CN104740321A - Traditional Chinese medicine composition for removing chloasma and preparation method thereof - Google Patents

Traditional Chinese medicine composition for removing chloasma and preparation method thereof Download PDF

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Publication number
CN104740321A
CN104740321A CN201510148419.6A CN201510148419A CN104740321A CN 104740321 A CN104740321 A CN 104740321A CN 201510148419 A CN201510148419 A CN 201510148419A CN 104740321 A CN104740321 A CN 104740321A
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parts
rhizoma
traditional chinese
skin
radix
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郭静
陈佳
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Teaching Hospital of Chengdu University of TCM
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Teaching Hospital of Chengdu University of TCM
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Abstract

The invention provides a traditional Chinese medicine composition for removing chloasma. The traditional Chinese medicine composition is a preparation prepared from the following raw pharmaceutical materials in parts by weight: 18-20 parts of angelica sinensis, 18-20 parts of peach kernels, 18-20 parts of Chuanxiong rhizome, 25-30 parts of salvia miltiorrhiza, 25-30 parts of Chinese yam rhizome, 12-15 parts of talcum, 18-20 parts of duckweed, 18-20 parts of white poria, 18-20 parts of atractylodes macrocephala, 18-20 parts of excrementum passeris, 18-20 parts of giant typhonium rhizome, 18-20 parts of white stiff silkworm, 18-20 parts of hyacinth bletilla, 18-20 parts of radix ampelopsis, 18-20 parts of dahurian angelica root, 12-15 parts of pearl powder and 25-30 parts of mung beans. The invention further provides a preparation method and use of the traditional Chinese medicine composition. According to the traditional Chinese medicine composition for removing chloasma, provided by the invention, the compatibility is precise and appropriate, and all medicines supplement each other, so that the traditional Chinese medicine composition has remarkable treatment effects on relieving the state of illness of patients suffering from chloasma and preventing recurrence; the traditional Chinese medicine composition for removing chloasma, provided by the invention, is safe in use and low in side effect and further has the effects of treating or relieving insomnia, anxiety, irritability and constipation symptoms, improving the menstruation condition, tendering and whitening skin, enhancing the lubricity and elasticity of skin, compacting skin, delaying skin aging, lightening and removing chloasma and cleaning skin black spots.

Description

A kind of freckle removal traditional Chinese medicinal composition and preparation method thereof
Technical field
The present invention relates to a kind of freckle removal traditional Chinese medicinal composition and preparation method thereof, belong to the field of Chinese medicines.
Background technology
Chloasma (Chloasma) is a kind of common facial pigmentation dermatoses, show as symmetry and betide face, especially the place such as two cheeks, forehead, nose is common, skin lesion is filbert, dark brown, light black patch, and the traditional Chinese medical science claims primary disease to be " chloasma ", " dusty face ", " butterfly spot " etc.This disease is more common in young and middle-aged women clinically, and it is a kind of dermatosis of damaging capacitive, and chloasma skin lesion itself seldom brings misery or discomfort to patient, but Yin Qichang betides face and affects appearance, to the spirit of patient with in lifely bring many worries and misery.
Chloasma is because dispelling difficulty, and course of disease stubbornness is called as " king of mottle ", and its cause of disease and pathogenesis are still not fully aware of so far.It has been generally acknowledged that, this disease is relevant to factors such as endocrine disturbance, heredity, ultraviolet radiation, oral contraceptive, cosmetics for external use, gestation.This disease of current western medical treatment adopts external treatment more, though there is certain effect, for a long time with producing certain toxic and side effects, as atrophoderma, pigment bounce-back etc.Oral conventional vitamin C and E, but curative effect still owes desirable.The treatment of the traditional Chinese medical science to chloasma is with a long history, and Chinese traditional treatment focuses on endocrine regulation, cures the disease and effect a permanent cure.At present with Chinese medicine for the traditional Chinese medicine freckle-removing product of theory becomes many day by day, but its preparation technology is numerous and diverse, and to using the specific aim of crowd and indefinite, consumer is caused blindly to be selected, skin of face as " experimental plot ", the phenomena of cutaneous irritation that frequent appearance is serious, freckle effect is unsatisfactory, and mottle even increases the weight of.Therefore, the focus that effective traditional Chinese medicine freckle-removing product becomes current medical circle, beauty treatment circle pays close attention to jointly is developed.
Summary of the invention
The object of the present invention is to provide a kind of freckle removal traditional Chinese medicinal composition and its production and use.
The invention provides a kind of freckle removal traditional Chinese medicinal composition, it is the preparation be prepared from by the crude drug containing following weight proportioning:
Radix Angelicae Sinensis 18-20 part, Semen Persicae 18-20 part, Rhizoma Chuanxiong 18-20 part, Radix Salviae Miltiorrhizae 25-30 part, Rhizoma dioscoreae 25-30 part, Talcum 12-15 part, Herba Spirodelae 18-20 part, Poria 18-20 part, Rhizoma Atractylodis Macrocephalae 18-20 part, Faeces Passeris 18-20 part, Rhizoma Typhonii 18-20 part, Bombyx Batryticatus 18-20 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 18-20 part, Radix Ampelopsis 18-20 part, Radix Angelicae Dahuricae 18-20 part, Margarita powder 12-15 part, Semen phaseoli radiati 25-30 part.
Further preferably, it is the preparation be prepared from by the crude drug of following weight proportioning:
Radix Angelicae Sinensis 18-20 part, Semen Persicae 18-20 part, Rhizoma Chuanxiong 18-20 part, Radix Salviae Miltiorrhizae 25-30 part, Rhizoma dioscoreae 25-30 part, Talcum 12-15 part, Herba Spirodelae 18-20 part, Poria 18-20 part, Rhizoma Atractylodis Macrocephalae 18-20 part, Faeces Passeris 18-20 part, Rhizoma Typhonii 18-20 part, Bombyx Batryticatus 18-20 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 18-20 part, Radix Ampelopsis 18-20 part, Radix Angelicae Dahuricae 18-20 part, Margarita powder 12-15 part, Semen phaseoli radiati 25-30 part.
Still more preferably, it is the preparation be prepared from by the crude drug of following weight proportioning:
Radix Angelicae Sinensis 20 parts, 20 parts, Semen Persicae, Rhizoma Chuanxiong 20 parts, Radix Salviae Miltiorrhizae 30 parts, Rhizoma dioscoreae 30 parts, 15 parts, Talcum, 20 parts, Herba Spirodelae, Poria 20 parts, the Rhizoma Atractylodis Macrocephalae 20 parts, Faeces Passeris 20 parts, Rhizoma Typhonii 20 parts, Bombyx Batryticatus 20 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 20 parts, Radix Ampelopsis 20 parts, the Radix Angelicae Dahuricae 20 parts, Margarita powder 15 parts, 30 parts, Semen phaseoli radiati.
The present composition is active component by the protogenic medicinal powder of Radix Angelicae Sinensis, Semen Persicae, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Rhizoma dioscoreae, Talcum, Herba Spirodelae, Poria, the Rhizoma Atractylodis Macrocephalae, Faeces Passeris, Rhizoma Typhonii, Bombyx Batryticatus, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Ampelopsis, the Radix Angelicae Dahuricae, Margarita powder, Semen phaseoli radiati or water or extractive with organic solvent, adds the external preparation that pharmaceutically acceptable adjuvant or complementary composition are prepared from.
Wherein, the dosage form of described external preparation is tincture, unguentum, gel, lotion, liniment, emulsion, membrane.
Wherein, described complementary composition comprises kojic acid, ursolic acid, vitamin E, vitamin E and derivant thereof or vitamin C.
Present invention also offers a kind of preparation method of described freckle removal traditional Chinese medicinal composition, it comprises the steps:
A, take the crude drug of each weight proportion;
B, beat powder, or to add water or organic solvent decocts and extracts, add the external preparation that pharmaceutically acceptable adjuvant or complementary composition are prepared from.
Described organic solvent is ethanol.
Present invention also offers described compositions and prepare the purposes in the medicine or cosmetics with spot-removal function.
Wherein, described medicine or cosmetics are medicine or cosmetics for the treatment of chloasma.
Present invention also offers the purposes of described compositions in preparation treatment or relieving insomnia, irritable, constipation symptom, the medicine improving menstruation or cosmetics.
Present invention also offers described compositions, in preparation, there is tender pale skin, increase skin lubrication and elasticity, the skin that compacts, delay skin aging, lightly move back brown patch, purposes in the medicine of removing skin blackhead effect or cosmetics.
Chloasma is how smooth by the liver failing to maintain the normal flow of QI, QI-blood circulation, can not be flourish caused by the skin; Or because of eating and drinking without temperance, impairment caused by overstrain is excessive, spleen loses transporting, and phlegm-damp stain causes raw brown patch in face; Or because of the hepatic and renal YIN deficiency, water thanks to can not fire processed, asthenic fire inflammation make face become raw brown patch.The merit of blood circulation promoting and blood stasis dispelling played altogether by Radix Angelicae Sinensis in medicine material prescription of the present invention, Semen Persicae, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, wherein Radix Angelicae Sinensis, Rhizoma Chuanxiong are the product that pungent temperature row is loose, not only can removing blood stasis and activating blood flow, compatibility Bombyx Batryticatus, Radix Ampelopsis, Rhizoma Typhonii also can dissipate phlegm-damp cohesion, and Semen Persicae, Radix Salviae Miltiorrhizae bitter in the mouth are flat, and both in the side of avoiding, pungent using warming therapy product excessively consumed impairment of YIN blood, simultaneously again can promoting tissue regeneration by removing blood stasis, accelerate the metabolism of ecchymosis part, Compendium of Material Medica evaluates Radix Salviae Miltiorrhizae: " can break stagnated blood, mend fresh blood ".Rhizoma Typhonii, Bombyx Batryticatus, Radix Ampelopsis, the Radix Angelicae Dahuricae can drying dampness to eliminate phlegm eliminating stagnation, jointly eliminates the paathogenic factor of chloasma phlegm and blood stasis with above-mentioned blood circulation promoting medicine." the spleen being the source of producing phlegm ", Rhizoma Dioscoreae, Poria, Rhizoma Atractylodis Macrocephalae invigorating spleen to remove dampness reduce phlegm, simultaneously Rhizoma Dioscoreae energy " antidiarrheal is sharp, and reduce phlegm saliva for kidney tonifying gas, strengthening the spleen and stomach ", and compatible with Faeces Passeris, both play the merit of warming the kidney and strengthening the spleen altogether, can remove morbidity basic from pathogenesis.In side, the contained Pseudobulbus Bletillae (Rhizoma Bletillae), the Radix Angelicae Dahuricae, Radix Ampelopsis, Bombyx Batryticatus, Rhizoma Typhonii, Faeces Passeris, Poria are that seven basic pharmaceutical faling apart side in vain form, be good at dispel turbid stagnant, black speck on treatment face, for the classical side of Whitening, spot: Radix Angelicae Dahuricae energy longue skin, moist color, " drive the wind of skin migration ", Poria has except Shao-goes out the effect of scar, the Pseudobulbus Bletillae (Rhizoma Bletillae) nourishes skin, and make us flesh and slide, Faeces Passeris has the effect of eliminate indigestion removing nebula, " freckle on face can be removed ", Bombyx Batryticatus, Rhizoma Typhonii have dispelling pathogenic wind and eliminating phlegm effect, and retardance is circulated, and stagnate and can drain.In side, Herba Spirodelae returns lung meridian, walks table, the product that the heat clearing away such as compatibility Talcum, Semen phaseoli radiati, Margarita powder are brisk and neat, can eliminate pent-up in the dryness-fire pyretic toxicity of skin, in addition, Margarita powder quality is greasy in vain, inherently there is the merit of " moistening skin and eliminating spot ", make former side on the basis of light speckle, have more the merit of whitening.
Freckle removal traditional Chinese medicinal composition compatibility provided by the invention is precise and appropriate, and each flavour of a drug complement each other, and to the alleviation patient with chloasma state of an illness, prevents recurrence evident in efficacy, all effective to each pattern of syndrome of the chloasma traditional Chinese medical science.And freckle removal traditional Chinese medicinal composition use safety of the present invention, side effect is little, also has treatment or relieving insomnia, irritable, constipation, improves menstruation; Tender pale skin, increases skin lubrication and elasticity, the skin that compacts, delay skin aging, the light effect of moving back brown patch, removing skin blackhead.
Detailed description of the invention
Be described further with embodiment below, but the present invention is not limited to these embodiments.
The preparation of embodiment 1 freckle removal traditional Chinese medicinal composition of the present invention
Take each weight crude drug: Radix Angelicae Sinensis 20g, Semen Persicae 20g, Rhizoma Chuanxiong 20g, Radix Salviae Miltiorrhizae 30g, Rhizoma dioscoreae 30g, Talcum 15g, Herba Spirodelae 20g, Poria 20g, Rhizoma Atractylodis Macrocephalae 20g, Faeces Passeris 20g, Rhizoma Typhonii 20g, Bombyx Batryticatus 20g, Pseudobulbus Bletillae (Rhizoma Bletillae) 20g, Radix Ampelopsis 20g, Radix Angelicae Dahuricae 20g, Margarita powder 15g, Semen phaseoli radiati 30g.
Preparation method:
Each Chinese medicine ingredients takes according to above-mentioned weight proportion, pulverizing, and after pulverizing, size controlling is at 50-90um, adds clear water or Lac Bovis seu Bubali or Ovum Gallus domesticus album and stirs evenly, then adds Mel and mix well.
Using method:
The above-mentioned medicine prepared evenly is smeared on the face, after about 20 minutes, then rinse well with clear water, after face is cleaned, olive oil is picked by cotton pads, spread on the face, about 5 minutes, and then cover on the face with hot towel, now cotton pads does not need to take away, after towel cooling, then towel and cotton pads are taken off, clean face.
The dosage form preparation of embodiment 2 freckle removal traditional Chinese medicinal composition of the present invention
The simple dosage form preparation of A, extract
Take the crude drug of each weight proportion: Radix Angelicae Sinensis 18g, Semen Persicae 18g, Rhizoma Chuanxiong 18g, Radix Salviae Miltiorrhizae 25g, Rhizoma dioscoreae 25g, Talcum 12g, Herba Spirodelae 18g, Poria 18g, Rhizoma Atractylodis Macrocephalae 18g, Faeces Passeris 18g, Rhizoma Typhonii 18g, Bombyx Batryticatus 18g, Pseudobulbus Bletillae (Rhizoma Bletillae) 18g, Radix Ampelopsis 18g, Radix Angelicae Dahuricae 18g, Margarita powder 12g, Semen phaseoli radiati 25g.
Preparation method:
Each Chinese medicine ingredients takes according to above-mentioned weight proportion, and adopt water or ethanol extraction to obtain extract after pulverizing, dry, again pulverize, powder particle diameter controls at 50-90um, can obtain active raw materials medicine.After active component pulverizing, add pure water 500ml or Lac Bovis seu Bubali 500ml or Ovum Gallus domesticus album 500ml and stir evenly, then add Mel and mix well.
Using method:
The above-mentioned medicaments uniformity prepared is smeared on the face, after about 20 minutes, then rinse well with clear water, after face is cleaned, olive oil is picked by cotton pads, spread on the face, about 5 minutes, and then cover on the face with hot towel, now cotton pads does not need to take away, after towel cooling, then towel and cotton pads are taken off, clean face.
Prepared by B, extract ointment dosage form
Take the raw material of each weight proportion:
Radix Angelicae Sinensis 20g, Semen Persicae 20g, Rhizoma Chuanxiong 20g, Radix Salviae Miltiorrhizae 30g, Rhizoma dioscoreae 30g, Talcum 15g, Herba Spirodelae 20g, Poria 20g, Rhizoma Atractylodis Macrocephalae 20g, Faeces Passeris 20g, Rhizoma Typhonii 20g, Bombyx Batryticatus 20g, Pseudobulbus Bletillae (Rhizoma Bletillae) 20g, Radix Ampelopsis 20g, Radix Angelicae Dahuricae 20g, Margarita powder 15g, Semen phaseoli radiati 30g.
Preparation method:
(1) using human body acceptable adjunct ingredient glycerol 60g, stearic acid 90g, triethanolamine 30g, liquid Paraffin 100g, paraffin 70g, ethyl hydroxybenzoate 10g, pure water 400ml as adjuvant, after heating and melting, stir and condensation, can ointment bases be obtained.
(2) each Chinese medicine ingredients taken according to above-mentioned weight proportion, adopt water or ethanol extraction to obtain extract after pulverizing, dry, again pulverize, powder particle diameter controls at 50-90um, can obtain active raw materials medicine.
(3) crude drug that (2) obtain is added in the substrate of (1) gained and stir, namely can be made into ointment formulation.
Prepared by C, extract cream form
Take the raw material of each weight proportion:: Radix Angelicae Sinensis 20g, Semen Persicae 20g, Rhizoma Chuanxiong 20g, Radix Salviae Miltiorrhizae 30g, Rhizoma dioscoreae 30g, Talcum 15g, Herba Spirodelae 20g, Poria 20g, Rhizoma Atractylodis Macrocephalae 20g, Faeces Passeris 20g, Rhizoma Typhonii 20g, Bombyx Batryticatus 20g, Pseudobulbus Bletillae (Rhizoma Bletillae) 20g, Radix Ampelopsis 20g, Radix Angelicae Dahuricae 20g, Margarita powder 15g, Semen phaseoli radiati 30g.
Preparation method:
(1) polyacrylic acid 50g, triethanolamine 5g, disodiumedetate 2g, propylene glycol 200g, benzoic acid 2g, pure water 500ml are placed in container, heat fused, stir and condensation, obtain cream base;
(2) take according to above-mentioned weight proportion as each Chinese medicine ingredients of adjuvant, adopt water or ethanol extraction to obtain extract after pulverizing, dry, again pulverize, powder particle diameter controls at 50-90um, can obtain active raw materials medicine.
(3) (2) are joined in (1) fully stir, can cream preparation be prepared.
Prepared by D, extract liniment
Take the raw material of each weight proportion: Radix Angelicae Sinensis 20g, Semen Persicae 20g, Rhizoma Chuanxiong 20g, Radix Salviae Miltiorrhizae 30g, Rhizoma dioscoreae 30g, Talcum 15g, Herba Spirodelae 20g, Poria 20g, Rhizoma Atractylodis Macrocephalae 20g, Faeces Passeris 20g, Rhizoma Typhonii 20g, Bombyx Batryticatus 20g, Pseudobulbus Bletillae (Rhizoma Bletillae) 20g, Radix Ampelopsis 20g, Radix Angelicae Dahuricae 20g, Margarita powder 15g, Semen phaseoli radiati 30g.
Preparation method:
(1) ethanol 200ml (95%), phenol 20g, boric acid 50g, pure water 500ml are placed in container, heating for dissolving, cool after stirring, namely can be used as disinfectant adjuvant;
(2) each Chinese medicine ingredients takes according to above-mentioned weight proportion, and adopt water or ethanol extraction to obtain extract after pulverizing, dry, again pulverize, powder particle diameter controls at 50-90um, can obtain active raw materials medicine.
(3) (2) are joined in (1) stir, the whitening and speckle dispelling liniment with sterilizing function can be obtained.
Prepared by E, extract tincture
Take the raw material of each weight proportion:
Radix Angelicae Sinensis 20g, Semen Persicae 20g, Rhizoma Chuanxiong 20g, Radix Salviae Miltiorrhizae 30g, Rhizoma dioscoreae 30g, Talcum 15g, Herba Spirodelae 20g, Poria 20g, Rhizoma Atractylodis Macrocephalae 20g, Faeces Passeris 20g, Rhizoma Typhonii 20g, Bombyx Batryticatus 20g, Pseudobulbus Bletillae (Rhizoma Bletillae) 20g, Radix Ampelopsis 20g, Radix Angelicae Dahuricae 20g, Margarita powder 15g, Semen phaseoli radiati 30g.
(1) each Chinese medicine ingredients takes according to above-mentioned weight proportion, and adopt water or ethanol extraction to obtain extract after pulverizing, dry, again pulverize, powder particle diameter controls at 50-90um, can obtain active raw materials medicine.
(2) (1) is slowly added in 300ml ethanol (95%), stir, tincture dosage form can be prepared.
Prepared by the combination dosage forms of embodiment 3 freckle removal traditional Chinese medicinal composition of the present invention and other whitening monomeric compounds
Take the raw material of each weight proportion:
Radix Angelicae Sinensis 20g, Semen Persicae 20g, Rhizoma Chuanxiong 20g, Radix Salviae Miltiorrhizae 30g, Rhizoma dioscoreae 30g, Talcum 15g, Herba Spirodelae 20g, Poria 20g, Rhizoma Atractylodis Macrocephalae 20g, Faeces Passeris 20g, Rhizoma Typhonii 20g, Bombyx Batryticatus 20g, Pseudobulbus Bletillae (Rhizoma Bletillae) 20g, Radix Ampelopsis 20g, Radix Angelicae Dahuricae 20g, Margarita powder 15g, Semen phaseoli radiati 30g.
Preparation method:
Each Chinese medicine ingredients takes according to above-mentioned weight proportion, and adopt water or ethanol extraction to obtain extract after pulverizing, dry, again pulverize, powder particle diameter controls at 50-90um, can obtain active raw materials medicine.
After active component pulverizing, add pure water 500ml heating for dissolving even, add arbutin (total amount is no more than 7% of extract total amount) subsequently, or add kojic acid (total amount accounts for 05%-2% of extract total amount), stir, whitening combination preparation can be obtained.
Embodiment 4 freckle removal traditional Chinese medicinal composition of the present invention and other whitening monomeric compounds combine can prepare multiple dosage form
Each Chinese medicine ingredients takes according to following weight proportioning: Radix Angelicae Sinensis 20g, Semen Persicae 20g, Rhizoma Chuanxiong 20g, Radix Salviae Miltiorrhizae 30g, Rhizoma dioscoreae 30g, Talcum 15g, Herba Spirodelae 20g, Poria 20g, Rhizoma Atractylodis Macrocephalae 20g, Faeces Passeris 20g, Rhizoma Typhonii 20g, Bombyx Batryticatus 20g, Pseudobulbus Bletillae (Rhizoma Bletillae) 20g, Radix Ampelopsis 20g, Radix Angelicae Dahuricae 20g, Margarita powder 15g, Semen phaseoli radiati 30g.Adopt water or ethanol extraction to obtain extract after pulverizing, dry, again pulverize, powder particle diameter controls at 50-90um, can obtain active raw materials medicine.
Above-mentioned raw materials powder, adopt multiple dosage form preparation method in embodiment 2, arbutin (total amount is no more than 7% of extract total amount) is added in mixed process, or add kojic acid (total amount accounts for 05%-2% of extract total amount), stir, can obtain having the combined ointment of whitening and speckle dispelling, ointment, liniment and tincture.
Using method:
The above-mentioned medicaments uniformity prepared is smeared on the face, after about 20 minutes, then rinse well with clear water, after face is cleaned, olive oil is picked by cotton pads, spread on the face, about 5 minutes, and then cover on the face with hot towel, now cotton pads does not need to take away, after towel cooling, then towel and cotton pads are taken off, clean face.
The preparation of embodiment 5 freckle-removing mask of the present invention
Preparation method 1:
Each Chinese medicine ingredients takes according to following weight proportioning: Radix Angelicae Sinensis 20g, Semen Persicae 20g, Rhizoma Chuanxiong 20g, Radix Salviae Miltiorrhizae 30g, Rhizoma dioscoreae 30g, Talcum 15g, Herba Spirodelae 20g, Poria 20g, Rhizoma Atractylodis Macrocephalae 20g, Faeces Passeris 20g, Rhizoma Typhonii 20g, Bombyx Batryticatus 20g, Pseudobulbus Bletillae (Rhizoma Bletillae) 20g, Radix Ampelopsis 20g, Radix Angelicae Dahuricae 20g, Margarita powder 15g, Semen phaseoli radiati 30g, water or ethanol extraction is adopted to obtain extract after pulverizing, dry, again pulverize, powder particle diameter controls at 50-90um, can obtain active raw materials medicine.
Above-mentioned raw materials powder, adds pure water 400ml or Lac Bovis seu Bubali (400ml) or Yoghourt 400ml or Ovum Gallus domesticus album 400ml and stirs evenly, then adds Mel and mix well, and prepares whitening and speckle dispelling raw material medicinal liquid.Take out the face paper purchased, be placed in raw material medicinal liquid and soak completely (20min), taking-up can obtain freckle-removing mask.
Preparation method 2:
Each Chinese medicine ingredients takes according to following weight proportioning: Radix Angelicae Sinensis 20g, Semen Persicae 20g, Rhizoma Chuanxiong 20g, Radix Salviae Miltiorrhizae 30g, Rhizoma dioscoreae 30g, Talcum 15g, Herba Spirodelae 20g, Poria 20g, Rhizoma Atractylodis Macrocephalae 20g, Faeces Passeris 20g, Rhizoma Typhonii 20g, Bombyx Batryticatus 20g, Pseudobulbus Bletillae (Rhizoma Bletillae) 20g, Radix Ampelopsis 20g, Radix Angelicae Dahuricae 20g, Margarita powder 15g, Semen phaseoli radiati 30g.Adopt water or ethanol extraction to obtain extract after pulverizing, dry, again pulverize, powder particle diameter controls at 50-90um, can obtain active raw materials medicine.
Above-mentioned raw materials powder, adds pure water 400ml or Lac Bovis seu Bubali (400ml) or Yoghourt 400ml or Ovum Gallus domesticus album 400ml and stirs evenly, then adds Mel or a small amount of flour is mixed well to pasty state, can prepare whitening and speckle dispelling raw material medicinal liquid.Can for being directly applied in face.
Preparation method 3:
Each Chinese medicine ingredients takes according to following weight proportioning: Radix Angelicae Sinensis 20g, Semen Persicae 20g, Rhizoma Chuanxiong 20g, Radix Salviae Miltiorrhizae 30g, Rhizoma dioscoreae 30g, Talcum 15g, Herba Spirodelae 20g, Poria 20g, Rhizoma Atractylodis Macrocephalae 20g, Faeces Passeris 20g, Rhizoma Typhonii 20g, Bombyx Batryticatus 20g, Pseudobulbus Bletillae (Rhizoma Bletillae) 20g, Radix Ampelopsis 20g, Radix Angelicae Dahuricae 20g, Margarita powder 15g, Semen phaseoli radiati 30g.Adopt water or ethanol extraction to obtain extract after pulverizing, dry, again pulverize, powder particle diameter controls at 50-90um, can obtain active raw materials medicine.
Above-mentioned raw materials powder, adds pure water 400ml or Lac Bovis seu Bubali (400ml) or Yoghourt 400ml or Ovum Gallus domesticus album 400ml and stirs evenly, and instillation 2-3 drips natural Vitamin E, or adds appropriate Fructus Citri Limoniae juice, can prepare whitening and speckle dispelling raw material.Take out the face paper purchased, be placed in raw material medicinal liquid and soak completely (20min), taking-up can be enhanced type facial masks for whitening faces and removing spots.
Using method:
Above-mentioned facial film is evenly launched, or is applied on the face, after about 20 minutes, rinse well with clear water again, face picks olive oil by cotton pads, spreads on the face after cleaning, about 5 minutes, and then cover on the face with hot towel, now cotton pads does not need to take away, after waiting towel to cool, again towel and cotton pads are taken off, clean face.
Beneficial effect of the present invention is illustrated below by way of test example.
The clinical observation of test example 1 freckle-removing mask treatment of the present invention chloasma
(1) patient criteria's (or diagnostic criteria) is accepted for medical treatment
Gender and the range of age: patient 120 example, 20 ~ 50 years old age, women 110 example, male 10 example, total course of disease the shortest half a year, the longest 25 years, treatment time in the shortest January, the longest half a year.
Diagnostic criteria: chloasma diagnosis organizes the related standards in " clinical diagnosis of chloasma and curative effect determinate standard revised draft in 2003 " formulation of in December, 2003 formulation with reference to Dermatology Professional Committee of CAIM (Chinese Association Of Integrative Medicine) pigment disease: 1. facial filbert to dark brown, well-defined speckle sheet, usual symmetry distribution, after 3. 2. NIP performance and fish scale mainly occur in adolescence without obvious subjective symptoms, the multiple 4. state of an illness of women has certain seasonality, 5. the summer sowing winter gently gets rid of other diseases (as naevus fuscocaerules zygomaticus, melanosis, pigmentosa actinic lichen planus) pigmentation that causes.
The places such as the traditional Chinese medical science (or doctor trained in Western medicine) symptom feature: symmetry betides face, especially two cheeks, forehead, nose are common, and skin lesion is filbert, dark brown, light black patch, differs in size, different, clear border, no conscious sympton, Exposure to Sunlight postemphasis.
Diagnosis: chloasma
(2) standard is treated
The related standards organized with reference to Dermatology Professional Committee of CAIM (Chinese Association Of Integrative Medicine) pigment disease in " clinical diagnosis of chloasma and the curative effect determinate standard revised draft in 2003 " of in December, 2003 formulation is drafted.
Basic healing: naked eyes to disappear > 90% depending on mottle area, and skin lesion color disappears for normal skin tone substantially, and patient's insomnia, irritable, constipation, menstruation etc. are clearly better;
Effective: naked eyes to disappear > 60% depending on mottle area, and skin lesion color is obviously thin out is filbert, the improvements such as patient's insomnia, irritable, constipation, menstruation;
Effective: naked eyes to disappear > 30% depending on mottle area, and skin lesion color is thin out is brown, and patient's insomnia, irritable, constipation, menstruation etc. take a turn for the better to some extent;
Invalid: naked eyes to disappear > 30% depending on mottle area, the change of skin lesion color is not obvious be dark brown, the improvement of the nothing such as patient's insomnia, irritable, constipation, menstruation.
(3) Therapeutic Method
1, medication:
After clarifying a diagnosis, 120 routine patients all adopt following medicine: Radix Angelicae Sinensis 20g, Semen Persicae 20g, Rhizoma Chuanxiong 20g, Radix Salviae Miltiorrhizae 30g, Rhizoma dioscoreae 30g, Talcum 15g, Herba Spirodelae 20g, Poria 20g, Rhizoma Atractylodis Macrocephalae 20g, Faeces Passeris 20g, Rhizoma Typhonii 20g, Bombyx Batryticatus 20g, Pseudobulbus Bletillae (Rhizoma Bletillae) 20g, Radix Ampelopsis 20g, Radix Angelicae Dahuricae 20g, Margarita powder 15g, Semen phaseoli radiati 30g.
2 times weekly, each Chinese medicine composition gross weight 360g, after getting Chinese medicine composition (360g) pulverizing, adding clear water or Lac Bovis seu Bubali or Ovum Gallus domesticus album to stir evenly, then add Mel and mix well and evenly spread on face, is for 12 times a course for the treatment of, be used in conjunction 2 courses for the treatment of, treatments period, be not furnished with other Western medicine and other therapies.
Treatments period diet is light, avoids delicious food savoury, avoids sweet food, seafood food and hot fruit, avoids tobacco and wine, advise polyphagia vegetable.
2, without obvious medication taboo, insensitivity skin person.
(4) therapeutic outcome
Treatment time: 12 weeks
Efficacy determination: result is as follows
The curative effect of the routine patient of table 1 120 after treatment in 12 weeks
Therapeutic outcome Case load (example) Effective percentage (%)
Recovery from illness 20 16.66
Effective 18 15.00
Effectively 62 51.66
Invalid 20 16.66
Amount to 120 83.40
After treatment in 12 weeks, in 120 routine patients, recovery from illness 20 example, effective 18 examples, effective 62 examples, invalid 20 examples, total effective rate reaches 83.4%.
Untoward reaction: have no untoward reaction during medication, the accidental some patients treatment initial stage is micro-has skin to itch, and after adjustment medicament, is eased, controls.Some patients have a blood test resemble, hepatic and renal function is without exception.
As seen from the experiment, patient with chloasma all has no adverse reaction, without rebound phenomenon.Freckle-removing mask of the present invention is evident in efficacy to the alleviation patient with chloasma state of an illness.
Clinical observation shows freckle-removing mask of the present invention to be had and improves local skin blood capillary microcirculation, increase capillary permeability, enhance metabolism, activating skin cell, open pore, skin desired nutritional material and active Chinese drug component antioxidant content is made to penetrate to the skin depths fast, combine with the reticular connective tissue of Skin Cell, the effective blood circulation promoting and blood stasis dispelling of energy, repair, activated cell is active, pin moisture, increase skin elasticity, remove skin harmful substance, dispel skin aging cutin, toxic removing, supplement nutrient needed for skin, mineral etc., thus reach tender pale skin, increase skin lubrication and elasticity, compact skin, delay skin aging, lightly move back brown patch, remove the effects such as skin blackhead.
(5) model case
Patient Zhang, women, 28 years old.Because there are two buccal dark brown patches, dim complexion, usually menoxenia in patient, hydroquinone cream (detailed directions is not quite clear) is invalid in vain for oral administration vitamin C and outer painting thousand after Long-term Oral contraceptive.Recently the conscious part spot color of patient is deepened, patch increases, and quarter examines: two buccal speckle color depths are brown, dim complexion, irritable, menoxenia, premenstrual distending pain of the breast, difference of sleeping receive can, xerostomia tending to drink water is not understood, two just can, red tongue, thin fur, stringy pulse.Be stagnation of liver-qi type chloasma after diagnosing.Control suitable depressed liver-energy dispersing and QI regulating, the silt that disappears of invigorating blood circulation.Use specific embodiment of the invention method, 2 times weekly; And advise that patient keeps happy, avoid sunlight exposure, contraceptive of stopping using, regularity living, be cautious use of cosmetics excitatory, diet is light.By above-mentioned treatment 1 course for the treatment of, skin lesion color is obviously thin out, and skin lesion reduces; Again after medication 1 course for the treatment of, skin lesion color is normal skin tone.

Claims (10)

1. a freckle removal traditional Chinese medicinal composition, is characterized in that: it is the preparation be prepared from by the crude drug containing following weight proportioning:
Radix Angelicae Sinensis 18-20 part, Semen Persicae 18-20 part, Rhizoma Chuanxiong 18-20 part, Radix Salviae Miltiorrhizae 25-30 part, Rhizoma dioscoreae 25-30 part, Talcum 12-15 part, Herba Spirodelae 18-20 part, Poria 18-20 part, Rhizoma Atractylodis Macrocephalae 18-20 part, Faeces Passeris 18-20 part, Rhizoma Typhonii 18-20 part, Bombyx Batryticatus 18-20 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 18-20 part, Radix Ampelopsis 18-20 part, Radix Angelicae Dahuricae 18-20 part, Margarita powder 12-15 part, Semen phaseoli radiati 25-30 part.
2. freckle removal traditional Chinese medicinal composition according to claim 1, is characterized in that: it is the preparation be prepared from by the crude drug of following weight proportioning:
Radix Angelicae Sinensis 18-20 part, Semen Persicae 18-20 part, Rhizoma Chuanxiong 18-20 part, Radix Salviae Miltiorrhizae 25-30 part, Rhizoma dioscoreae 25-30 part, Talcum 12-15 part, Herba Spirodelae 18-20 part, Poria 18-20 part, Rhizoma Atractylodis Macrocephalae 18-20 part, Faeces Passeris 18-20 part, Rhizoma Typhonii 18-20 part, Bombyx Batryticatus 18-20 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 18-20 part, Radix Ampelopsis 18-20 part, Radix Angelicae Dahuricae 18-20 part, Margarita powder 12-15 part, Semen phaseoli radiati 25-30 part.
3. freckle removal traditional Chinese medicinal composition according to claim 2, is characterized in that: it is the preparation be prepared from by the crude drug of following weight proportioning:
Radix Angelicae Sinensis 20 parts, 20 parts, Semen Persicae, Rhizoma Chuanxiong 20 parts, Radix Salviae Miltiorrhizae 30 parts, Rhizoma dioscoreae 30 parts, 15 parts, Talcum, 20 parts, Herba Spirodelae, Poria 20 parts, the Rhizoma Atractylodis Macrocephalae 20 parts, Faeces Passeris 20 parts, Rhizoma Typhonii 20 parts, Bombyx Batryticatus 20 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 20 parts, Radix Ampelopsis 20 parts, the Radix Angelicae Dahuricae 20 parts, Margarita powder 15 parts, 30 parts, Semen phaseoli radiati.
4. the freckle removal traditional Chinese medicinal composition according to claim 1-3 any one, it is characterized in that: it is active component by the protogenic medicinal powder of Radix Angelicae Sinensis, Semen Persicae, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Rhizoma dioscoreae, Talcum, Herba Spirodelae, Poria, the Rhizoma Atractylodis Macrocephalae, Faeces Passeris, Rhizoma Typhonii, Bombyx Batryticatus, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Ampelopsis, the Radix Angelicae Dahuricae, Margarita powder, Semen phaseoli radiati or water or extractive with organic solvent, add the external preparation that pharmaceutically acceptable adjuvant or complementary composition are prepared from.
5. freckle removal traditional Chinese medicinal composition according to claim 4, is characterized in that: the dosage form of described external preparation is tincture, unguentum, gel, lotion, liniment, emulsion, membrane.
6. freckle removal traditional Chinese medicinal composition according to claim 4, is characterized in that: described complementary composition comprises kojic acid, ursolic acid, vitamin E, vitamin E and derivant thereof or vitamin C.
7. the preparation method of the freckle removal traditional Chinese medicinal composition described in claim 1 ~ 6 any one, it comprises the steps:
A, take the crude drug of each weight proportion;
B, beat powder, or to add water or organic solvent decocts and extracts, add the external preparation that pharmaceutically acceptable adjuvant or complementary composition are prepared from.
8. compositions described in claim 1 ~ 6 any one is preparing the purposes in the medicine or cosmetics with spot-removal function.
9. purposes according to claim 8, is characterized in that: described medicine or cosmetics are medicine or the cosmetics for the treatment of chloasma.
10. compositions described in claim 1 ~ 6 any one is being prepared treatment or relieving insomnia, irritable, constipation symptom, is being improved menstruation; Tender pale skin, increases skin lubrication and elasticity, the skin that compacts, delay skin aging, lightly move back brown patch, purposes in the medicine of removing skin blackhead effect or cosmetics.
CN201510148419.6A 2015-03-31 2015-03-31 Traditional Chinese medicine composition for removing chloasma and preparation method thereof Pending CN104740321A (en)

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CN105641352A (en) * 2016-03-06 2016-06-08 陈红 Medicinal preparation for treating facial stain and application thereof
CN105708979A (en) * 2016-03-10 2016-06-29 姚旺东 Traditional Chinese medicine composition capable of removing chloasma
CN105796457A (en) * 2016-03-11 2016-07-27 皖南医学院 Scar and pockmark removing lotion rich in natural extracts and preparation method of lotion
CN105963467A (en) * 2016-06-30 2016-09-28 冯袖幅 Traditional Chinese medicine composition, application thereof and preparation
CN106937934A (en) * 2015-12-29 2017-07-11 印骏 A kind of herbal composite and its preparation method for whitening spot-removing
CN107854631A (en) * 2017-10-26 2018-03-30 山东中医药高等专科学校 A kind of anti-ageing skin care compositions of whitening and its processing method
DK201600669A1 (en) * 2016-10-31 2018-05-28 Langear Tech Co Ltd Facial mask compositions
CN110123966A (en) * 2019-04-19 2019-08-16 周军臣 A kind of external application nti-freckle patch and preparation method thereof for beauty
CN112869160A (en) * 2021-02-04 2021-06-01 建昌帮药业有限公司 Freckle removing composition containing folic acid and preparation method thereof

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Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106937934A (en) * 2015-12-29 2017-07-11 印骏 A kind of herbal composite and its preparation method for whitening spot-removing
CN105641352A (en) * 2016-03-06 2016-06-08 陈红 Medicinal preparation for treating facial stain and application thereof
CN105708979A (en) * 2016-03-10 2016-06-29 姚旺东 Traditional Chinese medicine composition capable of removing chloasma
CN105796457A (en) * 2016-03-11 2016-07-27 皖南医学院 Scar and pockmark removing lotion rich in natural extracts and preparation method of lotion
CN105796457B (en) * 2016-03-11 2018-08-14 皖南医学院 A kind of scar anti-acne print lotion and preparation method thereof of dispelling rich in natural extract
CN105963467A (en) * 2016-06-30 2016-09-28 冯袖幅 Traditional Chinese medicine composition, application thereof and preparation
DK201600669A1 (en) * 2016-10-31 2018-05-28 Langear Tech Co Ltd Facial mask compositions
CN107854631A (en) * 2017-10-26 2018-03-30 山东中医药高等专科学校 A kind of anti-ageing skin care compositions of whitening and its processing method
CN110123966A (en) * 2019-04-19 2019-08-16 周军臣 A kind of external application nti-freckle patch and preparation method thereof for beauty
CN112869160A (en) * 2021-02-04 2021-06-01 建昌帮药业有限公司 Freckle removing composition containing folic acid and preparation method thereof

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