CN109200191A - Restrain myogenic, Chinese materia medica preparation of light speckles, beautification and white and preparation method thereof - Google Patents
Restrain myogenic, Chinese materia medica preparation of light speckles, beautification and white and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
The present invention provides a kind of Chinese materia medica preparation for restraining myogenic, light speckles, beautification and white, and raw material is composed of the following parts by weight: 10~20 parts of Radix Angelicae Sinensis, 10~20 parts of the bletilla striata, 10~20 parts of the root of Dahurain angelica, 10~20 parts of honeysuckle, 5~10 parts of lavender, 5~10 parts of fructus hippophae, 10~20 parts of Poria cocos, 5~10 parts of ginkgo leaf, 1~5 part of Radix Glycyrrhizae, 1~5 part of four-o'clock seed meal, 1~5 part of apple extract.In addition, the present invention also provides a kind of convergence myogenics, the preparation method of the Chinese materia medica preparation of light speckles, beautification and white.It is simple that the present invention provides convergence myogenic, the Chinese materia medica preparation preparation process of light speckles, beautification and white, safe without toxic side effect, it is non-stimulated to skin, inherently solve the problems, such as that facial colour spot accumulation and face are coarse, and then realize and chloasma, freckle are effectively desalinated, dispelled, achieve the effect that restrain myogenic, light speckles, beautification and white.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of Chinese materia medica preparation and its system for restraining myogenic, light speckles, beautification and white
Preparation Method.
Background technique
With the improvement of living standards, the effect of beauty and skin care is increasingly taken seriously, and people are to skin care item and safety
It is required that also higher and higher, the facial colour spot due to caused by heredity, ultraviolet light irradiation or other reasons, coarse also become of face perplex
The problem of each age level crowd.
Facial colour spot is a kind of chromatodermatosis for betiding face, belongs to " chloasma hepaticum ", " dusty complexion " of traditional Chinese medicine
Equal scopes, facial colour spot are more common with chloasma and freckle.Chinese medicine think facial colour spot mostly because of stagnation of QI due to depression of the liver, blood-head stasis,
Or spleen deficiency precise and tiny, the deficiency of qi and blood that is unable to metaplasia, failure of skin and muscle to be nourished and kidney water cannot make fire, contain in abnormal heat, caused by strongly fragrant resistance skin.Doctor trained in Western medicine
Think mainly due to melanin deposition, and tyrosinase is the Major Enzymes to form melanin.Facial colour spot clinical manifestation is Huang
It exhausts color, light exhaust color and crineous spot or diffusivity patch.It is in irregular shape, obscure boundary Chu, be apt to occur in cheek, forehead, nose,
Face or ear front and back, lip, some expands to entire face, or even involves neck.
There are mercury class compound, parahormone and quinhydrones etc. in early stage for the whitening active ingredients in Whitening, spot skin care item, to the greatest extent
Manage its effect rapidly, whitening effect is obvious, but these compounds, in the presence of easily depositing in vivo, toxicity is big, the safety winds such as irritation
Danger, long-time service can be such that skin sparing barrier is damaged, water and oil balance is broken, skin self-renewal capacity weakens, now extensively
The whitening agent used such as kojic acid, vitamin C and its derivative etc. have security risk, stability bad again or effect show it is unknown
The disadvantages of aobvious.
The Chinese patent application of Publication No. CN103040681A discloses a kind of rose whitening spot-relieving face mask, which is
It is made by the raw material of following parts by weight: Radix Angelicae Sinensis 30~55%, peach kernel 15~28%, the root of Dahurain angelica 12~21%, mung bean 4~13%, white
Poria cocos 1~9%, the bletilla striata 5~10%, rose wate, Rosa Damascana.According to clinical verification, facial mask made of the prescription is for beauty
White light spot significant effect, but because of bergapten contained by the root of Dahurain angelica, xanthotoxin, Isomperatorin the second grade furocoumarin class chemical combination
Object is optical active substance, after they enter body, once it is irradiated by daylight or ultraviolet light, it will cause illuminated skin
Place occurs solar dermatitis, redness, increases with pigment, and what surveillance authority of Ministry of Health of the People's Republic of China in 2002 issued " changes
Cosmetic hygienic practice " in the root of Dahurain angelica be listed in disabling Chinese medicine list, cause the product to be unable to list marketing, application related patents also because
This fails to be authorized.
In order to realize the light speckles, beautification and white launch, applicant passes through numerous studies, it is intended to find substitution root of Dahurain angelica effect
Safe and effective whitening spot-removing, fine skin Chinese materia medica preparation is made in Chinese medicine, and optimization formulation again.
Summary of the invention
The present invention provides a kind of Chinese materia medica preparation for restraining myogenic, light speckles, beautification and white, is made using natural plants, safe and non-toxic pair
Effect fundamentally solves the problems, such as that facial colour spot and face are coarse.
The first purpose of the invention is to provide a kind of convergence myogenics, the Chinese materia medica preparation of light speckles, beautification and white, and raw material is by following
The group of parts by weight is grouped as: 10~20 parts of Radix Angelicae Sinensis, 10~20 parts of the bletilla striata, 10~20 parts of honeysuckle, 5~10 parts of lavender, sand
5~10 parts of spine fruit, 10~20 parts of Poria cocos, 5~10 parts of ginkgo leaf, 1~5 part of Radix Glycyrrhizae, 1~5 part of four-o'clock seed meal, apple extract
1~5 part of object.
Preferably, a kind of Chinese materia medica preparation for restraining myogenic, light speckles, beautification and white, raw material are grouped by the group of following parts by weight
At: 15 parts of Radix Angelicae Sinensis, 15 parts of the bletilla striata, 15 parts of honeysuckle, 8 parts of lavender, 8 parts of fructus hippophae, 15 parts of Poria cocos, 8 parts of ginkgo leaf, Radix Glycyrrhizae 3
Part, 3 parts of four-o'clock seed meal, 3 parts of apple extract.
Preferably, the four-o'clock seed meal partial size is 75~90 μm.
A second object of the present invention is to provide a kind of convergence myogenic, the preparation method of the Chinese materia medica preparation of light speckles, beautification and white, tools
Body follows the steps below to implement:
Step 1,10~20 parts of Radix Angelicae Sinensis, 10~20 parts of the bletilla striata, 10~20 parts of honeysuckle, lavender 5 are weighed in parts by weight
~10 parts, 5~10 parts of fructus hippophae, 10~20 parts of Poria cocos, 5~10 parts of ginkgo leaf, 1~5 part of Radix Glycyrrhizae, four-o'clock seed meal 1~5
Part, 1~5 part of apple extract are spare；
Step 2, Radix Angelicae Sinensis weighed in step 1, the bletilla striata, fructus hippophae, Poria cocos, ginkgo leaf, Radix Glycyrrhizae are mixed, then
It is charged with and is equivalent to Radix Angelicae Sinensis, the bletilla striata, fructus hippophae, Poria cocos, ginkgo leaf, 8~12 times of Radix Glycyrrhizae total weight of water soaked overnight, soak
1.0~2.0h is decocted after bubble, and weighed honeysuckle, lavender in step 1 is added, continues 5~10min of decoction, has decocted
It is filtered after finishing, obtains first time filtrate and filter residue；It is added into filter residue and is equivalent to 8~12 times of filter residue weight of water, decoct 1.0~
2.0h is filtered after decoction, obtains second of filtrate, merges first time filtrate and second of filtrate, is mixed, and is concentrated under reduced pressure at thick
Medicinal extract, gained thick medicinal extract is spare in 4 DEG C of refrigerations；
Step 3, by weighed four-o'clock seed meal, apple extract part in gained Chinese medicine thick medicinal extract in step 2 and step 1
It is uniformly mixed to get the Chinese materia medica preparation of the convergence myogenic, light speckles, beautification and white.
Preferably, pharmaceutically acceptable Chinese materia medica preparation can be conventionally made in the Chinese medicine composition.
Preferably, the pharmaceutical dosage form of the Chinese materia medica preparation be paste, tablet, capsule, granule, oral solution or pill its
In it is any.
In the present invention the effect of each raw material Chinese medicine and pharmacological action:
1, Radix Angelicae Sinensis: it is sweet, pungent, warm, return liver, the heart, the spleen channel.It enriches blood, invigorate blood circulation, menstruction regulating and pain relieving, moisturizing dryness and lubricating intestine.The main all cards of the deficiency of blood；
Irregular menstruation；Menostasis；Dysmenorrhea；Abdominal mass knot is poly-；Metrorrhagia and metrostaxis；Asthenia cold abdominalgia；Flaccidity syndrome and arthralgia syndrome；Numbness；Intestines are dry and shit is difficult；Weight after dysentery with bloody stool；Carbuncle
Subcutaneous ulcer sore；Injury from falling down.Modern pharmacology it is demonstrated experimentally that Radix Angelicae Sinensis can antithrombus formation, anti-inflammatory and antalgic, hypoglycemic, Hepatoprotective cholagogue,
It enriches blood, anti-uterine myometrium, anti-arrhythmia, anti-aging.
2, the bletilla striata: it is bitter, sweet, puckery, it is slightly cold.Return lung, liver, stomach meridian.Astringing to arrest bleeding, detumescence and promoting granulation.For spitting blood, spit blood, outside
Hurt bleeding, sore swollen toxin, chapped skin.Modern pharmacology is it is demonstrated experimentally that the bletilla striata has protection stomach lining, antibacterial, anticancer and hemostasis
Effect.
3, honeysuckle: it is cold in nature, it is sweet in flavor, enter lung, the heart, stomach meridian.Have effects that clearing heat and detoxicating, anti-inflammatory, qi-restoratives treats wind, cures mainly
Disease, warm disease heating under turgor, the diseases such as heat toxin large carbuncle and tumour.Modern pharmacology it is demonstrated experimentally that honeysuckle have resisting pathogenic microbes,
Anti-inflammatory and antipyretic, booster immunization function, central excitation, reducing blood lipid and the effect of antiendotoxin.
4, lavender: have effects that benefiting stomach and stopping pain, clearing heat and detoxicating, adjusting is endocrine.Modern pharmacology is it is demonstrated experimentally that smoke clothing
Grass has the function of tranquilizing soporific, spasmolysis, antibacterial, neuroprotection, lipid-loweringing, moreover it is possible to treat that cardiovascular function is not complete and neurosis；
Lavender can be clearing heat and detoxicating, cleaning skin, controls oil, freckle removing and whitening, and the tender skin of anti-wrinkle, eye haustra -dsipelling black eye are gone back
Have and promotes the skin-protecting functions such as regeneration of damaged tissue recovery；Lavender powder can treat whelk, nourish healthy hair, and analgesic is calm, alleviates
Nerve adjusts endocrine, skin maintenance and cosmetic benefits, calms the nerves calm, desalinates scar, go acne print, improve sleep, improve women's diseases, eliminates
It is dejected.
6, fructus hippophae: warm-natured, sweet,sour and puckery taste enters stomach, spleen, the heart channel of Hang-Shaoyin.With promoting blood circulation scattered silt, reduce phlegm and widen breast, good efficacy to suffering from a deficiency of the kidney, life
The benefits of saliva quenches the thirst, clearing away heat to stop diarrhea.For coughing with a lot of sputum, indigestion, dyspeptic abdominalgia, falls and flutter that the stasis of blood is swollen, blood stasis closed.Modern pharmacology
Research has shown that fructus hippophae has preventive and therapeutic effect to cardiovascular disease, hepatopathy and stomach trouble, additionally it is possible to beauty and skin care, anti-aging, anticancer,
It is also effective in cure to burn, scald.
7, Poria cocos: property slightly sweet flavor is flat, enters the heart, lung, the spleen channel.With eliminating dampness and diuresis, the effect of strengthening the spleen and stomach, antitoxic heart-soothing and sedative.
Difficult urination, edema swelling can be controlled, sip and cough is vomitted inverse, vomiting during early pregnancy, diarrhea, spermatorrhea, stranguria with turbid discharge, palpitation with fear, the diseases such as amnesia.Modern medicine
Reason research has shown that Poria cocos has the function of calmness, diuresis, antitumor anticancer, additionally it is possible to antibacterial, enhancing immunity of organisms, to the heart
Vascular system also has certain effect.
8, ginkgo leaf: it is sweet, bitter, puckery, it puts down.Distributed in heart and lung channels.Activating microcirculation and removing stasis medicinal, remove obstruction in channels to relieve pain, astringing lung-QI is relievingd asthma.Modern pharmacology is ground
Study carefully proof, ginkgo leaf has certain probability to improve memory, though ginkgo leaf can promote blood circulation, prevents cardiovascular disease, ginkgo mentions
Taking object is yellow glucoside, amino acid and the Amino acid synthesis collagen with very strong removing free radical and antioxidation, in ginkgo leaf
Proteins inhibit melanin growth, skin gloss and elasticity are kept to play no small effect to human body beauty treatment；In addition, ginkgo
Leaf has remarkable result to the chronic schizophrenia based on negative symptoms, also there is certain effect to senile dementia.
9, Radix Glycyrrhizae: mild-natured, sweet in flavor, return 12 warps.It invigorates the spleen and benefits qi, grows cough moistening lung, emergency removing toxic substances, hundred medicines of reconciliation.Raw master
Control abscess of throat, pain subcutaneous ulcer sore, gastrointestinal ulceration and solution poisoning of drug, food poisoning etc.；Honey toast cures mainly spleen and stomach function decline, stool
It is half congealed thin, fever out of strength and cough, palpitaition etc..Modern pharmacological studies have shown that Radix Glycyrrhizae has antiacid and alleviation gastrointestinal smooth muscle spasm
Effect；There are also anti-inflammatory, anti-allergic effects for Radix Glycyrrhizae, can protect the throat and tunica mucosa tracheae of inflammation；The Radix Glycyrrhizae extracted from Radix Glycyrrhizae is yellow
Ketone can uvioresistant, the activity of tyrosinase can be inhibited, can also improve the skin of coarse, water shortage, inflammation.
10, facial abnormal pigmentary deposit on the skin mole acne can four-o'clock seed meal: be gone.
11, apple extract: containing abundant carbohydrate, protein, fat, vitamin C, pectin, tannic acid, organic acid and
Calcium, phosphorus, iron, the minerals such as potassium.Have effects that toxin expelling, in addition to this it also has exclusion salinity, it reduces blood pressure, de-cholesterol,
The effects of stimulation enterocinesia, diuresis defaecation；The adjustable human physiological functions of pectin in apple have anti-oxidation function；Apple
Fruit polyphenol has plurality of health care functions, and such as pre- anti-caries, prevent allergic reaction, is antitumor preventing hypertension；Anti- mutation, obstruction
The physiological functions such as ultraviolet radiation absorption, the extracting solution of apple can also eliminate facial freckle, the effect of tool removal dead skin, skin whitening.
Chinese materia medica preparation side's solution of the present invention:
Using Radix Angelicae Sinensis, the bletilla striata, honeysuckle, Poria cocos as monarch drug in a prescription in the present invention, enrich blood, activating blood and clearing heat removing toxic substances, excreting dampness invigorating the spleen；It smokes
Clothing grass, ginkgo leaf, fructus hippophae are ministerial drug, and principal drug assistance is clearing heat and detoxicating, activating microcirculation and removing stasis medicinal, invigorating the spleen function；Monarch drug in a prescription and ministerial drug can improve skin
Skin condition increases skin vitality, removes free radical and peroxide in skin, and can inhibit tyrosinase activity, and prevents junket
Propylhomoserin hydroxylation, reduces the generation of melanin, so that facial colour spot is effectively removed or desalinates, and the bletilla striata has effects that myogenic, it can be thin
Greasy skin；Radix Glycyrrhizae, four-o'clock seed meal, apple extract are adjutant altogether, and Radix Glycyrrhizae can invigorate the spleen and benefit qi, emergency is detoxified, coordinating the drug actions of a prescription,
And to skin play the role of moisturizing, uvioresistant, improve it is coarse, apple extract can toxin expelling defaecation, anti-oxidant, four-o'clock seed
Powder can dispel facial abnormal pigmentary deposit on the skin mole acne.All medicines share is enriched blood, promoting blood circulation, invigorating the spleen to clear away damp pathogen, treats deficiency of blood sallow complexion, and can press down
Tyrosinase activity processed prevents melanin deposition, inherently solves the problems, such as that facial colour spot deposits, can also improve coarse, scarce
Water, inflammation skin.
Compared with prior art, the beneficial effects of the present invention are:
1, it is looked into the root of Dahurain angelica and is seen as cosmetic good merchantable brand, function of the history tree ancient books and records mostly about the root of Dahurain angelica in terms of beauty from ancient capital
The record of effect and mechanism claims its " long skin is moistened, and face rouge can be made " if Shennong's Herbal.The document report root of Dahurain angelica is in beauty
Application in prescription occupy first of all medicines, proves the first beautiful total 1974 of the roots of Dahurain angelica according to the 38 Chinese medical books treatments of Wen little Ping access
Hold in prescription, frequency of use is up to 207 times, and wherein beauty and health care side there are 100 head, and beauty disease side there are 107 head, wherein external application side
There are 169 head.It can be seen that the root of Dahurain angelica truly has its effect in terms of beauty, the status in beauty prescription is to be difficult to be substituted.The present invention exists
On the basis of the Chinese patent application of Publication No. CN103040681A discloses a kind of rose whitening spot-relieving face mask, re-optimization
Prescription, removes this important effective component of the root of Dahurain angelica, re-optimization prescription, and monarch drug in a prescription was by invigorating blood circulation originally, and enriching blood, myogenic pain relieving is worked as
Return, peach kernel, the root of Dahurain angelica are adjusted to Radix Angelicae Sinensis, the bletilla striata, honeysuckle, Poria cocos, the reduction of Radix Angelicae Sinensis dosage, the increase of Poria cocos dosage, enhancing heat-clearing solution
The effect of poison, excreting dampness invigorating the spleen.Rose is changed to lower-cost lavender, while increasing fructus hippophae, apple extract, purple
Jasmine seed meal, and with Radix Glycyrrhizae mediation property of medicine, creative provides the new Chinese materia medica preparation of convergence myogenic, Whitening, spot, matches
Fang Heli, effective component extracts completely after optimum preparation condition, gained Chinese materia medica preparation have enrich blood, activating microcirculation and removing stasis medicinal, invigorating the spleen to clear away damp pathogen,
The effect of restraining myogenic, clinical efficacy is even better than rose whitening spot-relieving face mask, has no toxic side effect, safe good effect.
2, the present invention restrains myogenic, the Chinese materia medica preparation of Whitening, spot can improve skin condition, increases skin vitality, promotes skin
Skin blood circulation, and can inhibit tyrosinase activity, the generation of melanocyte is prevented, to effectively remove or desalinate facial color
Spot, and can fine and smooth skin, the problem of improving coarse skin, water shortage, inflammation.
Specific embodiment
In order to enable those skilled in the art to more fully understand, technical solution of the present invention is practiced, below with reference to specific
The invention will be further described for embodiment, but illustrated embodiment is not as a limitation of the invention.
Radix Angelicae Sinensis used in various embodiments of the present invention, the bletilla striata, honeysuckle, lavender, fructus hippophae, Poria cocos, ginkgo leaf, Radix Glycyrrhizae,
Four-o'clock seed meal, apple extract (Shaanxi Ang Sheng biological medicine Science and Technology Ltd.) are commercially available, the test method, such as
It is conventional method without specified otherwise.
Embodiment 1
A kind of Chinese materia medica preparation for restraining myogenic, light speckles, beautification and white, raw material are composed of the following parts by weight: Radix Angelicae Sinensis 10
Part, 10 parts of the bletilla striata, 10 parts of honeysuckle, 5 parts of lavender, 5 parts of fructus hippophae, 10 parts of Poria cocos, 5 parts of ginkgo leaf, 1 part of Radix Glycyrrhizae, four-o'clock
1 part of seed meal, 1 part of apple extract.
It is specifically implemented according to the following steps:
Step 1, weigh in parts by weight 10 parts of Radix Angelicae Sinensis, 10 parts of the bletilla striata, 10 parts of honeysuckle, 5 parts of lavender, 5 parts of fructus hippophae,
10 parts of Poria cocos, 5 parts of ginkgo leaf, 1 part of Radix Glycyrrhizae, 1 part of four-o'clock seed meal, 1 part of apple extract, it is spare；
Step 2, Radix Angelicae Sinensis weighed in step 1, the bletilla striata, fructus hippophae, Poria cocos, ginkgo leaf, Radix Glycyrrhizae are mixed, then
It is charged with and is equivalent to Radix Angelicae Sinensis, the bletilla striata, fructus hippophae, Poria cocos, ginkgo leaf, 8 times of Radix Glycyrrhizae total weight of water soaked overnight, impregnated
1.0h is decocted after finishing, weighed honeysuckle, lavender in step 1 is added, continues to decoct 5min, filter after decoction, obtains the
First-time filtrate and filter residue；It is added into filter residue and is equivalent to 8 times of filter residue weight of water, decocted 1.0h, filtered after decoction, obtain the
Secondary filtrate merges first time filtrate and second of filtrate, mixes, and is concentrated under reduced pressure into thick medicinal extract, and gained thick medicinal extract is cold in 4 DEG C
It hides spare；
Step 3, gained Chinese medicine thick medicinal extract in step 2 is mixed with four-o'clock seed meal weighed in step 1, apple extract
It closes uniformly to get the convergence myogenic of putty-type, the Chinese materia medica preparation of light speckles, beautification and white.
Preferably, the four-o'clock seed meal partial size is 75 μm.
Embodiment 2
A kind of Chinese materia medica preparation for restraining myogenic, light speckles, beautification and white, raw material are composed of the following parts by weight: Radix Angelicae Sinensis 20
Part, 20 parts of the bletilla striata, 20 parts of honeysuckle, 10 parts of lavender, 10 parts of fructus hippophae, 20 parts of Poria cocos, 10 parts of ginkgo leaf, 5 parts of Radix Glycyrrhizae, purple jasmine
5 parts of jasmine seed meal, 5 parts of apple extract.
It is specifically implemented according to the following steps:
Step 1,20 parts of Radix Angelicae Sinensis, 20 parts of the bletilla striata, 20 parts of honeysuckle, 10 parts of lavender, fructus hippophae 10 are weighed in parts by weight
Part, 20 parts of Poria cocos, 10 parts of ginkgo leaf, 5 parts of Radix Glycyrrhizae, 5 parts of four-o'clock seed meal, 5 parts of apple extract, it is spare；
Step 2, Radix Angelicae Sinensis weighed in step 1, the bletilla striata, fructus hippophae, Poria cocos, ginkgo leaf, Radix Glycyrrhizae are mixed, then
It is charged with and is equivalent to Radix Angelicae Sinensis, the bletilla striata, fructus hippophae, Poria cocos, ginkgo leaf, 12 times of Radix Glycyrrhizae total weight of water soaked overnight, impregnate
After decoct 2.0h, weighed honeysuckle, lavender in step 1 is added, continues to decoct 10min, filters, obtain after decoction
First time filtrate and filter residue；Into filter residue, addition is equivalent to 12 times of filter residue weight of water, decocts 2.0h, filters after decoction,
Second of filtrate is obtained, first time filtrate and second of filtrate are merged, is mixed, is concentrated under reduced pressure at thick medicinal extract, by gained thick medicinal extract in 4
DEG C refrigeration is spare；
Step 3, gained Chinese medicine thick medicinal extract in step 2 is mixed with four-o'clock seed meal weighed in step 1, apple extract
Conjunction is uniform, and appropriate amount of auxiliary materials is added, and mixes, granulation, is sieved, and drying is to get the convergence myogenic of bead dosage form, the Chinese medicine of light speckles, beautification and white
Preparation.
Preferably, the four-o'clock seed meal partial size is 90 μm.
Embodiment 3
A kind of Chinese materia medica preparation for restraining myogenic, light speckles, beautification and white, raw material are composed of the following parts by weight: Radix Angelicae Sinensis 15
Part, 15 parts of the bletilla striata, 15 parts of honeysuckle, 8 parts of lavender, 8 parts of fructus hippophae, 15 parts of Poria cocos, 8 parts of ginkgo leaf, 3 parts of Radix Glycyrrhizae, four-o'clock
3 parts of seed meal, 3 parts of apple extract.
It is specifically implemented according to the following steps:
Step 1, weigh in parts by weight 15 parts of Radix Angelicae Sinensis, 15 parts of the bletilla striata, 15 parts of honeysuckle, 8 parts of lavender, 8 parts of fructus hippophae,
150 parts of Poria cocos, 8 parts of ginkgo leaf, 3 parts of Radix Glycyrrhizae, 3 parts of four-o'clock seed meal, 3 parts of apple extract, it is spare；
Step 2, Radix Angelicae Sinensis weighed in step 1, the bletilla striata, fructus hippophae, Poria cocos, ginkgo leaf, Radix Glycyrrhizae are mixed, then
It is charged with and is equivalent to Radix Angelicae Sinensis, the bletilla striata, fructus hippophae, Poria cocos, ginkgo leaf, 10 times of Radix Glycyrrhizae total weight of water soaked overnight, impregnate
After decoct 1.5h, weighed honeysuckle, lavender in step 1 is added, continues to decoct 8min, filters, obtain after decoction
First time filtrate and filter residue；Into filter residue, addition is equivalent to 10 times of filter residue weight of water, decocts 1.5h, filters after decoction,
Second of filtrate is obtained, first time filtrate and second of filtrate are merged, is mixed, is concentrated under reduced pressure at thick medicinal extract, by gained thick medicinal extract in 4
DEG C refrigeration is spare；
Step 3, by weighed four-o'clock seed meal, apple extract part in gained Chinese medicine thick medicinal extract in step 2 and step 1
It is uniformly mixed, appropriate amount of auxiliary materials is added, mix, granulation, be sieved, it is dry, then by particulate matter obtained through further tabletting, it is dry,
Up to the convergence myogenic of tablet form, the Chinese materia medica preparation of light speckles, beautification and white.
Preferably, the four-o'clock seed meal partial size is 82 μm.
Clinical research data
Examples 1 to 3 has prepared the Chinese materia medica preparation of the convergence myogenic, light speckles, beautification and white that work well, due to embodiment 1
~3 prepare substantially parallel for restraining myogenic, the traditional Chinese medicine effect of light speckles, beautification and white, therefore prepare only with embodiment 1
Chinese materia medica preparation out is illustrated effect of the invention, and control group 1 selects the China of Publication No. CN103040681A specially
Benefit application discloses a kind of rose whitening spot-relieving face mask formula, and control group 2 selects above-mentioned rose whitening spot-relieving face mask formula to remove
The root of Dahurain angelica.
1, data and method
1.1, general information
All tested cases are both from Shaanxi affiliated hospital of university of TCM in September, 2016 in May, 2018 in test
Medical patient, be women, health, no severe psychiatric nervous symptoms, acute, chronic disease history, year without major system
Age 25~46 years old, average (34 ± 5.32) year.There are the qi and bloods such as different degrees of menstrual disorder, insomnia, internal organs, channels and collaterals when treating
Symptom.Patient is divided into 3 age groups and carries out color spot treatment, wherein 25~32 years old 108 people of age group, 32~39 years old age group
102 people, 39~46 years old 111 people of age group, 3 every group of age groups be divided equally at random respectively again 3 groups respectively as example 1 group and
Control group 1 and control group 2.From there is color spot by treatment time most short person 2 months, in more than 5 years of the longest, every group of patient is in example
Number, color spot degree, color spot time etc. occur, there was no significant difference (P > 0.05), is comparable.
1.2, method
External application: the Chinese materia medica preparation prepared in embodiment 1 is taken sooner or later daily and spreads on face in right amount, is rushed after half an hour with clear water
It washes, symptom continues medication 1 month after disappearing.3 months are 1 course for the treatment of, and all patients use three courses for the treatment of.It is provided using the present invention
Chinese materia medica preparation while, patient carry out sun-proof work, keep your mood, daily life system rule, eat maror less.
2, efficacy assessment standard
Effective: the normal color of menstruation recovery, spot subside, and skin attenuates, and greasy, water is tender, and color spot disappears without rebound, inflammation.
Effective: menstruation recovery is normal, and pachylosis, drying are obviously improved, and color spot desalination, color spot is without obvious rebound, inflammation
Slow down.
It is invalid: without significant change before menstruation, inflammation and color spot and treatment.
3, statistical method
It is analyzed using SPSS17.0 statistical software, is compared before and after measurement data using paired t-test, the group of measurement data
Between compare using independent samples t test, the comparison among groups of enumeration data use x2It examines.
4, result
After treatment, different groups divide age bracket curative effect to be shown in Table 1.
The different groups of table 1 divide age bracket clinical observation on the therapeutic effect result
The results show that 3 age groups have significant difference, wherein 25~32 years old age group cures 26 (72.2%) examples,
Compared with 32~39 years old and 39~46 years old age group, have significant difference (P < 0.05)；Age group cures 17 within 32~39 years old
(50%) example has significant difference (P < 0.05) compared with 39~46 years old age group；Age group cures 14 within 39~46 years old
(29.7%) example, 25~32 years old age group is compared with 32~39 years old age group total effective rate, there was no significant difference (P >
0.05), but compared with 39~46 years old age group total effective rate, have significant difference (P < 0.05).Convergence provided by the invention
Myogenic, light speckles, beautification and white Chinese materia medica preparation have enrich blood, activating microcirculation and removing stasis medicinal, promote skin blood circulation, effectively remove or desalinate face
The effect of color spot, and the problem of coarse skin, water shortage, inflammation can be improved.
1 group of different age group of embodiment of the present invention total effective rate that is averaged is 80.3%, and 1 different age group of control group is average
Total effective rate is 69.1%, and 2 different age group of control group is averaged total effective rate only 39.2%.Control group 1 and control group 2 and this hair
Bright example 1 group is compared, and has significant difference, and of the present invention group is substantially better than control group 1 and control group 2.
It should be noted that involved in claims of the present invention when numberical range, it is thus understood that each numberical range
Any one numerical value can be selected between two endpoints and two endpoints, due to step method and the Examples 1 to 3 phase of use
Together, it repeats in order to prevent, the present invention describes preferred embodiment, and once a person skilled in the art knows basic wounds
The property made concept, then additional changes and modifications may be made to these embodiments.So the following claims are intended to be interpreted as includes
Preferred embodiment and all change and modification for falling into the scope of the invention.
Obviously, various changes and modifications can be made to the invention without departing from essence of the invention by those skilled in the art
Mind and range.In this way, if these modifications and changes of the present invention belongs to the range of the claims in the present invention and its equivalent technologies
Within, then the present invention is also intended to include these modifications and variations.
Claims (6)
1. the Chinese materia medica preparation of a kind of convergence myogenic, light speckles, beautification and white, which is characterized in that its raw material is grouped by the group of following parts by weight
At: 10~20 parts of Radix Angelicae Sinensis, 10~20 parts of the bletilla striata, 10~20 parts of honeysuckle, 5~10 parts of lavender, 5~10 parts of fructus hippophae, Poria cocos
10~20 parts, 5~10 parts of ginkgo leaf, 1~5 part of Radix Glycyrrhizae, 1~5 part of four-o'clock seed meal, 1~5 part of apple extract.
2. the Chinese materia medica preparation of convergence myogenic according to claim 1, light speckles, beautification and white, which is characterized in that its raw material is by following
The group of parts by weight is grouped as: 15 parts of Radix Angelicae Sinensis, 15 parts of the bletilla striata, 15 parts of honeysuckle, 8 parts of lavender, 8 parts of fructus hippophae, 15 parts of Poria cocos,
8 parts of ginkgo leaf, 3 parts of Radix Glycyrrhizae, 3 parts of four-o'clock seed meal, 3 parts of apple extract.
3. the Chinese materia medica preparation of convergence myogenic according to claim 1 or 2, light speckles, beautification and white, which is characterized in that the four-o'clock
Seed meal partial size is 75~90 μm.
4. the preparation method of the Chinese materia medica preparation of convergence myogenic according to claim 1 to 3, light speckles, beautification and white, feature exist
In being specifically implemented according to the following steps:
Step 1,10~20 parts of Radix Angelicae Sinensis, 10~20 parts of the bletilla striata, 10~20 parts of honeysuckle, lavender 5~10 are weighed in parts by weight
Part, 5~10 parts of fructus hippophae, 10~20 parts of Poria cocos, 5~10 parts of ginkgo leaf, 1~5 part of Radix Glycyrrhizae, 1~5 part of four-o'clock seed meal, apple
It is 1~5 part of berry extract, spare；
Step 2, Radix Angelicae Sinensis weighed in step 1, the bletilla striata, fructus hippophae, Poria cocos, ginkgo leaf, Radix Glycyrrhizae are mixed, then toward it
Middle addition is equivalent to Radix Angelicae Sinensis, the bletilla striata, fructus hippophae, Poria cocos, ginkgo leaf, 8~12 times of Radix Glycyrrhizae total weight of water soaked overnight, has impregnated
1.0~2.0h is decocted after finishing, and is added weighed honeysuckle, lavender in step 1, is continued 5~10min of decoction, decoction finishes
After filter, obtain first time filtrate and filter residue；It is added into filter residue and is equivalent to 8~12 times of filter residue weight of water, decoct 1.0~
2.0h is filtered after decoction, obtains second of filtrate, merges first time filtrate and second of filtrate, is mixed, and is concentrated under reduced pressure at thick
Medicinal extract, gained thick medicinal extract is spare in 4 DEG C of refrigerations；
Step 3, gained Chinese medicine thick medicinal extract in step 2 is mixed with four-o'clock seed meal weighed in step 1, apple extract
It is even to get it is described convergence myogenic, light speckles, beautification and white Chinese materia medica preparation.
5. the preparation method of the Chinese materia medica preparation of convergence myogenic according to claim 4, light speckles, beautification and white, which is characterized in that institute
Pharmaceutically acceptable Chinese materia medica preparation can be conventionally made by stating Chinese materia medica preparation.
6. the preparation method of the Chinese materia medica preparation of convergence myogenic according to claim 5, light speckles, beautification and white, which is characterized in that institute
The pharmaceutical dosage form for stating Chinese materia medica preparation is paste, tablet, capsule, granule, oral solution or any one kind of pill.
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