CN104147441A

CN104147441A - Traditional Chinese medicine for treating yang-deficiency water-flooding type chronic cardiac insufficiency and preparation method thereof

Info

Publication number: CN104147441A
Application number: CN201410415325.6A
Authority: CN
Inventors: 朱靖; 孔春妍; 刘芳; 王健
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-08-22
Filing date: 2014-08-22
Publication date: 2014-11-19

Abstract

The invention discloses a traditional Chinese medicine for treating yang-deficiency water-flooding type chronic cardiac insufficiency and a preparation method thereof, wherein the traditional Chinese medicine comprises the following raw medicinal materials: poria cocos, coix seed, corn stigma, semen hoveniae, dried orange peel, radix aucklandiae, agilawood, fructus citrus sarcodactylis, fructus citri, allium macrostemon, betelnut peel, sword bean, semen raphani, paederia scandens, semen brassicae, inula flower, cynanchum glaucescens, platycodon root, fructus perillae, folium rhododendri daurici, radix physochlainae, flos farfarae, cortex mori, radix codonopsis, Chinese yam, radix acanthopanacis semticosi, human placenta, cynomorium songaricum, radix polygonati officinalis, cerastiumrvense L. and gorse. The traditional Chinese medicine has the beneficial effects that the traditional Chinese medicine has the efficacies of warming yang to promote diuresis, and mainly treats the yang-deficiency water-flooding type chronic cardiac insufficiency; with utilization of a traditional Chinese medicine theory and through adjustment of the whole blood circulation, the traditional Chinese medicine improves qi and blood of body circulation and pulmonary circulation, treats based on syndrome differentiation, is capable of adjusting arrhythmia, controlling blood pressure, improving body water and electrolyte disorder, enhancing a heart blood-pumping function, improving a respiratory function and the like, has multiple target spots, allows drug efficacy to directly reach nidi, is remarkable in curative effect, and is safe and effective.

Description

A kind of Chinese medicine and preparation method for the treatment of type of water overflowing caused by insuffi ciency of YANG chronic cardiac insufficiency

Technical field

The present invention relates to pharmaceutical technology, particularly a kind of Chinese medicine and preparation method for the treatment of type of water overflowing caused by insuffi ciency of YANG chronic cardiac insufficiency.

Background technology

Cardiac insufficiency is called again " heart failure ", is the syndrome that cardiac pumping function is incomplete.Refer to that, in the situation that venous return is suitable, heart can not be discharged enough blood and meet the needs of body tissue's metabolism.Human body can mobilize compensatory mechanism to maintain the stable of systemic circulation in early days, as make myocardium hypertrophy, improve preload, reflex excitation sympathetic nerve, even activate renin angiotensin aldosterone system and arginine vasopressin system, cardiac function is now in the complete compensatory stage.But with PD, sympathetic tone and renin angiotensin aldosterone system hyperactivity, make water, sodium retention in body, the forward and backward overload of heart, and further damage heart systolic and diastolic function, human bloodstream state is absorbed in vicious cycle, cardiac pumping function loses compensatory, cardiac output more becomes to reducing, and venous blood is obviously retarded by silt and enters congestive heart failure, i.e. chronic heart failure.

Briefly, cardiac insufficiency is exactly because cardiac function is abnormal, can not meet a series of clinical symptoms that the each histoorgan of health causes for the demand of cardiac pumping.For patient, cardiac insufficiency is a heavy topic.Because it is a kind of syndrome, tired, breathe hard, cardiopalmus, lose weight, atrophy of flaccid muscles, all day bed.Be clinical common syndrome, its sickness rate is higher, and mortality rate is also high, and chronic cardiac insufficiency Basic disease cause is various chronic myocardium disease damages and long-term ventricle overload.

The cause of disease

Cause that in China chronic cardiac insufficiency comprises: constitutional and Secondary cases two classes, the cause of disease comprises: unknown cause and valve disease are main, is secondly hypertension and coronary atherosclerotic heart disease (chronic cardiac insufficiency).Its inducement is mainly: infection, arrhythmia, Electrolyte imbalance, overtired, stress is overweight, amblent air temperature sharply changes and gestation, the concurrent other diseases etc. of giving a birth.

Clinically, chronic cardiac insufficiency is the most common with left heart insufficiency, its major effect patient's pulmonary circulation.Can show as that dyspnea, cough, expectoration, spitting of blood, nocturia increase, fatigue and weak.

More there is the aging and disease of other internal organs in old people, therefore can disturb the clinical manifestation of some cardiac insufficiencys.Even if many old peoples have cardiac insufficiency to exist, when movable, do not feel obviously out of breath, and show as extremely tired and cough, often there is uncommon dripping sweat.Left heart insufficiency is difficult for and the difference such as chronic obstructive pulmonary disease and pulmonary infection.

Cardiac insufficiency has multiple criteria for classification, can be divided into acute cardiac insufficiency and chronic cardiac insufficiency by its development process; Can be divided into left heart insufficiency, right heart insufficiency and total cardiac insufficiency by the position of outbreak exhausts; Can be divided into not full property cardiac insufficiency etc. of systolic dysfunction cardiac insufficiency and diastolic function by the ultimate principle occurring.

The cardiac insufficiency traditional Chinese medical science is divided following several:

1, YIN-deficiency of both the heart and lung type: cardiopalmus, breathe hard, lassitude of the limbs and weakness, moving aggravation, Mental fatigue cough with asthma, pale complexion, there is indentation on light red tongue or limit, deep-thready pulse or imaginary number.

2, deficiency of qi and yin type: cardiopalmus, breathe hard, weak, sweating while acting, spontaneous perspiration or night sweat, dizzy vexed, xerostomia, face cheekbone is dark red, red tongue few tongue, thready and rapid pulse without strength or knot generation.

3, deficiency of heart-YANG and kidney-YANG type: cardiopalmus, shortness of breath and fatigue, moving asthma, coldness of the body cold extremities, oliguria edema, abdominal distention loose stool, face cheekbone is dark red, the few tongue of red tongue, thready pulse is said unable or knot generation.

4, Qi deficiency blood stasis type: shortness of breath and palpitation, the breast side of body is had a pain, and cervical region blue veins exposes, the lower mass in the abdomen of the side of body, edema of lower limbs, complexion is steel gray, bluish lip gentian violet, purplish tongue or have petechia, ecchymosis, hesitant pulse or knot generation.

5, type of water overflowing caused by insuffi ciency of YANG: shortness of breath and palpitation, maybe must not put down sleepingly, cough up and tell frothy sputum, face limb edema, aversion to cold and cold limbs, irritated perspiration, face amount is greyish white, cyanotic lips, oliguria abdominal distention, or companion's hydrothorax, ascites, tongue is dim or dark red, white and slippery fur, short or knot generation of thready pulse.

6, phlegm retention resistance pulmonary type: cardiopalmus is out of breath, coughing and wheezing, can not put down sleepingly, coughs up the yellow thickness of white expectorant or expectorant, and breast gastral cavity spleen is vexed, has a dizzy spell, oliguria edema, or companion's rale, or it is thirsty to generate heat, white and greasy fur or yellow greasy, stringy and rolling pulse or sliding number.

Western medical treatment chronic cardiac insufficiency, the course for the treatment of is longer, and untoward reaction is more, and drug withdrawal suddenly can produce withdrawal reaction severe patient can threat to life.

But Chinese medicine chronic cardiac insufficiency possesses unique advantage and feature, can make up the deficiency of doctor trained in Western medicine.Chinese medicine utilizes Traditional Chinese medical theory, and great attention to whole is seen, by adjusting whole blood circulation, improve body circulation and pulmonary circulation QI and blood, carry out determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, capable of regulating arrhythmia, control blood pressure, improve Electrolyte imbalance in body, strengthen cardiac pumping function, improve respiratory function etc., many target spots, the drug effect focus of going directly, evident in efficacy, safe and effective, convenient drug administration, patient is easy to accept, and can obviously improve patient's quality of life.

Summary of the invention

The technical problem to be solved in the present invention is to provide a kind of effect with warming YANG to promote diuresis, cures mainly the Chinese medicine of type of water overflowing caused by insuffi ciency of YANG chronic cardiac insufficiency.The present invention utilizes Traditional Chinese medical theory, and great attention to whole is seen, by adjusting whole blood circulation, improve body circulation and pulmonary circulation QI and blood, carry out determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, capable of regulating arrhythmia, control blood pressure, improve Electrolyte imbalance in body, strengthen cardiac pumping function, improve respiratory function etc., many target spots, the drug effect focus of going directly, evident in efficacy, safe and effective, convenient drug administration, patient is easy to accept, and can obviously improve patient's quality of life.

In order to realize foregoing invention object, the invention provides a kind of Chinese medicine for the treatment of type of water overflowing caused by insuffi ciency of YANG chronic cardiac insufficiency, comprise following raw medicinal material: Poria, Semen Coicis, Stigma Maydis, Semen Hoveniae (Fructus Hoveniae), Pericarpium Citri Reticulatae, the Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Citri Sarcodactylis, Fructus Citri, Bulbus Allii Macrostemonis, Pericarpium Arecae, Semen Canavaliae, Semen Raphani, fevervine, Semen Sinapis Albae, Flos Inulae, Rhizoma Cynanchi Stauntonii, Radix Platycodonis, Fructus Perillae, Folium Rhododendri Daurici, Radix Physochlainae, Flos Farfarae, Cortex Mori, Radix Codonopsis, Rhizoma Dioscoreae, Radix Et Caulis Acanthopanacis Senticosi, Placenta Hominis, Herba Cynomorii, Rhizoma Polygonati Odorati, field grasswort and Flos Caraganae Sinicae.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Poria 21-34 part, Semen Coicis 19-35 part, Stigma Maydis 24-36 part, Semen Hoveniae (Fructus Hoveniae) 13-28 part, Pericarpium Citri Reticulatae 15-31 part, Radix Aucklandiae 17-34 part, Lignum Aquilariae Resinatum 8-20 part, Fructus Citri Sarcodactylis 19-36 part, Fructus Citri 23-36 part, Bulbus Allii Macrostemonis 16-27 part, Pericarpium Arecae 26-38 part, Semen Canavaliae 11-27 part, Semen Raphani 7-19 part, fevervine 13-25 part, Semen Sinapis Albae 19-32 part, Flos Inulae 7-11 part, Rhizoma Cynanchi Stauntonii 22-36 part, Radix Platycodonis 18-31 part, Fructus Perillae 13-30 part, Folium Rhododendri Daurici 6-14 part, Radix Physochlainae 5-12 part, Flos Farfarae 10-24 part, Cortex Mori 11-26 part, Radix Codonopsis 14-30 part, Rhizoma Dioscoreae 15-31 part, Radix Et Caulis Acanthopanacis Senticosi 22-37 part, Placenta Hominis 5-13 part, Herba Cynomorii 7-19 part, Rhizoma Polygonati Odorati 14-28 part, field grasswort 12-28 part and Flos Caraganae Sinicae 4-10 part.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Poria 21-30 part, Semen Coicis 20-33 part, Stigma Maydis 26-34 part, Semen Hoveniae (Fructus Hoveniae) 15-25 part, Pericarpium Citri Reticulatae 17-29 part, Radix Aucklandiae 19-31 part, Lignum Aquilariae Resinatum 8-17 part, Fructus Citri Sarcodactylis 19-33 part, Fructus Citri 25-32 part, Bulbus Allii Macrostemonis 18-25 part, Pericarpium Arecae 29-38 part, Semen Canavaliae 12-24 part, Semen Raphani 8-17 part, fevervine 15-23 part, Semen Sinapis Albae 21-30 part, Flos Inulae 7-10 part, Rhizoma Cynanchi Stauntonii 24-33 part, Radix Platycodonis 19-29 part, Fructus Perillae 15-28 part, Folium Rhododendri Daurici 7-13 part, Radix Physochlainae 5-11 part, Flos Farfarae 12-21 part, Cortex Mori 13-21 part, Radix Codonopsis 14-26 part, Rhizoma Dioscoreae 15-29 part, Radix Et Caulis Acanthopanacis Senticosi 25-35 part, Placenta Hominis 6-11 part, Herba Cynomorii 7-14 part, Rhizoma Polygonati Odorati 16-26 part, field grasswort 14-25 part and Flos Caraganae Sinicae 5-9 part.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is: 30 parts, Poria, 27 parts of Semen Coiciss, 34 parts of Stigma Maydis, 25 parts of Semen Hoveniae (Fructus Hoveniae)s, 17 parts of Pericarpium Citri Reticulataes, 28 parts of the Radix Aucklandiae, 8 parts of Lignum Aquilariae Resinatum, 19 parts of Fructus Citri Sarcodactylis, 32 parts of Fructus Citris, 22 parts of Bulbus Allii Macrostemonis, 38 parts of Pericarpium Arecae, 17 parts of Semen Canavaliaes, 8 parts of Semen Raphanis, 23 parts of fevervines, 21 parts of Semen Sinapis Albaes, 7 parts of Flos Inulae, 24 parts of Rhizoma Cynanchi Stauntoniis, 29 parts of Radix Platycodoniss, 16 parts of Fructus Perillaes, 7 parts of Folium Rhododendri Daurici, 5 parts of Radix Physochlainae, 14 parts of Flos Farfaraees, 21 parts of Cortex Mori, 26 parts of Radix Codonopsis, 22 parts of Rhizoma Dioscoreaes, 35 parts of Radix Et Caulis Acanthopanacis Senticosis, 9 parts of Placenta Hominiss, 14 parts of Herba Cynomoriis, 21 parts of Rhizoma Polygonati Odorati, 5 parts of 14 parts of field grassworts and Flos Caraganae Sinicaes.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is: 21 parts, Poria, 20 parts of Semen Coiciss, 26 parts of Stigma Maydis, 19 parts of Semen Hoveniae (Fructus Hoveniae)s, 29 parts of Pericarpium Citri Reticulataes, 31 parts of the Radix Aucklandiae, 17 parts of Lignum Aquilariae Resinatum, 33 parts of Fructus Citri Sarcodactylis, 25 parts of Fructus Citris, 25 parts of Bulbus Allii Macrostemonis, 29 parts of Pericarpium Arecae, 24 parts of Semen Canavaliaes, 17 parts of Semen Raphanis, 19 parts of fevervines, 30 parts of Semen Sinapis Albaes, 10 parts of Flos Inulae, 33 parts of Rhizoma Cynanchi Stauntoniis, 19 parts of Radix Platycodoniss, 15 parts of Fructus Perillaes, 13 parts of Folium Rhododendri Daurici, 11 parts of Radix Physochlainae, 21 parts of Flos Farfaraees, 13 parts of Cortex Mori, 14 parts of Radix Codonopsis, 15 parts of Rhizoma Dioscoreaes, 25 parts of Radix Et Caulis Acanthopanacis Senticosis, 11 parts of Placenta Hominiss, 7 parts of Herba Cynomoriis, 26 parts of Rhizoma Polygonati Odorati, 6 parts of 25 parts of field grassworts and Flos Caraganae Sinicaes.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is: 26 parts, Poria, 33 parts of Semen Coiciss, 28 parts of Stigma Maydis, 15 parts of Semen Hoveniae (Fructus Hoveniae)s, 22 parts of Pericarpium Citri Reticulataes, 19 parts of the Radix Aucklandiae, 10 parts of Lignum Aquilariae Resinatum, 30 parts of Fructus Citri Sarcodactylis, 26 parts of Fructus Citris, 18 parts of Bulbus Allii Macrostemonis, 37 parts of Pericarpium Arecae, 12 parts of Semen Canavaliaes, 10 parts of Semen Raphanis, 15 parts of fevervines, 26 parts of Semen Sinapis Albaes, 9 parts of Flos Inulae, 26 parts of Rhizoma Cynanchi Stauntoniis, 23 parts of Radix Platycodoniss, 28 parts of Fructus Perillaes, 10 parts of Folium Rhododendri Daurici, 6 parts of Radix Physochlainae, 12 parts of Flos Farfaraees, 15 parts of Cortex Mori, 18 parts of Radix Codonopsis, 29 parts of Rhizoma Dioscoreaes, 30 parts of Radix Et Caulis Acanthopanacis Senticosis, 6 parts of Placenta Hominiss, 11 parts of Herba Cynomoriis, 16 parts of Rhizoma Polygonati Odorati, 9 parts of 18 parts of field grassworts and Flos Caraganae Sinicaes.

When the dosage form of described Chinese medicine is honey refining pill, its preparation method comprises the following steps:

Step 1: first Poria, Semen Coicis, Stigma Maydis, Semen Hoveniae (Fructus Hoveniae), Pericarpium Citri Reticulatae and the Radix Aucklandiae are mixed in described ratio, distillation crystallization obtains powder;

Step 2: get again surplus stock medical material and mix in described ratio, add 83-94% soak with ethanol 1-2 hour, the heating extraction 2 times doubly measured with respect to mixture 2-6, each 1-1.5 hour, merge extractive liquid,, 124-150 order filter, be the ultrafiltration post ultrafiltration of 4400-98000 again through the molecular weight that dams, the extractum that when ultrafiltrate is evaporated to 87 DEG C, relative density is 1.04, becomes component 1;

Step 3: step 2 Chinese medicine slag is added to 4-6 times of water gaging and soak 1-2.5 hour, extract once, extraction time is 1.5-2 hour, and thickening filtration is extractum shape, is component 2;

Step 4: said components 1 and 2 two kinds of extractum of component are condensed into pasty state, add the powder that a step obtains, add Mel and be twisted into pill.

When the dosage form of described Chinese medicine is tablet, its preparation method comprises the following steps:

The first step, is mixed in proportion each described Chinese medicine raw medicinal material, the ethanol that to add with respect to the determining alcohol of 4～5 times of mixture qualities be 85%～90%, and reflux 2～4 hours, extracts, and filters and obtains the first extracting solution; The ethanol that it is 90%～95% that the medicinal residues that filtration obtains add with respect to the determining alcohol of 2～3 times of described medicinal residues quality again, reflux 1～3 hour, extracts, and filters and obtains the second extracting solution; The first extracting solution and the second extracting solution are merged, and concentrating under reduced pressure is removed alcohol solvent, dry, obtains and gets dry extract;

Second step, the dry cream that the first step is obtained is placed in super micron mill to be pulverized 2～3 hours, pulverizes, and sieves, and obtains 300 order～400 object micropowders;

The 3rd step, the micropowders that second step is obtained, add with respect to the microcrystalline Cellulose of 0.1～0.3 times of its quality, 0.15～0.3 times of lactose, the starch of 0.2～0.35 times, sieve, mix homogeneously, granulate, dry, add with respect to 0.025～0.04 times of magnesium stearate of micropowders quality, granulate, tabletting, makes.

When the dosage form of described Chinese medicine is capsule, its preparation method comprises the following steps:

The first step, Poria, Semen Coicis, Stigma Maydis, Semen Hoveniae (Fructus Hoveniae), Pericarpium Citri Reticulatae, the Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Citri Sarcodactylis, Fructus Citri, Bulbus Allii Macrostemonis, Pericarpium Arecae and Semen Canavaliae are mixed in described ratio, add the water extraction volatile oil with respect to 4～6 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtaining, the mass ratio of volatile oil and beta-schardinger dextrin-is 1: 3～6, stirs 30 DEG C～50 DEG C of temperature 60 minutes～90 minutes, obtain volatile oil clathrate compound, for subsequent use; The clear paste that while separately aqueous extract being concentrated into 60 DEG C, relative density is 1.15～1.17;

Second step, Semen Raphani, fevervine, Semen Sinapis Albae, Flos Inulae, Rhizoma Cynanchi Stauntonii, Radix Platycodonis, Fructus Perillae, Folium Rhododendri Daurici, Radix Physochlainae and Flos Farfarae are mixed in described ratio, the alcohol reflux that to add with respect to 5～8 times, mixture amount determining alcohols be 75%～90% 3～5 times, each 2～3 hours, filter respectively, each time filtrate merges, and reclaims ethanol, the clear paste that while being concentrated into 60 DEG C, relative density is 1.20～1.22, for subsequent use;

The 3rd step, will remain described raw medicinal material and mix in described ratio, add with respect to 8～10 times of water gagings of mixture, boil 6～8 hours, filter the clear paste that while being concentrated into 60 DEG C, relative density is 1.28～1.30;

The 4th step, mixes the clear paste of the first step, second step, the 3rd step, and 60 DEG C～70 DEG C reduced vacuum are dry, and powder gets dry extract;

The 5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, add subsequently the mixture with respect to volatile oil clathrate compound described in 100 weight portions and dried cream powder, 5～7 weight portion carboxymethyl starch sodium, 5～50 weight portion starch mix homogeneously, adding 150～200 weight portion determining alcohols is 80%～90% alcohol granulation, dry, granulate, add subsequently the mixture with respect to volatile oil clathrate compound described in 100 weight portions and dried cream powder, 3～5 weight portion magnesium stearate, then pack in gelatine capsule.

The invention has the beneficial effects as follows: the present invention has effect of warming YANG to promote diuresis, cure mainly type of water overflowing caused by insuffi ciency of YANG chronic cardiac insufficiency, the present invention utilizes Traditional Chinese medical theory, and great attention to whole is seen, by adjusting whole blood circulation, improve body circulation and pulmonary circulation QI and blood, carry out determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, capable of regulating arrhythmia, controls blood pressure, improve Electrolyte imbalance in body, strengthen cardiac pumping function, improve respiratory function etc., many target spots, the drug effect focus of going directly, evident in efficacy, safe and effective, convenient drug administration, patient is easy to accept, and can obviously improve patient's quality of life.

Detailed description of the invention

The invention provides a kind of Chinese medicine for the treatment of type of water overflowing caused by insuffi ciency of YANG chronic cardiac insufficiency, wherein, comprise following raw medicinal material: Poria, Semen Coicis, Stigma Maydis, Semen Hoveniae (Fructus Hoveniae), Pericarpium Citri Reticulatae, the Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Citri Sarcodactylis, Fructus Citri, Bulbus Allii Macrostemonis, Pericarpium Arecae, Semen Canavaliae, Semen Raphani, fevervine, Semen Sinapis Albae, Flos Inulae, Rhizoma Cynanchi Stauntonii, Radix Platycodonis, Fructus Perillae, Folium Rhododendri Daurici, Radix Physochlainae, Flos Farfarae, Cortex Mori, Radix Codonopsis, Rhizoma Dioscoreae, Radix Et Caulis Acanthopanacis Senticosi, Placenta Hominis, Herba Cynomorii, Rhizoma Polygonati Odorati, field grasswort and Flos Caraganae Sinicae.

Wherein, Poria, Semen Coicis, Stigma Maydis, the infiltration of Semen Hoveniae (Fructus Hoveniae) dampness removing; Pericarpium Citri Reticulatae, the Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Citri Sarcodactylis, Fructus Citri, Bulbus Allii Macrostemonis, Pericarpium Arecae, Semen Canavaliae, Semen Raphani, fevervine circulation of qi promoting spleen invigorating, diuretic, reducing swelling and alleviating pain; Semen Sinapis Albae, Flos Inulae, Rhizoma Cynanchi Stauntonii, Radix Platycodonis, Fructus Perillae, Folium Rhododendri Daurici, Radix Physochlainae, Flos Farfarae, Cortex Mori lowering the adverse-rising QI to resolve phlegm, relieving cough and asthma; Radix Codonopsis, Rhizoma Dioscoreae, Radix Et Caulis Acanthopanacis Senticosi, Placenta Hominis, Herba Cynomorii, Rhizoma Polygonati Odorati, field grasswort and Flos Caraganae Sinicae QI invigorating kidney tonifying warming YANG.

Wherein, the pharmacology of above-mentioned raw materials medical material is as follows:

Poria: sweet, light, flat.GUIXIN warp, lung meridian, spleen channel, kidney channel.Diuretic medicine; Diuretics with the action of eliminating dampness.

Semen Coicis: cool in nature, sweet in the mouth, light.Return spleen, stomach, lung meridian.There is the effect such as invigorating spleen to remove dampness, clearing away heat and discharging pus, be applicable to have loose bowels, muscle arteries and veins contracture joint stuffiness, the diseases such as edema, beriberi, acute appendicitis, leucorrhea.

Stigma Maydis: sweet, light, flat.Return bladder, liver, gallbladder meridian.Inducing diuresis to remove edema, suppressing the hyperactive liver function of gallbladder promoting.For acute and chronic nephritis, edema, acute hepatitis, chronic hepatitis, hypertension, diabetes, chronic sinusitis, lithangiuria, Biliary Calculi, the diseases such as dysuria, damp and hot jaundice.And can prevent habitual abortion.

Semen Hoveniae (Fructus Hoveniae): property is flat, sweet in the mouth.GUIXIN warp, spleen channel.The relieving restlessness of quenching the thirst, moistening five ZANG-organs, sharp defecation, goes heat on diaphragm, and function is as honey.The relieving restlessness of quenching the thirst, disappears damp and hot, alcoholic intoxication.

Pericarpium Citri Reticulatae: nature and flavor hardship, pungent, temperature.Return lung, spleen channel.There is regulating qi-flowing for strengthening spleen, the function of drying dampness to eliminate phlegm.Can be used for fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.

The Radix Aucklandiae: pungent, hardship, warm in nature.Return spleen, large intestine, tri-jiao channel.Circulation of qi promoting, pain relieving, spleen invigorating, helps digestion.Promoting the circulation of QI to relieve pain; Intestinal stasis relieving in tune.Main born of the same parents coerce distension foot, and abdominal distention, tells and have loose bowels, heavy after dysentery.

Lignum Aquilariae Resinatum: pungent, bitter, temperature.Return spleen, stomach, kidney, lung meridian.In tune, tonifying five ZANG-organs, nourishing essence and tonifying YANG, warm waist knee joint, gas uncharms.Ending tendon transfer, vomiting and diarrhoea, cold air, broken disease addiction, (controlling) cold wind paralysis, joint is not appointed, and wet wind skin is itched, cardiac and abdominal pain, diarrhea due to disorder of qi.

Fructus Citri Sarcodactylis: pungent, bitter, sour, temperature.Return liver, spleen, lung meridian.Tonifying liver warming the stomach, preventing or arresting vomiting is told, and the Fructus Citri Sarcodactylis cold syndrome of the stomach expectorant that disappears, controls gastric qi pain, the only cold pain of face, and middle circulation of qi promoting.Control gas soothing liver-QI, stomach function regulating reduces phlegm, and removing mass is controlled dysphagia and regurgitation, eliminating mass abdominal mass scrofula.

Fructus Citri: acrid in the mouth, sweet is nontoxic.Function depressed liver-energy dispersing and QI regulating, the chest stuffiness relieving reduces phlegm, dehumidifying and in.Cure mainly the therapeutic method to keep the adverse QI flowing downwards, except mind expectorant water.

Bulbus Allii Macrostemonis: acrid in the mouth, hardship, warm in nature.Gui Jing, lung, the heart, stomach, large intestine channel.Be attributed to bone.Except cold and heat, the gas that anhydrates, warming middle-JIAO eliminating stagnation.Wind and cold edema in all skin ulcers, to be coated with it.Have and regulate the flow of vital energy, the chest stuffiness relieving, activates yang, eliminating stagnation, effect of intestinal stasis relieving.Cure mainly the thorough back of the body of obstruction of qi in the chest and cardialgia, breast gastral cavity painful abdominal mass is vexed, cough with asthma abundant expectoration, epigastric pain, let out after dysentery heavy, leucorrhea, furuncle carbuncle.

Pericarpium Arecae: acrid in the mouth, slightly warm in nature.Return spleen, stomach, large intestine, small intestine meridian.The main cold and hot gas abdomen of making a psychological attack, large intestine is stopped up poison, expectorant diaphragm, the belching of acid from stomach.And decoct with Jiang Yantong, enter to dredge gas medicine good.Therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO, line water detumescence.For retention of damp leading to blockage of QI, breast abdominal distention is vexed, defecate not well, and edema, beriberi, dysuria.

Semen Canavaliae: warm in nature, property is flat, and sweet in the mouth is nontoxic.The kidney invigorating, cold expelling, the therapeutic method to keep the adverse QI flowing downwards, sharp the intestines and stomach, preventing or arresting vomiting is told.Control kidney qi deficient, the intestines and stomach discord, vomiting, abdominal distention, vomits and diarrhoea.Warming the middle warmer and descending qi.Profit the intestines and stomach, preventing or arresting vomiting is told, kidney tonifying invigorating primordial QI.

Semen Raphani: pungent, sweet, flat.Return lung, spleen, stomach warp.The de-swelling that helps digestion, lowering the adverse-rising QI to resolve phlegm.For retention of food and drink, abdominal distention, constipation, stagnant dysentery, expectorant heap soil or fertilizer over and around the roots is breathed with cough.

Fevervine: property is flat, sweet in the mouth, micro-hardship.GUIXIN; Liver; Spleen; Kidney channel.Expelling wind and activating blood circulation, analgesic antidotal, dyspepsia and intestinal stasis relieving, dehumidifying detumescence.Dispelling the wind and dampness pathogens pain, diarrhoea dysentery, dirty abdomen pain, deficiency of vital energy edema, dizzy lack of appetite, hepatosplenomegaly, scrofula, acute appendicitis, innominate toxic swelling, traumatic injury.

Semen Sinapis Albae: acrid in the mouth, temperature, nontoxic.Return the warp of liver, spleen, lung, stomach, the heart and collaterals of the uterus.Can remove cold air, settling five organs, by the expectorant of film diaphragm, wards off stealthy gas, the addiction that disappears malaria, and the Dingchuan that drops interests, sharp key improving eyesight, removing blood stasis relieves the pain, and all can prove effective.Can energy dissipating fall, energy complementary energy liter, helps all tonics, the outstanding kind merit of receiving.

Flos Inulae: salty, warm.Return lung, liver, stomach warp.Function expectorant, the therapeutic method to keep the adverse QI flowing downwards, softening the hard mass, row water.Cure mainly in the heart expectorant knot, the lower distension of the side of body, cough with asthma, singultus, saliva is as shellac varnish, epigastric oppression Ying, eructation unrelieved, extensive abdominal edema.

Rhizoma Cynanchi Stauntonii: pungent, bitter, tepor.Return lung meridian.Lowering the adverse-rising QI to resolve phlegm, cough-relieving.Cough with copious phlegm, asthma.

Radix Platycodonis: bitter in the mouth, pungent, property is flat.Return lung meridian.There is lung qi dispersing, eliminate the phlegm, sore-throat relieving, evacuation of pus, sharp the five internal organs, effect of filling blood, mend five kinds of over strain, fostering the spirit of nobility.Cure mainly cough with copious phlegm, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, dysentery stomachache, aphtha of the mouth and tongue, conjunctival congestion and swelling pain, uroschesis.For cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia, hoarseness, lung abscess vomiting pus, skin infection difficulty in discharging of pus.

Fructus Perillae: pungent, temperature.Return lung, spleen channel.Can relieving the exterior syndrome by diaphoresis, regulating the flow of QI to ease the stomach, solving toxin of fish and crab.For anemofrigid cold, headache, cough, distension and fullness of the chest and abdomen, fish Eriocheir sinensis is poisoning.Folium Perillae acrid in the mouth warm in nature, have induce sweat, cold expelling, the effect of regulating the flow of vital energy and seeking.

Folium Rhododendri Daurici: pungent, bitter, cold in nature, mild toxicity.Return lung meridian.Cough-relieving; Eliminate the phlegm.Main acute and chronic bronchitis.

Radix Physochlainae: sweet micro-bitterness, hot in nature, poisonous.Tonify deficiency, warming middle-JIAO, calms the nerves, Dingchuan.Control impairment caused by overstrain weak, diarrhea due to deficiency-cold, insomnia, palpitation and being susceptible to fright, cough phlegm dyspnea, night sweat spontaneous perspiration.。

Flos Farfarae: acrid in the mouth, warm in nature.Return lung meridian.Profit cardiopulmonary, beneficial the five internal organs, relieving restlessness, benefit labor is bad, stopping coughing and removing phlegm, pulmonary fistula is spitted blood, and the palpitation with fear of having a guilty conscience, washes liver improving eyesight and apoplexy.

Cortex Mori: Gan Han.Return lung meridian.Main go aqueous vapor in lung, only hemoptysis, heat is thirsty, edema, abdominal distention, sets out swollenly, and dredging water passages, goes cun whitely, can stitch gold wound.Function eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema.

Radix Codonopsis: property is flat, sweet in the mouth, micro-acid.Return spleen, lung meridian.Invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.For deficiency of the spleen and lung, the cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency cough, interior-heat is quenched one's thirst.

Rhizoma Dioscoreae: sweet in the mouth, property is flat.Return lung, spleen, kidney channel.There is strengthening the spleen and tonifying the lung, stomach reinforcing the kidney invigorating, the benefit of reinforcing the kidney essence, hearing-improing and eyesight improving, help that the five internal organs, bone and muscle strengthening, long will are calmed the nerves, effect of life lengthening, cure mainly that weakness of the spleen and stomach, lassitude, inappetence, chronic diarrhea and dysentery, insufficiency of lung-QI are dry, phlegm dyspnea cough, kidney qi loss, soreness of the waist and knees, lower limb flaccidity are weak, the red card such as swollen, fat of the frequent micturition of quenching one's thirst, the premature ejaculation of passing out semen, leukorrhagia nebulousurine, skin.

Radix Et Caulis Acanthopanacis Senticosi: acrid in the mouth, hardship, micro-sweet, warm in nature.Return spleen, kidney, heart channel.There is replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization, effect of expelling wind and removing dampness, soft for anemofrigid-damp arthralgia, lumbocrural pain, muscles and bones flaccidity, be slow in action, a little less than body weakness with emaciation, traumatic injury, fracture, edema, beriberi, the uncontrolled urination card such as itch.

Placenta Hominis: sweet, salty, warm.Return lung, the heart, kidney channel.QI invigorating, nourishes blood, benefit essence.Control deficient, weakness and emaciation, consumptive fever hectic fever due to YIN-deficiency, cough with asthma, spitting of blood, night sweat, seminal emission, sexual impotence, women's vim and vigour deficiency, infertile or newborn few.

Herba Cynomorii: sweet, temperature.Return spleen, kidney, large intestine channel.Kidney-replenishing, benefiting essence-blood, loosening bowel to relieve constipation.Soft for waist knee joint flaccidity, sexual impotence spermatorrhea, dryness of the intestine constipation.

Rhizoma Polygonati Odorati: sweet, be slightly cold.Attach to the lung and stomach meridians.Nourishing YIN to relieve dryness, promoting the production of body fluid to quench thirst.For lung stomach-Yin wound, cough caused by dryness-heat, dry throat and mouth, interior-heat is quenched one's thirst.

Field grasswort: light; Warm in nature.Nourishing YIN and invigorating YANG.Main negative and positive virtual loss card.

Flos Caraganae Sinicae: sour, puckery, temperature.Kidney invigorating and YANG supporting, synthetism hemostasis.For impotence due to deficiency of the kidney; Wound hemorrhage is controlled in external, injury and bone fracture.

Wherein, in Chinese medicine, the ratio of weight and number of each raw medicinal material is: Poria 21-34 part, Semen Coicis 19-35 part, Stigma Maydis 24-36 part, Semen Hoveniae (Fructus Hoveniae) 13-28 part, Pericarpium Citri Reticulatae 15-31 part, Radix Aucklandiae 17-34 part, Lignum Aquilariae Resinatum 8-20 part, Fructus Citri Sarcodactylis 19-36 part, Fructus Citri 23-36 part, Bulbus Allii Macrostemonis 16-27 part, Pericarpium Arecae 26-38 part, Semen Canavaliae 11-27 part, Semen Raphani 7-19 part, fevervine 13-25 part, Semen Sinapis Albae 19-32 part, Flos Inulae 7-11 part, Rhizoma Cynanchi Stauntonii 22-36 part, Radix Platycodonis 18-31 part, Fructus Perillae 13-30 part, Folium Rhododendri Daurici 6-14 part, Radix Physochlainae 5-12 part, Flos Farfarae 10-24 part, Cortex Mori 11-26 part, Radix Codonopsis 14-30 part, Rhizoma Dioscoreae 15-31 part, Radix Et Caulis Acanthopanacis Senticosi 22-37 part, Placenta Hominis 5-13 part, Herba Cynomorii 7-19 part, Rhizoma Polygonati Odorati 14-28 part, field grasswort 12-28 part and Flos Caraganae Sinicae 4-10 part.

Wherein, in Chinese medicine, the ratio of weight and number of each raw medicinal material is: Poria 21-30 part, Semen Coicis 20-33 part, Stigma Maydis 26-34 part, Semen Hoveniae (Fructus Hoveniae) 15-25 part, Pericarpium Citri Reticulatae 17-29 part, Radix Aucklandiae 19-31 part, Lignum Aquilariae Resinatum 8-17 part, Fructus Citri Sarcodactylis 19-33 part, Fructus Citri 25-32 part, Bulbus Allii Macrostemonis 18-25 part, Pericarpium Arecae 29-38 part, Semen Canavaliae 12-24 part, Semen Raphani 8-17 part, fevervine 15-23 part, Semen Sinapis Albae 21-30 part, Flos Inulae 7-10 part, Rhizoma Cynanchi Stauntonii 24-33 part, Radix Platycodonis 19-29 part, Fructus Perillae 15-28 part, Folium Rhododendri Daurici 7-13 part, Radix Physochlainae 5-11 part, Flos Farfarae 12-21 part, Cortex Mori 13-21 part, Radix Codonopsis 14-26 part, Rhizoma Dioscoreae 15-29 part, Radix Et Caulis Acanthopanacis Senticosi 25-35 part, Placenta Hominis 6-11 part, Herba Cynomorii 7-14 part, Rhizoma Polygonati Odorati 16-26 part, field grasswort 14-25 part and Flos Caraganae Sinicae 5-9 part.

Wherein, in Chinese medicine, the ratio of weight and number of each raw medicinal material is: 30 parts, Poria, 27 parts of Semen Coiciss, 34 parts of Stigma Maydis, 25 parts of Semen Hoveniae (Fructus Hoveniae)s, 17 parts of Pericarpium Citri Reticulataes, 28 parts of the Radix Aucklandiae, 8 parts of Lignum Aquilariae Resinatum, 19 parts of Fructus Citri Sarcodactylis, 32 parts of Fructus Citris, 22 parts of Bulbus Allii Macrostemonis, 38 parts of Pericarpium Arecae, 17 parts of Semen Canavaliaes, 8 parts of Semen Raphanis, 23 parts of fevervines, 21 parts of Semen Sinapis Albaes, 7 parts of Flos Inulae, 24 parts of Rhizoma Cynanchi Stauntoniis, 29 parts of Radix Platycodoniss, 16 parts of Fructus Perillaes, 7 parts of Folium Rhododendri Daurici, 5 parts of Radix Physochlainae, 14 parts of Flos Farfaraees, 21 parts of Cortex Mori, 26 parts of Radix Codonopsis, 22 parts of Rhizoma Dioscoreaes, 35 parts of Radix Et Caulis Acanthopanacis Senticosis, 9 parts of Placenta Hominiss, 14 parts of Herba Cynomoriis, 21 parts of Rhizoma Polygonati Odorati, 5 parts of 14 parts of field grassworts and Flos Caraganae Sinicaes.

Wherein, in Chinese medicine, the ratio of weight and number of each raw medicinal material is: 21 parts, Poria, 20 parts of Semen Coiciss, 26 parts of Stigma Maydis, 19 parts of Semen Hoveniae (Fructus Hoveniae)s, 29 parts of Pericarpium Citri Reticulataes, 31 parts of the Radix Aucklandiae, 17 parts of Lignum Aquilariae Resinatum, 33 parts of Fructus Citri Sarcodactylis, 25 parts of Fructus Citris, 25 parts of Bulbus Allii Macrostemonis, 29 parts of Pericarpium Arecae, 24 parts of Semen Canavaliaes, 17 parts of Semen Raphanis, 19 parts of fevervines, 30 parts of Semen Sinapis Albaes, 10 parts of Flos Inulae, 33 parts of Rhizoma Cynanchi Stauntoniis, 19 parts of Radix Platycodoniss, 15 parts of Fructus Perillaes, 13 parts of Folium Rhododendri Daurici, 11 parts of Radix Physochlainae, 21 parts of Flos Farfaraees, 13 parts of Cortex Mori, 14 parts of Radix Codonopsis, 15 parts of Rhizoma Dioscoreaes, 25 parts of Radix Et Caulis Acanthopanacis Senticosis, 11 parts of Placenta Hominiss, 7 parts of Herba Cynomoriis, 26 parts of Rhizoma Polygonati Odorati, 6 parts of 25 parts of field grassworts and Flos Caraganae Sinicaes.

Wherein, in Chinese medicine, the ratio of weight and number of each raw medicinal material is: 26 parts, Poria, 33 parts of Semen Coiciss, 28 parts of Stigma Maydis, 15 parts of Semen Hoveniae (Fructus Hoveniae)s, 22 parts of Pericarpium Citri Reticulataes, 19 parts of the Radix Aucklandiae, 10 parts of Lignum Aquilariae Resinatum, 30 parts of Fructus Citri Sarcodactylis, 26 parts of Fructus Citris, 18 parts of Bulbus Allii Macrostemonis, 37 parts of Pericarpium Arecae, 12 parts of Semen Canavaliaes, 10 parts of Semen Raphanis, 15 parts of fevervines, 26 parts of Semen Sinapis Albaes, 9 parts of Flos Inulae, 26 parts of Rhizoma Cynanchi Stauntoniis, 23 parts of Radix Platycodoniss, 28 parts of Fructus Perillaes, 10 parts of Folium Rhododendri Daurici, 6 parts of Radix Physochlainae, 12 parts of Flos Farfaraees, 15 parts of Cortex Mori, 18 parts of Radix Codonopsis, 29 parts of Rhizoma Dioscoreaes, 30 parts of Radix Et Caulis Acanthopanacis Senticosis, 6 parts of Placenta Hominiss, 11 parts of Herba Cynomoriis, 16 parts of Rhizoma Polygonati Odorati, 9 parts of 18 parts of field grassworts and Flos Caraganae Sinicaes.

Wherein, in the time that the dosage form of Chinese medicine is honey refining pill, its preparation method comprises the following steps:

Wherein, in the time that the dosage form of Chinese medicine is tablet, its preparation method comprises the following steps:

Wherein, in the time that the dosage form of Chinese medicine is capsule, its preparation method comprises the following steps:

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.

Embodiment 1 honey refining of the present invention pill

Get Poria 30g, Semen Coicis 27g, Stigma Maydis 34g, Semen Hoveniae (Fructus Hoveniae) 25g, Pericarpium Citri Reticulatae 17g, Radix Aucklandiae 28g, Lignum Aquilariae Resinatum 8g, Fructus Citri Sarcodactylis 19g, Fructus Citri 32g, Bulbus Allii Macrostemonis 22g, Pericarpium Arecae 38g, Semen Canavaliae 17g, Semen Raphani 8g, fevervine 23g, Semen Sinapis Albae 21g, Flos Inulae 7g, Rhizoma Cynanchi Stauntonii 24g, Radix Platycodonis 29g, Fructus Perillae 16g, Folium Rhododendri Daurici 7g, Radix Physochlainae 5g, Flos Farfarae 14g, Cortex Mori 21g, Radix Codonopsis 26g, Rhizoma Dioscoreae 22g, Radix Et Caulis Acanthopanacis Senticosi 35g, Placenta Hominis 9g, Herba Cynomorii 14g, Rhizoma Polygonati Odorati 21g, field grasswort 14g and Flos Caraganae Sinicae 5g.

Its preparation method comprises the following steps:

Step 2: get again surplus stock medical material and mix in described ratio, add 94% soak with ethanol 1 hour, heating extraction 2 times with respect to 3 times of amounts of mixture, each 1.5 hours, merge extractive liquid,, 150 orders filter, be 98000 ultrafiltration post ultrafiltration again through the molecular weight that dams, the extractum that when ultrafiltrate is evaporated to 87 DEG C, relative density is 1.04, becomes component 1;

Step 3: step 2 Chinese medicine slag is added to 4-6 times of water gaging and soak 2 hours, extract once, extraction time is 2 hours, and thickening filtration is extractum shape, is component 2;

Embodiment 2 tablet of the present invention

Get Poria 21g, Semen Coicis 20g, Stigma Maydis 26g, Semen Hoveniae (Fructus Hoveniae) 19g, Pericarpium Citri Reticulatae 29g, Radix Aucklandiae 31g, Lignum Aquilariae Resinatum 17g, Fructus Citri Sarcodactylis 33g, Fructus Citri 25g, Bulbus Allii Macrostemonis 25g, Pericarpium Arecae 29g, Semen Canavaliae 24g, Semen Raphani 17g, fevervine 19g, Semen Sinapis Albae 30g, Flos Inulae 10g, Rhizoma Cynanchi Stauntonii 33g, Radix Platycodonis 19g, Fructus Perillae 15g, Folium Rhododendri Daurici 13g, Radix Physochlainae 11g, Flos Farfarae 21g, Cortex Mori 13g, Radix Codonopsis 14g, Rhizoma Dioscoreae 15g, Radix Et Caulis Acanthopanacis Senticosi 25g, Placenta Hominis 11g, Herba Cynomorii 7g, Rhizoma Polygonati Odorati 26g, field grasswort 25g and Flos Caraganae Sinicae 6g.

Its preparation method comprises the following steps:

The first step, is mixed in proportion each described Chinese medicine raw medicinal material, the ethanol that to add with respect to the determining alcohol of 5 times of mixture qualities be 90%, and reflux 3 hours, extracts, and filters and obtains the first extracting solution; The ethanol that it is 95% that the medicinal residues that filtration obtains add with respect to the determining alcohol of 2 times of described medicinal residues quality again, reflux 3 hours, extracts, and filters and obtains the second extracting solution; The first extracting solution and the second extracting solution are merged, and concentrating under reduced pressure is removed alcohol solvent, dry, obtains and gets dry extract;

Second step, the dry cream that the first step is obtained is placed in super micron mill to be pulverized 3 hours, pulverizes, and sieves, and obtains 400 object micropowders;

The 3rd step, the micropowders that second step is obtained, adds with respect to the microcrystalline Cellulose of 0.3 times of its quality, 0.15 times of lactose, the starch of 0.2 times, sieves, mix homogeneously, granulates, dry, adds with respect to 0.04 times of magnesium stearate of micropowders quality, granulate, tabletting, makes.

Embodiment 3 capsule of the present invention

Get Poria 26g, Semen Coicis 33g, Stigma Maydis 28g, Semen Hoveniae (Fructus Hoveniae) 15g, Pericarpium Citri Reticulatae 22g, Radix Aucklandiae 19g, Lignum Aquilariae Resinatum 10g, Fructus Citri Sarcodactylis 30g, Fructus Citri 26g, Bulbus Allii Macrostemonis 18g, Pericarpium Arecae 37g, Semen Canavaliae 12g, Semen Raphani 10g, fevervine 15g, Semen Sinapis Albae 26g, Flos Inulae 9g, Rhizoma Cynanchi Stauntonii 26g, Radix Platycodonis 23g, Fructus Perillae 28g, Folium Rhododendri Daurici 10g, Radix Physochlainae 6g, Flos Farfarae 12g, Cortex Mori 15g, Radix Codonopsis 18g, Rhizoma Dioscoreae 29g, Radix Et Caulis Acanthopanacis Senticosi 30g, Placenta Hominis 6g, Herba Cynomorii 11g, Rhizoma Polygonati Odorati 16g, field grasswort 18g and Flos Caraganae Sinicae 9g.

Its preparation method comprises the following steps:

The first step, Poria, Semen Coicis, Stigma Maydis, Semen Hoveniae (Fructus Hoveniae), Pericarpium Citri Reticulatae, the Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Citri Sarcodactylis, Fructus Citri, Bulbus Allii Macrostemonis, Pericarpium Arecae and Semen Canavaliae are mixed in described ratio, add the water extraction volatile oil with respect to 5 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtaining, the mass ratio of volatile oil and beta-schardinger dextrin-is 1: 4, stirs 40 DEG C of temperature 90 minutes, obtain volatile oil clathrate compound, for subsequent use; The clear paste that while separately aqueous extract being concentrated into 60 DEG C, relative density is 1.16;

Second step, Semen Raphani, fevervine, Semen Sinapis Albae, Flos Inulae, Rhizoma Cynanchi Stauntonii, Radix Platycodonis, Fructus Perillae, Folium Rhododendri Daurici, Radix Physochlainae and Flos Farfarae are mixed in described ratio, the alcohol reflux that to add with respect to 6 times, mixture amount determining alcohols be 90% 4 times, each 2 hours, filter respectively, each time filtrate merges, and reclaims ethanol, the clear paste that while being concentrated into 60 DEG C, relative density is 1.21, for subsequent use;

The 3rd step, will remain described raw medicinal material and mix in described ratio, add with respect to 9 times of water gagings of mixture, boil 7 hours, filter the clear paste that while being concentrated into 60 DEG C, relative density is 1.29;

The 4th step, mixes the clear paste of the first step, second step, the 3rd step, and 70 DEG C of reduced vacuum are dry, and powder gets dry extract;

The 5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, add subsequently the mixture with respect to volatile oil clathrate compound described in 100 weight portions and dried cream powder, 6 weight portion carboxymethyl starch sodium, 7 weight portion starch mix homogeneously, adding 155 weight portion determining alcohols is 90% alcohol granulation, dry, granulate, add subsequently the mixture with respect to volatile oil clathrate compound described in 100 weight portions and dried cream powder, 4 weight portion magnesium stearate, then pack in gelatine capsule.

Oral medicinal herb pharmaceutical dosage form of the present invention is preferably: tablet, film coated tablet, enteric coated tablet, sugar coated tablet, capsule, soft capsule, oral liquid, hard capsule, suck agent, electuary, honey pill agent, granule, powder, sublimed preparation, solution, syrup; External used medicine dosage form is preferably: ointment, injection, liniment, ointment, fumigant, patch, suppository, tincture, plaster, gel and spray.

Said medicine is decocted in use decoction and is taken, and 1 dose of every day, decocting takes at twice, and every 30 days is a course for the treatment of; In the time that this Chinese medicine refines pill, capsule or sucks agent, tablet use for honey, three times on the one, every 30 days is a course for the treatment of; In the time that this Chinese medicine is spray use, 3-5 time on the one, every 30 days is a course for the treatment of; In the time that this Chinese medicine is ointment, patch, suppository, plaster, gel use, 1 time on the one, every 30 days is a course for the treatment of.

Toxicity test:

Acute toxicity test: 60 of application NIH mices, SPF level, male and female half and half, body weight 17～24g, carries out acute toxicity test.Mice is divided into two groups at random, and 20 every group, i.e. matched group and administration group, fasting 12 hours before experiment; Tablet dissolved prepared by embodiments of the invention 2 is in water, (concentration is 5.74g crude drug/ml, maximum concentration) gavage, gavage volume is that 5ml/kg(is that single-dose dosage is 28.7 crude drugs/kg), matched group gives equivalent normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: with matched group comparison, after administration, mice has no notable difference, experiment Continuous Observation 14 days, and mice overall health of patients, diet, drinking-water, body weight gain are all normal.Mice oral administration gavage tablet LD50>28.7 of the present invention crude drug/kg, every day, maximum dosage-feeding was 57.4 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention is 4.6g crude drug/day/people, becomes body weight for humans in 60KG, and average dosage is 0.077g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is taking 21g) oral administration gavage Chinese medicine of the present invention is 745 times of quantity.Therefore the tablet acute toxicity of the embodiment of the present invention 2 is low, clinical drug safety.

Long term toxicity test: by the honey refining pill of the embodiment of the present invention 1 to mice by 6.43,15.72 and 16 weeks (1.0ml/100g body weight of 36.41g crude drug/kg continuous use, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as the hair of Chinese medicine preparation of the present invention to mice, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat all has no significant effect, internal organs naked eyes do not find that difference changes and histological examination result shows, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that toxicity is little after Chinese medicine preparation of the present invention is to mice long-term prescription, after drug withdrawal, also there is no difference reaction, application safety.

Long term toxicity test: by the capsule of the embodiment of the present invention 3 to mice by 6.43,15.72 and 16 weeks (1.0ml/100g body weight of 36.41g crude drug/kg continuous use, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as the hair of Chinese medicine preparation of the present invention to mice, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat all has no significant effect, internal organs naked eyes do not find that difference changes and histological examination result shows, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that toxicity is little after Chinese medicine preparation of the present invention is to mice long-term prescription, after drug withdrawal, also there is no difference reaction, application safety.

Diagnostic criteria:

Chronic cardiac insufficiency diagnostic criteria:

This diagnostic criteria of diagnosing patients with heart failure standard of Framingham is divided into main standard and minor criteria.Meet two main standard or a main standard and two minor criteria persons, diagnosable is heart failure.Main standard comprises: 1. paroxysmal nocturnal dyspnea.2. distension of jugular vein.3. lung rale.4. cardiac dilatation.5. acute lung edema.3. third heart sound is gallop rhythm.7. venous pressure rising (>16cmH2O).Minor criteria comprises: 1. deep edema.2. nocturnal cough.3. movable rear dyspnea.4. hepatomegaly.5. hydrothorax.3. vital capacity is reduced to 1/3 of forced vital capacity.7. tachycardia (>=120 times/min).Main and minor criteria includes: treatment more than 5 days, after the time, loses weight >=4.5kg.

Cardiac functional grading

I level (cardiac functional compensatory period): only have heart disease sign, physical exertion is unrestricted, general physical exertion does not cause the symptoms such as fatigue, cardiopalmus, dyspnea or angina pectoris.II level: be equivalent to heart failure I degree or slight.Physical exertion is slightly restricted, asymptomatic when rest, but (as above 3rd floors, upward slope, walking 1500～2000m) cause the symptoms such as tired, cardiopalmus, dyspnea or angina pectoris when general physical exertion.When inspection, except the sign of heart itself, still can find heart rate quickening, liver silght enlargement etc.

III level: be equivalent to heart failure II degree or moderate.Physical exertion is obviously limited, asymptomatic when rest, but cardiopalmus, dyspnea, symptoms of heart failure appear in slight physical exertion (as above second floor, upper clivia, walking 500～1000m), or ictal angina pectoris.Liver moderate swelling while having a medical check-up, and have edema to a certain degree, after lying up, take a turn for the better, but can not disappear completely.IV level: be equivalent to heart failure III degree or severe.Not competent any physical exertion, still has the sings and symptoms of heart failure when quiet rest, or has anginal syndrome.Internal organs congestion and edema are remarkable.Patients on long-term can have the changes such as cardiac cirrhosis.

The traditional Chinese medical science is divided into type of deficiency of QI of both the heart and lung, type of deficiency of both QI and YIN, Qi deficiency blood stasis type, type of water overflowing caused by insuffi ciency of YANG, phlegm-heat obstructing lung type according to different syndrome characteristics.

Type of water overflowing caused by insuffi ciency of YANG: shortness of breath and palpitation, maybe must not put down sleepingly, cough up and tell frothy sputum, face limb edema, aversion to cold and cold limbs, irritated perspiration, face amount is greyish white, cyanotic lips, oliguria abdominal distention, or companion's hydrothorax, ascites, tongue is dim or dark red, white and slippery fur, short or knot generation of thready pulse.

Clinical data:

Case selection: get the court in, in June, 2012 to 2013 year outpatient service in August and type of water overflowing caused by insuffi ciency of YANG chronic cardiac insufficiency patient 160 examples of accepting for medical treatment in hospital as object of study, wherein, male 96 examples, female's 64 examples; Age 59-80 year, wherein 65 years old 85 example of age 59-, over-65s 75 examples, course of disease 1-9, wherein valvular heart disease 35 examples, hypertensive heart disease 41 examples, coronary heart disease 52 examples, dilated cardiomyopathy 32 examples, cardiac function II--IV level.Be divided at random four groups, four groups of patients' ordinary circumstance is as no difference of science of statistics such as sex, age, the courses of disease, and (P < 0.05), has comparability.

Honey refining pill treatment group: 40 people, male 24 people, female 16 people.

Tablet in treatment group: 40 people, male 24 people, female 16 people.

Capsule treatment group: 40, male 24 people, female 16 people.

Western medicine group: 40 people, male 24 people, female 16 people.

Therapeutic Method:

Honey refining pill treatment group: take honey refining pill prepared by the embodiment of the present invention 1, every day 3 times, each 4 30 days is 1 course for the treatment of.

Tablet in treatment group: take tablet prepared by the embodiment of the present invention 2, every day 3 times, each 4 30 days is 1 course for the treatment of.

Capsule treatment group: take capsule prepared by the embodiment of the present invention 3, every day 3 times, each 4 30 days is 1 course for the treatment of.

Western medicine group: oral 1 time of use hydrochlorothiazide 25mg every other day; Digoxin 0.125mg, oral 1 time of every day; Sorbitrate 10mg, oral 3 times of every day.Pay close attention to patient's rhythm of the heart situation, detect every life index, symptomatic treatment in time, taking 30 days as 1 course for the treatment of.

Efficacy assessment standard:

The criterion of cure of chronic cardiac insufficiency:

(1) definitely cure (curing completely): 1. heart rate declines, and reaches digitalization standard, still keeps stable after physical exertion.2. heart failure sign (recessive and dominant) is disappeared completely.3. level when body weight reaches without heart failure.4. can tolerate general physical work, heart function recovery is to one-level.5. can tolerate full diet (having salt diet).

(2) relatively cure (clinical cure, part is cured): although 1. heart rate declines, unstable, after physical exertion, still have rising.2. there are some recessive heart failure signs still to exist.3. can not tolerate general physical exertion, cardiac function is in II～III level.4. can not tolerate full diet (only can less salt).5. heart failure easily recurs.

The curative effect determinate standard of chronic cardiac insufficiency:

Effective: can reach complete criterion of cure person, or cardiac function to improve the above person of II level.

Effective: can reach part criterion of cure person, cardiac function improves I level, generally in I～II level; Symptom and sign alleviate, but still have some symptoms of heart failure to exist.

Invalid: cardiac function improves not enough I level; Or symptom and sign are without improvement, even add severe one.

Therapeutic outcome:

Referring to table 1 and table 2, as can be seen from Table 1, adopt treatment by Chinese herbs type of water overflowing caused by insuffi ciency of YANG chronic cardiac insufficiency of the present invention, on therapeutic effect, there is significant improvement with respect to Western medicine; As can be seen from Table 2, adopt treatment by Chinese herbs type of water overflowing caused by insuffi ciency of YANG chronic cardiac insufficiency of the present invention, with respect to Western medicine, treating significantly shortening on the course for the treatment of.

Four groups, table 1 is treated respectively Clinical efficacy comparison example after 30 days

Group	Number of cases	Effective	Effectively	Invalid	Total effective rate
						Honey refining pill treatment group	40	31	8	1	97.5%
Tablet in treatment group	40	30	9	1	97.5%
						Capsule treatment group	40	32	8	0	100%
Western medicine group	40	13	22	5	87.5%

Four groups, table 2 is treated respectively effective and effective number and time comparative example (%) after 30 days

Group	Number of cases	1-10 days	11-20 days	21-30 days
					Honey refining pill treatment group	39	12(30.8%)	18(46.2%)	9(23.1%)
Tablet in treatment group	39	15(38.5%)	14(35.9%)	10(25.6%)
					Capsule treatment group	40	16(40.0%)	16(40.0%)	8(20.0%)
Western medicine group	35	9(25.7%)	12(34.3%)	14(40.0 %)

Known according to the clinical statistics in above table, that Chinese medicine provided by the invention has is rapid-action, effective percentage is high, determined curative effect, safe, the advantage that has no side effect.

Model case: land, female, 66 years old, first visit on May 3 in 2013.Uncomfortable in chest because panting, can not put down sleeping emergency treatment and be admitted to hospital.Electrocardio diagram left atrium load increases the weight of, left ventricular enlargement, complete left bundle branch block.Heart color ultrasound is shown diastole end of term left ventricular interior diameter 70mm, and myocardial movement diffusivity weakens, EF value 32%, and blood pressure 100/60mmHg, Analysis of blood lipid, blood glucose, blood flow becomes normal.Be diagnosed as dilated cardiomyopathy, Ⅲcardiac function (NYHA standard).The disease opinion QI rising in reverse order of breathing with cough, resting on the bedstead to sleep is difficult to flat sleeping, and cough up and tell frothy sputum, palpitation uneasiness, urine amount is few, dim complexion, cyanosis of the lips and nails, tongue dimness, white, slippery and moist fur, deep-thready pulse.Be diagnosed as yang deficiency flashing type chronic cardiac insufficiency.Take the capsule of Chinese medicine preparation embodiment 3 of the present invention, every day 3 times, each 4, treat 10 days effective, continue to take medicine 20 days, heart function recovery reaches cardiac function I level, leaves hospital, and indirectly takes 2 years, health does not recur so far.

The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any amendment of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.

Claims

1. treat the Chinese medicine of type of water overflowing caused by insuffi ciency of YANG chronic cardiac insufficiency for one kind, it is characterized in that, comprise following raw medicinal material: Poria, Semen Coicis, Stigma Maydis, Semen Hoveniae (Fructus Hoveniae), Pericarpium Citri Reticulatae, the Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Citri Sarcodactylis, Fructus Citri, Bulbus Allii Macrostemonis, Pericarpium Arecae, Semen Canavaliae, Semen Raphani, fevervine, Semen Sinapis Albae, Flos Inulae, Rhizoma Cynanchi Stauntonii, Radix Platycodonis, Fructus Perillae, Folium Rhododendri Daurici, Radix Physochlainae, Flos Farfarae, Cortex Mori, Radix Codonopsis, Rhizoma Dioscoreae, Radix Et Caulis Acanthopanacis Senticosi, Placenta Hominis, Herba Cynomorii, Rhizoma Polygonati Odorati, field grasswort and Flos Caraganae Sinicae.

2. Chinese medicine according to claim 1, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Poria 21-34 part, Semen Coicis 19-35 part, Stigma Maydis 24-36 part, Semen Hoveniae (Fructus Hoveniae) 13-28 part, Pericarpium Citri Reticulatae 15-31 part, Radix Aucklandiae 17-34 part, Lignum Aquilariae Resinatum 8-20 part, Fructus Citri Sarcodactylis 19-36 part, Fructus Citri 23-36 part, Bulbus Allii Macrostemonis 16-27 part, Pericarpium Arecae 26-38 part, Semen Canavaliae 11-27 part, Semen Raphani 7-19 part, fevervine 13-25 part, Semen Sinapis Albae 19-32 part, Flos Inulae 7-11 part, Rhizoma Cynanchi Stauntonii 22-36 part, Radix Platycodonis 18-31 part, Fructus Perillae 13-30 part, Folium Rhododendri Daurici 6-14 part, Radix Physochlainae 5-12 part, Flos Farfarae 10-24 part, Cortex Mori 11-26 part, Radix Codonopsis 14-30 part, Rhizoma Dioscoreae 15-31 part, Radix Et Caulis Acanthopanacis Senticosi 22-37 part, Placenta Hominis 5-13 part, Herba Cynomorii 7-19 part, Rhizoma Polygonati Odorati 14-28 part, field grasswort 12-28 part and Flos Caraganae Sinicae 4-10 part.

3. Chinese medicine according to claim 1, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Poria 21-30 part, Semen Coicis 20-33 part, Stigma Maydis 26-34 part, Semen Hoveniae (Fructus Hoveniae) 15-25 part, Pericarpium Citri Reticulatae 17-29 part, Radix Aucklandiae 19-31 part, Lignum Aquilariae Resinatum 8-17 part, Fructus Citri Sarcodactylis 19-33 part, Fructus Citri 25-32 part, Bulbus Allii Macrostemonis 18-25 part, Pericarpium Arecae 29-38 part, Semen Canavaliae 12-24 part, Semen Raphani 8-17 part, fevervine 15-23 part, Semen Sinapis Albae 21-30 part, Flos Inulae 7-10 part, Rhizoma Cynanchi Stauntonii 24-33 part, Radix Platycodonis 19-29 part, Fructus Perillae 15-28 part, Folium Rhododendri Daurici 7-13 part, Radix Physochlainae 5-11 part, Flos Farfarae 12-21 part, Cortex Mori 13-21 part, Radix Codonopsis 14-26 part, Rhizoma Dioscoreae 15-29 part, Radix Et Caulis Acanthopanacis Senticosi 25-35 part, Placenta Hominis 6-11 part, Herba Cynomorii 7-14 part, Rhizoma Polygonati Odorati 16-26 part, field grasswort 14-25 part and Flos Caraganae Sinicae 5-9 part.

4. according to the arbitrary described Chinese medicine of claim 1-3, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: 30 parts, Poria, 27 parts of Semen Coiciss, 34 parts of Stigma Maydis, 25 parts of Semen Hoveniae (Fructus Hoveniae)s, 17 parts of Pericarpium Citri Reticulataes, 28 parts of the Radix Aucklandiae, 8 parts of Lignum Aquilariae Resinatum, 19 parts of Fructus Citri Sarcodactylis, 32 parts of Fructus Citris, 22 parts of Bulbus Allii Macrostemonis, 38 parts of Pericarpium Arecae, 17 parts of Semen Canavaliaes, 8 parts of Semen Raphanis, 23 parts of fevervines, 21 parts of Semen Sinapis Albaes, 7 parts of Flos Inulae, 24 parts of Rhizoma Cynanchi Stauntoniis, 29 parts of Radix Platycodoniss, 16 parts of Fructus Perillaes, 7 parts of Folium Rhododendri Daurici, 5 parts of Radix Physochlainae, 14 parts of Flos Farfaraees, 21 parts of Cortex Mori, 26 parts of Radix Codonopsis, 22 parts of Rhizoma Dioscoreaes, 35 parts of Radix Et Caulis Acanthopanacis Senticosis, 9 parts of Placenta Hominiss, 14 parts of Herba Cynomoriis, 21 parts of Rhizoma Polygonati Odorati, 5 parts of 14 parts of field grassworts and Flos Caraganae Sinicaes.

5. according to the arbitrary described Chinese medicine of claim 1-3, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: 21 parts, Poria, 20 parts of Semen Coiciss, 26 parts of Stigma Maydis, 19 parts of Semen Hoveniae (Fructus Hoveniae)s, 29 parts of Pericarpium Citri Reticulataes, 31 parts of the Radix Aucklandiae, 17 parts of Lignum Aquilariae Resinatum, 33 parts of Fructus Citri Sarcodactylis, 25 parts of Fructus Citris, 25 parts of Bulbus Allii Macrostemonis, 29 parts of Pericarpium Arecae, 24 parts of Semen Canavaliaes, 17 parts of Semen Raphanis, 19 parts of fevervines, 30 parts of Semen Sinapis Albaes, 10 parts of Flos Inulae, 33 parts of Rhizoma Cynanchi Stauntoniis, 19 parts of Radix Platycodoniss, 15 parts of Fructus Perillaes, 13 parts of Folium Rhododendri Daurici, 11 parts of Radix Physochlainae, 21 parts of Flos Farfaraees, 13 parts of Cortex Mori, 14 parts of Radix Codonopsis, 15 parts of Rhizoma Dioscoreaes, 25 parts of Radix Et Caulis Acanthopanacis Senticosis, 11 parts of Placenta Hominiss, 7 parts of Herba Cynomoriis, 26 parts of Rhizoma Polygonati Odorati, 6 parts of 25 parts of field grassworts and Flos Caraganae Sinicaes.

6. according to the arbitrary described Chinese medicine of claim 1-3, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: 26 parts, Poria, 33 parts of Semen Coiciss, 28 parts of Stigma Maydis, 15 parts of Semen Hoveniae (Fructus Hoveniae)s, 22 parts of Pericarpium Citri Reticulataes, 19 parts of the Radix Aucklandiae, 10 parts of Lignum Aquilariae Resinatum, 30 parts of Fructus Citri Sarcodactylis, 26 parts of Fructus Citris, 18 parts of Bulbus Allii Macrostemonis, 37 parts of Pericarpium Arecae, 12 parts of Semen Canavaliaes, 10 parts of Semen Raphanis, 15 parts of fevervines, 26 parts of Semen Sinapis Albaes, 9 parts of Flos Inulae, 26 parts of Rhizoma Cynanchi Stauntoniis, 23 parts of Radix Platycodoniss, 28 parts of Fructus Perillaes, 10 parts of Folium Rhododendri Daurici, 6 parts of Radix Physochlainae, 12 parts of Flos Farfaraees, 15 parts of Cortex Mori, 18 parts of Radix Codonopsis, 29 parts of Rhizoma Dioscoreaes, 30 parts of Radix Et Caulis Acanthopanacis Senticosis, 6 parts of Placenta Hominiss, 11 parts of Herba Cynomoriis, 16 parts of Rhizoma Polygonati Odorati, 9 parts of 18 parts of field grassworts and Flos Caraganae Sinicaes.

7. according to the arbitrary described Chinese medicine of claim 1-6, it is characterized in that, when the dosage form of described Chinese medicine is honey refining pill, its preparation method comprises the following steps:

8. according to the arbitrary described Chinese medicine of claim 1-4, it is characterized in that, when the dosage form of described Chinese medicine is tablet, its preparation method comprises the following steps:

9. according to the arbitrary described Chinese medicine of claim 1-4, it is characterized in that, when the dosage form of described Chinese medicine is capsule, its preparation method comprises the following steps: