CN105381366A - Traditional Chinese medicine composition for treating bedsores and preparing method thereof - Google Patents

Traditional Chinese medicine composition for treating bedsores and preparing method thereof Download PDF

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Publication number
CN105381366A
CN105381366A CN201510963128.2A CN201510963128A CN105381366A CN 105381366 A CN105381366 A CN 105381366A CN 201510963128 A CN201510963128 A CN 201510963128A CN 105381366 A CN105381366 A CN 105381366A
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parts
radix
grams
rhizoma
powder
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杜克花
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Individual
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/26—Iron; Compounds thereof
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    • A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
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Abstract

The invention provides a traditional Chinese medicine composition for treating bedsores and a preparing method thereof. Ointment is prepared from radix astragali, radix angelica sinensis, rheum officinale, wild chrysanthemums, sophora flavescens, thunberg fritillary bulb and the like, aerosol is prepared from ajuga pantantha, galangal, geranium wilfordii and the like. In the using process, conventional debridement is carried out, after necrotic tissue is cleared, the aerosol is uniformly sprayed on the whole wound surface, after airing, the whole wound surface is smeared with the ointment, the aerosol is sprayed on the surface of the ointment, finally a wound is bound up with sterile gauze, and the dressing is changed once a day. The traditional Chinese medicine composition has the functions of promoting blood circulation, tonifying qi, promoting tissue regeneration, improving microcirculation of the wound surface, accelerating lesion tissue repair and enhancing the organism immune function and is capable of promoting angiogenesis, growth of granulation tissue and repair of wound surface tissue.

Description

A kind of Chinese medicine composition for the treatment of decubital ulcer and preparation method thereof
Technical field
The present invention relates to a kind of Chinese medicine composition for the treatment of decubital ulcer and preparation method thereof, belong to traditional Chinese medicine field.
Background technology
Decubital ulcer has another name called " bed-sore ", names because of the raw skin ulcer of seat cotton-padded mattress of a specified duration.Be more common in the patient of the long-term beds such as stupor, hemiplegia or lower extremity paralysis.Be apt to occur in the part easily suffering oppression and rub, as places such as tail sacrum, back, ischial tuberosity, heels.This disease does not rise due to long-term bed, prolonged illness deficiency of qi and blood; Multiple lose in circulation because of pressurized position QI and blood, can not nutrition skin, the broken sentimental dye of friction, causes necrosis to fester.
Clinical manifestation, from the beginning of time many on the skin at the positions such as tail sacrum, ridge, heel, ischial tuberosity, have a damaged face, or be a little brown erythema; Form black crust lid gradually, the skin-color of its surrounding is dark red, lack gloss and elasticity, finally burst rotten, form the shallow table ulcer of limitation, the flat undiscipline of collapsing of swollen gesture, slough difficult drop-off, pus is few, not easily restrains, the conscious pain had, have not bitterly.Now answer active treatment, avoid pressurized again, allow downright bad slough be separated with normal skin and flesh and to come off, surrounding swells gesture gradually limit office, and color and luster is red work by dark lag switch, and prognosis is better, and multipotency is cured.If the black corruption of ulcer spreads incessantly, swollen gesture continues development, and open sore part surrounding forms ghost, then prognosis is poor for a long time, and with lethargy, and Mental fatigue asthenia, diet such as not to think at the General Symptoms.With the passing of time, muscle of often causing injury damages bone, prognosis mala in routed corruption.
Often curative effect is not good enough for this sick western medical treatment, there is no desirable Therapeutic Method both at home and abroad.
Summary of the invention
The present invention is directed to the deficiency that existing treatment by Chinese herbs decubital ulcer exists, provide a kind of Chinese medicine composition for the treatment of decubital ulcer and preparation method thereof, for each phase decubital ulcer, clinical instant effect, cure time is short, and no pain has no side effect.
Technical solution of the present invention is as follows: a kind of Chinese medicine composition for the treatment of decubital ulcer, comprises the crude drug of following component by weight:
Component one: Radix Astragali 10-30 part, Radix Angelicae Sinensis 10-30 part, Radix Et Rhizoma Rhei 20-30 part, Flos Chrysanthemi Indici 10-20 part, Radix Sophorae Flavescentis 10-20 part, Bulbus Fritillariae Thunbergii 5-10 part, Radix Arnebiae (Radix Lithospermi) 10-20 part, Flos Carthami 10-20 part, Galla Chinensis 5-10 part, succinum 1-3 part, Indigo Naturalis 3-5 part, Os Draconis 5-10 part, Halloysitum Rubrum 9-12 part, Lasiosphaera Seu Calvatia 10-15 part, Sanguis Draxonis 10-15 part, catechu 10-15 part, careless imperial 10-15 part, Fructus Gardeniae 5-10 part, Margarita 1-3 part, Borneolum Syntheticum 1-3 part, Aloe 1-3 part;
Component two: Herba boeae clarkeanae 10-15 part, Rhizoma Alpiniae Officinarum 3-6 part, Herba Erodii 9-15 part, Radix Notoginseng 9-15 part, Rhizoma Dioscoreae Nipponicae 3-9 part, Radix Alangii 5-10 part, Caulis Piperis Kadsurae 6-12 part, Ramulus et Folium Bauhiniae Faberi 10-20 part, root of subprostrate sophora 5-10 part, Rhizoma Coptidis 10-30 part, Cortex Phellodendri 10-30 part, Nidus Vespae 10-15 part, Rhizoma Polygoni Cuspidati 10-15 part, Radix Glycyrrhizae 10-20 part.
Preferably, a kind of Chinese medicine composition for the treatment of decubital ulcer of the present invention, comprises the crude drug of following component by weight:
Component one: the Radix Astragali 20 parts, Radix Angelicae Sinensis 20 parts, Radix Et Rhizoma Rhei 25 parts, Flos Chrysanthemi Indici 15 parts, Radix Sophorae Flavescentis 15 parts, Bulbus Fritillariae Thunbergii 6 parts, Radix Arnebiae (Radix Lithospermi) 15 parts, 15 parts, Flos Carthami, Galla Chinensis 8 parts, succinum 2 parts, Indigo Naturalis 4 parts, Os Draconis 8 parts, Halloysitum Rubrum 10 parts, Lasiosphaera Seu Calvatia 12 parts, Sanguis Draxonis 12 parts, 12 parts, catechu, grass dragon 12 parts, Fructus Gardeniae 8 parts, Margarita 2 parts, Borneolum Syntheticum 2 parts, Aloe 2 parts;
Component two: Herba boeae clarkeanae 12 parts, Rhizoma Alpiniae Officinarum 5 parts, Herba Erodii 12 parts, Radix Notoginseng 12 parts, Rhizoma Dioscoreae Nipponicae 6 parts, Radix Alangii 8 parts, Caulis Piperis Kadsurae 10 parts, Ramulus et Folium Bauhiniae Faberi 15 parts, root of subprostrate sophora 8 parts, Rhizoma Coptidis 20 parts, Cortex Phellodendri 20 parts, Nidus Vespae 12 parts, Rhizoma Polygoni Cuspidati 12 parts, 15 parts, Radix Glycyrrhizae.
Described component one is prepared into external application paste, and method is as follows:
(1) take the Radix Astragali by recipe quantity, Radix Angelicae Sinensis, Radix Et Rhizoma Rhei, Radix Sophorae Flavescentis, Radix Arnebiae (Radix Lithospermi), Flos Chrysanthemi Indici, Fructus Gardeniae be ground into coarse powder, cross 60 mesh sieves, drop in extraction pot.Add the water of 7 times amount, circumfluence distillation 2 hours, carries 3 times altogether at every turn.Merge the extracting solution of 3 times, filter, be concentrated into 1:1.Add 95% ethanol in concentrated solution, leave standstill 24 hours, centrifugal, be precipitated as crude extract.Extract is dry with vacuum drying oven, namely obtains drug extract powder for subsequent use after micronizing;
(2) take the superfine powder such as Bulbus Fritillariae Thunbergii, Galla Chinensis, succinum, Indigo Naturalis, Os Draconis, Halloysitum Rubrum, Lasiosphaera Seu Calvatia, Sanguis Draxonis, catechu, grass dragon, Margarita, Borneolum Syntheticum, Aloe by recipe quantity and be broken into fine powder, powder footpath is 5-10 μm;
(3) the drug extract powder of above-mentioned (1) is added appropriate vaseline together with the drug powder of (2) and be mixed into paste.
Described component two is prepared into aerosol, method is as follows: take Herba boeae clarkeanae, Rhizoma Alpiniae Officinarum, Herba Erodii, Radix Notoginseng, Rhizoma Dioscoreae Nipponicae, Radix Alangii, Caulis Piperis Kadsurae, Ramulus et Folium Bauhiniae Faberi, root of subprostrate sophora, Rhizoma Coptidis, Cortex Phellodendri, Nidus Vespae, Rhizoma Polygoni Cuspidati, Radix Glycyrrhizae etc. by recipe quantity and be ground into coarse powder, cross 60 mesh sieves, drop in extraction pot.Add the water of 5 times amount, circumfluence distillation 2 hours, carries 2 times altogether at every turn.Merge the extracting solution of 2 times, filter, be concentrated into 1:1.Adding 95% ethanol to ethanol content in concentrated solution is 80%, leaves standstill 24 hours, filters, and reclaims ethanol.Three times repeatedly.Filtrate merged concentrated, add appropriate Oleum menthae, tween 80, mixing clarification, filters, fill.
During use, conventional debridement, after removing slough, aerosol is evenly sprayed at whole wound surface, after drying, smear external application paste, unguentum is jet stream cloud agent more on the surface, and finally with antiseptic gauze wrapping, every day changes dressings once.
Decubital ulcer is one of clinical modal complication, and sickness rate is up to 1-4.7%, and disease is rapid, is difficult to cure, very easily recurs after healing.The early stage skin rubefaction of decubital ulcer, takes to stand up, can take a turn for the better after the measure such as decompression.Just hospital for treatment should be arrived in time when skin occurs that shallow table festers, ulcer, transudate are many.Cureless decubital ulcer can elderly patients' lethal disease such as concurrent osteomyelitis, septicemia and hypoproteinemia, becomes typical bed patient No.1 " killer ".
The traditional Chinese medical science thinks that decubital ulcer is interior hot and suffocating or experience summer-heat poison, and antiperspirant is let out smooth, and heat-damp in summer pyretic toxicity accumulates steaming, and to cause Shi Re Bing Pian stagnant in skin, and meridians block, stagnation of QI-blood, and the resistance of pathogenic heat QI and blood is tied between skin and flesh, and intenseness of heat meat is rotten, and meat corruption is pus, the clinical symptoms shown.The present inventor thinks the Therapeutic Principle of primary disease with benefiting vital QI and blood and battalion's poison holding for controlling, and actively improves sufferer systemic conditions.The unguentum Radix Astragali, the Chinese angelica blood supplementing QI invigorating of instant component one consolidate, and are all monarch drug; Radix Et Rhizoma Rhei, Flos Chrysanthemi Indici, Radix Sophorae Flavescentis, Bulbus Fritillariae Thunbergii, Radix Arnebiae (Radix Lithospermi), Indigo Naturalis, Fructus Gardeniae, Lasiosphaera Seu Calvatia heat-clearing and toxic substances removing are ministerial drug, Flos Carthami, succinum, Galla Chinensis blood circulation and promoting silt are adjuvant drug, the each component of medicine is collaborative to be had QI invigorating and consolidates in order to make for Os Draconis, Halloysitum Rubrum, Sanguis Draxonis, catechu, grass dragon, Margarita, Aloe, Borneolum Syntheticum removing the necrotic tissue and promoting granulation, and seeks effect of poison holding.External application can improve blood circulation, regulates metabolism, promotes tissue repair, antiinflammatory, immunity moderation function.Component two Rhizoma Polygoni Cuspidati used, Caulis Piperis Kadsurae, the broken silt of Radix Alangii dredging collateral; Cortex Phellodendri, Rhizoma Coptidis, root of subprostrate sophora, Ramulus et Folium Bauhiniae Faberi heat-clearing and toxic substances removing; Rhizoma Alpiniae Officinarum, Radix Notoginseng, Herba Erodii dispelling cold and absorbing clot; Rhizoma Dioscoreae Nipponicae, Nidus Vespae wind-expelling pain-stopping; After debridement, spray is with can wind-expelling pain-stopping, and further disinfecting detoxifying, strengthens the effect of local promoting blood circulation to remove obstruction in the collateral, be conducive to removing the necrotic tissue and promoting granulation.With Dressed plaster Synergistic, promoting blood circulation, benefiting qi for promoting granulation, improves wound surface microcirculation, accelerates disease damage tissue repair and enhancing human body immunity function, can promote angiogenesis, promotes granulation tissue growth, promotes wound tissue reparation.The each phase decubital ulcer of clinical treatment, cure rate is high, short treating period, instant effect, achieves significant curative effect.
The pharmacological action of each component used is as follows:
The Radix Astragali: sweet, temperature.Return lung, spleen channel.Invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.
Radix Angelicae Sinensis: sweet, acrid, warm.Return liver, the heart, spleen channel.Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.
Radix Et Rhizoma Rhei: bitter, cold.Return spleen, stomach, large intestine, liver, pericardium channel.Purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.For excess-heat constipation, stagnant stomachache, dysentery is not well, jaundice due to damp-heat, and heat in blood tells nosebleed, conjunctival congestion, pharyngeal swelling, abdominalgia with intestinal abscess, carbuncle furuncle, blood stasis amenorrhea, traumatic injury, external treatment burn due to hot liquid or fire; Upper gastrointestinal hemorrhage.
Flos Chrysanthemi Indici: be slightly cold; Pungent, bitter; Return lung, Liver Channel.Heat-clearing and toxic substances removing; Dispelling wind suppressing the hyperactive liver.Cure mainly: furuncle; Carbuncle; Erysipelas; Eczema; Dermatitis; Anemopyretic cold; Laryngopharynx swelling and pain; Hypertension.
Radix Sophorae Flavescentis: bitter in the mouth; Cold in nature.Return liver; Kidney; Large intestine; Small intestine meridian; Bladder; Heart channel; Urinary bladder channel.Heat clearing and damp drying; Wind dispelling insecticide.Main damp-heat dysentery; Discharging fresh blood stool; Jaundice; Dysuria; Edema; Leukorrhagia; Pudendal pruritus; Scabies; Leprosy; Skin pruritus; Noxious dampness skin infection.
Bulbus Fritillariae Thunbergii: removing heat-phlegm, powder detoxifcation.Control cough due to pathogenic wind-heat, lung abscess sore throat, scrofula, sore swollen toxin.
Radix Arnebiae (Radix Lithospermi): cold in nature is sweet in the mouth, salty.GUIXIN, Liver Channel.Removing heat from blood, invigorates blood circulation, removing toxic substances rash.Contain for heat in blood poison, macule purple is black, measles without adequate eruption, skin infection, eczema, burn due to hot liquid or fire.Clearing away heat and cooling blood, for measles, calentura skin eruption, eczema, hematuria, stranguria with blood, dysentery, skin infection, erysipelas, burn, constipation with heat retention.
Flos Carthami: warm in nature, acrid in the mouth, promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, traumatic injury.
Galla Chinensis: sour in the mouth is puckery, cold in nature.Return lung, large intestine, kidney channel.Astringe the lung; Hidroschesis; Astringing intestine to stop diarrhea; Controlling nocturnal emission with astringent drugs; Hemostasis; Removing toxic substances.Cure mainly: chronic cough of deficiency lung; Spontaneous sweating; Chronic dysentery chronic diarrhea; Proctoptosis; Seminal emission; Nebulousurine; Various hemorrhage; Carbuncle furuncle.
Succinum: sweet is flat.Calmness, diuresis, invigorates blood circulation.For infantile convulsion, epilepsy, cardiopalmus, insomnia, dysuria, dysurea, hematuria, amenorrhea.
Indigo Naturalis: salty, cold.Return Liver Channel.Heat-clearing and toxic substances removing, removing heat from blood, arresting convulsion.For maculae caused by violent heat pathogen, heat in blood tells nosebleed, chest pain hemoptysis, aphtha, mumps, sore throat, pediatric epilepsy scared.
Os Draconis: sweet, puckery are flat.Calmness, arresting sweating arresting seminal emission, promoting tissue regeneration and ulcer healing.For neurasthenia, cardiopalmus, insomnia, dreaminess, spontaneous perspiration, night sweat, seminal emission, the enuresis, metrorrhagia, leukorrhagia; External control skin infection for a long time burst do not hold back.Halloysitum Rubrum: sweet, sour, puckery, temperature.Return stomach, large intestine channel.Astringing intestine to stop diarrhea, hemostasis, promoting tissue regeneration and ulcer healing.For chronic diarrhea chronic dysentery, fecal blood, bleeding not during menses; External treatment skin infection is not held back, and eczema pus is contaminated.
Lasiosphaera Seu Calvatia: pungent; Property is put down.Lung meridian.Removing heat from the lung and relieving sorethroat, removing toxic substances hemostasis.Main laryngopharynx swelling and pain, cough with aphonia, hematemesis and epistaxis, all skin ulcers are not held back.
Sanguis Draxonis: sweet, salty is flat.GUIXIN, Liver Channel.Removing blood stasis and relieving pain, hemostasia and promoting granulation.Lose for falling to flutter, ecchymoma due to internal injury; Continuous bleeding due to traumatic injury.
Catechu: bitter, puckery, is slightly cold.Return lung meridian.Removing dampness promoting tissue regeneration and ulcer healing.For ulcer being unable to heal, eczema, aphtha, falls and flutters the pain of injury, traumatic hemorrhage.
Grass dragon: light, cool.Heat-clearing and toxic substances removing, removing the necrotic tissue and promoting granulation.For cold, fever, laryngopharynx swelling and pain, stomatitis, oral ulcer, carbuncle furuncle swells.
Fructus Gardeniae: bitter; Bitterly disappointed; Liver; Lung; Stomach; Tri-jiao channel.Pathogenic fire purging relieving restlessness; Clearing away heat-damp and promoting diuresis; Removing pathogenic heat from blood and toxic substance from the body.Main calentura is vexed; Liver-fire conjunctival congestion; Headache; Damp and hot yellow infantile malnutrition; Stranguria; Leaf blood epistaxis; Dysentery hematuria; Aphtha of the mouth and tongue; Sore swollen toxin; Sprain and swell and ache
Margarita: sweet, salty, cold.GUIXIN, Liver Channel.To calm the nerves arresting convulsion, improving eyesight removing nebula, removing toxic substances and promoting granulation.For insomnia of palpitating with fear, infantile convulsion epilepsy, the raw nebula of order, skin infection is not held back.
Borneolum Syntheticum: pungent, bitter, is slightly cold.GUIXIN, spleen, lung meridian.To have one's ideas straightened out refreshment, clearing away heat to alleviate pain.Faint for calentura coma, convulsion, apoplexy syncope due to accumulation of phlegm, stagnation of QI sudden syncope, attacked by pestiferous factors is gone into a coma, and conjunctival congestion, aphtha, laryngopharynx swelling and pain, auditory meatus is suppurated.
Aloe: bitter, cold.Return liver, stomach, large intestine channel.Removing heat from the liver, relieving constipation.For constipation, infantile malnutrition, infantile convulsion; External treatment exudative dermatitis.
Herba boeae clarkeanae: bitter, cold.Antiinflammatory, removing heat from blood, synthetism.For bronchitis, tonsillitis, lung-heat hemoptysis, skin ulcer, furuncle, mastitis, proctoptosis, hemorrhoid, tumor, traumatic hemorrhage, burn and scald, fracture.
Rhizoma Alpiniae Officinarum: pungent, heat.Return spleen, stomach warp.Warming stomach for dispelling cold, help digestion pain relieving.For coldness and pain in the epigastrium, gastrofrigid vomiting, belch acid regurgitation.
Herba Erodii: pungent, bitter, flat.Return liver,kidney,spleen warp.Wind-damp dispelling, the meridian dredging, antidiarrheal profit.For rheumatic arthralgia, numbness contracture, muscles and bones is ached, dysentery.
Radix Notoginseng: sweet, micro-hardship, temperature.Return liver, stomach warp.Dissipating blood stasis stops blooding, subduing swelling and relieving pain.For spitting of blood, spit blood, epistaxis, has blood in stool, metrorrhagia, traumatic hemorrhage, and breast abdomen twinges, tumbling and swelling.
Rhizoma Dioscoreae Nipponicae: bitter, flat.Relaxing muscles and tendons and activating QI and blood in the collateral, wind-expelling pain-stopping.For rheumatalgia, rheumatic arthritis, muscles and bones is numb, Kaschin-Beck disease, traumatic injury, bronchitis.
Radix Alangii: pungent, temperature, poisonous.Dispel the wind, dredging collateral, dissipating blood stasis, analgesia, and have anesthesia and relaxed muscle effect.Dispelling the wind and dampness pathogens pain, paralysis and numbness, heart failure, impairment caused by overstrain lumbago, traumatic injury.
Caulis Piperis Kadsurae: pungent, bitter, tepor.Return Liver Channel.Wind-damp dispelling, the meridian dredging, stopping numbness pain.For anemofrigid-damp arthralgia, arthrodynia of extremities, the contracture of muscle arteries and veins, joint stuffiness.
Ramulus et Folium Bauhiniae Faberi: micro-hardship, micro-acid is cool.Heat-clearing and toxic substances removing, dampness removing is antipruritic.For bacillary dysentery, amebic dysentery, enteritis, intestinal infusorian, dyspepsia, bronchitis, pyelonephritis; Eczema, dermatitis, skin pruritus are controlled in external.
Root of subprostrate sophora: cold in nature, bitter in the mouth.Qinghuo Jiedu, reducing swelling and alleviating pain.For throat gingival swelling and pain, cough due to lung-heat's excessive thirst, jaundice, constipation with heat retention.
Rhizoma Coptidis: bitter, cold.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood tells nosebleed, conjunctival congestion, and toothache, quenches one's thirst, carbuncle furuncle; External treatment eczema, eczema, auditory meatus is suppurated.It is burning hot that Rhizoma Coptidis (processed with wine) is apt to the clear part of the body cavity above the diaphragm housing the heart and lungs.For conjunctival congestion, aphtha.
Cortex Phellodendri: bitter, cold.Return kidney, urinary bladder channel.Heat clearing and damp drying, pathogenic fire purging removes steams, detoxification sore treatment.For damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity { is warded off }, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.
Nidus Vespae: dispel the wind, counteracting toxic substances, parasite killing.Control infantile convulsion, migratory arthralgia, urticaria pruritus, acute mastitis, furunculosis, scrofula, anal fistula, acute toothache, tinea capitis, honeybee stings swollen pain.
Rhizoma Polygoni Cuspidati: dispel the wind, dampness removing, removing blood stasis with potent drugs, stimulates the menstrual flow.Dispelling the wind and dampness pathogens bones and muscles pain, jaundice due to damp-heat, stranguria with turbid discharge leukorrhagia, women's amenorrhea, lochiostasis, lump in the abdomen, anal fistula hematochezia.Injury from falling down, scalds, malignant boil tinea disease.
Radix Glycyrrhizae: sweet, flat.GUIXIN, lung, spleen, stomach warp.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
The present invention has following beneficial effect:
The present invention follows the principle of tcm treatment according to syndrome differentiation, treating both the principal and secondary aspects of a disease, selected Chinese herbal medicine scientific compatibility, and a large amount of research practice basis is developed the Chinese prescription of special for treating decubital ulcer, and each component is collaborative to be done mutually, treating both the principal and secondary aspects of a disease.Clinical instant effect, cure time is short: without the need to operation, only adopts Chinese medicine composition of the present invention just can cure, greatly alleviates the misery of patient, and without any side effects.
Below in conjunction with clinical treatment situation, further illustrate curative effect of the present invention.
1 clinical data
1.1 physical data
Select in December, 2012 in April ,-2014 my institute to be in hospital and the patients with bedsore of outpatient service II-IV phase, totally 80 examples, man 49 example, female 31 example, age 31-84 year, 61.3 years old mean age.II phase patient 26 example, III phase patient 30 example, IV phase patient 24 example.Be divided into two groups at random.Treatment group 40 example, matched group 40 example.Two groups of physical data are through statistical procedures, and there was no significant difference, has comparability.
2 Therapeutic Method
Treatment group: while basic nursing, adopts medicine composite for curing of the present invention: after conventional debridement, aerosol is evenly sprayed at whole wound surface, and after drying, smearing ointment, ointment jet stream cloud agent on the surface, finally with antiseptic gauze wrapping, every day changes dressings once.
Matched group: while basic nursing, wrap up with sterile vaseline gauze and dressing with after 1:5000 furacilin solution cleaning wound surface, every day changes dressings once again.
Two groups are all carried out therapeutic evaluation in medication after 15 days.Give regularly to stand up according to " basic nursing science " routine care, part massage.III, IV phase patient give air fluidized bed.
3 criterions of therapeutical effect
Cure: wound surface heals completely.Effective: wound surface reduces more than 1/2.Effective: wound surface reduces 1/4-1/2.Invalid: wound surface reduces and is less than 1/4 or expansion.
Carry out data statistics with SPSS19.0 statistical software, use X 2inspection, P<0.05 is for there being significant difference, and P<0.01 is for there being pole significant difference.
4 therapeutic outcomes
Two groups of curative effects are in table 1
Table 1 liang group decubital ulcer comparitive study example (%)
Grouping n Cure Effective Effectively Invalid Total effective rate %
Treatment group 40 17 12 10 1 97.5
Matched group 40 12 14 3 10 75
Two groups of curative effects can be found out, use traditional Chinese medicine composition for treating of the present invention, total effective rate reaches 97.5%, and P<0.05 has significant difference compared with matched group 75%.
Below enumerate model case and further illustrate effect of the present invention
Case one, Wang, man, 45 years old
Main suit: paraplegia 10 years after wound, RG festers and suppurates more than February.
History of present illness: patient before be set forth in 10 years because of wound cause spinal injury after cause paraplegia, long-term bed, on the right side of in late March, 2013, festering appears in buttocks, be in voluntarily medication process, without obvious curative effects, the state of an illness constantly increases the weight of, face of festering constantly expands, and tunnel.Modern medical for asking further diagnosis and treatment then to arrive my Out-patient Department, " decubital ulcer " is intended in outpatient service, " paraplegia " is hospitalized and is admitted to hospital.
Training checks: the visible 5cm × 5cm sinus tract mouth of left side buttocks, deeply about 6cm, and sinus tract surrounding tissue is turned black, and have a large amount of yellow water sample exudate to ooze out in sinus tract, matter is rare, and stench is obvious; Affected part surrounding skin poor flexibility, Pi Wenlvegao.
AD: 1, left side sciatic bedsore companion tunnel; 2, paraplegia.
Diagnosis and treatment scheme:
1, surgical nursing routine is given after being admitted to hospital, secondary care.
2, to sleep bedsore cushion, timing turning over
3, right side buttocks gives traditional Chinese medicine composition for treating of the present invention, changes dressings every day 1 time.To select a time debridement treatment.
Treat and drain faint yellow pus in rear right Hip Sinus in 10 days, measure comparatively and obviously reduce no foul smell, granulation growth better.Treat after 15 days, patient's left buttocks drain pus is clean gradually, and better, sinus tract obviously reduces in granulation growth.Treat patient's state of an illness after 1 month and recover good, left sciatic bedsore healing.
Detailed description of the invention
Embodiment 1. 1 kinds treats the Chinese medicine composition of decubital ulcer, comprises the crude drug of following component by weight:
Component one: the Radix Astragali 10 grams, Radix Angelicae Sinensis 10 grams, Radix Et Rhizoma Rhei 20 grams, Flos Chrysanthemi Indici 10 grams, Radix Sophorae Flavescentis 10 grams, Bulbus Fritillariae Thunbergii 5 grams, Radix Arnebiae (Radix Lithospermi) 10 grams, 10 grams, Flos Carthami, Galla Chinensis 5 grams, succinum 1 gram, Indigo Naturalis 3 grams, Os Draconis 5 grams, Halloysitum Rubrum 9 grams, Lasiosphaera Seu Calvatia 10 grams, Sanguis Draxonis 10 grams, 10 grams, catechu, grass dragon 10 grams, Fructus Gardeniae 5 grams, Margarita 1 gram, Borneolum Syntheticum 1 gram, Aloe 1 gram;
Component two: Herba boeae clarkeanae 10 grams, Rhizoma Alpiniae Officinarum 3 grams, Herba Erodii 9 grams, Radix Notoginseng 9 grams, Rhizoma Dioscoreae Nipponicae 3 grams, Radix Alangii 5 grams, Caulis Piperis Kadsurae 6 grams, Ramulus et Folium Bauhiniae Faberi 10 grams, root of subprostrate sophora 5 grams, Rhizoma Coptidis 10 grams, Cortex Phellodendri 10 grams, Nidus Vespae 10 grams, Rhizoma Polygoni Cuspidati 10 grams, 10 grams, Radix Glycyrrhizae.
Described component one is prepared into external application paste, and method is as follows:
(1) take the Radix Astragali by recipe quantity, Radix Angelicae Sinensis, Radix Et Rhizoma Rhei, Radix Sophorae Flavescentis, Radix Arnebiae (Radix Lithospermi), Flos Chrysanthemi Indici, Fructus Gardeniae be ground into coarse powder, cross 60 mesh sieves, drop in extraction pot.Add the water of 7 times amount, circumfluence distillation 2 hours, carries 3 times altogether at every turn.Merge the extracting solution of 3 times, filter, be concentrated into 1:1.Add 95% ethanol in concentrated solution, leave standstill 24 hours, centrifugal, be precipitated as crude extract.Extract is dry with vacuum drying oven, namely obtains drug extract powder for subsequent use after micronizing;
(2) take the superfine powder such as Bulbus Fritillariae Thunbergii, Galla Chinensis, succinum, Indigo Naturalis, Os Draconis, Halloysitum Rubrum, Lasiosphaera Seu Calvatia, Sanguis Draxonis, catechu, grass dragon, Margarita, Borneolum Syntheticum, Aloe by recipe quantity and be broken into fine powder, powder footpath is 5-10 μm;
(3) the drug extract powder of above-mentioned (1) is added appropriate vaseline together with the drug powder of (2) and be mixed into paste.
Described component two is prepared into aerosol, method is as follows: take Herba boeae clarkeanae, Rhizoma Alpiniae Officinarum, Herba Erodii, Radix Notoginseng, Rhizoma Dioscoreae Nipponicae, Radix Alangii, Caulis Piperis Kadsurae, Ramulus et Folium Bauhiniae Faberi, root of subprostrate sophora, Rhizoma Coptidis, Cortex Phellodendri, Nidus Vespae, Rhizoma Polygoni Cuspidati, Radix Glycyrrhizae etc. by recipe quantity and be ground into coarse powder, cross 60 mesh sieves, drop in extraction pot.Add the water of 5 times amount, circumfluence distillation 2 hours, carries 2 times altogether at every turn.Merge the extracting solution of 2 times, filter, be concentrated into 1:1.Adding 95% ethanol to ethanol content in concentrated solution is 80%, leaves standstill 24 hours, filters, and reclaims ethanol.Three times repeatedly.Filtrate merged concentrated, add appropriate Oleum menthae, tween 80, mixing clarification, filters, fill.
During use, conventional debridement, is evenly sprayed at whole wound surface by aerosol after removing slough, and after drying, smearing ointment, ointment covers skin ulcer face, thickness 0.5 cm.Ointment jet stream cloud agent on the surface, finally with antiseptic gauze wrapping, every day changes dressings once.
Embodiment 2. 1 kinds treats the Chinese medicine composition of decubital ulcer, and gram meter comprises the crude drug of following component by weight:
Component one: the Radix Astragali 30 grams, Radix Angelicae Sinensis 30 grams, Radix Et Rhizoma Rhei 30 grams, Flos Chrysanthemi Indici 20 grams, Radix Sophorae Flavescentis 20 grams, Bulbus Fritillariae Thunbergii 10 grams, Radix Arnebiae (Radix Lithospermi) 20 grams, 20 grams, Flos Carthami, Galla Chinensis 10 grams, succinum 3 grams, Indigo Naturalis 5 grams, Os Draconis 10 grams, Halloysitum Rubrum 12 grams, Lasiosphaera Seu Calvatia 15 grams, Sanguis Draxonis 15 grams, 15 grams, catechu, grass dragon 15 grams, Fructus Gardeniae 10 grams, Margarita 3 grams, Borneolum Syntheticum 3 grams, Aloe 3 grams;
Component two: Herba boeae clarkeanae 15 grams, Rhizoma Alpiniae Officinarum 6 grams, Herba Erodii 15 grams, Radix Notoginseng 15 grams, Rhizoma Dioscoreae Nipponicae 9 grams, Radix Alangii 10 grams, Caulis Piperis Kadsurae 12 grams, Ramulus et Folium Bauhiniae Faberi 20 grams, root of subprostrate sophora 10 grams, Rhizoma Coptidis 30 grams, Cortex Phellodendri 30 grams, Nidus Vespae 15 grams, Rhizoma Polygoni Cuspidati 15 grams, 20 grams, Radix Glycyrrhizae.
Method of preparation and use is with embodiment 1.
Embodiment 3. 1 kinds treats the Chinese medicine composition of decubital ulcer, and gram meter comprises the crude drug of following component by weight:
Component one: the Radix Astragali 20 grams, Radix Angelicae Sinensis 20 grams, Radix Et Rhizoma Rhei 25 grams, Flos Chrysanthemi Indici 15 grams, Radix Sophorae Flavescentis 15 grams, Bulbus Fritillariae Thunbergii 6 grams, Radix Arnebiae (Radix Lithospermi) 15 grams, 15 grams, Flos Carthami, Galla Chinensis 8 grams, succinum 2 grams, Indigo Naturalis 4 grams, Os Draconis 8 grams, Halloysitum Rubrum 10 grams, Lasiosphaera Seu Calvatia 12 grams, Sanguis Draxonis 12 grams, 12 grams, catechu, grass dragon 12 grams, Fructus Gardeniae 8 grams, Margarita 2 grams, Borneolum Syntheticum 2 grams, Aloe 2 grams;
Component two: Herba boeae clarkeanae 12 grams, Rhizoma Alpiniae Officinarum 5 grams, Herba Erodii 12 grams, Radix Notoginseng 12 grams, Rhizoma Dioscoreae Nipponicae 6 grams, Radix Alangii 8 grams, Caulis Piperis Kadsurae 10 grams, Ramulus et Folium Bauhiniae Faberi 15 grams, root of subprostrate sophora 8 grams, Rhizoma Coptidis 20 grams, Cortex Phellodendri 20 grams, Nidus Vespae 12 grams, Rhizoma Polygoni Cuspidati 12 grams, 15 grams, Radix Glycyrrhizae.
Method of preparation and use is with embodiment 1.
Embodiment 4. 1 kinds treats the Chinese medicine composition of decubital ulcer, and gram meter comprises the crude drug of following component by weight:
Component one: the Radix Astragali 25 grams, Radix Angelicae Sinensis 25 grams, Radix Et Rhizoma Rhei 25 grams, Flos Chrysanthemi Indici 15 grams, Radix Sophorae Flavescentis 17 grams, Bulbus Fritillariae Thunbergii 8 grams, Radix Arnebiae (Radix Lithospermi) 18 grams, 18 grams, Flos Carthami, Galla Chinensis 6 grams, succinum 3 grams, Indigo Naturalis 5 grams, Os Draconis 7 grams, Halloysitum Rubrum 11 grams, Lasiosphaera Seu Calvatia 13 grams, Sanguis Draxonis 14 grams, 11 grams, catechu, grass dragon 14 grams, Fructus Gardeniae 7 grams, Margarita 1 gram, Borneolum Syntheticum 2 grams, Aloe 3 grams;
Component two: Herba boeae clarkeanae 13 grams, Rhizoma Alpiniae Officinarum 4 grams, Herba Erodii 10 grams, Radix Notoginseng 10 grams, Rhizoma Dioscoreae Nipponicae 8 grams, Radix Alangii 6 grams, Caulis Piperis Kadsurae 6 grams, Ramulus et Folium Bauhiniae Faberi 18 grams, root of subprostrate sophora 9 grams, Rhizoma Coptidis 25 grams, Cortex Phellodendri 25 grams, Nidus Vespae 14 grams, Rhizoma Polygoni Cuspidati 14 grams, 17 grams, Radix Glycyrrhizae.
Method of preparation and use is with embodiment 1.

Claims (3)

1. treat a Chinese medicine composition for decubital ulcer, it is characterized in that, comprise the crude drug of following component by weight:
Component one: Radix Astragali 10-30 part, Radix Angelicae Sinensis 10-30 part, Radix Et Rhizoma Rhei 20-30 part, Flos Chrysanthemi Indici 10-20 part, Radix Sophorae Flavescentis 10-20 part, Bulbus Fritillariae Thunbergii 5-10 part, Radix Arnebiae (Radix Lithospermi) 10-20 part, Flos Carthami 10-20 part, Galla Chinensis 5-10 part, succinum 1-3 part, Indigo Naturalis 3-5 part, Os Draconis 5-10 part, Halloysitum Rubrum 9-12 part, Lasiosphaera Seu Calvatia 10-15 part, Sanguis Draxonis 10-15 part, catechu 10-15 part, careless imperial 10-15 part, Fructus Gardeniae 5-10 part, Margarita 1-3 part, Borneolum Syntheticum 1-3 part, Aloe 1-3 part;
Component two: Herba boeae clarkeanae 10-15 part, Rhizoma Alpiniae Officinarum 3-6 part, Herba Erodii 9-15 part, Radix Notoginseng 9-15 part, Rhizoma Dioscoreae Nipponicae 3-9 part, Radix Alangii 5-10 part, Caulis Piperis Kadsurae 6-12 part, Ramulus et Folium Bauhiniae Faberi 10-20 part, root of subprostrate sophora 5-10 part, Rhizoma Coptidis 10-30 part, Cortex Phellodendri 10-30 part, Nidus Vespae 10-15 part, Rhizoma Polygoni Cuspidati 10-15 part, Radix Glycyrrhizae 10-20 part.
2. the Chinese medicine composition for the treatment of decubital ulcer as claimed in claim 1, is characterized in that, comprise the crude drug of following component by weight:
Component one: the Radix Astragali 20 parts, Radix Angelicae Sinensis 20 parts, Radix Et Rhizoma Rhei 25 parts, Flos Chrysanthemi Indici 15 parts, Radix Sophorae Flavescentis 15 parts, Bulbus Fritillariae Thunbergii 6 parts, Radix Arnebiae (Radix Lithospermi) 15 parts, 15 parts, Flos Carthami, Galla Chinensis 8 parts, succinum 2 parts, Indigo Naturalis 4 parts, Os Draconis 8 parts, Halloysitum Rubrum 10 parts, Lasiosphaera Seu Calvatia 12 parts, Sanguis Draxonis 12 parts, 12 parts, catechu, grass dragon 12 parts, Fructus Gardeniae 8 parts, Margarita 2 parts, Borneolum Syntheticum 2 parts, Aloe 2 parts;
Component two: Herba boeae clarkeanae 12 parts, Rhizoma Alpiniae Officinarum 5 parts, Herba Erodii 12 parts, Radix Notoginseng 12 parts, Rhizoma Dioscoreae Nipponicae 6 parts, Radix Alangii 8 parts, Caulis Piperis Kadsurae 10 parts, Ramulus et Folium Bauhiniae Faberi 15 parts, root of subprostrate sophora 8 parts, Rhizoma Coptidis 20 parts, Cortex Phellodendri 20 parts, Nidus Vespae 12 parts, Rhizoma Polygoni Cuspidati 12 parts, 15 parts, Radix Glycyrrhizae.
3. the method for the Chinese medicine composition of the treatment decubital ulcer of preparation described in claim 1 or 2, it is characterized in that, method is as follows:
Described component one is prepared into external application paste, and step is:
(1) take the Radix Astragali by recipe quantity, Radix Angelicae Sinensis, Radix Et Rhizoma Rhei, Radix Sophorae Flavescentis, Radix Arnebiae (Radix Lithospermi), Flos Chrysanthemi Indici, Fructus Gardeniae be ground into coarse powder, cross 60 mesh sieves, drop in extraction pot; Add the water of 7 times amount, circumfluence distillation 2 hours, carries 3 times altogether at every turn; Merge the extracting solution of 3 times, filter, be concentrated into 1:1; Add 95% ethanol in concentrated solution, leave standstill 24 hours, centrifugal, be precipitated as crude extract; Extract is dry with vacuum drying oven, namely obtains drug extract powder for subsequent use after micronizing;
(2) take Bulbus Fritillariae Thunbergii by recipe quantity, Galla Chinensis, succinum, Indigo Naturalis, Os Draconis, Halloysitum Rubrum, Lasiosphaera Seu Calvatia, Sanguis Draxonis, catechu, grass dragon, Margarita, Borneolum Syntheticum, Aloe superfine powder be broken into fine powder, powder footpath is 5-10 μm;
(3) the drug extract powder of above-mentioned (1) is added appropriate vaseline together with the drug powder of (2) and be mixed into paste;
Described component two is prepared into aerosol, step is: take Herba boeae clarkeanae by recipe quantity, Rhizoma Alpiniae Officinarum, Herba Erodii, Radix Notoginseng, Rhizoma Dioscoreae Nipponicae, Radix Alangii, Caulis Piperis Kadsurae, Ramulus et Folium Bauhiniae Faberi, root of subprostrate sophora, Rhizoma Coptidis, Cortex Phellodendri, Nidus Vespae, Rhizoma Polygoni Cuspidati, Radix Glycyrrhizae powder be broken into coarse powder, cross 60 mesh sieves, drop in extraction pot.Add the water of 5 times amount, circumfluence distillation 2 hours, carries 2 times altogether at every turn; Merge the extracting solution of 2 times, filter, be concentrated into 1:1; Adding 95% ethanol to ethanol content in concentrated solution is 80%, leaves standstill 24 hours, filters, and reclaims ethanol; Three times repeatedly, filtrate merged concentrated, add appropriate Oleum menthae, tween 80, mixing clarification, filters, fill.
CN201510963128.2A 2015-12-18 2015-12-18 Traditional Chinese medicine composition for treating bedsores and preparing method thereof Pending CN105381366A (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109481725A (en) * 2018-12-12 2019-03-19 徐子寒 A kind of instant Glycyrrhiza Oil Compound dressing and preparation method thereof

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CN104288504A (en) * 2014-09-11 2015-01-21 湘乡市尚如湖铁医院 Traditional Chinese medicinal ointment preparation for treating burn and scalds and preparation method thereof
CN104337913A (en) * 2014-10-31 2015-02-11 刘晓云 External Chinese medicinal composition for treating pressure sore

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CN101143171A (en) * 2007-08-29 2008-03-19 钱亚蒙 Traditional Chinese medicine and its preparation method and its application
CN103830478A (en) * 2014-02-13 2014-06-04 马翠霞 Medicine for treatment of skin ulcer
CN104288504A (en) * 2014-09-11 2015-01-21 湘乡市尚如湖铁医院 Traditional Chinese medicinal ointment preparation for treating burn and scalds and preparation method thereof
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* Cited by examiner, † Cited by third party
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Application publication date: 20160309