CN106109932A - A kind of whitening and speckle dispelling Chinese medicine composition, whitening and speckle dispelling Chinese medicine preparation, whitening and speckle dispelling facial cream, preparation method - Google Patents
A kind of whitening and speckle dispelling Chinese medicine composition, whitening and speckle dispelling Chinese medicine preparation, whitening and speckle dispelling facial cream, preparation method Download PDFInfo
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- CN106109932A CN106109932A CN201610577215.9A CN201610577215A CN106109932A CN 106109932 A CN106109932 A CN 106109932A CN 201610577215 A CN201610577215 A CN 201610577215A CN 106109932 A CN106109932 A CN 106109932A
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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Abstract
The present invention relates to Chinese medicinal skin care technical field, be specifically related to a kind of whitening and speckle dispelling Chinese medicine composition, whitening and speckle dispelling Chinese medicine preparation, whitening and speckle dispelling facial cream, preparation method.This Chinese medicine composition is made up of following raw material: Flos Tulipae Gesnerianae extract 2～4 parts, Radix Notoginseng extract 2～4 parts, Radix Rehmanniae Preparata extract 3～5 parts, Semen Persicae extract 5～7 parts, Radix Ophiopogonis extract 2～4 parts, Rhizoma Cyperi extract 2～4 parts, Radix Bupleuri extract 2～4 parts, Rhizoma Atractylodis Macrocephalae extract 3～5 parts, Fructus Forsythiae berry extract 2～4 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) root extract 3～5 parts, Radix Salviae Miltiorrhizae extract 2～4 parts, river Radix Paeoniae Rubra extract 5～7 parts, opoponax extract 3～5 parts, Poria extract 2～4 parts, Flos Carthami extract 2～4 parts, licorice root extract 2.5～5.5 parts, Radix Angelicae Sinensis extract 2～4 parts.This Chinese medicine composition blood circulation promoting and blood stasis dispelling, dredging the meridian, holding up spleen qi-restoratives, conditioning endocrine, safety and effectivity solves the problem that the face speckle such as chloasma is difficult to desalinate easily recurrence.
Description
Technical field
The present invention relates to Chinese medicinal skin care technical field, be specifically related in a kind of whitening and speckle dispelling Chinese medicine composition, whitening and speckle dispelling
Medicine preparation, whitening and speckle dispelling facial cream, preparation method.
Background technology
Chloasma is also referred to as chloasma hepaticum and butterfly spot, and for filbert or brown spot, border is more visible, in irregular shape,
Be symmetrically distributed near eye socket, forehead, geisoma, nose, two cheeks, lip and mouth week etc. no conscious sympton and general malaise, belong to
A kind of symptom of facial melanosis, is to occur at the pigmentation spots of face.Endocrine disturbance, inherited genetic factors, ultraviolet radiation,
Cosmetic applications is improper, the factor such as women special physiological phase and stress, makes human skin oxidation resistance be decreased obviously, black
Pigementation, skin becomes dark yellow coarse, lacks life, then produces chloasma, have a strong impact on external image.Field, market at present
In speckle dispelling product, it is mostly by the way of adding and using suppression TYR enzyme or promote stratum corneum, from the table of skin
The color of layer desalination speckle, is only capable of reaching the effect of the light speckle in top layer, forms the illusion of speckle dispelling, easily recur.Additionally add use
TYR enzyme inhibitor and promote stratum corneum product and all exist and make skin become sensitive side effect, and deposit after a procedure
Meet ultraviolet irradiation to decompose and aoxidize, the melanin deposition at skin surface can be accelerated, even cause the color of speckle to add
Deeply.Therefore, research and develop there is good safety, stability, inhibition is obvious, cost performance is good natural freckle-diminishing produce
Product, it has also become one of main direction of studying of current medicine and cosmetic industry.
Chinese medicine has no side effect owing to it is natural, is applied in cosmetics and medicine can reach skin treating and the dual merit of skin protection
Effect, and gradually pursued by people.The traditional Chinese medical science thinks that the formation Etiologic Mechanism of the speckles such as chloasma is attributed to " empty, the stasis of blood " two words,
Functional disorder dirty with liver,spleen,kidney three is closely related, and Chinese medical discrimination is the dirty functional disorder of liver,spleen,kidney three, and deficiency of qi and blood, the stasis of blood are stagnant is
Its basic pathological changes.Depression of liver-QI, the stagnation of QI hyperamization stasis of blood；Fire of suffering from a deficiency of the kidney is dry, and heat in blood is stagnant forms the stasis of blood；Deficiency of the spleen causing weakness of QI, anemia void is lost and is pushed away
Move and also can cause the stasis of blood；Final QI and blood can not flourish face, pigmentation forms chloasma.In the above-mentioned traditional Chinese medical science for chloasma diagnosis and treatment
Theoretical direction under, people the most gradually research and develop Chinese medicine composition reach treat chloasma effect, such as Chinese patent
CN105708979A discloses a kind of traditional Chinese medicine freckle-removing compositions, by Rhizoma Chuanxiong, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Salviae Miltiorrhizae, Flos Chrysanthemi, Radix Angelicae Sinensis, Olibanum and Fructus Lycii
Composition.In order to meet people's demand for efficiency natural speckle dispelling product further, for the product of the speckle dispelling of natural Chinese medicine composition
Product carry out the research goed deep into and innovate, and become current problem demanding prompt solution.
Summary of the invention
In order to overcome the defect of prior art, an object of the present invention is to provide a kind of whitening and speckle dispelling Chinese medicine composition
Thing, has notable efficient therapeutical effect for skin of face speckles such as chloasma, has effect of skin whitening simultaneously.
The two of the purpose of the present invention are to provide a kind of whitening and speckle dispelling Chinese medicine preparation.
The three of the purpose of the present invention are to provide a kind of whitening and speckle dispelling facial cream.
The four of the purpose of the present invention are to provide the preparation method of a kind of whitening and speckle dispelling facial cream.
In order to realize object above, the technical solution adopted in the present invention is:
A kind of whitening and speckle dispelling Chinese medicine composition, is made up of the raw material of following parts by weight: Flos Tulipae Gesnerianae extract 2～4 parts, three
Seven extracts 2～4 parts, Radix Rehmanniae Preparata extract 3～5 parts, Semen Persicae extract 5～7 parts, Radix Ophiopogonis extract 2～4 parts, Rhizoma Cyperi carry
Take thing 2～4 parts, Radix Bupleuri extract 2～4 parts, Rhizoma Atractylodis Macrocephalae extract 3～5 parts, Fructus Forsythiae berry extract 2～4 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) root extract 3
～5 parts, Radix Salviae Miltiorrhizae extract 2～4 parts, river Radix Paeoniae Rubra extract 5～7 parts, opoponax extract 3～5 parts, Poria extract 2～4
Part, Flos Carthami extract 2～4 parts, licorice root extract 2.5～5.5 parts, Radix Angelicae Sinensis extract 2～4 parts.
Preferably, above-mentioned whitening and speckle dispelling Chinese medicine composition, it is made up of the raw material of following parts by weight: Flos Tulipae Gesnerianae extract 3
Part, Radix Notoginseng extract 3 parts, Radix Rehmanniae Preparata extract 4 parts, 6 parts of Semen Persicae extract, Radix Ophiopogonis extract 3 parts, Rhizoma Cyperi extract 3 parts,
Radix Bupleuri extract 3 parts, Rhizoma Atractylodis Macrocephalae extract 4 parts, Fructus Forsythiae berry extract 3 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) root extract 4 parts, Radix Salviae Miltiorrhizae extract 3 parts, river
Radix Paeoniae Rubra extract 6 parts, opoponax extract 4 parts, Poria extract 3 parts, Flos Carthami extract 3 parts, licorice root extract 3.6 parts,
Radix Angelicae Sinensis extract 3 parts.
A kind of whitening and speckle dispelling Chinese medicine preparation, including above-mentioned whitening and speckle dispelling Chinese medicine composition, pharmaceutical preparation or cosmetic formulations
Adjuvant needed for preparation.
A kind of whitening and speckle dispelling facial cream, including the adjuvant needed for above-mentioned whitening and speckle dispelling Chinese medicine composition, facial cream preparation.
Optionally, above-mentioned whitening and speckle dispelling facial cream, the raw material of following parts by weight it is prepared from: above-mentioned whitening and speckle dispelling Chinese medicine
Compositions 60～63 parts, glycerol 20～25 parts, carbomer 4～6 parts, PLURONICS F87 3.5～5.5 parts, propylene glycol 3～5 parts,
Sodium hydroxide 0.5～1 part, imidazolidinyl urea 0.5～1 part, coceth-7 0.2～0.4 parts, PPG-1-PEG-9 Laurel two
Alcohol ether 0.05～0.2 part, Cremophor RH40 0.03～0.08 part, hyaluronic acid 0.35～0.55 part, methyl hydroxybenzoate 0.3
～0.5 part, Margarita powder 0.1～0.3 part, 2-bromo-2-nitropropane-1,3-glycol 0.1～0.2 part, disodiumedetate
0.1～0.2 part, Rosa centifolia L caul-fat 0.1～0.3 part, water 295～305 parts.
Preferably, above-mentioned whitening and speckle dispelling facial cream, the raw material of following parts by weight it is prepared from: above-mentioned whitening and speckle dispelling Chinese medicine
Compositions 61.6 parts, glycerol 22 parts, carbomer 5.2 parts, PLURONICS F87 4.4 parts, propylene glycol 4 parts, sodium hydroxide 0.832
Part, imidazolidinyl urea 0.8 part, coceth-7 0.3 parts, PPG-1-PEG-9 Laurel glycol ethers 0.12 part, PEG-40 hydrogenation
Oleum Ricini 0.06 part, hyaluronate sodium 0.44 part, methyl hydroxybenzoate 0.4 part, Margarita powder 0.2 part, 2-bromo-2-nitropropane-1,3-
Glycol 0.16 part, disodiumedetate 0.16 part, Rosa centifolia L caul-fat 0.2 part, 299.248 parts of water.
Above-mentioned whitening and speckle dispelling facial cream with whitening and speckle dispelling Chinese medicine composition of the present invention as effective ingredient, and add use glycerol,
Propylene glycol and hyaluronate sodium are compounding as wetting agent, the wetting agent synergism of three kinds of different molecular structures, reduce single guarantor
The consumption of humectant, improves the performance of keeping humidity of clear paste, compares one-component wetting agent and makes the performance of keeping humidity of clear paste of preparation improve
70%, be conducive to keeping the activity of Chinese medicine ingredients so that Chinese traditional medicine molecule can permeate with Continuous slow release, wetting agent enters through pore
During cell, the effective ingredient carrying Chinese medicine composition enters cell, promotes that the transdermal of Effective Component of Chinese Medicine is inhaled by cell
Receive, continuous action, improve effect of the freckle removing and whitening of facial cream；Adding use PLURONICS F87 is emulsifying agent, adds cocoanut oil alcohol and gathers
Ether-7, PPG-1-PEG-9 Laurel glycol ethers, Cremophor RH40 are compounding as solubilizing agent, add Carmomer as thickening
Agent, interpolation disodiumedetate, as chelating agen, emulsifying agent and compounding solubilizing agent synergism, improves the matter of clear paste
Structure, promotes more Effective Component of Chinese Medicine to be dissolved into medicine film layer, and drug effect improves 58%, improves skin to effective ingredient saturating in clear paste
Skin absorbent properties, simultaneously compounding solubilizing agent reduces the consumption of single solubilizing agent, reduces single solubilizing agent excessive use to facial cream
The impact of Transdermal absorption performance；Add imidazolidinyl urea, methyl hydroxybenzoate and 2-bromo-2-nitropropane-1,3-glycol and compound conduct
Preservative, extends the shelf life of facial cream, avoids the consumption of single preservative simultaneously, reduce single preservative excessive use to skin
Have side effects；Add and use sodium hydroxide, the flora environment of auxiliary adjustment skin, prevent skin bacterium and fungal infection, rise
Effect to skin protection.
Above-mentioned facial cream is prepared from whitening and speckle dispelling Chinese medicine composition of the present invention for effective ingredient, and Cutaneous permeation is passed through in external
To interior circulation, environment in improving and adjusting, through outer and interior, the combination of inner and outside, treating both the principal and secondary aspects of a disease, safety and effectivity solves the faces such as chloasma
Speckle problem is not easy recurrence.
The preparation method of above-mentioned whitening and speckle dispelling facial cream, including following operating procedure:
(1) take part water and add carbomer, after soaking 10～15 hours, carry out homogenizing and be completely dispersed to carbomer, add
Sodium hydroxide, mix homogeneously, obtain mixed material 1, standby；By PLURONICS F87, hyaluronate sodium, 2-bromine 2-nitropropane-1,
3-glycol adds in remaining water, and mix homogeneously obtains mixed material 2, standby；Being added by propylene glycol in methyl hydroxybenzoate, mixing is all
Even, obtain mixed material 3, standby；Take Rosa centifolia L caul-fat and add coceth-7, PPG-1-PEG-9 Laurel glycol ethers, PEG-40
Castor oil hydrogenated, mix homogeneously, obtain mixed material 4；
(2) mixed material 2 is added in mixed material 1, mix homogeneously, obtain mixed material 5；
(3) in mixed material 5 add Flos Tulipae Gesnerianae extract, Radix Notoginseng extract, Radix Rehmanniae Preparata extract, Semen Persicae extract,
Radix Ophiopogonis extract, Rhizoma Cyperi extract, Radix Bupleuri extract, Rhizoma Atractylodis Macrocephalae extract, Fructus Forsythiae berry extract, Pseudobulbus Bletillae (Rhizoma Bletillae) root extract, Radix Salviae Miltiorrhizae
Extract, river Radix Paeoniae Rubra extract, opoponax extract, Poria extract, Flos Carthami extract, licorice root extract, Radix Angelicae Sinensis extract
Thing, glycerol, Margarita powder, imidazolidinyl urea, disodiumedetate, mix homogeneously, obtain mixed material 6；
(4) in mixed material 6, add mixed material 3, mix homogeneously, obtain mixed material 7；Mixed material 7 adds
Mixed material 4, mix homogeneously, obtain described clear paste.
In step (1), in mixed material 1 homogenizing process, homogenizing rotating speed is 25r/min, and homogenizing time is 10～15 minutes.
Above-mentioned each Chinese medicine extract is prepared by following methods: put into by raw material of Chinese medicine in Chinese medicine extracting tank, adds 10
The water of times amount, after ebuillition of heated 3 hours, goes out liquid, is filtrated to get Chinese medicine extract, standby.
Active component abbreviated functional description:
Semen Persicae: primary efficacy is blood stasis dispelling dehumidifying, expansion blood vessel, can alleviate cutaneous pigmentation for speckle dispelling, promote blood
Circulation, acceleration bodies endotoxin excretes.
Flos Carthami: effect mainly has a promoting blood circulation to restore menstrual flow, blood stasis dispelling, for speckle dispelling can dredging the meridian, eliminate be deposited on skin black
Pigment, dredging the meridian, acceleration toxin expelling.
Radix Bupleuri: bitter in the mouth, gas is put down, is slightly cold.Abnormal smells from the patient is all light, rises and does not drops, and Yang Zhongyin is also, nontoxic.Enter brothers few positive, the moon of fainting
Four warps.The heresy of eliminating pathogen in the liver gallbladder, goes epigastric oppression vexed, solves expectorant knot, heat clearing away and restlessness relieving, especially controls skin infection, dissipates all poly-through blood clotting gas, only migraine, breast
Side of body twinge, sensible the exterior and the interior pathogen, kind solution hectic fever.Radix Bupleuri enters between the exterior and the interior, the sensible meridians of energy, therefore can be that assistant makes, and property is light
Be slightly cold clearly, place of arrival, spring breeze is gentle, is good at solving confused, thus with it, should not be also.Radix Bupleuri is used for speckle dispelling, divides in adjustable
Secrete, allay excitement with all worries set aside, it is possible to effectively alleviate the root cause problems that mottle produces.
River Radix Paeoniae Rubra: nature and flavor are bitter, are slightly cold, return Liver Channel.Primarily serve the purpose of clearing away heat and cooling blood, eliminating stasis to stop pain.For maculae caused by violent heat pathogen, tell
Blood epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen stomachache, injury from falling down, carbuncle skin infection.In terms of speckle dispelling, Radix Paeoniae Rubra
Toxin expelling can be played, weaken mottle, nurse one's health endocrine effect simultaneously.
Rhizoma Cyperi: effect is mainly regulated the flow of vital energy resolving depression, menstruction regulating and pain relieving, for stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, digestion is not
Good, menoxenia, amenorrhea dysmenorrhea, colic of cold type stomachache, distending pain of the breast.It is used in medicine for removing speckle, plays adjustment endocrine, alleviation equally
Patient's anxious state of mind concurrently facilitates the effect of toxin expelling.
Radix Curcumae: nature and flavor are pungent, bitter, cold, return liver, the heart, return lung meridian.Primary efficacy is: regulating qi to disperse stagnation, heart fire-clearing upset-relieving, and function of gallbladder promoting moves back
Yellow.For the main endocrine regulation of speckle dispelling, alleviate the effect such as emotion, toxin expelling.
The Pseudobulbus Bletillae (Rhizoma Bletillae): bitter, sweet, puckery, is slightly cold.Return lung, liver, stomach warp.Whitening and speckle dispelling, astringing to arrest bleeding, detumescence and promoting granulation.The Pseudobulbus Bletillae (Rhizoma Bletillae) is the most just
It is beauty treatment good medicine, is described as " whitening fairy maiden ", the dermatosiss such as acne, tinea corporis, cicatrix can be treated." property of medicine opinion " cloud its " control on face
Skin ulcer, makes us flesh sliding ".Compendium of Material Medica cloud its " wash one's face black, speckle dispelling ".Main Function is the metabolism promoting cell, promotes poison
Element is discharged, desalination skin color and smooth skin.
The Rhizoma Atractylodis Macrocephalae: bitter in the mouth, sweet, warm in nature.Return spleen, stomach warp." property of medicine opinion " is recorded: " interarea light is pleased, speckle dispelling of preserving youthful looks "." medical science enters
Door " wide Chinese medicine beautifying side's " three plain soup " of spreading of recording is described: the Rhizoma Atractylodis Macrocephalae, the insufficiency of the spleen deficiency of vital energy can be treated, invigorating qi and benefiting blood,
Whitening and moistening skin, is suitable to pachylosis, sallow, chloasma, pigmentation etc. that QI and blood deficiency and coldness causes.The Rhizoma Atractylodis Macrocephalae has the merit of slow down aging
Effect, has specially good effect for skin whitening, the skin the most vaporific epidermophyton of pathomycete etc. is had inhibitory action.
Radix Notoginseng: nature and flavor hardship sweet, micro-, temperature.Radix Notoginseng returns through returning liver, stomach warp.Radix Notoginseng has a heat clearing away suppressing the hyperactive liver, tranquilizing by nourishing the heart, lung moistening,
Preserve youth defying age, eliminate and reduce the effect such as wrinkle of skin and chloasma.It is particularly suited for the beauty treatment of women, skin protection, is female
Property the most natural good beauty and skin care skin care product, it can defying age, protect skin, improve skin appearance, make skin emolliency also
Increase elasticity.Mainly by effect of invigorating blood circulation of Radix Notoginseng, blood circulation promoting and the metabolism of cell, discharge toxin alluvial.
Radix Rehmanniae Preparata: sweet in the mouth, slightly warm in nature, have nourishing YIN and supplementing blood, benefit essence fill out the effects such as marrow.Cure mainly the hepatic and renal YIN deficiency, soreness of the waist and knees,
The diseases such as the seminal emission of osteopyrexia and fever, night sweat, interior-heat are quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, vertigo and tinnitus, early whitening of beard and hair.
Treat heat in blood of suffering from a deficiency of the kidney, reduce and eliminate blood stasis, promote cell metabolism.
Radix Glycyrrhizae: primary efficacy has scattered pathogenic factor in the exterior, subduing inflammation, sore-throat relieving pain, solves hundred poison of drug, except stomach accumulated heat, goes urinary catheter pain, and this is sweet cool
The power of heat extraction is also.Processing the invigorating middle warmer by temperature, main insufficiency of the spleen cunning is rushed down, and insufficiency of stomach is thirsty, and cold and heat are coughed, speckle dispelling medication take its strengthening the spleen and stomach, removing toxic substances,
Dissipate effect of pathogenic factor in the exterior, to conditioning viscera, disintegrate and metabolism black have obvious curative effect.
Radix Angelicae Sinensis: primary efficacy has replenishing and activating blood, menstruction regulating and pain relieving, loosening bowel to relieve constipation.During traditional Chinese medicine freckle-removing, take its above-mentioned merit just
Effect, to nurse one's health endocrine, accelerates toxin expelling, vivotoxin can be prevented simultaneously to be detained due to long-time, formed by intestinal absorption
Mottle.Therefore, treatment and prevention mottle there is direct effect.
Fructus Forsythiae: function cures mainly heat clearing away, removing toxic substances, eliminating stagnation, detumescence.Control warm, erysipelas, macule, carbuncle and ulcer toxic swelling, scrofula, urine
Stranguria with urinary obstruction.
Radix Ophiopogonis: sweet in the mouth, micro-hardship, cold in nature, enter the heart, lung, stomach three warp.There is effect of clearing away heart-fire and moistening the lung, nourishing the stomach to promote the production of body fluid.For heat
Sick impairment of body fluid, asthenia dysphoria with smothery sensation, clearing away heart-fire and moistening the lung, reinforcing YIN-essence benefit essence, relieving restlessness of purging heat, expectorant antitussive, the aquatic Tianjin of row, face is pleased in improving eyesight.Radix Ophiopogonis is clear
Heart relieving restlessness, for insufficiency of heart-YIN, fidgets due to deficiency insomnia and pathogenic warmth are joined the army, fever and irritability, uneasy sleeping at night, and the gas controlling YIN-deficiency of the lung and kidney is weak, empty
Labor hectic fever, deficiency-heat is tired of.
Poria: promoting diuresis to eliminate damp pathogen, spleen invigorating, mind calming.Poria can spleen invigorating, inappetence thin and weak to those prolonged illness or have body concurrently
The tired weak patient of deficiency of vital energy spleen weak, diarrhoea has an effect holding up spleen QI invigorating, and mild in medicine property and.
Radix Salviae Miltiorrhizae: nature and flavor bitter in the mouth, is slightly cold, GUIXIN, Liver Channel.Having blood circulation promoting and blood stasis dispelling, inducing menstruation to relieve menalgia, clear away heart-fire relieving restlessness, removing heat from blood eliminating carbuncle
Effect.
Radix Saposhnikoviae: expelling pathogenic wind from the body surface, removing dampness to relieve pain, spasmolytic, antipruritic, hypo-allergenic.
Above-mentioned whitening and speckle dispelling Chinese medicine composition realizes the guideline of whitening effect: the traditional Chinese medical science is from endogenous cause of ill, by Huang
The generation of brown patch is divided into " qi depression to blood stasis " disease, " insufficiency of the spleen suffer from a deficiency of the kidney " disease, " suffering from a deficiency of the kidney " disease, particularly as follows:
Qi depression to blood stasis disease: blood stored in the liver, main catharsis is adjusted and is reached, and can adjust smooth whole body mechanism of qi, emotion regulation activity, promote blood and body fluid
Defeated cloth metabolism, promote taste transportation capabilities, coordinate man arrange essence, woman ovulation and menstrual onset.Irritability catharsis is too late, liver
Yu Bushu, easily causes depression of liver-QI, can make qi activity disturbance, and QI and blood is disloyal, it is impossible to upper flourish in face, then SHENGHUANG brown patch.It may be said that
The Qi-stagnation type of stasis disease and blood stasis type reciprocal causation, connect each other, influence each other, and blockage of main and collateral channels QI-blood circulation is not smooth, long strongly fragrantization
Transconversion into heat fire, cloudy blood of burning；Or the stagnation of QI causes body fluid dysbolismus, metaplasia expectorant turbid retardance venation, cause face qi-blood disharmony, lose
QI and blood nourish, expectorant stasis of blood foul smell stop, face failure of skin and muscle to be nourished and chloasma occurs.Briefly precisely due to the stagnation of QI causes face
Blood circulation power is poor, and face QI-blood circulation is sluggish slowly causes the silt of facial vessels to hinder, sinking of Ink vessel transfusing metabolite
Long-pending, pigmentation forms chloasma, is mainly in middle-aged women.Visible liver is lost and dredges stagnant, qi depression to blood stasis is that it is basic.
" insufficiency of the spleen suffer from a deficiency of the kidney " disease: spleen-deficient the spleen governs the blood, main transporting the lucid yang sending up, spleen is again the foundation of acquired constitution simultaneously, source of generating QI and blood,
Spleen weakness, blood deficiency can not go up flourish in face, cause the generation of primary disease." General Treatise on the Cause and Symptoms of Diseases " have speech: " the vital organs of the human body 12 warp
Blood, all goes up in face, husband's blood trip all flourish the exterior and the interior ", illustrate that blood deficiency can cause disharmony between QI and blood, puckery or turbid, it is impossible to flourish in skin, thus raw
Black skin care.Blood vessels are hollow, it is impossible to flourish face-beautifying noodle then gives birth to black speck.The deficiency of vital energy can not promoting the circulation of blood, blood stasis follows through stagnating in face, sends out as yellowish-brown
Speckle.Essence and blood sharing the same origin, renal essence generating blood, blood generating essence, inflation foot god is prosperous for essence, then face Rong Run gloss, otherwise the darkest dim the dampest.This card
It is more common in postpartum women or post-abortion, it is possible to seeing eating and drinking without temperance, overstrain, partially addicted to the five tastes, cause dysfunction of the spleen in transportation, QI and blood can not
On Rong Yu；Or soil void can not controlling the water circulation, general in aqueous vapor, QI and blood can not be moistened warm, all can give birth to black speck.The deficiency of vital energy is long just may result in gas " silt
Stagnant ".
Kidney deficiency: China's traditional medical theory is thought, kidney is the congenital foundation, main store essential substances, and kidney essense is the root of people's vital movement
This, essence and blood all plays a part nourishing, profitization to each histoorgan of human body, and the metaplasia of blood relies on the situation of kidney essense, kidney essense
The full nourishing also depending on blood.Essence and blood influence each other, and mutually nourish.Kidney yang is also known as kidney-Yang, for sun the dominator of QI all over the body, to pushing away
The dynamic QI-blood circulation whole body, Rong Run face, and rising gasification body fluid, excretion turbid pathogen all plays an important role.Innate deficiency of YANG in the body, or old
Deficiency of the kidney, or prolonged illness is impairment of the kidney, or excess of sexual intercourse etc., it is impossible to replenishing vital QI with drugs of warm nature passages through which vital energy circulates, congealing cold with blood stasis, face must not Rong Run, and because of kidney-Yang loss,
Rising failure in functioning of QI, turbid yin fills the air face skin, then see that darkish complexion is supported without pool, face mistake and caused chloasma.Deficiency of the kidney yin person, kidney
Water thanks to can not fire processed, hyperactivity of deficient fire, thus fire dryness accumulated in the stomach and intestine become black speck, color is withered the dampest.
In sum, the Etiologic Mechanism of chloasma is formed, and can be attributed to " empty, silt " two words, function dirty with liver,spleen,kidney three
Lacking of proper care closely related, Syndrome Differentiation of Chinese Medicine disease is the dirty functional disorder of liver,spleen,kidney three, and deficiency of qi and blood, the stasis of blood are stagnant is its basic pathological changes.Liver
The stagnation of QI is tied, the stagnation of QI hyperamization stasis of blood；Fire of suffering from a deficiency of the kidney is dry, and heat in blood is stagnant forms the stasis of blood；Deficiency of the spleen causing weakness of QI, anemia void is lost to promote and also can be caused the stasis of blood；Final gas
Blood can not flourish face, pigmentation forms chloasma.Therefore the treatment for chloasma needs blood circulation promoting and blood stasis dispelling, the meridian dredging, fills blood.
Whitening and speckle dispelling Chinese medicine composition of the present invention, by Flos Tulipae Gesnerianae extract, Radix Notoginseng extract, Radix Rehmanniae Preparata extract, Semen Persicae
Extract, Radix Ophiopogonis extract, Rhizoma Cyperi extract, Radix Bupleuri extract, Rhizoma Atractylodis Macrocephalae extract, Fructus Forsythiae berry extract, Pseudobulbus Bletillae (Rhizoma Bletillae) root extract
Thing, Radix Salviae Miltiorrhizae extract, river Radix Paeoniae Rubra extract, opoponax extract, Poria extract, Flos Carthami extract, licorice root extract, when
Return extract to form, each raw material in the amount ranges limited, synergism, blood circulation promoting and blood stasis dispelling, dredging the meridian, hold up spleen qi-restoratives, tune
Reason endocrine, and then reach the effect of fundamentally freckle removing and whitening.Particularly as follows: Semen Persicae extract, Flos Carthami extract, Radix Angelicae Sinensis extraction
Effect that thing, Radix Notoginseng extract, collaborative performance are invigorated blood circulation；River Radix Paeoniae Rubra extract, Radix Salviae Miltiorrhizae extract, Rhizoma Cyperi extract, Flos Tulipae Gesnerianae
Extract, Fructus Forsythiae berry extract work in coordination with the effect playing blood stasis dispelling；Rhizoma Cyperi extract synergic adjustment endocrine, promotes that melanin divides
Solve；Licorice root extract coordinating the actions of various ingredients in a prescription, reduces toxicity；Radix Saposhnikoviae coordinating the actions of various ingredients in a prescription, dissipates wind heat, other blood circulation promoting and blood stasis dispelling compositions collaborative,
Balance wind heat, controls the generation of allergy；Radix Rehmanniae Preparata extract and Rhizoma Atractylodis Macrocephalae extract, treat insufficiency of the spleen suffering from a deficiency of the kidney, YIN nourishing, invigorating qi and benefiting blood.
Radix Bupleuri is allayed excitement with all worries set aside, removes hot and suffocating, and playing a role for other components lays the foundation；The Pseudobulbus Bletillae (Rhizoma Bletillae) promotes cell metabolism, discharges poison
Element, smooth skin.
Detailed description of the invention
Below by specific embodiment, technical scheme is described in detail.
Embodiment 1
A kind of whitening and speckle dispelling Chinese medicine composition, is made up of the raw material of following parts by weight: Flos Tulipae Gesnerianae extract 3 parts, Radix Notoginseng
Extract 3 parts, Radix Rehmanniae Preparata extract 4 parts, 6 parts of Semen Persicae extract, Radix Ophiopogonis extract 3 parts, Rhizoma Cyperi extract 3 parts, Radix Bupleuri carry
Take thing 3 parts, Rhizoma Atractylodis Macrocephalae extract 4 parts, Fructus Forsythiae berry extract 3 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) root extract 4 parts, Radix Salviae Miltiorrhizae extract 3 parts, river Radix Paeoniae Rubra carry
Take thing 6 parts, opoponax extract 4 parts, Poria extract 3 parts, Flos Carthami extract 3 parts, licorice root extract 3.6 parts, Radix Angelicae Sinensis carry
Take thing 3 parts.
A kind of whitening and speckle dispelling facial cream, is prepared from by the raw material of following parts by weight: the present embodiment whitening and speckle dispelling Chinese drug-treated group
Compound 61.6 parts, glycerol 22 parts, carbomer 5.2 parts, PLURONICS F87 4.4 parts, propylene glycol 4 parts, sodium hydroxide 0.832 part,
Imidazolidinyl urea 0.8 part, coceth-7 0.3 parts, PPG-1-PEG-9 Laurel glycol ethers 0.12 part, PEG-40 hydrogenated castor
Oil 0.06 part, hyaluronate sodium 0.44 part, methyl hydroxybenzoate 0.4 part, Margarita powder 0.2 part, 2-bromo-2-nitropropane-1,3-glycol
0.16 part, disodiumedetate 0.16 part, Rosa centifolia L caul-fat 0.2 part, 299.248 parts of water.
The preparation method of above-mentioned whitening and speckle dispelling facial cream, including following operating procedure:
(1) take part water add carbomer, after soaking 10～15 hours, under 25r/min speed of agitator, carry out homogenizing 10～
15 minutes, it is completely dispersed to carbomer, adds sodium hydroxide, mix homogeneously, obtain mixed material 1, standby；By PLURONICS F87,
Hyaluronate sodium, 2-bromine 2-nitropropane-1,3-glycol adds in remaining water, under 25r/min speed of agitator, mix homogeneously,
Obtain mixed material 2, standby；Propylene glycol is added in methyl hydroxybenzoate, under 25r/min speed of agitator, mix homogeneously, obtain mixed material
3, standby；Take Rosa centifolia L caul-fat and add coceth-7, PPG-1-PEG-9 Laurel glycol ethers, Cremophor RH40,
Under 25r/min speed of agitator, mix homogeneously, obtain mixed material 4；
(2) mixed material 2 is added in mixed material 1, under 25r/min speed of agitator, mix homogeneously, obtain mixed material 5；
(3) in mixed material 5 add Flos Tulipae Gesnerianae extract, Radix Notoginseng extract, Radix Rehmanniae Preparata extract, Semen Persicae extract,
Radix Ophiopogonis extract, Rhizoma Cyperi extract, Radix Bupleuri extract, Rhizoma Atractylodis Macrocephalae extract, Fructus Forsythiae berry extract, Pseudobulbus Bletillae (Rhizoma Bletillae) root extract, Radix Salviae Miltiorrhizae
Extract, river Radix Paeoniae Rubra extract, opoponax extract, Poria extract, Flos Carthami extract, licorice root extract, Radix Angelicae Sinensis extract
Thing, glycerol, Margarita powder, imidazolidinyl urea, disodiumedetate, under 25r/min speed of agitator, mix homogeneously, obtain mixing
Material 6；
(4) in mixed material 6, add mixed material 3, under 25r/min speed of agitator, mix homogeneously, obtain mixed material 7；
In mixed material 7, add mixed material 4, under 25r/min speed of agitator, mix homogeneously, obtain described clear paste.
The present embodiment whitening and speckle dispelling Chinese medicine composition can be additionally used in and is prepared as pharmaceutical preparation or cosmetic formulations, as water preparation,
Facial film etc..
After testing, the present embodiment prepares the micro-biology experiment of clear paste: total plate count, yeast and mold sum, excrement are big
Intestinal flora, staphylococcus aureus, Pseudomonas aeruginosa meet the requirement of " cosmetics health specification " (version in 2007)；Hygienization
Learn index: hydrargyrum, arsenic, lead content all meet the requirement of " cosmetics health specification " (version in 2007).
Embodiment 2
A kind of whitening and speckle dispelling Chinese medicine composition, is made up of the raw material of following parts by weight: Flos Tulipae Gesnerianae extract 2 parts, Radix Notoginseng
Extract 2 parts, Radix Rehmanniae Preparata extract 3 parts, 5 parts of Semen Persicae extract, Radix Ophiopogonis extract 2 parts, Rhizoma Cyperi extract 2 parts, Radix Bupleuri carry
Take thing 2 parts, Rhizoma Atractylodis Macrocephalae extract 3 parts, Fructus Forsythiae berry extract 2 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) root extract 3 parts, Radix Salviae Miltiorrhizae extract 2 parts, river Radix Paeoniae Rubra carry
Take thing 5 parts, opoponax extract 3 parts, Poria extract 2 parts, Flos Carthami extract 2 parts, licorice root extract 2.5 parts, Radix Angelicae Sinensis carry
Take thing 2 parts.
A kind of whitening and speckle dispelling facial cream, is prepared from by the raw material of following parts by weight: the present embodiment whitening and speckle dispelling Chinese drug-treated group
Compound 60 parts, glycerol 20 parts, carbomer 4 parts, PLURONICS F87 3.5 parts, propylene glycol 3 parts, sodium hydroxide 0.5 part, imidazolidine
Base urea 0.5 part, coceth-7 0.2 parts, PPG-1-PEG-9 Laurel glycol ethers 0.05 part, Cremophor RH40 0.03
Part, hyaluronate sodium 0.35 part, methyl hydroxybenzoate 0.3 part, Margarita powder 0.1 part, 2-bromo-2-nitropropane-1,3-glycol 0.1 part,
Disodiumedetate 0.1 part, Rosa centifolia L caul-fat 0.3 part, 295 parts of water.
The preparation method of the present embodiment whitening and speckle dispelling facial cream is with embodiment 1.
Embodiment 3
A kind of whitening and speckle dispelling Chinese medicine composition, is made up of the raw material of following parts by weight: Flos Tulipae Gesnerianae extract 4 parts, Radix Notoginseng
Extract 4 parts, Radix Rehmanniae Preparata extract 5 parts, 7 parts of Semen Persicae extract, Radix Ophiopogonis extract 4 parts, Rhizoma Cyperi extract 4 parts, Radix Bupleuri carry
Take thing 4 parts, Rhizoma Atractylodis Macrocephalae extract 5 parts, Fructus Forsythiae berry extract 4 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) root extract 5 parts, Radix Salviae Miltiorrhizae extract 4 parts, river Radix Paeoniae Rubra carry
Take thing 7 parts, opoponax extract 5 parts, Poria extract 4 parts, Flos Carthami extract 4 parts, licorice root extract 5.5 parts, Radix Angelicae Sinensis carry
Take thing 4 parts.
A kind of whitening and speckle dispelling facial cream, is prepared from by the raw material of following parts by weight: the present embodiment whitening and speckle dispelling Chinese drug-treated group
Compound 61.6 parts, glycerol 22 parts, carbomer 5.2 parts, PLURONICS F87 4.4 parts, propylene glycol 4 parts, sodium hydroxide 0.832 part,
Imidazolidinyl urea 0.8 part, coceth-7 0.3 parts, PPG-1-PEG-9 Laurel glycol ethers 0.12 part, PEG-40 hydrogenated castor
Oil 0.06 part, hyaluronate sodium 0.44 part, methyl hydroxybenzoate 0.4 part, Margarita powder 0.2 part, 2-bromo-2-nitropropane-1,3-glycol
0.16 part, disodiumedetate 0.16 part, Rosa centifolia L caul-fat 0.2 part, 299.248 parts of water.
The preparation method of the present embodiment whitening and speckle dispelling facial cream is with embodiment 1.
Clinical effectiveness is tested:
Patient data: 128 example patients, wherein male patient 3 example, female patient 125 example, age 32～52 years old, average year
In 36.5 years old age, patient all shows as face and large area chloasma occurs.
Therapeutic Method: face smears the facial cream of the embodiment of the present invention 1 preparation, the most once, using 28 days is a treatment
Journey, adds up the therapeutic effect of two courses for the treatment of.Meanwhile, during treating and after treatment, patient all should notice that guarding against anger guards against melancholy, keeps happy
See emotion, diet is avoided excessive pungent stimulation food, pay special attention to avoid abusing cosmetics.
Criterion of therapeutical effect: substantially cure: mottle area disappears > 90%, color disappears substantially；
Effective: mottle area disappears > 60%, color substantially shoals；
Take a turn for the better: mottle area disappears 30%, color is thin out；
Invalid disappearing≤30% for mottle area, color change is inconspicuous.
Effective percentage adds effective statistics with recovery from illness.
Therapeutic outcome: 128 example patients, after two course of therapy, 46 examples of fully recovering, effective 68 examples, take a turn for the better 13 examples, the most invalid
11 examples, effective percentage is 89%.All there is not obvious adverse reaction in all cases.
Model case: Song, female, 31 years old.On May 28th, 2014 goes to a doctor.Main suit's facial pigmented spots 2 years, 2 years front faces
Light brown speckle occur, rear scope flaring is big, and color is gradually deepened, and does not once write by western medicines in treatment effect.Readme abdominal pain during menstruation is irritated
Irritability, and companion's breast side of body is vexed swollen, weak digestive function of the spleen and stomach, menoxenia, premenstrual symptoms increases the weight of, distending pain of the breast.Have a medical check-up: near the eyes, can by the wing of nose
Seeing deep brown spot, edge is the most whole, and red tongue has ecchymosis, stringy and rolling pulse.Being diagnosed as chloasma, card belongs to congestion of the liver, implements to the present invention
Facial cream prepared by example, external, every day each 1 time sooner or later.Further consultation after 7 days, readme mood gets better, and sleep quality improves, energetic,
Follow-up continuous use facial cream of the present invention 56 days, recovery from illness.
Claims (7)
1. a whitening and speckle dispelling Chinese medicine composition, it is characterised in that be made up of the raw material of following parts by weight: Flos Tulipae Gesnerianae extract
2～4 parts, Radix Notoginseng extract 2～4 parts, Radix Rehmanniae Preparata extract 3～5 parts, Semen Persicae extract 5～7 parts, Radix Ophiopogonis extract 2～4 parts,
Rhizoma Cyperi extract 2～4 parts, Radix Bupleuri extract 2～4 parts, Rhizoma Atractylodis Macrocephalae extract 3～5 parts, Fructus Forsythiae berry extract 2～4 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae)
Root extract 3～5 parts, Radix Salviae Miltiorrhizae extract 2～4 parts, river Radix Paeoniae Rubra extract 5～7 parts, opoponax extract 3～5 parts, Poria carry
Take thing 2～4 parts, Flos Carthami extract 2～4 parts, licorice root extract 2.5～5.5 parts, Radix Angelicae Sinensis extract 2～4 parts.
2. whitening and speckle dispelling Chinese medicine composition as claimed in claim 1, it is characterised in that by the raw material group of following parts by weight
Become: Flos Tulipae Gesnerianae extract 3 parts, Radix Notoginseng extract 3 parts, Radix Rehmanniae Preparata extract 4 parts, 6 parts of Semen Persicae extract, Radix Ophiopogonis extract 3 parts,
Rhizoma Cyperi extract 3 parts, Radix Bupleuri extract 3 parts, Rhizoma Atractylodis Macrocephalae extract 4 parts, Fructus Forsythiae berry extract 3 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) root extract 4 parts,
Radix Salviae Miltiorrhizae extract 3 parts, river Radix Paeoniae Rubra extract 6 parts, opoponax extract 4 parts, Poria extract 3 parts, Flos Carthami extract 3 parts, sweet
Grass roots extract 3.6 parts, Radix Angelicae Sinensis extract 3 parts.
3. a whitening and speckle dispelling Chinese medicine preparation, it is characterised in that include whitening and speckle dispelling Chinese drug-treated group as claimed in claim 1 or 2
Adjuvant needed for compound, pharmaceutical preparation or cosmetic formulations preparation.
4. a whitening and speckle dispelling facial cream, it is characterised in that include whitening and speckle dispelling Chinese medicine composition as claimed in claim 1 or 2,
Adjuvant needed for facial cream preparation.
5. whitening and speckle dispelling facial cream as claimed in claim 4, it is characterised in that be prepared from by the raw material of following parts by weight:
Whitening and speckle dispelling Chinese medicine composition 60 as claimed in claim 1 or 2～63 parts, glycerol 20～25 parts, carbomer 4～6 parts, pool Lip river
Husky nurse 188 3.5～5.5 parts, propylene glycol 3～5 parts, sodium hydroxide 0.5～1 part, imidazolidinyl urea 0.5～1 part, cocoanut oil alcohol gather
-7 0.2～0.4 parts of ether, PPG-1-PEG-9 Laurel glycol ethers 0.05～0.2 part, Cremophor RH40 0.03～0.08
Part, hyaluronic acid 0.35～0.55 part, methyl hydroxybenzoate 0.3～0.5 part, Margarita powder 0.1～0.3 part, 2-bromo-2-nitropropane-
1,3-glycol 0.1～0.2 part, disodiumedetate 0.1～0.2 part, Rosa centifolia L caul-fat 0.1～0.3 part, water 295～305
Part.
6. whitening and speckle dispelling facial cream as claimed in claim 5, it is characterised in that be prepared from by the raw material of following parts by weight:
Whitening and speckle dispelling Chinese medicine composition 61.6 parts, glycerol 22 parts, carbomer 5.2 parts, PLURONICS F87 as claimed in claim 2
4.4 parts, propylene glycol 4 parts, sodium hydroxide 0.832 part, imidazolidinyl urea 0.8 part, coceth-7 0.3 parts, PPG-1-PEG-
9 Laurel glycol ethers 0.12 part, Cremophor RH40 0.06 part, hyaluronate sodium 0.44 part, methyl hydroxybenzoate 0.4 part, Margarita
0.2 part of powder, 2-bromo-2-nitropropane-1,3-glycol 0.16 part, disodiumedetate 0.16 part, Rosa centifolia L caul-fat 0.2
Part, 299.248 parts of water.
7. the preparation method of the whitening and speckle dispelling facial cream as described in claim 5 or 6, it is characterised in that include following operation
Step:
(1) take part water and add carbomer, after soaking 10～15 hours, carry out homogenizing and be completely dispersed to carbomer, add hydrogen-oxygen
Change sodium, mix homogeneously, obtain mixed material 1, standby；By PLURONICS F87, hyaluronate sodium, 2-bromine 2-nitropropane-1,3-two
Alcohol adds in remaining water, and mix homogeneously obtains mixed material 2, standby；Propylene glycol is added in methyl hydroxybenzoate, mix homogeneously,
Mixed material 3, standby；Take Rosa centifolia L caul-fat and add coceth-7, PPG-1-PEG-9 Laurel glycol ethers, PEG-40 hydrogenation
Oleum Ricini, mix homogeneously, obtain mixed material 4；
(2) mixed material 2 is added in mixed material 1, mix homogeneously, obtain mixed material 5；
(3) add Flos Tulipae Gesnerianae extract, Radix Notoginseng extract, Radix Rehmanniae Preparata extract, Semen Persicae extract, Radix Ophiopogonis in mixed material 5
Extract, Rhizoma Cyperi extract, Radix Bupleuri extract, Rhizoma Atractylodis Macrocephalae extract, Fructus Forsythiae berry extract, Pseudobulbus Bletillae (Rhizoma Bletillae) root extract, Radix Salviae Miltiorrhizae extract
Thing, river Radix Paeoniae Rubra extract, opoponax extract, Poria extract, Flos Carthami extract, licorice root extract, Radix Angelicae Sinensis extract, sweet
Oil, Margarita powder, imidazolidinyl urea, disodiumedetate, mix homogeneously, obtain mixed material 6；
(4) in mixed material 6, add mixed material 3, mix homogeneously, obtain mixed material 7；Mixing is added in mixed material 7
Material 4, mix homogeneously, obtain described clear paste.
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| CN106667853A (en) * | 2017-02-28 | 2017-05-17 | 广州诚予化妆品有限公司 | Facial mask with antiallergic repair function and production process thereof |
| CN107714556A (en) * | 2017-11-24 | 2018-02-23 | 储成玲 | A kind of face cream of resisting age of skin and preparation method thereof |
| CN108042443A (en) * | 2018-02-22 | 2018-05-18 | 西安年华生物科技有限公司 | A kind of essence cream for dispelling speckle and whitening and preparation method thereof |
| CN108143682A (en) * | 2018-01-10 | 2018-06-12 | 广州市聚吉科绿色化学共性技术研究院有限公司 | A kind of promoting blood circulation lightening compositions |
| CN109288737A (en) * | 2017-07-24 | 2019-02-01 | 云南云品科技有限公司 | A kind of cordyceps sinensis skin whitening, moisturizing face cream |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106667853A (en) * | 2017-02-28 | 2017-05-17 | 广州诚予化妆品有限公司 | Facial mask with antiallergic repair function and production process thereof |
| CN109288737A (en) * | 2017-07-24 | 2019-02-01 | 云南云品科技有限公司 | A kind of cordyceps sinensis skin whitening, moisturizing face cream |
| CN107714556A (en) * | 2017-11-24 | 2018-02-23 | 储成玲 | A kind of face cream of resisting age of skin and preparation method thereof |
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| CN108042443A (en) * | 2018-02-22 | 2018-05-18 | 西安年华生物科技有限公司 | A kind of essence cream for dispelling speckle and whitening and preparation method thereof |
| CN109718184A (en) * | 2019-03-12 | 2019-05-07 | 北温草生物科技(上海)有限公司 | A kind of combined extracts of plant whitening agent |
| CN110075052A (en) * | 2019-05-20 | 2019-08-02 | 重庆跃龙生物制药有限公司 | Whitening spot-removing, skin-protecting face nursing composition and its preparation method and application |
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| CN106109932B (en) | 2020-07-03 |
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Denomination of invention: Whitening and freckle-removing traditional Chinese medicine composition, whitening and freckle-removing traditional Chinese medicine preparation, whitening and freckle-removing facial cream, and preparation method Effective date of registration: 20220823 Granted publication date: 20200703 Pledgee: Laiwu Shandong rural commercial bank Limited by Share Ltd. Pledgor: SHANDONG HEBAO PHARMACEUTICAL Co.,Ltd. Registration number: Y2022980013361 |
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