CN101143171B - Traditional Chinese medicine and its preparation method and its application - Google Patents
Traditional Chinese medicine and its preparation method and its application Download PDFInfo
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- CN101143171B CN101143171B CN2007100453603A CN200710045360A CN101143171B CN 101143171 B CN101143171 B CN 101143171B CN 2007100453603 A CN2007100453603 A CN 2007100453603A CN 200710045360 A CN200710045360 A CN 200710045360A CN 101143171 B CN101143171 B CN 101143171B
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Abstract
The invention relates to the technical field of traditional Chinese medicine and concretely relates to a drug of traditional Chinese medicine for remedying skin disease and the preparation method and application of the drug. The drug of the invention is prepared by the raw materials of a rhubarb, a dried tangerine peel, a liquorice and a coptis chinensis. The drugs of the raw materials have good curative effect within the following weight range of 3 to 6 portions of the rhubarbs, 2 to 5 portions of the dried tangerine peels, 3 to 6 portions of the liquorice and 1 to 5 portions of the coptis chinensis. The drug of the invention has the functions of clearing heat and toxin, clearing fire, cooling blood, activating blood, dispersing tiredness, detumescence, acesodyne, removing putrefaction, generating muscle, diminishing inflammation and resisting bacteria and is used for remedying the furuncle, the carbuncle, the honeycomb-shaped tissue inflammation, the acne, the bedsore, the boil, theeczema, the strip-shaped herpes, the simplex herpes and the burn and scald with significant curative effect.
Description
Technical field
The present invention relates to technical field of Chinese medicines, be specifically related to the dermopathic Chinese medicine medicine of a kind of treatment, its preparation method and application thereof.
Background technology
Dermatosis is one of common disease, and especially seat skin ulcer, eczema, decubital ulcer, dermatitis, banded scar rash, burn and scald be clinical comparatively common, and these sick kinds are in adopting clinically, western medical treatment all obtains curative effect preferably.For a long time, the medical personnel makes every effort to explore a kind of bacillary and medicine viral dermatosis of can treating. the medicine of disclosed treatment various skin disease in patent documentation, in CN1621074A application part, the dermopathic medicine of treatment is described as Hu Xiangren, can treat dermatitis, decubital ulcer, burn and scald, only limit to treat bacterial dermatosis, do not relate to the treatment of viral dermatosis, as banded lump rash, simple property scar rash.Clinically and the patient still have demand to can effectively treating bacillary and medicine viral dermatosis.
Summary of the invention
The object of the invention is to provide a kind of and can effectively treats bacillary and Chinese medicine medicine viral dermatosis.
Another object of the present invention has provided the preparation method of this medicine.
Medicine of the present invention is that feedstock production forms by Radix Et Rhizoma Rhei, Pericarpium Citri Reticulatae, Radix Glycyrrhizae, Rhizoma Coptidis, and crude drug has better curative effect in the following weight parts scope: Radix Et Rhizoma Rhei 3-6 part, Pericarpium Citri Reticulatae 2-5 part, Rhizoma Coptidis 3-6 part, Radix Glycyrrhizae 1-5 part.
Be preferably: 5 parts of Radix Et Rhizoma Rhei, 3 parts of Pericarpium Citri Reticulataes, 5 parts of Rhizoma Coptidis, 3 parts in Radix Glycyrrhizae.
For improving curative effect, can also add flavor medicines such as Rhizoma Polygoni Cuspidati, Fructus Gardeniae, Cortex Phellodendri, Caulis Sargentodoxae, Flos Chrysanthemi.
Medicine material survival dose of the present invention can also be: Radix Et Rhizoma Rhei 3-6 part, Pericarpium Citri Reticulatae 2-5 part, Rhizoma Coptidis 3-6 part, Radix Glycyrrhizae 1-5 part, Rhizoma Polygoni Cuspidati 1-3 part.
Be preferably: 5 parts of Radix Et Rhizoma Rhei, 3 parts of Pericarpium Citri Reticulataes, 5 parts of Rhizoma Coptidis, 3 parts in Radix Glycyrrhizae, 1 part of Rhizoma Polygoni Cuspidati.
Medicine material survival dose of the present invention can also be: Radix Et Rhizoma Rhei 3-6 part, Pericarpium Citri Reticulatae 2-5 part, Rhizoma Coptidis 3-6 part, Radix Glycyrrhizae 1-5 part, Rhizoma Polygoni Cuspidati 1-3 part, Flos Chrysanthemi 2-4 part, Fructus Gardeniae 1-3 part, Cortex Phellodendri 1-3 part, Caulis Sargentodoxae 1-4 part.
Be preferably: 5 parts of Radix Et Rhizoma Rhei, 3 parts of Pericarpium Citri Reticulataes, 5 parts of Rhizoma Coptidis, 3 parts in Radix Glycyrrhizae, 1 part of Rhizoma Polygoni Cuspidati, 2 parts of Flos Chrysanthemis, 1 part of Fructus Gardeniae, 2 parts of Cortex Phellodendris, 1 part of Caulis Sargentodoxae.
Wherein selecting Rhizoma Coptidis, Radix Et Rhizoma Rhei for use is because of Rhizoma Coptidis nature and flavor bitter cold, heat clearing and damp drying, eliminating fire and detoxication, treat sore, modern pharmacological research confirms that Rhizoma Coptidis has antibiotic, antifungal, antivirus action has stronger inhibitory action to 7 kinds of gram negative bacterias and 5 kinds of gram positive bacterias; Radix Et Rhizoma Rhei, the nature and flavor bitter cold, clearing away heat-fire, promoting blood circulation and detoxication stimulates the menstrual flow by addiction, treats carbuncle and treats skin ulcer, has clearing away heat-fire, the addiction dual function of dispelling of invigorating blood circulation, Radix Et Rhizoma Rhei are purgatives medicine (expelling the heat-evil), the product of compatibility clearing away heat-fire (Rhizoma Coptidis) clearly down and usefulness, to strengthen the effect of heat clearing away.Radix Glycyrrhizae property is sweet, flat, goes into liver, spleen, lung meridian, and its energy coordinating the actions of various ingredients in a prescription cures mainly vital organs of the human body cold and heat pathogen, infirmities and diseases, can lung moistening detoxifcation and middle emergency.The effect of Radix Glycyrrhizae is very extensive, mainly contains effects such as antiinflammatory, antiallergic action, convulsion, antitumor, analgesia, diuresis.Pericarpium Citri Reticulatae is warm in nature, bitter in the mouth, suffering.Regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.Be used for fullness in the epigastrium and chest, lack of appetite and vomiting, cough ant phlegm.
In order to reach better therapeutic, medicine of the present invention also makes up with Flos Chrysanthemi, Rhizoma Polygoni Cuspidati, Fructus Gardeniae, Cortex Phellodendri, Caulis Sargentodoxae.Select for use Flos Chrysanthemi to be because Flos Chrysanthemi is sweet, flavor is cold, have the effect that diffusing wind heat, suppressing the hyperactive liver make eye bright.Select Rhizoma Polygoni Cuspidati, the property mildly bitter flavor, be slightly cold, expelling wind and removing dampness, the tired analgesic therapy of loosing is used for carbuncle sore tumefacting virus, burn and scald.Modern pharmacological research confirms that Rhizoma Polygoni Cuspidati has antibiotic, antiviral and antipyretic effect.Fructus Gardeniae, the nature and flavor bitter cold has heat-clearing and toxic substances removing, and the merit of purging fire and cooling blood is used for pathogenic fire,toxin and furuncles, and the pain of injury swells and ache.Cortex Phellodendri, the nature and flavor bitter cold, heat clearing and damp drying, pathogenic fire purging removes steams, and skin ulcer is treated in detoxifcation.Be used for sore swollen toxin, eczema expectorant is itched.Modern pharmacological research confirms that Cortex Phellodendri has antibiotic antiulcer action.Caulis Sargentodoxae, nature and flavor are bitter flat, and heat-clearing and toxic substances removing is arranged, and the merit of the diffusing addiction pain relieving of invigorating blood circulation is used for pathopyretic ulcer.Above four Chinese medicine helps the monarch and his subjects' product heat-clearing and toxic substances removing altogether, purging fire and cooling blood, the merit of addiction of loosing of invigorating blood circulation.
Medicine of the present invention adopts the preparation method of Chinese medicine preparation to make any conventional external preparation, the unmixed unguentum, water preparation, oil preparation, paste, powder evenly made of for example these crude drug can being pulverized uses, but in order to make these crude drug bring into play its drug effect better, the preparation method of preferred active constituent of the present invention is as follows:
A) it is standby to take by weighing each crude drug Radix Et Rhizoma Rhei, Pericarpium Citri Reticulatae, Rhizoma Coptidis, Radix Glycyrrhizae according to weight proportion:
B) above-mentioned Radix Et Rhizoma Rhei, Pericarpium Citri Reticulatae, Rhizoma Coptidis, Radix Glycyrrhizae water are decocted 2 times, each 1.5 hours, merge decoction liquor twice, be condensed into thick paste after the filtration, dry under 45-50 ℃ of temperature, make dry extract I;
C) medicinal residues after will decocting merge extracted twice liquid with alcohol reflux 2 times, filter the back and reclaim ethanol and also be condensed into thick paste, and are dry under 45-50 ℃ of temperature, make dry extract II;
D) merge dry extract I and II, it is ground into powder, just made the active constituent of medicine of the present invention;
If also with Rhizoma Polygoni Cuspidati, Flos Chrysanthemi, Fructus Gardeniae, Cortex Phellodendri, Caulis Sargentodoxae combination, its preparation method is:
A) it is standby to take by weighing each crude drug Flos Chrysanthemi, Radix Et Rhizoma Rhei, Pericarpium Citri Reticulatae, Rhizoma Coptidis, Radix Glycyrrhizae, Rhizoma Polygoni Cuspidati, Fructus Gardeniae, Cortex Phellodendri, Caulis Sargentodoxae according to the weight proportion of prescription;
B) above-mentioned Flos Chrysanthemi, Radix Et Rhizoma Rhei, Pericarpium Citri Reticulatae, Rhizoma Coptidis, Radix Glycyrrhizae, Rhizoma Polygoni Cuspidati, Fructus Gardeniae, Cortex Phellodendri, Caulis Sargentodoxae water are decocted 2 times, each 1.5 hours, merge decoction liquor twice, make dry extract M;
C) medicinal residues after will decocting merge extracted twice liquid with alcohol reflux 2 times, filter the back and reclaim ethanol and also be condensed into thick paste, and are dry under 45-50 ℃ of temperature, make dry extract W;
D) merge dry extract M and W, it is ground into powder, just make the active constituent of medicine of the present invention.
The active constituent of medicine of the present invention can add various adjuvants required when putting into the different exterior-applied formulation of preparation, be prepared into any exterior-applied formulation commonly used as vaseline, lanoline, Oleum Sesami, vegetable oil, liquid paraffin, aquae destillata, glycerol etc. with the Chinese medicine preparation of routine, as powder, water preparation, unguentum, paste, Emulsion, tincture.
Medicine of the present invention has heat-clearing and toxic substances removing, purging fire and cooling blood, tired, the reducing swelling and alleviating pain that looses of invigorating blood circulation, putrefaction-removing granulation-promoting, the function of antiphlogistic antibacterial, antiviral is used for the treatment of furuncle, carbuncle, honeycomb sex organization inflammation, seat skin ulcer, decubital ulcer, furuncle, eczema, dermatitis, banded scar rash, simple property strategic point rash and burn and scald.
The specific embodiment
Below in conjunction with specific embodiment, further illustrate the present invention.Should be understood that these embodiment only to be used to the present invention is described and be not used in and limit the scope of the invention.Further specify the beneficial effect of medicine of the present invention by clinical trial statistics and model case.
Embodiment 1: the water preparation preparation of medicine of the present invention
A) take by weighing Radix Et Rhizoma Rhei 50g, Pericarpium Citri Reticulatae 30g, Rhizoma Coptidis 50g, Radix Glycyrrhizae 30g, decoct with water 2 times, each 1.5 hours, merge decocting liquid twice, be condensed into thick paste after the filtration, dry under 45-50 ℃, make dry extract;
B) will decoct the back medicinal residues and carry out reflux, extract, 2 times with ethanol, each 2 hours, merge extracted twice liquid, filter, reclaim ethanol and be condensed into thick paste, dry under 45-50 ℃, make dry extract II,
C) merge dry extract I and II, it is ground into powder, just made the active constituent of medicine of the present invention;
D) the pharmaceutically active component with said extracted adds aquae destillata by 1: 200 weight ratio, adds 10% glycerol again, makes water preparation.
Embodiment 2: the unguentum preparation of medicine of the present invention
A) take by weighing Radix Et Rhizoma Rhei 50g, Pericarpium Citri Reticulatae 30g, Rhizoma Coptidis 50g, Radix Glycyrrhizae 30g, Rhizoma Polygoni Cuspidati 10g, decoct with water 2 times, each 1 hour, be condensed into thick paste after the filtration, dry under 45-50 ℃, make dry extract;
B) will decoct the back medicinal residues and carry out reflux, extract, 2 times with ethanol, each 2 hours, merge extracted twice liquid, filter, reclaim ethanol and be condensed into thick paste, dry under 45-50 ℃, make dry extract II;
C) merge dry extract I and II, it is ground into powder, just made the active constituent of medicine of the present invention;
D) the pharmaceutically active component with said extracted adds vaseline 200g, lanoline 2g, behind the mix homogeneously, makes unguentum.
Embodiment 3: the paste preparation of medicine of the present invention
A) take by weighing Radix Et Rhizoma Rhei 50g, Pericarpium Citri Reticulatae 30g, Rhizoma Coptidis 50g, Radix Glycyrrhizae 30g, Rhizoma Polygoni Cuspidati 10g, Flos Chrysanthemi 20g, Fructus Gardeniae 10g, Cortex Phellodendri 20g, Caulis Sargentodoxae 10g, decoct with water 2 times, each 1.5 hours, merge decocting liquid twice, be condensed into thick paste after the filtration, dry under 45-50 ℃, make dry extract I;
B) will decoct the back medicinal residues and carry out reflux, extract, 2 times with ethanol, each 2 hours, merge extracted twice liquid, filter, reclaim ethanol and be condensed into thick paste, dry under 45-50 ℃, make dry extract II;
C) merge dry extract I and II, it is ground into powder, just made the active constituent of medicine of the present invention;
D) the pharmaceutically active component with said extracted adds vaseline 200g, glycerol 20g, Pulvis Talci 50g, makes paste behind the mix homogeneously.
Embodiment 4
With the water preparation of embodiment 1 preparation,, show that coating just has improvement in one day through 100 many cases mosquito bite and insect bite infection, eczema, measles patient's clinical treatment, 1-2 week also can fully recover, and by statistics, that obtains significant curative effect accounts for 75%, substantially effectively account for 95%, invalid accounts for 2%, and total effective rate reaches 98%.
With the unguentum of embodiment 2 preparation, through 80 many cases furuncle, carbuncle, the scorching patient's of honeycomb sex organization clinical treatment, show that coating just has improvement in 2 days, 2-3 week also can fully recover, and by statistics, that obtains significant curative effect accounts for 70%, substantially effectively accounts for 96%.
With the paste of embodiment 3 preparations, through the clinical observation of 188 routine systems, the his-and-hers watches skin lesion is hindered the patient, and one day wound surface of coating can be fully recovered; Two degree also can be fully recovered in skin injury coating 1-2 week; To antiinflammatory, promoting healing effects such as large tracts of land burn and scald, decubital ulcers, curative effect all be better than with chloromycetin, etc. matched group; In addition to diabetes, tumor patient with significant curative effect is also arranged because of skin infection of weak difficult healing etc.By statistics, that obtains significant curative effect accounts for 52%, substantially effectively accounts for 46%, and total effective rate reaches 95%.
All quote in this application as a reference at all documents that the present invention mentions, just quoted as a reference separately as each piece document.Should be understood that in addition those skilled in the art can make various changes or modifications the present invention after having read above-mentioned teachings of the present invention, these equivalent form of values fall within the application's appended claims institute restricted portion equally.
Claims (9)
1. the dermopathic Chinese medicine medicine of treatment is characterized in that it is made by following bulk drugs: Radix Et Rhizoma Rhei 3-6 part, Pericarpium Citri Reticulatae 2-5 part, Rhizoma Coptidis 3-6 part and Radix Glycyrrhizae 1-5 part.
2. the dermopathic Chinese medicine medicine of treatment according to claim 1, wherein the consumption of each crude drug is: 5 parts of Radix Et Rhizoma Rhei, 3 parts of Pericarpium Citri Reticulataes, 5 parts of Rhizoma Coptidis, 3 parts in Radix Glycyrrhizae.
3. one kind as the dermopathic Chinese medicine medicine of treatment is characterized in that it is made by following bulk drugs: Radix Et Rhizoma Rhei 3-6 part, Pericarpium Citri Reticulatae 2-5 part, Rhizoma Coptidis 3-6 part, Radix Glycyrrhizae 1-5 part and Rhizoma Polygoni Cuspidati 1-3 part.
4. the dermopathic Chinese medicine medicine of treatment according to claim 3, wherein the consumption of each crude drug is: 5 parts of Radix Et Rhizoma Rhei, 3 parts of Pericarpium Citri Reticulataes, 5 parts of Rhizoma Coptidis, 3 parts in Radix Glycyrrhizae, 1 part of Rhizoma Polygoni Cuspidati.
One kind as the treatment dermopathic Chinese medicine medicine, it is characterized in that it is made by following bulk drugs: Radix Et Rhizoma Rhei 3-6 part, Pericarpium Citri Reticulatae 2-5 part, Rhizoma Coptidis 3-6 part, Radix Glycyrrhizae 1-5 part, Rhizoma Polygoni Cuspidati 1-3 part, Flos Chrysanthemi 2-4 part, Fructus Gardeniae 1-3 part, Cortex Phellodendri 1-3 part, Caulis Sargentodoxae 1-4 part.
6. the dermopathic Chinese medicine medicine of treatment according to claim 5, wherein the consumption of each crude drug is: 5 parts of Radix Et Rhizoma Rhei, 3 parts of Pericarpium Citri Reticulataes, 5 parts of Rhizoma Coptidis, 3 parts in Radix Glycyrrhizae, 1 part of Rhizoma Polygoni Cuspidati, 2 parts of Flos Chrysanthemis, 1 part of Fructus Gardeniae, 2 parts of Cortex Phellodendris, 1 part of Caulis Sargentodoxae.
Claim 1-6 each treat the preparation method of dermopathic Chinese medicine medicine, it is standby that it comprises the following steps: a) to take by weighing each crude drug according to weight proportion;
B) above-mentioned crude drug water is decocted 2 times, each 1.5 hours, merge decoction liquor twice, be condensed into thick paste after the filtration, dry under 45-50 ℃ of temperature, make dry extract I;
C) medicinal residues after will decocting merge extracted twice liquid with alcohol reflux 2 times, filter the back and reclaim ethanol and also be condensed into thick paste, and are dry under 45-50 ℃ of temperature, make dry extract II;
D) merge dry extract I and II, it is ground into powder, just made the active constituent of described Chinese medicine medicine.
Claim 1-6 each treat application in the medicine of dermopathic Chinese medicine medicine in preparation treatment skin diseases.
Claim 1-6 each treat dermopathic Chinese medicine medicine and can be powder, water preparation, unguentum, paste, Emulsion or ingredients.
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102366486B (en) * | 2011-11-04 | 2013-05-01 | 刘百祥 | Traditional Chinese medicine for treating acne and preparation method thereof |
| CN103211897B (en) * | 2013-05-07 | 2014-06-25 | 张火根 | Medicament for treating burns and scalds |
| CN105381366A (en) * | 2015-12-18 | 2016-03-09 | 杜克花 | Traditional Chinese medicine composition for treating bedsores and preparing method thereof |
| CN112274570A (en) * | 2019-07-10 | 2021-01-29 | 阮安民 | Pure traditional Chinese medicine acne removing cream and preparation method thereof |
| CN111789791A (en) * | 2020-08-20 | 2020-10-20 | 广州荃智美肤生物科技研究院有限公司 | Skin care composition for infants and application thereof in cosmetics |
| CN111991528A (en) * | 2020-09-27 | 2020-11-27 | 王怀光 | A medicine for treating burn and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1334119A (en) * | 2001-07-26 | 2002-02-06 | 王继平 | Litholysizing bear gall powder |
| CN1895419A (en) * | 2006-06-16 | 2007-01-17 | 天津生机集团有限公司 | Multiple Chinese-medicinal prescription for aquatic cultivation |
| CN100998843A (en) * | 2007-01-15 | 2007-07-18 | 曹国胜 | Medicinal composition for treating cholecystitis |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1334119A (en) * | 2001-07-26 | 2002-02-06 | 王继平 | Litholysizing bear gall powder |
| CN1895419A (en) * | 2006-06-16 | 2007-01-17 | 天津生机集团有限公司 | Multiple Chinese-medicinal prescription for aquatic cultivation |
| CN100998843A (en) * | 2007-01-15 | 2007-07-18 | 曹国胜 | Medicinal composition for treating cholecystitis |
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