CN108261470A - A kind of peaceful prescription of brothers - Google Patents
A kind of peaceful prescription of brothers Download PDFInfo
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- CN108261470A CN108261470A CN201810076686.0A CN201810076686A CN108261470A CN 108261470 A CN108261470 A CN 108261470A CN 201810076686 A CN201810076686 A CN 201810076686A CN 108261470 A CN108261470 A CN 108261470A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/486—Millettia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/808—Scrophularia (figwort)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention provides a kind of peaceful prescriptions of brothers.The prescription is made of following raw materials：It is prepared by following component：30 60g of honeysuckle, 20 45g of radix scrophulariae, 20 45g of Radix Angelicae Sinensis, 20 45g of Caulis Spatholobi, 20 45g of caulis lonicerae, 20 45g of licorice.Include the following steps：Step 1：Above-mentioned medicinal material is mixed, the water of 8 times of weight is added to impregnate 2h, boils 1h；Step 2：It pours out liquid, then the boiling of 6 times of weight is added to boil 30 min, pour out liquid, merge to obtain the final product.The peaceful prescription of brothers of the invention is clearing heat and detoxicating, promoting blood circulation and stopping pain, for washout Chinese traditional treatment, can effectively treat because treating the hand-foot syndrome caused by chemotherapy.
Description
Technical field
The present invention relates to technical field of Chinese medicine, and in particular to a kind of peaceful prescription of brothers.
Background technology
Hand-foot syndrome is a kind of characteristic Skin toxicity；It is the chemotherapeutics such as capecitabine, 5 FU 5 fluorouracil
And the common adverse reactions of the targeted drugs such as Sorafenib, Sutent, and more often see in combined chemotherapy, incidence is high
Up to 60-90%, wherein 3 grades of incidences are about 17%.Hand-foot syndrome not only influences the daily life and action of patient, and interferes
Carrying out on time, according to quantity for treatment, finally influences chemotherapeutic efficacy.
Hand-foot syndrome is belonged to " heat toxin " scope by motherland's medicine according to main symptom, and clinical initial stage shows as palm, vola
The cacesthesia of finger/toe end（Tingling sensation, numbness）, congested, erythema, skin thickens, is coarse；Then occur pain, chap,
Furfur and decortication, severe patient may occur in which bubble, moist ulcer with severe pain, and majority shows as red tongue with yellowish fur, rapid pulse.Cause
Spleen injury after Chemotherapy in Patients, the biochemical weary source of qi and blood, ying blood flourish cannot be supported, essence and blood cannot sensible four limbs, limb end lost in moistening
It supports and shows as the cacesthesias such as skin pain, numbness；Long healthy tendency due to chemotherapy is damaged, chemotherapeutics and its metabolite product
Combinate form is into tangible heresy, and medicine poison is interior to be tied, and interior strongly fragrantization heat, excessive noxious heat compels the absurd row of blood, then, it is seen that affected part pain and swelling, erythema, water
Bubble, bleeding blister even fester.The card of asthenia in origin and asthenia in superficiality is formed, spleen deficiency is this, and heat toxin is mark." symptomatic treatment in acute condition, radical treatment in chronic case ", because
Heat toxin seriously affects chemotherapeutic efficacy, therefore can first control its mark, and because its site of pathological change table is shallow, is particularly suitable for controlling outside traditional Chinese medical science part.
External treatment of traditional Chinese medicine is one of traditional Chinese medical science traditional therapy, belongs to one kind of transdermal delivery system, and the mechanism of action is
Immersion is washed to the directly smoked of patients feet by liquid, nervus vasculairs is stimulated, improves pedal blood circulation and nerve conduction, so as to
It is recuperating qi-blood, dredging the channel, clearing heat and detoxicating, it quickly relieves symptoms, achievees the purpose that treatment.As《Li Yue Pianwen, Rhymed Discourse for Topical Remedies》Day：It " controls outside
Reason, i.e., the interior reason controlled, the medicine controlled outside, i.e., the interior medicine controlled, the different person's method ear of institute ", elaborate that disease is outer in external treatment of traditional Chinese medicine well
The principle controlled.
With the progress of oncology studies, capecitabine, Sorafenib etc. are widely used to clinic.It is integrated for brothers
The prevention or treatment of disease, it is clinical frequently with measure include：Excessive friction, compression and the local damage of brothers is avoided, dress is wide
It is loose comfortable, afflicted skin moistening is kept, using local topicals medicines such as urea frost, anti-oxidant ointment, dimethyl sulfoxide (DMSO), antiperspirant,
Oral vitamin B6, vitamin E, glucocorticoid, Celebrex, cox 2 inhibitor etc., but effect is not very notable.Still have 10%
Patient subtracts medicine due to 3 grades of hand-foot syndromes and is even discontinued, and seriously affects curative effect, reduces patient survival indirectly.Therefore, seek one
The new external treatment of tcm treatment hand-foot syndrome of kind is particularly important.
Invention content
Technical problems to be solved：The object of the present invention is to provide a kind of peaceful prescriptions of brothers, for washout Chinese traditional treatment, control
The hand-foot syndrome caused by chemotherapy is treated, mitigates its clinical symptoms so as to which chemotherapy be enable to carry out on time, according to quantity, the prescription heat-clearing solution
Poison, promoting blood circulation and stopping pain can be used for the treatment of hand-foot syndrome.
Technical solution：A kind of peaceful prescription of brothers, is prepared by following component：Honeysuckle 30-60g, radix scrophulariae 20-45g, when
Return 20-45g, Caulis Spatholobi 20-45g, caulis lonicerae 20-45g, licorice 20-45g.
It is further preferred that the peaceful prescription of a kind of brothers, is prepared by following component：Honeysuckle 60g, radix scrophulariae
30g, Radix Angelicae Sinensis 30g, Caulis Spatholobi 30g, caulis lonicerae 30g, licorice 30g.
The preparation method of the above-mentioned peaceful prescription of brothers includes the following steps：
Step 1：Above-mentioned medicinal material is mixed, the water of 8 times of weight is added to impregnate 2h, boils 1h；
Step 2：It pours out liquid, then the boiling of 6 times of weight is added to boil 30 min, pour out liquid, merge to obtain the final product.
A kind of preparation method of the peaceful prescription of brothers, can be prepared into granule by liquid.
It lives according to the historical records of Chinese medicine with modern pharmacology research, the Chinese medicine selected by the present invention with following pharmacology
Property and major function：Honeysuckle is sweet in flavor cold in nature in we, and especially kind clearing heat and detoxicating, dissipation carbuncle swells power is strong, to control wanting for heat toxin sore carbuncle
Medicine, the extract of honeysuckle can inhibit proinflammatory cytokine（IL-6, TNF-α and PGE2 and COX-2 enzymes etc.）Generation, and
It can inhibit the chemotactic of macrophage, reduce inflammation reaction, efficiently controls inflammation, therefore reuses as monarch.Radix scrophulariae sweetness and bitterness is salty and is slightly cold,
It is longer than clearing heat and cooling blood, purging intense heat and detonicating, iridoid compound therein has significant inhibiting effect to the activity of NF- κ B, has
Anti-inflammatory activity is shared with monarch drug in a prescription, not only the heat symptoms caused by an exopathgen of clear qi leel, but also the heat toxin of solution blood system, then clearing heat and detoxicating power writes especially, while also increases
Strong anti-inflammatory effect, is ministerial drug；Radix Angelicae Sinensis acrid-sweet flavor and gentle, nourshing blood and promoting blood circulation, both can the promoting flow of qi and blood circulation, stagnation resolvation promote blood circulation and relieve pain,
Again close radix scrophulariae nourishing the blood and yin and it is newborn, be altogether ministerial drug.And its active ingredient Coumarins perfume (or spice) by inhibit NO, NOS, TNF-α and
The expression of COX-2, equally with anti-inflammatory effect.Caulis Spatholobi bitter sweet and warm, promoting blood circulation and stopping pain, relaxing tendons and activating collaterals, cooperation Radix Angelicae Sinensis is to control blood
Void is unable to the extremity numbness of nourishing the muscle and tendon；Caulis lonicerae is equal with honeysuckle, can enhance the effect of honeysuckle is clearing heat and detoxicating, is all adjutant.
Two kinds of rattan class medicines can also relaxing tendons and activating collaterals, lead to regulating the qi flowing in the channels blood, make limb end blood fortune abundant, alleviate the discomforts such as numb pain.Radix Glycyrrhizae gives birth to
With, it is not only clearing heat and detoxicating, but also coordinating the drug actions of a prescription, help makes, and Radix Glycyrrhizae acids and Flavonoid substances energy antiulcer in Radix Glycyrrhizae for it.Six medicines
Clearing heat and detoxicating, the work(of promoting blood circulation and stopping pain is played altogether.
Advantageous effect：The peaceful prescription of brothers of the invention is clearing heat and detoxicating, promoting blood circulation and stopping pain, can effectively treat because treatment is because changing
Hand-foot syndrome caused by treatment.
Advantageous effect：The peaceful prescription of brothers of the invention is clearing heat and detoxicating, promoting blood circulation and stopping pain, can effectively treat because treatment is because changing
Hand-foot syndrome caused by treatment.We conducted small sample retrospective studies, and Buddhist nun is replaced to application Xeloda, Sorafenib and Ah pa
The 20 III degree hand-foot syndrome patients occurred afterwards, under the premise for the treatment of intensity is not changed, giving brothers, rather square lavipeditum is smoked to wash and is controlled
It treats, for high efficiency up to 90%, the average disease amelioration time is 6 days.And the present invention is prepared simplicity, was both kept away using external fumigation and washing mode
The sense of discomfort of patient's oral traditional Chinese medicine is exempted from, and has increased the drug absorption concentration of lesion part, made curative effect more notable.
Description of the drawings
Fig. 1 is that case 1 uses this prescription future trouble person's ulcer surface healing state photo.
Fig. 2 is that case 2 uses this prescription future trouble person's ulcer surface healing state photo.
Fig. 3 is the pretherapy and post-treatment TNF α relative expression quantity variation of hand-foot syndrome patient.
Specific embodiment
Embodiment 1
Clinical treatment case
A kind of peaceful prescription of brothers, is prepared by following component：Honeysuckle 60g, radix scrophulariae 30g, Radix Angelicae Sinensis 30g, Caulis Spatholobi 30g, bear
Winter rattan 30g, licorice 30g.
The preparation method of the above-mentioned peaceful prescription of brothers is：
Step 1：Above-mentioned medicinal material is mixed, the water of 8 times of weight is added to impregnate 2h, boils 1h；
Step 2：It pours out liquid, then the boiling of 6 times of weight is added to boil 30 min, pour out liquid, merge to obtain the final product.
Taking liquid 800ml is divided to two parts, every part of 400ml, and 400ml liquids are converted into 4000ml, are packed into foot care by point 2 uses
Bucket, 38-40 DEG C of foam washing of constant temperature, each 30min submerge affected part as possible, and point early, evening is twice.
Case 1
Patient, Mrs.Lu, female's property, 79 years old, Right-sided Colon Cancer was more than postoperative May.In 2017-06-10,07-01,07-22,08-15,
09-04,09-25 take orally capecitabine treatment.Left side suffering limb occurs the 3 of exanthemv when 2017-10-17 carrys out our hospital's outpatient clinic
Grade hand-foot syndrome, after hospitalize and be admitted to hospital.
A acquires serum after being admitted to hospital.
B continues oral capecitabine, and combines brothers rather square morning and evening foam washing brothers twice, submerge affected part.
C photographs to record patient's ulcer surface healing state（Fig. 1）.
D acquires serum again using brothers rather square foam washing after six days.
As a result：0th day, illing skin had moist ulcer and with pain, is classified as 3 grades；It treats the 2nd day, affected part is moist to burst
Ulcer face is healed, and without apparent sepage, pain relief is classified as 2 grades；It treats the 6th day, illing skin incrustation, without pain is classified as 0-
1 grade.
Case 2
Patient, Shen XX, women, 78 years old, " ovarian cancer post operation more than 17 years, posterior peritoneum shifted 6 years, left clavicle superior gluteal lymph node transfer 2
Year ", patient starts oral Ah pa for Buddhist nun's targeted therapy in 2017-03-17,3 grades of hand-foot syndromes, vola occurs after treating March
Bubble ulceration, pain is so that influence patient's normal walking.Carry out our hospital's outpatient clinic in 2017-06-20, brothers given rather just to treat,
It is constant to target pharmaceutical quantities simultaneously.
A outpatient services acquire serum.
B continues oral Ah pa for Buddhist nun, and combines brothers rather square morning and evening foam washing brothers twice, submerge affected part.
C photographs to record patient's ulcer surface healing state（Fig. 2）.
As a result：0th day, there was bubble in affected part and ulceration is with severe pain, influences patient's walking, is classified as 3 grades；Treat the 6th
My god, affected part bubble absorbs, pain relief, and the walking as usual of patient's energy is classified as 0-1 grades.
Claims (4)
1. a kind of peaceful prescription of brothers, it is characterised in that：It is prepared by following component：Honeysuckle 30-60g, radix scrophulariae 20-45g, when
Return 20-45g, Caulis Spatholobi 20-45g, caulis lonicerae 20-45g, licorice 20-45g.
2. a kind of peaceful prescription of brothers according to claim 1, it is characterised in that：It is prepared by following component：Honeysuckle
60g, radix scrophulariae 30g, Radix Angelicae Sinensis 30g, Caulis Spatholobi 30g, caulis lonicerae 30g, licorice 30g.
3. a kind of preparation method of the peaceful prescription of brothers of claim 1 to 2 any one of them, it is characterised in that：Including following step
Suddenly：
Step 1：Above-mentioned medicinal material is mixed, the water of 8 times of weight is added to impregnate 2h, boils 1h；
Step 2：It pours out liquid, then the boiling of 6 times of weight is added to boil 30 min, pour out liquid, merge to obtain the final product.
4. a kind of preparation method of the peaceful prescription of brothers according to claim 3, it is characterised in that：Liquid can be prepared into
Granula.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810076686.0A CN108261470A (en) | 2018-01-26 | 2018-01-26 | A kind of peaceful prescription of brothers |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810076686.0A CN108261470A (en) | 2018-01-26 | 2018-01-26 | A kind of peaceful prescription of brothers |
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| CN108261470A true CN108261470A (en) | 2018-07-10 |
Family
ID=62776907
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| CN201810076686.0A Pending CN108261470A (en) | 2018-01-26 | 2018-01-26 | A kind of peaceful prescription of brothers |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109223859A (en) * | 2018-11-15 | 2019-01-18 | 北京大学深圳医院 | Pharmaceutical composition, drug and its application |
| CN111789895A (en) * | 2019-04-08 | 2020-10-20 | 中日友好医院 | External traditional Chinese medicine composition for treating hand-foot skin reaction |
| CN116173115A (en) * | 2023-03-20 | 2023-05-30 | 北京中医药大学东直门医院 | Traditional Chinese medicine composition containing honeysuckle stem, application and preparation thereof |
| CN116585401A (en) * | 2023-04-20 | 2023-08-15 | 黄石燕舞药业有限公司 | Analgesic paste for promoting blood circulation to remove blood stasis and preparation method thereof |
| CN116870072A (en) * | 2023-08-03 | 2023-10-13 | 华中科技大学同济医学院附属同济医院 | Traditional Chinese medicine composition, application, gel and preparation method of gel |
-
2018
- 2018-01-26 CN CN201810076686.0A patent/CN108261470A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109223859A (en) * | 2018-11-15 | 2019-01-18 | 北京大学深圳医院 | Pharmaceutical composition, drug and its application |
| CN111789895A (en) * | 2019-04-08 | 2020-10-20 | 中日友好医院 | External traditional Chinese medicine composition for treating hand-foot skin reaction |
| CN111789895B (en) * | 2019-04-08 | 2022-02-11 | 中日友好医院 | External traditional Chinese medicine composition for treating hand-foot skin reaction |
| CN116173115A (en) * | 2023-03-20 | 2023-05-30 | 北京中医药大学东直门医院 | Traditional Chinese medicine composition containing honeysuckle stem, application and preparation thereof |
| CN116585401A (en) * | 2023-04-20 | 2023-08-15 | 黄石燕舞药业有限公司 | Analgesic paste for promoting blood circulation to remove blood stasis and preparation method thereof |
| CN116585401B (en) * | 2023-04-20 | 2024-01-12 | 黄石燕舞药业有限公司 | Analgesic paste for promoting blood circulation to remove blood stasis and preparation method thereof |
| CN116870072A (en) * | 2023-08-03 | 2023-10-13 | 华中科技大学同济医学院附属同济医院 | Traditional Chinese medicine composition, application, gel and preparation method of gel |
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Application publication date: 20180710 |