CN105560894A

CN105560894A - Traditional Chinese medicine composition for treating allergic cheilitis and preparation method

Info

Publication number: CN105560894A
Application number: CN201610092926.7A
Authority: CN
Inventors: 况晓文
Original assignee: JIAOZHOU PEOPLE'S TRADITIONAL CHINESE MEDICINE HOSPITAL
Current assignee: JIAOZHOU PEOPLE'S TRADITIONAL CHINESE MEDICINE HOSPITAL
Priority date: 2016-02-20
Filing date: 2016-02-20
Publication date: 2016-05-11

Abstract

The invention discloses a traditional Chinese medicine composition for treating the allergic cheilitis. The composition is characterized by being prepared from, by weight, 5-8 parts of honeysuckle, 5-8 parts of periostracum cicada, 5-8 parts of perilla frutescens, 3-5 parts of purslane, 3-5 parts of radix angelica sinensis, 3-5 parts of rhizoma chuanxiong, 3-5 parts of dried radix rehmanniae, 3-5 parts of red peony roots, 3-5 parts of cortex moutan, 3-5 parts of scrophulariae, 3-5 parts of radix ophiopogonis, 3-5 parts of dendrobium, 3-5 parts of ephedra, 3-5 parts of amur cork-trees, 1-2 parts of talcum, 3-5 parts of radix angelicae dahuricae, 3-5 parts of radix platycodi, 3-5 parts of salviae miltiorrhizae, 5-8 parts of rhodiola, 3-5 parts of bupleurum and 1-2 parts of liquorice roots. The composition treats both symptoms and root causes and is high in treatment effect, high in curative effect, free of toxic and side effects and free of adverse reaction.

Description

A kind of Chinese medicine composition and preparation method for the treatment of allergic cheilitis

Technical field

The invention belongs to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine composition and preparation method for the treatment of allergic cheilitis.

Background technology

Irritated cheilitis refers to that the people with allergic constitution is under the impact being subject to the many factors such as weather, illumination, contact lipstick, pungent, medicine, occur in the decortication at lip position, pruritus, redness, serious cause vesicle, waste rotten, sepage, the anaphylactic reaction such as incrustation, and present recurrent exerbation, protracted course of disease, disease cycle such as to shorten gradually at the feature.

Allergic cheilitis has been divided into multiple clinically, wherein with contact cheilitis and actinic cheilitis the most typical.Expert says that these two kinds of diseases are similar in mechanism, is all the allergic inflammation at lip position.One is irritated to contactant, and one is irritated to light, but Symptoms differs from one another.Diseased region and the contact area of contact cheilitis are unanimous on the whole, fall ill after thigmic stimulus thing in a few hours or a few days, can occur Mucosa of lip swelling, vesicle, even rotten to the corn incrustation, namely alleviate gradually to recovery from illness after general disengaging stimulus object.In acute stage, actinic cheilitis also can occur that lip swelling is even rotten to the corn, but seldom occur vesicle, and with congested or hemorrhage more obvious.

There is allergic cheilitis, except this maximum factor of allergic constitution, various mechanical stimulus, infective agent, malnutrition, comprise the attack degree that inherited genetic factors, anxious state of mind etc. all directly may have influence on allergic cheilitis, therefore, according to the common cause and the symptom characteristic that cause allergic cheilitis, summarize again following several kind the most common:

Cheilitis simplex: the weather that often place's what universe is dry, under cold wind blows, causes lip mucosa moisture retention to be deteriorated, and easily peels, peels off, splits.

Exfoliation cheilitis: the good patient sent out in atopic dermatitis or seborrheic dermatitis, may irradiate or touch pungent relevant, common what lower lip with sunlight, mainly serious in cardinal symptom with bits of peeling, fall.

Eczmatous cheilitis: modal example is the lip pomade cheilitis caused that rouges, this is because of to the pigment in lipstick or dyestuff, or lanoline in lip-stick or drug-induced allergy, this kind of patient goes up lower lip usually all can have symptom, an other Xing Shi solar cheilitis, namely long-term under burning sun movable or worker, under ultraviolet chronic stimulation, cause lower lip to become paler, atrophy of epidermis, be full of cracks, even likely develop into malignant change.

Allergic cheilitis belongs to difficult disease clinically, and most of patient with slight symptoms can reach rehabilitation goal after simple western medical treatment, and some medium and heavy patients, if be only rely on western medicine, therapeutic effect often can not be satisfactory.Therefore, active and effective clinical treatment is necessary, is also to be badly in need of, and can not only alleviate the misery of patient, can also shorten disease time, patient is tormented from disease.The main western medicine medicine of allergic cheilitis has immunosuppressant, antihistaminic, glucocorticoid, irritated mediator antagonistic, calcium class medicine etc., western medical treatment can only relief of symptoms in the short time, the easy recurrent exerbation of the state of an illness, and side effect is more, unsuitable prolonged application, is difficult to remove ailing tangling.

Summary of the invention

The object of the invention is to overcome above-mentioned technical problem and provide a kind for the treatment of both the principal and secondary aspects of a disease, evident in efficacy, relatively cheap, have no side effect, the Chinese medicine composition for the treatment of allergic cheilitis with strong points.

Another object of the present invention is to the preparation method that above-mentioned Chinese medicine composition is provided.

For achieving the above object, the present invention adopts following technical scheme: a kind of Chinese medicine composition for the treatment of allergic cheilitis, comprises following component by weight: Flos Lonicerae 5-8 part, Periostracum Cicadae 5-8 part, Folium Perillae 5-8 part, Herba Portulacae 3-5 part, Radix Angelicae Sinensis 3-5 part, Rhizoma Chuanxiong 3-5 part, Radix Rehmanniae 3-5 part, Radix Paeoniae Rubra 3-5 part, Cortex Moutan 3-5 part, Radix Scrophulariae 3-5 part, Radix Ophiopogonis 3-5 part, Herba Dendrobii 3-5 part, Herba Ephedrae 3-5 part, Cortex Phellodendri 3-5 part, Talcum 1-2 part, Radix Angelicae Dahuricae 3-5 part, Radix Platycodonis 3-5 part, Radix Salviae Miltiorrhizae 3-5 part, Radix Rhodiolae 5-8 part, Radix Bupleuri 3-5 part, Radix Glycyrrhizae 1-2 part.

The preparation method of above-mentioned treatment allergic cheilitis Chinese medicine composition, comprises the following steps:

(1) take each medicine by prescription, extracting honeysuckle, Radix Rhodiolae, Herba Portulacae, Radix Paeoniae Rubra are ground into fine powder, sieve, mixing; Get Radix Angelicae Sinensis, Rhizoma Chuanxiong power is broken into coarse powder, adopt CO2 supercritical methanol technology to extract volatile oil, add beta-schardinger dextrin-and make clathrate, medicinal residues are for subsequent use;

(2) get the Radix Rehmanniae again, Radix Scrophulariae, Radix Ophiopogonis, Radix Platycodonis, Radix Salviae Miltiorrhizae powder be broken into coarse powder, extract secondary with 50% alcohol heating reflux, each 1 hour, filter, merging filtrate, reclaim ethanol and be also condensed into thick paste, medicinal residues are for subsequent use;

(3) get Cortex Phellodendri, Periostracum Cicadae, Folium Perillae, Cortex Moutan, Herba Dendrobii, Herba Ephedrae, Talcum, the Radix Angelicae Dahuricae, Radix Bupleuri, Radix Glycyrrhizae and step 1, step 2 medicinal residues merge, add 6-8 times of weight parts water, decoct twice, first time 1.5-2 hour, second time 1 hour, merge decoction liquor, filter, filtrate is condensed into relative density 1.20-1.35(60 DEG C) clear paste;

(4) get the fine powder of step 1, with the clear paste in the thick paste of step 3, step 4, mixing, dry, pulverize into fine powder, then adds the clathrate in step 1, mix homogeneously, dry, loads No. 0 capsule, and every contains medicated powder 0.3g, obtains 1000.After ethane via epoxyethane sterilizing, place 7-10 days, subpackage, 30/bottle.

Treating both the principal and secondary aspects of a disease of the present invention, symptomatic treatment is strong, and curative effect is high, and has no side effect, and has no adverse reaction.

Set by the pathogenesis such as we are damp and hot for wind-fire, deficiency of YIN blood is dry, Flos Lonicerae, Periostracum Cicadae, Folium Perillae can clearing away heat and expelling wind be all monarch drug, and Cortex Phellodendri, Herba Portulacae all can heat-clearing and toxic substances removing dampness, Radix Angelicae Sinensis, Rhizoma Chuanxiong enrich blood invigorate blood circulation, promoting the circulation of QI to relieve pain, Talcum, the Radix Rehmanniae, Cortex Moutan, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra can removing heat from blood, can invigorate blood circulation again; Radix Scrophulariae, Radix Ophiopogonis, Herba Dendrobii all can YIN nourishing and the production of body fluid promoting, nourishing YIN and clearing away heat, and the merit of gathering altogether is ministerial drug; The merit of the expelling pathogenic factors from the exterior of Herba Ephedrae, the Radix Angelicae Dahuricae can parasite killing pain relieving; Radix Platycodonis is used for gas of enriching blood; Radix Rhodiolae benefiting QI for activating blood circulation; Radix Bupleuri dispersing the stagnated live-QI to relieve the stagnation of QI; Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.We can clearing away heat and expelling wind, removing heat from blood and promoting blood circulation, again can dispelling wind for relieving itching, heat-clearing and toxic substances removing.All medicine Cheng Fang, bring out the best in each other, play principle for the treatment of altogether.

Medication mechanism:

The traditional Chinese medical science is thought, cheilitis many because of pungent savoury too, raw in damp-heat in the spleen and stomach, attack by ailment said due to cold or exposure again, the damp and hot heresy of priming is followed through stifling lip; Or deficiency-weakness of spleen-QI, diseases caused by exogenous pathogenic factor are scorching, cause spleen channel blood dry, the smoked lip that burns send out.Deficiency of YIN blood is dry, lip loses supports, and spleen channel blood is dry to be caused.Or the liver failing to maintain the normal flow of QI, perverse and unreasonable manner violates stomach, stomach-QI being unable to descend normally.Exopathogenic factor Exposure to Sunlight, wind or sting caused by the bad habits such as lip.

The traditional Chinese medical science is particular about determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, the exfoliative inflammation of the lips distinguish a point deficiency and excess.Real be that wind-fire is damp and hot, and red lip is swollen itches and to burst bitterly and acute; Void is that deficiency of YIN blood is dry, red lip crack from dryness spilling water incrustation.Treatment by oral administration of medicines is by the loose heresy of Chinese medicinal formulae dispelling wind, clearing away heat-damp and promoting diuresis, cooling blood, expelling wind, nourishing YIN to relieve dryness.

In addition, similar with " exfoliative inflammation of the lips ", " exfoliative inflammation of lips " in TCM Document etc.As " " General Treatise on the Cause and Symptoms of Diseases volume 30 ": " spleen and stomach close the bright warp of foot sun, and also, it is through arising from nose for the arteries and veins of stomach, and ring is in lip, and its offshoot enters network in spleen, and taste have pathogenic wind-heat to take advantage of it, and swell in lip.”。" Yan's prescriptions for succouring sick ability to speak door ": " lip person, the institute of spleen is main ... lid domination of pathogenic wind may shake the body, and domination of cold is then taken off, domination of pathogenic dryness causing symptoms of dryness, and domination of heat then splits, and the stagnation of QI is raw skin ulcer then, and insufficiency of blood is then heavy and colourless.Control method, its spleen of Nei Zedangli, outward then when apply with medicine, effect person invariably.”。" Yizong Jinjian volume 65 ": " this disease is born in lower lip more, is formed through wind-fire condensation by the bright stomach of sun.Itch at the beginning, color is red to swell, and with the passing of time break flowing water, and pain is burned as fire, again like without skin, therefore wind to contain then lip Bu Shi Shun dynamic.”

Its etiology and pathogenesis is that wind-fire is damp and hot, outer criminal's lip.Stomach channel of foot-Yang-ming collar extension lip.Element is addicted to pungent savoury, raw in damp-heat in the spleen and stomach, feels ailment said due to cold or exposure again, the damp and hot upper steaming of priming, and knot lip of fighting forms, and deficiency of YIN blood is dry, and lip loses supports.Spleen associating with mouth, its China at lip, deficiency-weakness of spleen-QI, the heresy that diseases caused by exogenous pathogenic factor are scorching, or after epidemic febrile disease, impairment of YIN dryness-transformation, scorchingly follow through upper smoked sarolemma, in recent years, Chinese medicine have accumulated certain experiences in the treatment of Atopic cheilitis, and obtain comparatively satisfied clinical efficacy, allergic cheilitis should with spleen reinforcing stomach invigorating, and dispelling wind falls apart heresy, clearing away heat-damp and promoting diuresis, cooling blood, expelling wind, nourishing YIN to relieve dryness, nourishing liver, invigorating kidney, depressed liver-energy dispersing and QI regulating, dispelling wind for relieving itching is Therapeutic Principle.

Flos Lonicerae: sweet, cold.Return lung, the heart, stomach warp.Heat-clearing and toxic substances removing, dispelling wind and heat pathogens.For carbuncle furuncle, sore throat, erysipelas, toxic-heat and blood stasis, anemopyretic cold, epidemic febrile disease is generated heat.Flos Lonicerae is cold in nature, sweet in the mouth, enters lung, the heart, stomach warp, has heat-clearing and toxic substances removing, antiinflammatory, tonify deficiency treat effect of wind, cures mainly disease under distension, epidemic febrile disease heating, the diseases such as pyretic toxicity carbuncle and ulcer and tumor.The diseases such as it is dizzy for giddy, xerostomia is done yearningly, hyperhidrosis is unhappy, enteritis, bacillary dysentery, measles, pneumonia, encephalitis b, epidemic encephalitis, acute mastitis, septicemia, appendicitis, skin infection, carbuncle furuncle, erysipelas, parotitis, suppurative tonsillitis all have certain curative effect.Shennong's Herbal carries: " Flos Lonicerae sweet in the mouth cold in nature, has effect of heat-clearing and toxic substances removing, removing heat from bloodization silt, cure mainly affection due to external wind and heat, pestilence from the beginning of, skin infection furunculosis, red and swollen heat pain, passing stool with blood and pus " etc.Flos Lonicerae is discussed in detail and has the effect of " for a long time clothes make light of one's life by commiting suicide, life lengthening " in Compendium of Material Medica.The 1980s, health ministry has successively carried out chemical analysis to Flos Lonicerae, result shows: Flos Lonicerae contains the necessary trace element of multiple human body and chemical composition, simultaneously containing the multiple organized enzyme material favourable to human body, there is defying age, anti-canceration, the good effects of being healthy and strong of making light of one's life by commiting suicide.

Cortex Phellodendri: bitter, cold.Return kidney, urinary bladder channel.Heat clearing and damp drying, pathogenic fire purging removes steams, detoxification sore treatment.For damp-heat dysentery, jaundice dark coloured urine, leukorrhagia pudendal pruritus, the puckery pain of pyretic stranguria, beriberi flaccidity of feet with lamenness, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.Stir-baked CORTEX PHELLODENDRI with salt solution nourishing YIN to lower pathogenic fire.For hyperactivity of fire caused by deficiency of YIN, night sweat hectic fever due to YIN-deficiency." Japan hanako materia medica ": " feel at ease except labor, control hectic fever due to YIN-deficiency, wash liver, improving eyesight, many tear, xerostomia, heat in the heart, kill infantile malnutrition worm, control ascarid pained, scabies, processed with honey controls serious epistaxis, and hemorrhoidal hamorrhage rushes down blood, and rear point anxious heat swells and ache.Stagnation of pathogenic heat in " " herbal classic ": " main the five internal organs the intestines and stomach, jaundice, intestinal hemorrhoid; Stopping leak dysentery, woman's whitish metrorrhagia, acute vulva ulcer."

Periostracum Cicadae: sweet, cold.Return lung, Liver Channel.Loose wind heat extraction, sore-throat relieving, rash, improving acuity of vision and removing nebula, spasmolytic.For anemopyretic cold, pharyngalgia hoarseness, measles without adequate eruption, rubella pruritus, cataract, convulsion with spasms, tetanus.Amplification on Canon of Materia Medica: control blurred vision nebula.Decocting shell juice again, controlling children's, to go out skin ulcer rash unhappy." detailed outline ": control phlegm-accumulating vertigo, skin wind heat, varioliform exanthema is had an itch, tetanus and treatment toxic swelling tumor, and adult's aphonia, children's's lockjaw sky hangs, frightened night cry of crying, swelling of the vulva.

Folium Perillae: pungent, temperature.Return lung, spleen channel.Induce sweat cold expelling, relieving QI stagnancy in the stomach.For anemofrigid cold, cough vomiting and nausea, vomiting during pregnancy, fish Eriocheir sinensis is poisoning." Japan hanako materia medica ": " invigorating the spleen and replenishing QI.Control trusted subordinate's distension, only cramp caused by acute vomiting and diarrhea, whetting the appetite, and (controlling) all cold air, only beriberi." " detailed outline ": promoting the circulation of QI to alleviate the stagnation in middle-JIAO, expectorant profit lung, and blood, warming middle-JIAO, pain relieving, Dingchuan, antiabortive.

Herba Portulacae: acid, cold.Return liver, large intestine channel.Heat-clearing and toxic substances removing, cooling blood for hemostasis.For toxic-heat and blood stasis, carbuncle furuncle, eczema, erysipelas, snake bite and insect sting, has blood in stool, hemorrhoidal bleeding, metrostaxis.6. " Kaibao Bencao ": " cold removing heat, kills parasites, and the ， Po Disorder that quenches the thirst ties carbuncle skin ulcer for the blind white clouds of argument, sharp defecation.Burn again for ash, and vinegar dregs for many years, first moxibustion fourth swells.To seal it, namely root goes out. and raw strand juice of smashing takes, and when disliking thing under profit, removes tapeworm." Tang Materia Medica: " main all swollen fistula verruca, smash and wipe it; The main regurgitation of drink juice, Zhu Lin, incised wound blood flow, removing blood stasis addiction disease addiction, children's You Liang; Wash tight lip, pimples, horse antiperspirant with juice, penetrate being recovered of work poison painting."

Radix Angelicae Sinensis: sweet, acrid, warm.Return liver, the heart, spleen channel.Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, rheumatic arthralgia, injury from falling down, ulcer sores, dryness of the intestine constipation.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down." not Lu ": " warming middle-JIAO to relieve pain, fills in except in objective blood, middle puerperal tetanus, no sweating, arthralgia chiefly caused by damp pathogen, and attacked by pestiferous factors is courteous, cold caused by deficiency, mends five and hides, granulation promoting meat." " property of medicine opinion ": " preventing or arresting vomiting is inverse, asthenia cold and heat, broken stagnated blood, main woman's metrorrhagia, and lower the intestines and stomach is cold, mends various symptoms and signs of deficiency, and dysentery relieving is suffered from abdominal pain.Singly boil drink juice, control pyrexial malaria, main woman's lumbago with blood stasis, treat tooth pain unbearably painful.Suffer from people's cold caused by deficiency add and use it." Radix Angelicae Sinensis sweet in the mouth and weighing, therefore specially can enrich blood, its gas is light and pungent, therefore again can promoting the circulation of blood, and invigorating middle warmer has, and having benefit in row, is the key medicine in blood.Thus, it can be enriched blood, and can invigorate blood circulation again, both can stimulate the menstrual flow, again can be active.All menoxenias, dysmenorrhea, blood deficiency amenorrhea, shallow complexion, weak anemia, metrorrhagia, postnatal blood stasis, example, through the commonly encountered diseases of women such as (during menstrual onset, occurring that mouth and nose are bled), can use angelica for treating.Radix Angelicae Sinensis is that the most frequently used medicine in the traditional Chinese medical science is used for Baoshang, is best especially to Anemic patients.Body hemopoietic function be can also significantly promote, erythrocyte, leukocyte and content of hemoglobin raised.

Rhizoma Chuanxiong: pungent, temperature.Return liver, gallbladder, pericardium channel.Blood-activating and qi-promoting, wind-expelling pain-stopping.Pained for thoracic wall, the twinge of the breast side of body, tumbling and swelling, menoxenia, amenorrhea dysmenorrhea ， mass in the abdomen is suffered from abdominal pain, headache, rheumatic arthralgia." property of medicine opinion ": control waist foot weak, hemiplegia, main afterbirth does not go out, and controls cold type of pain in abdomen." Japan hanako materia medica ": control a wind cutting, all gas, all strains, all blood, mend five kinds of over strain, strengthening bone and muscle, adjusts many arteries and veins, and broken crux stagnated blood, supports fresh blood, put on flesh, serious epistaxis, spits blood and hematuria, hemorrhoid complicated by anal fistula, brain carbuncle carbuncle on the back, and scrofula wart is gone to live in the household of one's in-laws on getting married, skin ulcer scabies, and evacuation of pus repercussive blood.

The Radix Rehmanniae, sweet, cold.GUIXIN, liver, kidney channel.Clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting.Enter nutrient blood for heat, maculae caused by violent heat pathogen, hematemesis and epistaxis, consumption of YIN caused by febrile disease, crimson tongue excessive thirst, constipation is hindered in Tianjin, fever due to yin deficiency, and hectic fever due to YIN-deficiency consumptive fever, interior-heat is quenched one's thirst.Amplification on Canon of Materia Medica: removing heat from blood is enriched blood, tonification kidney water kidney-YIN being deficient.This medicine Great Cold, should consider with it, many clothes are probably hurted sb.'s feelings gastric qi.

" Yaoxing Fu ": sweet in the mouth, hardship, cold in nature, nontoxic.Sink also, the moon also.It is with having four: the heat in blood of cool heart-fire, purgation of spleen excess soil damp and hot, and the nosebleed only in nose is hot, except the dysphoria with smothery sensation of five hearts.

Radix Paeoniae Rubra: bitter, is slightly cold.Return Liver Channel.Clearing away heat and cooling blood, eliminating stasis to stop pain.Enter nutrient blood for heat, maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, mass in the abdomen is suffered from abdominal pain, injury from falling down, carbuncle skin infection." herbal classic ": " main apoplexy enters brain headache, arthralgia due to cold, clonic spasm of the muscle emergency, and gold wound, married woman's blood closes loss of fecundity." " not Lu ": ", on face, urticaria goes, order lacrimation, profuse nasal discharge and spittle except cold dynamic in brain, before we notice it as liquor-saturated, all cold gas, the hard pain of trusted subordinate, attacked by pestiferous factors, soldier is anxious to swell and ache, side of body wind pain, warming middle-JIAO endogenous cold." " Japan hanako materia medica ": " controls a wind cutting, all gas, all strains, all blood, and mend five kinds of over strain, strengthening bone and muscle, adjusts many arteries and veins, and broken Disorder ties stagnated blood, supports fresh blood, puts on flesh, serious epistaxis, spits blood and hematuria, hemorrhoid complicated by anal fistula, brain carbuncle carbuncle on the back, and scrofula wart is gone to live in the household of one's in-laws on getting married, skin ulcer scabies, and evacuation of pus repercussive blood."

Cortex Moutan: bitter, pungent, is slightly cold.GUIXIN, liver, kidney channel.Clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling.Enter nutrient blood for heat, maculae caused by violent heat pathogen, hematemesis and epistaxis, night fever abating at dawn, lossless hectic fever due to YIN-deficiency, amenorrhea dysmenorrhea, falls and flutters the pain of injury, carbuncle sore tumefacting virus." not Lu ": " except seasonal epidemic pathogens headache, exopathogenic heat five kinds of over strain, consumptive disease head lumbago, wind is kept silent, insane disease." " property of medicine opinion ": " controls cold air, and loose all pains, control woman's passages through which vital energy circulates obstructed, blood drop pain in the lumbar region." " Japan hanako materia medica ": " except pathogen, happy color, clearance natural fibre line of meat blood vessels, evacuation of pus, logical menstruation, disappear and flutter damage blood stasis, reuniting the fractured tendons and bones, except migratory arthralgia, fall tire lower eyelid, puerperal all cold and hot vim and vigour.

Radix Scrophulariae: sweet, bitter, salty, is slightly cold.Return lung, stomach, kidney channel.Clearing away heat and cooling blood, YIN nourishing by fire, detoxicating and resolving stagnation of pathogens.For calentura nutrient blood, maculae caused by violent heat pathogen, consumption of YIN caused by febrile disease, crimson tongue excessive thirst, constipation is hindered in Tianjin, hectic fever due to YIN-deficiency chronic cough, conjunctival congestion, pharyngalgia, diphtheria, scrofula, carbuncle sore tumefacting virus." medicineization justice ": " wear people to call kidney this is cold, void is then hot.As consumption essence of indulging in sensual pleasures, Kidney-Yin loss, causes hyperactivity of deficient fire, presses down fire with Radix Scrophulariae YIN nourishing.Regretful Nang under all headaches, pyretic toxicity, tinnitus, pharyngalgia, acute throat trouble, scrofula, typhoid fever YANG toxin syndrome, the heart, the fire that all unrooted swims is trouble, and this has goes up clearly clear purgation merit.All controlling is suffered from a deficiency of the kidney, and has greatly respectively, kidney then cold and wet through void, suitable temperature compensation it; The deficiency of five ZANG-organs of kidney then heat and dry, should cool benefit it; Solely this cool profit nourishing kidney, merit victory is known, cypress, specially for kidney monarch drug.

Radix Ophiopogonis: sweet, micro-hardship, is slightly cold.GUIXIN, lung, stomach warp.YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.For dryness of the lung dry cough.Deficiency of YIN consumptive disease is coughed, sore throat pharyngalgia, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, vexed insomnia, dryness of the intestine constipation.

Herba Dendrobii: sweet, is slightly cold.Return stomach, kidney channel.Reinforcing stomach reg fluid, nourishing YIN and clearing away heat.For calentura Tianjin wound, xerostomia excessive thirst, deficiency of stomach-Yin, lack of appetite is in vomitting, and deficiency-heat after being ill, does not move back, and YIN-fire void is prosperous, hectic fever due to YIN-deficiency consumptive fever, poor vision, muscles and bones Microsoft.Current research, effect of Herba Dendrobii: YIN nourishing tonify deficiency.Modern medicine and traditional Chinese medical science pharmacological research show, Herba Dendrobii has obvious effect in raising human body immunity, defying age, Tumor suppression, tonifying five ZANG-organs asthenia etc.The title having " help Herba mesonae chinensis " among the people.Be commonly called as medicine gold, cold in nature, sweet in the mouth is light, micro-salty.Be born on cliff, stem is grown thickly.Health care: nourishing YIN and moistening the lung, stomach reinforcing the kidney invigorating, builds brain improving eyesight, pathogenic fire reducing good medicine, and tool promoting the production of body fluid to quench thirst, tonifying five ZANG-organs asthenia, clearing away lung-heat to relieve cough, anti-flu, effect of resisting fatigue.

Herba Ephedrae: pungent, micro-hardship, temperature.Return lung, urinary bladder channel.Diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema.For anemofrigid cold, uncomfortable in chestly to breath with cough, edema due to wind pathogen edema.Herba ephedrae nourishing the lung to arrest cough.Be used for exterior syndrome to separate, asthma and cough." herbal classic ": " main apoplexy, cold headache, pyrexial malaria.Deliver perspiration, uncharm steam, only cough with dyspnea, and except cold and heat, broken disease heavily fortified point gathers." " not Lu ": " main the five internal organs pathogen emergency, wind hypochondriac pain, disease more than word breast.Only good saliva, logical space between skin and muscles, expelling pathogenic factors from muscles; Let out evil gas, disappear red black speck poison."

" Japan hanako materia medica ": " logical small intestinal, evacuation of pus.Control furuncle, pain relieving, logical menstruation."

Talcum: sweet, light, cold.Return bladder, lung, stomach warp.Inducing diuresis for treating stranguria syndrome, clearing away summer-heat.External damp eliminating sore.For pyretic stranguria, stranguria caused by urinary stone, urinates hot puckery pain, heat-damp in summer excessive thirst, damp and hot watery diarrhea; External treatment eczema, eczema, miliaria." Amplification on Materia Medica addendum ": " real large intestine, relieving dyspepsia poison, row is stagnant, by blood coagulation, separates yearningly dry, tonifying the spleen and stomach, falls the key medicine of heart-fire for dampness, diversion channel." " book on Chinese herbal medicine is new again ": " clearing away fire and eliminating phlegm, dampness removing is relieved summer heat, and restores menstrual flow and invigorates blood circulation, and antidiarrheal dysentery is vomitted, consumer edema fire-toxin."

Radix Platycodonis: bitter, pungent is flat.Return lung meridian.Lung qi dispersing, sore-throat relieving, eliminates the phlegm, evacuation of pus.For cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia hoarseness, lung abscess vomiting pus." Japan hanako materia medica ": " mend five kinds of over strain, foster the spirit of nobility, evil removing wards off temperature, tonify deficiency expectorant for all gas lower, only cramp caused by acute vomiting and diarrhea, trusted subordinate's distending pain, broken lump in the abdomen, and evacuation of pus of nourishing blood, mends internal hemorrhage due to trauma and sore throat." " not Lu ": " sharp the five internal organs the intestines and stomach, gas of enriching blood, except cold and heat, migratory arthralgia, warming middle-JIAO rapid digestion of food, treats laryngopharynx pain."

Radix Rhodiolae: sweet, bitter is flat.Return lung, heart channel.Benefiting QI for activating blood circulation, promotes blood circulation and relievings asthma.For blood stasis due to qi deficiency, obstruction of qi in the chest and cardialgia, apoplectic hemiplegia, asthenia is panted." Jingzhubencao " speech " Radix Rhodiolae is invigorated blood circulation, and lung heat clearing, cough-relieving are brought down a fever, pain relieving, be used for the treatment of pneumonia, tracheitis, physical weakness, malaise, uncomfortable in chest, be difficult to breathe freely, lip and the palm of the hand blue "." modern practical book on Chinese herbal medicine " says that its effect has seven, namely " one, central inhibitory action.Two, antifatigue effect.Three, cardiotonic.Four, antiinflammatory action.Five, blood glucose rising effect is suppressed.Six, Hardy dwarfing.Seven, resisting microwave radiation effect ".Modern medicine study proves, containing 35 kinds of trace element in Radix Rhodiolae, 18 seed amino acids, vitamin A. D. E and activity of fighting against senium superoxides, its nutritional labeling is complete and compatibility reasonable, is rare in current found plant.In pharmacology, now prove that Radix Rhodiolae has central excitation effect and " adaptation former state " effect, people can have been eliminated and " tire out ", strengthened memory and attention, made the heart of quickening contraction frequency recover normal.

The pharmacy worker of recent domestic conducts in-depth research Radix Rhodiolae, proposes the effect that Radix Rhodiolae has " the adaptation former state " of similar Radix Ginseng " strengthening the body resistance ", and is also better than Radix Ginseng in some aspects, do not have the deficiency that Radix Ginseng excitation is excessively strong.Effective ingredient contained by Radix Rhodiolae has heart tonifying calmness, regulates the effect of metabolism, nervous system regulation and hormonal system two-ways regulation blood glucose, blood pressure, be used for the treatment of cerebrovascular disease, the diseases such as senile myocardial failure, diabetes, hypotension, also for body is empty, old after being ill, nerve is weak.

Radix Bupleuri: bitter, is slightly cold.Return liver, gallbladder, lung meridian.Evacuation is brought down a fever, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy.For cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia; Uterine prolapse, proctoptosis." Japan hanako materia medica ": " mend five kinds of strain and seven kinds of impairment, relieving restlessness spasmolytic, physical strength profiting, expectorant antitussive, profit cardiopulmonary, add essence and mend marrow, sky capable temperature disease is fanatical absolutely weary, breast side of body fullness caused by stagnant QI, forgetful." " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " typhoid fever relieving the exterior syndrome by diaphoresis key medicine, moves back the contact of the six channels pathogenic heat, numbness flaccidity, and except liver man pathogenic heat, consumptive disease heat, the gas of the inverse knot of row Liver Channel, only left flank irritability pain, controls married woman's heat in blood and burn warp, can adjust menstruation.The tender stamen of " " diaphoresis, controls deficiency-heat, regulating menstruation root."

The Radix Angelicae Dahuricae: acrid in the mouth; Warm in nature.Attach to the lung and stomach meridians.Effect: expelling cold and relieving exterior syndrome, dispeiling pathogenic wind and removing dampness, detumescence and apocenosis, pain relieving.For exterior syndrome due to wind-cold, headache, toothache, carbuncle skin ulcer swells and ache, cold-damp leukorrhagia." Japan hanako materia medica ": " control conjunctival congestion bulbar conjunctiva polyp, and tire patching leaks landing, broken stagnated blood, mend fresh blood, acute mastitis, carbuncle on the back, scrofula, hemorrhoidal hamorrhage, hemorrhoid complicated by anal fistula, evacuation of pus, desolation, scabies, pain relieving granulation promoting, goes face Shao-defect scar." " detailed outline ": " controls nasal sinusitis, epistaxis, toothache, supraorbital bone pain, large intestine constipation due to pathogenic wind, bleeding urine, and married woman's blood dizziness due to wind pathogen is transported, and regurgitation of food from the stomach tells food; Solution arsenic poison, snakebite, cutter arrow incised wound.

Radix Salviae Miltiorrhizae: bitter in the mouth; Cold nature.Enter the heart, Liver Channel.Effect: blood circulation promoting and blood stasis dispelling, removing heat from blood eliminating carbuncle, nourishing blood to tranquillize the mind.For menoxenia, trusted subordinate pain ， lumps in the chest and abdomen, beriberoid pyretic arthralgia, skin infection swells and ache, and agitation is insomnia, cardiopalmus, insomnia." Japan hanako materia medica ": " sedate of reposing, tonneau GUAN-pulse.Control cold and hot labor, arthralgia, extremity are unsuccessful; Evacuation of pus pain relieving, granulation promoting is put on flesh; Broken stagnated blood, mends new hemopoietic; Peaceful tire, fall stillborn fetus; Under hemostasis metrorrhagia and leukorrhagia, adjust married woman's passages through which vital energy circulates irregular, blood evil thought is tired of; Malignant boil scabies, wart is gone to live in the household of one's in-laws on getting married toxic swelling, erysipelas; Headache, acute conjunctivitis, hot temperature is mad vexed." " choosing of Yunnan Chinese herbal medicine ": " promoting blood circulation to remove blood stasis, sedation-analgesia.Control menoxenia, dysmenorrhea, rheumatic arthralgia, metrorrhagia, spit blood, mastitis, carbuncle."

Radix Glycyrrhizae: sweet, flat.GUIXIN, lung, spleen, stomach warp.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.

Detailed description of the invention

Below, in conjunction with example, substantive distinguishing features of the present invention and advantage are further described, but the present invention is not limited to listed embodiment.

Embodiment 1

Treat a Chinese medicine composition for allergic cheilitis, comprise following component by weight: Flos Lonicerae 8 parts, Periostracum Cicadae 8 parts, Folium Perillae 8 parts, Herba Portulacae 5 parts, Radix Angelicae Sinensis 5 parts, Rhizoma Chuanxiong 5 parts, Radix Rehmanniae 3-5 part, Radix Paeoniae Rubra 5 parts, Cortex Moutan 5 parts, Radix Scrophulariae 5 parts, Radix Ophiopogonis 5 parts, Herba Dendrobii 5 parts, 5 parts, Herba Ephedrae, Cortex Phellodendri 5 parts, 2 parts, Talcum, the Radix Angelicae Dahuricae 5 parts, Radix Platycodonis 5 parts, Radix Salviae Miltiorrhizae 5 parts, Radix Rhodiolae 8 parts, Radix Bupleuri 5 parts, 2 parts, Radix Glycyrrhizae.

(3) get Cortex Phellodendri, Periostracum Cicadae, Folium Perillae, Cortex Moutan, Herba Dendrobii, Herba Ephedrae, Talcum, the Radix Angelicae Dahuricae, Radix Bupleuri, Radix Glycyrrhizae and step 1, step 2 medicinal residues merge, add 8 times of weight parts waters, decoct twice, 2 hours first times, second time 1 hour, merge decoction liquor, filter, filtrate is condensed into relative density 1.20-1.35(60 DEG C) clear paste;

Usage and dosage: each 4-6 grain, every day three times.Anemia of pregnant woman is forbidden.

Embodiment 2

Treat a Chinese medicine composition for allergic cheilitis, comprise following component by weight: Flos Lonicerae 5 parts, Periostracum Cicadae 5 parts, Folium Perillae 5 parts, Herba Portulacae 3 parts, Radix Angelicae Sinensis 3 parts, Rhizoma Chuanxiong 3 parts, Radix Rehmanniae 3-5 part, Radix Paeoniae Rubra 3 parts, Cortex Moutan 3 parts, Radix Scrophulariae 3 parts, Radix Ophiopogonis 3 parts, Herba Dendrobii 3 parts, 3 parts, Herba Ephedrae, Cortex Phellodendri 3 parts, 1 part, Talcum, the Radix Angelicae Dahuricae 3 parts, Radix Platycodonis 3 parts, Radix Salviae Miltiorrhizae 3 parts, Radix Rhodiolae 5 parts, Radix Bupleuri 3 parts, 1 part, Radix Glycyrrhizae.

(3) get Cortex Phellodendri, Periostracum Cicadae, Folium Perillae, Cortex Moutan, Herba Dendrobii, Herba Ephedrae, Talcum, the Radix Angelicae Dahuricae, Radix Bupleuri, Radix Glycyrrhizae and step 1, step 2 medicinal residues merge, add 6 times of weight parts waters, decoct twice, 1.5 hours first times, second time 1 hour, merge decoction liquor, filter, filtrate is condensed into relative density 1.20-1.35(60 DEG C) clear paste;

From over 2006, adopt this preparation for treating of Empirical formula allergic cheilitis of the court, achieve good clinical effectiveness.Select complete data treatment group 100 example to carry out Clinical efficacy comparison with matched group 100 example herein, achieve satisfied effect, be now reported as follows:

Clinical data

All cases all meets " diagnostic criteria of TCM Dermatology disease " that State Administration of Traditional Chinese Medicine formulates.100 routine allergic cheilitis patients, man 64 example, female 36 example, 6 ~ 45 years old age, average 31.8 years old, the course of disease 15 days ~ 5 years, average 1 ~ 1.5 year.Clinical manifestation is just decortication in various degree, pruritus, redness, serious causes vesicle, wastes rotten, sepage, incrustation etc.Syndrome Differentiation of Traditional Chinese Medicine, for wind-fire is damp and hot, outer criminal's lip type, disease is seen: decortication, pruritus, redness, serious causes vesicle, wastes rotten, sepage, incrustation.Matched group 100 example, at the age, sex, symptom, the aspects such as sign, without significant difference, have comparability (P > 0.05) with treatment group (100 example).

2. Therapeutic Method

This preparation for the treatment of group, square medicine composition: Flos Lonicerae, Periostracum Cicadae, Folium Perillae, Herba Portulacae, Radix Bupleuri, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Rehmanniae, Radix Paeoniae Rubra, Cortex Moutan, Radix Scrophulariae, Radix Ophiopogonis, Herba Dendrobii, Herba Ephedrae, Cortex Phellodendri, Talcum, the Radix Angelicae Dahuricae, Radix Platycodonis, Radix Salviae Miltiorrhizae, Radix Rhodiolae, Radix Glycyrrhizae.We make requirement in strict accordance with " Chinese Pharmacopoeia " 95 editions pills and make capsule, oral, every day 2-3 time, each 4-6 grain, warm water delivery service.Matched group cetirizine vitaminize B2, oral, cetirizine, every day 1 time, each a slice; Vitamin B2,5 ~ 10mg on the one, warm water delivery service.

3. criterion of therapeutical effect and result

Main detection decortication, pruritus, redness, serious cause vesicle, waste rotten, sepage, the cardinal symptom such as incrustation, by light, in, score as parameters for observation on effect heavily respectively.1 course for the treatment of is observed patients clinical performance in two groups of medications again, and carries out training inspection, according in " People's Republic of China's traditional Chinese medical science industry standard ", evaluates about TCM Dermatology disease criterion of therapeutical effect, according to its integration, be divided into effective, take a turn for the better, invalid 3 kinds.Treatment group 100 example, effective 82 examples (82 ﹪), 14 examples that take a turn for the better (14 ﹪), invalid 4 examples (4 ﹪), total effective rate is 96 ﹪.Matched group 100 example, effective 58 examples (58 ﹪), 15 examples that take a turn for the better (15 ﹪), invalid 27 examples (27 ﹪), total effective rate is 73 ﹪.Compare for two groups, total effective rate has significant difference (P < 0.01), over the course for the treatment of, finds no toxic and side effects, and anaphylaxis.

The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.

Claims

1. treat the Chinese medicine composition of allergic cheilitis for one kind, it is characterized in that, comprise following component by weight: Flos Lonicerae 5-8 part, Periostracum Cicadae 5-8 part, Folium Perillae 5-8 part, Herba Portulacae 3-5 part, Radix Angelicae Sinensis 3-5 part, Rhizoma Chuanxiong 3-5 part, Radix Rehmanniae 3-5 part, Radix Paeoniae Rubra 3-5 part, Cortex Moutan 3-5 part, Radix Scrophulariae 3-5 part, Radix Ophiopogonis 3-5 part, Herba Dendrobii 3-5 part, Herba Ephedrae 3-5 part, Cortex Phellodendri 3-5 part, Talcum 1-2 part, Radix Angelicae Dahuricae 3-5 part, Radix Platycodonis 3-5 part, Radix Salviae Miltiorrhizae 3-5 part, Radix Rhodiolae 5-8 part, Radix Bupleuri 3-5 part, Radix Glycyrrhizae 1-2 part.

2. treat a preparation method for allergic cheilitis Chinese medicine composition described in claim 1, it is characterized in that, comprise the following steps:

(4) get the fine powder of step 1, with the clear paste in the thick paste of step 3, step 4, mixing, dry, pulverize into fine powder, then adds the clathrate in step 1, mix homogeneously, dry, loads No. 0 capsule, and every contains medicated powder 0.3g, obtains 1000;

After ethane via epoxyethane sterilizing, place 7-10 days, subpackage, 30/bottle.