CN107714798B - A kind of traditional Chinese medicine composition for treating chloasma and preparation method thereof - Google Patents

Abstract

The invention provides a traditional Chinese medicine composition for treating chloasma and a preparation method thereof, and relates to the technical field of traditional Chinese medicines. A traditional Chinese medicine composition for treating chloasma is mainly prepared from the following raw materials in parts by weight: cassia twig, poria cocos, peach kernel, red paeony root, white paeony root, cortex moutan, Chinese angelica, radix bupleuri, bighead atractylodes rhizome, liquorice, mint, rose, safflower and flos mume. Is safe to use, and can fade or fade facial color spots, improve skin appearance and improve life quality. A preparation method of a traditional Chinese medicine composition for treating chloasma comprises the following steps: drying the raw materials, pulverizing, and mixing with adjuvants. The preparation method is simple and easy to implement, has strong operability, maintains the drug effect, is easy for industrial production, and is convenient for patients to carry and take on time by changing the dosage form.

Description

A kind of traditional Chinese medicine composition for treating chloasma and preparation method thereof

technical field

The invention relates to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating chloasma and a preparation method thereof.

Background technique

Chloasma, also known as liver spot, is a kind of facial pigmentation disease that occurs mainly in women. It has a high clinical incidence and is characterized by yellow or dark brown patches. , forehead, upper lip and nose, the edges are generally more pronounced. The depth of pigmentation is related to seasons, sun exposure, and endocrine factors. Mental stress, staying up late, and fatigue can aggravate skin lesions. The clinical incidence of chloasma is relatively high, and the etiology is still unclear. Western medicine believes that its incidence is related to pregnancy, long-term oral contraceptives, menstrual disorders, and gynecological diseases. Although this disease generally does not affect health, persistent or increased or deepened facial pigmentation will affect people's appearance and thus reduce people's quality of life.

At present, western medicine treatment methods for chloasma mostly use sunscreen, topical depigmentation agent, facial mask, laser, or oral vitamin C and E, but they can only improve the melasma in the short term, are prone to recurrence and aggravation, and cannot solve other accompanying symptoms.

SUMMARY OF THE INVENTION

The purpose of the present invention is to provide a traditional Chinese medicine composition for treating chloasma, which is safe to use, can lighten or subside facial pigmentation, improve skin appearance, and improve quality of life.

Another object of the present invention is to provide a preparation method of a traditional Chinese medicine composition for treating chloasma. The preparation method is simple and easy to operate, has strong operability, and is easy to industrialize production while maintaining the efficacy. Change, easy for patients to take with them.

The present invention solves its technical problems by adopting the following technical solutions.

The invention provides a traditional Chinese medicine composition for treating chloasma, which is mainly prepared from the following raw materials in parts by weight: 5-15 parts of cinnamon sticks, 10-20 parts of Poria cocos, 5-15 parts of peach kernels, Radix Paeoniae Alba 10-20 servings, 10-20 servings of white peony root, 10-20 servings of paeonol, 15-25 servings of angelica, 5-15 servings of Bupleurum, 10-20 servings of Atractylodes, 2-8 servings of licorice, 5-15 servings of mint, 15 to 25 roses, 10 to 20 safflowers, and 10 to 20 green calyx plums.

The present invention provides a preparation method of a traditional Chinese medicine composition for treating chloasma, which comprises: drying and pulverizing raw materials, and mixing with auxiliary materials.

The beneficial effects of a traditional Chinese medicine composition for treating chloasma and a preparation method thereof according to the embodiment of the present invention are:

The invention refers to modern drug research and combines clinical experience to form a scientific formula. Guizhi warms the meridians, helps yang to transform qi; Poria invigorates the spleen and calms the heart; Peach kernel promotes blood circulation and removes blood stasis; Skin activating blood and removing blood stasis; Angelica tonifying blood and promoting blood circulation; Chaihu soothing liver and relieving stagnation; Bai Zhu invigorating spleen and nourishing qi; Licorice tonifying spleen and nourishing qi; Peppermint soothing liver and promoting qi; Rose flower clearing heat and detoxifying; Stomach, adjust Qi machine.

The formula has the functions of "soothing the liver and spleen, relieving depression and light spots, promoting blood circulation and removing blood stasis", which can regulate the body's immunity, improve blood circulation, scavenge free radicals, improve antioxidant properties, thereby inhibiting the activity of tyrosinase , reduces the formation of melanin, lightens or fades melasma, improves skin appearance and improves quality of life. At the same time, the prescription has a certain therapeutic effect on irritability and depression, dizziness and tinnitus, breast tenderness before menstruation, abdominal distention pain, light menstrual flow and other symptoms, as well as gynecological tumors or cysts. The prescription adopts natural Chinese herbal medicine as raw material, and has high safety performance and no toxic and side effects.

Detailed ways

In order to make the objectives, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be described clearly and completely below. If the specific conditions are not indicated in the examples, it is carried out according to the conventional conditions or the conditions suggested by the manufacturer. The reagents or instruments used without the manufacturer's indication are conventional products that can be purchased from the market.

A traditional Chinese medicine composition for treating chloasma and a preparation method thereof according to an embodiment of the present invention will be specifically described below.

A kind of traditional Chinese medicine composition for the treatment of chloasma provided by the embodiment of the present invention, by weight, is mainly made from the following raw materials:

5-15 parts of cinnamon sticks, 10-20 parts of Poria, 5-15 parts of peach kernel, 10-20 parts of red peony root, 10-20 parts of white peony root, 10-20 parts of paeonol, 15-25 parts of angelica root, 5-20 parts of bupleurum 15 parts, Atractylodes 10-20 parts, Licorice 2-8 parts, Mint 5-15 parts, Rose 15-25 parts, Safflower 10-20 parts, Green calyx plum 10-20 parts. Preferably, cassia twig can be 6 parts, 7 parts, Poria can be 11 parts, peach kernel can be 6 parts, 7 parts, red peony can be 11 parts, white peony can be 11 parts, paeony can be 11 parts, Angelica can be 16, 17, Bupleurum can be 6, 7, Atractylodes can be 11, Danpi can be 11, Angelica can be 16, 17, Bupleurum can be 6, 7 , Atractylodes can be 11 parts, licorice can be 3 parts, 4 parts, 6 parts, 7 parts, mint can be 6 parts, 7 parts, rose can be 16 parts, 17 parts, safflower can be 11 parts, green calyx can be 11 parts Plum can be 11 servings.

Further, in a preferred embodiment of the present invention, in parts by weight, the raw materials include: 8-12 parts of cassia twig, 12-18 parts of Poria, 8-12 parts of peach kernel, 12-18 parts of red peony root, white peony root 12-18 parts, 12-18 parts of Danpi, 18-22 parts of Angelica, 8-12 parts of Bupleurum, 12-18 parts of Atractylodes, 2-8 parts of Licorice, 8-12 parts of Peppermint, 18-22 parts of Rose, 12 to 18 copies of safflower, 12 to 18 copies of green calyx plum. Preferably, cassia twig can be 9 parts, 11 parts, Poria can be 13 parts, 14 parts, 16 parts, 17 parts, peach kernel can be 9 parts, 11 parts, red peony can be 13 parts, 14 parts, 16 parts , Bai Shao can be 14, 16, 17, Danpi can be 13, 17, Angelica can be 19, 21, Bupleurum can be 9, 11, Atractylodes can be 13, 17 9 and 11 parts of mint, 14 and 16 parts of safflower, and 13 and 17 parts of green calyx plum.

Guizhi, pungent, sweet, warm. Return to the heart, lung and bladder meridians. It has the effect of warming the meridians, helping the yang to transform the qi, and calming the qi and lowering the qi. Guizhi can warm the middle and dispel cold, promote blood-activating drugs, and enhance the effect of removing blood stasis.

Poria, sweet, light, flat. Return to the heart, lung, spleen and kidney meridians. It has the effect of invigorating the spleen and calming the heart. Poria cocos has a mild medicinal property, benefits water without harming righteousness, and is compatible with Guizhi and Atractylodes for better medicinal effect.

Peach kernel, bitter, sweet, flat. Return to the heart, liver and large intestine meridians. It has the effect of promoting blood circulation and removing blood stasis, moistening intestines and laxative. Peach kernels can dilate blood vessels, promote blood circulation, and promote detoxification of the body.

Red peony, bitter, slightly cold. Return to the liver meridian. It has the effect of clearing heat and cooling blood, dissipating blood stasis and relieving pain. Danpi, also known as Cortex Moutan, is bitter, acrid, slightly cold, and returns to the heart, liver and kidney meridians. It has the effect of clearing heat and cooling blood, promoting blood circulation and removing blood stasis. Red peony and Danpi work together to clear blood and dissipate blood stasis.

Paeonia lactiflora, bitter, sour, slightly cold. Return to the liver and spleen meridians. It has the functions of nourishing blood and regulating menstruation, astringing yin and stopping sweating, and calming down liver yang. Paeonia lactiflora has obvious liver-protecting effects and better enhancement of hypoxia tolerance, anti-oxidation, and anti-fatigue effects, which can improve human immunity.

Angelica, sweet, pungent, warm. Returns liver, heart and spleen meridians. It has the functions of nourishing blood and promoting blood circulation, regulating menstruation and relieving pain, and moistening the bowels. It can be used for deficiency of heart, liver and blood, and irregular menstruation. Atractylodes, bitter, sweet, warm. Return to the spleen and stomach meridians. It has the effect of invigorating the spleen and nourishing qi, drying dampness and diuretic water. Protect liver and enhance immunity.

Bupleurum, acrid, bitter, slightly cold. Returns liver, gallbladder, lung meridian. It has the effect of dispersing fever, soothing the liver and relieving depression. "Southern Yunnan Materia Medica" records that Bupleurum "introduces the qi of the liver meridian against the knot, stops the spasm of liver qi in the left flank, treats women's blood heat and burns the meridian, and can regulate menstruation." "Drug Huayi" said: "The taste is slightly bitter, Mainly soothes the liver." Bupleurum can regulate liver qi and relieve stagnation, which can be used to treat stagnation, irregular menstrual water, and heat entering the blood chamber.

Licorice, sweet, flat. Return to the heart, lung, spleen and stomach meridians. It has the functions of invigorating the spleen and replenishing qi, clearing away heat and detoxifying, helping the body to metabolize and expel toxins. Licorice also has the effect of reconciling various medicines.

Mint, spicy, cool. Returns the lung and liver meridians. It has the effect of dispersing wind-heat, clearing the head, and soothe liver and qi. Rose, bitter, cold. Returns the lung and large intestine meridians. It has the functions of clearing away heat and detoxifying, regulating qi and blood, detoxifying and nourishing the face, soothing the liver and relieving depression.

Safflower, pungent, warm. Heart, liver meridian. It has the effect of promoting blood circulation for dysmenorrhea, dispersing blood stasis and relieving pain. It has good curative effect on dysmenorrhea, amenorrhea, postpartum haemorrhage, abdominal pain due to stasis, chest pain, and blood accumulation.

Green calyx plum, sour, astringent, flat. Returns liver, stomach, lung meridian. It has the effect of calming the liver and stomach and regulating Qi. Green calyx plum transports qi into the liver and stomach, soothes the liver and relieves depression, refreshes the spleen, regulates qi and neutralizes the middle.

Cinnamon twig, Poria, peach kernel, white peony root, red peony root, angelica, Atractylodes, Bupleurum, mint, safflower and green calyx plum are compatible, with synergistic effect, soothing liver and spleen, relieving depression and reducing spots, promoting blood circulation Blood stasis, licorice reconciles various medicines, assists in clearing away heat and detoxifying. The formula promotes metabolism in the body, improves blood circulation, removes excess free radicals in the body, and improves antioxidant properties, thereby inhibiting the activity of tyrosinase and reducing the formation of melanin, thereby diluting or eliminating chloasma and improving the skin; At the same time, it has a certain therapeutic effect on symptoms such as irritability and depression, dizziness and tinnitus, breast tenderness before menstruation, abdominal distention pain, light menstrual flow, and gynecological tumors or cysts.

Further, in a preferred embodiment of the present invention, in parts by weight, the raw materials are 10 parts of cinnamon sticks, 15 parts of Poria cocos, 10 parts of peach kernels, 15 parts of red peony root, 15 parts of white peony root, 15 parts of paeonol, 15 parts of Chinese angelica 20 parts, Bupleurum 10 parts, Atractylodes 15 parts, Licorice 5 parts, Mint 10 parts, Rose 20 parts, Safflower 12 parts, Green calyx plum 2 parts, the effect is even more. The traditional Chinese medicine provided by the present invention also includes at least one auxiliary material selected from the group consisting of a binder, a disintegrant and a lubricant. By adding excipients, traditional Chinese medicines are made into different dosage forms.

The present invention also provides a preparation method of a traditional Chinese medicine composition for treating chloasma, comprising:

The raw materials are weighed in proportion, washed and dried, pulverized, and mixed to obtain medicinal powder. In order to enhance the absorption of the drug by the human body, preferably, the raw materials are dried under the condition of 40-60°C for 4-6 hours, and the raw materials are pulverized to more than 800 meshes by the ultrafine pulverization technology.

Mix the powder with the excipients and make different dosage forms as needed. In the embodiment of the present invention, in order to be convenient for patients to carry and take, the medicinal powder is mixed with dextrin and compressed to obtain a tablet. And the tablet can improve patient compliance and better ensure clinical efficacy. After drying, inspection and packaging, the finished product is obtained. Preferably, in order to enhance the efficacy of the tablet, the quality of the auxiliary materials is 1-5% of the quality of the raw materials.

The preparation method of the traditional Chinese medicine composition for treating chloasma adopts the method of directly powdering the medicinal materials to prepare the medicine, so that all the components in the medicinal materials can be used as medicine, the utilization rate of the medicinal materials is as high as 99%, and the process of the method is simple. , the prepared medicament has remarkable efficacy.

As another implementation manner, the pulverized medicinal powder can be leached with an alcohol solution to extract the active ingredients in the medicinal powder. Specifically, the ethanol aqueous solution with a volume fraction of 50% to 60% is used for reflux extraction at 60 to 80° C. for 1 to 3 times, and each extraction is performed for 6 to 8 hours. The multiple extracts were mixed and concentrated to dryness. The dried product is mixed with excipients to prepare different dosage forms as required. The preparation method processes the raw materials, extracts the effective components, further enhances the absorption of the medicine by the human body, and has quick effects.

The features and performances of the present invention will be further described in detail below in conjunction with the embodiments.

Example 1

The present embodiment provides a traditional Chinese medicine composition for the treatment of chloasma, obtained by the following preparation method:

In parts by weight, weigh 5 parts of cinnamon stick, 10 parts of Poria, 5 parts of peach kernel, 10 parts of red peony root, 10 parts of white peony root, 10 parts of paeonol, 15 parts of angelica, 5 parts of Bupleurum, 10 parts of Atractylodes, licorice 2 parts, 5 parts mint, 15 parts rose flower, 10 parts safflower, 10 parts green calyx plum.

The raw materials are dried under the condition of 40 ° C for 4 hours, the raw materials are pulverized to 800 meshes by the ultra-fine pulverization technology, and the dextrin with a mass of 1% of the raw materials is mixed with the medicinal powder to make tablets. After drying treatment, inspection and packaging, the obtained finished product.

Example 2

The present embodiment provides a traditional Chinese medicine composition for the treatment of chloasma, obtained by the following preparation method:

In parts by weight, weigh 15 parts of cassia twig, 20 parts of Poria, 15 parts of peach kernel, 20 parts of red peony root, 20 parts of white peony root, 20 parts of paeonol, 25 parts of angelica, 15 parts of Bupleurum, 20 parts of Atractylodes, licorice 8 servings, mint 15, rose 25, safflower 20, green calyx plum 20.

The raw materials are dried under the condition of 60 ° C for 6 hours, the raw materials are pulverized to 1000 mesh by the ultra-fine pulverization technology, the dextrin whose mass is 5% of the raw materials and the medicinal powder are mixed uniformly to make tablets, and after drying treatment, inspection and packaging, the obtained finished product.

Example 3

The present embodiment provides a traditional Chinese medicine composition for the treatment of chloasma, obtained by the following preparation method:

In parts by weight, weigh 8 parts of cinnamon sticks, 18 parts of Poria cocos, 8 parts of peach kernels, 18 parts of red peony root, 12 parts of white peony root, 18 parts of paeonol, 18 parts of angelica, 2 parts of Bupleurum, 12 parts of Atractylodes, licorice 2 parts, 12 parts mint, 22 parts rose flower, 18 parts safflower, 12 parts green calyx plum.

The raw materials were dried at 50° C. for 5 hours, and the raw materials were pulverized to 900 meshes by ultra-fine pulverization technology. The pulverized medicinal powder was leached once with 60% ethanol aqueous solution at 80°C under reflux for 6 hours each time. The multiple extracts were mixed and concentrated to dryness. The dried product is uniformly mixed with dextrin with a mass of 4% of the raw material to prepare a tablet, and the finished product is obtained after drying treatment, inspection and packaging.

Example 4

The present embodiment provides a traditional Chinese medicine composition for the treatment of chloasma, obtained by the following preparation method:

In parts by weight, weigh 12 parts of cinnamon sticks, 12 parts of Poria, 12 parts of peach kernels, 12 parts of red peony root, 12 parts of white peony root, 12 parts of paeonol, 18 parts of angelica, 12 parts of Bupleurum, 12 parts of Atractylodes, licorice 8 parts, 12 parts mint, 18 parts rose, 12 parts safflower, 12 parts green calyx plum.

The raw materials were dried at 55°C for 5 hours, and the raw materials were pulverized to 850 meshes by ultra-fine pulverization technology. The pulverized medicinal powder is extracted twice by refluxing the 50%-60% ethanol aqueous solution at 65° C. for 7 hours each time. The multiple extracts were mixed and concentrated to dryness. The dried product is uniformly mixed with dextrin whose mass is 2% of the raw material to make tablets, and the finished product is obtained after drying treatment, inspection and packaging.

Example 5

The present embodiment provides a traditional Chinese medicine composition for the treatment of chloasma, obtained by the following preparation method:

In parts by weight, weigh 10 parts of cinnamon sticks, 15 parts of Poria cocos, 10 parts of peach kernels, 15 parts of red peony root, 15 parts of white peony root, 15 parts of paeonol, 20 parts of angelica, 10 parts of Bupleurum, 15 parts of Atractylodes, licorice 5 parts, 10 parts mint, 20 parts rose flower, 12 parts safflower, 12 parts green calyx plum.

The raw materials are dried under the condition of 50 ° C for 5 hours, and the raw materials are pulverized to 900 mesh by the ultra-fine pulverization technology. finished product.

Comparative Example 1

The present comparative example provides a traditional Chinese medicine composition for the treatment of chloasma, obtained by the following preparation method:

In parts by weight, weigh 10 parts of cinnamon sticks, 15 parts of Poria cocos, 10 parts of peach kernels, 15 parts of red peony root, 15 parts of white peony root, 15 parts of paeonol, 20 parts of angelica, 10 parts of Bupleurum, 15 parts of Atractylodes, licorice 5 parts, 10 parts mint, 20 parts rose flower, 12 parts safflower, 12 parts green calyx plum.

Soak the raw materials in cold water for 30min;

After soaking, boil with strong fire, then decocted with slow fire for 35 minutes, and filter to obtain the first filtrate and medicinal residue;

The medicinal residues are added with water, boiled with high heat and then decocted with slow heat for 25 minutes, and filtered to obtain the second filtrate; the first filtrate and the second filtrate were combined.

Comparative Example 2

The present comparative example provides a traditional Chinese medicine composition for the treatment of chloasma, obtained by the following preparation method:

In parts by weight, weigh 10 parts of cinnamon sticks, 15 parts of Poria, 20 parts of Angelica sinensis, and 15 parts of Atractylodes Rhizoma.

The raw materials are dried under the condition of 50 ° C for 5 hours, and the raw materials are pulverized to 900 mesh by the ultra-fine pulverization technology. finished product.

test case clinical trial

1. Case selection

All the cases were from patients diagnosed with chloasma in a hospital. 210 patients were selected, all of them were female, aged 18-60 years old, without infection and not allergic to this drug. They were randomly divided into 7 groups with 30 patients in each group. There was no significant difference in the general data such as gender and disease stage among the groups (p>0.05).

2. Treatment

The patients in groups 1 to 7 took the traditional Chinese medicines provided in Examples 1 to 5 and Comparative Examples 1 and 2 orally respectively. Oral 3 times a day, 6 to 8 tablets each time, one course of treatment per month, 4 courses of treatment.

3. Efficacy criteria

Marked effect: The area of the stains is reduced by more than 60%, and the color is obviously lighter.

Improvement: The area of pigmentation spots disappeared by more than 30%, and the color became lighter.

Invalid: The subsided area of the color spot is less than 30%, and the color change is not obvious.

4. Results and Analysis

Table 1 Efficacy results table

group effective efficient invalid total efficiency Example 1 4 5 twenty one 30% Example 2 5 5 20 33.3% Example 3 5 4 twenty one 30% Example 4 5 5 20 33.3% Example 5 5 6 19 36.7% Comparative Example 1 6 5 19 36.7% Comparative Example 2 3 2 25 16.7%

It can be seen from Table 1 that the total effective rates of the traditional Chinese medicine compositions for the treatment of chloasma provided in Examples 1 to 5 and Comparative Example 1 are all high, indicating that they all have a good therapeutic effect on chloasma. After increasing the course of treatment, the total effective rate was higher. Compared with the formulations of Examples 1-5 and Comparative Example 1, the traditional Chinese medicine formula of Comparative Example 2 has fewer traditional Chinese medicines, and the efficacy is reduced and the effect is poor. Among them, the effect of the traditional Chinese medicine composition for treating chloasma provided in Example 5 and Comparative Example 1 is better, indicating that the formulation is reasonable and the preparation method is more scientific. The tablet provided in Example 5 is more convenient to carry and take than the decoction provided in Comparative Example 1.

Test case typical case

Fan Mou, female, 38 years old, farmer, has symmetrical chloasma on both cheeks for 3 years, usually manages farm work and tedious housework, has a irritable personality, often feels bitterness in the mouth and dry throat, and has light menstrual flow and blood clots. Give traditional Chinese medicine decoction: 10g cassia twig, 15g Poria, 10g peach kernel, 15g red peony, 15g white peony, 15g paeonol, 20g angelica, 10g Bupleurum, 15g Atractylodes, 5g licorice, 10g mint, 20g rose, 15g safflower , Green calyx plum 15g, 1 dose a day, and ask it to moisturize and sunscreen. After taking it for 10 days, the color of the chloasma was obviously lighter, the conscious temperament was calmer than before, and the mouth was bitter and dry and the throat was almost unnoticeable. Taking another 10 doses according to the original prescription, the spots and color are basically not obvious. It coincides with the menstrual cramps, and the amount is significantly increased compared with the previous one.

To sum up, the traditional Chinese medicine composition for the treatment of chloasma provided by the present invention has the functions of "soothing the liver and strengthening the spleen, relieving depression and lightening spots, promoting blood circulation and removing blood stasis", which can regulate the immunity of the body, improve blood circulation, and remove free radicals. It can inhibit the activity of tyrosinase, reduce the formation of melanin, lighten or subside melasma, improve the appearance of the skin, and improve the quality of life. At the same time, the prescription has a certain therapeutic effect on irritability and depression, dizziness and tinnitus, breast tenderness before menstruation, abdominal distention pain, light menstrual flow and other symptoms, as well as gynecological tumors or cysts. The prescription adopts natural Chinese herbal medicine as raw material, and has high safety performance and no toxic and side effects.

The above-described embodiments are some, but not all, embodiments of the present invention. The detailed descriptions of the embodiments of the invention are not intended to limit the scope of the invention as claimed, but are merely representative of selected embodiments of the invention. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

Claims (1)

1. The traditional Chinese medicine composition for treating chloasma is characterized by being mainly prepared from the following raw materials in parts by weight: 10 parts of cassia twig, 15 parts of poria cocos, 10 parts of peach kernel, 15 parts of red peony root, 15 parts of white peony root, 15 parts of cortex moutan, 20 parts of angelica sinensis, 10 parts of radix bupleuri, 15 parts of bighead atractylodes rhizome, 5 parts of liquorice, 10 parts of mint, 20 parts of rose, 12 parts of safflower and 12 parts of flos mume;

the preparation method of the traditional Chinese medicine composition for treating chloasma comprises the following steps: drying the raw materials for 5 hours at 50 ℃, crushing the raw materials to 900 meshes by adopting an ultramicro crushing technology, uniformly mixing dextrin with 3% of the mass of the raw materials and the medicinal powder to prepare tablets, drying, inspecting and packaging to obtain the finished product.