9 parts of virgate wormwood herb, 15 parts of white chrysanthemum, 12 parts of eucommia ulmoides, 12 parts of teasel root and 9 parts of radix bupleuri. Grinding the above medicinal components into 625-800 mesh fine powder, and mixing at the above ratio to obtain Chinese medicinal extract sample 2.
Example 3
The traditional Chinese medicine composition for removing the black eye bags comprises the following medicinal components in parts by weight: 9 parts of virgate wormwood herb, 15 parts of white chrysanthemum, 15 parts of eucommia ulmoides, 15 parts of teasel root and 9 parts of radix bupleuri. Grinding the above medicinal components into 625-800 mesh fine powder, mixing, adding warm water, and concocting into paste to obtain facial mask sample No. 1.
Example 4
The traditional Chinese medicine composition for removing the black eye bags comprises the following medicinal components in parts by weight: 9 parts of virgate wormwood herb, 15 parts of white chrysanthemum, 12 parts of eucommia ulmoides, 12 parts of teasel root and 9 parts of radix bupleuri. Grinding the above medicinal components into 625-800 mesh fine powder, mixing, adding warm water, and concocting into paste to obtain facial mask sample No. 2.
Example 5
The traditional Chinese medicine composition for removing the black eye bags comprises the following medicinal components in parts by weight: 9 parts of virgate wormwood herb, 12 parts of white chrysanthemum, 15 parts of eucommia ulmoides, 15 parts of teasel root and 9 parts of radix bupleuri. Grinding the above medicinal components into 625-800 mesh fine powder, mixing, adding warm water, and concocting into paste to obtain facial mask sample No. 3.
Example 6
The traditional Chinese medicine composition for removing the black eye bags comprises the following medicinal components in parts by weight: 9 parts of virgate wormwood herb, 9 parts of white chrysanthemum, 9 parts of eucommia ulmoides, 9 parts of teasel root and 9 parts of radix bupleuri. Grinding the above medicinal components into 625-800 mesh fine powder, mixing, adding warm water, and concocting into paste to obtain facial mask sample No. 4.
Example 7
The traditional Chinese medicine composition for removing the black eye bags comprises the following medicinal components in parts by weight: 6 parts of virgate wormwood herb, 15 parts of white chrysanthemum, 12 parts of eucommia ulmoides, 12 parts of teasel root and 9 parts of radix bupleuri. Grinding the above medicinal components into 625-800 mesh fine powder, mixing, adding warm water, and concocting into paste to obtain facial mask sample No. 5.
Example 8
In order to verify the effect of removing the black eye bags in the present invention, the present invention developed the following clinical experiments.
1. Patient selection
Patients were selected for clinical trials, with 90 patients with black eye bags, age range: 30-65 years old, 30 men and 60 women.
2. Diagnostic criteria
Blackening, purple, reddish and bluish under the eyes and in the eye bags, which are different from normal complexion or swelling in the eye bags.
3. Therapeutic method
90 patients were randomized into 5 groups.
Wherein, group 1: the mask sample # 1 prepared in example 3 was applied to 20 patients, 10 men and 10 women, once daily, with a treatment course of 3 months.
Group 2: the mask sample # 2 prepared in example 4 was applied to 20 patients, 10 men and 10 women, once daily, with a treatment course of 3 months.
Group 3: the mask sample 3# prepared in example 5 was applied to 20 patients, 10 men and 10 women, once daily, with a treatment course of 3 months.
Group 4: patient 15, male 0, female 15, patient was given the same amount of mask sample # 4 prepared in example 6, applied to the patient's dark under eye pouch once daily for 3 months as a treatment course.
Group 5: patient 15, male 0, female 15, patient was given the same amount of mask sample # 5 prepared in example 7, applied to the pouch of the patient once daily for 3 months as a treatment course.
Curative effect judgment criteria:
and (3) healing: symptoms of the black eye bag disappear, and the patients with no recurrence over 1 week are clinically cured.
The method is effective: a reduction in symptoms of a pouch selected from any one or more of the following effective characteristics:
a) The eyelid edema area is reduced by more than or equal to 15 percent;
b) The area of the black halo is reduced by more than or equal to 15 percent;
c) The skin at the black halo part has light color.
The method for measuring the skin color of the black halo part comprises the following steps: skin melanin and heme content was measured using a skin melanin and heme tester (Mexameter MX18, manufactured by CK company, germany). Wherein the melanin level is characterized by an MI value and the heme content by an EI value, the lower the measurement value, the lower the melanin and heme content, i.e. the whiter the skin. In the present invention, a 20% decrease in MI or EI is considered effective, i.e., as a lightening of the skin at the site of the blush.
Invalidation: the symptoms of the pouch were not significantly changed.
4. Statistics of treatment outcome
(1) Effective rate of
Effective rate= (healer + effective person)/total person. As can be seen from Table 1, the total effective rate of 90 patients after treatment is up to 97.8%. The group 1 patients are all effective after treatment, and the effective rate is 100%; the effective rate of the group 2 patients after treatment is 95%; the effective rate of the patients in the group 3 after treatment is 95%; the group 4 patients are all effective after treatment, and the effective rate is 100%; the group 5 patients are all effective after treatment, and the effective rate is 100%.
Table 1 statistics of the effective rates of the groups
Headcount of people Group 1 Group 2 Group 3 Group 4 Group 5
Total number of cases 90 20 20 20 15 15
Male (example) 30 10 10 10 0 0
Female (example) 60 10 10 10 15 15
Healing (example) 38 8 9 8 7 6
Effective (example) 50 12 10 11 8 9
Invalidation (example) 2 0 1 1 0 0
Effective rate (%) 97.8 100 95 95 100 100
(2) Classification statistics of improvement of symptoms
After 90 patients were treated, the symptoms of most patients were improved, and the specific conditions are shown in Table 2.
Table 2 classification statistics for symptom improvement for each group
Number of people (example) Total effective number of people (examples) Group 1 Group 2 Group 3 Group 4 Group 5
Effective cure of the total number of people (examples) 88 15 20 19 19 15
Edema area reduction number of people (examples) 70 14 15 15 15 11
Black halo area reduces the number of people (examples) 80 13 18 17 18 14
The number of people with a lightening black halo 83 14 19 18 17 15
Note that: reduced edema area, reduced bluish color, etc., combined or independent appearance
(3) Melanin and heme measurement statistics
Skin melanin and heme content was measured using a skin melanin and heme tester (Mexameter MX18, manufactured by CK company, germany). Wherein the melanin level is characterized by MI value, and the heme content is characterized by EI value, and the specific situation is shown in Table 3. As can be seen from Table 3, the skin tone of the blackspot area became light in most patients after treatment of 90 patients.
TABLE 3 determination of skin pigment in black eye bags
Headcount (example) Group 1 Group 2 Group 3 Group 4 Group 5
The number of people with a lighten black pouch 83 19 18 17 15 14
MI value was reduced by 20% for the number of people (example) 73 18 15 15 12 13
EI value was reduced by 20% for the number of people (example) 60 15 15 12 10 8
EXAMPLE 9 typical case
Case 1: the patient is Zhengqi, female, shanghai, pudong, new region of the city, 33 years old. The patients have symptoms of dark under the eyes due to lochia after small childhood, soreness of waist and back, debilitation and discomfort after long time, and the condition of the eyes of the patients before treatment is shown in figure 1. As can be seen from fig. 1, the patient had bilateral lower eyelid ptosis edema with a dark color prior to treatment. The facial mask prepared by the traditional Chinese medicine in the embodiment 4 of the invention is used for treatment in 2021, the symptoms are obviously improved after the administration for 3 weeks, and the eye bag condition of a patient after the treatment is shown in fig. 2. As can be seen from fig. 2, the edema of the eyelids on both sides of the patient after treatment was significantly alleviated, and the color was light.
Case 2: the patient is about to be a woman, a new region of Pudong, shanghai, and aged 40. The patient has symptoms of facial edema, and clear black pouch due to emotional depression and insomnia, and the pouch condition of the patient before treatment is shown in figure 3. As can be seen in fig. 3, the bilateral eyelids of the pre-treatment patient are blue-black. The symptoms are obviously improved after 4 weeks of administration of the traditional Chinese medicine extract in the embodiment 1 of the invention after 2021, and the pouch condition of the patient after treatment is shown in fig. 4. As can be seen from fig. 4, the periocular pigmentation area of the patient was significantly reduced after treatment and the color changed to light cyan.
Case 3: shang Mou for a patient, male, 45 years old, in Pudong, shanghai, the dark circles were apparent when the patient was treated, the lower eyelid was edema, and the pouch was purple black, as shown in FIG. 5. The symptoms are obviously improved after 2 weeks of administration of the traditional Chinese medicine extract in the embodiment 2 of the invention after 2021, and the condition of the eye bags of the patients after treatment is shown in fig. 6.
Case 4: the patient is about to be somehow female, 54 years old. In the Pudong new region of Shanghai, the patient has feverish sensation in the chest, black and swollen lower eyelid, soreness and weakness of waist and knees, and the pouch condition of the patient before treatment is shown in fig. 7. The symptoms were significantly improved after 1 month of administration of the mask of example 3 of the present invention since 2021, and the pouch condition of the patient after treatment was shown in fig. 8.
Case 5: the patient is aged somewhere, women, 44 years old. The eye bag condition of the patient before treatment is shown in fig. 9, which is a new region of Pudong in Shanghai, because of the intense tension work, the irritability, eyelid swelling and slight blushing. The symptoms were significantly improved after 2 weeks of treatment with the mask of example 4 of the present invention, 2021, and the pouch condition of the patient after treatment was shown in fig. 10.
Case 6: patient Fan Mou, male, 49 years old. The eye bags of patients in the Pudong new region of Shanghai, with symptoms of irritability, soreness of waist and knees, insomnia, and dark green and black eye bags are shown in fig. 11. The symptoms were significantly improved after 1 month of administration of the mask of example 5 of the present invention since 2021, and the pouch condition of the patient after treatment was shown in fig. 12.
Case 7: patient Yang Mou, male, 31 years old. The pouch condition of the patient before treatment in the new region of Pudong, shanghai, the skin of the patient is dark, the pouch is obvious, the patient is depressed, and the patient is alert and uneasy, as shown in fig. 13. The symptoms were significantly improved after 2 weeks of treatment with the mask of example 3 of the present invention, 2021, and the pouch condition of the treated patient was shown in fig. 14.
While the invention has been described with respect to preferred embodiments thereof, it will be understood by those skilled in the art that various modifications and additions may be made without departing from the scope of the invention. Equivalent embodiments of the present invention will be apparent to those skilled in the art having the benefit of the teachings disclosed herein, when considered in the light of the foregoing disclosure, and without departing from the spirit and scope of the invention; meanwhile, any equivalent changes, modifications and evolution of the above embodiments according to the essential technology of the present invention still fall within the scope of the technical solution of the present invention.

Claims (11)

1. The external traditional Chinese medicine composition for removing the black eye bags comprises the following medicinal components in parts by weight:
1-15 parts of virgate wormwood herb;
1-15 parts of white chrysanthemum;
1-15 parts of eucommia ulmoides;
1-15 parts of teasel root;
1-10 parts of bupleurum.
2. The external traditional Chinese medicine composition for removing the black eye bags according to claim 1, which is characterized by comprising the following medicinal components in parts by weight:
5-9 parts of virgate wormwood herb;
6-15 parts of white chrysanthemum;
6-15 parts of eucommia ulmoides;
6-15 parts of teasel root;
3-9 parts of bupleurum.
3. A topical Chinese medicinal extract for removing black pouch is prepared by extracting effective components from the topical Chinese medicinal composition for removing black pouch as claimed in any one of claims 1-2.
4. The method for preparing a topical Chinese medicinal extract for removing black eye bags according to claim 3, comprising: mixing the medicinal components of the external traditional Chinese medicine composition for removing the black eye bags according to the proportion, and extracting the effective components.
5. The method for preparing a traditional Chinese medicine extract for external use for removing black eye bags according to claim 4, wherein the medicinal components are respectively crushed and then mixed according to a proportion.
6. The method for preparing a topical Chinese medicinal extract for removing black eye bags according to claim 5, wherein the medicinal components are pulverized to a particle size of 625-800 mesh.
7. A traditional Chinese medicine preparation for external use for removing black eye bags, which is prepared from a therapeutically effective amount of the traditional Chinese medicine composition for external use for removing black eye bags according to any one of claims 1-2 or a therapeutically effective amount of the traditional Chinese medicine extract for external use for removing black eye bags according to claim 3, and one or more conventional pharmaceutically acceptable auxiliary materials.
8. A preparation method of a facial mask for removing black eye bags, which comprises the steps of taking the medicinal components of the external traditional Chinese medicine composition for removing black eye bags according to any one of claims 1-2 according to a proportion, mixing, and adding a proper amount of warm water to prepare paste.
9. The method of preparing a facial mask for removing a black pouch according to claim 8, comprising any one or more of the following conditions:
1) The medicinal components are crushed respectively and then mixed according to a proportion, wherein the medicinal components are crushed to a particle size of 625-800 meshes;
2) The mass ratio of the traditional Chinese medicine composition to the water is 1:2-4;
3) The temperature of the warm water is controlled between 25 and 35 ℃.
10. A facial mask for removing dark under-eye puffiness, prepared by the method of any one of claims 8 to 9.
11. Use of the topical pouch-eliminating traditional Chinese medicine composition according to any one of claims 1-2, or the topical pouch-eliminating traditional Chinese medicine extract according to claim 3, or the topical pouch-eliminating traditional Chinese medicine preparation according to claim 7, in the preparation of a medicament for eliminating pouch.
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