CN104740321A - Traditional Chinese medicine composition for removing chloasma and preparation method thereof - Google Patents

Abstract

The invention provides a traditional Chinese medicine composition for removing freckles, which is a preparation prepared from raw materials containing the following weight proportions: 18-20 parts of angelica, 18-20 parts of peach kernel, 18-20 parts of Chuanxiong, 25-25 parts of salvia miltiorrhiza 30 parts, 25-30 parts of Chinese yam, 12-15 parts of talc, 18-20 parts of duckweed, 18-20 parts of white poria cocos, 18-20 parts of Atractylodes macrocephala, 18-20 parts of white clove, 18-20 parts of white aconite, 18-20 parts of white silkworm, 18-20 parts of bletilla striata, 18-20 parts of bletilla striata, 18-20 parts of angelica dahurica, 12-15 parts of pearl powder, and 25-30 parts of mung beans. The invention also provides the preparation method and application of the pharmaceutical composition. The traditional Chinese medicine composition for removing freckles of the invention has precise compatibility, and the flavors of the medicines complement each other, and has remarkable curative effect on alleviating the condition of patients with chloasma and preventing recurrence. Moreover, the freckle removing traditional Chinese medicine composition of the present invention is safe to use, has few side effects, and can also treat or relieve symptoms of insomnia, irritability, constipation, and improve menstruation; whiten the skin, increase skin lubrication and elasticity, firm the skin, delay skin aging, lighten the skin The effect of reducing brown spots and clearing skin blackheads.

Description

A kind of anti-freckle traditional Chinese medicine composition and preparation method thereof

technical field

The invention relates to a traditional Chinese medicine composition for removing freckles and a preparation method thereof, belonging to the field of traditional Chinese medicines.

Background technique

Chloasma (Chloasma) is a common facial pigmentation skin disease. It is manifested as symmetrically occurring on the face, especially on the cheeks, forehead, and nose. The skin lesions are light brown, dark brown, and light black. Spots, traditional Chinese medicine called the disease as "spots", "face dust", "butterfly spots" and so on. Clinically, this disease is more common in young and middle-aged women. It is a skin disease that damages the appearance. Melasma skin lesions themselves rarely bring pain or discomfort to patients, but because they often occur on the face and affect their appearance, it is a serious problem for patients. It brings a lot of troubles and pains in the spirit and life.

Chloasma is known as the "King of Pigmentation" because of its difficulty in getting rid of and its stubborn course of disease. Its etiology and pathogenesis are still unclear. It is generally believed that the disease is related to many factors such as endocrine disorders, heredity, ultraviolet radiation, oral contraceptives, cosmetics for external use, and pregnancy. At present, Western medicine mostly adopts external treatment for this disease. Although it has a certain effect, it will produce certain toxic and side effects after long-term use, such as skin atrophy and pigment rebound. Oral vitamin C and E are commonly used, but the curative effect is not satisfactory. Traditional Chinese medicine has a long history of treatment of chloasma, and the treatment of traditional Chinese medicine focuses on regulating endocrine, curing the disease and curing the root cause. At present, there are more and more traditional Chinese medicine anti-freckle products based on the theory of traditional Chinese medicine, but their preparation process is complicated, and the pertinence of the users is not clear, which leads consumers to choose blindly and regard the facial skin as an "experimental field". Allergies, the effect of freckle removal is not ideal, and the spots may even aggravate. Therefore, developing an effective Chinese medicine freckle-removing product has become the common focus of today's medical circles and cosmetology circles.

Contents of the invention

The object of the present invention is to provide a traditional Chinese medicine composition for removing freckles and its preparation method and application.

The invention provides a traditional Chinese medicine composition for removing freckles, which is a preparation prepared from raw materials containing the following weight ratios:

18-20 parts of angelica, 18-20 parts of peach kernel, 18-20 parts of Chuanxiong, 25-30 parts of salvia miltiorrhiza, 25-30 parts of Chinese yam, 12-15 parts of talc, 18-20 parts of duckweed, 18-20 parts of white poria cocos , 18-20 parts of Atractylodes macrocephala, 18-20 parts of white clove, 18-20 parts of white aconite, 18-20 parts of white silkworm, 18-20 parts of bletilla striata, 18-20 parts of white pomegranate, 18-20 parts of angelica, pearl powder 12-15 parts, mung beans 25-30 parts.

Further preferably, it is a preparation prepared from raw materials in the following weight ratio:

18-20 parts of angelica, 18-20 parts of peach kernel, 18-20 parts of Chuanxiong, 25-30 parts of salvia miltiorrhiza, 25-30 parts of Chinese yam, 12-15 parts of talc, 18-20 parts of duckweed, 18-20 parts of white poria cocos , 18-20 parts of Atractylodes macrocephala, 18-20 parts of white clove, 18-20 parts of white aconite, 18-20 parts of white silkworm, 18-20 parts of bletilla striata, 18-20 parts of white pomegranate, 18-20 parts of angelica, pearl powder 12-15 parts, mung beans 25-30 parts.

More preferably, it is a preparation prepared from raw materials in the following weight ratio:

20 parts of angelica, 20 parts of peach kernel, 20 parts of Chuanxiong, 30 parts of Danshen, 30 parts of Chinese yam, 15 parts of talc, 20 parts of duckweed, 20 parts of white poria, 20 parts of Atractylodes macrocephala, 20 parts of white clove, 20 parts of white aconite, 20 parts of silkworm, 20 parts of Bletilla striata, 20 parts of Baiji, 20 parts of Angelica dahurica, 15 parts of pearl powder, and 30 parts of mung beans.

The composition of the present invention is composed of angelica, peach kernel, chuanxiong, salvia, yam, talc, duckweed, white poria cocos, Atractylodes macrocephala, white clove, aconite, white silkworm, bletilla striata, bletilla, angelica, pearl powder, mung bean An external preparation prepared by adding pharmaceutically acceptable adjuvants or auxiliary ingredients to pharmaceutical powder, or water or organic solvent extract as the active ingredient.

Wherein, the dosage form of the external preparation is tincture, ointment, gel, lotion, liniment, emulsion, film.

Wherein, the auxiliary ingredients include kojic acid, ursolic acid, vitamin E, vitamin E and its derivatives or vitamin C.

The present invention also provides a kind of preparation method of described freckle-removing traditional Chinese medicine composition, and it comprises the steps:

a, take the raw material medicine of each weight ratio;

b. External preparation prepared by powdering, or decocting and extracting with water or organic solvent, and adding pharmaceutically acceptable excipients or auxiliary ingredients.

Described organic solvent is ethanol.

The invention also provides the use of the composition in the preparation of medicaments or cosmetics with anti-freckle effect.

Wherein, the medicine or cosmetic is a medicine or cosmetic for treating chloasma.

The present invention also provides the use of the composition in the preparation of medicines or cosmetics for treating or alleviating insomnia, irritability, constipation, and improving menstrual conditions.

The invention also provides the use of the composition in preparing medicines or cosmetics with the functions of whitening skin, increasing skin lubrication and elasticity, tightening skin, delaying skin aging, lightening brown spots and removing skin blackheads.

Chloasma is mostly caused by liver failure, poor circulation of qi and blood, and failure to grow on the skin; or due to improper diet, overwork, spleen failure, and phlegm stains on the face; or due to Deficiency of liver and kidney yin, water deficiency cannot control fire, and deficiency of fire will cause brown spots on the face. Angelica sinensis, peach kernel, Chuanxiong, and Danshen in the prescription of the pharmaceutical raw materials of the present invention play the role of promoting blood circulation and removing blood stasis. Among them, angelica and Chuanxiong are the products of Xinwen Xingsan, which can not only dissipate blood stasis and activate blood circulation, but also are compatible with white silkworm, white pomegranate, and white monkshood It can also dissipate phlegm and dampness. Peach kernels and salvia miltiorrhiza are bitter in nature, which not only avoids excessive consumption of yin and blood in the prescription, but also removes blood stasis and promotes regeneration, and speeds up the metabolism of ecchymosis. "Compendium of Materia Medica" evaluation Salvia miltiorrhiza: "can break old blood and replenish new blood". Radix Aconiti, Bombyx mori, Radix Sinensis, and Angelica dahurica can dry dampness, resolve phlegm and dissipate stagnation, and together with the above-mentioned blood-activating drugs, can eliminate the pathogenic factors of chloasma with mixed phlegm and blood stasis. "The spleen is the source of phlegm", yam, Poria cocos, and Atractylodes macrocephala invigorate the spleen, promote dampness and resolve phlegm. Playing the function of warming the kidney and invigorating the spleen can relieve the root cause of the disease from the pathogenesis. The bletilla striata, angelica dahurica, white pomegranate, white silkworm, white aconite, white clove, and white tuckahoe contained in the prescription are the basic medicines of Qibai San, which is good at removing turbid stagnation and treating dark spots on the face. Recipe: Angelica dahurica can grow the skin, moisturize the color, "drive away the wind of wandering skin", white tuckahoe has the effect of removing acne and scars, bletilla striata nourishes the skin, making the skin smooth, and white clove has the effect of eliminating accumulation and cloudiness, which can "remove the skin". freckles on the face", white silkworm and white aconite have the effect of dispelling wind and resolving phlegm, so that stagnation can be circulated and stagnation can be excreted. The duckweed in the prescription belongs to the lung meridian, and it is compatible with talc, mung bean, pearl powder and other heat-clearing and refreshing products, which can eliminate the stagnation of dryness, heat and toxins in the skin. The power of the original formula makes the original formula more whitening on the basis of blemishes.

The traditional Chinese medicine composition for removing freckles provided by the invention has precise compatibility, and the flavors of the medicines complement each other. Moreover, the traditional Chinese medicine composition for removing freckles of the present invention is safe to use, has few side effects, and can also treat or relieve insomnia, irritability, constipation, and improve menstrual conditions; whiten the skin, increase skin lubrication and elasticity, tighten skin, delay skin aging, and fade. Brown spots, clear skin blackhead effect.

Detailed ways

The following examples are used for further description, but the present invention is not limited to these examples.

Embodiment 1 The preparation of the freckle-removing traditional Chinese medicine composition of the present invention

Weigh each weight raw material: Angelica 20g, peach kernel 20g, Chuanxiong 20g, salvia miltiorrhiza 30g, Chinese yam 30g, talc 15g, duckweed 20g, white poria cocos 20g, Atractylodes macrocephala 20g, white clove 20g, white aconite 20g, white silkworm 20g, 20g of bletilla striata, 20g of bletilla striata, 20g of angelica dahurica, 15g of pearl powder, and 30g of mung beans.

Preparation:

Each traditional Chinese medicine component is weighed according to the above-mentioned weight ratio, pulverized, and the particle size after pulverization is controlled at 50-90um, and water, or milk, or egg white is added, stirred evenly, and honey is added to mix thoroughly.

Instructions:

Apply the above-mentioned prepared medicine evenly on the face. After about 20 minutes, rinse it with clean water. After washing the face, dip a cotton pad with olive oil and apply it on the face for about 5 minutes. Cover the face with a towel, and you don’t need to remove the cotton pad at this time. After the towel cools down, take off the towel and cotton pad and wash your face.

Embodiment 2 Preparation of dosage forms of the freckle-removing Chinese medicine composition of the present invention

A. Extract simple dosage form preparation

Weigh the raw materials of each weight ratio: Angelica 18g, peach kernel 18g, Chuanxiong 18g, salvia miltiorrhiza 25g, yam 25g, talc 12g, duckweed 18g, white poria cocos 18g, Atractylodes macrocephala 18g, white clove 18g, aconite 18g, white jelly Silkworm 18g, Bletilla striata 18g, Baiji 18g, Angelica dahurica 18g, pearl powder 12g, mung bean 25g.

Preparation:

Each traditional Chinese medicine component is weighed according to the above weight ratio, crushed, extracted with water or ethanol to obtain an extract, dried, and crushed again, and the crushed particle size is controlled at 50-90um to obtain the active ingredient raw drug. After the active ingredient is powdered, add 500ml of pure water, or 500ml of milk, or 500ml of egg white, stir well, then add honey and mix thoroughly.

Instructions:

Apply the above-mentioned prepared medicine evenly on the face. After about 20 minutes, rinse it with clean water. After washing the face, dip a cotton pad with olive oil and apply it on the face for about 5 minutes. Cover the face with a towel, and you don’t need to remove the cotton pad at this time. After the towel cools down, take off the towel and cotton pad and wash your face.

B, preparation of extract ointment dosage form

Weigh the raw materials of each weight ratio:

Angelica 20g, peach kernel 20g, chuanxiong 20g, salvia miltiorrhiza 30g, yam 30g, talc 15g, duckweed 20g, white tuckahoe 20g, atractylodes rhizome 20g, white clove 20g, aconite 20g, silkworm 20g, bletilla striata 20g, bletilla 20g, Angelica dahurica 20g, pearl powder 15g, mung bean 30g.

Preparation:

(1) 60g of glycerin, 90g of stearic acid, 30g of triethanolamine, 100g of liquid paraffin, 70g of paraffin, 10g of ethylparaben, and 400ml of pure water are used as auxiliary materials, which are acceptable to the human body. After heating and melting, stir evenly and condense, An ointment-type base can be obtained.

(2) Weigh each Chinese medicine component according to the above weight ratio, pulverize, extract with water or ethanol to obtain the extract, dry, pulverize again, and control the pulverized particle size to 50-90um to obtain the active ingredient raw drug.

(3) Add the crude drug obtained in (2) into the matrix obtained in (1) and stir well to make an ointment preparation.

C, preparation of extract cream dosage form

Weigh the raw materials of each weight ratio: Angelica 20g, peach kernel 20g, Chuanxiong 20g, salvia miltiorrhiza 30g, Chinese yam 30g, talc 15g, duckweed 20g, white poria cocos 20g, atractylodes macrocephala 20g, white clove 20g, aconite 20g, Silkworm 20g, Bletilla striata 20g, Baiji 20g, Angelica dahurica 20g, pearl powder 15g, mung bean 30g.

Preparation:

(1) 50 g of polyacrylic acid, 5 g of triethanolamine, 2 g of disodium edetate, 200 g of propylene glycol, 2 g of benzoic acid, and 500 ml of pure water are placed in a container, heated and melted, stirred evenly and condensed to obtain a cream base;

(2) Each traditional Chinese medicine component used as an auxiliary material is weighed according to the above-mentioned weight ratio, crushed, extracted with water or ethanol to obtain an extract, dried, and crushed again, and the crushed particle size is controlled at 50-90um to obtain the active ingredient drug substance.

(3) Add (2) into (1) and stir thoroughly to prepare a cream preparation.

D. Preparation of extract liniment

Weigh the raw materials of each weight ratio: 20g of angelica, 20g of peach kernel, 20g of Chuanxiong, 30g of salvia miltiorrhiza, 30g of Chinese yam, 15g of talc, 20g of duckweed, 20g of white poria cocos, 20g of Atractylodes macrocephala, 20g of white clove, 20g of white aconite, and white silkworm 20g, 20g of bletilla striata, 20g of bletilla striata, 20g of angelica dahurica, 15g of pearl powder, 30g of mung bean.

Preparation:

(1) Put 200ml of ethanol (95%), 20g of phenol, 50g of boric acid, and 500ml of pure water in a container, heat to dissolve, stir evenly and then cool, then it can be used as a disinfectant auxiliary material;

(2) Each traditional Chinese medicine component is weighed according to the above weight ratio, crushed, extracted with water or ethanol to obtain an extract, dried, and crushed again, and the crushed particle size is controlled at 50-90um to obtain the active ingredient drug substance.

(3) Add (2) into (1) and stir evenly to obtain the whitening and freckle-removing liniment with disinfection function.

E. Preparation of extract tincture

Weigh the raw materials of each weight ratio:

Angelica 20g, peach kernel 20g, chuanxiong 20g, salvia miltiorrhiza 30g, yam 30g, talc 15g, duckweed 20g, white tuckahoe 20g, atractylodes rhizome 20g, white clove 20g, aconite 20g, silkworm 20g, bletilla striata 20g, bletilla 20g, Angelica dahurica 20g, pearl powder 15g, mung bean 30g.

(1) Each traditional Chinese medicine component is weighed according to the above weight ratio, crushed, extracted with water or ethanol to obtain an extract, dried, and crushed again, and the crushed particle size is controlled at 50-90um to obtain the active ingredient drug substance.

(2) slowly add (1) into 300ml of ethanol (95%), stir evenly, and then the tincture dosage form can be prepared.

Example 3 Preparation of a combined dosage form of the freckle-removing traditional Chinese medicine composition of the present invention and other whitening monomer compounds

Weigh the raw materials of each weight ratio:

Angelica 20g, peach kernel 20g, chuanxiong 20g, salvia miltiorrhiza 30g, yam 30g, talc 15g, duckweed 20g, white tuckahoe 20g, atractylodes rhizome 20g, white clove 20g, aconite 20g, silkworm 20g, bletilla striata 20g, bletilla 20g, Angelica dahurica 20g, pearl powder 15g, mung bean 30g.

Preparation:

Each traditional Chinese medicine component is weighed according to the above weight ratio, crushed, extracted with water or ethanol to obtain an extract, dried, and crushed again, and the crushed particle size is controlled at 50-90um to obtain the active ingredient raw drug.

After the active ingredient is powdered, add 500ml of pure water and heat to dissolve evenly, then add arbutin (the total amount does not exceed 7% of the total amount of the extract), or add kojic acid (the total amount accounts for 0.5% of the total amount of the extract— 2%), and stir evenly to obtain the whitening combination preparation.

Example 4 Various dosage forms can be prepared by combining the freckle removing traditional Chinese medicine composition of the present invention with other whitening monomer compounds

Each Chinese medicine ingredient was weighed according to the following weight ratio: Angelica 20g, peach kernel 20g, Chuanxiong 20g, salvia miltiorrhiza 30g, Chinese yam 30g, talc 15g, duckweed 20g, white poria cocos 20g, Atractylodes macrocephala 20g, white clove 20g, white aconite 20g, 20g white silkworm, 20g bletilla striata, 20g bletilla, 20g angelica, 15g pearl powder, 30g mung bean. After pulverization, the extract is extracted with water or ethanol, dried, and pulverized again, and the pulverized particle size is controlled at 50-90um, so that the active ingredient raw material drug can be obtained.

The above-mentioned raw material powder adopts the preparation method of multiple dosage forms in Example 2, and adds arbutin (the total amount is no more than 7% of the total amount of the extract) during the mixing process, or adds kojic acid (the total amount accounts for 7% of the total amount of the extract). 05%-2%), and stir evenly to obtain combined ointment, cream, liniment and tincture with whitening and freckle-removing properties.

Instructions:

Apply the above-mentioned prepared medicine evenly on the face. After about 20 minutes, rinse it with clean water. After washing the face, dip a cotton pad with olive oil and apply it on the face for about 5 minutes. Cover the face with a towel, and you don’t need to remove the cotton pad at this time. After the towel cools down, take off the towel and cotton pad and wash your face.

Embodiment 5 Preparation of freckle-removing facial mask of the present invention

Preparation method 1:

Each Chinese medicine ingredient was weighed according to the following weight ratio: Angelica 20g, peach kernel 20g, Chuanxiong 20g, salvia miltiorrhiza 30g, Chinese yam 30g, talc 15g, duckweed 20g, white poria cocos 20g, Atractylodes macrocephala 20g, white clove 20g, white aconite 20g, 20g of white silkworm, 20g of bletilla striata, 20g of bletilla striata, 20g of angelica dahurica, 15g of pearl powder, and 30g of mung bean, after pulverized, extract with water or ethanol to obtain the extract, dry, and pulverize again, and the pulverized particle size is controlled at 50-90um to obtain Active ingredient API.

Add 400ml of pure water, or milk (400ml), or 400ml of yoghurt, or 400ml of egg white to the above raw material powder, stir well, add honey and mix thoroughly, and prepare a whitening and freckle-removing raw material liquid medicine. Take out the purchased facial mask paper, put it in the raw material liquid medicine and soak it completely (20min), and take it out to get the freckle removing mask.

Preparation method 2:

Each Chinese medicine ingredient was weighed according to the following weight ratio: Angelica 20g, peach kernel 20g, Chuanxiong 20g, salvia miltiorrhiza 30g, Chinese yam 30g, talc 15g, duckweed 20g, white poria cocos 20g, Atractylodes macrocephala 20g, white clove 20g, white aconite 20g, 20g white silkworm, 20g bletilla striata, 20g bletilla, 20g angelica, 15g pearl powder, 30g mung bean. After pulverization, the extract is extracted with water or ethanol, dried, and pulverized again, and the pulverized particle size is controlled at 50-90um, so that the active ingredient raw material drug can be obtained.

Add 400ml of pure water, or milk (400ml), or 400ml of yogurt, or 400ml of egg white to the above-mentioned raw material powder, stir well, then add honey or a small amount of flour, mix thoroughly until it becomes a paste, and the whitening and freckle-removing raw material medicinal liquid can be prepared. Can be applied directly to the face.

Preparation method 3:

Each traditional Chinese medicine ingredient is weighed according to the following weight ratio: Angelica 20g, peach kernel 20g, Chuanxiong 20g, salvia miltiorrhiza 30g, yam 30g, talc 15g, duckweed 20g, white poria cocos 20g, Atractylodes macrocephala 20g, white clove 20g, white aconite 20g , Baizhu silkworm 20g, bletilla striata 20g, bletilla 20g, angelica dahurica 20g, pearl powder 15g, mung bean 30g. After pulverization, the extract is extracted with water or ethanol, dried, and pulverized again, and the pulverized particle size is controlled at 50-90um, so that the active ingredient raw material drug can be obtained.

Add 400ml of pure water, or milk (400ml), or 400ml of yogurt, or 400ml of egg white to the above raw material powder, stir well, add 2-3 drops of natural vitamin E, or add an appropriate amount of lemon juice, and the whitening and freckle-removing raw material can be prepared. Take out the purchased facial mask paper, put it in the raw medicine solution and soak it completely (20min), and take it out to get the enhanced whitening and freckle removing mask.

Instructions:

Spread the above mask evenly, or apply it on the face. After about 20 minutes, rinse it with clean water. After washing the face, dip a cotton pad with olive oil and apply it on the face for about 5 minutes. Cover the face with a towel, and you don’t need to remove the cotton pad at this time. After the towel cools down, take off the towel and cotton pad and wash your face.

The beneficial effects of the present invention will be specifically described below through test examples.

Test example 1 Clinical observation of freckle-removing mask of the present invention in treating chloasma

(1) Criteria for admitted patients (or diagnostic criteria)

Gender and age range of patients: 120 patients, aged 20 to 50 years old, 110 females, 10 males, the shortest duration of the disease is 6 months, the longest is 25 years, the shortest treatment time is 1 month, and the longest is 6 months.

Diagnostic criteria: The diagnosis of chloasma refers to the relevant standards in the formulation of the "Clinical Diagnosis and Curative Effect Judgment Standards for Chloasma 2003 Revised Draft" formulated by the Pigment Disease Group of the Professional Committee of Skin and Venereology of the Chinese Association of Integrative Traditional Chinese and Western Medicine in December 2003: ① Facial light brown to dark brown, well-defined patches, usually symmetrically distributed, without inflammation and fish scales ②No obvious subjective symptoms ③Mainly occurs after puberty, mostly in women ④The disease has a certain seasonality, summer is milder in winter ⑤ Pigmentation caused by other diseases (such as zygomatic nevus, melanosis, pigmented actinic lichen planus) was excluded.

Symptom characteristics of traditional Chinese medicine (or Western medicine): symmetrically occur on the face, especially on the cheeks, forehead, and nose, and the skin lesions are light brown, dark brown, and light black patches, with different sizes and shapes. Clear, no symptoms, aggravated after sun exposure.

Diagnosis: Melasma

(2) Standard of treatment

It was formulated with reference to the relevant standards in the "2003 Revised Draft of Clinical Diagnosis and Curative Effect Judgment Standards for Melasma" formulated by the Pigment Disease Group of the Skin and Venereal Disease Professional Committee of the Chinese Society of Integrative Medicine in December 2003.

Basic cure: >90% of the pigmentation area disappears with the naked eye, the color of the skin lesions basically disappears to a normal skin color, and the patient's insomnia, irritability, constipation, and menstrual conditions have improved significantly;

Significantly effective: the area of pigmentation subsides >60% with the naked eye, the color of the skin lesions is obviously lightened to light brown, and the patient's insomnia, irritability, constipation, and menstrual conditions are improved;

Effective: The area of pigmentation faded by more than 30% with the naked eye, the color of skin lesions became light brown, and the patient's insomnia, irritability, constipation, and menstrual conditions improved;

Ineffective: The area of pigmentation faded by more than 30% with the naked eye, and the color of the skin lesions did not change significantly to dark brown. The patient's insomnia, irritability, constipation, and menstrual conditions did not improve.

(3) Treatment methods

1. Administration method:

After a definite diagnosis, 120 patients were treated with the following drugs: Angelica 20g, peach kernel 20g, Chuanxiong 20g, salvia miltiorrhiza 30g, yam 30g, talc 15g, duckweed 20g, white poria cocos 20g, atractylodes macrocephala 20g, white clove 20g, aconite 20g, 20g white silkworm, 20g bletilla striata, 20g bletilla, 20g angelica, 15g pearl powder, 30g mung bean.

Twice a week, each time the total weight of the Chinese medicine composition is 360g, take the Chinese medicine composition (360g) and grind it into powder, add water, or milk, or egg white, mix well, add honey, mix thoroughly and apply on the face evenly, 12 times is a course of treatment , for 2 consecutive courses of treatment. During the treatment period, no other western medicine and other treatments are provided.

During the treatment period, the diet should be light, avoid fat, sweet and thick food, avoid sweets, seafood and hot fruits, avoid smoking and alcohol, and ask to eat more vegetables.

2. Those with no obvious drug contraindications and sensitive skin.

(4) Treatment results

Duration of treatment: 12 weeks

Judgment of curative effect: the results are as follows

Table 1 The curative effect of 120 patients after 12 weeks of treatment

treatment result Number of cases (cases) Efficient(%) get well 20 16.66 markedly effective 18 15.00 efficient 62 51.66 invalid 20 16.66 total 120 83.40

After 12 weeks of treatment, among 120 patients, 20 were cured, 18 were markedly effective, 62 were effective, and 20 were ineffective. The total effective rate reached 83.4%.

Adverse reactions: No adverse reactions were seen during the medication period. Occasionally, some patients had slight skin itching at the beginning of treatment, which was relieved and controlled after adjusting the dosage. Some patients had no abnormality in blood examination, liver and kidney function.

It can be seen from the test results that all patients with chloasma had no adverse reactions and no recurrence. The freckle-removing facial mask of the invention has remarkable curative effect on alleviating the condition of patients with chloasma.

Clinical observation shows that the freckle removing mask of the present invention can improve local skin capillary microcirculation, increase capillary permeability, promote metabolism, activate skin cells, open pores, and quickly allow nutrients required by the skin and active anti-oxidant ingredients of traditional Chinese medicine to penetrate deep into the skin. Combined with the reticular connective tissue of skin cells, it can effectively promote blood circulation and remove blood stasis, repair and stimulate cell activity, lock in moisture, increase skin elasticity, remove harmful substances from the skin, remove aging skin cells, detoxify, and replenish skin The required nutrients, minerals, etc., so as to achieve whitening skin, increase skin lubrication and elasticity, firm skin, delay skin aging, lighten brown spots, and remove skin blackheads.

(5) Typical cases

Patient Zhang, female, 28 years old. The patient had dark brown patches on the cheeks, dull complexion, and irregular menstruation after long-term oral contraceptive pills. Oral vitamin C and external application of Qianbai hydroquinone cream (specific usage is unknown) were ineffective. Recently, the patient felt that the spots on the face deepened and the spots increased, and the diagnosis was made immediately: the spots on the cheeks were dark brown, the complexion was dull, irritability, irregular menstruation, breast tenderness before menstruation, poor sleep, poor appetite, dry mouth and difficulty drinking Solution, two will be enough, the tongue is red, the fur is thin, and the pulse is stringy. Diagnosed as liver depression and qi stagnation type chloasma. It is suitable for soothing the liver and regulating qi, promoting blood circulation and eliminating stasis. Use the specific implementation method of the present invention, twice a week; and advise the patient to maintain a comfortable mood, avoid sun exposure, stop using contraceptives, live a regular life, use irritating cosmetics with caution, and eat a light diet. According to the above treatment for 1 course of treatment, the color of skin lesions became lighter and the skin lesions decreased; after another 1 course of treatment, the color of skin lesions became normal skin color.

Claims (10)

1. a freckle removal traditional Chinese medicinal composition, is characterized in that: it is the preparation be prepared from by the crude drug containing following weight proportioning:

Radix Angelicae Sinensis 18-20 part, Semen Persicae 18-20 part, Rhizoma Chuanxiong 18-20 part, Radix Salviae Miltiorrhizae 25-30 part, Rhizoma dioscoreae 25-30 part, Talcum 12-15 part, Herba Spirodelae 18-20 part, Poria 18-20 part, Rhizoma Atractylodis Macrocephalae 18-20 part, Faeces Passeris 18-20 part, Rhizoma Typhonii 18-20 part, Bombyx Batryticatus 18-20 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 18-20 part, Radix Ampelopsis 18-20 part, Radix Angelicae Dahuricae 18-20 part, Margarita powder 12-15 part, Semen phaseoli radiati 25-30 part.

2. freckle removal traditional Chinese medicinal composition according to claim 1, is characterized in that: it is the preparation be prepared from by the crude drug of following weight proportioning:

Radix Angelicae Sinensis 18-20 part, Semen Persicae 18-20 part, Rhizoma Chuanxiong 18-20 part, Radix Salviae Miltiorrhizae 25-30 part, Rhizoma dioscoreae 25-30 part, Talcum 12-15 part, Herba Spirodelae 18-20 part, Poria 18-20 part, Rhizoma Atractylodis Macrocephalae 18-20 part, Faeces Passeris 18-20 part, Rhizoma Typhonii 18-20 part, Bombyx Batryticatus 18-20 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 18-20 part, Radix Ampelopsis 18-20 part, Radix Angelicae Dahuricae 18-20 part, Margarita powder 12-15 part, Semen phaseoli radiati 25-30 part.

3. freckle removal traditional Chinese medicinal composition according to claim 2, is characterized in that: it is the preparation be prepared from by the crude drug of following weight proportioning:

Radix Angelicae Sinensis 20 parts, 20 parts, Semen Persicae, Rhizoma Chuanxiong 20 parts, Radix Salviae Miltiorrhizae 30 parts, Rhizoma dioscoreae 30 parts, 15 parts, Talcum, 20 parts, Herba Spirodelae, Poria 20 parts, the Rhizoma Atractylodis Macrocephalae 20 parts, Faeces Passeris 20 parts, Rhizoma Typhonii 20 parts, Bombyx Batryticatus 20 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 20 parts, Radix Ampelopsis 20 parts, the Radix Angelicae Dahuricae 20 parts, Margarita powder 15 parts, 30 parts, Semen phaseoli radiati.

4. the freckle removal traditional Chinese medicinal composition according to claim 1-3 any one, it is characterized in that: it is active component by the protogenic medicinal powder of Radix Angelicae Sinensis, Semen Persicae, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Rhizoma dioscoreae, Talcum, Herba Spirodelae, Poria, the Rhizoma Atractylodis Macrocephalae, Faeces Passeris, Rhizoma Typhonii, Bombyx Batryticatus, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Ampelopsis, the Radix Angelicae Dahuricae, Margarita powder, Semen phaseoli radiati or water or extractive with organic solvent, add the external preparation that pharmaceutically acceptable adjuvant or complementary composition are prepared from.

5. freckle removal traditional Chinese medicinal composition according to claim 4, is characterized in that: the dosage form of described external preparation is tincture, unguentum, gel, lotion, liniment, emulsion, membrane.

6. freckle removal traditional Chinese medicinal composition according to claim 4, is characterized in that: described complementary composition comprises kojic acid, ursolic acid, vitamin E, vitamin E and derivant thereof or vitamin C.

7. the preparation method of the freckle removal traditional Chinese medicinal composition described in claim 1 ~ 6 any one, it comprises the steps:

A, take the crude drug of each weight proportion;

B, beat powder, or to add water or organic solvent decocts and extracts, add the external preparation that pharmaceutically acceptable adjuvant or complementary composition are prepared from.

8. compositions described in claim 1 ~ 6 any one is preparing the purposes in the medicine or cosmetics with spot-removal function.

9. purposes according to claim 8, is characterized in that: described medicine or cosmetics are medicine or the cosmetics for the treatment of chloasma.

10. compositions described in claim 1 ~ 6 any one is being prepared treatment or relieving insomnia, irritable, constipation symptom, is being improved menstruation; Tender pale skin, increases skin lubrication and elasticity, the skin that compacts, delay skin aging, lightly move back brown patch, purposes in the medicine of removing skin blackhead effect or cosmetics.