CN106109932B - Whitening and freckle-removing traditional Chinese medicine composition, whitening and freckle-removing traditional Chinese medicine preparation, whitening and freckle-removing face cream and preparation method - Google Patents

Abstract

The invention relates to the technical field of traditional Chinese medicine skin care, in particular to a traditional Chinese medicine composition for whitening and removing freckles, a traditional Chinese medicine preparation for whitening and removing freckles, a cream for whitening and removing freckles and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw materials: 2-4 parts of radix curcumae extract, 2-4 parts of pseudo-ginseng extract, 3-5 parts of prepared rehmannia root extract, 5-7 parts of peach kernel extract, 2-4 parts of radix ophiopogonis extract, 2-4 parts of cyperus rotundus extract, 2-4 parts of radix bupleuri extract, 3-5 parts of bighead atractylodes rhizome extract, 2-4 parts of fructus forsythiae extract, 3-5 parts of bletilla striata root extract, 2-4 parts of salvia miltiorrhiza extract, 5-7 parts of radix paeoniae rubra extract, 3-5 parts of radix sileris extract, 2-4 parts of poria cocos extract, 2-4 parts of safflower extract, 2.5-5.5 parts of licorice root extract and 2-4 parts of angelica sinensis extract. The Chinese medicinal composition has the effects of promoting blood circulation, removing blood stasis, dredging channels and collaterals, supporting spleen, tonifying deficiency, regulating endocrine, and safely and long-acting, and can solve the problems of difficulty in fading and easy recurrence of facial speckle such as chloasma.

Description

Whitening and freckle-removing traditional Chinese medicine composition, whitening and freckle-removing traditional Chinese medicine preparation, whitening and freckle-removing face cream and preparation method

Technical Field

The invention relates to the technical field of traditional Chinese medicine skin care, in particular to a traditional Chinese medicine composition for whitening and removing freckles, a traditional Chinese medicine preparation for whitening and removing freckles, a cream for whitening and removing freckles and a preparation method thereof.

Background

Chloasma, also known as liver spots and butterfly spots, is a light brown or yellowish brown spot with clear border and irregular shape, is symmetrically distributed near the eye sockets, in the forehead, the eyebrow arch, the nose, the cheeks, the lips, the periphery of the mouth and the like without subjective symptoms and general discomfort, belongs to a symptom of facial melanosis, and is pigmentation spots occurring on the face. Endocrine dyscrasia, genetic factors, ultraviolet radiation, improper cosmetic application, special physiological period of women, mental stress and other factors obviously reduce the oxidation resistance of the skin of a human body, precipitate melanin, turn the skin dark yellow and rough, lack vital organs and further generate chloasma, thereby seriously affecting the external image. At present, most of spot removing products in the market lighten the color of spots from the surface layer of the skin by adding and using a mode of inhibiting neuraminidase or promoting stratum corneum metabolism, only can achieve the effect of lightening the spots on the surface layer, form spot removing false images and are easy to relapse. In addition, the addition of the used tyrosinase inhibitor and the stratum corneum metabolism product has the side effect of sensitizing the skin, and can be decomposed and oxidized when being irradiated by ultraviolet rays after being used, so that the deposition of melanin on the surface of the skin can be accelerated, and even the color of spots can be deepened. Therefore, research and development of natural freckle-removing products with good safety, stability, obvious inhibiting effect and good cost performance has become one of the main research directions of the current pharmaceutical and cosmetic industries.

Because of natural no side effect, the traditional Chinese medicine can achieve double effects of skin treatment and skin care when being applied to cosmetics and medicines, and is gradually pursued by people. The traditional Chinese medicine considers that the etiological mechanism of spot formation such as chloasma is attributed to deficiency and stasis, and is closely related to the dysfunction of the liver, spleen and kidney, the traditional Chinese medicine distinguishes that the dysfunction of the liver, spleen and kidney is caused, and deficiency of qi and blood and stasis are basic pathological changes. Stagnation of liver qi, qi stagnation leading to blood stasis; kidney deficiency with dryness, blood heat stagnation and blood stasis; spleen deficiency, qi deficiency, blood deficiency and failure of the driving can also cause stasis; finally, qi and blood can not nourish the face, and the pigment is deposited to form chloasma. Under the guidance of the above-mentioned theory of diagnosis and treatment of chloasma in traditional Chinese medicine, people also gradually research and develop a traditional Chinese medicine composition to achieve the effect of treating chloasma, for example, chinese patent CN105708979A discloses a traditional Chinese medicine composition for removing chloasma, which is composed of ligusticum chuanxiong hort, bletilla striata, salvia miltiorrhiza, white chrysanthemum, angelica, frankincense and medlar. In order to further meet the requirements of people on natural efficient freckle removing products, intensive and innovative research on freckle removing products of natural traditional Chinese medicine components becomes a problem to be solved at present.

Disclosure of Invention

In order to overcome the defects of the prior art, the invention aims to provide the traditional Chinese medicine composition for whitening and removing freckles, which has an obvious and efficient treatment effect on facial skin spots such as chloasma and the like and has the effect of whitening the skin.

The invention also aims to provide a whitening and freckle-removing traditional Chinese medicine preparation.

The invention also aims to provide the whitening and freckle-removing face cream.

The fourth purpose of the invention is to provide a preparation method of the whitening and freckle-removing face cream.

In order to achieve the above purpose, the technical scheme adopted by the invention is as follows:

a traditional Chinese medicine composition for whitening and removing freckles is composed of the following raw materials in parts by weight: 2-4 parts of radix curcumae extract, 2-4 parts of pseudo-ginseng extract, 3-5 parts of prepared rehmannia root extract, 5-7 parts of peach kernel extract, 2-4 parts of radix ophiopogonis extract, 2-4 parts of cyperus rotundus extract, 2-4 parts of radix bupleuri extract, 3-5 parts of bighead atractylodes rhizome extract, 2-4 parts of fructus forsythiae extract, 3-5 parts of bletilla striata root extract, 2-4 parts of salvia miltiorrhiza extract, 5-7 parts of radix paeoniae rubra extract, 3-5 parts of radix sileris extract, 2-4 parts of poria cocos extract, 2-4 parts of safflower extract, 2.5-5.5 parts of licorice root extract and 2-4 parts of angelica sinensis extract.

Preferably, the whitening and freckle-removing traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 3 parts of curcuma aromatica extract, 3 parts of pseudo-ginseng extract, 4 parts of prepared rehmannia root extract, 6 parts of peach kernel extract, 3 parts of dwarf lilyturf tuber extract, 3 parts of cyperus rotundus extract, 3 parts of bupleurum extract, 4 parts of bighead atractylodes rhizome extract, 3 parts of forsythia fruit extract, 4 parts of bletilla striata root extract, 3 parts of salvia miltiorrhiza extract, 6 parts of radix paeoniae rubra extract, 4 parts of radix sileris extract, 3 parts of poria cocos extract, 3 parts of safflower extract, 3.6 parts of licorice root extract and 3 parts of angelica sinensis extract.

A whitening and freckle-removing traditional Chinese medicine preparation comprises auxiliary materials required by preparation of the whitening and freckle-removing traditional Chinese medicine composition, a pharmaceutical preparation or a cosmetic preparation.

A whitening and freckle-removing facial cream comprises the whitening and freckle-removing traditional Chinese medicine composition and auxiliary materials required by preparation of the facial cream.

Optionally, the whitening and freckle-removing facial cream is prepared from the following raw materials in parts by weight: 60-63 parts of the traditional Chinese medicine composition for whitening and removing freckles, 20-25 parts of glycerin, 4-6 parts of carbomer, 1883.5-5.5 parts of poloxamer, 3-5 parts of propylene glycol, 0.5-1 part of sodium hydroxide, 0.5-1 part of imidazolidinyl urea, 70.2-0.4 part of cocoalcohol polyether, 0.05-0.2 part of PPG-1-PEG-9 lauryl glycol ether, 0.03-0.08 part of PEG-40 hydrogenated castor oil, 0.35-0.55 part of hyaluronic acid, 0.3-0.5 part of methyl hydroxybenzoate, 0.1-0.3 part of pearl powder, 0.1-0.2 part of 2-bromo-2-nitropropane-1, 3-diol, 0.1-0.2 part of disodium edetate, 0.1-0.3 part of rosa multiflora oil and 295-305 parts of water.

Preferably, the whitening and freckle-removing facial cream is prepared from the following raw materials in parts by weight: 61.6 parts of the traditional Chinese medicine composition for whitening and removing freckles, 22 parts of glycerin, 5.2 parts of carbomer, 1884.4 parts of poloxamer, 4 parts of propylene glycol, 0.832 part of sodium hydroxide, 0.8 part of imidazolidinyl urea, 70.3 parts of coco-alcohol polyether, 0.12 part of PPG-1-PEG-9 lauryl glycol ether, 0.06 part of PEG-40 hydrogenated castor oil, 0.44 part of sodium hyaluronate, 0.4 part of methyl hydroxybenzoate, 0.2 part of pearl powder, 0.16 part of 2-bromo-2-nitropropane-1, 3-diol, 0.16 part of disodium ethylenediamine tetraacetate, 0.2 part of rosa multiflora flower oil and 299.248 parts of water.

According to the whitening and freckle-removing facial cream, the whitening and freckle-removing traditional Chinese medicine composition is used as an effective component, and glycerin, propylene glycol and sodium hyaluronate are added and compounded to serve as the moisturizer, the moisturizers with three different molecular structures have synergistic effect, the use amount of a single moisturizer is reduced, and the moisturizing performance of the clear paste is improved, so that the moisturizing performance of the prepared clear paste is improved by 70% compared with that of a single-component moisturizer, the activity of the traditional Chinese medicine component is favorably maintained, the traditional Chinese medicine molecules can be continuously slowly released and permeate, and in the process that the moisturizer enters cells through pores, the effective components of the traditional Chinese medicine composition are carried into the cells, the transdermal absorption and the continuous action of the cells on the effective components; poloxamer 188 is added as an emulsifier, coconut oil alcohol polyether-7, PPG-1-PEG-9 lauryl glycol ether and PEG-40 hydrogenated castor oil are added to be compounded to be used as a solubilizer, carbomer is added to be used as a thickener, disodium ethylene diamine tetraacetate is added to be used as a chelating agent, the emulsifier and the compounded solubilizer have a synergistic effect, the texture of the clear paste is improved, more effective ingredients of the traditional Chinese medicine are promoted to be dissolved in a medicine film layer, the medicine effect is improved by 58%, the transdermal absorption performance of the skin on the effective ingredients in the clear paste is improved, meanwhile, the compounded solubilizer reduces the dosage of a single solubilizer, and the influence of excessive use of the single solubilizer on the transdermal absorption performance; the imidazolidinyl urea, the methyl hydroxybenzoate and the 2-bromo-2-nitropropane-1, 3-diol are added to be compounded to serve as a preservative, so that the shelf life of the cream is prolonged, the using amount of a single preservative is avoided, and the side effect of excessive use of the single preservative on skin is reduced; sodium hydroxide is added to assist in regulating the flora environment of the skin, prevent skin bacterial and fungal infection and play a role in skin care.

The cream is prepared by taking the traditional Chinese medicine composition for whitening and removing freckles as an effective component, can be externally applied to penetrate into internal circulation through skin, improves and adjusts internal environment, can treat both symptoms and root causes by combining external application, internal application and external application, and can safely and long-term solve the problem of facial spots such as chloasma and the like and prevent the chloasma from easily relapsing.

The preparation method of the whitening and freckle-removing facial cream comprises the following operation steps:

(1) adding carbomer into part of water, soaking for 10-15 hours, homogenizing until carbomer is completely dispersed, adding sodium hydroxide, and mixing uniformly to obtain a mixed material 1 for later use; adding poloxamer 188, sodium hyaluronate and 2-bromo-2-nitropropane-1, 3-diol into the rest water, and uniformly mixing to obtain a mixed material 2 for later use; adding propylene glycol into methyl hydroxybenzoate, and mixing uniformly to obtain a mixed material 3 for later use; adding Cocoaptate-7, PPG-1-PEG-9 lauryl glycol ether, and PEG-40 hydrogenated castor oil into flos Rosae Davuricae oil, and mixing to obtain mixture 4;

(2) adding the mixed material 2 into the mixed material 1, and uniformly mixing to obtain a mixed material 5;

(3) adding radix Curcumae extract, Notoginseng radix extract, radix rehmanniae Preparata extract, semen Persicae extract, radix Ophiopogonis extract, rhizoma Cyperi extract, bupleuri radix extract, Atractylodis rhizoma extract, fructus forsythiae extract, rhizoma Bletillae root extract, Saviae Miltiorrhizae radix extract, radix Paeoniae Rubra extract, radix Saposhnikoviae extract, Poria extract, Carthami flos extract, Glycyrrhrizae radix extract, radix Angelicae sinensis extract, glycerol, Margarita powder, imidazolidinyl urea, and disodium edetate into the mixture 5, and mixing to obtain mixture 6;

(4) adding the mixed material 3 into the mixed material 6, and uniformly mixing to obtain a mixed material 7; adding the mixed material 4 into the mixed material 7, and uniformly mixing to obtain the clear paste.

In the step (1), the homogenizing rotating speed is 25r/min in the homogenizing process of the mixed material 1, and the homogenizing time is 10-15 minutes.

The Chinese medicinal extracts are prepared by the following steps: putting the traditional Chinese medicine raw materials into a traditional Chinese medicine extraction tank, adding 10 times of water, heating and boiling for 3 hours, discharging liquid, and filtering to obtain a traditional Chinese medicine extract for later use.

Functional brief introduction of effective components:

peach kernel: the main effects are removing blood stasis, removing dampness and expanding blood vessels, and the traditional Chinese medicine composition is used for removing freckles, relieving skin pigmentation, promoting blood circulation and accelerating discharge of vivotoxin.

Safflower: the Chinese medicinal composition has the effects of promoting blood circulation, stimulating the menstrual flow, removing blood stasis, removing freckles, dredging channels, eliminating melanin deposited on skin, dredging channels and accelerating detoxification.

Bupleurum root: bitter taste, even smell, slightly cold. The smell is light, the smell is not reduced, and the smell is also non-toxic. Enter the four meridians of Shaoyang and Jueyin. Purging pathogenic factors of liver and gallbladder, relieving stuffiness and oppression in the heart and chest, resolving phlegm stagnation, removing dysphoria with smothery sensation, especially for sores and ulcers, dissipating all blood congealing and qi accumulation of meridians, stopping migraine, stabbing pain in chest and hypochondrium, and activating exterior and interior pathogenic qi to relieve tidal fever. Bupleurum root, radix bupleuri, being introduced between exterior and interior, can reach the meridians and collaterals, so it is used as adjuvant and guiding herb, but it is mild in nature, clear and slightly cold in nature, and good at resolving disputes in the place where it is located, so it is not suitable for use. The bupleurum is used for removing freckles, regulating endocrine, calming the nerves and calming the heart, and can effectively relieve the root cause problem of color spots.

Red peony root: bitter in property and slightly cold in nature, entering liver meridian. Has the main functions of clearing heat and cooling blood, and eliminating blood stasis and relieving pain. Can be used for treating macula due to toxic heat, hematemesis, epistaxis, conjunctival congestion, swelling and pain, liver depression, hypochondriac pain, amenorrhea, dysmenorrhea, abdominal pain, traumatic injury, carbuncle, swelling, and pyocutaneous disease. In the aspect of removing freckles, the red paeony root has the effects of expelling toxin, weakening stains and regulating endocrine at the same time.

Rhizoma cyperi: has the effects of regulating qi, resolving stagnation, regulating menstruation and relieving pain, and can be used for treating stagnation of qi due to depression of liver, distending pain of chest, hypochondrium and abdomen, dyspepsia, menoxenia, amenorrhea, dysmenorrhea, cold hernia, abdominal pain, and breast distending pain. The composition is used in freckle-removing medicines, and also has the effects of adjusting internal secretion, relieving mood fluctuation of patients and facilitating detoxification.

Turmeric root-tuber: pungent, bitter and cold in nature, it enters liver, heart and lung meridians. The main effects are as follows: move qi and remove blood stasis, clear heart fire and relieve depression, promote bile flow and cure jaundice. The product has effects of resolving macula, regulating endocrine, relieving emotion, and removing toxic substance.

Bletilla striata: bitter, sweet, astringent and slightly cold. It enters lung, liver and stomach meridians. Whitening, resolving macula, astringing, stopping bleeding, eliminating swelling, and promoting granulation. Bletilla striata is a good medicine for beauty treatment from old times, is known as whitening faery knotweed, and can treat skin diseases such as acne, tinea corporis, scars and the like. Yun He from Yao Lun treats sore on the face and makes the skin slippery. "Yun He of Ben Cao gang mu" washes black face and removes spots. Has the main effects of promoting cell metabolism, promoting toxin discharge, fading skin color and smoothing skin.

White atractylodes rhizome: bitter and sweet in taste and warm in nature. It enters spleen and stomach meridians. The medical records of the drug property: "have beautiful main face, retain youthful looks and remove spots". The widely-spread traditional Chinese medicine beauty treatment prescription recorded in the medical entrance, namely 'Sanbai decoction', is described as follows: the white atractylodes rhizome can treat spleen deficiency and qi deficiency, tonify qi and blood, whiten and moisten skin, and is suitable for rough skin, sallow complexion, chloasma, pigmentation and the like caused by qi-blood deficiency and cold. The rhizoma Atractylodis Macrocephalae has effects of delaying aging, whitening skin, and inhibiting skin pathogenic fungi such as epidermophyton vaporarum.

Pseudo-ginseng: sweet, slightly bitter and warm in nature and taste. Notoginseng radix enters liver and stomach meridians. The pseudo-ginseng has the effects of clearing heat, calming the liver, nourishing the heart, soothing the nerves, moistening the lung, keeping youth, resisting aging, eliminating and reducing skin wrinkles and chloasma and the like. Is especially suitable for female to care skin, is the most natural product for women, and has the functions of resisting senility, protecting skin, improving skin appearance, softening skin and raising skin elasticity. Mainly promotes blood circulation and cell metabolism and discharges toxin stasis through the blood circulation promoting effect of the pseudo-ginseng.

Prepared rehmannia root: sweet taste and mild nature, and has the effects of nourishing yin, tonifying blood, replenishing vital essence and replenishing marrow. Can be used for treating deficiency of liver-yin and kidney-yin, soreness of waist and knees, hectic fever, night sweat, nocturnal emission, internal heat, diabetes, blood deficiency, sallow complexion, cardiopalmus, menoxenia, giddiness, tinnitus, and premature gray hair. Treating kidney deficiency and blood heat, reducing and eliminating blood stasis, and promoting cell metabolism.

Licorice root: the main effects of the traditional Chinese medicine are to dissipate exterior pathogen, eliminate carbuncle and swelling, relieve sore throat, relieve various drug toxins, remove heat accumulated in stomach and remove pain in ureter, and the effect of removing heat by sweet and cool is also achieved. The moxibustion is warm and tonifying the middle-jiao, mainly has the effects of spleen deficiency and sliding diarrhea, stomach deficiency and thirst, cold and heat cough, and freckle removing medicines which have the effects of strengthening the spleen and stomach, detoxifying and dissipating exterior pathogens and have obvious curative effects on regulating viscera, collapsing and metabolizing melanin.

Chinese angelica: the main effects are enriching blood and promoting blood circulation, regulating menstruation and relieving pain, and relaxing bowel. When the traditional Chinese medicine is used for removing freckles, the effects are taken to regulate endocrine, accelerate detoxification and prevent stains formed by absorption of toxins in vivo by intestinal tracts due to long-time retention. Therefore, the composition has direct efficacy on treating and preventing color spots.

Fructus forsythiae: the functions are mainly used for clearing heat, detoxifying, dissipating stagnation and reducing swelling. It is indicated for warm heat, erysipelas, macula, superficial infection, abscess, swelling, scrofula and stranguria.

Radix ophiopogonis: sweet and slightly bitter in flavor, cold in nature, entering heart, lung and stomach meridians. Has effects of clearing heart fire, moistening lung, nourishing stomach, and promoting fluid production. Can be used for treating febrile disease, impairment of body fluid, asthenia, dysphoria, clearing heart fire, moistening lung, nourishing yin, replenishing vital essence, clearing heat, relieving restlessness, eliminating phlegm, relieving cough, promoting diuresis, promoting fluid production, improving eyesight, and caring skin. Ophiopogon root has the effects of clearing heart fire and relieving restlessness, and can be used for treating heart yin deficiency, dysphoria, insomnia, fever, dysphoria, night sleep restlessness, and deficiency of both lung and kidney yin, manifested by asthenic hectic fever and dysphoria.

Tuckahoe, poria cocos: induce diuresis and drain dampness, invigorate spleen and calm heart. The white poria can strengthen the spleen, has the functions of strengthening the spleen and replenishing qi for qi-deficiency and spleen-weakness patients with chronic diseases, emaciation, hypodynamia, or combined with tiredness and diarrhea, and has mild drug property.

Red sage root: bitter in property and taste, slightly cold, entering heart and liver meridians. Has the effects of activating blood circulation to dissipate blood stasis, stimulating the menstrual flow to relieve pain, clearing away the heart-fire and relieving restlessness, cooling blood and eliminating carbuncle.

Wind prevention: dispelling pathogenic wind, relieving exterior syndrome, eliminating dampness, relieving pain, relieving spasm, relieving itching, and preventing allergy.

The guiding principle for realizing the whitening and freckle-removing effects of the whitening and freckle-removing traditional Chinese medicine composition is as follows: in traditional Chinese medicine, on the basis of internal causes, the chloasma is divided into 'qi stagnation and blood stasis' symptoms, 'spleen deficiency and kidney deficiency' symptoms and 'kidney deficiency' symptoms, and specifically the symptoms are as follows:

qi stagnation and blood stasis: the liver stores blood and governs smoothing flow of qi, regulating qi movement of the whole body, regulating emotional activities, promoting the distribution and metabolism of blood and body fluids, promoting the transportation and transformation functions of the spleen and stomach, coordinating the emission of sperm from male, ovulation of female and menstruation. Liver qi fails to disperse and purge, liver depression is uncomfortable, stagnation of liver qi is easy to cause, qi movement disorder, qi and blood are adverse, and the face cannot be nourished, so that yellow brown spots are generated. It can be said that qi stagnation type and blood stasis type of stasis syndrome are causality, are related to each other, affect each other, and cause the meridian to be obstructed in ventilation and blood circulation, and long-term stagnation of qi and blood turns into heat to burn yin and blood; or qi stagnation may cause disorder of body fluid metabolism, and phlegm turbidity may block the meridians, leading to facial qi-blood disharmony, loss of qi-blood nourishment, retention of phlegm-stasis and turbid qi, and facial skin malnutrition, leading to chloasma. In short, facial poor blood circulation power is caused by qi stagnation, facial qi and blood circulation is delayed slowly, facial blood vessel stasis is caused, metabolic substance deposition in blood vessels and pigmentation form chloasma, and the chloasma is mostly generated in middle-aged women. It is the root of liver failure, qi stagnation and blood stasis.

The symptoms of spleen deficiency and kidney deficiency: spleen deficiency type spleen governs blood to promote transportation and transformation, and spleen is the acquired root, which causes the disease due to failure of spleen to nourish the face. The "the source of the diseases" includes: the five zang organs and six fu organs all have the blood flowing on the face, and the fu-organs and blood flow together to nourish the exterior and interior, indicating that the blood deficiency can lead to disharmony of qi and blood, or astringency or turbidity, which cannot nourish the skin, thus leading to blackening and beautifying. Blood vessels are empty and deficient, and black spots are generated when the face cannot be nourished. Qi deficiency failing to circulate blood, blood stasis stagnating in the face along the meridians, and chloasma. Essence and blood have the same source, essence can generate blood, blood can transform essence, essence is inflated to be vigorous, the face is lustered, otherwise, the face is dark and lusterless. This syndrome is often seen in postpartum women or after abortion, and also can be seen in improper diet, overstrain, preference for five flavors, dysfunction of the spleen in transportation, and failure of qi and blood to nourish the upper part; or, water retention due to earth deficiency, up-diffusion of water and qi and blood failing to warm the body, they can produce black spots. Qi stagnation can be caused by long-term qi deficiency.

Kidney deficiency syndrome: the traditional Chinese medicine theory considers that the kidney is the congenital foundation, mainly stores essence, and the kidney essence is the root of life activities of the human body, the essence and blood play the roles of nourishing and moistening various tissues and organs of the human body, the generation and the transformation of the blood depend on the condition of the kidney essence, and the filling of the kidney essence also depends on the nourishing of the blood. Essence and blood affect each other and nourish each other. Kidney yang, also known as Zhen Yang, is the root of the whole body's yang-qi and plays an important role in promoting the circulation of qi and blood, nourishing and moistening the face, transpiring and gasifying body fluids, and discharging turbid pathogens. Deficient constitutional yang, kidney deficiency in the middle of the year, kidney injury due to prolonged illness, or overstrain of the sexual life, etc., failing to warm and nourish the meridians, cold coagulation and blood stasis, and poor complexion, and because of the loss of true yang, transpiration and gasification are unwarranted, turbid yin is diffused into the complexion, and the complexion becomes dark and lusterless, and the complexion is lost and becomes chloasma. For kidney yin deficiency, kidney water deficiency can not control fire, and deficient fire is flaming upward, resulting in dry fire forming black spots and dry and lusterless color.

In conclusion, the cause mechanism of chloasma is formed and can be attributed to the deficiency and stasis, the chloasma is closely related to the dysfunction of the liver, spleen and kidney, the syndrome differentiation of the traditional Chinese medicine is the dysfunction of the liver, spleen and kidney, and the deficiency of qi and blood and stasis are the basic pathological changes of the chloasma. Stagnation of liver qi, qi stagnation leading to blood stasis; kidney deficiency with dryness, blood heat stagnation and blood stasis; spleen deficiency, qi deficiency, blood deficiency and failure of the driving can also cause stasis; finally, qi and blood can not nourish the face, and the pigment is deposited to form chloasma. Therefore, the treatment of chloasma requires blood circulation activation, blood stasis removal, meridian dredging and qi and blood tonifying.

The whitening and freckle-removing traditional Chinese medicine composition is composed of a radix curcumae extract, a pseudo-ginseng extract, a prepared rehmannia root extract, a peach kernel extract, a radix ophiopogonis extract, a cyperus rotundus extract, a radix bupleuri extract, a bighead atractylodes rhizome extract, a fructus forsythiae extract, a bletilla striata root extract, a salvia miltiorrhiza extract, a radix paeoniae rubra extract, a radix sileris extract, a poria cocos extract, a safflower extract, a liquorice root extract and an angelica sinensis extract, and all the raw materials are synergistic within a limited dosage range, so that the effects of activating blood and dissolving stasis, dredging channels and collaterals, supporting spleen and tonifying deficiency and conditioning endocrine are achieved. The method specifically comprises the following steps: peach kernel extract, safflower extract, angelica extract and pseudo-ginseng extract, and synergistically exert the effect of activating blood; the red peony root extract, the red sage root extract, the cyperus rotundus extract, the curcuma aromatica extract and the forsythia fruit extract synergistically play a role in removing blood stasis; the cyperus rotundus extract synergistically regulates internal secretion and promotes melanin decomposition; the licorice root extract can harmonize the medicines and reduce the toxicity; the divaricate saposhnikovia root is used for harmonizing the medicines, dispelling wind heat, coordinating with other components for promoting blood circulation and removing blood stasis, balancing wind heat and controlling the generation of allergy; radix rehmanniae Preparata extract and Atractylodis rhizoma extract can be used for treating spleen deficiency and kidney deficiency, nourishing yin, invigorating qi and replenishing blood. The radix bupleuri calms mind and calms heart, removes stagnated heat, and lays a foundation for other components to play a role; bletilla striata promotes cell metabolism, discharges toxin and smoothes skin.

Detailed Description

The technical solution of the present invention will be described in detail by specific examples.

Example 1

A traditional Chinese medicine composition for whitening and removing freckles is composed of the following raw materials in parts by weight: 3 parts of curcuma aromatica extract, 3 parts of pseudo-ginseng extract, 4 parts of prepared rehmannia root extract, 6 parts of peach kernel extract, 3 parts of dwarf lilyturf tuber extract, 3 parts of cyperus rotundus extract, 3 parts of bupleurum extract, 4 parts of bighead atractylodes rhizome extract, 3 parts of forsythia fruit extract, 4 parts of bletilla striata root extract, 3 parts of salvia miltiorrhiza extract, 6 parts of radix paeoniae rubra extract, 4 parts of radix sileris extract, 3 parts of poria cocos extract, 3 parts of safflower extract, 3.6 parts of licorice root extract and 3 parts of angelica sinensis extract.

The whitening and freckle-removing facial cream is prepared from the following raw materials in parts by weight: the whitening and freckle-removing traditional Chinese medicine composition comprises 61.6 parts of whitening and freckle-removing traditional Chinese medicine composition, 22 parts of glycerin, 5.2 parts of carbomer, 1884.4 parts of poloxamer, 4 parts of propylene glycol, 0.832 part of sodium hydroxide, 0.8 part of imidazolidinyl urea, 70.3 parts of coco-alcohol polyether, 0.12 part of PPG-1-PEG-9 lauryl glycol ether, 0.06 part of PEG-40 hydrogenated castor oil, 0.44 part of sodium hyaluronate, 0.4 part of methyl hydroxybenzoate, 0.2 part of pearl powder, 0.16 part of 2-bromo-2-nitropropane-1, 3-diol, 0.16 part of disodium ethylene diamine tetraacetate, 0.2 part of rosa multiflora flower oil and 299.248 parts of water.

The preparation method of the whitening and freckle-removing facial cream comprises the following operation steps:

(1) adding carbomer into part of water, soaking for 10-15 hours, homogenizing for 10-15 minutes at the stirring speed of 25r/min until the carbomer is completely dispersed, adding sodium hydroxide, and uniformly mixing to obtain a mixed material 1 for later use; adding poloxamer 188, sodium hyaluronate and 2-bromo-2-nitropropane-1, 3-diol into the rest water, and uniformly mixing at the stirring speed of 25r/min to obtain a mixed material 2 for later use; adding propylene glycol into methyl hydroxybenzoate, and uniformly mixing at a stirring speed of 25r/min to obtain a mixed material 3 for later use; adding Cocoaptate polyether-7, PPG-1-PEG-9 lauryl glycol ether, and PEG-40 hydrogenated castor oil into flos Rosae Davuricae oil, stirring at 25r/min, and mixing to obtain mixture 4;

(2) adding the mixed material 2 into the mixed material 1, and uniformly mixing at a stirring rotating speed of 25r/min to obtain a mixed material 5;

(3) adding radix Curcumae extract, Notoginseng radix extract, radix rehmanniae Preparata extract, semen Persicae extract, radix Ophiopogonis extract, rhizoma Cyperi extract, bupleuri radix extract, Atractylodis rhizoma extract, fructus forsythiae extract, rhizoma Bletillae root extract, Saviae Miltiorrhizae radix extract, radix Paeoniae Rubra extract, radix Saposhnikoviae extract, Poria extract, Carthami flos extract, Glycyrrhrizae radix extract, radix Angelicae sinensis extract, glycerol, Margarita powder, imidazolidinyl urea, and disodium edetate into the mixed material 5, and mixing at 25r/min to obtain mixed material 6;

(4) adding the mixed material 3 into the mixed material 6, and uniformly mixing at a stirring speed of 25r/min to obtain a mixed material 7; adding the mixed material 4 into the mixed material 7, and uniformly mixing at the stirring speed of 25r/min to obtain the clear paste.

The whitening and freckle-removing traditional Chinese medicine composition can also be prepared into a pharmaceutical preparation or a cosmetic preparation, such as a water aqua, a facial mask and the like.

Through detection, the microbiological indexes of the clear paste prepared by the embodiment are as follows: the total number of bacterial colonies, the total number of moulds and yeasts, the faecal coliform group, the staphylococcus aureus and the pseudomonas aeruginosa meet the requirements of the cosmetic hygiene code (2007 edition); hygienic chemical indexes: the contents of mercury, arsenic and lead all meet the requirements of the cosmetic hygiene code (2007 edition).

Example 2

A traditional Chinese medicine composition for whitening and removing freckles is composed of the following raw materials in parts by weight: 2 parts of curcuma aromatica extract, 2 parts of pseudo-ginseng extract, 3 parts of prepared rehmannia root extract, 5 parts of peach kernel extract, 2 parts of dwarf lilyturf tuber extract, 2 parts of cyperus rotundus extract, 2 parts of bupleurum extract, 3 parts of bighead atractylodes rhizome extract, 2 parts of forsythia fruit extract, 3 parts of bletilla striata root extract, 2 parts of salvia miltiorrhiza extract, 5 parts of radix paeoniae rubra extract, 3 parts of radix sileris extract, 2 parts of poria cocos extract, 2 parts of safflower extract, 2.5 parts of licorice root extract and 2 parts of angelica sinensis extract.

The whitening and freckle-removing facial cream is prepared from the following raw materials in parts by weight: the whitening and freckle-removing traditional Chinese medicine composition comprises 60 parts of whitening and freckle-removing traditional Chinese medicine composition, 20 parts of glycerin, 4 parts of carbomer, 1883.5 parts of poloxamer, 3 parts of propylene glycol, 0.5 part of sodium hydroxide, 0.5 part of imidazolidinyl urea, 70.2 parts of coco-alcohol polyether, 0.05 part of PPG-1-PEG-9 lauryl glycol ether, 0.03 part of PEG-40 hydrogenated castor oil, 0.35 part of sodium hyaluronate, 0.3 part of methyl hydroxybenzoate, 0.1 part of pearl powder, 0.1 part of 2-bromo-2-nitropropane-1, 3-diol, 0.1 part of disodium ethylene diamine tetraacetate, 0.3 part of dog rose oil and 295 parts of water.

The preparation method of the whitening and freckle-removing facial cream is the same as that of example 1.

Example 3

A traditional Chinese medicine composition for whitening and removing freckles is composed of the following raw materials in parts by weight: 4 parts of curcuma aromatica extract, 4 parts of pseudo-ginseng extract, 5 parts of prepared rehmannia root extract, 7 parts of peach kernel extract, 4 parts of dwarf lilyturf tuber extract, 4 parts of cyperus rotundus extract, 4 parts of bupleurum extract, 5 parts of bighead atractylodes rhizome extract, 4 parts of forsythia fruit extract, 5 parts of bletilla striata root extract, 4 parts of salvia miltiorrhiza extract, 7 parts of radix paeoniae rubra extract, 5 parts of radix sileris extract, 4 parts of poria cocos extract, 4 parts of safflower extract, 5.5 parts of licorice root extract and 4 parts of angelica sinensis extract.

The whitening and freckle-removing facial cream is prepared from the following raw materials in parts by weight: the whitening and freckle-removing traditional Chinese medicine composition comprises 61.6 parts of whitening and freckle-removing traditional Chinese medicine composition, 22 parts of glycerin, 5.2 parts of carbomer, 1884.4 parts of poloxamer, 4 parts of propylene glycol, 0.832 part of sodium hydroxide, 0.8 part of imidazolidinyl urea, 70.3 parts of coco-alcohol polyether, 0.12 part of PPG-1-PEG-9 lauryl glycol ether, 0.06 part of PEG-40 hydrogenated castor oil, 0.44 part of sodium hyaluronate, 0.4 part of methyl hydroxybenzoate, 0.2 part of pearl powder, 0.16 part of 2-bromo-2-nitropropane-1, 3-diol, 0.16 part of disodium ethylene diamine tetraacetate, 0.2 part of rosa multiflora flower oil and 299.248 parts of water.

The preparation method of the whitening and freckle-removing facial cream is the same as that of example 1.

Clinical effect test:

patient data: the patients with the age of 32-52 years are 3 male patients, 125 female patients and the average age of 36.5 years, and the patients show large-area chloasma on the face.

The treatment method comprises the following steps: the face cream prepared in the embodiment 1 of the invention is applied to the face once in the morning and at night, 28 days are taken as a treatment course, and the treatment effects of the two treatment courses are counted. Meanwhile, patients need to pay attention to the irascibility and the worry, maintain optimistic mood, avoid excessively spicy and hot food stimulation on diet and particularly pay attention to avoid abusing cosmetics during and after treatment.

The curative effect standard is as follows: basically curing: the mottle area is faded by more than 90 percent, and the color basically disappears;

the effect is shown: the area of the mottle fades to be more than 60 percent, and the color obviously becomes lighter;

improvement: the mottle area faded by more than 30% and the color faded;

the ineffectiveness is that the fading area of the color spot is less than or equal to 30 percent, and the color change is not obvious.

The effective rate is counted by the cure and obvious effect.

The treatment results are as follows: after two treatment courses, the 128 patients are cured by 46 patients, 68 patients are obviously effective, 13 patients are improved, 11 patients are basically ineffective, and the effective rate is 89%. No obvious adverse reaction occurs in all cases.

Typical cases are: song Dynasty, women, age 31. The doctor visits 5 months and 28 days in 2014. The facial pigmented spots are mainly complained for 2 years, the front part of the face appears light brown spots in 2 years, the rear range is gradually enlarged, the color is gradually deepened, and the curative effect of the traditional Chinese medicine and the western medicine is not obvious. The self-reported abdominal pain, irritability, chest and hypochondrium distress and distention, poor appetite, irregular menstruation, aggravation of all syndromes before menstruation and breast distending pain. Physical examination: dark brown spots can be seen around the eyes and around the nose, the edges are irregular, the tongue is red with ecchymosis, and the pulse is wiry and smooth. The face cream prepared by the embodiment of the invention is externally applied for 1 time each in the morning and evening every day. The patient is subjected to a double-diagnosis after 7 days, the self-written mood is good, the sleep quality is improved, the spirit is full, and the patient can be cured by continuously using the face cream for 56 days.

Claims (4)

1. The whitening and freckle-removing facial cream is characterized by being prepared from the following raw materials in parts by weight: 60-63 parts of a whitening and freckle-removing traditional Chinese medicine composition, 20-25 parts of glycerin, 4-6 parts of carbomer, 1883.5-5.5 parts of poloxamer, 3-5 parts of propylene glycol, 0.5-1 part of sodium hydroxide, 0.5-1 part of imidazolidinyl urea, 70.2-0.4 part of cocoalcohol polyether, 0.05-0.2 part of PPG-1-PEG-9 lauryl glycol ether, 0.03-0.08 part of PEG-40 hydrogenated castor oil, 0.35-0.55 part of hyaluronic acid, 0.3-0.5 part of methyl hydroxybenzoate, 0.1-0.3 part of pearl powder, 0.1-0.2 part of 2-bromo-2-nitropropane-1, 3-diol, 0.1-0.2 part of disodium edetate, 0.1-0.3 part of rosa multiflora oil and 295-305 parts of water;

the whitening and freckle-removing traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 2-4 parts of radix curcumae extract, 2-4 parts of pseudo-ginseng extract, 3-5 parts of prepared rehmannia root extract, 5-7 parts of peach kernel extract, 2-4 parts of radix ophiopogonis extract, 2-4 parts of cyperus rotundus extract, 2-4 parts of radix bupleuri extract, 3-5 parts of bighead atractylodes rhizome extract, 2-4 parts of fructus forsythiae extract, 3-5 parts of bletilla striata root extract, 2-4 parts of salvia miltiorrhiza extract, 5-7 parts of radix paeoniae rubra extract, 3-5 parts of radix sileris extract, 2-4 parts of poria cocos extract, 2-4 parts of safflower extract, 2.5-5.5 parts of licorice root extract and 2-4 parts of angelica sinensis extract.

2. The whitening and freckle-removing facial cream according to claim 1, wherein the whitening and freckle-removing traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 3 parts of curcuma aromatica extract, 3 parts of pseudo-ginseng extract, 4 parts of prepared rehmannia root extract, 6 parts of peach kernel extract, 3 parts of dwarf lilyturf tuber extract, 3 parts of cyperus rotundus extract, 3 parts of bupleurum extract, 4 parts of bighead atractylodes rhizome extract, 3 parts of forsythia fruit extract, 4 parts of bletilla striata root extract, 3 parts of salvia miltiorrhiza extract, 6 parts of radix paeoniae rubra extract, 4 parts of radix sileris extract, 3 parts of poria cocos extract, 3 parts of safflower extract, 3.6 parts of licorice root extract and 3 parts of angelica sinensis extract.

3. The whitening and freckle-removing facial cream according to claim 2 is prepared from the following raw materials in parts by weight: 61.6 parts of the traditional Chinese medicine composition for whitening and removing freckles, 22 parts of glycerin, 5.2 parts of carbomer, 1884.4 parts of poloxamer, 4 parts of propylene glycol, 0.832 part of sodium hydroxide, 0.8 part of imidazolidinyl urea, 70.3 parts of coco-alcohol polyether, 0.12 part of PPG-1-PEG-9 lauryl glycol ether, 0.06 part of PEG-40 hydrogenated castor oil, 0.44 part of sodium hyaluronate, 0.4 part of methyl hydroxybenzoate, 0.2 part of pearl powder, 0.16 part of 2-bromo-2-nitropropane-1, 3-diol, 0.16 part of disodium ethylenediamine tetraacetate, 0.2 part of rosa multiflora flower oil and 299.248 parts of water.

4. A method for preparing the whitening and freckle-removing cream according to claim 1 or 3, which is characterized by comprising the following steps:

(1) adding carbomer into part of water, soaking for 10-15 hours, homogenizing until carbomer is completely dispersed, adding sodium hydroxide, and mixing uniformly to obtain a mixed material 1 for later use; adding poloxamer 188, sodium hyaluronate and 2-bromo-2-nitropropane-1, 3-diol into the rest water, and uniformly mixing to obtain a mixed material 2 for later use; adding propylene glycol into methyl hydroxybenzoate, and mixing uniformly to obtain a mixed material 3 for later use; adding Cocoaptate-7, PPG-1-PEG-9 lauryl glycol ether, and PEG-40 hydrogenated castor oil into flos Rosae Davuricae oil, and mixing to obtain mixture 4;

(2) adding the mixed material 2 into the mixed material 1, and uniformly mixing to obtain a mixed material 5;

(3) adding radix Curcumae extract, Notoginseng radix extract, radix rehmanniae Preparata extract, semen Persicae extract, radix Ophiopogonis extract, rhizoma Cyperi extract, bupleuri radix extract, Atractylodis rhizoma extract, fructus forsythiae extract, rhizoma Bletillae root extract, Saviae Miltiorrhizae radix extract, radix Paeoniae Rubra extract, radix Saposhnikoviae extract, Poria extract, Carthami flos extract, Glycyrrhrizae radix extract, radix Angelicae sinensis extract, glycerol, Margarita powder, imidazolidinyl urea, and disodium edetate into the mixture 5, and mixing to obtain mixture 6;

(4) adding the mixed material 3 into the mixed material 6, and uniformly mixing to obtain a mixed material 7; and adding the mixed material 4 into the mixed material 7, and uniformly mixing to obtain the face cream.